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Confessions Wraps Filming: Eastern Dark Aesthetics Meet the Abyss of Human Nature, Elevating Chinese Drama to New Heights


SHANGHAI, CHINA – Media OutReach Newswire – 8 May 2025 – Confessions, a psychological suspense series written and directed by Wong Ching-Po and starring Ethan Juan, Gingle Wang, Alyssa Chia, Yi-Wen Chen, and Vivian Sung, officially wrapped filming on May 3. Hosted by Bowie Tsang, the press conference gathered the full cast and creative team. The set, featuring tree root installations and a Mondrian-inspired carpet, was meticulously designed. With a stellar team including multiple Golden Horse and Golden Bell Award winners, Confessions has drawn strong interest from international markets.

Creative Roundtable: Elite Team Continues the Legacy, Delving Into the Gray Areas of Human Nature
Creative Roundtable: Elite Team Continues the Legacy, Delving Into the Gray Areas of Human Nature

The series, from the creative team behind The Pig, The Snake, and The Pigeon, underwent four months of preparation and 120 days of filming. Building on the “violent aesthetics and philosophical musings” of its predecessor, Confessions adds socially conscious suspense elements that heighten the narrative’s intensity and complexity. It delves deeper into psychological issues such as family trauma and moral conflict.

Ethan Juan shared that his character, Lin San, has a complex inner journey that mirrors many aspects of his own life. He described the experience as if he were stepping into Lin San’s shoes, not only portraying the character’s life but also undergoing a personal choice of his own throughout the process.

First Teaser: Stark Aesthetics Hit Home

At the press conference, the teaser trailer “Destined Suspense” was unveiled. With chilling lighting and intense sound design, it builds a bold aesthetic that amplifies suspense. The trailer reveals the characters’ psychological unraveling as they navigate family feuds and moral entanglements across two generations, drawing viewers into hidden truths and the abyss of human nature.

Eight character stills and a themed poster were unveiled, using black-and-white tones to evoke a sense of psychological warfare and mystery, deepening the audience’s immersion in the characters’ minds. The series will be introduced to mainland China by Youhug Media and Youku, and exclusively streamed on Youku.

Following the event, Confessions entered post-production. The team will fuse Eastern and Western cultural elements, using sharp editing and visual effects to help Chinese drama cross linguistic and regional borders. With its striking dark aesthetic and universal moral themes, the show aims to leave a bold mark on the psychological suspense genre and redefine the peak of Chinese storytelling.

The issuer is solely responsible for the content of this announcement.

Toys”R”Us Asia Launches “Live Toyful”: A New Era of Play for All Ages

HONG KONG, May 8, 2025 /PRNewswire/ — With 40 years as a leading name in toys and play, Toys”R”Us Asia proudly unveils its bold new brand promise, Live Toyful, marking the exciting culmination of a two-year transformation. Launching regionally this month, this campaign expands the brand’s appeal beyond families and children to embrace “kidults”, celebrating play as a vital part of everyday life for all ages.

Toys“R”Us Asia unveils its bold new brand promise, Live Toyful, aiming to redefine play as a lifestyle.
Toys“R”Us Asia unveils its bold new brand promise, Live Toyful, aiming to redefine play as a lifestyle.

Our new brand promise, Live Toyful, strategically positions Toys”R”Us Asia as more than a toy retailer—we’re redefining play as a lifestyle,” said Leo Tsoi, CEO of Toys”R”Us Asia. “This evolution reflects our commitment to becoming an integral part of our customers’ daily lives, creating meaningful experiences that inspire joy and resonate across generations.”

Grounded in extensive consumer insights from the 2024 consumer study, the Live Toyful philosophy responds to a cultural shift where modern consumers seek playful moments amidst their busy routines. Gen Z in particular views play as essential for stress relief, self-expression, and forming social connections, embracing toys, collectibles, wearables, and nostalgic items. Toys”R”Us Asia aims to integrate itself into daily life not just as a retailer but as the premier destination for toys, play, and lifestyle products that enhance everyday experiences.

To meet the needs of this evolving customer base, Toys”R”Us Asia has undergone a two-year transformation, introducing seven generations of concept stores designed with immersive layouts, curated experience zones, and cross-generational appeal. In May 2025, the Live Toyful spirit will debut in Shenzhen and Taiwan, with stores transformed into magical wonderlands for IP fans and kidults, creating a whimsical wonderland filled with thrilling surprises for fans of all ages. This marks the beginning of Live Toyful’s expansion, as its joyful spirit is set to spread across the region in the coming months.

Beyond the immersive store experience, Toys”R”Us Asia is bringing the spirit of Live Toyful into every aspect of life. Through its exclusive private label, playpop, the brand now extends beyond traditional toys into lifestyle products—thoughtfully designed to spark joy in everyday moments. From playthings to daily essentials, every touchpoint is crafted to inspire a truly holistic Toyful lifestyle.

Adding to the excitement, Toys”R”Us Asia teamed up with globally loved brands to engage fans across the region. In partnership with Minecraft and Mattel, the retailer offered a special range of products tied to the Minecraft movie. To further enhance the experience, customers who purchased Mattel’s Minecraft items, including Minecraft Movie Feature Roleplay and Minecraft 3.25″ Core Figures would receive a complimentary DLC code featuring a unique Minecraft character—bridging physical and digital play in a fresh and engaging way.

Toys”R”Us Asia has also teamed up with Zuru to introduce an exciting range of Mini Brands, showcasing miniature collectibles from various popular IPs. This new offering inspires limitless play and creativity for fans everywhere, inviting them to immerse themselves in imaginative adventures.

With Live Toyful, Toys”R”Us Asia signals its readiness to navigate the next phase of retailtainment. As the brand moves forward with new concepts, partnerships and product lines, it continues to build on its legacy while opening new opportunities for growth in an increasingly dynamic and diverse market environment.

About Toys”R”Us Asia (Holding) Limited

Toys”R”Us Asia’s vision is to fuel imagination and inspire our next generation through the power of toys and play. The company’s mission is to be the trusted toy leader, providing premier toys and inspiring play experiences for both kids and kidults.

Toys”R”Us Asia is headquartered in Hong Kong and currently operating approximately 470 stores across Asia, including mainland China, Japan, Malaysia, Hong Kong, Singapore, Taiwan, Thailand and Brunei – and licenses more than 90 stores in the Philippines and Macau (China). The company also operates across leading Asian eCommerce platforms as well as its own online stores in each market.

Toys”R”Us Asia (Holding) Limited is an independent legal entity that operates separately from all other Toys”R”Us current or former operating companies around the world.

Toys”R”Us Asia Launches “Live Toyful” A New Era of Play for All Ages

HONG KONG, May 8, 2025 /PRNewswire/ — With 40 years as a leading name in toys and play, Toys”R”Us Asia proudly unveils its bold new brand promise, Live Toyful, marking the exciting culmination of a two-year transformation. Launching regionally this month, this campaign expands the brand’s appeal beyond families and children to embrace “kidults”, celebrating play as a vital part of everyday life for all ages.

Toys“R”Us Asia unveils its bold new brand promise, Live Toyful, aiming to redefine play as a lifestyle.
Toys“R”Us Asia unveils its bold new brand promise, Live Toyful, aiming to redefine play as a lifestyle.

Our new brand promise, Live Toyful, strategically positions Toys”R”Us Asia as more than a toy retailer—we’re redefining play as a lifestyle,” said Leo Tsoi, CEO of Toys”R”Us Asia. “This evolution reflects our commitment to becoming an integral part of our customers’ daily lives, creating meaningful experiences that inspire joy and resonate across generations.”

Grounded in extensive consumer insights from the 2024 consumer study, the Live Toyful philosophy responds to a cultural shift where modern consumers seek playful moments amidst their busy routines. Gen Z in particular views play as essential for stress relief, self-expression, and forming social connections, embracing toys, collectibles, wearables, and nostalgic items. Toys”R”Us Asia aims to integrate itself into daily life not just as a retailer but as the premier destination for toys, play, and lifestyle products that enhance everyday experiences.

To meet the needs of this evolving customer base, Toys”R”Us Asia has undergone a two-year transformation, introducing seven generations of concept stores designed with immersive layouts, curated experience zones, and cross-generational appeal. In May 2025, the Live Toyful spirit will debut in Shenzhen and Taiwan, with stores transformed into magical wonderlands for IP fans and kidults, creating a whimsical wonderland filled with thrilling surprises for fans of all ages. This marks the beginning of Live Toyful’s expansion, as its joyful spirit is set to spread across the region in the coming months.

Beyond the immersive store experience, Toys”R”Us Asia is bringing the spirit of Live Toyful into every aspect of life. Through its exclusive private label, playpop, the brand now extends beyond traditional toys into lifestyle products—thoughtfully designed to spark joy in everyday moments. From playthings to daily essentials, every touchpoint is crafted to inspire a truly holistic Toyful lifestyle.

Adding to the excitement, Toys”R”Us Asia teamed up with globally loved brands to engage fans across the region. In partnership with Minecraft and Mattel, the retailer offered a special range of products tied to the Minecraft movie. To further enhance the experience, customers who purchased Mattel’s Minecraft items, including Minecraft Movie Feature Roleplay and Minecraft 3.25″ Core Figures would receive a complimentary DLC code featuring a unique Minecraft character—bridging physical and digital play in a fresh and engaging way.

Toys”R”Us Asia has also teamed up with Zuru to introduce an exciting range of Mini Brands, showcasing miniature collectibles from various popular IPs. This new offering inspires limitless play and creativity for fans everywhere, inviting them to immerse themselves in imaginative adventures.

With Live Toyful, Toys”R”Us Asia signals its readiness to navigate the next phase of retailtainment. As the brand moves forward with new concepts, partnerships and product lines, it continues to build on its legacy while opening new opportunities for growth in an increasingly dynamic and diverse market environment.

About Toys”R”Us Asia (Holding) Limited

Toys”R”Us Asia’s vision is to fuel imagination and inspire our next generation through the power of toys and play. The company’s mission is to be the trusted toy leader, providing premier toys and inspiring play experiences for both kids and kidults.

Toys”R”Us Asia is headquartered in Hong Kong and currently operating approximately 470 stores across Asia, including mainland China, Japan, Malaysia, Hong Kong, Singapore, Taiwan, Thailand and Brunei – and licenses more than 90 stores in the Philippines and Macau (China). The company also operates across leading Asian eCommerce platforms as well as its own online stores in each market.

Toys”R”Us Asia (Holding) Limited is an independent legal entity that operates separately from all other Toys”R”Us current or former operating companies around the world.

bolttech and Sumitomo Corporation announce strategic partnership

The partnership will form a joint venture to deliver technology-enabled embedded solutions  to distribution partners in Asia

SINGAPORE, May 8, 2025 /PRNewswire/ — bolttech, the fast-growing global insurtech, today announced its partnership with Sumitomo Corporation, one of Japan’s largest trading houses. The two companies will enter a joint venture to deliver technology-enabled embedded solutions to distribution partners across a number of markets in Asia.

The technology-enabled embedded solutions will enable distribution partners to provide end-to-end device lifecycle management services, such as device upgrade, enhancing their ability to offer seamless and comprehensive solutions to customers in the region.

With smartphone prices rising and penetration increasing in emerging markets, the global demand for device protection services is on the rise. This trend is particularly pronounced in South Asia and Southeast Asia, where the demand for affordable, high-performance used smartphones is growing, driven by the growing proportion of young consumers. With the market for device protection expected to grow faster than the global average, there is a growing need for technology-driven device insurance and protection solutions.

The partnership will kick off with a launch in Southeast Asia focusing on a device upgrade programme, leveraging bolttech’s distribution capabilities and Sumitomo Corporation’s vast network of financing and guarantees capabilities.

Shinichi Kato, Group CEO of Media & Digital Group at Sumitomo Corporation, said, “We are thrilled to join forces with bolttech, a partner with proven track record in offering technology-enabled solutions to address consumer needs. We are confident that this partnership will enable us to leverage our combined expertise and resources to deliver industry-leading device lifecycle management services, driving growth and innovation across the Asia region.”

Rob Schimek, Group Chief Executive Officer, bolttech, said, “We are delighted to welcome Sumitomo Corporation as our strategic partner. We are confident that Sumitomo Corporation’s expertise in devices and vast network, combined with our distribution capabilities, will drive us forward in creating a better protection experience for consumers in Asia. We are excited to continue our journey in shaping the future of insurance, working towards our vision of connecting people with more ways to protect the things they value.”

– End –

Accompanying photo:

Name and titles of individuals in photo

Front Line (from left to right): 

1.  Kshitij Chitransh – Director, New Business Development, SC-Nex
2.  Shun Ohishi – Deputy Director, Device Solution Team No.1
3.  Liam Riley – General Manager – bolttomo
4.  Takehiko Kotani – Director, Device Solution Team No.1

Second Line (from left to right): 

5.  Yuya Hasebe – Senior Associate, Device Solution Team No.1
6.  Kazushi Awa – Executive Officer, Group CFO, Media & Digital Group
7.  Eisuke Takenaka – Executive Officer, General Manager, Smart Communication Platform SBU
8.  Shinichi Kato – Senior Managing Executive Officer, Group CEO, Media & Digital Group
9.  Rob Schimek – Group CEO
10. Fi Fi Lu – Group Head of Embedded Device and Head of Product, Asia
11. Akiko Anzai – General Manager, Japan

Third Line (from left to right): 

12. Alister Musgrave – Regional General Manager – Hong Kong, Taiwan & Japan 
13. Yusuke Nakajo – Senior Associate, Device Solution Team No.1 
14. Hirano Yuki – Senior Executive, Smart Communication Platform SBU 
15. Tomoyuki Shionoya – Head, Smart Service Business Unit 
16. Stephan Tan –  Group Chief Investment Officer, and CEO, Europe & Africa 
17. Makiko Eda – Managing Executive Officer, Chief Sustainability & DE&I Officer, Deputy Group CEO, Media & Digital Group 
18. Andy Ho –  Group Head of Mergers and Acquisitions 
19. Eric Lai – Group Deputy General Counsel  

Dorsett Wanchai and Dorsett Mongkok Promise a Fantastic Summer Vacation for Families

Enjoy up to 35% off for family rooms with complimentary breakfast and delightful amenities for the little ones


HONG KONG SAR – Media OutReach Newswire – 8 May 2025 – As summer approaches, the award-winning Dorsett Wanchai, Hong Kong, and Dorsett Mongkok, Hong Kong under Dorsett Hospitality International, are thrilled to introduce the Family Stay & Play experience for family travelers. With the Fantastic 4 Family package, guests can enjoy up to 35% off family rooms, complimentary breakfast for the entire family, and a wide range of thoughtful and delightful amenities for the little ones.

Dorsett Wanchai and Dorsett Mongkok Promise a Fantastic Summer Vacation for Families

A Beyond Thoughtful Family Stay & Play Experience

From the moment guests step into the hotel, they are welcomed by a complimentary candy bar (available daily from 6-7 pm). Upon check-in, children receive a surprise “Little Foodies” snack box and the hotel’s signature Jasper teddy, providing adorable companionship throughout their stay in Hong Kong.

Inside the rooms, families will find a range of kids’ amenities, including kid-size slippers and branded shower products. For families traveling with babies, the hotels offer complimentary rentals of baby cots, feeding amenities, and bathing and hygiene essentials, ensuring a hassle-free stay. To keep kids entertained, Teddy Jasper’s Adventure Kit, complete with board games and a music night light, is also available.

At Dorsett Wanchai, children will be delighted with an in-room piñata surprise (for selected bookings) and the Star Wars pinball machine in the hotel lobby.

Enjoy up to 35% off stays in our spacious family rooms, including Triple Rooms, Family Quad Rooms, and Interconnecting Rooms with our Fantastic 4 Family package. Additional benefits include:

  • Complimentary daily breakfast for the whole family
  • Flexible check-in/out times and a full 26-hour stay (exclusive to official website bookings)^
  • Branded bath amenities and personalized slippers for kids
  • Welcome gifts such as the “Little Foodies” Snack Box, Jasper Teddy and in-room surprise sweet treats
  • Free Baby Gear Rentals, including baby dining essentials, bathing and hygiene amenities, and Jasper’s Adventure Kit for a fun stay experience

BOOK NOW to take advantage of these fantastic offers and enjoy a truly memorable stay! For more information and reservation, please visit:

^Not applicable to Family Quad Room bookings at Dorsett Mongkok. Above offers are available from now until December 31, 2025. Please refer to the hotel website for details.

Hashtag: #DorsettWanchai #DorsettMongkok

The issuer is solely responsible for the content of this announcement.

Palauan Voyaging Canoe Alingano Maisu Nears Taiwan: A Cross-Pacific Cultural Exchange Anchored in Indigenous Maritime Traditions

TAITUNG, May 8, 2025 /PRNewswire/ — This summer, the Taitung County Government proudly welcomes an 11-member crew of traditional navigators from Palau, led by renowned master navigator Sesario Sewralur, departed on April 20 aboard the Alingano Maisu—a traditional Polynesian voyaging canoe—navigating without modern instruments. Guided by stars, ocean swells, and currents, the crew is expected to arrive in Lanyu on May 8 and Taitung’s Cidong community on May 10, marking a significant milestone in a cross-Pacific cultural exchange between Taiwan and Palau.

A Palauan vessel carrying an 11-member crew of sailors is set to arrive in Taiwan soon, following a long-distance voyage across the Pacific Ocean.
A Palauan vessel carrying an 11-member crew of sailors is set to arrive in Taiwan soon, following a long-distance voyage across the Pacific Ocean.

This initiative centers on the theme of “Voyaging and Canoe-Building Culture,” celebrating the deep-rooted Austronesian connection between the two regions. As island nations within the Austronesian language and cultural sphere, Taiwan and Palau share longstanding similarities in seafaring heritage, craftsmanship, and ecological knowledge.

In Taiwan, efforts to revitalize traditional maritime culture have resulted in the construction of hand-built canoes and bamboo rafts in Lanyu and Cidong, and the establishment of a Marine Learning Center in collaboration with the Cidong Indigenous community. These hubs serve as platforms for intergenerational transmission of navigation and boat-building skills.

The arrival of the Palauan crew will be marked by a traditional welcoming ceremony in Cidong, featuring Indigenous cuisine and ceremonial dance performances. Following this, the team will engage in hands-on exchanges with local communities, sharing techniques in pandanus weaving, betel nut sheath crafting, traditional fishing, and cultural storytelling.

Looking ahead, Taiwan plans to construct its own Austronesian voyaging canoe in Taitung, with the goal of sailing from Taiwan to Palau in the coming year—thus continuing this cultural cycle from construction to navigation, strengthening mutual ties, and fostering long-term collaboration across the Austronesian world.

AR + AI: Evolution from Tool to “Second Brain”

SHANGHAI, May 8, 2025 /PRNewswire/ — Dr. Qiu Xiaoling, CFO of JBD, has recently delivered a penetrating analysis of the MicroLED microdisplay and AR glasses ecosystem, illuminating how these once-independent frontiers are coalescing to redefine wearable AI. As AI evolves from merely being “smarter” toward truly “more attuned to you,” users increasingly expect an always-on digital assistant. AR glasses have emerged as the quintessential conduit for frictionless, context-aware interaction, and the ultra-compact MicroLED microdisplay has become the linchpin technology that turns the vision of lightweight, all-day wearable intelligence into daily reality.

In today’s era of breakneck technological progress, one will soon no longer need to hunch over a smartphone. Instead, a lightweight pair of glasses will deliver real‑time information, translation, environmental awareness, reasoning, and even anticipate one’s needs. This is no sci‑fi fantasy, but a tangible outcome of the convergence of AI and AR.

The fusion of AI and AR offers consumers a far more natural, convenient means of interaction and is catalyzing a revolution in smart wearable electronics. Meta’s CTO Andrew Bosworth has remarked, “The always‑on AI experience will allow smart glasses to replace the smartphone.” [1] The future is rapidly approaching.

1.    AI Foundation Models: Democratization and Personalized Intelligence

Large reasoning models have imbued AI with the ability to “think like a human”: beyond parsing surface text, they grasp context and logic, generating responses that mirror human cognition. This breakthrough has dramatically elevated baseline AI capability and is already proving invaluable in daily work.

DeepSeek is a striking example. By optimizing both algorithms and system architecture, it markedly boosts the pre‑training efficiency and the inference speed, slashing development time and cost. As a result, AI applications can now run on a far wider array of devices—including resource‑constrained mobile hardware—truly democratizing the technology.

As AI grows ever more powerful, the paramount question becomes how to harness it efficiently and effortlessly. Every user’s needs differ—text, images, video, code generation, and more. Multimodal foundation models that fuse diverse data types can deliver bespoke services to each user and satisfy that diversity of use cases.

Hence AI is evolving from “smarter” to “more attuned to you.” By continually analyzing behavioral data, AI systems perpetually refine performance and service, realizing genuine personalized intelligence and penetrating ever broader, deeper domains.

2.    The AllDay AI Assistant: From “Omnipotent” to “Omnipresent”

Input and output are equally crucial in AI interaction. Input is what you ask AI to analyze; output is the result—text, audio, images, or video. Today the PC remains the device through which most people engage AI, yet it is hardly the most natural interface.

An all‑day AI assistant supplies information and interaction anytime, anywhere, without reliance on a phone or PC. Voice mode in tools such as ChatGPT is now ubiquitous,   illustrating that AI’s flexibility should no longer be constrained by hardware form factor.

Chest‑pin or handheld products such as AI Pin and Rabbit R1 pursued greater flexibility, but market response was lukewarm. Beyond physical‑design shortcomings, a decisive factor was the lack of interaction convenience.

As AI grows “omnipotent,” the ideal paradigm is to issue commands and receive answers anytime, anywhere—for example, consulting a recipe or setting a virtual timer while your hands are busy in the kitchen. That demands an “always‑on” device that senses your needs.

While true‑wireless‑stereo (TWS) earbuds are popular, smart glasses clearly win on long‑wear comfort and functional integration. They also furnish AI with a visual display—enabling multimodal interaction no earbud can match. Cameras, microphones, and other sensors supply far richer data than a smartphone, fortifying support for multimodal AI. As Mark Zuckerberg notes, “Glasses are uniquely positioned to let people see what you see and hear what you hear.” [2]

3.    AR + AI: Redrawing the Frontiers of HumanMachine Collaboration

AI turns AR glasses into a personal assistant—and, ultimately, a “second brain.” They can recommend books or films based on your history and preferences. The Verge wrote of Android XR prototypes: “For that hour I felt like Tony Stark, and Gemini was my J.A.R.V.I.S.” [3]

The combination of AI and AR’s visual display lets devices even anticipate needs: reminding you of your hotel‑room number, translating a foreign menu, or highlighting the next tool during furniture assembly.

To make AR glasses the optimal AI carrier, however, designers must overcome the engineering hurdle of true all‑day ergonomics. Optical architecture drives form factor: many LCoS, DLP, or BirdBath solutions are simply too bulky for stylish everyday wear.

MicroLED micro‑displays are pivotal. Their tiny volume, high brightness, and low power draw enable lightweight AR designs. The smallest engine now measures 0.15 cm³ and weighs just 0.3 g. Powered by JBD’s MicroLED displays, Vuzix Z100 and OPPO Air Glass 2 look little different from conventional eyewear and weigh barely thirty grams—perfect for all‑day wear.

Extreme miniaturization is driving AR into mainstream view, while rapid AI iteration, always‑on connectivity, and seamless interaction embed smart glasses ever more deeply into daily life.

AR + AI is reshaping human‑world connectivity, ushering in the next generation of interaction, and evolving into a genuine “second brain” that promises unparalleled convenience and innovation.

AR, when fused with AI, is not merely redefining how we connect with the world; it is also forging a new stratum of human‑machine symbiosis and fast maturing into humanity’s “second brain.” By infusing everyday life with unparalleled convenience and disruptive innovation, this convergence propels us toward a future that is immeasurably smarter—and profoundly brighter.

References

  1. https://www.thesun.co.uk/tech/30695475/meta-orion-glasses-boz-andrew-bosworth-interview-ai
  2. https://www.theverge.com/24253481/meta-ceo-mark-zuckerberg-ar-glasses-orion-ray-bans-ai-decoder-interview
  3. https://www.theverge.com/2024/12/12/24319528/google-android-xr-samsung-project-moohan-smart-glasses
  4. https://www.evenrealities.com/products/g1-a

Penetrium™ Breaks Oncology Barriers: The Solution to Cold Tumors and Metastatic Cancer Unveiled at AACR 2025

  • Penetrium™ Achieves Historic Breakthrough
  • Overcoming Cold Tumor Failure and the Challenge of Metastatic Cancer in Immunotherapy and Antibody Therapy
  • Presented at AACR 2025, Chicago

CHICAGO, May 8, 2025 /PRNewswire/ — Hyundai Bioscience presented the results of its Penetrium™ combination preclinical studies at the 2025 American Association for Cancer Research (AACR) Annual Meeting, held in Chicago.

The studies established that the repeated failures of immunotherapy and antibody treatments in cold tumors are not primarily caused by genetic resistance, as traditionally believed, but by pseudo-resistance**—a physical failure of infiltration resulting from extracellular matrix (ECM) stiffening. For the first time, Penetrium™ has been shown to structurally overcome this barrier.

Correcting 80 Years of Misconception:  The Real Problem Is Not Genetic Mutations—It’s Pseudo-Resistance

For decades, the dominant theory behind cancer treatment failure centered around genetic mutations. 

However, Hyundai Bioscience’s latest findings show that the actual obstacle lies in stiffened ECM that prevents immune cells and antibodies from reaching the tumor core.

Penetrium™ remodels the ECM, restoring infiltration pathways and enabling effective drug and immune cell access—providing a fundamental solution to the cold tumor problem.

Penetrium™ + Immunotherapy: Exceptional Results in Triple-Negative Breast Cancer (TNBC) Models

① In a TNBC mouse model, Penetrium™ combined with anti-PD-1 therapy led to:

  • A 48.3% reduction in tumor burden compared to anti-PD-1 monotherapy,
  • Complete elimination of metastasis observed in the combination group, which remained present in the monotherapy group.

Significantly, necrosis was induced within 3 days of Penetrium™ administration, and necrotic areas continued to grow with repeated dosing**—a trend not observed in the control group.

② Penetrium™ + Antibody Therapy:  Complete Suppression of Lung Metastasis in a Metastatic Lung Cancer Model

In a metastatic lung cancer model:

  • Bevacizumab monotherapy showed only 33% metastasis suppression,
  • The Penetrium™ combination group recorded 0% lung metastasis at 100 mg/kg dosage.

Additionally, a marked decrease in MMP-9 and VEGF expression confirmed ECM normalization and the restoration of drug penetration routes at the molecular level.

③ Penetrium™ + Chemotherapy: Overcoming the Limitations of Paclitaxel

Paclitaxel monotherapy was found to paradoxically promote lung metastasis. 

However, when combined with Penetrium™, metastatic lesion areas were reduced by over 70–80% compared to controls.

Furthermore, suppression of MMP-9 and restoration of E-cadherin demonstrated that Penetrium™ not only enhances chemotherapy efficacy but also structurally blocks metastasis—without additional toxicity.

Validated in Naturally Occurring Canine Mammary Cancer Model:  Stronger Responses Observed in Metastatic Tumors

In a naturally occurring canine mammary cancer model:

  • The Penetrium™ + POLYTAXEL® combination reduced primary tumor volume by up to 38.7%, compared to 21.1% with monotherapy,
  • Metastatic lymph node lesions showed up to 78.99% tumor volume reduction.

Notably, metastatic lesions responded more strongly than primary tumors, challenging the long-standing notion that metastatic cancer is untreatable.

Proven Safety and Clinical Readiness

Penetrium™ was administered at less than 9% of the NOAEL dose established in a 13-week GLP-compliant toxicity study. 

Its safety has also been verified in humans during a Phase 2 COVID-19 trial using the same API, niclosamide.

These results confirm Penetrium™ is fully prepared for human clinical application.

Official Statement from Dr. Soo-Jung Kim, Head of Research

“Penetrium™ is the world’s first platform to structurally solve the infiltration failure that has caused repeated failure of immunotherapy and antibody therapy in cold tumors. 

Our combination study with immunotherapy exceeded expectations, and Hyundai Bioscience will soon initiate clinical trials of Penetrium™ combinations for both TNBC and metastatic lung cancer.” 

— Dr. Soo-Jung Kim, Head of Research, Hyundai Bioscience

Clinical Expansion Underway

Hyundai Bioscience is currently:

  • Conducting a Phase 1 trial for prostate cancer in South Korea,
  • Preparing an investigator-initiated trial for acute myeloid leukemia (AML) in France.

Penetrium™: Launching a Tumor-Agnostic Cancer Treatment Platform

Penetrium ECM Remodeling Therapy™ is evolving into a tumor-agnostic universal cancer treatment platform with applicability not only to TNBC and metastatic lung cancer, but also to pancreatic, gallbladder, ovarian cancers, and hematological malignancies such as AML.

This breakthrough research is the first to structurally resolve infiltration failure in cold tumors, while also proving that metastatic cancers can be effectively treated**—a historic achievement in oncology.

About Hyundai Bioscience

Hyundai Bioscience is a global biotech company dedicated to developing innovative therapeutics for cancer, viral diseases, and rare conditions.

Through Penetrium ECM Remodeling Therapy™, the company is opening a new era of universally applicable cancer treatment across all tumor types.

In the viral therapeutics space:

  • Hyundai Bioscience successfully completed a Phase 2 clinical trial for COVID-19 in Korea,
  • Is conducting a global Phase 2 dengue fever trial in Vietnam in collaboration with DNDi (Drugs for Neglected Diseases initiative),
  • And is developing influenza and avian influenza treatments in partnership with the NIH and global institutions.

Driven by its core belief that “There is no disease that cannot be treated,” Hyundai Bioscience continues to lead global innovation in cancer, antiviral, and rare disease therapeutics.