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EPWK Holdings Ltd. Announces Receipt of Nasdaq Delisting Notification Letter

XIAMEN, China, Nov. 25, 2025 /PRNewswire/ — EPWK Holdings Ltd. (Nasdaq: EPWK) (the “Company”), a company that connects businesses with great talents through innovative and efficient cloud-sourcing platforms, today announced that the Company received a letter (the “Notification Letter”) from the Listing Qualifications Staff (the “Staff”) of The Nasdaq Stock Market, LLC (“Nasdaq”) on November 20, 2025, notifying the Company that, since the Company has not yet filed its Form 20-F for the fiscal year ended June 30, 2025 (the “Filing”), it no longer complies with Listing Rule 5250(c)(1). As a result, the Staff has determined to delist the Company’s securities from The Nasdaq Stock Market.

Since the Company is already before Nasdaq Hearings Panel (the “Panel”) for its failure to comply with Listing Rule 5250(a)(1), the Company will have seven days, or until November 28, 2025, to request an extended stay request of any further delisting actions, pending a Panel decision or any extension the Panel would grant. 

About EPWK Holdings Ltd.

The Company connects businesses with outstanding talent through an innovative and efficient integrated crowdsourcing platform, providing creative transaction services for small and medium-sized enterprises and suppliers. The Company was founded by Guohua Huang, former chief reporter of Fujian Daily Press Group, and conducts its operations through its subsidiaries and contractual arrangements with the variable interest entity in China. For more information, please visit the Company’s website: www.epwk.com

Forward-Looking Statements

Certain statements in this announcement are forward-looking statements, including, but not limited to, the Company’s proposed offering. These forward-looking statements involve known and unknown risks and uncertainties and are based on current expectations and projections about future events and financial trends that the Company believes may affect its financial condition, results of operations, business strategy and financial needs, including the expectation that the offering will be closed. Investors can find many (but not all) of these statements by the use of words such as “approximates,” “believes,” “hopes,” “expects,” “anticipates,” “estimates,” “projects,” “intends,” “plans,” “will,” “would,” “should,” “could,” “may” or other similar expressions. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to review other factors that may affect its future results in the Company’s registration statement and other filings with the SEC.

UNIDO Announces Winners of Inaugural One World Sustainability Awards in Riyadh

RIYADH, Saudi Arabia, Nov. 25, 2025 /PRNewswire/ — UNIDO has announced the winners of the inaugural ONE World Sustainability Awards at the twenty-first session of the UNIDO General Conference (GC21) in Riyadh, Saudi Arabia, celebrating innovators whose work advances sustainable, inclusive industrial development across the globe.

UNIDO Director General with the winners of the inaugural ONE World Sustainability Awards at GC21 in Riyadh
UNIDO Director General with the winners of the inaugural ONE World Sustainability Awards at GC21 in Riyadh

H.E. Vice Minister of Industry and Mineral Resources for Industrial Affairs of Saudi Arabia, Eng. Khalil bin Ibrahim bin Salamah, emphasized the transformative power of the awards: “These awards send a clear message to the world. They show that profitability and positive impact can thrive side by side and that sustainability is no longer a choice but a powerful economic drive.”

UNIDO Director General highlighted in his opening speech that: “This is the beginning of a movement where sustainability is not an option but a standard. The winners show us that innovation, responsibility and success can go hand in hand. The choices we make today – how we produce and how we consume – impact our societies today and tomorrow. Together we can shape a future that is fair, sustainable, and full of opportunities for all.”

Launched as part of the Global Industry Summit 2025, the awards honor individuals and organizations across four categories: Innovative Startups, Sustainable Supply Chains, Women in Industry, and Lifetime Achievement.

Nature Bio Foods, represented by Amit Singh, received the Sustainable Supply Chains Award. The India-based company works with more than 96,000 smallholder farmers across India, Africa, and Europe, pioneering climate-resilient, carbon-neutral agriculture models.

The Women in Industry Award was presented to Norah Magero, CEO of Drop Access Limited in Kenya, recognized for advancing solar-powered cold-chain innovation that supports vaccine distribution and food systems across Africa.

WeLight Africa, led by Romain De Villeneuve, won the Innovative Start-ups Award for accelerating rural electrification through sustainable mini-grid solutions in Madagascar, Mali, Nigeria and the Democratic Republic of Congo.

Dr. Gro Harlem Brundtland of Norway received the Lifetime Achievement Award as the country’s first female Prime Minister and former WHO Director-General.

“The scale of UNIDO here in Riyadh inspires us to advance our cold-chain innovations and deepen Drop Access’s impact for the communities that need them most,” said Norah Magero.

Media contact: 
For more information
Ahmed Mansour
M +966 54 186 9849
E ahmed.mansour@omc.com

FROM MEDICAL SUPPLIER TO MULTI-INDUSTRY LEADER: LIVINGSTONE INTERNATIONAL’S UNIQUE GROWTH STRATEGY

SYDNEY, Nov. 25, 2025 /PRNewswire/ — One of Australia’s largest medical supply companies is celebrating its unique warehousing and supply chain strategy that has seen it grow into a leading manufacturer, importer, and supplier to more than 20 key industries.

'One of seven Livingstone warehouses driving Australia’s most reliable supply network.'
‘One of seven Livingstone warehouses driving Australia’s most reliable supply network.’

Livingstone International supplies more than 65,000 essential health, hygiene, education, beauty, and hospitality products to industries including aged care, schools and universities, hair and skin clinics, pharmacy, dental, mining, and government.

Livingstone International Managing Director, Daniel Linn, said the company has now been in operation for more than 40 years and its success rests on its unique No Backorder Policy.

“Livingstone International has invested in millions of cubic metres of warehousing here in Australia, where we can hold up to a year’s worth of supplies for each of our key clients.”

“Livingstone stocks more than $48 million dollars’ worth of inventory. Our depth of inventory and domestic warehousing means there’s no disruption to the supply chain, which is critical for the industries we work with,” Mr Linn said.

It’s a lesson that was learned during COVID, when many organisations and government turned to Livingstone for key supplies.

“The reality is much of what we rely on in Australia is manufactured overseas and imported. That process often requires a two to three month waiting period before products arrive.”

“At Livingstone, we have the stock here in Australia ready to distribute, while also locally manufacturing 120 products, to ensure they’re there for when our clients need them,” he said.

Livingstone remains proudly Australian owned, with an international footprint across 120 countries.

“When Livingstone was founded in 1984, we focused on medical and healthcare supplies, but we’ve now undergone major diversification,” Mr Linn said.

“The rationale for expansion was: if we can supply products to people when they are unwell, why not also offer items for when they are well? The goal was to meet needs 365 days a year and this approach became a guiding principle for determining which industries to branch into.

“Among our 25,000 customers are 149 major public hospitals which depend on Livingstone for kitchen supplies, 22 airlines in which we’re involved with food prep, a pathology market leader with more than 500 delivery points, and we supply lab equipment and coats to the biggest mining company in the country.”  

Mr Linn said while this year marks a major milestone, the future is full of opportunity.

“We’re already adopting some of the latest technology in automation and AI, we are diversifying our supply chain across multiple countries, and our IT infrastructure is already driving greater growth across our B2C market,” he said.

“We look forward to continuing to help secure Australia’s supply chain and provide essential services and key industries with the products they need to serve Australians every day.”

EcoFlow and Go Solar Australia Announce Strategic Partnership to Expand High-Performance Residential Battery Solutions Across Australia

SYDNEY, Nov. 25, 2025 /PRNewswire/ — EcoFlow, a global innovator in residential energy storage and smart home energy ecosystems, has formally partnered with Go Solar Australia to expand the availability of EcoFlow’s advanced home battery systems to solar retailers, installers and engineering partners nationwide.


With demand surging for reliable residential storage solutions that address rising energy costs, grid instability and the need for flexible solar-integration options, the partnership delivers significant commercial benefits to the Australian solar and storage sector.

The collaboration leverages Go Solar Australia’s extensive distribution, warehouse and installation network – providing trade professionals with streamlined access to EcoFlow’s high-efficiency LFP PowerOcean battery systems, scalable storage modules, and intelligent home energy-management technology.

Key Advantages for Installers & Industry Partners

  • Superior engineering & safety 
    EcoFlow’s PowerOcean is built around durable LFP chemistry, recognised for its thermal stability and low risk of thermal runaway. Each battery module includes a dedicated fire-prevention system with multi-layer thermal insulation, temperature monitoring and automatic shut-off mechanisms designed to isolate abnormal conditions before escalation. The system is housed in an IP65-rated enclosure, protecting components from dust, rain and harsh outdoor environments commonly encountered in Australian installations. Together, these measures support safe installation, long-term reliability and user confidence.
  • Expanded product portfolio
    Installers gain access to EcoFlow’s growing residential storage ecosystem – engineered for fast installation, modular expansion up to 180kWh and system-wide safety.
  • Flexible system design
    Scalable capacity allows installers to serve diverse residential use cases – from small urban homes to high-demand family properties.
  • Local supply chain support
    Backed by Go Solar Australia’s multi-state warehouses, technical support and national installer base.
  • Third-party compatibility 
    PowerOcean integrates smoothly with a wide range of third-party inverters, rooftop solar systems, smart thermometers and home-energy devices. This gives installers the flexibility to pair EcoFlow storage with both new builds and existing residential setups without limiting system design options.
  • Smart energy optimisation 
    PowerOcean’s onboard energy-management capabilities continually analyse household consumption, solar production and tariff patterns to optimise charging and discharging automatically. This ensures installers can deliver systems that maximise self-consumption, improve overall efficiency and reduce long-term energy costs for homeowners.

“Our partnership with Go Solar Australia unlocks new opportunities for solar retailers and installers seeking high-quality, fast-to-deploy and future-proof residential energy systems,” said, EcoFlow Craig Bilboe, Country Manager, Australia & New Zealand. “EcoFlow is committed to supporting the Australian solar industry with premium technology, strong warranties and excellent local support.”

“EcoFlow’s offerings are a natural fit for our installer network,” said Lewis Sheppard, National Sales Director of Go Solar Australia. “The systems are reliable, scalable and engineered for professional installation – exactly what our trade partners look for. We’re proud to help accelerate EcoFlow’s growth in the Australian market.”

About EcoFlow

EcoFlow is a global leader in eco-friendly energy solutions, committed to powering a sustainable future. Since its founding in 2017, EcoFlow has focused on creating flexible, innovative, and reliable power solutions for homes, outdoor adventures, and on-the-go lifestyles. With headquarters in the USA, Germany, and Japan, EcoFlow has empowered over 5 million users across 140 markets worldwide.

About Go Solar Australia

Go Solar Australia is a leading national provider of solar and battery engineering, installation and wholesale services, supporting trade partners in delivering reliable and efficient renewable energy systems across the country.

Fisher Investments Recognised as a Great Place to Work®

Fisher Investments was certified by global authority on workplace culture

SYDNEY, Nov. 25, 2025 /PRNewswire/ — Fisher Investments Australia and its US-based parent company, Fisher Investments, were certified by Great Place to Work®, an independent, global authority on workplace culture and employee experience.

Great Place to Work® certifies companies based on anonymous employee survey results across key factors including compensation, benefits, career advancement opportunities, competence of management and overall workplace atmosphere. Survey feedback revealed Fisher Investments Australia employees believe the company provides a fair, welcoming and service-focused work environment.

“We are incredibly proud of this recognition from Great Place to Work®,” said Fisher Investments’ CEO Damian Ornani, adding, “This honour highlights our dedication to fostering a culture where employees feel valued, motivated and empowered to thrive. We know that by investing in our people and their growth, we create a stronger foundation to deliver exceptional service and help more clients reach their financial goals.”

Fisher Investments and its affiliates are hiring for a variety of roles globally. Visit FisherCareers.com to learn more about career opportunities. For more details on the Great Place to Work® certification process, please visit www.greatplacetowork.com.au/our-methodology.

About Fisher Investments Australia®
Fisher Investments Australia® is a trademark of Fisher Investments Australasia Pty Ltd (ABN 86 159 670 667, AFSL 433312), which provides services to wholesale clients only and outsources portfolio management to its parent company, Fisher Asset Management, LLC (AR 001292046), which does business in the United States as Fisher Investments. Fisher Investments Australasia Pty Ltd was established in 2013 and is based in Sydney. For more information on Fisher Investments Australia, please visit https://www.fisherinvestments.com/en-au.

About Fisher Investments
Fisher Investments is an independent, fee-only investment adviser. As of 30/09/2025, Fisher Investments and its subsidiaries manage over A$547 billion across three principal businesses—Institutional, US Private Client and Private Client International. Founder and Executive Chairman Ken Fisher wrote the Forbes “Portfolio Strategy” column for over 32 years until 31/12/2016, making him the longest continuously running columnist in the magazine’s history. He now writes monthly, native language columns in 27 major media organs around the world—including the Australian Financial Review—spanning more countries and more languages in more total reach than any other, non-syndicated columnist of any type ever. Ken appears regularly on major TV news like Fox Business and News, BBC, Sky News, BNN Bloomberg and CNN International. Ken has written 11 investing and finance books, including four New York Times bestsellers. For more information about Fisher Investments, visit www.fisherinvestments.com.

Media Contacts

Great Place to Work Certified Sep. 2025 - Sep. 2026
Great Place to Work Certified Sep. 2025 – Sep. 2026

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SOLO LEVELING: ARISE OVERDRIVE LAUNCHES TODAY ON STEAM AND XBOX PC

Launch Trailer Drops, Featuring Sung Jinwoo’s Ascension to Become the Ultimate Monarch of Shadows

SEOUL, South Korea, Nov. 25, 2025 /PRNewswire/ — Solo Leveling: ARISE OVERDRIVE, developed by Netmarble Neo and published by Netmarble, is available now on Steam and Xbox PC, with a new trailer to celebrate its official release.

Based on the worldwide megahit webtoon Solo Leveling, this action RPG delivers an original take on a beloved adventure that fans have been waiting for. Complete with gorgeously animated combat, deep progression systems, and dynamic battles, the game brings to life the story of Hunter Sung Jinwoo, who rises from humble beginnings to become the world’s strongest hunter – the Ultimate Shadow Monarch.

First showcased to fans at TwitchCon San Diego last month to an enthusiastic reception, Solo Leveling: ARISE OVERDRIVE has built momentum through the demo release on November 17 and Advanced Access that began on November 21. Now, the game is officially available worldwide, inviting all players to become Sung Jinwoo themselves. 

Through Story Mode, players will be able to create their own perfect version of Sung Jinwoo, customizing his appearance, skills, and playstyle as they unleash their ultimate power. By recruiting Hunters to fill out their ranks and battling bosses in 4-player co-op raids, players will be able to strengthen their teams and showcase their skills across the game’s many challenges.

Solo Leveling: ARISE OVERDRIVE is available now on Steam and Xbox PC for $39.99

Visit the official website and Steam page, and follow the game’s channels on Twitch, YouTube and Discord, for more information, or wishlist the game on Xbox.

About Netmarble Corporation

Founded in Korea in 2000, Netmarble Corporation is a leading global game developer and publisher. Through acclaimed franchises and strategic partnerships with top-tier IP holders, the company delivers innovative and engaging gaming experiences to audiences worldwide. As a parent company of Kabam, SpinX Games, Jam City, and a major shareholder of HYBE and NCSOFT, Netmarble’s diverse portfolio includes Solo Leveling: ARISE, Seven Knights Re: BIRTH, Raven2, MARVEL Future Fight, and The Seven Deadly Sins: Grand Cross. More information can be found at http://company.netmarble.com.

 

Aramco and Pasqal make history with Saudi Arabia’s first quantum computer

  • Companies announce first quantum computer in the Middle East dedicated to industrial applications
  • Technological milestone will accelerate development of quantum applications in the energy, materials and industrial sectors
  • Deployment builds on Aramco’s advanced digital capabilities, with potential to further elevate operations and unlock additional value
  • Pasqal strengthens its position as a global leader with delivery of the first neutral-atom quantum computer in the region

DHAHRAN, Saudi Arabia, Nov. 25, 2025 /PRNewswire/ — Aramco, one of the world’s leading integrated energy and chemicals companies, in partnership with Pasqal, a global leader in neutral-atom quantum computing, have achieved a major breakthrough for the Middle East’s technology landscape with the successful deployment of Saudi Arabia’s first quantum computer — and the region’s first quantum computer dedicated to industrial applications.

The deployment of Pasqal’s quantum computer powered by neutral-atom technology at Aramco’s data center, in Dhahran, marks a pivotal step in building regional expertise and accelerating the development of quantum applications across the energy, materials, and industrial sectors in the Kingdom of Saudi Arabia and the broader Middle East.

It aligns with Aramco’s strategy to leverage advanced digital technologies to enhance operational efficiency, accelerate innovation and create long-term value. It also reflects Pasqal’s global mission to deliver practical, industry-ready quantum solutions to strategic sectors worldwide.

Ahmad O. Al-Khowaiter, Aramco EVP of Technology & Innovation, said: “Aramco is an established technology leader, which continues to innovate through the development and deployment of advanced digital solutions that have tangible benefits. We are deploying AI and other technologies at scale to further enhance our operations, maximize efficiency and unlock value across our business. Our partnership with Pasqal is a natural progression and we are thrilled to pioneer next-generation quantum capabilities, harnessing significant opportunities presented by this new frontier in computing.”

Loïc Henriet, Pasqal CEO, said: “This is a historic milestone with Aramco. The deployment of our most powerful quantum computer yet is a piece of history and a landmark for the Middle East’s quantum future. Pasqal continues its expansion, delivering practical quantum power to industry.”

Wa’ed Ventures, part of Aramco’s venture capital program, initially invested in Pasqal in January 2023, making it one of the company’s early strategic investors. Since then, Wa’ed Ventures has actively supported Pasqal’s efforts to localize its technologies and operations in Saudi Arabia, enabling the company to build a strong presence in the Kingdom and contribute to the development of a regional quantum ecosystem.

Pasqal’s system installed at Aramco’s data center can control 200 qubits arranged in programmable two-dimensional arrays, offering a platform suitable for exploring advanced quantum algorithms and real-world use cases relevant to industrial operations.

As part of the partnership, Pasqal will also provide training programs and joint research opportunities for Saudi engineers and scientists, strengthening the Kingdom’s quantum ecosystem and supporting the development of high-tech talent.

X @aramco

About Aramco

As one of the world’s leading integrated energy and chemicals companies, our global team is dedicated to creating impact in all that we do, from providing crucial oil supplies to developing new energy technologies. We focus on making our resources more dependable, more sustainable and more useful, helping to promote growth and productivity around the world. https://www.aramco.com

About Pasqal

Pasqal is a leading Quantum Computing company that builds quantum processors from ordered neutral atoms in 2D arrays to bring a practical quantum advantage to its customers and address real-world problems. Pasqal was founded in 2019, out of the Institut d’Optique, by Georges-Olivier Reymond, Christophe Jurczak, Professor Dr. Alain Aspect, Nobel Prize Laureate Physics, 2022, Dr. Antoine Browaeys, and Dr. Thierry Lahaye. Pasqal has secured more than €140 million in financing to date.  To learn more about us, visit www.pasqal.com.

Disclaimer
The press release contains forward-looking statements. All statements other than statements relating to historical or current facts included in the press release are forward-looking statements. Forward-looking statements give the Company’s current expectations and projections relating to its capital expenditures and investments, major projects, upstream and downstream performance, including relative to peers. These statements may include, without limitation, any statements preceded by, followed by or including words such as “target,” “believe,” “expect,” “aim,” “intend,” “goal,” “may,” “anticipate,” “estimate,” “plan,” “project,” “can have,” “likely,” “should,” “could,” and other words and terms of similar meaning or the negative thereof. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors beyond the Company’s control that could cause the Company’s actual results, performance or achievements to be materially different from the expected results, performance, or achievements expressed or implied by such forward-looking statements, including the following factors: global supply, demand and price fluctuations of oil, gas and petrochemicals; global economic conditions; competition in the industries in which Saudi Aramco operates; climate change concerns, weather conditions and related impacts on the global demand for hydrocarbons and hydrocarbon-based products; risks related to Saudi Aramco’s ability to successfully meet its ESG targets, including its failure to fully meet its GHG emissions reduction targets by 2050; conditions affecting the transportation of products; operational risk and hazards common in the oil and gas, refining and petrochemicals industries; the cyclical nature of the oil and gas, refining and petrochemicals industries; political and social instability and unrest and actual or potential armed conflicts in the MENA region and other areas; natural disasters and public health pandemics or epidemics; the management of Saudi Aramco’s growth; the management of the Company’s subsidiaries, joint operations, joint ventures, associates and entities in which it holds a minority interest; Saudi Aramco’s exposure to inflation, interest rate risk and foreign exchange risk; risks related to operating in a regulated industry and changes to oil, gas, environmental or other regulations that impact the industries in which Saudi Aramco operates; legal proceedings, international trade matters, and other disputes or agreements; and other risks and uncertainties that could cause actual results to differ from the forward-looking statements in this press release, as set forth in the Company’s latest periodic reports filed with the Saudi Exchange. For additional information on the potential risks and uncertainties that could cause actual results to differ from the results predicted please see the Company’s latest periodic reports filed with the Saudi Exchange. Such forward-looking statements are based on numerous assumptions regarding the Company’s present and future business strategies and the environment in which it will operate in the future. The information contained in the press release, including but not limited to forward-looking statements, applies only as of the date of this press release and is not intended to give any assurances as to future results. The Company expressly disclaims any obligation or undertaking to disseminate any updates or revisions to the press release, including any financial data or forward-looking statements, whether as a result of new information, future events or otherwise, unless required by applicable law or regulation. No person should construe the press release as financial, tax or investment advice. Undue reliance should not be placed on the forward-looking statements.

HKeyBio Launches the HKEY-AIDMD 3.0–a Next-Generation Platform to Crack the Toughest Challenge in Autoimmune and Allergy Drug Development: Multi-target Combination Strategy Optimization

  • The newly upgraded HKEY-AIDMD 3.0 model library features nearly 300 autoimmune and allergy-related disease models. For multiple major indications, HKeyBio has established four-dimensional (4D) model pools that simulate clinical heterogeneity, providing a mechanism-driven model selection platform for evaluating multi-target combination therapies.
  • The HKEY-AIDMD 3.0 omics database integrates spatiotemporal single-cell and spatial omics across various tissues and immune systems from the model library. This significantly improves resolution in identifying the differentiating advantages of multi-target combinations—uncovering subtle distinctions across genes, molecules, cells, tissues, and clinical phenotypes.

BOSTON and SUZHOU, China, Nov. 25, 2025 /PRNewswire/ — HKeyBio, a global leading CRO specializing in preclinical and translational research for autoimmune and allergic disease drug development, has officially launched the upgraded HKEY-AIDMD 3.0 platform. This platform includes: (1) a four-dimensional model library of nearly 300 autoimmune and allergic disease models, and (2) a comprehensive spatiotemporal single-cell and spatial omics database derived from these models. The platform is designed to significantly enhance prediction accuracy for clinical translation of multi-target combination therapies.

HKEY-AIDMD 3.0
HKEY-AIDMD 3.0

Autoimmune and allergic diseases stem from dysregulated immune networks across three major immunological domains: multiple cellular components, diverse cytokine networks, and interconnected signaling pathways. These conditions involve aberrant activity of immune cell populations such as T cells, B cells, dendritic cells, and granulocytes; dysregulated cytokines including IL-6, IL-4, TNF; and perturbed signaling pathways such as JAK/STAT, NF-κB, BTK, along with mechanisms of immune tolerance. Since single-target drugs may demonstrate limited efficacy in certain patient populations, multi-target combinations can more comprehensively modulate pathological networks and improve therapeutic outcomes. Moreover, due to disease heterogeneity, multi-target therapies can more precisely match patient-specific pathogenic profiles, supporting personalized treatment strategies.

However, multi-target drug development faces major technical and clinical challenges. The number of possible combinations increases exponentially due to the diversity of targets, dosing regimens, and mechanisms of action. With limited resources, prioritizing the most effective and safest combinations is an urgent unmet need. Achieving optimal combinations requires accurate mapping of key pathogenic nodes within disease networks and identifying predictive biomarkers for treatment response.

HKeyBio’s newly upgraded HKEY-AIDMD 3.0 provides a practical solution to the “optimal multi-target combination” challenge. Built upon deep mechanistic insights into autoimmune and allergic diseases, HKeyBio has developed four-dimensional model pools across multiple species, strains, and induction strategies to simulate various disease subtypes and endotypes. These model pools enable evaluation of in vivo interactions, feedback mechanisms, and synergy of multi-target combinations. Using systems biology approaches, including gene regulatory networks, protein-protein interaction networks, and pathway topology analysis, HKeyBio identifies key nodal and bottleneck targets in disease networks. Machine learning methods further support predictive modeling of combination outcomes and discovery/validation of biomarkers such as gene signatures, single-cell immune profiles, and cytokine panels.

The HKEY-AIDMD 3.0 platform not only enhances predictive value for multi-target efficacy but also significantly boosts developability and commercial partnering value. By integrating multi-indication 4D model pools with spatiotemporal omics, the platform offers critical support for new drug development in rheumatology, immunology, and allergy. It improves mechanistic accuracy, provides high-resolution multi-dimensional biomarker discovery, and increases reliability in predicting therapeutic responses across multiple pathways.

About the HKeyBio HKEY-AIDMD 3.0 Platform

The HKEY-AIDMD 3.0 model library covers nearly 300 autoimmune and allergy-related disease models. For major indications, HKeyBio has built 4D model pools that simulate clinical heterogeneity to support mechanism-based model selection for multi-target combination evaluation. These include dermatologic models (atopic dermatitis, urticaria, pruritus, hidradenitis suppurativa, psoriasis), respiratory models (asthma, COPD, pulmonary fibrosis), gastrointestinal models (IBD, Crohn’s disease), and rheumatologic models (SLE, cutaneous lupus, Sjögren’s syndrome, rheumatoid arthritis, systemic sclerosis, multiple sclerosis), among many others.

The HKEY-AIDMD 3.0 omics database encompasses spatiotemporal single-cell and spatial omics across tissues and immune compartments from all models. Using systems biology methods—including gene expression networks, protein–protein interaction networks, and signaling topology analysis—combined with machine learning, the platform predicts multi-target drug combination effects and validates biomarkers for efficacy and safety, dramatically improving the resolution in differentiating target-combination strategies.

HKeyBio is an industry-leading CRO specializing in pharmacology and translational research for autoimmune diseases—focused, dedicated, and deeply experienced in autoimmune innovation.
For more information, please visit www.hkeybio.com

For inquiries, please contact: us.bd@hkeybio.com