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Visionary Holdings Inc. 2025 Annual General Meeting Concludes Successfully: Completes Board Renewal, Anchors New Direction for Compliant Development

TORONTO, Oct. 31, 2025 /PRNewswire/ — Visionary Holdings Inc. (hereinafter referred to as the “Company”; a diversified enterprise registered in Ontario, Canada and listed on the Nasdaq Capital Market under the ticker symbol: GV) successfully held its 2025 Annual General Meeting (AGM) via Zoom video conference from 10:00 a.m. to 12:00 p.m. ET (UTC-4) on the same day. Chaired by Mr. Robert Jay LEES, the voting rights represented by attending shareholders and their proxies accounted for 97.79% of the company’s total voting rights, far exceeding the quorum requirements stipulated in the Business Corporations Act (Ontario, 1990), Nasdaq Listing Rules, and the company’s Articles of Association. The meeting’s convening procedures and agenda items were in compliance with laws and regulations, fully safeguarding shareholders’ rights to participation and voting.

During the meeting, shareholders and their proxies conducted in-depth discussions on core agenda items including board renewal, reappointment of auditors, and review of the annual report. Eventually, all proposals were approved with an overwhelming majority, laying a solid institutional foundation for the company’s governance enhancement and business layout in the next fiscal year.

I. Renewal of the 4th Session of the Board of Directors: Professional Team to Support Strategic Implementation

As the core agenda of this meeting, the Company strictly adhered to the U.S. SEC’s director independence standards and Nasdaq’s mandatory rule of “a majority of independent directors (≥50%)”. The Nomination Committee, through public solicitation and multiple rounds of interview evaluations, selected 16 qualified candidates (including 9 incumbents and 7 new members) from 18 candidate profiles, covering key fields such as corporate management, financial management, legal compliance, international education, high-end medical aesthetics and big health, and biotechnology.

Based on the statistics from the dual voting mode of “on-site voting + email voting”, 9 candidates – Mr. William T. Chai, Mr. Kealey Donald M, Mr. Jun Huang, Mr. Rusheng Wu, Mr. Robert Jay LEES, Ms. Jiena Zhang, Mr. Weixing Wang, Mr. Yi Wang and Mr. Henry Sun – were officially elected as members of the 4th Session of the Board of Directors, having received more than two-thirds of the affirmative votes from the valid voting rights of attending shareholders. Their term will run from the effective date of the resolution of this AGM to the end of the 2026 Annual General Meeting.

With their cross-sector professional backgrounds and rich practical experience, the new board members will provide diverse perspectives for the company’s strategic decision-making, further optimize the governance structure, and effectively safeguard the long-term interests of all shareholders.

II. Reappointment of Auditors: Strengthening the Defense Line of Financial Compliance

To meet the stringent audit supervision requirements of the U.S. SEC and Nasdaq for listed companies, the meeting approved the Proposal on the Appointment of Auditors for the 2025-2026 Fiscal Year, agreeing to reappoint Assentsure PAC as the company’s auditor for the 2025-2026 fiscal year (April 1, 2025 to March 31, 2026).

Assentsure PAC has completed registration with the U.S. Public Company Accounting Oversight Board (PCAOB) and holds the legal qualification to provide audit services for U.S.-listed companies. During the 2024-2025 fiscal year audit work, its core team, supported by over 6 years of cross-border audit experience, efficiently completed the financial statement audit and internal control evaluation. The audit conclusions truly reflected the company’s financial status, and its professional capabilities have been recognized by the company and shareholders. After this reappointment, Assentsure PAC will continue to be responsible for statutory matters such as the company’s annual financial statement audit and SEC periodic report audit. The audit service fee will remain consistent with the previous fiscal year (excluding audit travel expenses and fees for additional matters), ensuring that the company’s financial information disclosure is “true, accurate, complete, timely and fair”.

III. Review of Annual Reports: Clarifying Operating Results and Development Path

The meeting approved the 2024-2025 Fiscal Year Financial Report and 2024-2025 Fiscal Year Board of Directors’ Work Report with an overwhelming majority, conducting a comprehensive review of the company’s operating performance and strategic progress in the past fiscal year (April 1, 2024 to March 31, 2025):

Financial Performance: The revenue of the company’s core businesses (real estate, education, and big health) accounted for 78%. The net profit of the new business (big health projects) achieved a year-on-year growth of 100%, demonstrating remarkable results in business transformation. Total assets remained stable at USD 68,792 thousand, and the asset-liability ratio was controlled at 80%, maintaining a sound financial structure and providing sufficient resilience for future development.

Business and Governance Progress: On the market front, the company established branches in China, added more than 30 new clients, maintained customer satisfaction at over 80%, and continuously enhanced its international brand influence. On the strategic front, it deployed in the fields of artificial intelligence and big health, completed the acquisition of the Changle Shuang Big Health Project and the strategic investment in the new energy vehicle project, expanding its growth tracks. On the governance front, it revised the Articles of Association and Rules of Procedure for the Board of Directors, strengthened internal control and risk management, and further improved its compliant operation capabilities.

The reports clearly stated that in the next fiscal year, the company will focus on three major goals: “improving the quality of core businesses, accelerating the development of emerging businesses, and strengthening compliant governance”, increase R&D investment and talent development, and promote high-quality business development.

IV. Confirmation of Statutory Matters: Consolidating the Foundation for Compliant Operations

To ensure the legality and continuity of the company’s governance, the meeting reviewed and approved three key statutory matters:

1.Confirmed the legality and validity of the election results for the 4th Session of the Board of Directors, verifying that the qualifications of the new board members comply with the requirements of laws, regulations and the company’s Articles of Association;

2.Confirmed the validity of the appointment of Assentsure PAC as the company’s auditor for the 2025-2026 fiscal year, and clarified its audit responsibilities and service scope;

3.Approved the 2024-2025 Fiscal Year Form 20-F, ensuring that the annual report submitted by the company to the U.S. SEC complies with information disclosure regulatory requirements.

V. Follow-up Arrangements: First Meeting of the 4th Session of the Board of Directors to Be Held Soon

In accordance with the resolution of this AGM, the first meeting of the 4th Session of the Board of Directors will be held via Zoom video conference at 10:00 a.m. on November 3, 2025 (ET). The core agenda will include: electing the Chairman of the Board, Executive Directors, and Secretary of the Board; determining the members of the four special committees (Audit, Nomination, Remuneration, and Investment); and appointing the senior management team including CEO, Co-CEO, CFO, and Vice Presidents. The relevant meeting resolutions will be disclosed through the “Investor Relations” section on the company’s official website (www.visionary.holdings) within 48 hours after the meeting, ensuring that shareholders are promptly informed of the company’s governance developments.

The Board of Directors of Visionary Holdings Inc. stated: “The successful convening of this Annual General Meeting has injected new governance momentum into the company. The 4th Session of the Board of Directors will take ‘being responsible to shareholders and seeking development for the company’ as its core, diligently perform its duties, deepen business innovation on the basis of compliant operations, continuously enhance the company’s core competitiveness, and create long-term and stable value returns for all shareholders.”

 

JoyLogistics Launches Integrated Delivery and Installation Service for Bulky Items in Malaysia and Singapore

SINGAPORE, Oct. 31, 2025 /PRNewswire/ — JoyLogistics, the supply chain solutions arm of JINGDONG Logistics (JD Logistics), announced the launch of its integrated delivery and installation service for bulky items in Malaysia and Singapore. In the core areas of Kuala Lumpur, a next-day delivery service can be provided upon appointment.

Delivering bulkier home appliances or furniture can be more complex than handling standard parcels, with orders often requiring in-home placement or professional installation.

To address these challenges and ensure a high standard of customer experience, JD Logistics is offering businesses an integrated one-stop delivery and installation logistics solution. The service provides end-to-end support from doorstep delivery and installation to on-site setup, all completed in a single visit. Customers can also request doorstep returns and exchanges, ensuring a seamless, reliable, and worry-free experience.

Leveraging its global logistics network, JoyLogistics also provides enterprises with comprehensive 3PL services, including cross-border transportation, local warehousing, outbound fulfillment, last-mile delivery and installation, and reverse logistics.

As the supply chain and logistics arm of JD.com, JINGDONG Logistics has become a world-leading integrated supply chain and logistics service provider. It operates over 3,600 warehouses and can deliver 95% of first-party orders within 24 hours in China. JINGDONG Logistics has established a warehouse-centered global logistics network. To date, the company operates nine overseas warehouses across Southeast Asia, covering Malaysia, Thailand, Singapore, Vietnam, and Indonesia. Within local warehouse cities, it provides same-day and next-day delivery, while cross-border shipments can arrive in as fast as 72 hours.

To further enhance its international capabilities, JINGDONG Logistics is expanding its warehousing, air freight, and express delivery networks across Southeast Asia, empowering businesses and consumers throughout ASEAN with faster, more reliable, and fully integrated logistics solutions.

About JINGDONG Logistics

JINGDONG Logistics (HKEX: 2618), also known as JD Logistics, is a leading technology-driven supply chain solutions and logistics services provider. JINGDONG Logistics has established six highly synergized logistics networks including warehousing, line-haul transportation, last-mile delivery network, bulky items, cold chain logistics, and cross-border logistics networks. Including cloud warehouses operated by third parties, JINGDONG Logistics manages over 3,600 warehouses, with a total area exceeding 34 million square meters. The company currently operates over 130 bonded, direct mail and overseas warehouses, with a total GFA exceeding 1 million square meters, spanning 23 countries and regions worldwide. “JoyLogistics” and “JoyExpress” are JINGDONG Logistics’ international business brands.

 

Abu Dhabi Royal Equestrian Arts, the World’s Fifth School of Classical Horsemanship, Officially Opens Its Doors

ABU DHABI, UAE, Oct. 31, 2025 /PRNewswire/ — In a landmark moment for the region and the UAE, Abu Dhabi Royal Equestrian Arts (ADREA), the world’s fifth school of classical horsemanship and the first of its kind established outside Europe, has officially opened its doors on Jubail Island in Abu Dhabi. Set within a tranquil landscape surrounded by mangroves and minutes from the city’s heart, the school invites guests to embark on an inspiring journey into the art of classical horsemanship.

Royal Gala of Abu Dhabi Royal Equestrian Arts
Royal Gala of Abu Dhabi Royal Equestrian Arts

On the evening of October 30, the grand opening welcomed distinguished guests, dignitaries and members of the equestrian community, who were among the first to witness the inaugural performance, a mesmerizing tribute to historic craftsmanship, classical horsemanship and the profound connection between horse and rider.

The opening of ADREA marks a defining cultural milestone for Abu Dhabi, introducing a world-class destination where the artistry of horse and rider takes center stage. Visitors can now experience weekly live performances that merge equestrian mastery with music and choreography, bringing audiences closer to the roots of Furusiyya, the ancient tradition of horsemanship that embodies skill, discipline and harmony.

For the first time in history, all five classical schools of horsemanship from Austria, Spain, Portugal, France and now the UAE came together at Abu Dhabi Royal Equestrian Arts in a spectacular showcase representing centuries of artistry, mastery and cultural tradition. The Spanish Riding School presented its renowned Lipizzaner stallions in the iconic Ballet of the White Stallions. The Royal Andalusian School of Equestrian Arts showcased the passion and rhythm of Andalusia’s dancing horses. The Portuguese School of Equestrian Art displayed the precision and elegance of the Lusitano horse, while the Cadre Noir de Saumur performed its unique expression of haute école horsemanship and performance art. Completing this extraordinary line up, Abu Dhabi Royal Equestrian Arts presented its own ensemble of riders and horses, establishing the UAE’s first permanent home for classical horsemanship and blending Emirati heritage with timeless European tradition.

Nestled amidst the serene mangroves of Jubail Island, ADREA spans 18,000 square metres within a lush 65,000-square-metre sanctuary offering exceptional equestrian and cultural experiences. Home to more than 40 of the world’s finest pure Spanish-bred white stallions, ADREA safeguards equestrian knowledge through the region’s first and one of the world’s largest equestrian libraries, housing thousands of rare texts and an archival collection of global significance. Visitors can explore the UAE’s first bespoke saddle-making atelier, where historic craftsmanship is revived through a blend of artistry and heritage, as well as the Furusiyya Gallery, which features 173 rare artefacts dating back more than 2,000 years and tracing the evolution of horsemanship across civilisations.

Now officially open, Abu Dhabi Royal Equestrian Arts invites visitors to immerse themselves in a world where heritage meets performance art through equestrian shows, educational programmes and exhibitions that celebrate the horse as a timeless symbol of grace, culture and pride. Guided by the principles of horse welfare and the enduring values of Furusiyya, the school’s inauguration extends the Arab world’s rich equestrian legacy and reflects the UAE’s deep rooted connection to its heritage while positioning Abu Dhabi as a global hub for culture, art and excellence.

Royal Gala of Abu Dhabi Royal Equestrian Arts
Royal Gala of Abu Dhabi Royal Equestrian Arts

 

Royal Gala of Abu Dhabi Royal Equestrian Arts
Royal Gala of Abu Dhabi Royal Equestrian Arts

 

 

 

Japan-Hong Kong Innovation and Technology Forum Ushers in a New Chapter for Bilateral Innovation and Technology Collaboration


HONG KONG SAR – Media OutReach Newswire – 31 October 2025 – The Hong Kong Science and Technology Parks Corporation (HKSTP) joins hands with the Consulate-General of Japan in Hong Kong, DEFTA Partners, and the Alliance Forum Foundation in Special Consultative Status with the United Nations ECOSOC to co-host today’s Japan-Hong Kong Innovation and Technology Forum. The event successfully concluded as it convened distinguished leaders from government, academia, and industry, reaffirming Hong Kong’s position as a world-class launchpad for innovation and a strategic bridge between Japan’s deep tech capabilities and Hong Kong’s globally connected innovation and technology (I&T) ecosystem.

HKSTP joins hands with the Consulate-General of Japan in Hong Kong, DEFTA Partners, and the Alliance Forum Foundation in Special Consultative Status with the United Nations ECOSOC to co-host today’s Japan-Hong Kong Innovation and Technology Forum. Amb Jun Miura, Consul-General of Japan in Hong Kong (Centre), Amb George Hara, Group Chairman & CEO, DEFTA Partners (2nd from left), Ms Lillian Cheong, Under Secretary for Innovation, Technology and Industry of the HKSAR (2nd from right), Prof Yutaka Matsuo, University of Tokyo (1st from left, and Mr Terry Wong, Chief Executive Officer of HKSTP (1st from right), officiates the event.
HKSTP joins hands with the Consulate-General of Japan in Hong Kong, DEFTA Partners, and the Alliance Forum Foundation in Special Consultative Status with the United Nations ECOSOC to co-host today’s Japan-Hong Kong Innovation and Technology Forum. Amb Jun Miura, Consul-General of Japan in Hong Kong (Centre), Amb George Hara, Group Chairman & CEO, DEFTA Partners (2nd from left), Ms Lillian Cheong, Under Secretary for Innovation, Technology and Industry of the HKSAR (2nd from right), Prof Yutaka Matsuo, University of Tokyo (1st from left, and Mr Terry Wong, Chief Executive Officer of HKSTP (1st from right), officiates the event.

Among the distinguished guests were Ambassador Jun Miura, Consul-General of Japan in Hong Kong; Ms Lillian Cheong, Under Secretary for Innovation, Technology and Industry of HKSAR; Ambassador George Hara, founder of DEFTA Partners and advisor to HKSTP; Mr Terry Wong, CEO of HKSTP; and global AI expert Professor Yutaka Matsuo of the University of Tokyo.

Amb Jun Miura, Consul-General of Japan in Hong Kong, said: “The increasing importance of Hong Kong and HK-Shenzhen-Guangzhou cluster as a hub for innovation and technology based on their capital, information, universities and talent is becoming clear, especially as the pace of technological advancement, including AI, and changes in the business environment, accelerates.” He added: “Now is the time for Japan and Hong Kong to explore opportunities of collaboration in innovation and technology, based on their longstanding relationship. “,” I hope that the startups of Hong Kong will visit various parts of Japan and deepen their understanding of the various opportunities that Japanese local cities provide. Likewise, I would like to see more Japanese startups come to Hong Kong to seize opportunities. By doing so, hopefully both Japan and Hong Kong can grow together in the field of innovation and technology.”

Ms Lillian Cheong, Under Secretary for Innovation, Technology and Industry of the HKSAR, said that the Government has spared no efforts in devising support measures to promote the development of start-up ecosystem in Hong Kong, citing the $10 billion Research, Academic and Industry Sectors One-plus Scheme, the launch of the $180 million Pilot I&T Accelerator Scheme as well as the setting up of a $10 billion Innovation and Technology Industry-Oriented Fund and the relaxation of application threshold for the New Industrialisation Acceleration Scheme. She expressed confidence that Japanese I&T enterprises can benefit greatly from setting up footholds in Hong Kong with a view to tapping the vast Mainland and overseas markets.

Mr Terry Wong, CEO of HKSTP, said, “Our forum today exemplifies this spirit, bringing together Japan’s deep tech strength and Hong Kong’s global platform to unlock a new era of collaboration. At HKSTP, we are committed to enabling startups to go global while attracting international innovation leaders to land and scale in Hong Kong. To date, more than 150 tech enterprises have participated in nine major innovation events across Japan, generating over USD 5 million in commercialisation value through increased exposure and strategic partnerships.”

He added that HKSTP is fast-tracking the development of INNOPOLE, a new 20-hectare San Tin Technopole campus within the Northern Metropolis. This strategic initiative is designed to create a powerful economic engine, providing expansive space for AI development and Greater Bay Area collaboration. INNOPOLE will solidify Hong Kong’s position as the world’s premier gateway for innovation.

Amb George Hara, Group Chairman & CEO, DEFTA Partners, shared insights at the keynote speech, and said: “The momentum from today’s forum is a clear signal that the future of tech will be written through collaboration. We are committed to bring strategic alliance with Japanese corporates, leveraging DEFTA’s expertise to turn the promising sciences and technologies out of Hong Kong into the groundbreaking enterprises of tomorrow.”

As Chairman of the Alliance Forum Foundation, he said “Hong Kong serves as a pivotal junction between Japan, China and the United States, holding significant geopolitical importance. Should Japan’s industrial sector contribute to growth by commercialising new technologies emerging in Hong Kong universities and establishing technology industries, while introducing the concept of public-benefit capitalism to cultivate a prosperous middle class, Hong Kong could become a model city for the 21st century and set an example for many Asian cities. Fostering a prosperous middle class also contributes significantly to building democracy and peace. Everything hinges on what kind of city Hong Kong’s business leaders envision for its future”.

At the forum, panel discussions explored topics including artificial intelligence, investment, business collaboration, and bio-related technologies. These sessions brought together entrepreneurs, scientists, and industry leaders from Japan and Hong Kong to share insights and explore opportunities for mutual growth.

The Japan-Hong Kong Innovation and Technology Forum laid a strong foundation for future bilateral engagement, fostering ongoing collaboration and shared success. HKSTP continues to drive global expansion for Hong Kong startups through its “Attract In and Expand Out” strategy, and remains committed to deepening its alliance with Japanese stakeholders, leveraging collective strengths to drive innovation and co-create a dynamic I&T ecosystem that addresses global challenges and supports sustainable growth.
Hashtag: #HKSTP #HongKongScienceandTechnologyParksCorporation

The issuer is solely responsible for the content of this announcement.

NAVEE Launches XT5 Pro All-Terrain Electric Scooter, Expanding Green Mobility Beyond the City

EL MONTE, Calif., Oct. 31, 2025 /PRNewswire/ — NAVEE, a leading innovator in smart mobility, today unveils the XT5 Pro All-Terrain Electric Scooter, designed for riders seeking both performance and sustainability. The XT5 Pro will be available through NAVEE’s official online store and Amazon, priced at $1,499.99.

Built for exploration, the XT5 Pro features a 2,200 W high-torque rear motor, delivering 30% more climbing power and a top speed of 31 mph (50 km/h). Its automotive-grade regenerative braking system recovers energy during rides, extending the range up to 46 miles (75 km). Supporting a maximum load capacity of 331 lbs (150 kg), it comes with Front & Rear Dual-side Arm Damping Spring Suspension, 12-inch all-terrain tubeless tires, and 163 mm of ground clearance for stability on gravel, mud, and steep terrain.

XT5 Pro All-Terrain Electric Scooter
XT5 Pro All-Terrain Electric Scooter

The XT5 Pro has earned UL certification for off-road performance in range, energy efficiency, and acceleration, validating its excellence in core metrics. It also received TÜV Rheinland’s “Full-Speed True Range” certification, verifying consistent range performance even at top speeds.

The XT5 Pro comes equipped with NAVEE’s Traction Control System (TCS), a triple braking setup — front drum, rear disc, and E-ABS — and smart connectivity through the NAVEE App, where riders can track routes, customize performance, and check battery status. Additional features include Apple Find My integration for theft prevention and an adaptive 9W headlight for safer night rides.

Known for its bold industrial-inspired design, the XT5 Pro’s sharp lines and modular frame draw inspiration from off-road vehicles like the Can-Am Maverick X3 and Tesla Cybertruck. Reflecting this design excellence, the model was recently recognized in Fortune China’s “Top 50 Chinese Enterprise Design Awards” for its balance of innovation, aesthetics, and sustainability.

Unlike traditional fuel-powered off-road vehicles, the XT5 Pro delivers powerful performance with zero emissions and minimal noise — a testament to NAVEE’s commitment to sustainable innovation.

“Outdoor mobility is evolving fast,” said Zhuang, Product Director at NAVEE. “The XT5 Pro is built for people who are seeking longer journeys—from city streets to mountain paths, while staying true to sustainable living.”

About NAVEE

NAVEE is a leading brand in electric mobility, recognized for its industry-leading suspension technology, and as the fastest-growing new brand in sales, delivering products with cutting-edge design and sustainability. Discover how NAVEE is shaping the next generation of smart urban mobility at https://naveetech.us/.

 

Zhimeng Biopharma’s investigational drug CB03-154 for amyotrophic lateral sclerosis has achieved the first patient first dose milestone in the phase 2/3 pivotal clinical trial.

SHANGHAI, Oct. 31, 2025 /PRNewswire/ — Shanghai Zhimeng Biopharma Inc. ( “Zhimeng”) announced that its self-developed new-generation potassium channel opener CB03-154 for the treatment of amyotrophic lateral sclerosis (ALS) has officially initiated the phase 2/3 clinical trial and completed the first patient first dose at the 2nd Affiliated Hospital of Hebei Medical University. Previously (in July 2025), CB03-154 received approval from the China Center for Drug Evaluation (CDE) to conduct the ALS phase 2/3 adaptive clinical trial. The CB03-154 has also been granted orphan drug status in the United States in October 2023 for the treatment of ALS.

This phase 2/3 clinical trial is a multicenter, randomized, double-blind, placebo-controlled study with open-label extension. This study is led by Professor Fan Dongsheng from the 3rd Affiliated Hospital of Peking University as the leading investigator nationwide. This study will enroll approximately 240 patients diagnosed with ALS in about 15 centers in China. The disease duration of to be enrolled patients will be within 24 months from the first symptom onset to the screening visit. The primary efficacy endpoint of the study is the change from baseline at week 39 of the revised ALS Functional Rating Scale (ALSFRS-R) score.

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal central nervous system disease with unknown etiology. It mainly affects the motor neurons in the cerebral cortex, brainstem, and spinal cord. The pathological features of ALS include the loss of upper and lower motor neuron cell bodies, as well as the degeneration of the corticospinal tract/corticobulbar tract and axons of lower motor neurons, and the occurrence of denervation changes in muscles. Clinically, it mainly presents as progressive skeletal muscle weakness, atrophy, fasciculation, bulbar palsy, and pyramidal tract signs. The median survival duration is generally 2 to 3 years after the onset of symptoms. The main cause of death is neuromuscular respiratory failure. The annual incidence of ALS in Europe and the United States is 2/100,000 to 3/100,000, and the prevalence rate is 3-5/100,000. The peak age of onset is 50 to 75 years. Approximately 10% of ALS patients are familial, while the remaining 90% are sporadic. Currently, there are no treatments that can stop or reverse the progression of the disease. Therefore, clinical management focuses on early diagnosis and early treatment to maximize the survival time. Currently, only three drugs have been approved worldwide for ALS, namely Riluzole, Edaravone, and Tofersen (trade name Qalsody). These approved drugs can only slightly improve the patient’s function or slightly prolong the survival time. Therefore, ALS still has a huge unmet medical need.

Although the pathogenesis of ALS has not been fully deciphered, studies have found that it is closely related to changes in ion channels, synaptic transmission and connections, as well as the imbalance of excitation and inhibition of neurons. Among them, the potassium ion (K+) channel is the most widely distributed and has the largest variety, mainly participating in regulating the excitability of neurons and the frequency and amplitude of action potential generation. Currently, there are no marketed KCNQ2/3 potassium ion channel openers available for ALS patients. The only KCNQ2/3 potassium ion channel opener that was approved by the FDA and EMA, ritigabine (Potiga, Ezogabine/Retigabine), was once studied in ALS patients and showed a favorable signal. However, due to the risks of pigmentation-induced vision impairment and other risk factors, it was withdrawn from the market in 2017.

CB03-154 is a new generation selective voltage-gated potassium channel (KCNQ2/3) opener, independently developed by Zhimeng. Compared with the first-generation potassium channel opener ritigabine, CB03-154 has superior selectivity and stability. In vitro studies have confirmed that CB03-154 can significantly reduce the excessive excitation of iPSC motor neurons from ALS patients. Moreover, in the SOD-1 ALS transgenic mouse model, daily oral administration of CB03-154 (10 mg/kg) can effectively prolong the survival time, delay the onset, improve motor ability, alleviate neuronal damage, and slow down the rate of muscle atrophy.

The initiation of this Phase 2/3 clinical trial is a significant step for CB03-154 in the field of rare diseases, and it brought hopes to provide an important new treatment option for ALS patients.

About Zhimeng 

Founded in 2018, Shanghai Zhimeng Biopharma, Inc. is a biopharmaceutical company dedicated to develop small-molecule drug discovery with focused on the functional cure of chronic hepatitis B (CHB), as well as novel therapies for CNS disorders, including epilepsy, neuropathic pain (e.g. cancer-related pain), amyotrophic lateral sclerosis (ALS), major depressive disorder (MDD), and bipolar disorder.

Disclaimer

This press release contains forward-looking statements. While Zhimeng considers the projections to be based on reasonable assumptions, these forward-looking statements may be called into question by a number of hazards and uncertainties, so that actual results may differ materially from those anticipated in such forward-looking statements.

For more information, please visit: www.corebiopharma.com 

NYSE Content Advisory: Pre-Market Update + Emera Celebrates NYSE Listing

NEW YORK, Oct. 31, 2025 /PRNewswire/ — The New York Stock Exchange (NYSE) provides a daily pre-market update directly from the NYSE Trading Floor. Access today’s NYSE Pre-market update for market insights before trading begins.

 

NYSE Content Advisory: Pre-Market Update + Emera Celebrates NYSE Listing

Ashley Mastronardi delivers the pre-market update on October 31st

  • Stocks are mixed Friday morning following fresh earnings from some of the magnificent seven. Amazon and Apple are both on pace to open in the green after favorable earnings from the two tech giants.
  • Investors are also monitoring the latest developments on trade after President Trump and Chinese leaders agreed to a one-year trade truce following a meeting in South Korea this week.
  • Wall Street is also looking toward the next Fed meeting in December after Chair Powell said on Wednesday that an additional rate cut this year was not a foregone conclusion.

Opening Bell
Emera (NYSE: EMA) celebrates its recent listing on the New York Stock Exchange

Closing Bell
Wipro (NYSE: WIT) celebrates its 25th anniversary of listing

Click here to download the NYSE TV App

 

BingX Bridges TradFi and Web3 at Blockchain Life 2025, Celebrates Top Industry Recognition

PANAMA CITY, Oct. 31, 2025 /PRNewswire/ — BingX, a leading cryptocurrency exchange and Web3 AI company, marked a strong presence as a Strategic Sponsor at Blockchain Life 2025, the 15th International Forum on Web3, Cryptocurrencies, and Mining. Held on October 28–29 in Dubai, U.A.E., the event gathered attendees from 130 countries, spotlighting the next phase of digital finance and blockchain innovation.

BingX Bridges TradFi and Web3 at Blockchain Life 2025, Celebrates Top Industry Recognition
BingX Bridges TradFi and Web3 at Blockchain Life 2025, Celebrates Top Industry Recognition

BingX engaged participants through an interactive booth experience featuring community activities and merchandise giveaways, emphasizing its commitment to accessibility, education, and engagement within the blockchain ecosystem.

At the event, Vivien Lin, Chief Product Officer at BingX, was honored with the Blockchain Life Award 2025 for Top Woman in Crypto of the Year. The recognition underscores her leadership in driving BingX’s AI-powered product strategy and promoting inclusivity and innovation in Web3.

Receiving the award, Lin commented: “Being recognized as Top Woman in Crypto of the Year is an honor, and it highlights the growing presence and influence of women shaping the Web3 industry. It reflects how diverse leadership and perspectives are essential to driving balanced, thoughtful innovation in the digital asset space.”

Lucas L., Head of Fiat Business at BingX, participated in a Day 1 roundtable titled “Stablecoins and Banks: Connecting Crypto and Traditional Finance”. He examined how fiat and blockchain systems are converging to create a more efficient and accessible global financial infrastructure. Lucas underscored the critical role of exchanges in building robust systems for users across the community in risk management, user protection, and transparency within the stablecoin ecosystem, noting that BingX aims to make the bridge between traditional finance and blockchain safe, scalable, and sustainable.

About BingX 

Founded in 2018, BingX is a leading crypto exchange and Web3 AI company, serving a global community of over 20 million users. With a comprehensive suite of AI-powered products and services, including derivatives, spot trading, and copy trading, BingX caters to the evolving needs of users across all experience levels, from beginners to professionals. Committed to building a trustworthy and intelligent trading platform, BingX empowers users with innovative tools designed to enhance performance and confidence. In 2024, BingX proudly became the official crypto exchange partner of Chelsea Football Club, marking an exciting debut in the world of sports sponsorship.

For more information, please visit: https://bingx.com/