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Rocket Travel by Agoda Launches the Loyalty Value Playbook to Help Travel Leaders Stay Ahead of the Loyalty Game

The new report by Rocket Travel by Agoda and Skift reveals framework for brands to close the loyalty value gap with seamless redemptions and cash spend

SINGAPORE, Nov. 6, 2025 /PRNewswire/ — As customer expectations rapidly evolve, their perception of traditional loyalty models evolves with it. As a result, many loyalty programs face a widening “value gap” between what members want and what brands deliver, according to a new report co-developed by Skift and Rocket Travel by Agoda – the strategic partnerships arm of digital travel platform Agoda.

Titled ‘The Loyalty Value Playbook: Redemption Experience and Cash Spend as the New Benchmarks for Customer Growth’, the report offers a practical blueprint to close the loyalty gap. With 77% of consumers now quicker to drop a program than they were three years ago, this underscores how consumers are increasingly prioritizing loyalty on platforms that deliver value through clarity, flexibility, and relevance throughout the customer journey.

Rocket Travel by Agoda has launched a guide to help companies transform failing loyalty programs based on clear metrics. The guide includes six capabilities that focus on getting the most out of loyalty programs by focusing on best practice in redemption, usability, transparency, and exclusivity:

  1. Flexible Commerce Infrastructure: Streamline checkouts with real-time point balances, instant confirmations, and points-plus-cash options to match modern e-commerce standards.
  2. Data and Personalization Engine: Harness guest behavior and AI-driven insights to deliver tailored recommendations, increasing redemption value and booking conversions.
  3. Partner and Inventory Strategy: Expand high-quality room and experience inventory with competitive pricing and exclusive perks like early check-in or late checkout.
  4. Marketing Technology and Customer Journeys: Minimize point breakage with lifecycle messaging and clear value explanations to spur repeat cash bookings.
  5. Governance and Controls: Enforce fair dynamic pricing with transparent rules and advance notices to sustain guest trust and reduce complaints.
  6. Cross-Functional Ways of Working: Unite loyalty, operations, and data teams to optimize metrics like repeat cash bookings and guest lifetime value.

Rocket Travel By Agoda developed the guide to help companies understand why traditional loyalty programs may need to evolve to meet modern guest expectations, risking lost revenue for brands. For instance, according to Antavo’s Global Customer Loyalty Report, only around 50% of loyalty points earned are redeemed, while in a report by Cordial, 43% of customers stopped participating because the rewards took too long to earn.

Grounded in original research, case studies, and expert interviews, the playbook shows how well-crafted loyalty programs drive repeat bookings and cash spend, strengthening guest relationships. By leveraging zero-friction experiences and AI-driven personalization, it empowers travel brands spanning airlines, hotels, and beyond to meet the demands of modern travelers, in line with Agoda’s commitment to making travel more accessible and rewarding.   

“The challenge and opportunity for loyalty programs is that expectations haven’t shifted from one set of benefits to another, they have expanded. Travelers still want the traditional perks, but they also expect more, making loyalty harder to manage,” says Damien Pfirsch, Chief Commercial Officer and Head of Rocket Travel at Agoda. “This report equips travel brands with a playbook to rebuild guest trust through clear, flexible, and relevant loyalty experiences, boosting both point redemptions and cash bookings.”

Rocket Travel by Agoda leverages its extensive industry expertise to guide partners in crafting loyalty programs that resonate with their audiences, build loyalty, and support sustainable growth. With a clear focus on personalized and flexible offerings, brands can build lasting customer relationships and elevate their market presence. Download the full report here.

 

ICP DAS Brings Energy Management and Safety Monitoring to the Forefront at IIFES 2025

HSINCHU, Nov. 6, 2025 /PRNewswire/ — ICP DAS is pleased to announce its participation in IIFES 2025 – Innovative Industry Fair for E x E Solutions, taking place from November 19–21, 2025, at Tokyo Big Sight, Japan. Visitors are welcome to meet the ICP DAS team at Booth No. 5-19-1.

Image by ICP DAS
Image by ICP DAS

At this year’s exhibition, ICP DAS will showcase its latest solutions in energy management, environmental monitoring, and industrial connectivity, designed to accelerate the transition toward smarter, safer, and more efficient factories.

A central highlight will be a live demo system integrating Energy Management Solutions, Air Quality Monitoring, and Liquid Leak Detection. The system demonstrates how enterprises can achieve real-time visibility of energy consumption, workplace safety, and environmental conditions through IoT-based monitoring and control.

For energy management, ICP DAS will feature its PMC series power management controllers, PM series smart power meters, and IoTstar cloud management software, providing enterprises with powerful tools to monitor usage and optimize efficiency.

To ensure healthier and safer work environments, ICP DAS will present its DL series data loggers, including the compact DL-10, versatile DL-300, and high-capacity DL-1000, which monitor temperature, humidity, CO₂, and other air quality parameters. The Liquid Leak Detection Module will also be introduced as a reliable safeguard against equipment or infrastructure damage caused by water leakage.

ICP DAS will further highlight its IR Temperature Sensor through a dedicated demo setup, demonstrating accurate non-contact temperature measurement for industrial environments. In addition, the company will present a range of industrial communication devices such as the tGW series Modbus gateways, tSH series serial converters, and remote I/O modules, all developed to simplify system integration and enhance data connectivity across diverse applications.

Through these offerings, ICP DAS demonstrates its commitment to advancing smart automation solutions that combine efficiency, safety, and connectivity to meet the evolving needs of modern industry.

About ICP DAS

Founded in 1993 and headquartered in Taiwan, ICP DAS is a global leader in industrial automation and IoT solutions. With more than three decades of expertise, the company delivers hardware and software that empower businesses to embrace Industry 4.0 and the Industrial Internet of Things (IIoT). By combining strong R&D capabilities with international market experience, ICP DAS continues to drive innovation that transforms factories, utilities, and infrastructure worldwide.

For more information, visit: https://www.icpdas.com

Veteran Compliance Leader from HSBC, PayPal, ByteDance and Aspire, Appointed as Group Chief Compliance Officer at Alpha Ladder Group to Drive Trusted Digital Finance

SINGAPORE, Nov. 6, 2025 /PRNewswire/ — Alpha Ladder Group Pte. Ltd. (ALG), Singapore’s digital green group and parent company of MetaComp Pte Ltd (MPI license with Digital Payment Token) and Alpha Ladder Finance (CMS and RMO licenses), welcomes Summer Yu, who has recently joined the Group as Group Chief Compliance Officer. Reporting directly to Dr Bo Bai, Executive Chairman and Co-Founder, she oversees the Group’s compliance strategy, governance frameworks, and regulatory engagements across its subsidiaries. Yu brings over two decades of experience in global compliance, licensing, and financial crime risk management, having led compliance frameworks at some of the world’s leading financial institutions and high-growth fintechs.

Summer Yu, Group Chief Compliance Officer, Alpha Ladder Group
Summer Yu, Group Chief Compliance Officer, Alpha Ladder Group

Yu is a globally experienced compliance leader with a proven track record in building and scaling regulatory frameworks across banking, payments, and digital-asset sectors. Over her career, she has held senior roles at leading global financial institutions and fintechs, where she led multi-jurisdictional engagements with regulators and established enterprise-wide governance, financial crime, and operational resilience programs. Her expertise spans the full spectrum of compliance and risk domains, from AML/CFT and safeguarding to tokenisation and digital-asset governance, across major markets in Asia, Europe, and North America.

Dr Bo Bai, Executive Chairman and Co-Founder of Alpha Ladder Group, said, “Summer’s appointment underscores our commitment to the highest standards of compliance as we continue to scale our platforms across payments, FX, and digital assets. Her track record in building world-class compliance frameworks at global institutions and fintechs will be invaluable in ensuring Alpha Ladder Group continues to innovate responsibly while maintaining the trust of regulators and partners worldwide.”

Summer Yu, Group Chief Compliance Officer of Alpha Ladder Group, said, “I’m deeply honoured to join Alpha Ladder Group at this exciting stage of its journey. Compliance is not only about meeting regulatory requirements, it is about building the foundation for sustainable and inclusive financial innovation. I look forward to working with the team to strengthen our governance and ensure our products and services remain safe, scalable, and trusted.”

For more information regarding Alpha Ladder Group and its subsidiaries, please visit www.alphaladder.com.

About Alpha Ladder Group

Alpha Ladder Group is a leading Digital Green Group shaping the future of financial innovation, financial technology, and sustainable technology. With a growing portfolio of subsidiaries, we deliver capabilities across climate SaaS, stablecoin-enabled payment and wealth services, and green impact investments.

Driven by cutting-edge technologies such as blockchain and AI, we empower sustainable investments, build digital financial infrastructure, and pioneer wealth innovation. Through our vision of Digital Green Transformation with Technologies, we’re building a smarter, more resilient, and responsible financial ecosystem—one that mirrors the universe’s own journey from elemental simplicity to structured brilliance.

At Alpha Ladder, our name isn’t just symbolism—it’s how we move the world forward to pursue infinite alpha, one particle at a time.

To learn more about us, please visit www.alphaladder.com.

Shipsy Recognized in the 2025 Gartner® Asia/Pacific Context: ‘Magic Quadrant™ for Warehouse Management Systems

SINGAPORE, Nov. 6, 2025 /PRNewswire/ — Shipsy, a leading provider of AI-native solutions for the supply chain and logistics technology industry, today announced that it was recognized as a Notable Vendor in the 2025 Gartner Magic Quadrant for Warehouse Management Systems in the Asia-Pacific Context.

Gartner’s 2025 Asia/Pacific Context recognizes vendors that demonstrate market relevance, customer impact, and strong regional growth in the Warehouse Management Systems segment. Shipsy’s alignment with these parameters further cements its position as a trusted technology partner for enterprises evolving their supply chain ecosystems.

As supply chains in the Asia-Pacific region grapple with demand volatility, inventory optimization pressures, and the need for real-time visibility across operations, companies are seeking advanced warehouse management solutions that can seamlessly integrate with broader logistics operations encompassing procurement, transportation, order fulfillment, and delivery execution.

Shipsy’s AI-Native Warehouse Management System addresses these challenges by combining intelligent automation, predictive analytics, and real-time operational visibility into a unified platform. With strong customer adoption across India, the Middle East, Europe and Southeast Asia, Shipsy is empowering businesses to drive visibility, efficiency, and cost-to-serve across B2B and B2C logistics networks.

“As businesses embrace AI-native warehouse operations, our focus is on delivering autonomous decision-making capabilities from intelligent slotting and predictive inventory placement to AI-powered labor optimization and real-time exception management enabling warehouses to function as strategic assets that adapt in real-time to demand volatility and support sustainability goals through optimized resource utilization.” said Soham Chokshi, Co-Founder & CEO, Shipsy.

Shipsy’s unified supply chain platform approach integrates warehouse management with transportation management, enabling companies to break down operational silos and unlock optimization opportunities across their entire distribution network. This comprehensive approach has enabled leading enterprises across 30+ countries to transform their supply chain operations.

Shipsy’s Warehouse Management System is built on an AI-native architecture that enables:

  • Intelligent Automation: AI-powered workflows that optimize receiving, putaway, picking, packing, and shipping operations
  • Real-Time Visibility: Complete transparency across warehouse operations with predictive insights for proactive decision-making
  • Seamless Integration: Native connectivity with Shipsy’s Transportation Management System for end-to-end supply chain visibility
  • Scalable Architecture: Cloud-based infrastructure designed to support operations across multiple warehouses and geographies
  • Multi-Modal Support: Comprehensive capabilities for diverse warehouse environments

Shipsy’s WMS supports a wide range of warehouse operations, from e-commerce fulfillment centers to large-scale distribution operations for enterprise manufacturers and 3PL providers. The platform’s AI capabilities continuously learn from operational data to provide intelligent recommendations for inventory positioning, labor optimization, and order fulfillment strategies.

To learn more about Shipsy’s Warehouse Management System and AI-powered supply chain solutions, please visit www.shipsy.ai.

Gartner Disclaimer

Gartner does not endorse any vendor, product or service depicted in its research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner’s research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.

GARTNER is a registered trademark and service mark of Gartner Inc. and/or its affiliates in the U.S. and internationally, Magic Quadrant is a registered trademark of Gartner, Inc. and/or its affiliates and is used herein with permission. All rights reserved.

About Shipsy:

Shipsy’s AI-native Enterprise Transportation Management Platform is helping Fortune 1000 companies transition to autonomous supply chains. With Agentic AI at its core, Shipsy drives enterprise-wide transformation for 150+ customers in 30+ countries. Shipsy operates from global offices across London, Amsterdam, Riyadh, Dubai, Singapore, and Sydney, with innovation hubs in India. Visit www.shipsy.ai.

DeepL Unveils Next-Gen Language AI tools and Game-Changing Agentic Productivity Solution

  • DeepL Agent now available – transforming knowledge worker productivity and automating the modern workplace
  • DeepL Customization hub centralizes all language requirements to reduce cost and friction in business translation workflows
  • Over 100 languages will now be available on DeepL

BERLIN, Nov. 6, 2025 /PRNewswire/ — DeepL, a leading global AI product and research company, today announced two major business innovations for knowledge workers – DeepL Agent and Customization Hub. 

During its annual conference, DeepL Dialogues, the company unveiled the general availability of DeepL Agent, an autonomous AI coworker designed to streamline and automate a broad-range of tasks for knowledge workers. DeepL also announced continued innovations in Language AI with the release of Customization Hub and the announcement of over 70 new languages to the platform.

Jarek Kutylowski, CEO and Founder of DeepL said: “As DeepL advances its broader mission, our vision is clear: to unlock human potential by transforming work across languages and beyond. Translation remains at our core, and with today’s announcements, we are proud to expand this foundation while pioneering agentic AI innovations.”

“Our customers face a common challenge: repetitive, inconsistent tasks that drain productivity. DeepL Agent and Customization Hub tackle this together: our agentic solution liberates teams to focus on high-impact work by automating routine processes, while Customization Hub accelerates project completion by minimizing manual reviews. Together, they redefine efficiency, speed, and scale, empowering businesses to thrive amid the evolving demands of language and work.”

“By combining intelligent tools with human expertise in the loop, we’re not just enhancing individual productivity; we’re empowering entire organizations to achieve their most important goals.”

Introducing DeepL Agent

With the average knowledge worker toggling between different apps and websites nearly 1,200 times a day and losing 11 hours every week chasing data across systems, the need for better productivity tools has never been higher. Tools that centralize everything in one place, reducing context switching, are the future of business solutions. After extensive beta testing, with over 1,000 internal and external users, as well as completing over 20,000 tasks, DeepL Agent is now generally available.

DeepL Agent is an AI coworker designed to enhance productivity by reasoning, planning, and acting on users’ behalf, while incorporating human-in-the-loop oversight to ensure precision, control, and seamless collaboration. For example, it can serve as a sales agent that autonomously researches prospects in a CRM, drafts personalized outreach messages, and schedules follow-ups. In customer service, it can resolve issues, process exchanges, and check inventory without requiring human intervention. Additionally, as a marketing agent, it can identify trends, analyze competitors, generate content, and coordinate campaigns from start to finish. By streamlining these everyday tasks, DeepL Agent allows teams to focus more on strategic initiatives.

DeepL Agent works seamlessly with existing systems such as CRM, email, calendars, knowledge hubs, and project management tools, allowing it to understand and adapt to a company’s unique data, workflows, and business logic. Operating with enterprise-grade security and control, DeepL Agent can be used by everyone and doesn’t require complex integrations to deliver value, all while prioritizing data sovereignty and privacy.

Enabling brand language harmony globally

DeepL Dialogues also saw the introduction of Customization Hub, a powerful platform that combines glossaries, style rules and translation memories into one system. The Customization Hub builds on DeepL’s context-aware language quality by automatically enforcing language requirements during the translation process and minimizing errors at scale. This allows teams to spend less time on post-editing.

It helps companies keep their unique brand voice and terminology consistent while speeding up translations and improving quality. By streamlining workflows and addressing challenges of inconsistent messaging, this solution aims to improve efficiency and quality of translations. This supports businesses in achieving reliable translations at scale while managing costs and minimizing review cycles.

The current localization process is slow, fragmented, and prone to errors. Language requirements are scattered across different tools, making them difficult to track and use effectively. As a result, teams spend significant time fixing issues after translation instead of focusing on creativity and nuance across languages. By providing DeepL with the context of a language expert, companies ensure accurate translations, faster reviews, fewer errors, and significant cost savings at scale.

DeepL to add around 70 new languages

DeepL also announced a major expansion of its language offerings by growing to over 100 languages, adding around 70 in beta for enterprise customers, bringing nearly all the top twenty most spoken global languages to the platform. In the EMEA region, all 24 official EU languages will now be available, along with Croatian, Bosnian, Serbian, Swahili, Afrikaans, and Malagasy. In the Asia-Pacific region, new languages will include Hindi, Malay, Tagalog, Bengali, Marathi, Tamil, and Urdu, all in response to enterprise customer requests.

DeepL Dialogues marks the culmination of a bumper 2025 for DeepL, which saw the roll out of several new products, including DeepL Voice for Zoom, DeepL Marketplace and now DeepL Agent. DeepL continues to deliver AI solutions that drive enterprise efficiency—from language translation to everyday workflows. Innovation and R&D remain at the core of DeepL’s strategy, powering smarter, deeply integrated AI that transforms how businesses operate globally.

About DeepL: DeepL is a global AI product and research company focused on building secure, intelligent solutions to complex business problems. Over 200,000 customers and millions of individuals across 228 global markets today trust DeepL’s Language AI platform for human-like translation, improved writing and real-time voice translation. Building on a history of innovation, quality and security, DeepL continues to expand its offerings beyond the field of Language, including with DeepL Agent – an autonomous AI assistant designed to transform the way businesses and knowledge workers get work done. Founded in 2017 by CEO Jaroslaw “Jarek” Kutylowski, DeepL now has over 1,000 passionate employees and is supported by world-renowned investors including Benchmark, IVP, and Index Ventures. For more information on DeepL, visit www.deepl.com.

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Arta announces expansion of Arta AI, aiming to empower every financial advisor and wealth manager with an AI Sidekick; onboards new institutional customers

Bank of Singapore and Hong Leong Bank are adopting Arta AI, joining a growing network of banks and wealth platforms leveraging Arta’s platform to transform their wealth offerings

SINGAPORE, Nov. 6, 2025 /PRNewswire/ — Arta today announced the expansion of Arta AI, a SaaS platform purpose-built to empower individuals and financial institutions with AI agents for wealth management. Now available to all investors, wealth managers and advisors globally at arta.ai, the AI Sidekick is now being deployed across a growing network of banks and wealth management firms – with Bank of Singapore, Hong Leong Bank, and Ethivo Asset Management (HK) Ltd, formerly known as UCAP HK AM Ltd joining existing clients Wio Invest operated by Wio Securities LLC and Income Advisory Financial Advisers, a wholly-owned subsidiary of Income Insurance Limited — reflecting strong demand from both traditional and next-generation financial institutions.

Arta AI Sidekick gives every advisor a dedicated AI agent that connects client portfolios, firm data, research, and product intelligence to surface relevant portfolio information and streamline day-to-day workflows. It helps advisors make faster, more informed decisions and engage each client at scale, and frees up their time to spend on direct relationships and higher-value advisory services. 

“Financial institutions of every stage, from established private banks to digital-native wealth or investing platforms, are realizing that AI can drive scale, engagement and rigor while maintaining the human connection that defines great client service,” said Caesar Sengupta, CEO of Arta. “Arta AI is purpose-built for wealth and investing. It augments advisor expertise, strengthens analytical rigor, and ensures transparency across all client interactions.”

AI That Works With A Private Banker

Arta AI delivers institutional-grade analytics through an intuitive conversational interface. It combines generative AI with vetted data, real-time market pricing, and firm-specific CIO research to give advisors and clients the tools to automate analytical and reporting tasks and explore new ways to enhance client engagement. Advisors can instantly analyze portfolios, run Monte Carlo simulations or stress tests, integrate proprietary research, and communicate in multiple languages. 

Arta AI integrates seamlessly into banks’ and brokerages’ ecosystems, enabling white-label deployment and firm-specific training for brand voice, compliance, and proprietary research. Advisors can aggregate holdings across asset classes, automate reports, and refine their proactive outreach — turning every client touchpoint into an opportunity to grow and deepen the relationship.

Arta AI in Action with Leading Private Banking Institutions

Among its clients, Bank of Singapore — a wholly owned private banking subsidiary of OCBC, Southeast Asia’s second-largest financial services group — is deploying Arta AI to enhance its offering for external asset managers (EAMs) and family offices.

Leong Guan (LG) Lim, who is the Bank of Singapore Global Head of Financial Intermediaries, Family Office, and Wealth Advisory (FFWA), oversees one of the bank’s fastest-growing segments. The FFWA desk supports EAMs and family offices with institutional-grade investment products and technology solutions.

LG Lim explained that while Singapore has long been a hub for ultra-high-net-worth families, many EAMs and family offices still face challenges in leveraging technology that keeps pace with global markets. By deploying Arta AI, Bank of Singapore is helping EAM clients personalize portfolio management, automate deep investment research, and efficiently deliver proposals and market intelligence.

He said, “At Bank of Singapore, we see financial intermediaries as key partners in the evolution of private wealth management. Recognising their need for timely, diverse market insights, we want to support them in building their own investment views, supported efficiently and at-scale through technology. Arta stands out because it is purpose-built for wealth and investing, not repurposed from generic AI. We believe Arta AI will enhance our financial intermediary clients’ research capabilities, automate the quantitative heavy lifting for each portfolio, and enable them to focus on the bespoke, human-centric advice their clients value.”

For Hong Leong Bank (HLB), the collaboration with Arta AI is a key component of the bank’s strategic vision for growing its wealth business through forming value-adding alliances. HLB will leverage Arta AI to empower its relationship managers, enabling them to deliver tailored investment opportunities aligned with HLB’s product risk framework and benchmarked against the bank’s CIO research and model portfolios.

“At HLB, our priority is to empower our Relationship Managers with the right insights to better serve our clients,” said Jeffrey Yap, Managing Director and Regional Head of Wealth Management. “By connecting portfolio data, CIO research, and product-level risk models, we aim to make every recommendation more consistent, personalized, and aligned with our clients’ individual risk appetites. This initiative is an extension of HLB’s strong commitment to integrating AI across the organization, being one of the earliest banks in Malaysia to empower all employees with AI tools, and it directly supports our efforts to leverage technology and data for a more seamless, advisory-led wealth experience.”

About Arta

Arta is an AI-driven wealth and financial technology company headquartered in the United States and Singapore. The company is redefining how institutions deliver wealth management by providing AI driven agents and user interfaces that modernize investing experiences and deepen client relationships.

Through its regulated Arta Wealth business and enterprise SaaS platform, Arta AI, the company combines advanced artificial intelligence with human financial expertise and world-class experience design to enable smarter investment decisions, scalable personalization, and measurable business outcomes.

Arta’s enterprise wealth infrastructure allows banks, private banks, and financial institutions to launch modern investing platforms in a matter of months. Its Wealth-as-a-Service platform, built on a multi-custodian architecture, offers seamless API and white-label integration options. Designed with explainability, security, and compliance at its core, Arta’s AI infrastructure enhances advisor insights, product expertise, and relationship management — bringing the service quality of private banking to digital scale.

The company is backed by leading global investors, including Peak XV, Ribbit Capital, Coatue, and EDBI, as well as more than 140 prominent leaders in technology and finance such as Ralph Hamers (former CEO of UBS & ING), Piyush Gupta (former CEO of DBS), Eric Schmidt (former CEO of Google), Michael Miebach (CEO of Mastercard), and Lip Bu Tan (CEO of Intel).

For more information, visit arta.ai.

The World’s First Gene-Editing Therapy Targeting APOC3 for Hyperlipidemia

CorrectSequence Therapeutics’ CS-121 Completed Dosing of First Chylomicronemia Patient, Demonstrating Excellent Safety and Significant Efficacy

SHANGHAI, Nov. 6, 2025 /PRNewswire/ — On November 6, 2025, Shanghai, China, CorrectSequence Therapeutics Co., Ltd. (Correctseq), a clinical-stage biotechnology company pioneering transformer Base Editing (tBE) technology for the treatment of severe diseases, announced that the first patient in its Investigator-Initiated Trial (IIT) of the base-editing therapy CS-121 targeting APOC3 for chylomicronemia / hypertriglyceridemia has successfully completed dosing and been discharged from the hospital. 

The patient, diagnosed with chylomicronemia, had a long history of fasting triglyceride (TG) levels exceeding 12.5 mmol/L and recurrent acute pancreatitis. In the dose-escalation IIT for CS-121, his fasting TG level dropped significantly within three days after a single low-dose administration, with no adverse events.

This is the world’s first successful clinical treatment of hyperlipidemia with the gene-editing therapy targeting APOC3.

Picture: The world’s first patient of the gene-editing therapy targeting APOC3 (Correctseq’s CS-121) for hyperlipidemia (the 6th from the right) has successfully completed dosing and been discharged.
Picture: The world’s first patient of the gene-editing therapy targeting APOC3 (Correctseq’s CS-121) for hyperlipidemia (the 6th from the right) has successfully completed dosing and been discharged.

Picture: The world’s first patient of the gene-editing therapy targeting APOC3 (Correctseq’s CS-121) for hyperlipidemia (the 6th from the right) has successfully completed dosing and been discharged.

Chylomicronemia is a metabolic disorder characterized by abnormally elevated chylomicrons in the blood, associated with lipid metabolism dysfunction, leading to extremely high fasting TG levels and potentially life-threatening complications such as acute pancreatitis. It is the most severe subtype of severe hypertriglyceridemia (sHTG), including Familial Chylomicronemia Syndrome (FCS) and Multifactorial Chylomicronemia Syndrome (MCS). FCS is a rare autosomal recessive disorder caused by biallelic mutations in the Lipoprotein Lipase (LPL) gene or other key regulatory genes, with fasting TG ≥10 mmol/L (885 mg/dL) and a global prevalence of 1 in 100,000–1,000,000. MCS results from a complex interaction of genetic, lifestyle, or metabolic disorders with a prevalence as high as 1 in 600 worldwide.

Current treatments for chylomicronemia primarily aim to control fasting TG levels below the acute pancreatitis risk threshold (<5.7 mmol/L or 500 mg/dL), but available triglyceride-lowering medications are often insufficient, and very-low-fat diets are hard to maintain in a long-term manner.

Scientific studies have shown that the APOC3 protein, produced in the liver, plays a central role in TG regulation. Large-scale population analyses have shown that individuals carrying natural APOC3 loss-of-function mutations have significantly lower TG levels without adverse effects. With advances in gene-editing technologies, it is now possible to therapeutically modulate APOC3 expression at the genetic level to lower TG levels — offering a potential curative strategy for chylomicronemia and hypertriglyceridemia.

CS-121, Correctseq’s first in vivo gene-editing therapy for chylomicronemia and hypertriglyceridemia, is based on the transformer Base Editor (tBE) — a highly precise base-editing system independently developed by Correctseq’s scientific co-founders. Administered via intravenous injection, tBE is delivered via lipid nanoparticles (LNPs) to the liver and precisely edits the target APOC3 gene. It mimics beneficial natural APOC3 loss-of-function variants to downregulate APOC3 expression and effectively lower plasma TG levels. By addressing the disease at the genetic level, this therapy aims to achieve “one-time treatment, lifelong efficacy.”

CS-121 utilizing the next-generation tBE technology, which enables precise single-base correction without DNA double-strand breaks, offering superior safety over the gene-editing therapies based on CRISPR. tBE avoids potential safety risks such as p53 activation, chromosomal damage, off-target effects, and liver toxicity caused by DNA double-strand breaks. Preclinical animal studies showed excellent safety and long-term efficacy, with no off-target editing detected in various organs including liver, lungs, muscle, spleen, ovaries, heart, and kidneys.

The first patient, a 63-year-old male, received a single low-dose intravenous administration on October 18, 2025. His fasting TG levels dropped significantly within three days after the treatment, and he was discharged three days post-treatment with no treatment-related adverse events to date.

The principal investigators of the CS-121 IIT are Professor Huan Zhou and Doctor Zhili Wu from the First Affiliated Hospital of Anhui Medical University.

Correctseq, an innovative biotechnology company at the IND clinical stage, previously developed CS-101, an ex vivo gene-editing therapy that has successfully treated dozens of patients with β-thalassemia and sickle cell disease. The company is advancing the first in vivo gene-editing therapy CS-121 toward IND clinical trials and commercialization, aiming to offer “one-time treatment, lifelong efficacy” treatment for patients with chylomicronemia, hypertriglyceridemia, and other metabolic disorders.

Acknowledgments: The First Affiliated Hospital of Anhui Medical University, ShanghaiTech University, Shanghai Clinical Research and Trial Center.

About CorrectSequence Therapeutics
CorrectSequence Therapeutics (Correctseq), incubated at ShanghaiTech University, is dedicated to leveraging innovative gene-editing technologies to transform the lives of people with severe diseases. The company has developed multiple state-of-the-art base-editing systems that offer exceptional precision, minimize off-target effects, and enhance in vivo editing efficiency. Its robust pipeline spans genetic disorders, metabolic diseases, and cardiovascular conditions, with several programs already advancing toward clinical development.

For more information, visit www.correctsequence.com.

Media Contact:
Business Cooperate: BD@correctsequence.com
Clinical Trial Recruitment: CT@correctsequence.com

AgroFresh Announces New AI-Powered Imaging and Orchard Analytics Partnerships with Aerobotics and Neolithics

Integration Reinforces FreshCloud as the Industry’s Most Connected Digital Quality Ecosystem

PHILADELPHIA, Nov. 6, 2025 /PRNewswire/ — AgroFresh Solutions, Inc., a global leader in post-harvest freshness solutions, continues to expand its FreshCloud™ digital ecosystem through two strategic global partnerships. Collaborations with Aerobotics, a leader in orchard and packhouse analytics, and Neolithics™, a pioneer in AI-powered quality inspection, position FreshCloud to be the most comprehensive digital produce quality and supply chain management platform in the fresh produce industry.

By aggregating real-time data from multiple sources, FreshCloud offers more options at each step in the fresh produce supply chain for digitally integrated, quality measurements. Building on its existing partnerships with sensor innovators Rubens Technologies, Strella, and Escavox, AgroFresh continues to expand its connected sensor platform for post-harvest management. This growing ecosystem empowers growers, packers and retailers to make faster, data-backed decisions to reduce waste, improve quality, and drive profit potential.

“AgroFresh is committed to building the most holistic and connected digital platform in fresh produce,” said Bradford Warner, AgroFresh Head of Digital Solutions. “By integrating partners like Aerobotics and Neolithics, FreshCloud now connects orchard-to-packhouse intelligence like never before.”

Accurate Yield Data with TrueFruit® by Aerobotics

AgroFresh’s partnership with Aerobotics integrates multiple TrueFruit® modules into FreshCloud™, delivering AI-powered orchard and packhouse intelligence. Using computer vision and AI analysis of smartphone imagery, Aerobotics enables growers to:

  • Measure fruit size, color, and quality accurately and objectively.
  • Improve harvest planning with accurate size forecasting, blemish detection, and color grading models.
  • Monitor quality with standardized measurements, from the orchard to the packhouse.
  • View yield data in one place for informed decisions that boost packouts by an average of 1-5%, providing more than 10 times return on investment for commercial customers.

“Aerobotics has always focused on empowering growers and packers with highly accurate yield,” said James Paterson, CEO of Aerobotics. “We are excited to partner with AgroFresh, as a key leader in our industry, to offer TrueFruit® to more customers and combine the power of our technology with FreshCloud™. Together, these solutions seamlessly extend insights from the orchard into the post-harvest stage, providing continuity of data and enhancing decisions across the value chain.”

Next-Generation Quality Control with Neolithics

With Neolithics integrated into AgroFresh’s FreshCloud, packers have access to a technology that delivers quality assurance to match the speed and scale of the modern packhouse, turning inspection into a source of confidence versus risk. Neolithics’ AI-powered imaging:

  • Provides high-throughput inspection, from one kilogram per minute for berries to over six tons per hour for avocados, scanning every piece for internal and external quality.
  • Measures key parameters such as brix, acidity, and dry matter, while detecting hidden internal and surface defects.
  • Completes this process without destroying a single piece of fruit, all above 90% accuracy.

“We want to enable customers to protect their produce through high-volume, non-destructive quality inspections by reducing waste and creating greater transparency from field to shelf,” said Kate Murray, CEO of Neolithics. “We’re excited to integrate with AgroFresh and their FreshCloud ecosystem to realize our shared vision for a more sustainable, transparent food chain.”

Discover how AgroFresh and its partners are advancing digital quality innovation by connecting with us through the contact us form.

About AgroFresh
AgroFresh is a global leader in post-harvest quality and freshness solutions, dedicated to enhancing the quality and extending the shelf-life of fresh produce while reducing food loss and waste. With over 40 years of innovation, AgroFresh addresses supply chain challenges from all angles, offering a full suite of integrated storage, packing line, and digital solutions. AgroFresh empowers growers, packers, and retailers to deliver fresh, quality, and sustainable produce from harvest to home. Learn more at www.agrofresh.com.

About Aerobotics
Powered by Aerobotics’ industry-leading computer vision, TrueFruit® is a comprehensive suite of AI tools to help fruit companies better measure and estimate their yield. TrueFruit® uses smartphone imagery and machine learning to accurately size and grade fruit, providing precise and objective measurements to aid forecasting and estimation. TrueFruit® is used by leading fruit companies worldwide, helping improve packouts and enhance returns. Learn more at aerobotics.com.

About Neolithics
Neolithics™ is an AI agri-tech company leveraging advanced food science and optical sensing technology to revolutionize fresh produce inspection. Named for the Neolithic period, the dawn of agriculture, Neolithics brings that same spirit of transformation to modern food systems. Its flagship technology, in use by Neolithics Light devices, uses AI and optical sensors to deliver fast, accurate, and non-destructive quality analysis in real time, helping reduce food waste, ensure food safety, and improve efficiency across production environments. Learn more at www.neolithics.ai.