BEIJING, Nov. 4, 2025 /PRNewswire/ — Grit Biotherapeutics Co., Ltd. (“Grit Bio“), a leading clinical-stage biopharmaceutical company pioneering next-generation immunotherapies, today announced that its groundbreaking GT801 in vivo CAR-T program has been selected for an oral presentation at the upcoming 67th American Society of Hematology (ASH) Annual Meeting, to be held December 6–9, 2025, in Orlando, Florida, USA.

The abstract, titled “Precision In Vivo CAR-T Generation via CLAMP-Enabled mRNA Delivery: Toward Scalable and Translatable Cell Therapy,” was accepted in the CAR-T Cell Therapies: Basic and Translational session. The presentation will be delivered by Professor Pin Wang, Chief Scientific Officer of Grit Biotherapeutics, on Saturday, December 6, 9:30–9:45 AM (local time) at the OCCC – Sunburst Room (W340).

GT801 is an innovative anti-CD19 in vivo CAR-T candidate developed using T-cell-targeted lipid nanoparticles (T-LNPs) encapsulating optimized mRNA. Grit Bio leveraged the proprietary CLAMP (Controllable Ligand Attachment Modification and Purification) technology to achieve site-specific antibody conjugation and precise ligand density control. This approach allows selective T-cell targeting, minimal off-target uptake, and robust, durable CAR expression following systemic administration.

In preclinical studies, GT801 demonstrated:

1. >95% B-cell clearance in humanized PBMC mouse models at doses as low as 0.01 mg/kg;
2. >80% CAR expression across tissue-resident T cells with <1% off-target delivery to myeloid and hepatic cells;
3. >30-fold in vivo expansion of CAR-T cells with minimal cytokine release (IL-6, TNF-α), supporting the safety and feasibility of repeat dosing.

Preliminary clinical data further validate efficient CAR expression, deep B-cell depletion, and repeat-dose tolerability, highlighting GT801’s strong potential as a scalable, off-the-shelf immunotherapy candidate.

“The invitation to present at ASH 2025 highlights international recognition of Grit Bio’s leadership in advancing in vivo CAR-T innovation,” said Dr. Yarong Liu, Chairman and CEO of Grit Biotherapeutics. “Our GT801 platform represents a paradigm shift in cell therapy—transforming complex ex vivo manufacturing into a simple, repeatable, and scalable in vivo process. We are eager to share our latest clinical data and explore global partnerships that accelerate the translation of this breakthrough technology to patients worldwide.”

About Grit Biotherapeutics

Founded in 2019, Grit Biotherapeutics is an innovation-driven, late-stage biopharmaceutical company pioneering next-generation immunotherapies for patients with cancer and autoimmune diseases worldwide. The company’s R&D focuses on TIL-based therapies and in vivo/off-the-shelf cell therapies for solid tumors and hematologic malignancies. Grit’s lead product GT101, the first TIL therapy approved for clinical trials in China, is currently in Phase II pivotal studies. The company’s GT201, the world’s first membrane-bound IL-15 complex–engineered TIL product, has received IND clearance in China and the U.S.

Media Contact:

Grit Biotherapeutics Co., Ltd.
Email: BD@grit-bio.com
Website: www.grit-bio.com

Celebrating the humour, heritage, and heart at the centre of the holidays

TORONTO, Nov. 4, 2025 /PRNewswire/ — Roots, the iconic premium outdoor lifestyle brand known for its heritage leather, quality sweats, and unmistakable maple leaf spirit, proudly announces actor, writer, and producer Seth Rogen as the face of its Holiday 2025 campaign. With over five decades of rich heritage, Roots continues to bridge legacy and modern culture. Partnering with Rogen reaffirms the brand’s commitment to celebrating talent that embodies humour, authenticity and homegrown pride.

Roots Canada x Seth Rogen

Dubbed, “Anything Roots,” the campaign brings Roots humour and heart to life in a delightfully nostalgic way. Set in a warm atmosphere that plays into retro aesthetics, Rogen stars as the Roots Holiday Concierge, challenged to keep up with a slew of customer calls to solve every gifting dilemma with wit and just the right amount of Canadian charm. From frantic last-minute shoppers to confused siblings, Rogen doles out hilarious, heartfelt advice wrapped in signature Roots spirit.

“Seth Rogen embodies many of the traits associated with Roots: warmth, creativity, wittiness, authenticity and a deep sense of community,” says Leslie Golts, Chief Marketing Officer of Roots. “For over 50 years, we have celebrated people who stay true to themselves and their roots. This campaign is a tribute to the quirks, traditions, and nostalgia that make the holidays feel like home.”

Featured as the Roots Holiday Concierge, Rogen says in the campaign, “When it comes to holiday gift shopping, get them anything Roots – they’ll be psyched.”

Known as a trusted destination for thoughtful gift-giving, Roots continues to celebrate the spirit of the season through pieces that are made to last and memories to be shared. 

Brought to life through the vision of Roots Image Director, Micah Cameron in collaboration with Roots Creative Director Joey Gollish, the campaign was directed by Josh Locy, photographed by Jacq Harriet, and produced by Chelsea Pictures and Cartel with support from the Roots marketing in-house teams. Rooted in heritage but designed for today, Anything Roots captures the joyful chaos of the holidays and the beauty of staying connected across borders, generations, and traditions.

For the ‘why didn’t I think of that?’ gift idea, fans are encouraged to call the Roots Holiday Hotline at 1-855-ANY-THNG (269-8464), or by visiting select Roots locations in Canada for an interactive experience.

The Roots x Seth Rogen Holiday 2025 campaign will roll out across out-of-home placements, social media platforms, streaming platforms including Netflix, Prime Video, and Spotify, Roots retail stores and on roots.com.

Shop Rogen’s looks from the campaign, now available in-store and online, including curated gift guide picks.

About Roots

Established in 1973, Roots is a global lifestyle brand. Starting from a small cabin in northern Canada, Roots has become a global brand with over 100 corporate retail stores in Canada, two stores in the United States, and an eCommerce platform, www.roots.com, that serves many international markets. We have more than 100 partner-operated stores in Asia, and we also operate a dedicated Roots-branded storefront on Tmall.com in China. We design, market, and sell a broad selection of products in different departments, including women’s, men’s, children, and gender-free apparel, leather goods, footwear, and accessories. Our products are built with uncompromising comfort, quality, and style that allows you to feel at home with nature. We offer products designed to meet life’s everyday adventures and provide you with the versatility to live your life to the fullest. We also wholesale through business-to-business channels and license the brand to a select group of licensees selling products to major retailers. Roots Corporation is a Canadian corporation doing business as “Roots” and “Roots Canada.”

Follow along: Website: www.roots.com Instagram: www.instagram.com/roots TikTok: www.tiktok.com/@roots

Press Contact:

Nicole Legate
Director of PR and Social, Roots
nlegate@roots.com

Roots Canada x Seth Rogen

PITTSBURGH, Nov. 5, 2025 /PRNewswire/ — Mine Vision Systems (MVS), the leader in vision-driven mapping and analytics for underground mining, today announced a $12.5 million Series A financing led by Rockwell Venture Capital with a significant commitment from Condire Investors. The capital will fuel rapid execution of MVS’s product strategy and expansion of its decision-making platform for underground operations, building on strong industry momentum in 2025.

“This investment exceeded our initial target of $10 million and will enable us to accelerate our product roadmap and deliver the decision platform underground mining has been waiting for,” said Michael Smocer, CEO of Mine Vision Systems. “2025 has been a breakout year. We are proud of the partnerships we have built with many of the world’s largest and most innovative mining companies, and we are beginning to scale what’s working.”

Kent Rockwell, Founder & CEO at Rockwell Venture Capital, said: “We have partnered with MVS for years and have a front-row seat to the company’s progress. The team’s execution over the past three years has translated into real operational impact for customers. We are  enthusiastic to lead this round and support the next phase of growth.”

Ryan Schedler, Founder & Managing Director at Condire, said: “For us, this is an exciting step. We performed extensive diligence, speaking with our mining portfolio companies and other industry leaders. The feedback on MVS and FaceCapture was consistently strong. We believe MVS provides essential technology for the underground mining value chain.”

Proceeds from the round will accelerate R&D and product integration, expand deployments of FaceCapture and adjacent analytics, and strengthen customer success in key mining regions.

ABOUT MINE VISION SYSTEMS

Founded in 2015, MVS focuses on bringing vision-related technology and software algorithms to the resources mining industry. As pioneers in the underground 3D mapping space, we work worldwide to improve efficiency, safety, production, and automation in mining through unmatched data collection, insights and workflow.

Contact:
Kevin Kocak 
kevin.kocak@minevisionsystems.com

Logo – https://laotiantimes.com/wp-content/uploads/2025/11/minevisionsystems_logo_fullcolor_stacked_logo.jpg 

New AI Agent enables teams to manage tasks, projects, and internal data seamlessly from a single conversational interface.

SEOUL, South Korea, Nov. 4, 2025 /PRNewswire/ — Thinkfree, a provider of web-based productivity and AI solutions, today announced the launch of the AI Agent for its enterprise AI platform, Refinder. The new AI Agent connects multiple business applications and automates workflows through natural language commands within popular collaboration tools such as Slack and Google Chat.

With Refinder, organizations can streamline team workflows and maximize the value of their connected apps and internal data. Powered by the Model Context Protocol (MCP) standard, Refinder seamlessly integrates with popular SaaS tools including Jira, Notion, and Google Workspace. Users can now perform complex tasks from a single conversational interface without switching between multiple applications.

For example, when a user types “Schedule a meeting with the marketing team” in Google Chat, the Refinder AI Agent checks everyone’s Google Calendar, proposes the best time, creates the event, and sends invitations. In addition to scheduling, it can summarize Jira projects, track issues, update Notion pages, and handle other routine processes through natural language commands.

While many AI agents focus solely on individual productivity, Refinder is built to serve both individuals and teams. Users can create personal agents to manage tasks or automate daily workflows and teams can deploy agents in shared Slack channels or Google Chat spaces to standardize processes, streamline collaboration, and automate project-specific scenarios collectively.

“Most AI agents today focus on personal productivity. Refinder takes a broader approach. It’s a collaborative AI platform designed for both individuals and teams,” said Deekay Kim, CEO of Thinkfree. “By integrating with tools like Slack and Google Chat, Refinder enables users to move seamlessly from discovering information to taking action, all within one platform.”

Refinder also employs workspace-level Role-Based Access Control (RBAC) to ensure secure data access and controlled execution of tasks. With the AI Agent, the platform now delivers a complete workflow from enterprise search to execution, redefining how teams interact with their data and applications.

Thinkfree plans to evolve Refinder into a comprehensive AI platform that bridges knowledge management, back-office automation, and intelligent search, helping enterprises build a unified, AI-driven digital workplace.

Refinder offers a free plan, making it easy for anyone to get started and explore its capabilities.

About Thinkfree

Thinkfree is a global software company specializing in document productivity and AI solutions. Building on its leadership in online office technology, Thinkfree develops secure and scalable platforms for modern workplaces, continuously advancing intelligent collaboration tools and AI agents. Its solutions are trusted by enterprises and public institutions worldwide.

More information about Thinkfree: https://thinkfree.com/

About Refinder AI: https://refinder.ai/

Medea contact
Name: Junghoon Lee
Title: Marketing Lead
Company: Thinkfree Inc.
Email: junghoon.lee@thinkfree.com

Clear NDR^® and Stamus personnel will support both offensive and defensive cyber operations during the exercise

TALLINN, Estonia, Nov. 4, 2025 /PRNewswire/ — Stamus Networks, a global provider of high-performance network-based threat detection and response systems, today announced it will participate this week in NATO Cooperative Cyber Defence Centre of Excellence’s (CCDCOE) Crossed Swords 2025 exercise. At the invitation of the CCDCOE, the participants will use the company’s Clear NDR system and expert training delivered by Stamus personnel to improve their skills and improve their nations’ cyber defences.

Crossed Swords is a multinational live-fire exercise designed to train offensive and defensive cyberspace teams at the operational level, focusing on planning, execution, legal oversight, and coordinated recovery across military, government, and industry participants. This year’s exercise emphasizes integrated public-private cooperation and advanced adversary techniques, providing a rigorous environment for both red and blue teams to validate tactics, techniques, and procedures.

Stamus Networks’ Role
As an invited partner in the offensive-oriented Crossed Swords and its defensive-focused counterpart, Locked Shields, for more than nine years, Stamus Networks has leveraged Clear NDR to deliver personnel training and network threat detection services to teach threat hunting teams how to hunt, blue teams how to defend, and red teams how to remain undetected.

“Participating at Crossed Swords is an important responsibility for our team — and an invaluable opportunity for our team to help our allies hone their skills by observing real-world adversarial activity on the wire,” said Peter Manev, co-founder and chief strategy officer at Stamus Networks. “And through our participation, we’re able to develop and test new capabilities in Clear NDR. For example, our recently developed host outlier detection algorithms were developed for and refined at the Locked Shields exercise earlier this year.”

Why This Matters
Modern cyber operations increasingly blend technical attack tradecraft with operational and legal complexities. Exercises like Crossed Swords allow defenders to test procedures, interoperability, and decision-making under pressure. Stamus Networks’ participation supports the CCDCOE mission of improving NATO and partner cyber readiness while strengthening public–private collaboration in defending critical systems.

“The realism and effectiveness of the exercise is significantly enhanced through collaboration with academia and industry partners like Stamus Networks, who help ensure authenticity and relevance,” said Tõnis Saar, director of the NATO Cooperative Cyber Defence Centre of Excellence (CCDCOE). “These partnerships also support the integration of advanced technologies, including AI tools, into key aspects of the exercise.”

To learn more about the NATO Cooperative Cyber Defence Centre of Excellence (CCDCOE) and the Exercise Locked Shields, visit the website: https://ccdcoe.org/exercises/crossed-swords/.

About Stamus Networks
Stamus Networks is the global leader in Suricata-based network security and the creator of the innovative Clear NDR system. Providing superior network intelligence that empowers security AI platforms, Clear NDR closes visibility gaps and reduces alert fatigue, transforming raw network traffic into actionable security insights with unmatched transparency, customization, and effectiveness. Trusted by leading financial institutions, government agencies, and participants in NATO’s largest cybersecurity exercises, Stamus Networks delivers proven, high-performance network detection and response solutions. For more information visit www.stamus-networks.com.

Media Contact
Kim Schofield
Stamus Networks
kschofield@stamus-networks.com
+1 (603) 234-4000