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State Grid Jinchang Power Supply Company Launches “Warm Winter” Power Security Campaign to Safeguard Stable Operation of 26 Heating Stations

JINCHANG, China, Oct. 29, 2025 /PRNewswire/ — As the heating season approaches, State Grid Jinchang Power Supply Company has recently fully launched a special power security campaign covering heating stations across the city. Through proactive services, targeted inspections and emergency coordination, the company ensures stable power supply from the source to residents’ homes, solidifying the livelihood guarantee for people to spend the winter warmly.

It is understood that Jinchang currently has 26 centralized heating stations, which are responsible for winter heating for nearly 150,000 households and over 200 enterprises and public institutions. Stable power supply serves as the “core engine” for the operation of heating systems. To achieve all-round security, State Grid Jinchang Power Supply Company made early arrangements:

Established a “one-on-one” dedicated communication mechanism with all heating stations.

Formed 6 special service teams to conduct in-depth surveys at heating stations across the city.

Developed “one enterprise, one policy” security plans tailored to the equipment differences and load characteristics of each station.

During the inspection phase, all service teams carried out “comprehensive” safety checks on the core power distribution equipment of all heating stations, focusing on testing temperature, insulation performance and line connections. For potential hazards identified, on-site inspection reports were issued, and a ledger was established to implement “list-based management and task-closure promotion”. Up to now, special inspections of all heating stations in the jurisdiction have been completed, covering over 250 pieces of equipment and eliminating 23 potential hazards, with a rectification completion rate of 100%.

In addition, the company has extended its service chain to proactively provide technical support and value-added services:

Promote electricity price policies to help enterprises reduce electricity costs.

Assist in improving emergency plans and conduct joint drills.

Rely on the electricity consumption information collection system to conduct real-time monitoring of the line load of heating stations.

Strengthen special patrols and protection of surrounding power facilities to ensure the power grid is in a “healthy” state to meet the peak heating load, and make every effort to ensure the uninterrupted power supply for urban and rural heating.

 

Invitation To MCKL Open Day – Your Degree Pathway Starts with Us

Methodist College Kuala Lumpur (MCKL) invites all high school students, leavers and parents to join the much-anticipated Open Day happening on 21–22 November 2025, from 9:00 a.m. to 5:00 p.m., at both the Kuala Lumpur and Penang (Pykett Campus).


KUALA LUMPUR, MALAYSIA – Media OutReach Newswire – 29 October 2025 – The event is held in conjunction with MCKL’s Scholarship Week, running from 15–30 November 2025 and it is the perfect opportunity to explore your study options, secure exclusive financial aids, and take the next step toward a successful future.

Highlights of the Open Day include:

  • Career Guidance Test – Discover your strengths and career interests to find the right pathway.
  • Personalised Consultation – Meet with MCKL’s academic advisors for one-on-one guidance.
  • Scholarships, Financial Aid & PTPTN Loan – Explore up to 100% merit scholarships and other financial support options.
  • Globally Recognised Programmes – Choose to study at Scottish Qualifications Authority (SQA) approved institutions, opening doors to top universities worldwide.
  • Meet the Lecturers & Campus Tour – Get firsthand experience of MCKL’s vibrant and serene campus life and speak directly with lecturers to learn more about your preferred programme.

You can take this opportunity to register and apply on the spot, receive exclusive counselling and gain valuable insights into MCKL’s diverse range of programmes that includes Pre-University, Diplomas, American Degree Transfer, Professional Development and more as you explore your options and discover a seamless pathway towards your undergraduate studies.

At Methodist College Kuala Lumpur (MCKL), education goes beyond the classroom. With a strong reputation for academic excellence and holistic development, we continue to empower you to become competent, compassionate and globally minded leaders. We also provide pathways to wide range of degree programmes at globally recognised universities worldwide as well as prestigious local universities, thereby allowing students to progress directly into the second year of their chosen degree.

For over four decades, MCKL has remained committed to our mission of nurturing excellence for life. Whether you aspire to pursue your studies locally or abroad, MCKL provides a solid foundation to help you achieve your goals.

Do not miss out! Mark your calendars and experience how MCKL can shape your academic and personal journey.

To Know More, Make Your Appointment Today By:

Calling: KL: 03-2300 0998 | PG: 04-6888 327
Emailing: KL: admission@mckl.edu.my | PG: admission.pg@mckl.edu.my

And for MCKL Overview, please visit –

Website: www.mckl.edu.my.
Social Media – FB, Instagram, YouTube, Linkedin: @methodistcollegekl
Methodist College Kuala Lumpur (MCKL) looks forward to warmly welcoming you to our campus.

Hashtag: #mckl #openday #scholarshipweek #excellenceforlife




The issuer is solely responsible for the content of this announcement.

Methodist College Kuala Lumpur (MCKL)

Methodist College Kuala Lumpur (MCKL) was founded by the Methodist Council of Education in 1983, its campus sitting in the heart of Kuala Lumpur and branch campus in Pykett, Penang, known as the MCKL College (Penang, Pykett Campus). MCKL is now an SQA Approved Centre delivering Advanced Diplomas focusing on Business and Computing: Software Development. It also offers programmes in the pre-university pathway for subjects including Cambridge A-Level, Australian Matriculation; the American Degree Transfer, Diploma courses Digital Business, Digital Marketing, IT (Internet of Things Focused), Computer Science (data science focused), Early Childhood Education, Social Work, and Financial Technology. Over the years, MCKL has been highly recognised for its track record and gold standard achievements of its pre-university programmes and its overseas degree pathways.

For additional information, please visit the .

Agoda Data Reveals Top Honeymoon Destinations for Indian Travelers in 2025

SINGAPORE, Oct. 29, 2025 /PRNewswire/ — Digital travel platform Agoda’s latest data on the most searched honeymoon destinations reveals Indian newlyweds are chasing sunsets, islands, and immersive experiences. Goa continues to reign as the top domestic choice, while Dubai leads internationally. The surprise of the year: Vietnam’s Phu Quoc Island has seen an eightfold increase in popularity, entering the top ten rank for the first time.

India’s wedding season is just around the corner, as the monsoon season draws to a close and the cooler, more pleasant weather of winter approaches from November to January. In the coming months, wedding-related travel is set to be on the rise, with couples, families, and guests preparing to celebrate together in destinations near and far. Honeymoons, in particular, can be a significant demand driver as couples book their first trip together, and this year’s trends highlight both enduring favorites and new discoveries.

Domestically, Goa has held strong as India’s most-loved honeymoon spot for the second year running, thanks to its sun-soaked beaches, boutique resorts, and vibrant culinary scene. Meanwhile, Udaipur, the “City of Lakes,” climbed to second place in 2025, appealing to couples with its royal charm and serene lakeside views. Mumbai ranks third, while Jaipur and the Andaman & Nicobar Islands complete the top five. The Andamans are emerging as an increasingly sought-after island escape closer to home, making its debut in the top five rank for honeymooners this year.

Internationally, Dubai remains the top choice, drawing couples with its luxury, desert adventures, and glamorous cityscape. Phuket and Bangkok follow close behind, while Bali and Pattaya continue their tropical pull. But it’s Phu Quoc Island that’s stealing the spotlight this year, climbing from outside the top 10 in 2024 to sixth place in 2025 with nearly 700% growth in search interest – highlighting Indian travelers’ appetite for fresh and affordable Southeast Asian escapes.

Commenting on the data, Gaurav Malik, Country Director, Indian Subcontinent & Indian Ocean Islands at Agoda said, “Honeymoons are among the most meaningful trips couples take, and Indian travelers are showing a growing preference for destinations that offer both romance and discovery. From classic getaway destinations like Goa and Bali to rising stars like Phu Quoc, beach and island getaways are winning hearts and setting the stage for a lifetime of happiness for newlyweds. Agoda’s wide range of stays and activities helps couples create trips as unique as their journey together.”

Whether it’s watching a sunset on a Goan beach, dining by the lakeside in Udaipur, or exploring the beauty of the island of Phu Quoc, Agoda helps couples discover their ideal romantic escape. With over 6 million holiday properties, more than 130,000 flight routes, and over 300,000 activities available, travelers can plan and book their dream honeymoon in just a few clicks.

Find the best deals on Agoda’s mobile app or visit Agoda.com for more information.

 

Canon Envisions a ‘Future-Ready Malaysia’ at Think Big Klang Valley Series 2025

Forum invites businesses to Lead with Smart Tech towards Innovation, Resilience, and Growth in today’s digital-first economy


KUALA LUMPUR, MALAYSIA – Media OutReach Newswire – 29 October 2025 – Canon today announced its upcoming Think Big Klang Valley Series, happening on 12 November 2025 at the Sheraton Petaling Jaya Hotel. Under the theme of ‘Future-Ready Malaysia: Innovation, Resilience, Growth’, the forum will bring together industry leaders and policymakers to explore how artificial intelligence (AI) and cloud technologies can power productivity, attract investments, and elevate local talent in Malaysia’s rapidly digitalising economy.

Canon announces Think Big Klang Valley to conclude Think Big Series in Malaysia
Canon announces Think Big Klang Valley to conclude Think Big Series in Malaysia

This thought leadership forum in Kuala Lumpur brings together insights from the Think Big events in 2025 across Malaysia—generated from sessions in Johor Bahru, Penang, and Putrajaya—where business leaders convened to discuss the challenges and opportunities shaping the nation’s economic and business landscape.

Malaysia’s digital economy is projected to contribute 25.5% to the national GDP by 2025, with investments in AI and digital infrastructure surging by 125% in the second quarter of 2025 alone. Building on this momentum, the Malaysia Budget 2026 has also allocated RM5.9 billion to further strengthen AI research, development and innovation via cross-ministerial efforts — signalling a market poised for hyper-growth.

“The rapid rise of AI and cloud technologies is shaping how organisations across Asia operate and compete, with Malaysia rapidly emerging as one of the regional leaders in this transformation,” said Norihiro (Nick) Katagiri, Senior Vice President, Regional Digital Printing and Business Solution Operations, Canon Singapore. “Think Big Malaysia serves as a critical platform to equip business leaders with the practical blueprint to harness the full power of AI and cloud technologies in the workplace, while empowering long-term growth and resilience in a digital-first economy.”

Next-Gen Solutions and Innovative Insights for Future-Ready Economies
The Klang Valley Series of Think Big Malaysia is set to deliver expert insights through a fireside session and panel discussion. These sessions will guide business leaders on maximising the opportunities presented by Malaysia’s growing digital infrastructure. Executives will also gain strategic direction for leveraging integrated solutions to mitigate market challenges and secure long-term competitive advantage.

The event’s speaker lineup will feature notable government representatives and key industry leaders from Malaysia’s digital and finance sectors, including the Minister of Digital for Malaysia, YB Gobind Singh Deo, and the Chief Economist of Affin Bank Berhad, Alan Tan. Complementing the leadership discussions, Canon will host a dedicated solutions showcase to highlight smart technologies aimed at helping businesses accelerate digital transformation, streamline workflows, and create greater value. These solutions include:

  • imageFORCE: Canon’s next-generation multi-function device (MFD) series which integrates intelligent automation and advanced security for seamless digital workflows. It features AI-assisted smart maintenance, utilising machine learning to predict component lifespan and ensure maximum uptime.
  • Antelope®: An AI-powered document management solution which transforms raw documents—including printed and handwritten text—into actionable insights by accurately capturing data, generating quick summaries, and extracting key terms for faster workflow.
  • VisualAI: An AI-driven operational platform which delivers real-time visibility across people, material, and processes. Through the analysis of on-ground activities and seamless integration with backend systems and IoT devices, the solution creates a safer, more productive and efficient workspace.

“Malaysia’s growing strength and leadership in AI and cloud infrastructure reflect a powerful national commitment to building a digital-first economy. As the country attracts major investments and accelerates smart technology adoption across industries, businesses here have an incredible opportunity to reinvent the way they work,” said Masato Yoshiie, President and CEO, Canon Marketing Malaysia. “We are dedicated to helping companies turn these advancements into practical value—delivering smart, integrated solutions that maximise business efficiency, enhance collaboration, and support them in building a future-ready Malaysia.”

For more information on Think Big Malaysia, please visit: https://bcbs.asia.canon/en/discover/events/think-big/future-ready-malaysia-innovation-resilience-growth

About Think Big Leadership Business Series

The Think Big Leadership Business Series, an initiative by Canon, is designed to inspire and empower business leaders with forward-looking strategies and actionable insights. First launched in Singapore in 2010, the platform helps organisations navigate today’s fast-evolving business landscape by demonstrating how innovation and technology can drive sustainable growth.
Hashtag: #Canon

The issuer is solely responsible for the content of this announcement.

About Canon Singapore Pte. Ltd.

Canon is a global leader in photographic and digital imaging solutions. Canon Singapore Pte. Ltd. is the headquarters for South & Southeast Asia driving sales, marketing and service strategies. Besides handling the domestic market, the company covers 22 other countries and regions. The parent company Canon Inc. has a global network of more than 300 companies and employs about 170,000 people worldwide. Canon is guided by its kyosei philosophy that focuses on living and working together for the common good.

More information is available at .

Ready Server Launches VPS Hosting Service to Empower Growth of Businesses in Singapore

Ready Server’s new VPS service offers unmetered access, per-hour billing, and enterprise-grade performance for growing businesses.

SINGAPORE, October 29, 2025 /PRNewswire/ — Ready Server, a server hosting service provider from Singapore, has introduced a new Virtual Private Server (VPS) service aimed at tackling the prohibitive costs and complexity often faced by growing enterprises. With its unique per-hour billing and unmetered internet access under a fair-use policy, the new VPS hosting service provides businesses of all sizes with the financial agility to scale instantly, ensuring zero waste and predictable expenditure without worrying about bandwidth caps or unexpected cloud fees.

Ready Server director Alan Woo at his company's data centre in Singapore
Ready Server director Alan Woo at his company’s data centre in Singapore

Growth of Digital Economy Drives New Opportunities for Smarter Hosting Services

Singapore’s digital economy continues to thrive, contributing S$128.1 billion (18.6% of GDP) in 2024, up S$12 billion from the previous year. As industries such as finance, manufacturing, and professional services accelerate their digital transformations, demand for robust, scalable technology infrastructure has surged, creating new opportunities for smarter hosting solutions.

While public cloud platforms offer agility, small businesses often face additional, sometimes hidden costs from repeated deployments, data transfers, and idle virtual machines. Many also struggle to ensure machine compatibility and timely updates across applications. This infrastructure complexity diverts valuable time and resources away from innovation.

“Financial agility is becoming the new competitive edge in our digital-first economy,” said Alan Woo, Director of Ready Server. “Many small and growing businesses struggle with the rigid pricing and hidden costs of traditional cloud platforms. Our innovative per-hour billing and unmetered access give them the flexibility to manage resources and costs on their own terms, thus giving Singaporean enterprises the granular control over expenditure they need to innovate without capital risk.”

Strengthening the Nation’s Digital Backbone with High-Performance Hosting

Designed to handle diverse workloads, the hosting service enables developers and enterprises to build, test, and scale with confidence. From developers creating new apps to SMEs running online stores, and large organisations managing critical systems, Ready Server’s VPS hosting service ensures stable, secure performance.

The hosting service operates from Ready Server’s state-of-the-art data centres in Singapore, featuring more than 5,000 CPU cores for scalable performance and 100TB of ultra-fast SSD storage for maximum speed and reliability.

Real-Time Control Across Devices

Businesses can take full control of their operations through the mobile app, available on both Apple and Android devices. This allows them to conveniently manage and monitor their servers from anywhere, at any time.

Flexible and Transparent Pricing

The new VPS hosting service is available with flexible, per-hour billing starting at S$0.00694/hour (approximately S$5/month). This provides businesses with a truly flexible, risk-free pathway to high-performance computing that ensures zero wastage and the freedom to start projects anytime without committing to a long-term plan.

To get started, download the app and sign up and claim free credits to try the VPS service at  https://www.readyserver.sg/download-mobile-app/ or learn more at https://www.readyserver.sg/.

About Ready Server

At Ready Server, we’re building a better VPS hosting experience for developers, entrepreneurs, and tech enthusiasts. Our mission is to provide fast, reliable, and affordable VPS solutions that empower you to focus on what matters most – building and growing your online projects.

Forrester’s 2026 B2C Marketing, CX, & Digital Business Predictions: One-Third Of Brands Will Erode Customer Trust Through Self-Service AI

SINGAPORE, Oct. 29, 2025 /PRNewswire/ — According to Forrester’s (Nasdaq: FORR) 2026 B2C marketing, customer experience, and digital business predictions, the rapid adoption of generative AI is exposing fragmented vendor ecosystems and increasing consumer skepticism. In 2026, a third of companies will harm experiences with frustrating AI self-service. The pressure to cut costs will cause companies to deploy customer-facing genAI chatbots and virtual agents prematurely — and in contexts where they’re unlikely to succeed. This will erode the brand and customer experience, harming both customer acquisition and retention. As customers’ expectations continue to rise and tolerance for surface-level efforts fades, trust and value will become the guiding beacons for consumer marketing, customer experience (CX), and digital leaders.

Forrester’s Predictions reports deliver forward-looking insights into signals and trends that empower business leaders and their teams to think beyond conventions and ignite bold ideas in the year ahead. Forrester’s consumer marketing, CX, and digital business predictions cover topics including: B2C marketing; customer experience; consumers; digital commerce; media and advertising; marketing agencies; and trust and privacy.

Key highlights from Forrester’s 2026 B2C marketing, CX, and digital business predictions include:

  • AI-driven privacy breaches will lead to a 20% surge in class-action lawsuits. A convergence of forces — growing privacy awareness, regulation, data breaches, and AI — will drive a spike in US consumer class-action lawsuits. As privacy concerns continue to challenge the AI industry, consumers and law firms will expand their focus from tracking pixels to AI applications and the companies that use them.
  • Advertisers will cut display ad budgets by 30% as consumers leave the open web. Despite consumers’ skepticism about genAI, they will continue to turn to AI-generated summaries and chat interfaces designed to return answers. This will shrink addressable audiences on the open web, and click-through rates will decline. As a result, leading advertisers will cut display ad budgets by 30% and redirect spending to more entertainment-driven content platforms, such as connected TV, streaming audio, and social video.
  • A third of consumers will opt for offline (over online) brand experiences. Forrester’s 2025 data shows that 52% of US online adults actively pursue in-person, tactile experiences — driven by a desire for richer, more sensory interactions that digital channels can’t replicate. Digital experiences aren’t going away, but consumers in 2026 will more intentionally choose to disconnect online to connect offline.

“In 2026, as consumer expectations rise, and tolerance for surface-level efforts fades, leaders across consumer marketing, customer experience, and digital business should work together to deliver experiences that align with their brand promise,” said Sharyn Leaver, chief research officer at Forrester. “Measures such as enhancing personalization that prioritizes relevance and value and integrating AI through a customer-centric lens will be table stakes for brands to earn their customers’ loyalty.”

Resources:

About Forrester
Forrester (Nasdaq: FORR) is one of the most influential research and advisory firms in the world. We empower leaders in technology, customer experience, digital, marketing, sales, and product functions to be bold at work and accelerate growth through customer obsession. Our unique research and continuous guidance model helps executives and their teams achieve their initiatives and outcomes faster and with confidence. To learn more, visit Forrester.com. 

 

Netcore Cloud Achieves CMMI Level 3 Appraisal

MUMBAI, India, Oct. 29, 2025 /PRNewswire/ — Netcore Cloud, a global leader in AI-powered customer engagement and personalisation, today announced that it has been appraised at level 3 of ISACA’s Capability Maturity Model Integration (CMMI®). The appraisal was performed by Equalitas Certifications Limited.

CMMI is a proven, outcome-based performance model and the globally accepted standard for improving capability, optimizing business performance and aligning operations to business goals.

An appraisal at Maturity Level 3 indicates the organization is performing at a ‘defined’ level. At this level, processes are well characterized and understood, and are described in standards, procedures, tools and methods. The organization’s set of standard processes, which is the basis for Maturity Level 3, is established and improved over time.

“Organizations worldwide are harnessing CMMI to elevate their business performance to new heights, creating a sustainable competitive advantage in the process,” says Ron Lear, VP, Frameworks and Models at ISACA. “We commend Netcore Cloud on achieving this CMMI appraisal level and demonstrating their ability as a high-performing organization.”

“Achieving this CMMI appraisal is more than just a certification; it’s a reflection of our relentless pursuit of perfection and our deep commitment to our customers,” said Kuldeep Sengar, Group CTO of Netcore Cloud. “This milestone assures our clients that their trust in us is well-placed and validates our eligibility to engage with top-tier clients worldwide.”

This achievement builds on the company’s existing compliance with global standards and complements Netcore Cloud’s robust data sensitivity benchmarks, assuring customers that their information is handled with the utmost care and security. By integrating best practices from CMMI with its existing quality and security frameworks, Netcore Cloud is equipped to expand its business into new, highly regulated markets and demonstrate an elite level of operational maturity.

For more information about Netcore Cloud’s CMMI appraisal and its commitment to quality, please visit https://netcorecloud.com/

About Netcore Cloud

Netcore Cloud, a global leader in marketing technology, empowers marketers with its comprehensive Customer Engagement and Experience Suite to create personalized, omnichannel experiences. Leveraging AI to integrate customer data, Netcore enables targeted segments and meaningful digital interactions. Trusted by over 6,500 brands across sectors like Ecommerce, Retail, Banking and Financial Services, Media and Entertainment, and Travel, its marquee clients include Walmart, Unilever, Tommy Hilfiger, Domino’s, McDonald’s, Pizza Hut, and Crocs. For more information, visit netcorecloud.com

Logo: https://laotiantimes.com/wp-content/uploads/2025/10/netcore_logo.jpg

 

Total Investment of Approx. USD 11.6 Million in TB and NTD R&D Projects With Partners Including Fujifilm, Stop TB Partnership, and the Ohio State University

TOKYO, Oct. 29, 2025 /PRNewswire/ — The Global Health Innovative Technology (GHIT) Fund announced today a total investment of approximately JPY 1.73 billion (USD 11.6 million1) in four R&D projects for the development of diagnostics and a vaccine for tuberculosis (TB), neglected tropical diseases (NTDs), and malaria.2 

Investment of JPY 390 Million (USD 2.6 million1) to Advance a Novel Rapid Diagnostic for Tuberculosis
Tuberculosis (TB) remains one of the world’s most devastating infectious diseases, affecting over 10 million people and causing 1.3 million deaths annually.3 In resource-limited settings, over 3 million people go undiagnosed each year due to the lack of suitable, accessible diagnostic tools4—particularly at the point of first contact with the healthcare system. Severely ill patients and children, who often struggle to produce sputum, are especially at risk of being missed by routine diagnostics. To help address this gap, the GHIT Fund is investing JPY 390 million (USD 2.6 million1) in a global partnership aimed at assessing and introducing an innovative TB diagnostic. This project is being led by the United Nations Office for Project Services (UNOPS) hosted organization Stop TB Partnership, in collaboration with FUJIFILM Corporation, the Liverpool School of Tropical Medicine, and research institutions in Cameroon, Nigeria, and Germany. The investment builds on a prior GHIT-supported project that received approximately JPY 600 million (USD 4.0 million1) between 2016 and 2023 and seeks to bring a highly sensitive urine-based rapid test progressing toward implementation.

The project will evaluate the performance and feasibility of FUJIFILM SILVAMP TB LAM II, a rapid test developed by Fujifilm to detect urinary LAM antigens, along with a urine concentration device (UCD). This innovative diagnostic approach eliminates the need for sputum collection and has the potential to significantly improve diagnostic accuracy for a broad range of people—including those living with or without HIV, severely ill individuals, and children. By enabling earlier and more accessible diagnosis, particularly in underserved settings, this project aims to reduce diagnostic delays and disparities, help limit the spread of TB, and ultimately support global efforts to end the disease.

JPY 681 million (USD 4.5 million1) Investment in a Phase I Clinical Study of a Leishmaniasis Vaccine
Leishmaniasis is a parasitic disease transmitted by sandflies and is recognized by the World Health Organization (WHO) as an NTD. The GHIT Fund will invest JPY 681 million (USD 4.5 million1) in Phase I clinical trials of this promising vaccine, in a project jointly conducted by the Ohio State University and Nagasaki University. The project will evaluate the safety and immunogenicity of the investigational vaccine in healthy adults living in endemic regions of Brazil and Kenya. In addition, on July 25, 2025, the U.S. Food and Drug Administration (FDA) approved the Investigational New Drug Application (IND) to initiate human clinical trials. This milestone represents a significant step forward in the fight against leishmaniasis and will accelerate product development and early access.

In addition, the GHIT Fund will invest a total of approximately JPY 666 million (USD 4.4 million1) in the following two R&D projects:
(1) Product development project for new rapid diagnostic test for strongyloidiasis by Drugs & Diagnostics for Tropical Diseases (DDTD), Medical & Biological Laboratories Co., Ltd. (MBL), IRCCS Sacro Cuore Don Calabria Hospital, QIMR Berghofer Medical Research Institute, Fundacion Mundo Sano, and Big Eye Diagnostics, Inc. (BEDx) 
(2) Target research project for malaria diagnostics by Ehime University, Institute of Tropical Medicine (NEKKEN) Nagasaki University, and Universiti Malaysia Sabah

Please refer to Appendix 1 for detailed descriptions on these projects and their development stages. The four projects funded in this round bring together partners from a total of 11 countries. Since its inception, the GHIT Fund has worked with more than 190 research and development partners, including more than 130 overseas institutions. The GHIT Fund serves as a bridge connecting pharmaceutical companies, universities, and research institutes in Japan with their counterparts around the world.

As of September 30, 2025, the GHIT Fund has invested in 42 projects, including 17 discovery projects, 14 preclinical projects, and 11 clinical trials.6 The total amount of investments since 2013 is JPY 41.0 billion (USD 275 million1) (Appendix 2).

1 USD1 = JPY148.81, the approximate exchange rate on September 30, 2025.
2 These awarded projects were selected and approved as new investments from among proposals to RFP2023-002, RFP2024-001, and RFP2025-001 for the Product Development Platform and the Target Research Platform, which were open for applications from June 2023 to July 2025.
3 WHO: https://www.who.int/news-room/fact-sheets/detail/tuberculosis 
4 Stop TB Partnership https://www.stoptb.org/missing-tb-millions 
5 WHO: https://www.who.int/news-room/fact-sheets/detail/leishmaniasis 
6 This number includes projects in the registration phase.

The GHIT Fund is a Japan-based international public-private partnership (PPP) fund that was formed between the Government of Japan, multiple pharmaceutical companies, the Gates Foundation, Wellcome, and the United Nations Development Programme (UNDP). The GHIT Fund invests in and manages an R&D portfolio of development partnerships aimed at addressing neglected diseases, such as malaria, tuberculosis, and neglected tropical diseases, which afflict the world’s vulnerable and underserved populations. In collaboration with global partners, the GHIT Fund mobilizes Japanese industry, academia, and research institutes to create new drugs, vaccines, and diagnostics for malaria, tuberculosis, and neglected tropical diseases.
https://www.ghitfund.org/en

Appendix 1. Project Details 

ID: G2023-212

Project Title

Multi-site field trial of the FUJIFILM SILVAMP TB LAM Ⅱ including the diagnostic accuracy of a urine concentration device

Collaboration

Partners

1. Stop TB Partnership (Switzerland)

2. FUJIFILM Corporation (Japan)

3. Liverpool School of Tropical Medicine (LSTM) (UK)

4. Center for Health Promotion and Research (CHPR) (Cameroon)

5. Friends for International TB Relief (FIT) (Germany)

6. Zankli Research Centre, Bingham University Nigeria (ZRC) (Nigeria)

Disease

Tuberculosis

Intervention

Diagnostics

Stage

Product Validation

Awarded Amount

JPY 390,000,000 (USD 2.6 million)

Status

Continued project

Summary

[Project objective]

The primary objective of the project is to provide evidence on the performance of Fujifilm’s redesigned SILVAMP TB LAM II assay as well as a urine concentration device (UCD) which is expected to further increase sensitivity especially in HIV-negative individuals to obtain a WHO policy recommendation with strengthened evidence based on the operationalization, costing and feasibility studies to be conducted on this project.

[Project design]

The project team will prospectively evaluate the performance of the SILVAMP TB LAM Ⅱ assay as well as a urine concentration device across multiple sites in Cameroon, Nigeria and Vietnam. The project team will evaluate test performance among PLHIV and HIV-negative adults as well as children irrespective of HIV co-infection. Operationalization, costing and feasibility of the assay will also be addressed.

Project Detail

https://www.ghitfund.org/investment/portfoliodetail/detail/246/en

ID: G2024-101

Project Title

Evaluation of the Safety and Immunogenicity of the cGMP LmCen-/- Vaccine in Phase I Clinical Trials

Collaboration

Partners

1. The Ohio State University (USA)

2. Nagasaki University (Japan)

Disease

Leishmaniasis

Intervention

Vaccines

Stage

Clinical Phase I

Awarded Amount

JPY 681,063,113 (USD 4.5 million)

Status

Continued project

Summary

[Project objective]

Objective 1: Conduct a Phase I clinical trial to evaluate the safety and immunogenicity of the LmCen-/- vaccine in healthy volunteers in Brazil (New World)

Objective 2: Conduct a Phase I clinical trial to evaluate the safety and immunogenicity of the LmCen-/- vaccine in healthy volunteers in Kenya (Old World)

[Project design]This project is a continuation of the GHIT-funded project G2018-201 to advance clinical development of the LmCen-/- vaccine. During the previous funding period, the project team successfully accomplished the goals of the project by:

1) Validate the safety and efficacy of a GLP-grade LmCen-/- vaccine produced by Gennova Biopharmaceuticals under cGMP conditions using preclinical animal models,

2) Produce a GMP master cell bank (MCB) and a GMP working cell bank (WCB) of LmCen-/- parasites,

3) Establish cGMP manufacturing of the LmCen-/- vaccine,

4) Complete preclinical toxicology studies in accordance with regulatory guidelines using a GLP LmCen-/- vaccine produced from an engineering run of the cGMP cell bank, and

5) Finalize the IND package for the LmCen-/- product for submission to regulatory authorities.

In the current project, the project team proposes to evaluate the safety of the LmCen-/- vaccine in healthy volunteers living in leishmaniasis-endemic countries, Brazil and Kenya, where other factors such as subclinical nutritional deficiencies and co-infections, such as diarrhea, malaria, Chagas disease (in Brazil) and helminth infections, are common and have been documented to impact vaccine safety and immunogenicity.

Project Detail

https://www.ghitfund.org/investment/portfoliodetail/detail/247/en 

ID: G2025-101

Project Title

Strongyloides stercoralis Rapid Test Plus (SsRT+): A new rapid diagnostic test with improved ease of use to support WHO strongyloidiasis control programs.

Collaboration

Partners

1. Drugs & Diagnostics for Tropical Diseases (DDTD) (USA)

2. Medical & Biological Laboratories Co., Ltd. (MBL) (Japan)

3. IRCCS Sacro Cuore Don Calabria Hospital (Italy)

4. QIMR Berghofer Medical Research Institute (Australia)

5. Fundacion Mundo Sano (Spain)

6. Big Eye Diagnostics, Inc. (BEDx) (USA)

Disease

Strongyloidiasis (Soil-transmitted helminth)

Intervention

Diagnostic

Stage

Product Design

Awarded Amount

JPY 566,596,199 (USD 3.8 million)

Status

New

Summary

[Project objective]

The overarching goal of this project is to deliver an easy-to-use, low-cost point-of-care test to detect S. stercoralis infection. Our new test, termed S. stercoralis Rapid Test Plus (SsRT+), will be an improved version of SsRapid, which was developed and validated by our Consultant, Prof. R. Noordin, and has been shown to be 80-97% sensitive and 90-100% specific in a series of laboratory and field studies. A first SsRT+ prototype has already been generated, which showed diagnostic performance comparable to, or better than, SsRapid. SsRT+ will be fully optimized in this project to meet all key criteria of the new TPP for S. stercoralis diagnostics.

[Project design]Objective-1: This first activity aims to review the optimal use case(s) and define the key experimental data to be generated with SsRT+ to align with the WHO strongyloidiasis control programs. We will also finalize the study plans for the field evaluations in Australia and Argentina and complete a business/commercialization plan.

Objective-2: Having access to high-quality antigens and positive control antibodies is key for efficient test development, optimization, and manufacturing under ISO-13485:2016 standards. As for all our other GHIT Fund projects, MBL will be entrusted with the production of high-quality recombinant NIE and IgG4-anti-NIE. 

Objective-3: The SsRT+ prototype available at the outset of G2025-101 will be fully optimized, according to all key criteria listed in the TPP for S. stercoralis diagnostics, including sensitivity, specificity, time to result, result stability, reproducibility (CV values), and cost. Since the precursor of SsRT+, SsRapid, already meets most of the TPP criteria, we consider this a very realistic objective.

Objective-4: Prof. R. Noordin of Universiti Kebangsaan Malaysia (UKM), who has developed and validated SsRapid in numerous laboratory and field studies, and Prof. D. Buonfrate of IRCCS Sacro Cuore Don Calabria Hospital, who has previously run an in-depth diagnostic accuracy study involving SsRapid, will independently evaluate the diagnostic performance of SsRT+ to demonstrate that it complies with the TPP and is not inferior to SsRapid.

Objective-5: Once validated for TPP-compliant performance in the laboratory, SsRT+ will be evaluated in two field studies in Australia and Argentina, conducted by the groups of Prof. D. Gray of QIMR Berghofer and Prof. A. Krolewiecki of Mundo Sano, respectively.

Objective-6: An ISO-13485:2016 compliant automated manufacturing process commensurate with the anticipated demand will be developed by DDTD, modeled on the one we successfully put in place for our Onchocerciasis rapid test in the GHIT Fund project G2023-111, and subsequently validated by BEDx through production of several pilot lots and quantification of inter-lot consistency.

Project Detail

https://www.ghitfund.org/investment/portfoliodetail/detail/248/en 

ID: T2024-276

Project Title

Development of Ultrasensitive and Robust Malaria Rapid Diagnostic Tests Using de novo Designed Antigen Binders

Collaboration

Partners

1. Ehime University (Japan)

2. Institute of Tropical Medicine (NEKKEN) Nagasaki University (Japan)

3. Universiti Malaysia Sabah (Malaysia)

Disease

Malaria

Intervention

Diagnostics

Stage

Concept Development

Awarded Amount

JPY 99,670,808 (USD 0.6 million)

Status

New

Summary

[Project objective]

Current malaria Lateral Flow Assays (LFAs) use antibodies as their capture and detection reagents. The limited sensitivity of LFAs in part reflects the relativity modest affinities of typical antibodies for their target proteins. In addition, the identification of antibodies that target related proteins with high specificity is time-consuming and uncertain of success. A technology that replaces monoclonal antibodies could thus have a transformative impact on the development of new diagnostics. We propose to develop novel protein-based affinity reagents that enable the creation of rapid diagnostic tests (RDTs) that diagnose infection with Plasmodium falciparum, non-falciparum malaria parasites, and the emerging pathogen Plasmodium knowlesi with sensitivities that considerably exceed existing alternatives. Our work will result in affinity reagents that integrate directly into the existing infrastructure for the creation of LFAs, the technology used in rapid COVID tests. The products of this project can thus be rapidly scaled to impact malaria treatment worldwide. As part of this project, we will validate our approach using clinical samples. If successful, the diagnostics resulting from our collaboration will possess enhanced sensitivity, greater shelf stability, lower cost, and the elimination of test failure due to parasite mutations, four improvements that have been identified as critically important by the World Health Organization (WHO) for the management of malaria. Success in this project will establish a general-purpose platform for the rapid development of highly sensitive diagnostic assays. In addition to its impact on malaria diagnosis and treatment, this project will thus provide proof-of-concept for a novel platform technology enabling the development of rapidly scalable diagnostics for novel infectious diseases. Our overall goals are thus to develop new protein-based affinity reagents that can improve the sensitivity of malaria LFAs, and to extend malaria LFAs to include diagnosis of infection with P. knowlesi.

[Project design]Our overall strategy is to replace the antibodies that are used in conventional LFAs with computationally designed binders based on the monobody scaffold. The nanomolar (nM) affinities of most antibodies limit the sensitivity of LFAs. To circumvent this limitation, we will use de novo protein design to identify numerous monobody binders for a target malaria antigen of interest. We will then link monobodies together to generate bivalent binders for the malaria antigens. This strategy makes use of the well-known principle of avidity, in which linear improvements in binding energy yield exponential improvements in dissociation constants: both empirical evidence and simple calculations indicate that combining monobody binders with 10-100 nM KD values should yield multivalent binders with KD values in the pM regime. Importantly, this strategy is made possible by the unique ability of computational design to deliberately target multiple, distinct sites on the target protein. We will quantify the binding affinities and cross-reactivity of bivalent monobodies and confirm that they possess the properties required for use in an LFA. Finally, we will assess the performance of the resulting capture and detection reagents in prototype LFAs.

Project Detail

https://www.ghitfund.org/investment/portfoliodetail/detail/249/en 

*All amounts are listed at an exchange rate of USD1 = JPY148.81, the approximate exchange rate on September 30, 2025.

Appendix 2. Investment Overview (as of September 30, 2025)

Investments to date
Total investments: 41.0 billion yen (USD 275 million1)
Total invested projects: 141 (42 active projects and 99 completed projects)

To learn more about the GHIT Fund’s investments, please visit
Investment Overview: https://www.ghitfund.org/investment/overview/en
Portfolio: https://www.ghitfund.org/investment/portfolio/en
Advancing Portfolio: https://www.ghitfund.org/investment/advancingportfolio/en
Clinical Candidates: https://www.ghitfund.org/investment/clinicalcandidates/en 

For more information, contact:
Nancy Moss at +1-908-606-8940 or nmoss@burness.com
Mina Ohata at +81-36441-2032 or mina.ohata@ghitfund.org