MELBOURNE, VICTORIA – News Direct – 1 December 2022 – Alto Metals Ltd (ASX:AME) managing director Matt Bowles joins Proactive to discuss more high-grade gold returned in RC drilling at the Sandstone Gold Project’s Indomitable camp in WA. The explorer defined mineralisation over 2.5 kilometres and intersected a high-grade gold structure. Bowles says maiden regional drilling is underway at the historic Oroya Mine, where previous mining focused on bonanza-style mineralisation within the reef and much of the surrounding mineralisation was left unmined.

Hashtag: #Alto

The issuer is solely responsible for the content of this announcement.

SINGAPORE – Media OutReach – 1 December 2022 – ALR Technologies SG Ltd (“ALRT”) (OTCQB: ALRTF), the diabetes management company, today announced it has entered into a co-branded distribution agreement (the “Agreement”) with Covetrus, Inc. (“Covetrus”), a global leader in animal-health technology and services, for ALRT’s GluCurve Pet CGM, a continuous glucose monitoring (“CGM”) system for diabetic cats and dogs. The GluCurve Pet CGM is the first and only continuous glucose monitoring system designed for diabetic cats and dogs and sold directly to veterinarians.

“After meeting with many of the largest animal-health companies, Covetrus stood out as the clear choice as our partner to launch the GluCurve Pet CGM,” said Sidney Chan, chairman and CEO of ALRT. “Covetrus is uniquely suited for the sale and distribution of the GluCurve Pet CGM because of their industry leading service organization and differential go-to-market strategy that will help drive GluCurve to become the new standard of care for millions of diabetic animals around the world.”

According to studies^1,2, 1 in 300 dogs and 1 in 175 cats have diabetes and until now, treating them could be a challenge for pet parents and veterinarians. The GluCurve records blood sugar levels every 3 minutes for up to 14 days, readings are displayed for the pet owner in the GluCurve app for iOS and Android and uploaded to a veterinary patient management web portal. In the web portal, the data are analyzed and organized into time saving graphs and tables, along with additional features such as glucose curve comparisons and overlays, insulin dose calculators, best practice guidelines, and more.

“We welcome the opportunity to bring innovative technologies and devices, such as the GluCurve Pet CGM, to market to help animal health professionals battle a progressive but often manageable disease such as diabetes, in new and innovative ways,” said Cesar França, president, Global Proprietary Brands at Covetrus. “Veterinarians and their patients are our first priority and bringing products and technology to our customers that improve access, reduce burden and enhance care are the cornerstones of our mission.”

Under the terms of the Agreement, Covetrus will have the exclusive rights to sell ALRT’s GluCurve Pet CGM as a co-branded product to veterinary clinics throughout the U.S., Brazil, United Kingdom, the European Union, and various other countries globally. Sales in the U.S. are expected to commence by the end of 2022.

The quantity of available units will ramp up monthly to support a full U.S. launch followed by a global launch as inventories permit.

¹O’Neill, D G et al. “Epidemiology of Diabetes Mellitus among 193,435 Cats Attending Primary-Care Veterinary Practices in England.” Journal of veterinary internal medicine vol. 30,4 (2016): 964-72. doi:10.1111/jvim.14365

²Yoon, Samuel et al. “Epidemiological study of dogs with diabetes mellitus attending primary care veterinary clinics in Australia.” The Veterinary record vol. 187,3 (2020): e22. doi:10.1136/vr.105467

Hashtag: #petCGM #petdiabetes #vetmedicine #alrt

The issuer is solely responsible for the content of this announcement.

About ALR Technologies SG Ltd.

ALRT is a data management company that developed the ALRT Diabetes Solution, a comprehensive approach to diabetes care that includes an FDA-cleared and HIPAA compliant diabetes management system that collects data directly from blood glucose meters and continuous glucose monitoring devices, and a patent pending Predictive A1C algorithm to track treatment success between lab reports and an FDA-cleared Insulin Dosing Adjustment program. The overall goal is to optimize diabetes drug therapies to drive improved patient outcomes.

In addition, the animal health division of ALRT has developed the GluCurve Pet CGM; a solution to assist veterinarians better determine the efficacy of insulin treatments and to help to identify the appropriate dose and frequency of administration for companion animals, thereby delivering the same optimization of diabetic drug therapies to pets as to humans.

More information about ALRT can be found at www.alrt.com and https://sg.alrt.com.

ALR Technologies SG Ltd Forward-Looking Statement
This press release contains certain statements that are forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and that involve risks and uncertainties, including statements about our plan, objectives, expectations and intentions. Such statements are subject to numerous risks and uncertainties. Factors that could adversely affect our business and prospects are set forth in our public filings with the Securities and Exchange Commission. Our forward-looking statements are based on current beliefs and expectations of our management team and, except as required by law, we undertake no obligations to make any revisions to the forward-looking statements contained in this release or to update them to reflect events or circumstances occurring after the date of this release, whether as a result of new information, future developments or otherwise. Investors are cautioned not to place undue reliance on these forward-looking statements.

About Covetrus

Covetrus is a global animal-health technology and services company dedicated to empowering veterinary practice partners to drive improved health and financial outcomes. We are bringing together products, services, and technology into a single platform that connects our customers to the solutions and insights they need to work best. Our passion for the well-being of animals and those who care for them drives us to advance the world of veterinary medicine. Covetrus is headquartered in Portland, Maine with more than 5,700 employees serving over 100,000 veterinary customers around the globe. For more information about Covetrus, please visit https://covetrus.com/.

HONG KONG SAR – Media OutReach – 1 December 2022 – Research led by Hong Kong Baptist University (HKBU) involving the use of a pioneering female sterility technique has led to a breakthrough in the production of hybrid rice seeds. Compared to the commonly used “three-line” male sterility technique in hybrid rice seeds production, the novel approach enhances the efficiency of hybrid rice production by eliminating rice seeds that have been produced due to the self-pollination of the “restorer line”. The novel technique enables fully automatic harvesting of hybrid seeds by machines, which can substantially reduce harvesting costs.

The research results have recently been published in Cell Research, a top-ranking international scientific journal.

Male sterility technique incurs high harvesting costs

Self-pollinating plants are known to maintain their genome homozygosity, and as a result, their offspring can have the same features over generations.

Heterosis, which refers to the increased rate of growth due to genome heterozygosity as a result of the hybridisation of distant parents, is difficult to exploit with self-pollinating plants. In nature, rice is usually bred using self-pollination. However, over the past few decades, scientists – following pioneering work by Professor Yuan Longping, the “Father of Hybrid Rice” – have developed hybrid rice breeding techniques by exploiting sterile male genes, and these techniques can produce hybrid seeds with the normally self-pollinating rice plants in large quantities. China and other countries around the world have extensively used the male sterility technique to produce hybrid rice seeds, and it has led to a substantial increase in rice yields.

The male sterility technique first breeds cultivars, i.e. plant varieties, of the “male-sterile line” of rice as pollen receivers. Rice cultivars from the “restorer line” with normal fertility act as pollen donors, and they are grown close to the “male-sterile line” to facilitate pollen transfer for hybridisation. However, self-pollinating seeds can also be produced by the “restorer line”, and they must be removed manually to avoid mixing them up with the hybrid seeds before mechanical harvest, resulting in high harvesting costs. In theory, using sterile female rice as the “restorer line” is ideal because it cannot produce any self-pollinated seeds. However, this approach has not been adopted because the germplasm of sterile female rice remains extremely rare in nature and sterile female plants find it difficult to self-reproduce.

TFS1 mutation exhibits female sterility

After nearly a decade of ongoing study, a research team led by Professor Zhang Jianhua, Chair Professor of the Department of Biology at HKBU, has managed to identify a “spontaneous thermo-sensitive female sterility 1” (TFS1) gene mutation in an elite rice cultivar during paddy field production. This genetic mutation exhibits female sterility under regular or high temperature conditions (i.e. above 25°C), and fertility is partly resumed under low temperature conditions (i.e. 23°C). It does not have any defects in terms of its vegetative growth.

The team observed that rice with the TFS1 gene mutation can produce healthy pollen with normal male fertility. Rice with normal fertility can produce normal seeds after receiving pollen from rice with the TFS1 gene mutation. Further investigations revealed that under regular or high temperature conditions, after pollen has landed on the stigma of rice with the TFS1 gene mutation, pollen tubes that have grown from the pollen cannot enter the embryo sac. The embryos therefore fail to develop and seeds cannot be produced. But under low temperature conditions, the ability to fertilise and develop embryos is partially recovered.

Following genetic analysis using gene cloning and molecular techniques, the team found that the female sterility mutation is created by a point mutation in the genic region of Argonaute7 (AGO7), a member of the Argonaute (AGO) protein complex that is responsible for the production of many small interfering RNAs, namely tasiR-ARFs. The downstream regulation of these tasiR-ARFs regulates the pollen tube entrance into the embryo sac, but it failed under regular or high temperature conditions in the rice with TFS1 mutation, and hence double fertilisations cannot be achieved.

No need to remove “restorer lines” before harvest

To evaluate the potential of using TFS1 as a genetic tool for hybrid rice production, the team conducted field trials in Hong Kong and Hunan Province in mainland China. The TFS1 gene mutation was introduced into three cultivars of rice by introgression and genome editing to create the germplasms with thermo-sensitive female sterility. They acted as the “restorer lines” for pollen donation. Another three cultivars of rice with male sterility were used as the “male-sterile lines”.

The team planted the “restorer lines” separately next to the “male-sterile lines” as in traditional hybrid breeding, or randomly mixed them on the farm when planting. In both planting arrangements, more than 30% of the panicles of the “male-sterile lines” in Hong Kong, and 40% in Hunan Province produced hybrid seeds. The proportion of seed sets is similar to the hybrid production yields using existing “restorer lines”, but the hybrid rice seeds can be harvested without the removal of the “restorer lines”.

Great commercial potential with reduced harvesting costs

Professor Zhang said: “Nowadays, producing hybrid rice seeds is still a labour-intensive process in agriculture. Female sterility, if it can be introduced into a ‘restorer line’ as a pure pollen donor, has great potential to reduce the cost, because the male and female parents of hybrid rice can be grown and harvested together by machines without worrying about seed purity.

“Our research findings provide a suitable trait for fully mechanised hybrid rice breeding, and our genetic tool has shown great promise for commercial applications. To maximise rice yields, we need further large-scale field trials to improve the receptibility between female and male-sterile lines.”

Apart from researchers from HKBU, the research team included scientists from the Hunan Agricultural University, the Guangdong Academy of Agricultural Sciences, the University of California at Davis, and the National Agriculture and Food Research Organisation in Japan.

Hashtag: #HKBU

The issuer is solely responsible for the content of this announcement.

HONG KONG SAR – Media OutReach – 1 December 2022 – Asian global fashion icon, C-pop singer, film and television actress — Tia Lee’s (Lee Yu Fen) ingenious “GOODBYE PRINCESS” music video pre-release animation and fashion videography campaign hits record-breaking 100 million viewership within a month! The finale of “GOODBYE PRINCESS” animation series was released on 29 November. This marks the end of the series and signifies a new chapter for Tia. In addition, “GOODBYE PRINCESS” episodes finale gaining global attention, in anticipation of the official music video release on 5 Dec 2022.

The series’ finale, titled “The Beginning“, features the female lead, having returned to the depths of the water in the previous episode, watches the following scenes as silhouettes on the television set: just as the handsome prince tries to wake the princess with the kiss of life, she regains consciousness. With the signature look of determination in her eyes, she pushes the prince away. At this time, he reveals his true identity – a beastly creature, and tries to attack the princess. Meanwhile in the depths of the water, the television screen shatters as the beast reaches out his claws to attack the female lead. She quickly draws her memories from the television set, including images of the castle, the battle with the black pawns, the moments when she wore beautiful dresses and appears glamourous superficially, and the blood red water. These memories become a magical red rose, like a fairy’s wand. She picks it up and waves it to cast a spell, ultimately turning the beastly creature into a puppy. Holding her new pet in her armss with her back straight, she strides confidently towards the dazzling lights that she has always yearned for. This is the beginning of her new chapter.

“The Beginning” poster added on fuller details and path way for Tia’s new chapter in life:

1. In fairytales, the prince and beastly creatures are typically of good nature. The “GOODBYE PRINCESS” series has overturned this stereotype.
2. In the first episode, the television set leads the female character to travel through space and time. In the finale, she uses it to recall all kinds of memories that become the source of her strength for bravely facing the future.
3. The female lead character holds the puppy, strides towards a new path as they face upcoming challenges together. The puppy image is based on Tia’s actual pet dog, “Sun“, which is the only IG account the artist follows.

The final set of motion and still images for “The Beginning” was released today together with Vogue Hong Kong, showing Tia in all black Saint Laurent outfit and Christian Louboutin heels, a sharp contrast to the princessy look in the previous 5 episodes. Adding onto the determined look of Tia is a forward-looking glimpse towards the future.

The 6-part “GOODBYE PRINCESS” animation series was developed by an award-winning creative team based in Hong Kong, including Sunny Tang, Best Animation Award and Best Editing Award winner at Hong Kong Mobile Film Festival, illustrator Mandy Mackenzie Ng, scriptwriter Alex Lee, who have come together for the first time to work with Tia for this expressive series. Each 30-second episode has the spirit of a classic fictional “princess”, reconstructing age-old stories to tell a whimsical tale inspired by Tia’s own experience and journey in the entertainment industry. The series showcased Tia’s determination to break free, shake off biases that have been placed on her, paving the way forward to take ownership over her own destiny.

The series is a first-of-its-kind production that blends animation, music and real people to debut Tia’s renaissance. While Tia embraces a new chapter of her professional life, stay tuned for other new projects by Tia, which will be announced soon.

“GOODBYE PRINCESS” official music video release schedule:

Single Cover:	2 December
Official MV:	5 December

Official press materials:

“GOODBYE PRINCESS” Animation Episode 6:	https://youtu.be/g4GJgTIzo7U
“GOODBYE PRINCESS” Episode 6 Poster:	https://www.instagram.com/p/Clk3EB0PimY/ https://www.facebook.com/photo/?fbid=686169319542959&set=a.231904644969431 (for downloading)
“GOODBYE PRINCESS” Episode 6 Still Image:	https://www.instagram.com/p/ClndVULrIM0/ https://www.facebook.com/photo/?fbid=693311432162081&set=a.231904644969431 (for downloading)
“GOODBYE PRINCESS” Episode 6 Motion Image:	https://youtu.be/ZizEX3ev-sg
ROLLACOASTER UK Cover:	https://www.instagram.com/p/ClUA1Swtnyk/ https://www.facebook.com/photo/?fbid=688854202607804&set=a.231904644969431(for downloading)
Vogue Hong Kong「The Voice」Cover:	https://www.instagram.com/p/Ck7_neKsh_w/ https://www.facebook.com/photo/?fbid=681908259969065&set=pcb.681909583302266 (for downloading)

Tia Lee Official Channels:
Instagram @leeyufen: https://www.instagram.com/leeyufen/
YouTube: https://www.youtube.com/@tialeeofficial/
Facebook: https://www.facebook.com/leeyufentialee/
Weibo: https://weibo.com/u/1396928042/

Hashtag: #TiaLee

The issuer is solely responsible for the content of this announcement.

About Tia Lee | Lee Yu Fen:

Tia Lee Yu Fen (李毓芬), born in Taipei, is an Asian global C-pop singer, film and television actress, and model. In addition to her acting roles and musical career, Tia appears frequently at major fashion shows. As a fashion icon and trend-setter, Tia has graced the covers of fashion, beauty and lifestyle magazines such as Vogue, Elle, Marie Claire, and shares her beauty and fashion tips through a number of Vogue’s social media channels.

SINGAPORE – Media OutReach – 1 December 2022 – Award-winning Singapore telecommunications and managed security services provider ViewQwest and one of Vietnam’s fastest growing telecoms and technology solutions provider FPT Telecom International (FTI) have formed a strategic partnership to elevate their regional capabilities in providing ICT and digital transformation (DX) services to customers in the Asia Pacific (APAC) region, especially for large regional retailers. By combining ViewQwest’s extensive regional network and FTI’s one-stop digital solutions, the two companies are synergising their strengths to create win-win outcomes with customers.

Leveraging FTI’s competitive ICT and digital solutions capabilities, ViewQwest will work with FTI to further expand its Managed SASE and SDWAN service coverage. Both companies will be establishing colocation facilities in FTI’s data centre and provide on-ground technical and engineering support to ViewQwest’s customers in Vietnam and Singapore, including for software and hardware installation and troubleshooting services.

“Businesses globally are being swept up by the digital transformation wave, none more pronounced than in the retail sector especially enterprises with extensive multi-market coverage. Our partnership with FTI leverages their deep knowledge and experience in Vietnam and will enable us to better serve our customers with regional operations,” said Vignesa Moorthy, Chief Executive Officer of ViewQwest. “This combined play marks another milestone in our mission to help our customers build and transform their network and security architecture confidently, to streamline their operations and drive cost-savings, ultimately promoting business agility.”

“We would like to see continuation of our joint efforts to build a long-term and strategic partnership between ViewQwest and FTI. This collaboration comes at an important juncture, enabling us to further advance the potential of our complementary strengths to support customers. FTI is firmly committed to elevating our mutual efforts to deliver the best value to customers and we look forward to expanding our strategic engagement. We view our partnership as part of a package with significant long-term promise,” said Tran Hai Duong, Chairman of FTI. “I believe ViewQwest and FTI are fully ready to kick-start activities following the formalisation of our agreement, and I am keen to see its active implementation and the anticipated results of our partnership bearing fruit.”

Hashtag: #ViewQwest

The issuer is solely responsible for the content of this announcement.

About ViewQwest

ViewQwest is a leading regional provider of Managed Security and award-winning Connectivity services. Headquartered in Singapore and with operations in Malaysia, the Philippines, and Hong Kong, it is a trusted partner of global MNCs and top companies in North and Southeast Asia. As a certified Managed Security Services Provider with expertise in leading cybersecurity technologies, it helps build and manage high-performing network and security infrastructure for the digital enterprise, securely connecting corporate sites and workforces across the world.

ViewQwest also provides Premium Residential & Business broadband & cybersecurity services in Malaysia and Singapore, and has been consistently recognized as Singapore’s Fastest Fixed Network from 2018 to 2022 by Ookla Speedtest Awards.

About FPT Telecom International One Member Limited Company

Established on May 22, 2008, FPT Telecom International is a member company of FPT Telecom.

Inheriting the experience and infrastructure of the mother company – FPT Telecom, one of the leading telecommunication services providers in Vietnam, FPT Telecom International has been operating independently since the beginning of 2008 and is now considered to be one of the top reliable services providers in Vietnam.

FPT Telecom International is one of Vietnam’s most comprehensive and broadly adopted Cloud and IT services providers, offering a full spectrum of services nationwide.

Thousands of customers — including the fastest-growing startups, largest enterprises, and leading government agencies — use FPT Telecom International to optimize their costs, become more agile, and innovate faster.

We offer you the power and flexibility to choose the right IT infrastructure and level of managed services to compete more effectively and successfully grow your business.