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GOOLOO Expands National Retail Footprint, Launches Three Top-Selling Jump Starters in Walmart stores across the country

Brand’s largest brick-and-mortar expansion to date brings roadside emergency power off Amazon and onto Walmart shelves nationwide

SAN FRANCISCO, California, Aug. 4, 2026 /PRNewswire/ — GOOLOO, a global leader in portable power and roadside safety solutions, today announced the in-store launch of three of its best-selling jump starters — the GOOLOO A3X, GOOLOO G7X, and GOOLOO GE1500X — now available at approximately 4,000 Walmart stores across the United States. The rollout marks GOOLOO’s largest brick-and-mortar expansion to date, bringing the brand’s roadside emergency technology from online marketplaces directly to shoppers nationwide.

GOOLOO Expands National Retail Footprint, Launches Three Top-Selling Jump Starters in Walmart stores across the country
GOOLOO Expands National Retail Footprint, Launches Three Top-Selling Jump Starters in Walmart stores across the country

“Nearly half of the more than 32 million roadside assistance calls AAA receives each year involve dead batteries, flat tires, or lockouts. We wanted these three jump starters within arm’s reach of shoppers, not a shipping label away,” said Michael, General Manager at GOOLOO.

Until now, GOOLOO’s jump starters have been sold primarily through e-commerce channels. Their arrival at Walmart gives U.S. drivers same-day access to emergency power products, addressing a common frustration among customers who need battery assistance immediately rather than waiting on shipping.

The three products now available at Walmart include:

GOOLOO A3X 3000A Jump Starter with Air Compressor 

Designed as an all-in-one roadside solution, the A3X combines emergency jump-starting capability with a built-in tire inflator, helping drivers handle two of the most common roadside situations: dead batteries and low tire pressure.

Featuring automatic shut-off inflation, emergency lighting, USB power functionality, and GOOLOO’s SUPERSAFE™ protection system with multiple layers of battery safety protection, the A3X provides drivers with confidence and convenience in one compact device.

GOOLOO G7X 3000A Jump Starter 

The G7X introduces a new approach to everyday jump starter design by combining emergency starting capability with portable charging convenience.

Its integrated USB-C 45W fast-charging cable serves as both a built-in charging solution and a compact carry design feature, allowing users to charge smartphones, including the latest USB-C devices, and select laptops.

By increasing everyday usability beyond emergency situations, the G7X transforms the traditional jump starter from a product stored away for occasional emergencies into a practical portable power companion.

GOOLOO GE1500X 1500A Jump Starter

Designed for everyday drivers, the GE1500X delivers reliable emergency starting power with a compact and easy-to-use design.

Featuring emergency lighting, USB power functionality, and advanced safety protections, the GE1500X provides dependable roadside support for daily driving needs.

The GE1500X offers 1500A peak current for vehicles up to 6.0L gas or 4.0L diesel engines, a 400-lumen emergency flashlight with SOS mode, and UL 2743 / c-TUV-us certified safety protections.

All three jump starters are available now at Walmart stores nationwide and on Walmart.com, in addition to GOOLOO’s existing online retail channels.

About GOOLOO

GOOLOO is a leading global automotive roadside safety ecosystem brand specializing in high-performance lithium-ion portable jump starters, tire inflators, and multi-functional emergency tools. With its patented technologies SUPERSAFE®, JUMPCORE™ and TOOLCORE™, it has been serving millions of customers and drivers for over 12 years.

 

KPJ Healthcare Launches First Orthopaedic and Rheumatology Centre of Excellence Under the KPJ Health System

BUKIT MERTAJAM, Malaysia, Aug. 3, 2026 /PRNewswire/ — KPJ Healthcare Berhad (“KPJ Healthcare” or “the Group”) today launched its first Orthopaedic and Rheumatology Centre of Excellence (“CoE”) at KPJ Penang Specialist Hospital (“KPJ Penang”), marking the third CoE under the KPJ Health System (“KPJHS”). As Malaysia’s first private integrated academic health system, the Group continues to advance specialised musculoskeletal and joint care through the integration of Practice, Education, Research and Innovation.

YBhg. Datuk Syed Mohamed Syed Ibrahim, Chairman of the KPJ Health System Governing Council, Chairman of KPJ Healthcare University Sdn. Bhd. and President & Chief Executive of Johor Corporation (seated, centre), together with KPJ Healthcare Berhad’s Board of Directors and senior management team as well as KPJ Penang Specialist Hospital’s Consultant Team at the launch of the hospital’s Orthopaedic & Rheumatology Centre of Excellence.
YBhg. Datuk Syed Mohamed Syed Ibrahim, Chairman of the KPJ Health System Governing Council, Chairman of KPJ Healthcare University Sdn. Bhd. and President & Chief Executive of Johor Corporation (seated, centre), together with KPJ Healthcare Berhad’s Board of Directors and senior management team as well as KPJ Penang Specialist Hospital’s Consultant Team at the launch of the hospital’s Orthopaedic & Rheumatology Centre of Excellence.

Designed to support the management of complex conditions, the Orthopaedic and Rheumatology CoE integrates orthopaedic subspecialties, rheumatology and multidisciplinary expertise such as rehabilitation within a coordinated model of care. Bringing together consultations, diagnostic imaging, treatment rooms and advanced rehabilitation together on a single floor, the Centre provides a more seamless patient experience from diagnosis through rehabilitation and recovery. Comprehensive services include general orthopaedics, spine surgery, arthroplasty (joint replacement), arthroscopy and sports surgery, foot and ankle surgery, hand and microsurgery, paediatric orthopaedics, trauma and fracture management, rheumatology and pain services.

Its capabilities are further enhanced by AI-assisted robotic joint replacement surgery, computer-assisted navigation and minimally invasive surgical techniques, supporting greater surgical precision, improved mobility and faster functional recovery. Supporting these capabilities are tailored rehabilitation programmes, including post-spine surgery, post-sports injury and paediatric orthopaedic rehabilitation, supported by specialised technologies such as an anti-gravity treadmill.

YBhg. Datuk Syed Mohamed Syed Ibrahim, Chairman of the KPJHS Governing Council, Chairman of KPJ Healthcare University Sdn. Bhd. and President & Chief Executive of Johor Corporation (“JCorp”) said, “Our ambition for every Centre of Excellence in the KPJ Health System, including the one we launch today, is not that it should remain a Centre in perpetuity. Our ambition is for it to continue growing, strengthening its clinical, academic and research capabilities until, over time, it is elevated into an Institute: a destination in its clinical discipline, a generator of published evidence, a trainer of national and international leaders, and a partner sought after by industry, academia and governments. World-class in the fullest meaning of that phrase.”

The Orthopaedic and Rheumatology CoE builds on the establishment of the Heart & Lung Centre of Excellence at Johor Specialist Hospital and the Neuroscience & Stroke Centre of Excellence at Damansara Specialist Hospital 2, reinforcing KPJ Healthcare’s long-term strategy to establish 15 Centres of Excellence nationwide by 2030 under the KPJHS. Through its integrated hub model anchored by KPJ Penang Specialist Hospital together with KPJ Selangor Specialist Hospital, the Centre enables shared expertise, common clinical standards, coordinated research and multidisciplinary collaboration across the KPJ Health System, demonstrating how specialised care can be delivered through one integrated academic health system. This integrated approach also provides the platform to accelerate the convergence of artificial intelligence, genomics and value-based care in shaping the future of specialised healthcare delivery.

KPJ Penang is a 270-bed tertiary hospital supported by more than 50 resident consultants across over 20 medical specialties. The establishment of the Orthopaedic and Rheumatology CoE further strengthens the hospital’s role within the KPJHS. Through the Centre, patients benefit from greater access to advanced orthopaedic treatments that have demonstrated improved patient-reported outcomes and shorter hospital stays. Complementing these capabilities, KPJ Penang is also the first in the Northern Region to provide advanced wound care management and, in collaboration with KPJ Healthcare University, is developing Malaysia’s first AI-assisted remote telewound care programme.

ENDS

About KPJ Healthcare Berhad 

KPJ Healthcare operates 30 hospitals across Malaysia and four Ambulatory Care Centres, serving 3.3 million patients annually with 1,491 medical consultants. Nineteen hospitals are accredited by MSQH and four by JCI. As Malaysia’s first private healthcare provider to establish an Academic Health System, KPJHS integrates practice, education and research & innovation to drive clinical excellence and patient experience. Beyond hospitals, KPJ Healthcare operates Klinik Waqaf An-Nur (KWAN) clinics, dialysis centres and mobile clinics nationwide, and offers more than 40 academic programmes at KPJ Healthcare University (KPJU). KPJ Healthcare has been a constituent of the Bursa Malaysia FTSE4Good Index since 2016.

Thailand – Canada Pilot Carbon Capture in Cement Industry to Advance Net Zero 2050


BANGKOK, THAILAND – Media OutReach Newswire – 3 August 2026 – Thai Cement Manufacturers Association (TCMA) is advancing Thailand–Canada collaboration by piloting carbon capture technology in the Thai cement industry. The initiative designates the “Saraburi Sandbox” as a low-carbon technology testbed, bringing together industry, government, academia, and global partners to support the transition to a low-carbon economy, while enhancing the long-term competitiveness of Thailand’s industrial sector.

นางสาวริเชลล์ บูร์กวง ปลัดกระทรวงการค้าและกา.jpeg

From Thailand–Canada Collaboration to Industrial-Scale Deployment

TCMA announced progress in its strategic Thailand–Canada partnership under the project “Decarbonization of the Cement and Concrete Sectors in Thailand.” As part of the initiative, a Mobile Carbon Capture Unit (MCCU) has been deployed in Thailand for the first time to test the technology’s performance in real industrial conditions within the cement sector.

The deployment of the MCCU marks a significant step in strengthening technological readiness for carbon capture—one of the key solutions for high-emission industries such as cement—while supporting the Thailand 2050 Net Zero Cement and Concrete Roadmap.

Dr. Chana Poomee, Honourary Chairman of TCMA and President of the ASEAN Federation of Cement Manufacturers (AFCM), stated that the project reflects Thailand’s strong commitment to driving industry toward Net Zero through international collaboration. TCMA serves as a central platform linking industry, government, academia, and global organizations to develop practical carbon reduction solutions.

“The transition to Net Zero for hard-to-abate sectors such as cement cannot be achieved in isolation. It requires policy support from the government, as well as international collaboration in technology, finance, and knowledge transfer to accelerate real-world implementation,” Dr. Chana said.

Connecting Technology and Investment Through Global Collaboration

The project is funded by the Government of Canada through Environment and Climate Change Canada (ECCC), with the United Nations Industrial Development Organization (UNIDO) serving as the implementing agency. The initiative aims to develop a technology and innovation ecosystem for decarbonizing Thailand’s cement and concrete industries.

Ms. Richelle Bourgouin, Deputy Minister of Trade and Export Development, Saskatchewan, Canada, noted that the collaboration highlights the power of integrating knowledge, technology, and innovation to support the transition toward a low-carbon economy.

“This partnership also opens opportunities to connect expertise in clean technology, research, and innovation between the two countries, enabling the development of practical solutions and fostering future trade and investment cooperation in Thailand and across ASEAN,” Ms. Richelle said.

A key outcome of the project is the deployment of the MCCU, developed by the Clean Energy Technologies Research Institute (CETRI) at the University of Regina, Canada. The unit will be tested in Thailand to evaluate its performance and applicability within the Thai cement industry.

“Saraburi Sandbox”: A PPP Model for Accelerating Low-Carbon Industry

Under the project, TCMA is collaborating with Chulalongkorn University to study and transfer knowledge on carbon capture technology while building human capacity. The MCCU will be rotated across cement plants operated by TCMA member companies in Saraburi province to test performance, collect technical data, and assess future investment pathways.

The “Saraburi Sandbox” serves as a Public-Private Partnership (PPP) platform, bringing together government, industry, academia, and international partners to pilot and scale carbon reduction technologies, while establishing investment models for a low-carbon economy.

The area is being developed as a prototype low-carbon city, integrating technology, infrastructure, standards, and investment frameworks to support Thailand’s long-term industrial transition.

Accelerating Readiness for a Low-Carbon Future

Dr. Chana emphasized that deploying the MCCU in Thailand represents an important step in enhancing technological and knowledge readiness, particularly in carbon capture technologies that are essential for industries facing significant decarbonization challenges.

Preparation must begin today, as the transition to Net Zero requires time for technological development, workforce readiness, and infrastructure buildout, alongside appropriate support mechanisms. This is especially important as global carbon measures—such as carbon pricing and emissions trading systems (ETS)—become increasingly stringent.

“The success of decarbonizing the cement industry depends on collaboration across all sectors to create an enabling ecosystem for investment and to accelerate the adoption of technologies at scale,” Dr. Chana said.

TCMA’s efforts not only reflect the Thai cement industry’s commitment to translating decarbonization plans into action, but also reinforce the importance of Thailand–Canada collaboration in advancing clean technologies and innovation in the industrial sector. This includes knowledge transfer, technology development, and expanding future investment partnerships.

This collaboration represents a key mechanism in laying the foundation for Thailand’s cement industry to remain competitive in a low-carbon economy, while accelerating progress toward Net Zero 2050 and strengthening Thailand’s role as a regional model for low-carbon industrial development in ASEAN.

Hashtag: #TCMA #สมาคมอุตสาหกรรมปูนซีเมนต์ไทย #CementActionToNetZero #CarbonCapture #MCCU #NetZero2050 #ไทยแคนาดา #ClimateTech #สระบุรีแซนด์บ็อกซ์

The issuer is solely responsible for the content of this announcement.

Hualien Summer Fun ONE PIECE: Every Stop is a Unique Hualien Adventure

HUALIEN, Aug. 3, 2026 /PRNewswire/ — For the first time ever, the Hualien County Government has launched a crossover collaboration with the globally ultra-popular IP, ONE PIECE! The massive 15-meter-long Thousand Sunny has officially set sail for Liyu Lake in Shoufeng Township, becoming the biggest highlight of the event. Making a simultaneous debut are six all-new classic character installations, which are placed in combination with Hualien’s diverse local features:

  • Usopp at Hualien Railway Station, echoing the imagery of a new adventure setting off.
  • Zoro at the century-old General’s House (Chiang Chün Fu). Fusing Japanese architecture with cultural heritage, the site echoes the perseverance and conviction represented by Zoro.
  • Luffy at the bustling Dongdamen Night Market. Gathering Hualien’s local delicacies, it is a crucial hub for travelers to experience local flavors—something the food-loving Luffy could never miss.
  • Sanji at Sunrise Square. Boasting views of Hualien Fishing Harbor, it presents a rich marine culture and fresh ingredients, echoing Sanji’s vitality and passion.
  • Nami at Zhikaxuan Forest Park. Surrounded by lush greenery and ecological landscapes, the park provides a space for families to relax and experience nature.
  • Chopper at the event’s main venue, Liyu Lake in Shoufeng Township. Famous for its stunning lake and mountain scenery, the area offers a tourism atmosphere that is both for sightseeing and therapeutic healing, perfectly echoing Chopper’s character traits!

The Hualien County Government stated that the event will run until August 20. In addition to a stamp rally mission, the nighttime will feature spectacular water and light shows, starry sky fireworks displays, and world-class fire dance performances!

Information provided by the Hualien County Government
Information provided by the Hualien County Government

 

iRad Hospital Featured on CNN’s Meanwhile in Asia

Spotlighting Macao’s Emerging Medical and Wellness Sector


MACAU SAR – Media OutReach Newswire – 3 August 2026 – iRad Hospital, a premier medical and wellness facility launched by Melco Resorts & Entertainment and iRad Group, was recently featured in a July 2026 episode of CNN’s internationally broadcast program Meanwhile in Asia. The program discussed Macao’s efforts to diversify its economy beyond gaming, spotlighting its medical and wellness tourism sector.

iRad Hospital at Studio City, Macau
iRad Hospital at Studio City, Macau

During the episode, CNN examined how destinations across Asia are seeking new growth avenues, noting Macao’s strategic push to develop a niche in medical tourism. The feature included a visit to iRad Hospital, which opened within a luxury integrated resort environment, and highlighted its proposition of allowing visitors to incorporate health screenings and aesthetic treatments into their leisure or family stays.

Located at Melco’s Studio City, iRad Hospital is the world’s first and Macao’s only integrated resort hospital. In partnership with iRad, Melco is playing a leading role in advancing Macao’s medical tourism development by integrating healthcare and wellness services with its world-class Forbes Five-star spa portfolio. The initiative aligns with Macao’s broader economic diversification objectives and contributes to strengthening the city’s appeal to high-value international visitors beyond gaming.

iRad Hospital offers advanced diagnostic imaging, wellness and preventive care, aesthetic medicine, executive health screening, and dedicated medical concierge services. Through partnerships with leading hospitals and institutions in Hong Kong, the United States and Korea, the hospital provides visitors with access to expanded specialty medical resources and healthcare options.

Mr. Lawrence Ho, Chairman & CEO of Melco Resorts & Entertainment, said, “Macao’s next phase of development will be defined by quality, innovation, and diversification. As the leading integrated resort operator, we are committed to advancing the evolution of the integrated resort model beyond traditional hospitality—integrating culture, wellness, and high‑value services that strengthen the city’s long‑term competitiveness. Through initiatives such as iRad Hospital at Studio City, Melco is helping shape the development of integrated medical and wellness tourism and enhancing Macao’s visibility as a diversified international destination.”

Hashtag: #melco #iRadHospital #iRad #StudioCity #medicaltourism #wellness





Wechat: 新濠博亚娱乐

The issuer is solely responsible for the content of this announcement.

About Melco Resorts & Entertainment Limited

The Company, with its American depositary shares listed on the Nasdaq Global Select Market (Nasdaq: MLCO), is a developer, owner and operator of integrated resort facilities in Asia and Europe. The Company currently operates City of Dreams () and Altira Macau (), integrated resorts located in Cotai and Taipa, Macau, respectively. In addition, the Company operates Studio City (), a cinematically-themed integrated resort in Cotai, Macau. In the Philippines, the Company operates and manages City of Dreams Manila (), an integrated resort in the Entertainment City complex in Manila. In Europe, the Company operates City of Dreams Mediterranean, an integrated resort in Limassol, in the Republic of Cyprus (). In South Asia, the Company manages the Nüwa hotel at City of Dreams Sri Lanka (), an integrated resort in Colombo, Sri Lanka. For more information about the Company, please visit.

The Company is majority owned by Melco International Development Limited, a company listed on the Main Board of The Stock Exchange of Hong Kong Limited, which is in turn majority owned and led by Mr. Lawrence Ho, who is the Chairman, Executive Director and Chief Executive Officer of the Company.

About iRad – Hong Kong’s largest MRI diagnostic services provider

Established in 2006, iRad is a trusted leader in diagnostic radiology across Hong Kong. As at 2024, iRad was the largest MRI diagnostic services provider in Hong Kong by revenue and by the number of MRI scanners. Focused on delivering high-quality imaging services and exceptional patient care, the Group’s strong and extensive client base includes the Government of the Hong Kong SAR, as well as other high-profile medical groups, corporations, private doctors and NGOs. Meanwhile, iRad Hospital is the first and largest private medical imaging and examination service provider within an integrated resort in Macau, making iRad Group the first medical imaging group in the world to offer comprehensive private imaging and examination services, including MRI and CT services, to the integrated resort industry.

Ascletis Announces Initiation of Global Phase III for Oral Small Molecule GLP-1, ASC30 and Positive Preclinical Data for Its First-in-Class Oral Small Molecule GLP-1/GIP/Amylin Fixed-Dose Combination

-Initiated global Phase III program for oral small molecule GLP-1, ASC30, which will enroll approximately 4,600 participants with obesity or overweight across two pivotal trials in the U.S., Europe, and Canada.

-Positive preclinical data in non-human primates announced for first-in-class once-daily oral small molecule GLP-1/GIP/amylin fixed-dose combination.

-Industry leading one-pill once-daily oral small molecule portfolio for obesity and other metabolic diseases: five programs spanning GLP-1, GIP, and amylin targets, alone and in fixed-dose combinations.

-Sufficient cash on hand to support operations into 2029, beyond the expected submission of a New Drug Application (NDA) in the U.S. by the end of 2028 and a Marketing Authorisation Application (MAA) in Europe in early 2029 for ASC30.

HONG KONG, Aug. 3, 2026 /PRNewswire/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces once-daily oral small molecule GLP-1 (ASC30) has received Phase III clearance from the U.S. Food and Drug Administration (FDA). ASC30 is the primary pillar of Ascletis’ oral small molecule obesity portfolio. The Company has initiated a global Phase III program for ASC30 chronic weight management indication consisting of two pivotal global Phase III, multicenter, randomized, double-blind, placebo-controlled trials (AURORA-1 NCT07743463 and AURORA-2 NCT07743450) in a total of approximately 4,600 participants with obesity or overweight in the U.S., Europe, and Canada. The two pivotal studies will investigate the long-term efficacy, safety, and tolerability of three maintenance doses (20 mg, 40 mg and 60 mg) of once-daily oral ASC30 compared with placebo in participants with obesity or overweight without type 2 diabetes (AURORA-1) and in participants with obesity or overweight with type 2 diabetes (AURORA-2). The treatment duration of both AURORA-1 and AURORA-2 are 72 weeks, with titrations of 12 weeks, 16 weeks and 20 weeks for 20 mg, 40 mg and 60 mg maintenance dose cohorts, respectively. The Company expects to announce topline data from the ASC30 Phase III program in the third quarter of 2028, with a U.S. FDA New Drug Application (NDA) filing expected by the end of 2028 and a European Medicines Agency (EMA) Marketing Authorisation Application (MAA) filing expected in early 2029. If approved by the respective regulatory authorities in the U.S. and Europe, this will make ASC30 potentially the second oral small molecule GLP-1 approved in the U.S. and Europe after orforglipron. The Company has sufficient cash on hand to support operations into 2029, beyond the expected submission of an NDA and an MAA for ASC30.

Ascletis also announces positive data for its first-in-class once-daily oral small molecule GLP-1/GIP/amylin triple agonist fixed-dose combination (FDC). The addition of this triple agonist FDC gives Ascletis a highly comprehensive and advanced oral small molecule portfolio for the treatment of obesity and other metabolic diseases (Table 1). The portfolio includes a best-in-class Phase III once-daily oral small molecule GLP-1, a first-in-class once-daily oral small molecule GLP-1/GIP dual agonist FDC (the first tirzepatide-like oral small molecule combination), a first-in-class once-daily oral small molecule GLP-1/GIP/amylin triple agonist FDC (the first oral tirzepatide+eloralintide-like small molecule combination), and a first-in-class once-daily oral small molecule eloralintide-like selective amylin receptor agonist (SARA). This comprehensive portfolio places Ascletis in a unique competitive position to significantly expand the population that can be treated with oral agents.

Table 1. Ascletis Once-Daily Oral Small Molecule Portfolio

Target

Drug Candidate

Development Status

GLP-1R

ASC30

Phase III

GLP-1R/GIPR

ASC30_48FDC

IND Filing 4Q2026

GLP-1R/GIPR/amylin receptor
(SARA)

ASC30_48_39FDC

IND Filing 4Q2026

Amylin receptor (SARA)

ASC39

IND Filing 3Q2026

GLP-1R/amylin receptor (SARA)

ASC30_39FDC

IND Filing 3Q2026

Notes: FDC: fixed-dose combination; SARA: selective amylin receptor agonist.

Oral Small Molecule Triple Agonist Combination (GLP-1/GIP/Amylin)

Ascletis’ first-in-class once-daily oral small molecule triple agonist FDC targeting GLP-1, GIP, and amylin (SARA) (ASC30_48_39FDC) demonstrated a GIPR agonist (ASC48) dose-dependent, statistically significant body weight reduction of up to 15.2% in non-human primates (NHPs) after seven-day treatment. This represents an up to 120% greater relative body weight reduction compared to oral dual agonist FDC targeting GLP-1R and amylin receptor (SARA) (ASC30_39FDC) (Table 2). The data suggest that GIP component (ASC48) is critical to ASC30_48_39FDC triple agonist. ASC30_48_39FDC is the oral small molecule triple agonist equivalent to injectable triple agonist peptides like tirzepatide+eloralintide which demonstrated a 29% reduction in body weight in humans at week 32 in a recently disclosed study [1].

Table 2. Once-Daily Oral Administration of ASC30_48_39FDC for Seven Consecutive Days in Non-Human Primates (NHPs)

Group

Dosing

Total body weight change
from baseline

ASC30_39FDC

(GLP-1R/amylin receptor
(SARA))

2 mg/kg ASC30

and 0.1 mg/kg ASC39

PO, QD

-6.9 %

ASC30_48_39FDC

(GLP-1R/GIPR/amylin
receptor (SARA))

2 mg/kg ASC30,

1 mg/kg ASC48,

and 0.1 mg/kg ASC39

PO, QD

-12.1%

(p < 0.05 vs ASC30_39FDC)

2 mg/kg ASC30,

2 mg/kg ASC48,

and 0.1 mg/kg ASC39

PO, QD

-15.2%

(p < 0.01 vs ASC30_39FDC)

Notes: FDC: fixed-dose combination; SARA: selective amylin receptor agonist; PO: oral administration; QD: once daily.

Oral Small Molecule Eloralintide-like SARA

Ascletis’ first-in-class once-daily oral small molecule eloralintide-like SARA (ASC39) is the second pillar of Ascletis oral small molecule obesity portfolio. ASC39 demonstrated eloralintide-like amylin selectivity and efficacy in preclinical models (Press Release). ASC39 was 40-fold more selective for human amylin 1 receptor (hAMY1R) over human calcitonin receptor (hCTR), which is comparable to the 60-fold greater selectivity of eloralintide in the same preclinical model. Once-daily oral administration of 5 mg/kg ASC39 for six consecutive days in the diet-induced obese rats produced a weight loss of 6.0%, similar to eloralintide at 5.0% (Table 3). ASC30_39FDC, a GLP-1/amylin dual agonist FDC, is expected to be the first FDC of this type to enter the clinic in the fourth quarter of 2026.

Table 3. Once-Daily Oral Administration of ASC39 for Six Consecutive Days Compared to Eloralintide SQ in Obese Rats

Group

Dosing

Total body weight change from baseline

Obese rats treated with eloralintide

3 nmol/kg,

SQ, Q3D

-5.0 %

Obese rats treated with ASC39
(amylin receptor (SARA))

5 mg/kg,
PO, QD

-6.0 %

Notes: Obese rats: diet-induced obese rats; SQ: subcutaneous; Q3D: once every 3 days; PO: oral administration; QD: once daily.

Oral Small Molecule Dual Agonist Combination (GLP-1/GIP)

Ascletis’ first-in-class once-daily oral dual FDC targeting GLP-1R and GIPR (ASC30_48FDC) demonstrated a 10.5% body weight reduction in non-human primates after eight-day treatment. This represents a 52% greater relative body weight reduction compared to ASC30 monotherapy (Press Release). ASC48, a first-in-class oral small molecule GIPR agonist, in a head-to-head in vitro study versus tirzepatide, demonstrated an EC50 of 1 pM in the hGIPR cyclic adenosine monophosphate (cAMP) activation assay, exhibiting greater potency than tirzepatide (EC50 = 3 pM). ASC30_48FDC represents the oral small molecule dual agonist equivalent to injectable dual agonist peptides like tirzepatide. Tirzepatide demonstrated up to a 20.9% reduction in body weight in humans as reported in the tirzepatide package insert[2].

Table 4. Once-Daily Oral Administration of ASC30_48FDC for Eight Consecutive Days in Non-Human Primates (NHPs)

Group

Dosing

Total body weight change from
baseline

ASC30 (GLP-1R)

2 mg/kg

PO, QD

-6.9 %

ASC30_48FDC

(GLP-1R/GIPR)

2 mg/kg ASC30 and

5 mg/kg ASC48

PO, QD

-10.5 %

Notes: FDC: fixed-dose combination; PO: oral administration; QD: once daily.

“Following recent positive end-of-Phase II feedback received from the FDA for ASC30, we are excited to have initiated the global Phase III program of ASC30, the primary pillar of our one-pill once-daily oral small molecule obesity portfolio.” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis. “ASC30 (GLP-1), ASC48 (GIP) and ASC39 (amylin SARA) are small molecules with different physical-chemical properties. We have overcome multiple challenges during the development of fixed-dose combinations of these molecules. The new data for our first-in-class oral small molecule triple agonist fixed-dose combination (GLP-1/GIP/amylin) reinforces our industry-leading, comprehensive and differentiated portfolio of one-pill once-daily oral small molecules for the treatment of obesity and other metabolic diseases.”

[1] Eli Lilly and Company. Safety, tolerability, pharmacokinetics and pharmacodynamics of eloralintide and tirzepatide co-administered as once-weekly subcutaneous injections [Abstract accepted for presentation at EASD 2026]

[2] ZEPBOUND (tirzepatide) injection, for subcutaneous use [US Prescribing Information]. Indianapolis, IN: Eli Lilly and Company. Section 14.1, Table 2 (Changes in Body Weight at Week 72 in Study 1)

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potentially best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a once-daily oral small molecule GLP-1R agonist for chronic weight management and diabetes; ASC30_48 FDC, a once-daily oral small molecule dual agonist, a fixed dose combination of ASC30 (GLP-1R agonist) and ASC48 (GIPR agonist), ASC30_48_39 FDC, a once-daily oral small molecule triple agonist, a fixed dose combination of ASC30 (GLP-1R agonist), ASC48 (GIPR agonist) and ASC39 (amylin receptor agonist (SARA)), ASC39, an eloralintide-like potent selective amylin receptor agonist (SARA) once-daily small molecule, ASC30_39 FDC, a once-daily oral small molecule dual agonist, a fixed dose combination of ASC30 (GLP-1R agonist) and ASC39 (amylin receptor agonist (SARA)), ASC36, an amylin peptide, designed to be administered once monthly to once quarterly subcutaneously and once daily orally, ASC35, a once-monthly subcutaneously administered GLP-1R/GIPR dual peptide agonist, ASC36_35 FDC, a once-monthly subcutaneous triple peptide agonist, a fixed combination of ASC36 (amylin receptor agonist) and ASC35 (GLP-1R/GIPR agonist), ASC37, a GLP-1R/GIPR/GCGR triple peptide agonist, designed to be administered once monthly subcutaneously and once daily orally, and ASC36_37 FDC, a once-monthly subcutaneous quadruple peptide agonist, a fixed dose combination of ASC36 (amylin receptor agonist) and ASC37 (GLP-1R/GIPR/GCGR agonist), for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

For more information, please visit www.ascletis.com

Contact:
Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com 

Ascletis Pharma Inc. PR and IR Teams
+86-181-0650-9129 (China)
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WATERBOMB SEOUL 2026 Successfully Concludes as CSTS and PremierX™ Help Power the Festival’s Global Future

SEOUL, South Korea, Aug. 3, 2026 /PRNewswire/ — WATERBOMB SEOUL 2026 successfully concluded an unforgettable three-day celebration of music, entertainment and immersive fan experiences, bringing together tens of thousands of fans from Korea and around the world for one of Asia’s most anticipated summer festivals. Held at the KINTEX Outdoor Global Stage in Goyang, the event showcased the unique combination of live music and signature water-themed attractions that have made Waterbomb a global cultural phenomenon.

Credit: Waterbomb
Credit: Waterbomb

Fans experienced a diverse lineup of some of the biggest names in K-pop, hip-hop and electronic dance music with performances by global and regional stars including Jay Park, ZICO, KARINA, Taemin, Sunmi, and Shownu & Hyungwon of MONSTA X, among others.

Widely regarded as Korea’s premier water-themed music festival, Waterbomb once again delivered its signature blend of music, energy and audience participation. Beyond the performances, attendees took part in large-scale water battles and immersive interactive experiences that have become synonymous with the festival. Its unique format continues to distinguish it from other music events, creating an environment where audiences are participants rather than simply spectators.

The Seoul 2026 edition also marked a significant milestone for CSTS Enterprises and its PremierX brand, whose involvement reflects CSTS Group’s growing commitment to experiential live entertainment. Earlier this year, CSTS announced its strategic collaboration with MADEONE Corp., owner and operator of Waterbomb, to support continued development of the festival in Seoul and around its international expansion.

Through the partnership, CSTS and PremierX contributed their expertise in hospitality, entertainment strategy, audience engagement and brand development, helping reinforce Waterbomb’s position as one of the most influential festival properties from Asia. The successful execution of Waterbomb Seoul 2026 further demonstrates the strength of the partnership and the growing international appeal of the Waterbomb brand.

“Waterbomb is much more than a music festival. It is a global lifestyle and cultural platform that connects audiences through unforgettable experiences,” said Winnie Chan, General Manager, CSTS Integrated Marketing. “The success of Waterbomb Seoul 2026 highlights the power of collaboration between CSTS, PremierX and MADEONE, and reinforces our shared vision of bringing this iconic entertainment experience to audiences around the world.”

As the final water cannons fired and performances concluded, Waterbomb Seoul 2026 closed another landmark chapter in the festival’s history, setting the stage for continued international growth. Building on this momentum, CSTS and PremierX look forward to supporting the next phase of Waterbomb’s expansion, bringing the festival’s unique blend of music, community and immersive entertainment to new audiences across Asia and beyond.

Credit: Waterbomb
Credit: Waterbomb

About WATERBOMB

WATERBOMB is South Korea’s globally recognized water-themed music festival, combining performances from leading K-pop, hip-hop and EDM artists with large-scale interactive water experiences. Since its launch in 2015, the festival has expanded beyond Korea to become one of Asia’s most recognizable live entertainment brands.

About CSTS Enterprises

CSTS Enterprises is an integrated media, entertainment, sports, and travel technology group. The company develops and partners with intellectual properties and brands to deliver compelling experiences that connect with local and regional audiences across the world. In addition to its own initiatives, including Generation C and PremierX, it collaborates with international IPs such as the FIFA World Cup, Formula 1, and Waterbomb.

CSTS integrates experiential marketing, tourism, data, and technology to deliver connected audience experiences. The company engages consumers across physical events and digital channels, working with clients to execute at scale across markets, turning complex activations into co-ordinated, measurable outcomes.

About MADEONE Corp.

MADEONE Corp. is a Seoul-based creative production house and entertainment agency specializing in the development and execution of leading festival experiences. Guided by the philosophy, “If our hearts don’t beat, we cannot thrill anyone,” MADEONE has redefined the music festival landscape through its flagship brand, WATERBOMB®, integrating music, performance, and audience participation into a new entertainment paradigm. In addition to festival production, the company provides theatrical services and manages talent in the arts and entertainment. MADEONE continues to expand its global footprint through international editions of its high-energy events.


AutoFlight Showcases Advanced Air Mobility During Games of the Future 2026 in Astana, Kazakhstan

  • AutoFlight completes first Air Taxi Demonstration Flight in Astana
  • Advanced Air Mobility showcased during Games of the Future 2026
  • Partnership with AAAG supports commercial deployment in Kazakhstan

ASTANA, Kazakhstan, Aug. 3, 2026 /PRNewswire/ — AutoFlight, a global leader in Advanced Air Mobility (AAM), together with its strategic partner Alatau Advance Air Group Ltd. (AAAG), is showcasing Advanced Air Mobility through live electric vertical takeoff and landing (eVTOL) demonstration flights and themed activities during the Games of the Future 2026 in Astana, Kazakhstan. https://www.linkedin.com/feed/update/urn:li:activity:7486683825448787968


AutoFlight Showcases Advanced Air Mobility During Games of the Future 2026 in Astana, Kazakhstan

AutoFlight successfully completed its Air Taxi Demonstration Flight on 24 July, with the ton-class eVTOL aircraft continuing to be showcased throughout the Games of the Future 2026 as part of the official public exhibition. https://www.youtube.com/watch?v=jxQ2uT9v3h0

As one of the world’s leading international phygital tournaments, Games of the Future 2026 brings together more than 800 competitors from over 50 countries across eight disciplines, combining elite physical competition with digital gaming. Against this global stage, AutoFlight’s showcase demonstrates how Advanced Air Mobility is becoming part of the future of transportation.

The Astana demonstration follows AutoFlight’s successful first eVTOL flight in Alatau City in May 2026 and reflects the company’s continued commitment to supporting the development of Advanced Air Mobility in Kazakhstan. Through its partnership with AAAG, AutoFlight is working to accelerate commercial deployment by supporting aviation innovation, smart infrastructure and regional connectivity.

“The demonstration flights in Astana are not a standalone event but part of a systematic effort to introduce urban air mobility in Kazakhstan. The country is steadily building a comprehensive ecosystem: the necessary legislation has been adopted, infrastructure development is underway, and international cooperation with leading global companies continues to expand. Our goal is to make innovative air transport an integral part of Kazakhstan’s transportation system,” said Sergey Khegay, Chief Executive Officer of AAAG.

“We envision our large-scale eVTOL technology transforming this region across multiple dimensionsfrom urban air mobility and intercity travel to aerial sightseeing, logistics and emergency response,” Kellen Xie, Senior Vice President of AutoFlight emphasized, “These applications represent not merely technological possibilities but a new paradigm of sustainable, zero-emission transportation for Central Asia.”

As AutoFlight continues expanding its global footprint, the company remains committed to working with governments, regulators and strategic partners worldwide to accelerate the commercialization of eVTOL technology and unlock new opportunities for sustainable air transportation.