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TCL appoints Olympic ski champion Eileen Gu as Global Brand Ambassador

SHENZHEN, China, Aug. 18, 2025 /PRNewswire/ — TCL, a global technology company, has appointed freestyle skier Eileen Gu as their Global Brand Ambassador. Her appointment is part of TCL’s commitment to advancing the Olympic Movement as a Worldwide Olympic Partner.

Having become the youngest Olympic champion in freestyle skiing at the age of 18, and the first freestyle skier to win three medals at a single Winter Olympic Games, Gu perfectly embodies TCL’s motto “Inspire Greatness”.

“I’m thrilled to take on this exciting new role as Global Brand Ambassador for Team TCL,” said Eileen Gu. “TCL shares in the mission to change the world through passion and courage. Every time I hit the slopes, I push myself in the pursuit of progress. TCL shows the same attitude with its fearless vision and bold innovations. With the Olympic Winter Games Milano Cortina 2026 approaching, I look forward to celebrating every moment of aspiration and triumph with TCL.”

Gu’s appointment resonates strongly with TCL’s “TCLforHer” initiative, a platform advocating for women’s visibility and empowerment through technology and culture. Through “TCLforHer”, TCL has funded female-focused programs and educational initiatives, providing support for more than 2,000 young women.

Eileen Gu is an athlete who pushes boundaries,” said Wei Xue, Vice President and ESG Director of TCL Technology, and Chairman of the TCL Charity Foundation. “Her spirit and passion align with our vision to empower more women to achieve extraordinary lives. TCL looks forward to building on our collaboration as we work towards next year’s Winter Olympics.”

In February, TCL announced its Worldwide Olympic and Paralympic Partnership with the International Olympic Committee (IOC) in the Home Audiovisual Equipment and Home Appliances category. Building on this milestone, TCL was added to the Donor’s Wall at the Olympic Museum in Lausanne, Switzerland, in June. A commemorative stone was unveiled in recognition of TCL’s contribution. The company also launched its first global campaign to celebrate Olympic Day, featuring members of the acclaimed Urban Theory Dance Crew who performed at Milan Cathedral and the TCL Chinese Theatre in Hollywood, Los Angeles, linking these two Olympic host cities in a dynamic film.

Leading up to the Olympic Winter Games Milano Cortina 2026, TCL will build on its 30-year legacy in sports and leverage its cutting-edge technology to elevate the experience of both fans and athletes at the event. Its digital displays will bring the magic of the Games from competition venues to billions of viewers around the world. Initiatives to support athletes include providing home appliances at the Olympic Villages and the “Athlete Moments” platform, which will enable competitors to connect with loved ones immediately after their performances.

TCL appointed freestyle skier Eileen Gu as their Global Brand Ambassador, committed to advancing the Olympic Movement as a Worldwide Olympic Partner.
TCL appointed freestyle skier Eileen Gu as their Global Brand Ambassador, committed to advancing the Olympic Movement as a Worldwide Olympic Partner.

About TCL

Founded in 1981, TCL—short for “The Creative Life”—embodies creativity in every aspect of life. As a leading technology company, TCL is dedicated to delivering innovative solutions—including TVs, smartphones, audio products, smart home devices, display technologies, and clean energy—that enhance customer experiences through TCL Industries and TCL Technology.

As of now, with 46 R&D centers and 38 manufacturing bases globally, TCL operates in over 160 countries and regions, cementing its position as a globally competitive smart technology brand. To further inspire greatness, TCL has become an official Worldwide Olympic and Paralympic Partner in the Home Audiovisual Equipment and Home Appliances category.

About The International Olympic Committee

The International Olympic Committee is a not-for-profit, civil, non-governmental, international organisation which is committed to building a better world through sport. It redistributes more than 90 per cent of its income to the wider sporting movement, which means that every day the equivalent of USD 4.2 million goes to help athletes and sports organisations at all levels around the world.

From Differentiation to Emotional Connection: 180 Brand Talk 6.0 Returns to Help Brands Win Hearts

  • Many SMEs start by asking how to make customers choose their brand.
  • But the real question is—if customers don’t like a brand, there’s no reason for them to choose it.

KUALA LUMPUR, MALAYSIA – Media OutReach Newswire – 18 August 2025 – To break through this challenge, it all comes down to one thing: building an emotional connection that wins hearts.

Past Brandtalk event photo year 2024

Brand positioning means that when customers encounter a problem, they immediately think of that brand. This can’t be achieved simply by spending on ads—it takes the right approach to make that brand truly resonate.

Addressing the pain points and blind spots of SMEs, Chan Fong has hosted five editions of 180 Brand Talk over the past three years, helping hundreds of businesses uncover their unique points of differentiation and build a brand positioning that is distinctly their own.

This session’s speaker, Chan Fong, is not only a well-known radio DJ but also a veteran advertising professional with 28 years of experience who, together with the team at 180 Degrees Brandcom, has spent more than two decades rebranding renowned brands such as OGAWA, CUCKOO, EcoWorld, Knife, BRAND’s and more, as well as guiding countless SMEs from the ground up to establish a solid foundation and define their positioning.

“Managing a brand isn’t about creating demand, but recognising it,” Chan Fong emphasises. A brand that truly wins hearts always has a clear image, a distinctive personality, and well-defined differentiation.

From long-term observations, Chan Fong found that about 70–80% of SMEs in Malaysia are run by the Chinese community, yet many of these brands lack an emotional connection with consumers. Even with strong and distinctive points of differentiation, they often struggle to communicate them effectively due to the wrong approach. To address this, Chan Fong launched the 180 Brand Talk programme, drawing on practical experience to guide SMEs in defining their brand positioning and building emotional connections.

What Makes This Programme Stand Out

In the 180 Brand Talk programme, Chan Fong avoids abstract theories and marketing jargon. Drawing on 28 years of hands-on experience, the programme shares numerous local case studies that reflect the real challenges faced by Malaysian SMEs, enabling entrepreneurs to relate easily and apply the lessons learned. The programme also features dedicated discussion sessions with the 180 team, where participants can present their brand’s pain points and receive practical, actionable advice.

Whether they are new entrepreneurs taking their first steps or seasoned brand owners stuck at a standstill, this programme helps businesses find their next breakthrough.

From Differentiation to Emotional Connection: 180 Brand Talk 6.0 Programme Details:

Date: 9–10 September 2025 (Tuesday–Wednesday)
Time: 10:00am–6:00pm
Venue: Courtyard by Marriott KL South

Remark: This programme is recognised under Malaysia’s Human Resources Development Fund (HRDF). Eligible companies may apply for HRDF reimbursement claims.

Special Offer:

Register now and use promo code TN200 to enjoy an RM200 discount per ticket! Limited seats are available—first come, first served.
Registration link: https://givingtreeglobal.com/upcoming-event/chan-fong-brand-talk/
Hashtag: #180BrandingStrategicGuideline #branding #brandtalk6.0 #BrandStrategy #BuildYourBrand #BrandVision #BrandPositioning #BrandDifferentiation



The issuer is solely responsible for the content of this announcement.

VVDN Acquires GGS Engineering, Expanding its ER&D Portfolio in Automotive, MedTech and Aerospace Industries

GURUGRAM, India, Aug. 18, 2025 /PRNewswire/ — VVDN Technologies, a global provider of software, product engineering and electronics manufacturing services & solutions, today announced the acquisition of GGS Engineering Services, a leading engineering solutions company specializing in offering enhanced ER&D services for the Automotive, MedTech and Aerospace industries. 

With this acquisition, VVDN has onboarded engineers with two decades of experience in Mechanical Design, Analysis, Simulation, Virtual Manufacturing and Technical Publications.

The key benefits of this acquisition for OEMs include:

  • Innovative Product Development with Accelerated Time-to-Market.
  • Value Added Engineering for Cost Optimization.
  • Scalable Engineering Talent Solutions.

The integration of GGS Engineering’s mechanical and electrical expertise with VVDN’s embedded systems and manufacturing prowess creates a unique vertically integrated solution for OEMs across key industries such as:

  • Automotive: GGS enables OEMs to create innovative designs that meet modern consumer expectations. VVDN now will be addressing the sector’s rapidly evolving needs for cabin designs, vehicle electrification, NVH (Noise, Vibration, Harshness) refinement, and cutting-edge styling and wire harness.
  • MedTech: VVDN will be serving MedTech customers with added portfolio by supporting them in the development of customized, precise, and efficient medical devices, implants, and surgical tools
  • Aerospace: Combined with GGS experience in CAD/CAM skillset, VVDN will be able to support OEMs and Tier 1s to design and manufacture complex aircraft components with precision and efficiency.

Together, VVDN & GGS set the stage for smarter machines, faster development, and stronger competitive advantages across industries. The combined entity will operate under the VVDN umbrella, with GGS’ leadership and founding teams continuing to play a pivotal role in the business.

Puneet Agarwal, CEO – VVDN Technologies: “We are delighted to welcome GGS Engineering Services into the VVDN family. Their proven excellence in mechanical engineering and design significantly enhances our value proposition to global clients. Our strengthened expertise now allows us to deliver comprehensive, cost-optimized product development for the automotive, medical, and aerospace industries—positioning VVDN to expand its footprint in automotive ER&D space. We look forward to working together to deliver accelerated innovation and end-to-end engineering leadership.”

This acquisition is a crucial step in VVDN’s growth strategy, enabling the company to aggressively penetrate the multi-billion-dollar global ER&D market and unlock new revenue opportunities across high-growth verticals.

Logo: https://laotiantimes.com/wp-content/uploads/2025/08/vvdn_technologies_logo.jpg

 

Hecto Financial, making STO investment easier, continues to provide payment solutions to Yeolmae Company

  • Following subscriptions for Yeolmae Company No. 1, 2, and 3, Hecto Financial has supplied payment solutions for the No. 5 subscription
  • No need to open a separate account, improving convenience for investors’ payments and reducing issuers’ costs
  • Plans to continue collaboration with Yeolmae Company and contribute to revitalizing the domestic STO market

SEOUL, South Korea, Aug. 18, 2025 /PRNewswire/ — Hecto Financial is lowering the barriers to STO investment with its account-based payment solution.

Fintech company Hecto Financial (KOSDAQ 234340, CEO Jong Won Choi) has provided its payment solution for the No. 5 investment contract securities of ‘Yeolmae Company,’ an operator of a fractional art investment platform.

Yeolmae Company recently completed the electronic disclosure with the Financial Supervisory Service for the No. 5 investment contract securities registration statement. The underlying assets of the No. 5 securities are the iconic work “Pumpkin (Untitled)” by world-renowned artist Yayoi Kusama and the solid gold piece “Golden Memories” by Zhang Xiaogang, called one of China’s “Four Heavenly Kings” of contemporary art. As before, Yeolmae Company is combining the two works for a joint issuance, with a total fundraising target of about KRW 800 million.

From July 18 to 24, Yeolmae Company carried out the subscription and payment process for No. 5-1 (Yayoi Kusama, “Pumpkin”), followed by No. 5-2 (Zhang Xiaogang, “Golden Memories”) from July 25 to 31.

As the issuer of Korea’s first investment contract securities, Yeolmae Company adopts Hecto Financial’s account-based payment solution, unlike most other fractional art investment platforms that primarily use securities accounts for payments.

Using Hecto Financial’s account-based payment solution to pay for investment contract securities eliminates the need to open a separate account, not only improving the convenience of payment for investors but also reducing issuance costs for the issuer.

A Hecto Financial representative stated, “Hecto Financial will continue to enhance payment convenience for investors in line with the expansion of Korea’s STO market, and will work closely with Yeolmae Company to help revitalize the domestic STO market.”

Hecto Financial is the only fintech company in Korea that owns the source infrastructure for all payment methods. Recently, in addition to STO payment solutions, it has been working on building a stablecoin distribution infrastructure. Based on its proprietary settlement system under the Electronic Financial Transactions Act, along with AML (Anti-Money Laundering) and Travel Rule compliance systems, Hecto Financial plans to expand its digital asset–based payment ecosystem through partnerships with various domestic and overseas stablecoin issuers and merchants.

STO (Security Token Offering) is a financial service that issues real-world assets as blockchain-based tokens, enabling “fractional investment.” It allows high-value assets, such as artworks or real estate, to be issued and made available for investment in small amounts. Meanwhile, in Korea, STO-related legislation is currently awaiting review, with institutionalization on the horizon.

About Hecto Financial

Hecto Financial is a company that, based on its leading position in cash-based easy payment solutions, provides a wide range of payment services—including firm banking, municipality-specific services, PG (payment gateway), and VAN (value-added network)—to the public sector, financial institutions, e-commerce, and platform industries. In particular, it focuses on settlement and remittance solutions for global e-commerce, expanding its presence in the fintech business sector.

New support group to provide social and community support for neurofibromatosis patients

Co-founded by individuals living with this rare genetic condition, the Neurofibromatosis Society Singapore seeks to close gaps in mental and emotional care

SINGAPORE, Aug. 18, 2025 /PRNewswire/ — A new patient-led support group, the Neurofibromatosis Society (NFS) Singapore, has been recently registered with the Registry of Societies to provide emotional, psychosocial, and financial support for people affected by neurofibromatosis (NF) – a rare genetic condition that causes the development of tumours affecting nerves on the skin, brain, spinal cord and other parts of the body.

The group participated in the inaugural Regional Rare Skin Patients Support Group Summit 2025, jointly organised by the Asian Society of Pediatric Dermatology (ASPD) and the Rare Skin Conditions Society Singapore (RSCS). Titled “Beyond the Surface”, the summit saw representatives from across Southeast Asia coming together to discuss the needs of those living with rare skin conditions.  

In Singapore, the number of individuals with NF is estimated to be in the hundreds, with NF Type 1 (NF1) being the most common diagnosis. NF1 manifests through symptoms such as multiple flat, light brown spots on the skin – known as “café au lait” spots – and soft bumps under or on the skin, called neurofibromas.[1],[2] Patients are primarily treated at multi-disciplinary clinics established in recent years at the National Cancer Centre Singapore (NCCS) and KK Women’s and Children’s Hospital (KKH), where they can receive comprehensive care.

To further enhance patient support, healthcare providers from both institutions will work closely with NFS Singapore to provide guidance and care through a range of initiatives, including patient-led events, outreach and advocacy. Dr Nikki Fong, Consultant, Genetic Service at KKH, together with Clinical Assistant Professor Chiang Jianbang, Consultant, Cancer Genetics Service, NCCS, will be working closely with the group to guide their efforts and create a welcoming platform where NF patients can share their experiences and knowledge, helping them connect and build a strong support network.

“There is power in connection. Knowing you are not alone on this journey can be truly life-changing, whether you are a child or adult,” said Yessika Sutawijaya, 44, a co-founder of the group who was diagnosed at the age of eleven. “We hope that with NFS Singapore, we can help others on a similar journey find strength and live life fully, even in the face of challenges.”

As NF is often underdiagnosed, many patients live with feelings of isolation and a lack of information. This is often made worse by the social stigma and misunderstandings that come with visible changes in appearance, which can affect self-esteem and overall quality of life from childhood through adulthood.[3],[4]  

“Growing up with a rare, lifelong condition like NF can be especially challenging for children – not just physically, but emotionally and socially as well,” said Dr Fong. “Beyond medical treatment, young patients and their families need continual emotional and mental support. This group will play a pivotal role in addressing those unseen needs, complementing the clinical journey with peer and psychological support.”

Lai Chee Chong, 45, another co-founder of NFS Singapore, reflected on his own childhood, “As a child, living with NF affected my self-confidence. I found it difficult to make friends because people thought my condition was contagious. Now, I want to help create more awareness on NF.”

NFS Singapore was established in close collaboration with organisations such as RSCS, and with the support of corporates such as biopharmaceutical company AstraZeneca.

Ms Kim Suyeon, Country President, AstraZeneca Singapore, said, “AstraZeneca is committed to supporting an initiative that puts patients with NF at the heart of everything, ensuring they feel seen, heard, and supported beyond clinical care.”

Notes

This information has been provided to facilitate patient education and disease awareness only. It is not a complete guide to neurofibromatosis. For more information, please speak to your healthcare provider.

Approval code: SG-9695_CA_150825


[1]
 Tamura R. Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis. Int J Mol Sci. 2021;22:5850.

[2] Ly K, et al. The diagnosis and management of neurofibromatosis type 1. Med Clin North Am. 2019;103(6):1035-1054.

[3] Fournier, Hugo et al. Psychosocial implications of rare genetic skin diseases affecting appearance on daily life experiences, emotional state, self-perception and quality of life in adults: a systematic review. Orphanet journal of rare diseases. 2023; 18(1):39

[4] Cavallo, Nicola Davide et al. Neuropsychiatric Manifestations, Reduced Self-Esteem and Poor Quality of Life in Children and Adolescents with Neurofibromatosis Type 1 (NF1): The Impact of Symptom Visibility and Bullying Behavior. Children (Basel, Switzerland); 2023; 10(2): 330.

 

A New Booster of Intelligent Manufacturing in Guizhou: How Does New Digital Infrastructure Empower Industrial Upgrading?

GUIYANG, China, Aug. 18, 2025 /PRNewswire/ — A news report by Huanqiu.com:

Formerly developing the traditional chemical industry by relying on minerals and other resources, Guizhou Province is leveraging the powerful booster of new digital infrastructure now to inject the impetus of intelligent manufacturing into made-in-Guizhou products.

Massive industrial data have been congregated and deeply integrated in the digital economic network woven by computing power and algorithms, from the precise dispatching of smart logistics networks run by phosphorus chemical enterprises, to the efficiency leap of intelligent production lines operated by electronic manufacturers, and to the development of new energy vehicle industrial clusters, so as to accelerate the transformation and upgrading of the traditional manufacturing sector into high-end, intelligent and green development.


At the logistics center of Guizhou Phosphorus Chemical Group, the smart logistics system is operating efficiently with the features of “double channels and triple ports”. The group’s phosphorous products are exported via the ports of Zhanjiang and Fangchenggang through sea-rail combined transportation; meanwhile, sulfur imported from the Middle East is delivered to China’s domestic market through the southbound channel. Thanks to the flexible dispatching strategy of the three interactive ports, the group has optimized the distribution and flow of carrying capacity within the framework of multimodal transportation. Such cost-efficient “phosphorus-sulfur swap” model annually saves logistics costs of more than 40 million yuan on the manufacturing side.

Digital empowerment means more. The group plans to upgrade its logistics system so that through accumulating logistics big data and integrating empirical data into algorithm models, intelligent decision-making will be achieved in terms of vendor selection, smart dispatching and carrying capacity organization.

Such practice goes beyond the optimization of supply chains, but marks the systematic reconstruction of a traditional chemical enterprise’s core operation pattern by utilizing digital technologies. Such digitalization-driven industrial transformation is also taking place in the sector of electronic information manufacturing.

At the production workshop of Guiyang Hisense Electronics Co., Ltd., highly automated production lines are running smoothly in an orderly manner. The production of all 24″-85″ large LCD flat-panel TVs is completed with automated equipment in the whole process from material selection from warehouse and material recycling to the assembly of LCD panels and back panels. As the “brain” of the smart plant, the centralized control system collects and analyzes production data, and establishes an all-encompassing management and traceability system for product information.

Since its intelligent transformation at a faster pace in 2016, Guiyang Hisense Electronics has become the second enterprise to pass the assessment and certification of Grade-3 Intelligent Manufacturing Maturity in Guizhou, and realized a leap of production capacity and revenue by increasing its annual output from 1.9 million units to 3.32 million units and its annual output value from 6.5 billion yuan to 9.5 billion yuan.

Similarly, profound intelligent transformation is underway at the manufacturing base of Geely Auto in Guiyang. Inside the production workshop, it takes only a bit over one minute to assemble a new car through the precise operation of robotic arms and shuttling travel of intelligent logistics robots. Such intelligent production system effectively supports the fast mass production of star automotive models. In 2024, the base successfully delivered more than 10,000 Galaxy E5 pure electric SUVs within 20 days since the launch of the model, and has gained a total global sales volume of over 150,000 units by July 2025.

The base has also extended its intelligent manufacturing capacity to core components. Not far from the production workshop, the ShenDun battery project developed independently by Geely Auto was launched into service only after ten months from the commencement of its construction. Over the past decade since Geely Auto settled in Guiyang, more than 40 auto part manufacturing enterprises have been established in the city, with a localization rate of up to 48% and a cumulative output value of over 20 billion yuan. A complete ecosystem has been created to cover vehicle manufacturing, auto parts manufacturing, mobility and sales.

The industrial revolution is pillared by new digital infrastructure constructed in Guizhou. Led by the Ascend AI Adaptation Center in Guizhou, more than 60 entities have developed a collaborative innovation model of “training in Guizhou, reasoning nationwide”, reporting a 100% adaptation and acceptance rate. At the Guiyang Big Data Exchange, a total of 939 high-quality datasets are unleashing their value in various fields like medical care and industrial production. The Guizhou Data Development & Utilization & Processing Base inaugurated in May 2025 is concentrating on the R&D of AI automatic annotation technology to improve the accuracy and efficacy of its data annotation.

From Hisense’s intelligent plant to Guizhou Phosphorus Chemical Group’s smart logistics, and to Geely Auto’s intelligent manufacturing ecology, new digital infrastructure acts as a “nervous system” penetrating through the “muscles” of the manufacturing sector in Guizhou, converting traditional productive forces into new quality productive forces. Fueled by the convergence of data and computing power in Guizhou, a mountainous province, the new booster of intelligent manufacturing is propelling the industrial transformation and upgrading in western China on a new development path.

NEV Dark Horse! LEPAS L8 Shapes the Aesthetics of Sophisticated Driving with Technological DNA

WUHU, China, Aug. 18, 2025 /PRNewswire/ — Chery Group’s new energy vehicle (NEV) brand LEPAS has made an impressive overseas debut with newest L8 model. With its”Positive New Energy” pedigree, the L8 integrates Chery Group’s global technology matrix and forward-development philosophy, blending cutting-edge innovation with refined aesthetics to set a new benchmark for sophisticated driving experiences.

NEV Dark Horse! LEPAS L8 Shapes the Aesthetics of Sophisticated Driving with Technological DNA
NEV Dark Horse! LEPAS L8 Shapes the Aesthetics of Sophisticated Driving with Technological DNA

Chery Group, one of China’s earliest hybrid technology pioneers, is accelerating its transition into the NEV sector. Supported by its three core pillars — full-chain core technology mastery, safety-first standards, and an open global ecosystem — Chery delivers vehicles that excel in efficiency, performance, intelligence, safety, and off-road capability.

As of July 2025, Chery had over 17.18 million global users, including over 5.17 million overseas. From January to July, the Group sold 424,737 NEVs — an 87.7% year-on-year increase — ranking it among the fastest-growing NEV manufacturers. July exports reached 119,090 units (up 31.9% YoY), with hybrid models showing strong growth.

Born from Chery’s deep R&D heritage, the LEPAS L8 is built on a dedicated NEV platform and represents a new benchmark in forward development. Its Super Hybrid System delivers 44.5% thermal efficiency, 4.2L/100km fuel consumption in battery-depleted mode, and a combined range exceeding 1,400 km — achieving a “performance triangle” of efficiency, endurance, and power. Even in zero-fuel-consumption mode, the L8’s climate system runs for 4 hours, maintaining cockpit comfort without compromise.

Reflecting the “Positive New Energy” philosophy, the L8’s design blends aerodynamic efficiency and modern aesthetics. Semi-flush door handles reduce drag and enhance its tech-forward design. Inspired by “Leopard Aesthetics,” the L8 combines agility and strength with vertical headlamps and flowing contours to create a striking profile.

Inside, the L8 embraces the “Sophisticated Drive” concept, transforming the cockpit into a “Refined Third Space.” At 4,688 mm in length with a 2,800 mm wheelbase, it targets the mainstream SUV market. A wraparound cockpit, clean interface, and intelligent interaction system offer minimalist luxury. Ergonomic seats and smart tech enhance comfort and usability, ideal for both daily life and travel.

In today’s NEV market, the L8 demonstrates that a truly premium NEV experience is about understanding user needs and innovation, embodying Chery’s “Positive New Energy” philosophy.

Ascletis Announces the Combination of ASC47 and ASC31, its Dual GLP-1R/GIPR Peptide Agonist, Demonstrated Significantly Greater Weight Loss Compared to the Combination of ASC47 and Tirzepatide in an Animal Model of Obesity

–  Combination of a low dose of ASC47 with ASC31, a novel peptide agonist targeting both GLP-1 receptor (GLP-1R) and GIP receptor (GIPR), resulted in a 44.8% reduction in body weight after 14 days of treatment in a diet-induced obese (DIO) mouse model.

–  Combination of a low dose of ASC47 with ASC31 demonstrated statistically significantly greater efficacy than a combination of a low dose of ASC47 with tirzepatide, 44.8% compared to 38.1%, respectively, in the DIO mouse model.

HONG KONG, Aug. 18, 2025 /PRNewswire/ — Ascletis Pharma Inc. (HKEX:1672, “Ascletis”) announces encouraging preclinical efficacy results for ASC47, a first-in-class muscle-preserving weight loss drug candidate for the treatment of obesity, in combination with ASC31, its in-house developed GLP-1 receptor (GLP-1R)/GIP receptor (GIPR) dual targeting peptide agonist drug candidate.

ASC31 is an in-house discovered and developed novel peptide agonist targeting both GLP-1R and GIPR, which demonstrated a favorable pharmacokinetic profile in non-human primates as well as promising in vitro activities and in vivo efficacy in the diet-induced obese (DIO) mice. ASC31 is part of Ascletis’ discovery efforts to apply its Ultra-Long-Acting Platform (ULAP) to in-house discovered novel subcutaneously (SQ) injectable peptides and oral peptides.

ASC47 is an adipose-targeted, once-monthly SQ injected thyroid hormone receptor beta (THRβ) selective small molecule agonist, discovered and developed in-house at Ascletis. ASC47 possesses unique and differentiated properties to enable adipose targeting, resulting in dose-dependent high drug concentrations in the adipose tissue.

The objective of the DIO mouse study was to compare efficacy in weight loss of a low dose of ASC47 (9 mg/kg, SQ) combined with ASC31 (3 nmol/kg, SQ) to a low dose of ASC47 (9 mg/kg, SQ) combined with tirzepatide (3 nmol/kg, SQ). The treatment duration was 14 days. Results showed that the combination of ASC47 with ASC31 was 17.6% more effective (p=0.02) compared to the combination of ASC47 with tirzepatide, with an average total body weight reduction of 44.8% versus 38.1%, respectively. 

“The significant weight reduction demonstrated with the combination of our novel GLP-1R/GIPR peptide agonist, ASC31, and our THRβ agonist, ASC47, in this animal model suggests the potential for meaningful differentiation compared to currently marketed obesity treatments as well as product candidates in development,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, “Ascletis is developing a strong pipeline of small molecules and peptides for the potential treatment of obesity, and we look forward to providing additional development updates moving forward.”

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) Platform and Ultra-Long-Acting Platform (ULAP), Ascletis has developed multiple drug candidates in-house, including its lead program, ASC30, a small molecule GLP-1R agonist in development as a once-daily oral tablet and once-monthly subcutaneous injection for weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

For more information, please visit www.ascletis.com.

Contact:

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com

Ascletis Pharma Inc. PR and IR teams
+86-181-0650-9129 (China)
pr@ascletis.com
ir@ascletis.com