• Breakthrough Therapy Designation was granted for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) who have had prior treatment with platinum-based chemotherapy and anti-PD-(L)1 antibody but have not been previously treated with a KRAS G12C inhibitor
• Orphan Drug Designation was granted for treatment of colorectal cancer (CRC) harboring KRAS G12C mutant protein.

SHANGHAI, Aug. 28, 2025 /PRNewswire/ — D3 Bio, Inc, a clinical-stage oncology company focuses on discovery and development of precision oncology therapies, today announced that the U.S. Food and Drug Administration (FDA) has granted a Breakthrough Therapy Designation to D3S-001, the company’s next generation KRAS G12C-selective inhibitor, for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC who have received prior chemotherapy and immunotherapy but have not been previously treated with a KRAS G12C inhibitor. Additionally, D3S-001 has been granted Orphan Drug Designation for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic CRC.

The Breakthrough Therapy and Orphan Drug Designations are based on clinical data from an ongoing Phase 1/2 study (NCT05410145) evaluating D3S-001 in patients with advanced solid tumors harboring a KRAS G12C mutation. Results from this ongoing clinical trial demonstrated highly compelling and durable efficacy according to RECIST (Response Evaluation Criteria in Solid Tumors) with a favorable safety and tolerability profile.

“We are very pleased to receive both Breakthrough Therapy and Orphan Drug Designations from the FDA for D3S-001, which highlights D3S-001’s promising potential to address critical unmet needs in patients with KRAS G12C-mutated cancers,” said George Chen, Founder and CEO of D3 Bio. “These designations also recognize D3S-001’s novel profile as a next-generation KRAS G12C inhibitor. We look forward to bringing this exciting new treatment to patients with support and collaboration from health authorities.”

KRAS mutations are among the most common oncogenic drivers in human cancers, found in approximately 25 to 30% of all tumors. The KRAS G12C mutation occurs in approximately 12% of NSCLC cases and 3 to 4% of CRC. Patients with KRAS G12C-mutated cancers often have more aggressive disease and limited responses to standard therapies, such as immunotherapy and/or chemotherapy.

About D3S-001

D3S-001 is a next-generation KRAS G12C inhibitor designed to achieve rapid and complete KRAS G12C target engagement. D3S-001 potently, selectively, and covalently binds to the oncogenic RAS (Off) form of the RAS G12C variant, functionally abolishing the nucleotide cycling between RAS (Off) and RAS (On) forms of the G12C mutant protein. In preclinical investigations, D3S-001 demonstrated high covalent potency, complete engagement of KRAS G12C at clinically relevant doses and CNS penetration properties. D3S-001 is currently under evaluation as monotherapy and in combination regimens in a Phase II global clinical trial in patients with advanced solid tumors harboring KRAS G12C mutations, including NSCLC, CRC, and other tumor types. Key publications:

• D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities. Cancer Discov. (2024)14 (9):1675–1698.
• D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial. Nat Med. 2025 Aug;31(8):2768-2777.

About D3 Bio

D3 Bio is a global biotechnology company focused on the discovery, development, and registration of new medicines in oncology and immunology. The company’s discovery and development platforms leverage proprietary clinical insight and biomarker strategies to create novel and clinically meaningful therapies for patients in need. D3 Bio’s oncology programs target driver mutations or critical immune pathways and are designed to have first-in-class or best-in-class potential. D3 Bio owns global rights for all of its programs. For more information, please visit www.d3bio.com.

Contacts

Media Contact:
Rui Liu
Head, Corporate Affairs
bd@d3bio.com

• IMG took a sample of its customers and reviewed more than 30,000 travel itineraries of members with upcoming travel plans between September 1^st and November 30^th of 2025 to determine emerging travel trends this autumn.

INDIANAPOLIS, Aug. 28, 2025 /PRNewswire/ — IMG (International Medical Group) has conducted a review of customers’ travel plans from the beginning of September to the end of November and predicts this autumn’s top 5 international destinations for U.S. travelers to be:

1. Mexico – top country 3 years in a row
2. Italy
3. United Kingdom
4. Canada
5. Spain

IMG data shows a 13% increase in the average insured trip cost among IMG travelers this autumn compared to the same time period in 2024, and those planning to travel this season will be taking trips averaging 11 days in length, which is two days longer than the average for autumn 2024 travelers.

With longer trips and more money invested in their travels, more travelers want to make sure their trip investment is protected. IMG has seen more than a 50% increase in travel protection plan purchases among travelers this autumn compared to last autumn.

“As travelers plan longer and more expensive trips this autumn, we’re seeing a clear shift toward prioritizing protection and peace of mind,” said Justin Poehler, IMG Chief Commercial Officer. “With the increase in travel protection plan purchases, it’s evident that travelers are taking a more thoughtful approach to planning their experiences abroad.”

To learn more about IMG’s award-winning travel and health safety solutions, please visit www.imglobal.com.

About IMG^® (International Medical Group^®)
IMG^® (International Medical Group^®), a SiriusPoint company, is an award-winning global insurance benefits and assistance services company that has served millions of members worldwide since its founding in 1990. The preeminent provider of travel and health safety solutions, IMG offers a wide range of insurance programs, including international private medical insurance, travel medical insurance, and travel insurance, as well as enterprise services, including insurance administrative services and 24/7 emergency medical, security, and travel assistance. IMG’s world-class services, combined with an extensive product portfolio, provide Global Peace of Mind^® for travelers, students, missionaries, marine crews, and other individuals or groups traveling, working, or living away from home. For more information, please visit www.imglobal.com.

Media Contact: Carly Kessler, IMG Communications Manager, carly.kessler@imglobal.com

ASHBURN, Va., Aug. 28, 2025 /PRNewswire/ — DXC Technology (NYSE: DXC), a leading Fortune 500 global technology services provider, has been named a Leader in the “IDC MarketScape: Worldwide Industrial IoT End-to-End Engineering and Life-Cycle Services 2025 Vendor Assessment*.” The recognition highlights DXC’s Industrial IoT services to enhance operations and provide greater visibility into the supply chain for industries that rely heavily on physical assets like property, machinery, and equipment.

DXC Named a Leader by IDC MarketScape in Industrial IoT End-to-End Engineering and Lifecycle Services

“To help our customers unlock the full potential of Industrial IoT, we combine deep industry expertise, digital twin technology, and IoT which creates a more comprehensive capability around simulation, process engineering, and recovery,” said Pete McEvoy, Head of Data and AI at DXC. “We believe this recognition by the IDC MarketScape highlights our industry expertise and value as a trusted partner, delivering measurable business outcomes as our clients navigate their digital transformation journey.”

DXC delivers IIoT services using a consistent approach that was designed by its industry experts, delivering the following benefits across manufacturing:

• Asset Management: Lower maintenance costs and optimize production and scheduling.
• Incident Mitigation: Rapidly detect, assess, and resolve failures, quality issues, or disruptions across manufacturing, supply chains, and asset-intensive operations.
• Quality Control: Minimize waste, defects, and rework by identifying product or supply chain issues early and triggering near real-time alerts through custom apps and interfaces.
• ESG Compliance: Gain real-time visibility into energy use, analyze consumption and pricing trends, boost efficiency, reduce energy costs, and prevent waste.

“IDC Identifies DXC’s strength as its comprehensive Industrial IoT solutions and services portfolio, proprietary frameworks for IIoT and Industry 4.0 solutions and services and delivery ecosystem. DXC’s clients highly appreciate its focus on meeting the business KPIs, proactiveness in bringing new Industrial IoT and Industry 4.0 use cases and showcasing of ROI implications upfront. Its onshore and nearshore heavy model further resonates well with its customers in terms of delivery effectiveness and efficiency. DXC’s investments in R&D, partnerships and extending its delivery ecosystems to other high growth markets are expected to bolster its position in the market and confidence amongst its clients,” said Abhishek Mukherjee, Research Manager, Digital Engineering and Operational Technology Services at IDC.     

DXC helps enterprises design, deploy and manage secure, scalable Industrial IoT and digital twin solutions, powering smart factories, connected operations, and advanced public services such as healthcare, traffic management, and aerospace and defense. Our strategies have delivered maintenance cost savings across fleets, equipment, and machines, and ROI through improved production visibility and quality in manufacturing and supply chain.

This first IDC MarketScape for IIoT end-to-end engineering and life-cycle services evaluated 15 vendors. This evaluation provides a combined view of these service providers’ capabilities in IIoT strategy/consulting, systems integration, engineering, and managed services. 

An excerpt of the IDC MarketScape report and more information on its methodology is available to view here. To learn more about DXC’s IIoT and Digital Twin Services, click here. More information on DXC’s expertise in the manufacturing sector can be found here.

About IDC MarketScape:  
IDC MarketScape vendor assessment model is designed to provide an overview of the competitive fitness of technology and service suppliers in a given market. The research utilizes a rigorous scoring methodology based on both qualitative and quantitative criteria that results in a single graphical illustration of each supplier’s position within a given market. IDC MarketScape provides a clear framework in which the product and service offerings, capabilities and strategies, and current and future market success factors of technology suppliers can be meaningfully compared. The framework also provides technology buyers with a 360-degree assessment of the strengths and weaknesses of current and prospective suppliers. 

About DXC Technology
DXC Technology (NYSE: DXC) is a leading global provider of information technology services. We’re a trusted operating partner to many of the world’s most innovative organizations, building solutions that move industries and companies forward. Our engineering, consulting and technology experts help clients simplify, optimize and modernize their systems and processes, manage their most critical workloads, integrate AI-powered intelligence into their operations, and put security and trust at the forefront. Learn more on dxc.com.

* Doc # US51812924, August 2025

Angelena Abate, Media Relations, +1.646.234.8060, angelena.abate@dxc.com

Institutional users can choose between instant spot and options OTC and fully-managed bespoke execution to meet their needs

DUBAI, UAE, Aug. 28, 2025 /PRNewswire/ — Binance, the world’s largest cryptocurrency exchange by trading volume and users, today announced it has upgraded its Execution Services to aggregate spot and options liquidity from an extensive network of liquidity providers, in addition to the exchange’s deep and proprietary native order books. The new approach prioritizes flow internalization, helping large-volume users improve speed, price performance, and execution time. Depending on their requirements, users can choose between OTC risk-pricing, and bespoke execution whereby the execution desk will leverage Binance’s algorithmic capabilities and market leading liquidity.

Binance supports two primary types of algorithmic trading, Time Weighted Average Price (TWAP) and Percentage of Volume (POV), and users can directly manage their own algorithmic trade through the Binance VIP Portal as well as request for Binance VIP assistance in running their trading where they can specify certain instructions.

As with traditional finance, over-the-counter or OTC trading lets users secure risk-pricing for large transactions to minimize slippage and avoid impacting the market, especially for illiquid assets. Binance will aggregate and submit the most competitive live OTC quotes when users initiate a request, and the trade can settle in as little as 15 minutes, a significant improvement over the industry standard of T+1. Users also have the flexibility of choosing a longer settlement window to fit their liquidity needs.

Binance Execution Services appeals to a wide range of institutional and sophisticated users, including:

• Large-volume traders: users can lock in pricing for large-volume trades to minimize slippage they otherwise can encounter when trading on the order book
• Long-time holders and less active “whales”: long-time holders with infrequent trading experience can find it more convenient and efficient to outsource execution
• Mid-sized entities: market participants such as mid-sized hedge firms can utilize OTC trading to complement their trading strategies and better compete
• High-frequency trading firms: participants that transact in high frequency trading can opt to become liquidity providers and leverage their very high volume requirements

“Clients who prioritize pricing and speed for larger trades will enjoy our enhanced OTC service, and clients who prefer bespoke execution can also rely on us to fully manage the process for them. By tailoring solutions for the different segments, we help sophisticated clients from high-net-worth individuals and family offices to larger institutions optimize their crypto experience,” commented Catherine Chen, Head of VIP & Institutional at Binance.

The number of VIP and institutional users on Binance grew by 21% and 20% respectively in H1/2025 as compared to H1/2024. Trading volume for the two categories grew by 10% and 12% respectively for the same period.

“We are enhancing our execution capabilities alongside our other offerings to ensure we continue to be well-positioned to support our institutional clients’ growing demand for exposure to crypto,” added Chen.

Institutional users can explore how Binance can enhance their trading experience by visiting Binance Execution Services or contacting Binance VIP & Institutional here.

Disclaimer: The products and services referred to herein may be restricted in certain jurisdictions or regions or to certain users, in accordance with applicable legal and regulatory requirements. These materials are intended only for those users who are permitted to access and receive the products and services referred to and are not intended for users to whom restrictions apply. Digital asset prices are subject to high market risk and price volatility. The value of your investment may go down or up, and you may not get back the amount invested. You are solely responsible for your investment decisions and Binance is not liable for any losses you may incur. Past performance is not a reliable predictor of future performance. You should only invest in products you are familiar with and where you understand the risks. You should carefully consider your investment experience, financial situation, investment objectives and risk tolerance and consult an independent financial adviser prior to making any investment. This material should not be construed as financial advice. For more information, see our Terms of Use and Risk Warning.

About Binance

Binance is a leading global blockchain ecosystem behind the world’s largest cryptocurrency exchange by trading volume and registered users. Binance is trusted by more than 280 million people in 100+ countries for its industry-leading security, transparency, trading engine speed, protections for investors, and unmatched portfolio of digital asset products and offerings from trading and finance to education, research, social good, payments, institutional services, and Web3 features. Binance is devoted to building an inclusive crypto ecosystem to increase the freedom of money and financial access for people around the world with crypto as the fundamental means.

For more information, visit: https://www.binance.com 

About Binance VIP & Institutional

Binance VIP & Institutional empowers institutions and private wealth clients with robust asset management infrastructure, personalized VIP services and advanced end-to-end institutional trading tools on the world’s largest cryptocurrency exchange by trading volume and registered users. With deep financial services experience in both traditional and crypto markets, its global team of trusted experts provides VIP & Institutional clients with the support they need to confidently capitalize on the industry’s deepest liquidity and tightest markets.

For more information, visit: https://www.binanceinstitutional.com

Innovative technology for all, from content creators and movie producers to enterprise and agricultural workers

BERLIN, Aug. 28, 2025 /PRNewswire/ — DJI, the global leader in civilian drones and creative camera technology, will be showcasing its innovative product portfolio at IFA 2025. From 5^th-9^th September, visitors to IFA will have the opportunity to experience DJI’s innovative solutions first-hand.

Experience DJI’s Latest Creative Camera, Sound, and Drone Technology

• Osmo 360: As the company’s first foray into 360 cameras, the Osmo 360 features 1-Inch 360° imaging and native 8K 360° video with large 2.4μm pixels to elevate existing industry standards, bringing creators the flexibility needed for any creative vision.
• DJI Mic 3: DJI’s latest ultralight wireless microphone offering powerful performance and unmatched versatility. Mic 3 features 4TX + 8RX capability, timecode, dual band anti-interference, and more smart functions to make the recording experience as simple as possible.
• Camera Drones: Explore the unique characteristics of DJI’s drone line-up—the Mavic 4 Pro with its 360° rotation Infinity Gimbal, the Avata 2 delivering an immersive flight experience, the Air 3S featuring a dual-camera for travel photography, Flip and Neo, with subject tracking for effortless lifestyle capture, or the regulation-friendly Mini 4 Pro, weighing under 250g for hassle-free flying. 
• Creators Favourites: If you’re looking for a camera to capture the action or a daily vlog, take a look at the Osmo Action 5 Pro, Osmo Pocket 3, with prosumer sound capture from Mic 3.

Industry Leading Stabilization and Image Transmission for All

Designed to boost creativity, DJI has a full range of camera gimbals for everyone from the solo content creator to full-scale movie producers. Highlights include:

• DJI RS 4 Mini: The compact and lightweight gimbal for cameras and smartphones that weighs just 890g, featuring intelligent tracking and composition, it empowers content creators with a more efficient filming experience.
• DJI RS 4 Pro: DJI’s flagship stabilizer integrates seamlessly with the DJI Focus Pro lens control system, DJI Transmission and DJI SDR Transmission, and an extensive control ecosystem. This synergy empowers the film and television industry with a full-scale production solution.
• DJI Ronin 4D: DJI’s advanced technologies have been integrated into one cutting-edge and comprehensive cinematography solution, designed and built to be the new trend of filmmaking.
• DJI SDR Transmission: Built around Software-Defined Radio technology, the system utilizes both SDR and Wi-Fi video transmission modes. SDR technology takes video transmission performance to a whole new level, offering enhanced stability, interference resistance, and penetration capabilities. 

Power Your World with DJI’s Range of Portable Power Stations

IFA 2024 saw the introduction of DJI’s Power 1000 and 500. This year the range has expanded to include the latest Power 2000 and Power 1000 V2, providing flexible power for home backup, road trips, outdoor camping, film and TV production, and more.

In Germany, Spain, France, among other European countries, users can even connect their Power 2000 and balcony solar system to the national grid to benefit from power savings. Recharge the power station with solar panels during the day, and once the power station is fully charged, the excess electricity will be fed into the grid.

Accessories such as solar panels, fast chargers and hand trucks, for home and outdoor use, will also be on display.

Work Smarter with DJI Delivery, Enterprise and Agriculture Solutions

Discover the Matrice 400, Matrice 4 Series, Dock 3, Agras T50, Mavic 3M and Flycart 30, all designed to enhance operational efficiency and productivity across various industries.

Learn, Create, and Share

To foster creativity and skill development, DJI will host a series of professional and consumer workshops led by filmmaking experts and talented content creators. These workshops are open to all IFA visitors, offering insights into creating high-quality content with ease.

Workshops will run twice a day on the 6^th and 7^th September, one at 11am focused on drones and one at 3pm focused on handheld products.

See You at IFA

IFA will open its doors at Messe Berlin from 5^th-9^th September, 2025. Visit DJI’s booth in Hall 20-149 to experience these innovations and witness the future of drone, camera, gimbal, and portable power technology.

About DJI

Since 2006, DJI has led the world with civilian drone innovations that have empowered individuals to take flight for the first time, visionaries to turn their imagination into reality, and professionals to transform their work entirely. Today, DJI serves to build a better world by continuously promoting human advancement. With a solution-oriented mindset and genuine curiosity, DJI has expanded its ambitions into areas such as renewable energy, agriculture, public safety, surveying and mapping, and infrastructure inspection. In every application, DJI products deliver experiences that add value to lives around the world in more profound ways than ever before.

For more information, visit our:
Website: www.dji.com
Online Store: store.dji.com
Facebook: www.facebook.com/DJI
Instagram: www.instagram.com/DJIGlobal
X: www.x.com/DJIGlobal
LinkedIn: www.linkedin.com/company/dji
Subscribe to our YouTube Channel: www.youtube.com/DJI 

NEW YORK, Aug. 28, 2025 /PRNewswire/ — The New York Stock Exchange (NYSE) provides a daily pre-market update directly from the NYSE Trading Floor. Access today’s NYSE Pre-market update for market insights before trading begins. 

Ashley Mastronardi delivers the pre-market update on August 28th

• Investors Digest Nvidia’s Q2 earnings
• The S&P 500 is coming off a record close
• GDP and weekly jobless claims data out before market open

Opening Bell
Energy Council celebrates the New York Energy Capital Assembly conference and all of NYSE’s energy issuers

Closing Bell
YTexas celebrates its 5^th annual summit, which aims to assist high-growth organizations accelerate their presence in Texas

Click here to download the NYSE TV App