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Meituan Black Pearl Restaurant Guide Makes Overseas Debut in Singapore: Record-High Southeast Asian Listings, Connecting Global Chinese Communities with World Cuisine

SINGAPORE, April 28, 2025 /PRNewswire/ — Meituan, China’s leading technology-driven retail company, hosted the first-ever overseas ceremony of its renowned “Black Pearl Restaurant Guide” (the “Black Pearl”) at Marina Bay in Singapore on April 25. As it expands globally and embraces cutting-edge AI technologies, Meituan not only seeks to help users worldwide eat better and live better, but also to unlock new business opportunities for culinary brands across the globe.

As the first international food guide rooted in Chinese dining standards, the “Black Pearl” has served approximately 130 million users since its inception. This year, the Guide shines a spotlight on 55 overseas restaurants, marking the fifth consecutive year of growth in international listings. Tokyo leads the way with 30 restaurants, while Singapore and Bangkok each achieved record highs since the guide’s debut in 2018. Notably, two Singaporean restaurants earned the highest honor—the prestigious 3-Diamond rating this year.

Wei Wei, Vice President of Meituan and the company’s head of the in-store dining division, described the ceremony as a major milestone in the global expansion of Meituan’s ranking products. He highlighted the platform’s use of advanced AI technologies to streamline user decision-making. Moving forward, Meituan aims to integrate AI and expertly curated recommendations to seamlessly connect users with quality restaurants, hotels, and attractions, enabling efficient connections between consumers and premium businesses.

Over Half of Chinese Tourists Show Strong Preference for Fine Dining When Travelling Abroad; Southeast Asia’s “Black Pearl” Listings Hit a Record High

In recent years, Chinese tourists have demonstrated a rising preference for premium dining experiences while travelling abroad. According to Meituan data, more than half of Chinese tourists opted for fine dining experiences during cross-border journeys in 2024. During the 2025 Spring Festival holiday, over 85% of Chinese domestic users browsed or searched for information on overseas Black Pearl restaurants ahead of their travels.

Chinese tourists’ growing appetite for elevated dining experiences highlights the increasing importance of the Black Pearl Restaurant Guide as a trusted reference for cross-border culinary exploration. For instance, daily average online visits to Bangkok’s Black Pearl listings surged by 27% week-on-week in the lead-up to the May Day holiday.

Southeast Asian restaurants featured in the Black Pearl have flourished amid rising demand. Le Du, a celebrated modern Thai fine dining establishment, has proudly retained its 1-Diamond rating in the Black Pearl Guide for two consecutive years. Chef Thitid “Ton” Tassanakajohn shared that Chinese guests now make up 20% of the restaurant’s clientele, with this figure continuing to grow. Similarly, Potong, a Thai-Chinese fusion restaurant nestled in the heart of Bangkok’s Chinatown, earned its first 1-Diamond rating this year. Chef and founder Pichaya “Pam” Soontornyanakij described the accolade as a significant milestone for cross-cultural cuisine and shared her excitement for welcoming more Chinese diners to experience Potong’s unique offerings.

A Powerful Catalyst for Global Culinary and Cultural Exchange

The Black Pearl has evolved beyond a ranking system into a platform for fostering global culinary and cultural exchange. Its annual “Food Vision Summit”—a global culinary exchange platform held every summer—aims to promote collaboration and dialogue between Chinese and international chefs. Chef Ton described the summit as a window into China’s increasingly globalized and open-minded culinary market, where innovative techniques are warmly embraced. “Chinese cuisine is one of the world’s finest, yet globally, awareness of high-end, refined Chinese restaurants remains limited. However, I believe this is changing,” he remarked.

Les Amis, one of Singapore’s most established French fine dining restaurants, has been awarded 3-Diamond rating in the 2025 Black Pearl Restaurant Guide. “Over the years, we’ve grown to really respect the guide — not just for its credibility, but for the cultural perspective it brings to the dining world. We love that it continues to grow its reach and push culinary standards, not just in China, but globally. It’s also given us new ideas in how we run things — like hiring team members who speak Chinese.” shared Chef Sébastien Lepinoy.

Data-Driven Insights and Culinary Expertise Propel the Black Pearl’s Global Ascent

The Black Pearl Restaurant Guide follows a rigorous selection process that combines expert evaluations, anonymous visits by judges, and big data from Meituan and Dianping to ensure fairness and accuracy. Over 77% of the judging panel is made up of gourmand enthusiasts, with annual rotations to maintain fresh perspectives. Looking ahead, the guide plans to integrate AI technology with committee nominations, blending human expertise with intelligent systems to make the discovery of exceptional restaurants around the world even more effortless.

After 15 years of remarkable growth, Meituan today connects merchants across over 170 countries and nearly 1,000 cities worldwide, offering a comprehensive ranking system spanning food, hotel, transportation, and travel. Wei Wei emphasized that as Meituan continues to expand its global footprint and as more Chinese culinary brands earn growing recognition among international audiences, the company’s ranking products are gaining increasing prestige in new markets. This growing momentum underscores Meituan’s broader vision to bridge global food cultures through innovation and champion the digital transformation of the dining industry, both within China and across the world.

To explore more international restaurants featured in the Black Pearl Restaurant Guide 2025, please click the link below to view the full list: https://drive.google.com/file/d/1jE9VapAvuM_loFkxgR_FHO6FWd5GJzY7/view?usp=sharing

About Meituan

Meituan (HKG: 3690) is a leading technology-driven retail company in China. With the mission of “We help people eat better, live better,” the Company uses technology to connect consumers and merchants. Service offerings on its platform address people’s daily needs for food and retail goods and extend further to broad lifestyle and travel services. Meituan is the world’s leading on-demand food delivery service provider and China’s leading e-commerce platform for in-store dining services. Meituan helps consumers discover merchant information, make informed decisions, complete online and offline transactions and enjoy on-demand delivery.

About Black Pearl Restaurant Guide

The Black Pearl Restaurant Guide is a prestigious dining guide selected by food enthusiasts, culinary experts, and gastronomy researchers. Anonymous judges evaluate based on culinary presentation,service and environment, and heritage and innovation. Restaurants are ranked into three diamond levels, with three diamonds being the highest. The guide celebrates exquisite cuisine through the “Chinese palate,” reflecting Meituan’s mission: “We help people eat better, live better.”

Gunbound Rises Again – 2nd Closed Beta Goes Live for Latin America and Southeast Asia

SINGAPORE, April 28, 2025 /PRNewswire/ — Gravity Game Hub (GGH) PTE. LTD., a subsidiary of GRAVITY Co., Ltd. (NasdaqGM: GRVY), is thrilled to announce the Second Closed Beta Test (CBT 2) for the legendary artillery game, Gunbound. Following the excitement of the first CBT, the second round is set to launch from [April 28 to May 07, 2025], reigniting the passion of fans across Latin America and Southeast Asia

Gravity Game Hub Launches 2nd Closed Beta Test for Gunbound
Gravity Game Hub Launches 2nd Closed Beta Test for Gunbound

Gunbound, beloved for its strategic gameplay and deep customization options, invites both returning and new players to experience fresh updates, competitive challenges, and exclusive CBT 2 rewards.

“We were overwhelmed by the response from our community during the first CBT. For CBT 2, we’ve focused on refining gameplay and fixing key issues to bring the ultimate Gunbound experience closer to launch,” said Harry Choi, President of Gravity Game Hub (GGH).

What to Expect in the Second Closed Beta Test?

CBT 2 brings further improvements and exciting new content, including:

  • Enhanced stability and gameplay balancing based on player feedback from the first CBT.
  • More diverse mobile selections and avatar customization options.
  • Jewel Fortune Box, An opportunity to test your luck and obtain exclusive rewards

Exclusive Rewards and Events During CBT 2

Players joining CBT 2 can look forward to even more engaging rewards and community events:

  • Pre Top-up Rebate Event, Earn rewards with every top-up made during this period.
  • Treasure Key, Log in via the website to obtain a Gunbound Key equivalent 50$

Note: All progress, items, and characters from CBT 2 will be RESET before the official launch.

How to Participate in Gunbound CBT 2

Joining is easy! Just follow the steps below:

  1. Visit gunboundggh.com for Account Registration
  2. Download the latest CBT 2 client from the official website.
  3. Log in and start playing with your GGH account during the CBT 2 period.

Stay Connected for Updates

Get the latest news, patch notes, and community events through our official channels:

About Gravity Game Hub

Established in 2021, Gravity Game Hub (GGH) Pte. Ltd. is a game publisher and developer focusing on online and mobile games. Gravity Game Hub is committed to delivering an interactive gaming experience and creating a dynamic community for all players in Southeast Asia.

About Softnyx

Founded in April 2001, Softnyx has spent the past 20 years releasing a diverse range of online games, including Gunbound, Rakion, and WolfTeam. The company has established a unique gaming world enjoyed by 50 million users across 60 countries worldwide. As a pioneer in the Latin American gaming market, Softnyx has sparked the Korean wave through its relentless spirit of challenge and innovation, solidifying its status as a global gaming company.

 

Vang Vieng Goes Green with New Waste System

Vang Vieng Goes Green with New Waste System
(photo supplied)

The Global Green Growth Institute (GGGI) and Laos’ Ministry of Natural Resources and Environment officially concluded the ASEAN Municipal Solid Waste Management Enhancement (AMUSE) Project on April 25 after two years of work. The project introduced innovative solutions to tackle waste challenges across the city.

Tencent Cloud Big Data-WeData: An Integrated Data + AI Intelligent Platform

Introduction: An Integrated Solution to Address Challenges in Digital Transformation

SHENZHEN, China, April 28, 2025 /PRNewswire/ — In the era where LLM driven intelligence prevails, enterprise data platforms face emerging challenges from LLM application and AI development. To name a few, efficiency loss owing to segmented AI/Data development process, data governance for heterogeneous data, traditional architecture that struggles to meet the needs for real-time data and rapid AI integration. Tencent Cloud WeData addresses these complexities through flexible architecture and product innovation, presenting an integrated data intelligence platform for enterprises to navigate these challenges and prosper in the age of AI.

4 Unique Aspects of the Integrated Data+AI Solution

 1. Unified Lakehouse, Stream-Batch Integrated Engine Engines to Enhance Storage and Compute Efficiency
  • Unified Storage Layer: A unified Lakehouse storage system with a centralized catalog service that supports structured/unstructured data and model assets, enablingcross-engine queries .
  • Unified Compute Layer: A serverless resource pool to integrate frameworks like Spark, Flink, and PyTorch, improving CPU/GPU resource utilization by 30%.
  • Integrated Streaming-Batch-Lakehouse Engine: The Setats engine dynamically switches between streaming, batch, and incremental compute modes, merging real-time states with lake storage to reduce storage costs by 50%.
 2. Holistic Data Catalog to Facilitate Collaboration and Data Circulation
  • Unified Catalog: A centralized catalog to manage structured/unstructured data, enabling seamless access across compute engines (Spark, Flink) and AI frameworks (TensorFlow, PyTorch).
  • Global Asset View: Integration of metadata for tables, volumes, models, and applications, supporting semantic search across all assets.
  • Federated Permissions: One single authorization to grant data access across engines like Spark and Ti-One, reducing policy propagation time from hours to minutes.
  • Intelligent Semantic Enhancement: Leverages LLMs to auto-generate data description, perform intelligent asset classification and maintenance, and improve documentation completeness by 80%.
 3. Integrated Development and Governance: From Manual Maintenance to Autonomous Governance

Built on the OneOps philosophy, our solution combines DataOps and AIOps to deliver three key capabilities:

  • Full-Lifecycle Standardization: Automates enterprise CI/CD pipelines for end-to-end management of data and models.
  • End-to-End Observability: Automatically captures lineage from raw inputs to AI model outputs, enabling rapid root-cause analysis, change impact assessment, real-time monitoring, and audit logging.
  • Governance-by-Design: Embeds standardized development practices, AI-oriented data modeling, and enterprise semantic layers to systematically accumulate digital assets.
 4. Unified Data and AI Security: From Compliance to AI Safety

Ensures security across the entire lifecycle—data preparation, model training, and LLM applications:

  • Data Security: Global access control, intelligent data classification/categorization, sensitive data masking/encryption, and audit trails.
  • Model Security: Detects and defends against adversarial sample attacks during training; embeds watermarks to prevent model theft; blocks discriminatory/harmful AI-generated content during inference via rule engines.
  • Application Security: API protection (e.g., unauthorized access prevention) and content moderation (e.g., forgery detection, sensitive content filtering).

#Tencent Cloud Big Data #WeData

MyRepublic Launches Singapore’s First Insurance Tailored for Geeks and Collectors


SINGAPORE – Media OutReach Newswire – 28 April 2025 – MyRepublic, an award-winning fibre broadband service provider in Singapore, has launched Geek Insurance, a first-of-its-kind insurance product designed specifically for hobbyists, gamers, and collectors. This initiative, developed in collaboration with HL Assurance, addresses the growing demand for specialised protection of high-value collectibles and gaming equipment.

MyRepublic Geek Insurance
MyRepublic Geek Insurance

As interest in trading card games, figurines, and collectible merchandise continues to rise in Singapore, many enthusiasts are investing significantly in their collections. However, traditional home insurance policies often provide limited or no coverage for such items.

Geek Insurance offers a dedicated solution, focusing on coverage for collectibles, personal electronic devices, and other household contents in the home against loss, theft, and accidental damage.

Items eligible for coverage under Geek Insurance include:

  • Trading Card Games (TCGs)
  • Figurines and Toys
  • Game Collections
  • Comic Books
  • Limited-Edition Merchandise
  • Memorabilia

“At MyRepublic, we’ve long embraced geek and gamer culture as part of our brand identity. Geek Insurance is a natural extension of that commitment, offering collectors peace of mind through targeted protection,” said Lawrence Chan, Managing Director and Chief AI Officer, MyRepublic Broadband. “We recognise the value — both financial and sentimental — that collectors place on their items and aim to provide insurance that meets those unique needs. Our own team is passionate about trading card games and collectibles too, so this is something that’s close to our hearts.”

“We are proud to partner with MyRepublic to underwrite Geek Insurance and bring this innovative product to life,” said Kelvin Lim, CEO, HL Assurance. “We understand the deep passion collectors have for their hobbies, and we’ve designed this product to offer the protection and peace of mind they deserve. This collaboration allows us to address a previously underserved segment in a meaningful and innovative way.”

Geek Insurance reflects MyRepublic’s continued dedication to developing innovative solutions for niche communities. The plans, starting from $4.90 per month with up to $15,000 coverage, feature a simplified claims process, competitive premiums, and tailored benefits, empowering customers to enjoy their hobbies without the burden of potential loss or damage. The launch of Geek Insurance marks another milestone in MyRepublic’s ongoing pursuit to deliver differentiated value and service innovation.
In addition to Geek Insurance, MyRepublic is preparing to introduce a comprehensive home insurance plan aimed at individuals seeking broader coverage for their residences and personal property.

For more information on Geek Insurance and how to apply, please visit https://myrepublic.net/sg/geek-insurance/ or contact the media representative below.

Hashtag: #GeekInsurance #GeekInsurance #GeeksUseUs #GeekCulture #CardCollectors





The issuer is solely responsible for the content of this announcement.

MyRepublic Broadband Pte Ltd

MyRepublic is an award-winning telecom operator whose values lie in the future of connectivity, the next opportunity to disrupt, and innovations that will make a real difference. The provider’s priority is to redefine broadband and mobile connectivity in the markets it operates and empower customers to understand what a true modern connectivity experience can be.

Digital Edge Releases 2025 ESG Report, Reinforcing Commitment to Building a Sustainable Digital Ecosystem

EcoVadis Platinum Rating, 100% Renewable Milestone, and Green Financing Highlight a Transformative Year in Digital Infrastructure

SINGAPORE, April 28, 2025 /PRNewswire/ — Digital Edge (Singapore) Holdings Pte. Ltd. (“Digital Edge”), a leading developer and operator of sustainable, next-generation hyperscale edge data centers across Asia, and a portfolio company of Stonepeak, a leading alternative investment firm specializing in infrastructure and real assets, today announced the publication of its 2025 Environmental, Social and Governance (ESG) Report. The 2025 report showcases Digital Edge’s performance across its three ESG pillars: Respect for Resources, Respect for People & Communities, and Respect for Transparency and outlines how the company is integrating environmental stewardship and social responsibility into the development of high-performance digital infrastructure.

Key Highlights from the 2025 ESG Report include:

  • EcoVadis Platinum Rating – Awarded to Digital Edge in its first-ever submission, placing the company in the top 1% of data center organizations globally for sustainability performance.
  • 100% renewable energy achieved at EDGE1 and EDGE2 in Jakarta, Indonesia.
  • Published and achieved SQS2 sustainability score(very good) by Moody’s Ratings on their first Green Finance Framework.
  • Industry-leading PUE of 1.25 or lower achieved at two new data centers: EDGE2 (Jakarta) and SEL2 (Incheon).
  • LEED Silver Certification secured for SEL2 and on track for multiple new sites including EDGE2 (Jakarta), BOM1 (India), and TYO7 (Japan).
  • 20% of electricity sourced from renewables across the operational portfolio in 2024, with a target of 50% by 2025 and 100% by 2030.

“We are incredibly proud of the progress we’ve made over the past year in aligning our growth with our sustainability goals,” said John Freeman, Chief Executive Officer at Digital Edge. “As demand for AI, cloud, and digital services continues to accelerate, our ability to deliver low-carbon, high-efficiency infrastructure across the region is more important than ever. This ESG report reflects how we’re turning ambition into action—ensuring our platform is built for performance, resilience, and long-term positive impact.”

The report also outlines the expansion of Digital Edge’s latest greenfield data center developments, including its 300MW hyperscale campus in Navi Mumbai and the ongoing buildout of a 100MW campus in Incheon, South Korea. These projects are being developed in line with the company’s Green Finance Framework, which was rated “Very Good” (SQS2) by Moody’s Ratings in 2024.

Digital Edge continues to expand its sustainability leadership through operational innovation, responsible supply chain practices, and enhanced community engagement programs. In 2024, employees across Korea, Indonesia, the Philippines, and Singapore contributed over 250 volunteer hours toward corporate social responsibility initiatives.

Other highlights include:

  • Zero serious safety incidents and a total recordable incident rate (TRIR) of just 0.10 across all operations and construction activities.
  • 100% of operational data centers certified with ISO 27001, ISO 45001, ISO 14001, SOC 2 Type 2, and PCI DSS.
  • 83% of employees surveyed would recommend Digital Edge as a great place to work, reflecting strong engagement and culture.

“Our ESG journey is guided by action, accountability, and an unwavering belief in the role infrastructure plays in building a better future,” said Naz Ghouse, Director of ESG at Digital Edge. “Sustainability is no longer optional—it’s foundational to how we grow. Our ESG framework empowers us to deliver operational excellence while ensuring we are a positive force for people, the planet, and the broader digital economy.”

The full 2025 ESG Report is available for download at:
Digital Edge 2025 ESG Report

About Digital Edge

Headquartered in Singapore, Digital Edge is a trusted and forward-looking data center platform company, established to transform digital infrastructure in Asia. Through building and operating state-of-the-art, energy-efficient data centers rich with connectivity options, Digital Edge aims to bring new colocation and interconnect options to the Asian market, making infrastructure deployment in the region easy, efficient and economical.

Backed by leading alternative investment firm Stonepeak, Digital Edge has established itself as a market-leading pan-Asia data center platform. The company provides data center and fiber services across Asia, with a presence in Japan, Korea, India, Malaysia, Indonesia and the Philippines. You can visit the company’s website at www.digitaledgedc.com.

Fair Home: Valued Effort: Pairwork App Launches in the US to Quantify Housework

TOKYO, April 28, 2025 /PRNewswire/ — (HQ: Shinagawa-ku, Tokyo; President & CEO: Toshikazu Saito; hereinafter “mediba”), a group company of KDDI Corporation (Japanese major telecommunication company), will begin offering its “Pairwork” app to the U.S. market on April 24, 2025, marking the start of its full-scale global expansion.

Pairwork app helps couples visualize and share housework chores
Pairwork app helps couples visualize and share housework chores

Pairwork has been helping working couples divide housework chores by visualizing who did what chores, when, and how much effort was involved. With its entry into the U.S. market, the company is now moving forward with full-scale global expansion, aiming to support diverse work styles and help couples balance their work and family lives.

Background of U.S. Expansion

In the U.S., approximately 60% of families with children are dual-income, and this figure is said to be over 50%, especially for families with children under 6. As the number of dual-income housework increases, the need to clarify and efficiently share housework responsibilities grows year by year. We believe Pairwork will meet the needs of U.S. dual-income housework by providing an environment where couples can easily cooperate and visualize housework tasks and chore-sharing status on smartphones and tablets.

In particular, we expect the “hourly wage simulation function” in Pairwork to be a unique selling point in the U.S. market and offer a new standard for evaluating housework.  By comparing hourly wage equivalents of housework internationally using our data, we strive to cultivate a global understanding of the importance of shared housework, fostering a worldwide awareness of the value inherent in domestic labor.

Key Features of Pairwork app

1. Visualize and share housework chores

Various housework chores can be easily shared through the app. Clarifying chore details and increasing transparency enables a more detailed division of responsibilities, fostering a cooperative relationship between partners.

2. Easy registration of chores by simply selecting from a list of chores

You can easily register chores by simply selecting the appropriate item from the list in the app. The simple yet comprehensive list helps users record chores they might not normally notice. In addition, since new chores can be added and the list can be freely edited, each housework can create its own unique list of chores.

3. Visualization of effort status and time

The app provides a clear visual display of who did which chores and for how long. This makes it easy to see which chores are completed and identify any uneven distribution of responsibilities.

4. Visualization of contribution by setting hourly wage for labor value

The monetary value of housework, agreed upon by the couple, can be set as an hourly rate, allowing the app to display each partner’s share of housework. This clearly shows the time and effort each partner invests in housework, fostering mutual appreciation and active cooperation.

App Name

Pairwork

usage fee

Free (*Premium membership: US$4.99 /month)

Download

App Store: https://apps.apple.com/app/id6464381260 

Google Play: https://play.google.com/store/apps/details?id=jp.mediba.pairwork 

Supported
models

iOS 11.0 or higher (smartphones) Android 7.0 or higher (smartphones)

Using the U.S. launch of Pairwork as a foothold, mediba will support working couples around the world to balance work and family and create a prosperous future together.

  • About “Pairwork”

Pairwork is a housework sharing app for working couples. It supports the sharing of chores by sharing chores and visualizing the person, time, and effort involved.

App Store: https://apps.apple.com/app/id6464381260 

Google Play: https://play.google.com/store/apps/details?id=jp.mediba.pairwork 

mediba operates Japanese carrier-related services such as “Ponta Pass”,”au5G Channel”, and “au Wellness”, and also develops various media-related businesses using mediba’s capabilities such as UX/UI consulting, BPO, and off-shore development.  By providing services that support the environment in which users can access necessary information at any time via the Internet, we are working to realize mediba’s mission “HAPPY” for people.

All company names and product or service names are registered trademarks of their respective companies.

Inquiries regarding this matter
mediba Inc.
Public Relations E-mail: koho@mediba.jp

YolTech Announces First Clinical Data from Ongoing Investigator-Initiated Trial of YOLT-101, An In-Vivo Base Editing Therapy for Familial Hypercholesterolemia

SHANGHAI, April 28, 2025 /PRNewswire/ — YolTech Therapeutics Co.,Ltd, a clinical-stage in vivo gene editing company committed to pioneering the next generation of precision genetic medicines, announced promising interim clinical data from an investigator-initiated trial (IIT) of YOLT-101 (NCT06458010), and the data has been published on medRxiv. YOLT-101 is an investigational in vivo base editing therapy for the treatment of heterozygous familial hypercholesterolemia (HeFH). Clinical data demonstrate that YOLT-101 can safely and effectively reduce low-density lipoprotein cholesterol (LDL-C) levels in HeFH patients with a single administration. As a next-generation gene-editing therapy, YOLT-101 represents a breakthrough in lipid-lowering treatment – moving beyond daily pills and regular injections, and opening a new era of “one-time treatment for lifelong LDL-C reduction.”

YOLT-101 is a next-generation in vivo base-editing therapeutic independently developed by YolTech. It features the novel, proprietary adenine base editor, YolBE—specifically hpABE5—which consists of nCas9 and a newly discovered deaminase derived from Hafnia paralvei. For delivery, it utilizes a new lipid nanoparticle (LNP) formulation. Unlike traditional CRISPR/Cas9 systems that rely on inducing DNA double-strand breaks (DSBs), hpABE5 enables precise single-base editing without generating DSBs, thereby significantly reducing the risks of chromosomal abnormalities and off-target effects. Extensive preclinical studies have demonstrated its excellent genome editing safety profile.

The in vivo base-editing therapy is delivered via intravenous infusion and selectively internalized by hepatocytes, where it induces a precise nucleotide conversion within the PCSK9 gene. This targeted edit disrupts PCSK9 protein expression, leading to enhanced uptake of LDL-C by LDL receptor on hepatocyte surfaces and finally resulting in a marked reduction in plasma LDL-C levels.

Study Design of the IIT

This is an open-label clinical trial conducted in patients with HeFH. The primary objective is to evaluate the safety and tolerability of YOLT-101, while also aiming to explore preliminary efficacy and pharmacodynamics. As of March 15, 2025, a total of 6 subjects have been enrolled: 1 in the 0.2 mg/kg cohort, 2 in the 0.4 mg/kg cohort, and 3 in the 0.6 mg/kg cohort. All subjects have completed at least 24 weeks of safety follow-up, with the longest reaching 36 weeks.

Safety and Tolerability

YOLT-101 has shown good safety and tolerability. As of March 15, 2025, no serious adverse events (SAEs), dose-limiting toxicity (DLT) events, or Grade ≥3 adverse events (according to CTCAE v5.0) were observed in any dose group. All enrolled subjects are under follow-up as scheduled.

The most common treatment-related adverse event was transient infusion-related reactions (5/6, 83.3%), with a manifestation of fever that resolved within 24 hours. Mild elevations in liver enzymes (3/6, 50.0%) were reported, which emerged on Day 4-7 following administration and rapidly alleviated usually after 7 days. All these patients did not show any relevant symptoms, and their plasma bilirubin levels (important indices for liver function) remained within normal limits throughout. No clinically significant changes were observed in other laboratory parameters.

Efficacy and Pharmacodynamics

LDL-C levels demonstrated a dose-dependent reduction following administration. Baseline LDL-C was 4.9 ± 0.6 mmol/L. In the 0.4 mg/kg and 0.6 mg/kg cohorts, sustained reductions in LDL-C were observed as early as Week 1 post-administration, reaching a maximal effect by Week 4. In the 0.6 mg/kg group, mean LDL-C level decreased by around 50% through the last follow-up with acquired data compared to baseline. The subject with the greatest response showed an LDL-C level of approximately 1 mmol/L (maximal percent change from baseline over 74%), and the efficacy has sustained for over 6 months following single-dose infusion. Pharmacodynamic data showed consistent trends, with plasma PCSK9 protein levels decreasing by over 70% from baseline starting at Week 4 in the 0.6 mg/kg group (maximal individual reduction reached 87%).

Notably, all enrolled subjects in this study were HeFH patients. PCSK9-targeting therapies typically show reduced efficacy in this population compared to with general hypercholesterolemic population. This suggests that YOLT-101 may demonstrate even greater lipid-lowering potential in the general hypercholesterolemic population.

In summary, YOLT-101 exhibits favorable safety and tolerability in HeFH patients, with adverse events being mild and transient. Both pharmacodynamic (PCSK9) and efficacy (LDL-C) outcomes in the 0.4 mg/kg and 0.6 mg/kg groups showed durable, dose-dependent reductions. These results support the potential of YOLT-101 to achieve “single-dose, lifelong lipid lowering.”

“We are dedicated to revolutionizing traditional approaches to cardiovascular disease through next-generation base editing technology and groundbreaking single-dose treatment,” said Dr. Yuxuan Wu, co-founder and CEO of YolTech Therapeutics. ” Patients with heterozygous familial hypercholesterolemia (HeFH) suffer from a lifelong, genetically driven impairment in LDL-C metabolism, resulting in markedly elevated low-density lipoprotein cholesterol (LDL-C) levels from birth. This population is at exceptionally high risk for premature atherosclerotic cardiovascular diseases. Current lipid-lowering therapies rely heavily on long-term, continuous administration. However, once treatment is discontinued, LDL-C levels rebound. These regimens are frequently hindered by poor patient adherence and drug intolerance—highlighting a critical unmet need for more durable, patient-friendly therapeutic solutions. Current clinical data of YOLT-101 demonstrates a single YOLT-101 administration can lead to significant and durable reductions in LDL-C levels. By precisely editing key genes regulating LDL-C levels in the liver, YOLT-101 has the potential to be a transformative ‘one-time treatment, lifelong cure’ therapy. We look forward to further confirming its safety and efficacy in larger-scale clinical studies and conferring benefits to patients worldwide.”

About Familial Hypercholesterolemia (FH)

Familial hypercholesterolemia (FH) is caused by mutations in LDL metabolism-related genes (LDLR, APOB, PCSK9). As a result, patients with FH have markedly elevated low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). The global prevalence of FH is 1:200-1:250, affecting a total of ~34 million people worldwide.

Current FH management strategies include lifestyle modifications, lipid-lowering medications, lipoprotein apheresis, and liver transplantation. The standard of treatment involves pharmacotherapy, with most patients receiving a triple regimen of statins, ezetimibe, and PCSK9 inhibitors. However, current therapies have significant limitations including suboptimal efficacy, intolerable side effects, and poor long-term adherence. These challenges underscore the urgent need for novel, durable therapies to address the lifelong treatment burden of FH.

About YolTech

YolTech Therapeutics is a clinical-stage in vivo gene editing company committed to pioneering the next generation of precision genetic medicines. Our approach combines innovative gene editing technologies with an advanced lipid nanoparticle (LNP) delivery system, creating a versatile platform designed to address a wide range of serious diseases. Central to our mission is the development of internal capabilities, including end-to-end manufacturing, to ensure the highest standards of quality and scalability. Our lead candidate, targeting ATTR, marks a significant milestone as China’s first LNP-mediated in vivo gene editing therapy to enter clinical development. With promising early clinical outcomes, YolTech is also advancing therapies for familial hypercholesterolemia (FH) and primary hyperoxaluria type 1 (PH1). As a company dedicated to transforming the treatment landscape, YolTech continues to push the boundaries of what is possible in gene editing.

For more information, please visit: www.yoltx.com