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Experience Japan’s Stunning Autumn with Fall Foliage and Hot Springs—-Carefully selected scenic routes for those planning a Japan trip in fall 2025

Enjoy a fulfilling travel plan combining Japan’s famous fall foliage spots, soothing hot springs, and top tourist attractions. Club Tourism presents seasonal limited tours for autumn 2025.

Special feature for those considering travel to Japan in fall 2025.

TOKYO, Aug. 25, 2025 /PRNewswire/ — Club Tourism (Headquarters: Koto-Ku, Tokyo) is now offering a special lineup of seasonal tours for fall 2025, themed around “Fall Foliage × Hot Springs.”

These tours are especially popular among travelers from Western countries and are coordinated to match the best viewing times at the most scenic locations, offering the perfect combination of spectacular foliage and renowned hot springs.

Autumn in Japan is a beautiful season when vibrant red and golden leaves paint the landscapes throughout the country. Pairing this with a relaxing hot spring experience creates a truly one-of-a-kind journey for visitors.

To bring out the best of this seasonal charm, Club Tourism offers comprehensive support including foliage-peak maps, carefully selected hot spring destinations, comfortable transportation, and guided tours. Itineraries are designed with a relaxed pace to accommodate middle-aged and senior travelers.

Featured Autumn Tour Areas

Kyoto's Fall Foliage
Kyoto’s Fall Foliage

【No.1】Kyoto’s Fall Foliage

As the cultural heart of Japan, Kyoto is home to numerous famous foliage spots. Enjoy the view of the colorful valley from Tsutenkyo Bridge at Tofukuji Temple, stroll through the bamboo grove of Arashiyama blended with autumn colors, or take in the magical nighttime illumination at Kiyomizu Temple. The contrast between traditional streets and vivid leaves offers a scenery that feels like stepping into a painted scroll.

Details: https://x.gd/rMes0

Japan's Fall Foliage
Japan’s Fall Foliage

【No.2】Tohoku Region’s Fall Foliage

Surrounded by majestic nature, the Tohoku region reaches peak foliage from mid-October to early November. Highlights include the mountain views from the Zao Ropeway, the harmony of fall colors and water at Lake Towada and Oirase Gorge, and the breathtaking scenery of red and orange covering Mt. Kurikoma. What makes Tohoku special is the chance to enjoy autumn foliage peacefully in untouched natural settings.

Details: https://x.gd/TnmwT

【No.3】Nikko, Kinugawa & Kusatsu Area’s Fall Foliage

Easily accessible from Tokyo, the Nikko–Kinugawa–Kusatsu area offers a luxurious fall getaway where you can enjoy both foliage and hot springs. The vibrant colors around Kegon Falls and Lake Chuzenji are dramatic, and walking along the Kinugawa Valley or soaking in an open-air bath at Kusatsu Onsen while enjoying the autumn scenery provides the ultimate relaxation. It’s a tour where you can enjoy nature, culture, and hot springs all at once.

Details: https://x.gd/6fiCf

Want to discover more autumn foliage tours?
▶ Explore our full collection of Fall Foliage & Hot Springs Tours: https://x.gd/jBaiS

Special Campaign Now On!
¥1,000 off when you spend over ¥6,000
¥2,000 off when you spend over ¥20,000

Recommended for:

  • Those planning a trip to Japan in fall 2025
  • Those who want to enjoy not only foliage but also hot springs and cultural experiences
  • Middle-aged and senior travelers looking for a calm, crowd-free journey
  • Those who prefer the convenience of a well-organized package tour

About Club Tourism

Club Tourism is a travel agency under the Kintetsu Group with over 40 years of experience. Since 2008, we’ve welcomed travelers from all over the world. Today, we offer over 10,000 unique tour packages, and in 2024, our website became fully multilingual for easier access by travelers from both Asia and the West.

From day trips to overnight stays, from traditional festivals to hidden local gems, our tours are designed to offer an authentic experience of Japanese hospitality and culture. The tours are also carefully planned with comfort in mind, making them ideal for mature travelers.

“If you’re visiting Japan, make it a journey to remember.” Club Tourism is here to make that happen.

Company Overview
Company Name: Club Tourism International Inc.
Address: NBF Toyosu Canal Front, 5-6-52 Toyosu, Koto-ku, Tokyo
Business Scope: Domestic and international package tours, themed travel, tour planning and operation
Official Website: https://www.club-t.com/

CreatorWeek 2025 to Launch in Macao, Merging Eastern and Western Cultures Through 5-Day Business, Content, and Community Celebration

MACAO, Aug. 25, 2025 /PRNewswire/ — Macao Government Tourism Office (MGTO) and co-organizers, Branded, will host CreatorWeek Macao 2025 from October 24-28, 2025, focusing on the global creator economy, culture, entertainment, and community. The event aims to highlight Macao’s vibrant creative economy and status as a hub for cultural exchange between East and West.

Amid the rapid rise of the global creator economy and Macao’s window of opportunity, CreatorWeek Macao will unite leading Chinese and Western social media platforms, top global content creators, and celebrity guests in an annual celebration of creativity and culture. Macao, a city bridging Chinese and Western influences, is the only place in the world where major platforms such as Douyin, RedNote, and WeChat, alongside TikTok, Instagram, Facebook, and YouTube, are freely accessible. This unique openness makes Macao an ideal gateway between Chinese-speaking users and the global digital community. The event will gather senior representatives from these platforms to share insights and explore collaboration. As more international creators tap into the Chinese market, Macao’s first world-class creator event will provide a global stage for cross-cultural exchange, content co-creation, and the advancement of the creative economy.

Supported by Macao’s six integrated resort enterprises, MGM, Galaxy Macau™ Integrated Resort, Sands China Ltd., Wynn Resorts Macau, SJM Resorts, S.A., Melco Resorts & Entertainment, the event will bring together 250 international guests, including 180 key opinion leaders/creators, 50 speakers, and 20 bands. It will cover six key zones, facilitating open and inspiring exchanges through diverse approaches, including content creation, business dialogue, artistic performances, and community interaction. Invited guests include founding member of Black Eyed Peas, apl.de.ap, highest-ranking YouTube shorts creator, Alan Chikin Chow, French beatbox crew, Berywam, Fitness Influencer, Chloe Ting, YouTube content creator, Nova’s World, dancer & Youtuber, Nicole Laeno, among others.

Six zones will include a space for opening and closing events, and a dedicated business conference zone that brings together top global creators, digital entrepreneurs, and industry leaders to explore the emerging East-meets-West trends in content creation and share expert insights.. A Creator Fan Wellness zone will feature four vibrant events where star creators and instructors lead yoga, meditation, and fitness sessions, turning online engagement into real-world positive energy and meaningful connections. A fan meet-and-greet zone will offer unforgettable face-to-face experiences with favorite creators. The Creator Artist Showcase zone will present a dynamic lineup of international and local musicians, creating a cross-cultural music experience that transcends borders. The Creator Academy zone will feature leading creators and industry voices sharing creative insights.

To participate, please register free-of-charge at www.creatorweek.live and follow @visitmacao on Instagram and Facebook, and the official account of MGTO in TikTok, YouTube , Douyin and RedNote to get real-time updates on the event.

About Macao

Macao is a vibrant city known for its rich cultural heritage, world-class entertainment, and diverse culinary scene. As a premier travel destination, Macao offers a unique blend of East and West, where ancient traditions meet modern attractions. Whether you’re exploring its historic sites, enjoying its bustling nightlife, or savoring its renowned cuisine, Macao promises an unforgettable experience for every visitor.

The Florist Defying Singapore’s Economic Downturn

Floristique, a leading florist in Singapore, has defied the odds in a tough economic climate. From humble beginnings to a thriving enterprise, Floristique’s success story is a testament to resilience, innovation, and a passion for keeping bouquets affordable.

SINGAPORE, Aug. 25, 2025 /PRNewswire/ — While many local businesses face unprecedented challenges, with more companies being liquidated in the first half of 2025 than in the same period over the last five years, one local florist, Floristique, is blossoming amidst the challenging economic conditions.

A Thorny Economy for Local Businesses

The first half of 2025 has seen a significant surge in business liquidations across Singapore, with the figure hitting a five-year high. According to the latest statistics from the Ministry of Law, 187 firms were forced by the courts to wind up from January to June 2025.

This is a notable increase from 146 in the same period last year and 95 the year before. This trend reflects a troubling rise in local businesses unable to meet their financial obligations. Many of these firms, across various sectors, are struggling with the storm of rising costs, reduced consumer spending, and fierce competition, forcing them into a difficult decision to liquidate.

Taking Floristique From Seedling to Success

Amid this turbulent landscape, Floristique, a once small online business, has flourished. Standing strong since 2017, the company has grown into one of Singapore’s leading florists.

“Seeing the news about so many local businesses closing is heartbreaking. It’s a stark reminder that success is never guaranteed,” says Wendy Han, Founder of Floristique. “It reinforces our commitment to the principles that got us here: listen to your customers, manage your costs wisely, and never lose the passion that started it all.”

However, the path to success has been anything but a bed of roses. Like many local businesses, Wendy initially struggled with very low revenue and high operational costs. And a major blow came with a cyberattack on Shopify in 2019 that drained an estimated $24,000 from the business.

“That cyberattack was a soul-crushing blow. It felt like the ground had vanished from beneath our feet,” Wendy recalls. “Losing that much money was one thing, but the feeling of violation was worse.”

But she refused to be defeated. “Instead of collapsing, we chose to fight back. It forced us to become more vigilant, to diversify our payment systems, and to double down on building a secure and trustworthy platform for our customers. In hindsight, that painful lesson made us a stronger, more resilient company.”

Building on a Philosophy of Accessibility and Trust

As many businesses grapple with the rising costs of supplies and operations, they may pass costs directly to consumers. However, Wendy’s core philosophy has been to keep the beauty of flowers and handcrafted bouquets accessible to everyone.

“Our customers reward us with their loyalty because they know we are on their side,” Wendy shares. This commitment to competitively-priced bouquets, without compromising on freshness or artistry, is exactly what cultivated Floristique a loyal customer base that trusts it for all of life’s occasions.

“Flowers shouldn’t be a luxury reserved for the few. They are a universal language of love, comfort, and celebration,” Wendy explains. “My mission has always been to make that language accessible. That means meticulously optimising our supply chain, embracing technology to reduce overheads, and focusing on volume so that we can maintain fair prices.”

Today, Floristique is a solid enterprise with a growing team and even its own fleet of electric delivery vehicles providing same-day delivery. It has evolved from a simple online business to a successful revenue-making boutique, and Wendy’s fighting spirit serves as an inspiration to aspiring entrepreneurs everywhere.

#END#

About Floristique:

Brainchild of floral-enthusiast Wendy Han, Floristique specialises in floral arrangements of all types, from fresh flowers, bouquets, flower baskets and even unique floral bags to wedding floral decorations. With free flower delivery across Singapore, Floristique ensures that flowers are readily available to those who need them. Same-day deliveries are also available for orders made before 2 pm on weekdays and 12 pm on weekends. For more information, visit their website: https://www.floristique.sg/.

Experience Japan’s Stunning Autumn with Fall Foliage and Hot Springs—-Carefully selected scenic routes for those planning a Japan trip in fall 2025

Enjoy a fulfilling travel plan combining Japan’s famous fall foliage spots, soothing hot springs, and top tourist attractions. Club Tourism presents seasonal limited tours for autumn 2025.

Special feature for those considering travel to Japan in fall 2025.

TOKYO, Aug. 25, 2025 /PRNewswire/ — Club Tourism (Headquarters: Koto-Ku, Tokyo) is now offering a special lineup of seasonal tours for fall 2025, themed around “Fall Foliage × Hot Springs.”

These tours are especially popular among travelers from Western countries and are coordinated to match the best viewing times at the most scenic locations, offering the perfect combination of spectacular foliage and renowned hot springs.

Autumn in Japan is a beautiful season when vibrant red and golden leaves paint the landscapes throughout the country. Pairing this with a relaxing hot spring experience creates a truly one-of-a-kind journey for visitors.

To bring out the best of this seasonal charm, Club Tourism offers comprehensive support including foliage-peak maps, carefully selected hot spring destinations, comfortable transportation, and guided tours. Itineraries are designed with a relaxed pace to accommodate middle-aged and senior travelers.

Featured Autumn Tour Areas

Kyoto's Fall Foliage
Kyoto’s Fall Foliage

【No.1】Kyoto’s Fall Foliage

As the cultural heart of Japan, Kyoto is home to numerous famous foliage spots. Enjoy the view of the colorful valley from Tsutenkyo Bridge at Tofukuji Temple, stroll through the bamboo grove of Arashiyama blended with autumn colors, or take in the magical nighttime illumination at Kiyomizu Temple. The contrast between traditional streets and vivid leaves offers a scenery that feels like stepping into a painted scroll.

Details: https://x.gd/S8egG

Japan's Fall Foliage
Japan’s Fall Foliage

【No.2】Tohoku Region’s Fall Foliage

Surrounded by majestic nature, the Tohoku region reaches peak foliage from mid-October to early November. Highlights include the mountain views from the Zao Ropeway, the harmony of fall colors and water at Lake Towada and Oirase Gorge, and the breathtaking scenery of red and orange covering Mt. Kurikoma. What makes Tohoku special is the chance to enjoy autumn foliage peacefully in untouched natural settings.

Details: https://x.gd/ruXX2

【No.3】Nikko, Kinugawa & Kusatsu Area’s Fall Foliage

Easily accessible from Tokyo, the Nikko–Kinugawa–Kusatsu area offers a luxurious fall getaway where you can enjoy both foliage and hot springs. The vibrant colors around Kegon Falls and Lake Chuzenji are dramatic, and walking along the Kinugawa Valley or soaking in an open-air bath at Kusatsu Onsen while enjoying the autumn scenery provides the ultimate relaxation. It’s a tour where you can enjoy nature, culture, and hot springs all at once.

Details: https://x.gd/PhNWV

Want to discover more autumn foliage tours?
▶ Explore our full collection of Fall Foliage & Hot Springs Tours: https://x.gd/QOp1O

Special Campaign Now On!
¥1,000 off when you spend over ¥6,000
¥2,000 off when you spend over ¥20,000

Recommended for:

  • Those planning a trip to Japan in fall 2025
  • Those who want to enjoy not only foliage but also hot springs and cultural experiences
  • Middle-aged and senior travelers looking for a calm, crowd-free journey
  • Those who prefer the convenience of a well-organized package tour

About Club Tourism

Club Tourism is a travel agency under the Kintetsu Group with over 40 years of experience. Since 2008, we’ve welcomed travelers from all over the world. Today, we offer over 10,000 unique tour packages, and in 2024, our website became fully multilingual for easier access by travelers from both Asia and the West.

From day trips to overnight stays, from traditional festivals to hidden local gems, our tours are designed to offer an authentic experience of Japanese hospitality and culture. The tours are also carefully planned with comfort in mind, making them ideal for mature travelers.

“If you’re visiting Japan, make it a journey to remember.” Club Tourism is here to make that happen.

Company Overview
Company Name: Club Tourism International Inc.
Address: NBF Toyosu Canal Front, 5-6-52 Toyosu, Koto-ku, Tokyo
Business Scope: Domestic and international package tours, themed travel, tour planning and operation
Official Website: https://www.club-t.com/

 

ASIA’S MARITIME POWERHOUSE: MARINTEC CHINA 2025 RETURNS WITH UNPRECEDENTED SCALE

HONG KONG, Aug. 25, 2025 /PRNewswire/ — The countdown begins! With just 100 days to go, the maritime world is gearing up for the 22nd edition of Marintec China, Asia’s most influential maritime exhibition, returning to the Shanghai New International Expo Centre (SNIEC) from 2–5 December 2025.

Marintec China 100 days to go
Marintec China 100 days to go

This year’s edition is set to be the biggest and most impactful yet, featuring:

  • Over 100,000 sqm of exhibition space across 9 halls and 2 outdoor halls
  • More than 2,200 exhibiting companies
  • An expected 100,000 attendees from 100 countries and regions

With exhibition space almost sold out, the strong demand reflects the industry’s confidence and enthusiasm for reconnecting and showcasing innovation on a global stage.

Supported by senior Chinese government officials and leading maritime organisations, Marintec China remains the unshakable cornerstone of innovation, collaboration, and growth in the global maritime sector.

EVENT HIGHLIGHTS: A SHOWCASE OF INNOVATION AND INDUSTRY LEADERSHIP

Marintec China 2025 will feature a dynamic lineup of conferences and themed zones designed to spotlight the latest trends, technologies, and strategic discussions shaping the future of maritime:

Senior Maritime Forum | Kerry Hotel | 1–4 December

The official conference of Marintec China, the Senior Maritime Forum, will bring together industry leaders and decision-makers to explore the theme:
“Smart Navigation, Green Symbiosis, Convergent Innovation.”
Key sessions include:

  • Keynote Address
  • Shipbuilding & Ocean Engineering
  • Shipping & Ports
  • Marine Finance & Law
  • Marine Equipment & Technology Forum

Marintec Cruise Interiors | Hall N3, SNIEC

Returning with strong momentum, Marintec Cruise Interiors will showcase cutting-edge design and innovation in passenger vessel interiors. Located in Hall N3, it features The Deck and The Theatre for onsite conferences and networking activities.

Marintec Innovation featuring Energytec | Hall N4, SNIEC

Introducing Energytec, a new initiative focused on alternative energy sources for maritime decarbonisation. Themed “Alternative Energy Sources and Industry Chain Support,” the conference will feature:

  • Keynote Session
  • Fuels: ammonia, LNG, methanol, biofuels
  • Electrification
  • Wind and Solar
  • Nuclear Power

REGISTRATION NOW OPEN

Visitor registration is now open. Industry professionals, buyers, and maritime enthusiasts are encouraged to secure their spot early and begin planning their visit.

As part of the registration experience, attendees can now explore the Marintec China 2025 Digital Directory, a powerful online tool offering a comprehensive preview of the exhibition.

Whether you’re attending in person or virtually, the Digital Directory is your gateway to discovering the latest advancements and connecting with key players in the global maritime industry.

Register today and be part of the future of maritime innovation.

Organisers:

Marintec China is organised and managed by Informa Markets and Shanghai Society of Naval Architects & Marine Engineers (SSNAME).

Informa Markets

Informa Markets creates platforms for industries and specialist markets to trade, innovate and grow. Our portfolio is comprised of more than 550 international B2B events and brands in markets including Healthcare & Pharmaceuticals, Infrastructure, Construction & Real Estate, Fashion & Apparel, Hospitality, Food & Beverage, and Health & Nutrition, among others. We provide customers and partners around the globe with opportunities to engage, experience and do business through face-to-face exhibitions, specialist digital content and actionable data solutions. As the world’s leading exhibitions organiser, we bring a diverse range of specialist markets to life, unlocking opportunities and helping them to thrive 365 days of the year. For more information, please visit www.informamarkets.com.

Shanghai Society of Naval Architects and Marine Engineers (SSNAME)

Shanghai Society of Naval Architecture and Marine Engineers (SSNAME), founded in early 1951, is the first scientific and technological society in the field of shipbuilding and marine engineering of the People’s Republic of China. SSNAME currently has 5,000 individual members and more than 60 group members. It has 5 working Committees, 11 Specialized Committees and 3 Representative offices. As an important non-governmental scientific and technological society with high reputation and influence in the international field of shipbuilding and marine engineering, SSNAME has been committed to promoting the progress of shipbuilding and marine engineering technology and international exchanges and cooperation. SSNAME has established closely cooperative relations with 14 well-known overseas maritime engineering societies, such as SNAME, RINA, STG, JSNAOE, SNAK and so on. It is the initiator and first chairman of the Pan-Asian Association of Maritime Engineering Societies (PAAMES) and is also a member of the International Standing Committee of the World Maritime Technology Conference (WMTC). The “Xin Yixin Ship and Marine Engineering Science and Technology Innovation Award” founded by SSNAME has become an important award for scientific and technological talents. SSNAME organizes many academic exchanges, popular science and scientific and technological publication every year. For more information, please visit www.ssname.com.cn.

Lundbeck to present new data on bexicaserin at upcoming congress, highlighting long-term impact on seizure frequency in patients with rare epilepsy

  • The full results of the open label extension (OLE) of the Phase 1b/2a PACIFIC trial investigating bexicaserin for the treatment of patients with Developmental and Epileptic Encephalopathies (DEEs), will be presented for the first time at the International Epilepsy Annual Congress1
  • DEEs are the most severe rare epilepsies, characterized by drug-resistant seizures, frequent epileptic activity on EEG and developmental slowing or regression2
  • Bexicaserin, which has been granted Breakthrough Therapy designation by the FDA, demonstrated reductions in countable and total motor seizure frequency in the extension study comparable to reductions seen in the Phase 1b/2a PACIFIC trial, reinforcing durability of response and validating its progression to Phase 3 trials1
  • Additional data will be presented from the audiogenic seizure model and the GAERS absence epilepsy model, investigating sudden unexpected death in epilepsy (SUDEP), and seizure reduction respectively.3,4

VALBY, Denmark, Aug. 25, 2025 /PRNewswire/ — H. Lundbeck A/S (Lundbeck) today announced that new data regarding bexicaserin, a novel treatment under investigation for seizures associated with Developmental and Epileptic Encephalopathies (DEEs), will be presented at the 36th International Epilepsy Congress (IEC) in Lisbon, Portugal (Aug 30Sept 3).

Bexicaserin is an investigational compound that is not approved for marketing by any regulatory authority worldwide. The efficacy and safety of bexicaserin has not been established.

“Patients with DEEs represent a challenging group of rare epilepsies, with few effective approved treatment options,” said Johan Luthman, EVP and Head of Research and Development at Lundbeck. “As we are now in phase 3 trials with bexicaserin, we are optimistic about its potential. The clinical data so far suggests broad and durable anti-seizure activity across DEEs, and new preclinical data suggests modulation of the risk of sudden unexpected death in epilepsy (SUDEP). This marks a significant step forward in the potential to transform care for patients and address critical gaps in the treatment landscape.”

The full results of the open label extension (OLE) of the Phase 1b/2a PACIFIC trial will be presented. It was designed to evaluate the long-term (up to 52 weeks), safety, tolerability, and efficacy of bexicaserin in individuals with a DEE. During the OLE, a median reduction of 59.3% in countable motor seizure frequency was observed, with 55% of participants experiencing sustained reductions of ≥50% compared to baseline before the PACIFIC trial. Bexicaserin was well tolerated, with no new safety signals observed.

“I am encouraged by the 100% enrollment of eligible participants and the high completion rate of over 90% in the open-label extension study. Such high retention underscores the tolerability as well as the duration of effect of bexicaserin across developmental and epileptic encephalopathies,” said Ingrid E. Scheffer, Lead Investigator and Laureate Professor of Pediatric Neurology, The University of Melbourne and Austin Health.

Lundbeck will also showcase preclinical data in an audiogenic seizure model of SUDEP, the most common cause of premature death in children and adults with epilepsy.3,6 Bexicaserin significantly reduced seizures and respiratory arrest in the SUDEP model. Furthermore, preclinical data will be shared indicating the impact of bexicaserin on absence seizures, a type of seizure that is often more difficult to treat.4,7

Bexicaserin has entered late-stage clinical development through the global phase 3 program, DEEp, aimed at evaluating its safety, tolerability, and efficacy in the treatment of seizures in children and adults with DEEs. The DEEpSEA trial8 is currently recruiting participants with Dravet syndrome and the DEEpOCEAN trial9 is open to individuals with DEEs (including Lennox-Gastaut syndrome).  

Both trials are randomized, double-blind, placebo-controlled and open for enrollment across the North America, Europe, Asia, Australia and Latin America, with additional sites being activated on a rolling basis.

Lundbeck’s scientific presentations at IEC:

Long-term Safety, Tolerability, and Efficacy of Bexicaserin for the Treatment of Seizures in Participants With Developmental and Epileptic Encephalopathies: Primary Results of the 12-Month Phase 1b/2a PACIFIC Trial Open-Label Extension. Poster presentation, 31 August 2025; 13:45-15:15 WEST 1

Activation of Central 5-HT2C Receptors by Bexicaserin Modulates Seizures and Respiratory Arrest in a Mouse Model of SUDEP. Platform presentation, 31 August 2025; 14:30 – 15:00 WEST 3

Impact of Bexicaserin on Seizures and Interictal Spectral Power in the GAERS Absence Epilepsy Model. Poster presentation, 31 August 2025; 13:45-15:15 WEST 4

Seizure Reductions and Tolerability in Participants With Developmental and Epileptic Encephalopathies Newly Exposed to Bexicaserin: Interim Results From the Phase 1b/2a PACIFIC Open-Label Extension. Poster presentation, 1 September 2025; 13:45-15:15 WEST10

About Bexicaserin

Bexicaserin (LP352) is an oral, centrally acting 5-hydroxytryptamine 2C (5-HT2C) receptor superagonist with no engagement of the 5-HT2B and 5-HT2A receptor subtypes, potentially minimizing the risks of cardiovascular toxicity associated with nonselective serotonergic agents. Bexicaserin is being evaluated in a global Phase 3 clinical program (the DEEp Program). The FDA has granted Breakthrough Therapy designation for bexicaserin for the treatment of seizures associated with Developmental and Epileptic Encephalopathies (DEEs) for patients two years of age and older. Bexicaserin is an investigational compound that is not approved for marketing by any regulatory authority worldwide.

About the PACIFIC trial

The PACIFIC trial was a Phase 1b/2a randomized, double-blind, placebo-controlled clinical trial to assess the safety, tolerability, efficacy, and pharmacokinetics of bexicaserin in 52 participants between the ages of 12 and 65 years old with any type of DEE (Dravet syndrome, Lennox-Gastaut syndrome and DEE other) at 34 sites across the United States and Australia. Participants who had ≥4 countable motor seizures during the 28-day baseline period, while on a stable regimen of 1 to 4 concomitant antiseizure medications were included.11

Following a 28-d baseline period, study participants initiated a dose titration over a 15-day period and subsequently continued on the highest tolerated dose throughout the maintenance period of 60 days. Eligible participants were given the opportunity to enroll in a 52-week open-label extension if they completed the 75-d RCT treatment period (titration and maintenance). The OLE duration was 52 weeks and included patients with Dravet syndrome (n=3), Lennox-Gastaut syndrome (n=20) and DEE Other (n=18), who completed the PACIFIC trial (n=41).

Contacts:
Marie Petterson
Head of Media Relations, Corp. Communication
MEEP@lundbeck.com 
+45 29 82 21 82

Jens Høyer
Vice President, Head of Investor Relations
JSHR@lundbeck.com 
+45 30 83 45 01

Palle Holm Olesen
Vice President, Investor Relations
PALO@lundbeck.com 
+45 30 83 24 26

About H. Lundbeck A/S

Lundbeck is a biopharmaceutical company focusing exclusively on brain health. With more than 70 years of experience in neuroscience, we are committed to improving the lives of people with neurological and psychiatric diseases.

Brain disorders affect a large part of the world’s population, and the effects are felt throughout society. With the rapidly improving understanding of the biology of the brain, we hold ourselves accountable for advancing brain health by curiously exploring new opportunities for treatments.

As a focused innovator, we strive for our research and development programs to tackle some of the most complex neurological challenges. We develop transformative medicines targeting people for whom there are few or no treatments available, expanding into neuro-specialty and neuro-rare from our strong legacy within psychiatry and neurology.

We are committed to fighting stigma and we act to improve health equity. We strive to create long term value for our shareholders by making a positive contribution to patients, their families and society as a whole.

Lundbeck has approximately 5,700 employees in more than 50 countries and our products are available in more than 80 countries. For additional information, we encourage you to visit our corporate site www.lundbeck.com and connect with us via LinkedIn.

References:

  1. Dlugos DJ, et al. Poster presentation: International Epilepsy Congress 2025.
  2. Sheffer IE, et al. Epilepsia. 2025;00:1-10
  3. Vermudez S, et al. Platform Presentation: International Epilepsy Congress 2025.
  4. Vermudez S, et al. Poster Presentation: International Epilepsy Congress 2025.
  5. American Academy of Neurology Annual Meeting 2025. Safety, Tolerability, and Efficacy of Bexicaserin in a Cohort of Participants with Developmental and Epileptic Encephalopathies: Interim Results of a Phase 1b/2a PACIFIC Study Open-Label Extension.
  6. Donner EJ, et al. Pediatric Neurology, 2017;70:7-15
  7. Daquin G, Bonini F. Revue Neurologique, 2024;180(4):256-270
  8. https://clinicaltrials.gov/study/NCT06660394
  9. https://clinicaltrials.gov/study/NCT06719141
  10. Ngoc Minh Le et al. Poster presentation: International Epilepsy Congress 2025
  11. Kaye R, et al. Efficacy and safety of bexicaserin (LP352) in adolescent and adult participants with developmental and epileptic encephalopathies: Results of the phase 1b/2a PACIFIC study. Presented at the Annual Meeting of the American Academy of Neurology; April 13-18, 2024

Contacts:
H. Lundbeck A/S
Ottiliavej 9, 2500 Valby, Denmark
+45 3630 1311
info@lundbeck.com 

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/h–lundbeck-a-s/r/lundbeck-to-present-new-data-on-bexicaserin-at-upcoming-congress–highlighting-long-term-impact-on-s,c4222334

The following files are available for download:

https://mb.cision.com/Main/18215/4222334/3624393.pdf

Bexicaserin IEC curtain raiser Final

 

 

 

Galan Lithium Limited: SUCCESSFUL DUE DILIGENCE COMPLETED – $20M PLACEMENT TO PROCEED

Highlights:

  • All conditions in relation to the $20 million placement to Clean Elements Fund have been satisfied.
  • Due diligence undertaken by Clean Elements Fund validates the standing of Hombre Muerto West (HMW) as a world class lithium project, offering exceptional scale and grade.
  • Galan is now fully funded to complete the construction of Phase 1 at HMW (at 4ktpa LCE) with first production of lithium chloride concentrate planned during H1 2026.

PERTH, Australia, Aug. 25, 2025 /PRNewswire/ — Galan Lithium Limited (ASX: GLN) (Galan or the Company) is pleased to announce that all conditions relating to the $20 million share placement (Placement) to the Clean Elements Fund (Clean Elements) have now been completed.

The Placement, which was undertaken at a significant premium to the prevailing share price when originally announced, was subject to certain conditions including shareholder approvals (received at a General Meeting held on Friday, 22 August 2025) as well as the satisfactory completion by Clean Elements of technical and legal due diligence in respect of the Company and HMW in Argentina. 

Clean Elements has advised that all conditions to the Placement have been satisfied. As such, the Placement will now proceed to settlement, providing Galan with the funding required for the finalisation of the HMW Phase 1 construction over the remainder of the 2025 calendar year, with first production of lithium chloride concentrate scheduled for H1 2026.

Settlement will take place in two equal tranches of $10 million.  Tranche 1 settlement will occur within the next 5 business days and Tranche 2 of the Placement will settle no later than 22 November 2025, in line with the timing set out in the relevant shareholder approval.

Managing Director, Juan Pablo Vargas de la Vega, commented: “With the support of Clean Elements, Galan now has the funding certainty to complete Phase 1 construction at HMW and is firmly on track to deliver first lithium chloride concentrate production in H1 2026.

The due diligence undertaken by Clean Elements Fund has confirmed, what we at Galan already know – HMW is an exceptional lithium project, combining substantial scale and grade with execution capability that places it among the best globally.

The team at Galan remains focussed on advancing project delivery at HMW and we look forward to creating significant long-term value for shareholders as we progress towards production.”

Clean Element’s Chairman, Ofer Amir, commented:  “We are thrilled to confirm a binding and unconditional commitment to complete both tranches of the placement—an outcome that underscores strong confidence in Galan’s strategic direction.

Our specialist lithium brine adviser highlighted that HMW is the premier lithium brine resource globally. HMW’s brine is the highest grade in Argentina with the lowest impurity profile. It also contains significantly less magnesium and calcium than the levels found in the Salar de Atacama in Chile which, when combined with HMW’s high lithium grades, gives rise to the highest lithium recoveries in the lithium brine sector to date.

This exceptional resource quality enables a low-cost, evaporation process—positioning Galan to become a high-margin, globally competitive lithium producer. In our view, Galan will not just be participating in the lithium market; it will be setting a new benchmark.”

The Galan Board has authorised this release.

For further information contact:

COMPANY

MEDIA

Juan Pablo (“JP”) Vargas de la Vega

Matt Worner

Managing Director

Vector Advisors

jp@galanlithium.com.au

mworner@vectoradvisors.au

+ 61 8 9214 2150

+61 429 522 924

 

DAHON-V – a Revolutionary Bike Tech Pushing a New Frontier in Green Mobility

BEIJING, Aug. 25, 2025 /PRNewswire/ — At the “JD Cycling Festival” in Beijing, China, the silver-gray, drop-bar folding bike DAHON P18 Ultra zipped past the finish line and claimed victory with lightning speed, challenging the industry’s perception that “portability and speed cannot coexist” for folding bikes. This decisive victory not only ignited a renewed interest in folding bikes among cycling enthusiasts but also brought DAHON’s proprietary bike tech DAHON-V into the spotlight for its speed.

Champion with DAHON P18 Ultra (center) and other medalists at the “JD Cycling Festival”
Champion with DAHON P18 Ultra (center) and other medalists at the “JD Cycling Festival”

DAHON-V Bike Tech: A revolutionary leap from the lab to track

The secret behind the championship of DAHON P18 Ultra lies in its DAHON-V technology suite, a set of bicycle design and testing technologies and methods that effectively address structural shortcomings found in most bikes and boost the speed of all types of bikes. It features patented technologies like DELTECH cable and Super Downtube that enable folding bikes to achieve performance levels comparable to that of road bikes for the first time.

Unleashing Freedom of Travel: From daily commuting to casual racing

Present on the DAHON P18, the pioneering “one-bike, dual-mode” design allows riders to fold and carry a bike easily onto subways or buses when folded, and switch to a road bike structure with the drop-bar after unfolding, perfectly addressing urban cyclists’ desire for both efficiency and style. Currently, DAHON’s folding bikes equipped with this technology are in high demand, reflecting the market’s strong desire for innovative products, above and beyond just a bike! 

DAHON P18 Ultra Folding Road Bike (Left), DELTECH cable (Upper right), Super Downtube (Lower right)
DAHON P18 Ultra Folding Road Bike (Left), DELTECH cable (Upper right), Super Downtube (Lower right)

Green Promise: Where speed meets sustainability

Guided by the “dual-carbon” goals, DAHON is evolving from a manufacturer into a technology enabler. Through its “Sharing 360” patent licensing program, DAHON forms strategic alliances with industry leaders such as Golden Wheel Group and Shenyang (SYB), sharing proprietary technologies to raise industry standards.

Speed Has No Limits; Innovation Knows No Bounds

From Magellan’s 37-month circumnavigation to the Wright brothers’ invention of the first flight for mankind, humanity’s pursuit of speed has always been about expanding the boundaries of freedom.

DAHON-V embodies that same spirit for the modern age: recalibrating mechanics using steel cables and algorithms, redefining the possibilities of folding and racing, and safeguarding sustainability with lightweight and smart design.

At this moment, DAHON is racing forward at “DAHON-V” speed into a greener tomorrow. As its gears turn to the rhythm of innovation, a new chapter of efficiency, freedom, and sustainability is being written—one that the world will witness together.

Speed has no limits, and DAHON is writing a new definition to unfold a new chapter of bike tech!

For more information, please contact marketing@dahon.com

www.dahon.com
usa.dahon.com