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J.S. Held Strengthens Cross-Disciplinary Response to Artificial Intelligence (AI) Disputes

Delivering technical clarity, financial calculus, and courtroom credibility in AI-related litigation.

NEW YORK, April 9, 2026 /PRNewswire/ — J.S. Held announced today the expansion of its integrated capabilities to support clients addressing the legal, technical, and financial complexities of artificial intelligence (AI)-related disputes. This expansion comes as the firm’s Q1 AI Disputes Monitor projects a 50% rise in AI-related case filings, underscoring the growing need for specialized expertise in this fast-evolving and complex area of litigation. 

AI disputes center on the development, deployment, or impact of artificial intelligence and differ fundamentally from traditional litigation. These matters involve systems that are simultaneously technical artifacts, economic assets, and evidentiary tools, each dimension influencing the others. Unlike conventional matters where questions can be addressed in isolation, AI disputes require a unified multidisciplinary approach. J.S. Held connects technical insight, financial analysis, and litigation experience to provide comprehensive support across all phases of dispute resolution.

Why AI Disputes Demand Integrated Expertise

J.S. Held offers integrated expertise to address the unique challenges of AI-related litigation. This approach is essential due to the complex, interdependent nature of AI systems. These matters often require:

  • Technical clarity to explain how AI systems behave, including digital forensics, model versioning, and data provenance.
  • Financial calculus to quantify economic damages, assess market impact, and evaluate intellectual property value.
  • Courtroom credibility to present findings in a manner that withstands legal scrutiny across jurisdictions.

“AI disputes uniquely require integrated expertise because AI systems exist at the intersection of three inseparable domains,” said JP Brennan, Senior Managing Director at J.S. Held. “Our work focuses on helping clients understand and explain how these systems operate in real-world contexts. We apply structured forensic methods—such as system log reconstruction, prompt replay, and model version analysis—to support investigations and testimony.”

J.S. Held experts are known for a “teaching, not telling” approach to expert testimony. Rather than simply offering an opinion, they break down complex information into clear, logical explanations that judges and juries can easily follow. “AI-related disputes increasingly require a combination of financial expertise, technical understanding, and legal analysis that is clearly communicated and able to withstand courtroom scrutiny,” said James E. Malackowski, CPA, CLP, Chief Intellectual Property Officer at J.S. Held and Senior Managing Director at Ocean Tomo. “We provide economic damages assessments, intellectual property valuation, and market impact analysis that help judges and juries evaluate questions of fair use, licensing, and commercial harm.”

Experience with AI Systems Across Sectors

J.S. Held’s work with AI systems spans multiple industries and use cases. Recent engagements include: 

  • AI Risk and Governance: Designed and implemented an AI risk and controls framework for a property and casualty insurer, improving transparency, regulatory readiness, and model oversight.
  • Vendor Ecosystem Advisory: Conducted vendor benchmarking and risk assessments for third-party AI tools at a fintech company, reducing costs, improving governance, and mitigating vendor lock-in.
  • Model Validation: Independently assessed a machine-learning fraud detection model for a digital payments platform, identifying performance and bias risks and delivering recommendations to strengthen reliability and compliance.

These engagements reflect J.S. Held’s ability to scale technical insight and support clients managing the operational and regulatory implications of AI adoption and related litigation risk.

AI Copyright Litigation – Thomson Reuters v. Ross Intelligence

J.S. Held’s role in Thomson Reuters Enterprise Centre GmbH and West Publishing Corp. v. Ross Intelligence Inc. (U.S. District Court, D. Delaware, Case No. 1:20-cv-613-SB) demonstrates the firm’s ability to support litigation at the intersection of AI and intellectual property.

James E. Malackowski was engaged as a financial damages expert to assess the fourth fair use factor (market impact) in this matter involving the use of proprietary legal research content to train a generative AI system. The engagement addressed questions of licensing markets for training data, economic substitution, and the valuation of editorial content in AI development.

Executive Perspective – Scaling with Purpose

“As AI technologies continue to evolve, our clients face increasingly complex disputes that demand more than traditional expertise,” said Lee Spirer, Chief Executive Officer of J.S. Held. “We are laser-focused on building highly integrated teams that combine technical, financial, and legal insight. This approach enables us to support both in-house and outside counsel with the depth, precision, and coordination required to address the evolving demands of AI-related litigation.”

J.S. Held’s investment in cross-disciplinary capabilities reflects its long-term commitment to delivering scalable, high-impact solutions in areas where the stakes are greatest.

J.S. Held AI Disputes Monitor – Q1 2026 Update

The Q1 2026 update of the J.S. Held AI Disputes Monitor reveals a sharp rise in litigation, particularly in the insurance sector.  Multiple lawsuits filed across the United States in early 2026 indicate growing scrutiny of AI-driven decision-making in claims processing and policy coverage, particularly within property and casualty insurance.

A total of 31 AI-related lawsuits were filed in Q1, marking a 46% increase over the average quarterly rate in 2025. At this pace, 2026 is projected to exceed the previous year’s total by nearly 50 percent.

The first-quarter 2026 snapshot underscores the accelerating pace of AI-related disputes and the growing demand for expert insight into the technical, financial, and legal dimensions of algorithmic decision-making.

To explore the full set of findings, download the latest edition of the J.S. Held AI Disputes Monitor.

About J.S. Held

J.S. Held is a global consulting firm that combines technical, scientific, financial, and strategic expertise to advise clients seeking to realize value and mitigate risk. Our professionals serve as trusted advisors to organizations facing high stakes matters demanding urgent attention, staunch integrity, proven experience, clear-cut analysis, and an understanding of both tangible and intangible assets. The firm provides a comprehensive suite of services, products, and data that enable clients to navigate complex, contentious, and often catastrophic situations.

More than 1,500 professionals serve organizations across six continents, including 84% of the Global 200 Law Firms, 75% of the Forbes Top 20 Insurance Companies (90% of the NAIC Top 50 Property & Casualty Insurers), and 71% of Fortune 100 Companies.

J.S. Held, its affiliates and subsidiaries are not certified public accounting firm(s) and do not provide audit, attest, or any other public accounting services. J.S. Held is not a law firm and does not provide legal advice.  Securities offered through PM Securities, LLC, d/b/a Phoenix IB or Ocean Tomo Investments, a part of J.S. Held, member FINRA/SIPC.  All rights reserved.

Contact:

Kristi L. Stathis | Global Public Relations | +1 786 833 4864 | Kristi.Stathis@jsheld.com 

Nancy L. Lewis, MD, MBS, FACP, Named New Chief Scientific Officer for National Comprehensive Cancer Network (NCCN)

Accomplished medical research leader will oversee NCCN programs to advance clinical trials and improve the quality, effectiveness, and accessibility of cancer care.

PLYMOUTH MEETING, Pa., April 9, 2026 /PRNewswire/ — Today, the National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers devoted to patient care, research, and education—announced the selection of Nancy L. Lewis, MD, MBS, FACP, as new Chief Scientific Officer (CSO).

Nancy L. Lewis, MD, MBS, FACP, Named New Chief Scientific Officer for National Comprehensive Cancer Network (NCCN). Learn more at NCCN.org.
Nancy L. Lewis, MD, MBS, FACP, Named New Chief Scientific Officer for National Comprehensive Cancer Network (NCCN). Learn more at NCCN.org.

Dr. Lewis is an experienced biomedical researcher with expertise in clinical trials for treating solid tumors and hematologic malignancies. She most recently served as Senior Clinical Program Leader for Novartis Pharmaceuticals, after several years as an Associate Professor for various prestigious academic cancer centers. She holds degrees from Penn State University, Temple University School of Medicine, and Rutgers University. Dr. Lewis completed residency at the University of Rochester and Fellowship at Fox Chase Cancer Center—one of NCCN’s founding Member Institutions.

“This is a pivotal time for cancer research; there are many successes to build on yet so much still to do. Dr. Lewis is the perfect person to oversee the work we do to foster innovation and knowledge discovery that improves the lives of people with cancer,” said Crystal S. Denlinger, MD, CEO, NCCN. “She will be an important asset to our leadership team as she helps us ensure our research and clinical programs continue to advance outcomes in oncology around the world.”

Dr. Lewis has previously been honored with awards from some of the foremost cancer organizations across the country, including the American Association for Cancer Research (AACR), The American Society of Clinical Oncology (ASCO), and the American Cancer Society (ACS).

As CSO, Dr. Lewis will assist in the NCCN Oncology Research Program (ORP) as well as key aspects of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) and NCCN Guidelines for Patients®. She will have oversight of the NCCN Biomarkers Compendium®; NCCN Radiation Therapy Compendium™, and NCCN Imaging Appropriate Use Criteria™. Dr. Lewis will also assist with NCCN’s Continuing Medical Education Program and with relevant global and policy initiatives.

“I am thrilled to join the National Comprehensive Cancer Network and contribute to its extraordinary legacy of advancing high‑quality cancer care,” said Dr. Lewis. “I look forward to working with NCCN’s exceptional collaborators to tackle emerging challenges and drive innovative solutions that improve the lives of patients everywhere.”

Dr. Lewis will succeed Dr. Denlinger who previously held the position of CSO before becoming CEO for the organization. Dr. Lewis will assume her new role in May 2026.  

About the National Comprehensive Cancer Network
The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to defining and advancing quality, effective, equitable, and accessible cancer care and prevention so all people can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus-driven recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information.

Media Contact:
Rachel Darwin
267-622-6624
darwin@nccn.org

GenScript and Mimulus Partner to Industrialize DNA-Based Data Storage for the AI Era

The multi-year collaboration aims to scale molecular data storage infrastructure and unlock breakthrough cost efficiencies by 2030.

PISCATAWAY, N.J. and LOS ANGELES, April 9, 2026 /PRNewswire/ — GenScript Biotech Corporation, the world’s leading provider of CMOS-based DNA synthesis technologies, and Mimulus Corp, the pioneer in Molecular Archive Technology™, today announced a strategic collaboration to industrialize DNA-based data storage, a technology poised to transform how the world preserves data in the age of Artificial Intelligence.

How Molecular Data Storage Works? While the DNA technology landscape remains fragmented across writing, reading, and storage, GenScript brings capabilities across key parts of the DNA data storage value chain, including synthesis, sequencing-related technologies, and platform development.
How Molecular Data Storage Works? While the DNA technology landscape remains fragmented across writing, reading, and storage, GenScript brings capabilities across key parts of the DNA data storage value chain, including synthesis, sequencing-related technologies, and platform development.

As the AI-driven surge in global data creation accelerates exponentially, existing archival storage systems built on magnetic tape and hard drives are reaching their economic and environmental limits. The strategic partnership between GenScript and Mimulus aims to address this challenge by architecting the world’s first molecular archival storage that requires no electricity to preserve data once encoded into DNA and can store massive volumes of information for centuries.

Under the agreement, GenScript will industrialize high‑throughput DNA synthesis at scale, targeting a leap from millions to billions of oligonucleotides synthesized in parallel on a single chip. Building on its highly-validated manufacturing platform, currently capable of synthesizing 8 million oligonucleotides in parallel on a single chip, GenScript will deliver the scale, reproducibility, and validation required to make emerging applications like molecular data storage commercially viable. While the DNA technology landscape remains fragmented across writing, reading, and storage, GenScript brings capabilities across key parts of the DNA data storage value chain, including synthesis, sequencing-related technologies, and platform development. Combined with Mimulus’ proprietary Molecular Archive Technology™, this capability enables molecular data storage to transition from laboratory innovation to commercially scalable infrastructure.

“When a new category emerges, the winners are built on infrastructure,” said Sherry Shao, Rotating CEO of GenScript Biotech Corporation. “At GenScript, we believe in Scripting Possibilities – turning what was once theoretical into scalable reality. DNA-based data storage will only become a viable real-world infrastructure when synthesis can be delivered at extraordinary throughput, quality, and cost. We are building that industrial foundation to transform molecular storage from being ‘scientific promise’ into ‘global reality’.”

Mimulus Glacier Data Storage Card is replacing decaying magnetic infrastructure. By combining GenScript’s proven industrial-scale synthesis engine with Mimulus’s molecular transcoding architecture, this credit-card-sized device creates a completely off-stack and off-grid physical vault. The collaboration seeks to dramatically accelerate the cost curve of DNA-based storage and unlock economically viable archival systems for global cloud and AI workloads.

“Trying to solve a pressing 21st-century AI data problem with mid-century magnetic tape is a bit like trying to launch a rocket with a steam engine,” said Todd R. Nelson, Ph.D., Founder and Chairman of Mimulus Corp. “But this isn’t just about building a better storage device; it’s about liquidating an operational liability to fuel the AI revolution. By combining our proprietary architecture with GenScript’s unparalleled manufacturing scale, we are printing power permits. We are handing hyperscalers the exact megawatts they need to turn on their AI supercomputers today, unlocking a trillion-dollar flywheel that reshapes the economics of the cloud.”

About GenScript Biotech Corporation

Founded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop ground breaking treatments and products. As a cornerstone of the global life science ecosystem, GenScript actively collaborates with a diverse network of partners—from academic institutions to industry leaders—to co-create cutting-edge solutions that redefine service excellence. Guided by its mission to Make People and Nature Healthier Through Biotechnology, GenScript has become a trusted global partner with a team of 6,100+ employees, supporting over 200,000 customers across 100+ countries and regions, including the world’s Top 20 pharma companies. For more information: www.genscript.com

About Mimulus Corp

Mimulus Corp is a venture-backed biotechnology company architecting the world’s first economically sustainable and physically permanent archival infrastructure for the age of AI. By combining the scaling laws of the semiconductor industry with the density of synthetic biology, Mimulus solves the global archival storage crisis and liberates critical grid power for AI compute. Led by a team of serial entrepreneurs with over $7 billion in capital formation experience, Mimulus is making the future molecular. For more information: www.mimulus.co

Media Contacts:

For GenScript: Melis Inceer, Head of Integrated Communications & Content, melis.inceer@genscript.com

For Mimulus Corp: Colette Patnaude, Founder, press@mimulus.co

 

MindHYVE.ai™ and the Development Authority of LaGrange Announce Strategic Collaboration to Advance AI-Powered Workforce Development in Georgia

Partnership brings adaptive AI upskilling to Georgia’s top-ranked economic development community, targeting the region’s advanced manufacturing and industrial workforce

NEWPORT BEACH, Calif. and LAGRANGE, Ga., April 9, 2026 /PRNewswire/ — MindHYVE.ai™, Inc. and the Development Authority of LaGrange have signed a Strategic Collaboration Framework (SCF) to deploy AI-powered adaptive learning across LaGrange’s workforce ecosystem. The partnership will introduce ArthurAI™, MindHYVE’s agentic vocational learning platform, to address upskilling demands in one of the Southeast’s largest manufacturing and industrial corridors.

MindHYVE.ai™ and the Development Authority of LaGrange announce a Strategic Collaboration Framework to deploy AI-powered adaptive workforce training across Georgia's largest business park ecosystem.
MindHYVE.ai™ and the Development Authority of LaGrange announce a Strategic Collaboration Framework to deploy AI-powered adaptive workforce training across Georgia’s largest business park ecosystem.

LaGrange currently ranks as the top economic development community in Georgia, and sixth nationally for micropolitans, according to Site Selection Magazine. The region’s Georgia International Business Park (GIBP), the largest in the Southeast and fourth largest in the country, is home to more than 41 international companies across 18 countries, anchored by multiple Fortune 500 companies, including Kia and its supplier network. With a regional workforce of approximately 250,000 and over 50,000 manufacturing jobs, employers have identified a growing gap between effective training and upskilling programs and the basic technical skills required by employers in the region.

Under the framework, MindHYVE.ai™ will work with the Development Authority to deploy ArthurAI™ across employer-driven training programs, beginning with multiple pilot cohorts in the region’s advanced manufacturing and automotive supplier networks. The collaboration includes:

  • ArthurAI™ Vocational Learning Edition (VLE) — adaptive upskilling aligned to employer-identified competencies; adjusts to each worker’s learning pace, background, and role in real time, whether they’re a first-time floor operator or a seasoned technician learning a new system
  • ArthurAI™ Corporate Learning Edition (CLE) — AI-fluency training for supervisors, management, and corporate teams, delivered in partnership with the California Institute of Artificial Intelligence (CIAI)
  • The Dawn Directive™ — the California Institute of Artificial Intelligence’s (CIAI) AI literacy and fluency program, powered by MindHYVE.ai™; a 4-month, 18-course, 360-hour AI fluency certification designed for regulated industries and the industrial workforce

Making ArthurAI™ Cost-Neutral for Georgia Employers

A critical accelerator in the LaGrange deployment is Georgia’s robust workforce funding ecosystem. ArthurAI™ training programs are designed to qualify for stacked funding through WIOA Title I (Workforce Innovation and Opportunity Act), the Georgia Work Ready credential framework, federal manufacturing training grants administered through the Department of Labor, and Economic Development partnership opportunities through the Technical College System of Georgia. For participating employers, this funding architecture has the potential to make ArthurAI™ deployment significantly more accessible. The Development Authority of LaGrange will serve as the funding coordination gateway for GIBP employers entering the program.

Initial deployment will focus on parallel pilot programs with local advanced manufacturing and automotive suppliers, comparing adaptive AI-driven training against traditional methods across metrics including completion time, competency retention, and employer satisfaction. The partnership also establishes a pathway for phased expansion across LaGrange’s diversified industrial base, with the Development Authority serving as the deployment gateway for ArthurAI™ across GIBP’s full 100+ company ecosystem.

“Workforce development has to meet people where they are, not where a standard curriculum assumes they should be,” said Bill Faruki, Founder and CEO of MindHYVE.ai™. “ArthurAI™ adapts to each learner’s background and pace, whether they’re a first-time manufacturing worker or a seasoned operator learning a new system. LaGrange’s employer base and economic development leadership make it an ideal environment to demonstrate what that looks like at scale.”

“I built ArthurAI™ on one non-negotiable principle: AI should make workers more valuable, not more vulnerable,” Faruki added. “We don’t deploy technology that displaces people — we deploy technology that makes them indispensable. If it doesn’t grow employment, we don’t ship it. LaGrange will be the proof point.”

“The Development Authority of LaGrange is committed to ensuring our workforce keeps pace with the industries that drive our economy,” said Scott Malone, President of the Development Authority of LaGrange. “This collaboration gives us a new tool to deliver training that’s faster, more personalized, and directly aligned to what our employers need.”

“We are a community built for industry, powered by talent and proven by results. We are excited to be positioned to continue leading the State of Georgia in deployment of new training technologies in ethical AI,” said Kelley Bush, Director of Workforce Development and Existing Industry for the Development Authority of LaGrange.

About the Development Authority of LaGrange

The Development Authority of LaGrange drives economic growth and business investment in LaGrange, Georgia and Troup County. Home to the Georgia International Business Park — the largest in the Southeast — LaGrange supports over 100 manufacturers, 41 international companies across 18 countries, and a regional workforce of approximately 250,000. The Authority provides strategic oversight, site selection, workforce training coordination, and business expansion support, and ranks as the #1 economic development community in Georgia and sixth nationally for micropolitans (Site Selection Magazine).

About the California Institute of Artificial Intelligence (CIAI)

The California Institute of Artificial Intelligence is the credentialing body behind the Dawn Directive™ — a 4-month, 18-course, 360-hour AI fluency certification framework designed to produce AI-fluent professionals across regulated industries including manufacturing, healthcare, finance, and law. The Dawn Directive™ is powered by MindHYVE.ai™’s ArthurAI™ platform and is deployed across institutional and employer partnerships in the United States and internationally.

About MindHYVE.ai™

Founded by Bill Faruki, MindHYVE.ai™ engineers domain-specific agentic AI systems for education, healthcare, law, finance, and governance. Its technology stack is powered by Eve-Fusion™, a proprietary multi-model consensus reasoning engine, and deployed on Eve-Grid™, MindHYVE’s enterprise-grade Azure-native cloud infrastructure. The company’s flagship platforms include ArthurAI™ for adaptive learning and ChironAI™ for clinical decision support, with deployments spanning North America, Asia, and Africa. MindHYVE does not use client data for model training; all training relies exclusively on synthetically generated data through Eve-Genesis™, its proprietary reasoning training framework. MindHYVE.ai™ is committed to the principle that AI adoption should grow employment, not diminish it.

For more information:
Website: www.mindhyve.ai  |  Email: hello@mindhyve.io  |  Phone: +1 (949) 200-8668

Partnership & Investment Inquiries:
James Barry  |  james.barry@mindhyve.io

Media Contact:
Marc Ortiz  |  marc.ortiz@mindhyve.io

DualityBio Announces China NMPA Acceptance of Biologics License Application Seeking Approval for Trastuzumab Pamirtecan for the Treatment of Unresectable or Metastatic HER2-Positive Adult Breast Cancer

SHANGHAI, April 9, 2026 /PRNewswire/ — DualityBio (“DualityBio” or the “Company”, Stock Code: 9606.HK) today announced that the Biologics License Application (BLA) for the investigational antibody-drug conjugate (“ADC”) trastuzumab pamirtecan (“T-Pam”, also known as DB-1303 or BNT323), has been accepted for review by the China National Medical Products Administration (NMPA). With the BLA filing, DualityBio is seeking approval for trastuzumab pamirtecan as second-line treatment for patients with unresectable or metastatic HER2-positive breast cancer. The application is based on positive interim results from the pivotal Phase III clinical trial (Study DB-1303-O-3001).

The DB-1303-O-3001 trial is a randomized, controlled, open-label, multicenter Phase III clinical trial conducted in China. It aims to evaluate the efficacy and safety of trastuzumab pamirtecan compared to trastuzumab emtansine (T-DM1) in patients with HER2-positive unresectable or metastatic breast cancer who have previously received trastuzumab and taxane chemotherapy. As assessed by the Independent Data Monitoring Committee (IDMC), the trial has met its primary endpoint of statistically significant improvement of progression-free survival (PFS, assessed by Blinded Independent Central Review, BICR) for trastuzumab pamirtecan compared to T-DM1 at a pre-specified interim analysis.  

Dr. Hua Mu, Global Chief Medical Officer of DualityBio, stated: “China has over 350,000 new breast cancer cases annually [1], representing a high incidence rate and ranking as the second most common cancer among Chinese women. We are delighted to see that DB-1303/T-Pam has achieved a milestone in its commercialization progress, demonstrating its potential to provide an effective new treatment option for breast cancer patients. In the China market, we have entered into a collaboration with 3SBio to jointly advance the commercialization of multiple indications of DB-1303/T-Pam in Chinese mainland, Hong Kong and Macao. Globally, we will continue to deepen our global strategic partnership with BioNTech to further drive the global development of this product. DB-1303/T-Pam is a globally co-developed new drug with strong strategic partners in both China and global markets. We will work closely together to accelerate the product’s marketing approval process, maximize its global clinical value, present more treatment options to patients worldwide.”

[1]Global Cancer,2022

About trastuzumab pamirtecan (BNT323/DB-1303)

Trastuzumab pamirtecan (“T-Pam”, also known as BNT323 or DB-1303) is a third-generation topoisomerase-1 inhibitor-based ADC targeting HER2 which is being developed by BioNTech and DualityBio. Trastuzumab pamirtecan was built from DualityBio’s proprietary Duality Immune Toxin Antibody Conjugates (“DITAC”) platform. HER2 is a surface-expressed protein on solid tumors and has been linked to the aggressive growth and spread of cancer cells, making it a potential target for innovative cancer therapeutics. The candidate has exhibited antitumor activity in both HER2-positive and HER2-low tumor models as well as in several solid tumor indications, including patients with breast and endometrial cancers, as well as other advanced solid tumors. Preclinical data and preliminary clinical data for trastuzumab pamirtecan indicate its potential to target HER2 receptors on solid tumors irrespective of expression level with a manageable safety profile and a potentially expanded therapeutic window. Trastuzumab pamirtecan is currently being evaluated in multiple solid tumor types and innovative treatment combinations, including two global pivotal clinical trials in first-line HER2-low, hormone receptor positive (“HR+”) metastatic breast cancer (DYNASTY-Breast02; NCT06018337) and second-line endometrial cancer (BNT323-01; NCT06340568), a novel-novel combination Phase 1/2 clinical trial (BNT323-03; NCT06827236) evaluating trastuzumab pamirtecan in combination with pumitamig in HR-positive or –negative, HER2-low, -ultra-low, or -null advanced/metastatic breast cancer and a Phase III, randomized, multi-site, open-label trial of BNT323/DB-1303 Versus Investigator’s Choice of Chemotherapy in Previously Treated Patients With HER2- Expressing Recurrent Endometrial Cancer (NCT06340568) .

The BNT323/DB-1303 program received the Fast Track designation and Breakthrough Therapy designation from the U.S. Food and Drug Administration (“FDA”) for the treatment of endometrial cancer in 2023.

About DualityBio

Duality Biotherapeutics (HKEX:09606) is a clinical-stage biotech company dedicated to the discovery and development of next-generation ADCs to treat cancer and autoimmune diseases. DualityBio has successfully built several cutting-edge ADC technology platforms with global intellectual property rights. Leveraging a robust pipeline, DualityBio is conducting multiple global clinical trials across 17 countries and has enrolled over 3,200 patients for multiple clinical-stage ADC candidates.

Additionally, DualityBio has established strategic collaborations with global MNCs and leading biotech innovators. As a global ADC powerhouse, DualityBio is developing novel ADCs, including bispecific ADC candidates, novel-payload ADC candidates, and autoimmune ADC candidates.

For more information, please visit www.dualitybiologics.com

Terra Quantum AG to go public in $3.25 billion SPAC deal

Strategic go-public transaction aims to accelerate growth in quantum technologies and expand global market reach

ST. GALLEN, Switzerland and INCLINE VILLAGE, Nev. , April 9, 2026 /PRNewswire/ — Terra Quantum AG (“Terra Quantum”), a leading quantum technology company, and Mountain Lake Acquisition Corp. II (“MLAC II”) (Nasdaq: MLAA), a special purpose acquisition company, today announced that they have signed a non-binding letter of intent (“LOI”) to enter into a business combination that values Terra Quantum at $3.25 billion.

Terra_Quantum
Terra_Quantum

The proposed transaction reflects strong confidence in Terra Quantum’s differentiated quantum algorithms, software, quantum security, and hybrid quantum-classical solutions, as well as its commercial traction across multiple industries including defence, finance, pharmaceuticals, and logistics.

Upon completion of the transaction, the combined entity will be publicly listed, providing Terra Quantum with enhanced access to capital markets to support its next phase of growth, including product development, global expansion, and strategic acquisitions.

Strategic Rationale

The contemplated business combination is expected to enable Terra Quantum to:

  • Accelerate the commercialization of ready to deploy quantum technologies
  • Strengthen its balance sheet to support scaling operations globally
  • Expand partnerships with enterprise and government customers
  • Enhance visibility in the quantum computing sector

Management Commentary

“This milestone marks a significant step forward in Terra Quantum’s mission to deliver practical quantum solutions on a global scale today,” said Markus Pflitsch, Chairman & Chief Executive Officer of Terra Quantum AG. “Partnering with MLAC II would enable us to accelerate innovation, deepen customer engagement, and expand our global footprint.”

Paul Grinberg, Chairman and Chief Executive Officer of MLAC II, added: “We believe Terra Quantum is uniquely positioned at the forefront of the quantum revolution which also has a management team with distinguished backgrounds in both science and the commercialisation of technology. This proposed transaction aligns with our strategy to partner with high-growth, category-defining technology companies that can create significant value.”

Advisors

Cohen & Company Capital Markets, a division of Cohen & Company Securities, LLC, is serving as exclusive financial and capital markets advisor to Terra Quantum. Heussen Rechtsanwaltsgesellschaft mbH, together with Kellerhals Carrard, Winston & Strawn, LLP, and Niedermann Rechtsanwälte, are serving as legal counsel to Terra Quantum.

BTIG is serving as financial and capital markets advisor to MLAC II. Lowenstein Sandler LLP and Lenz & Staehelin are serving as legal counsel to MLAC II.

About Terra Quantum AG

Terra Quantum AG is a leading quantum technology company focused on developing cutting-edge quantum algorithms, software, and hybrid solutions designed to solve real-world problems. Headquartered in St. Gallen, the company partners with enterprises and institutions worldwide to unlock the power of quantum computing today.

About Mountain Lake Acquisition Corp. II

Mountain Lake Acquisition Corp. II (Nasdaq: MLAA) is a blank check company formed for the purpose of effecting a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses focused on partnering with innovative, high-growth companies across technology sectors. MLAC II’s management team is led by Paul Grinberg, its Chairman & CEO, and Douglas Horlick, its Chief Financial Officer, Director, and President.

Media Contacts

Terra Quantum AG
Victoria Jodl
Global Head of Communications | Director
E-Mail: vj@terraquantum.swiss
Phone: +41 79 8131588

MLAC II
Douglas Horlick
Email: doug@mountainlakeacquisition.com

DISCLAIMERS

Additional Information and Where to Find It

If a definitive agreement is entered into in connection with the proposed business combination, MLAA or a newly formed holding company will prepare and file a registration statement on Form S-4 or Form F-4, including a preliminary proxy statement/prospectus (the “Proxy Statement”) with the U.S. Securities and Exchange Commission (the “SEC”). MLAA urges investors and securityholders to read the proxy statement/prospectus and other documents filed with the SEC when they become available, as they will contain important information regarding the proposed business combination. The Proxy Statement will be distributed to holders of MLAA’s Class A Ordinary Shares in connection with MLAA’s solicitation of proxies for the vote by MLAA’s shareholders with respect to the proposed business combination and other matters as will described therein. All SEC filings will be available free of charge at www.sec.go, v, or by directing a request to: Mountain Lake Acquisition Corp. II, 930 Tahoe Blvd STE 802 PMB 45, Incline Village, NV 89451; phone number: +1 (775) 204-1489.

Participants in the Solicitation

MLAC II and Terra Quantum  and each of their directors and executive officers may be considered participants in the solicitation of proxies with respect to the proposed transaction under the rules of the SEC. Information about the directors and executive officers of MLAC II and a description of their interests in MLAC II and the proposed transaction is contained in MLAC II’s Annual Report on Form 10-K for the year ended December 31, 2025, which was filed with the SEC on March 20, 2026 (the “Annual Report”).

Information about MLAC II’s directors and executive officer’s interests in the proposed transaction, as well as information about Terra Quantum’s directors and executive officers and a description of their interests in Terra Quantum and the proposed transaction will be set forth in the Proxy Statement relating to the proposed transaction when it is filed with the SEC. When available, the above referenced documents can be obtained free of charge from the sources indicated above.

Forward-Looking Statements

This document contains certain forward-looking statements within the meaning of the federal securities laws with respect to the proposed business combination between MLAC II and Terra Quantum, including statements regarding the benefits of the proposed business combination, the anticipated timing of the proposed business combination, the products being developed by Terra Quantum and the markets in which Terra Quantum intends to operate, business strategies, debt levels, industry environment, potential growth opportunities and the effects of regulations. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “forecast,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” “positions,” “enables” and similar expressions (including the negative versions of such words or expressions). 

Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this document, including but not limited to: (i) the risk that the proposed business combination may not be completed in a timely manner or at all, which may adversely affect the price of MLAC II’s securities; (ii) the risk that the proposed business combination may not be completed by MLAC II’s business combination deadline and the potential failure to obtain an extension of the business combination deadline; (iii) the failure to satisfy the conditions to the consummation of the proposed business combination, including the approval of the proposed business combination by the shareholders of MLAC II or Terra Quantum, and the receipt of certain governmental and regulatory approvals; (iv) the effect of the announcement or pendency of the proposed business combination on Terra Quantum’s business relationships, performance and business generally; (v) risks that the proposed business combination disrupts current plans of Terra Quantum; (vi) the outcome of any legal proceedings that may be instituted against MLAC II, Terra Quantum or related to the agreement and plan of merger or the proposed business combination; (vii) the ability to maintain the listing of MLAC II’s securities on NASDAQ; (viii) the price of MLAC II’s securities, including volatility resulting from changes in the competitive and highly regulated industries in which Terra Quantum plans to operate, variations in performance across competitors, changes in laws and regulations affecting Terra Quantum’s business and changes in the combined capital structure; (ix) the ability to implement business plans, forecasts and other expectations after the completion of the proposed business combination, and identify and realize additional opportunities; and (xi) the impact global economic and political conditions, including the Russia-Ukraine conflict. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in MLAC II’s Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and other documents filed from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and MLAC II and Terra Quantum assume no obligation and, except as required by law, do not intend to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise. Neither MLAC II nor Terra Quantum gives any assurance that either MLAC II or Terra Quantum will achieve its expectations.

No Offer or Solicitation

This press release is not a proxy statement or solicitation of a proxy, consent or authorization with respect to any securities or in respect of the potential transaction and shall not constitute an offer to sell or a solicitation of an offer to buy the securities of Terra Quantum, MLAC II or the combined company, nor shall there be any sale of any such securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such state or jurisdiction. No offer of securities shall be made except by means of a prospectus meeting the requirements of the Securities Act of 1934, as amended.

Cautionary Note Regarding the Proposed Transaction

Completion of the proposed transaction is subject to the negotiation of a definitive agreement and the satisfaction of conditions contained therein. The parties will announce additional details regarding the proposed business combination if and when a definitive agreement is executed. Accordingly, there can be no assurance that a definitive agreement will be entered into or that the proposed transaction will be consummated or, if a transaction is consummated, as to its terms, structure or timing. Any transaction would be subject to the completion of satisfactory due diligence, negotiation of definitive agreements, board and shareholder approvals, regulatory approvals, and other customary conditions.

 

Businesses face sustained pressure in 2026 as global insolvencies rise 3%, Atradius forecasts

AMSTERDAM, April 9, 2026 /PRNewswire/ — Atradius forecasts a further rise in insolvencies in 2026, as adverse conditions continue to weigh on companies, affecting operating margins across multiple sectors. The latest Atradius Insolvency Outlook shows that worldwide insolvencies are expected to increase by 3% in 2026.

According to Atradius Senior Economist Theo Smid, “Our insolvency forecast has deteriorated due to the persistence of adverse economic conditions, including Covid‑related tax debts, rising input costs and ongoing trade tensions. The crisis in the Middle East, together with the associated increase in energy prices, adds to existing pressures. The impact on businesses will depend largely on the length of the conflict.”

Atradius’ baseline scenario assumes that the current closure of the Strait of Hormuz will begin to normalise from May, with only limited damage to Gulf infrastructure. If the disruption lasts longer, the insolvency projections would need to be revised.

Looking further ahead, the outlook improves in 2027, when insolvencies are projected to decline by 6% as inflation recedes, energy markets normalise and central banks regain room to reduce rates.

Regional outlook

In Europe, Atradius expects the highest rise in Switzerland, Italy and Portugal, while Ireland, Denmark, Norway and the Netherlands are set for decreases. Across the eurozone, companies continue to operate under substantial pressure in 2026. Higher energy prices, driven by disruptions in gas markets linked to the conflict in the Middle East, are feeding through to broader inflation and weighing on margins.

North America remains divided. In the United States, insolvencies are forecast to rise by 8% in 2026. The economic climate remains challenging for companies, with high trade tariffs and increased policy uncertainty continuing to weigh on the operating environment. In contrast, Canada is expected to see a decline in insolvencies as filings continue to normalise following the sharp rise in 2024.

In Asia‑Pacific, most monitored markets are set for decreases as insolvencies begin to retreat from historically high levels. New Zealand and Hong Kong show the strongest downward adjustments, while Australia, Japan and South Korea are likely to normalise more slowly.

For more detailed forecasts by country and region, access the full Atradius Insolvency Outlook.

Atradius

More information at https://group.atradius.com.

Press contact
Pavel Gómez del Castillo
pavel.gomezdelcastillo@atradius.com

 

OncoC4 announces first participant’s dosing in Phase 1/2 clinical trial of ONC-841 for the treatment of Alzheimer’s disease

ROCKVILLE, Md., April 9, 2026 /PRNewswire/ — OncoC4 Inc., a late clinical stage biopharmaceutical company, today announced first participant’s dosing following the clearance of the Investigational New Drug (IND) application for a Phase 1/2 clinical trial of ONC-841, the company’s investigational Alzheimer’s disease therapy by the National Medical Product Administration (NMPA). The clinical trial registration number is CTR20260866.

ONC-841 is the world’s first and only clinical stage anti-SIGLEC 10 antibody. The drug was initially developed, and is in a Phase 2 trial, for patients with solid tumors. New preclinical research by OncoC4 has revealed ONC-841’s novel activity in normalizing microglia’s function in clearance of pathogenic protein aggregates in the brain (1, 2). Benefitting from safety data from the oncology study, the new Phase 1/2 AD clinical trial received accelerated clearance to test the safety and clinical activity of the product for AD treatment.

The first study participant was successfully dosed at Xuanwu Hospital of Capital Medical University in China. The Principal Investigators for the clinical study are Professor Yi Tang and Professor Cuibai Wei at the Xuanwu Hospital.

“Extending our clinical study from cancer to AD showcases OncoC4’s research engine and Xuanwu Hospital’s infrastructure as the world’s eminent AD research center. We are extremely grateful to our colleagues at Xuanwu for the collaboration, ” said Dr. Yang Liu, CEO and Chief Scientific Officer. 

“We are extremely excited to collaborate with OncoC4 to explore the potential of targeting SIGLEC 10, the novel checkpoints of AD pathogenesis, to bring clinical benefit for patients with this devastating illness”, added Professor Yi Tang, Executive Vice President and Principal investigator. 

About OncoC4

Based in Rockville, Maryland, OncoC4 is a privately held, late clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of novel biologicals for the treatment of cancer and immunological diseases. OncoC4’s pipeline features assets with first-in-class and best-in-class potential targeting both novel and well validated targets across oncology and immunological diseases. Among them, AI-081 is a fully owned bispecific antibody candidate targeting PD-1 and VEGF. ONC-841 is a first-in-class anti-SIGLEC 10 antibody currently in a Phase 2 trial for oncology indications and a Phase 1 trial for neurodegenerative diseases. OncoC4 has a strategic collaboration with BioNTech to co-develop gotistobart (BNT316/ONC-392), a tumor microenvironment-selective Treg depletion candidate targeting CTLA-4, in multiple solid tumor indications, including an ongoing pivotal clinical trial in squamous non-small cell lung cancer.

More information: www.oncoc4.com. 

CONTACTS

Media Relations
Pan Pan
media@oncoc4.com

Investor Relations
Ryan Cui
ir@oncoc4.com

  1. Wang P, et al. Therapeutic activities of anti-human SIGLEC 10 mAb in multiple transgenic mouse AD models. Alzheimer’s Dement. 2025, 21 (Suppl. 5): e101818.
  2. Wang P, et al. Mice carrying unmutated human SIGLEC 10 gene cluster transgene develop both amyloid plaques and Tau neurofilament tangles: a model for late onset Alzheimer’s disease. Alzheimer’s Dement. 2025, 21 (Suppl. 5): e101773.