HSINCHU, Dec. 18, 2025 /PRNewswire/ — AP Memory, a leading global design company providing customized memory solutions, today announced further advancements in its S-SiCapTM (Stack Silicon Capacitor) product line to address the increasing integration demands of AI servers and high-performance computing (HPC) systems. The S-SiCapTM portfolio includes two product categories —discrete silicon capacitors and interposers with silicon capacitors — designed to support different system architectures and diverse application requirements.
The discrete silicon capacitors, S-SiCapTM Gen4, achieves a capacitance density of 3.8 μF/mm², an increase of more than 50% over the previous generation. To meet the growing demand for higher performance and power efficiency in AI servers and HPC systems, S-SiCapTM Gen4 is the first to adopt embedded substrate packaging and is currently in the sampling and process validation stage. Mass production will be introduced progressively starting in 2026.
Meanwhile, the S-SiCapTM Interposer utilizes a silicon wafer as its substrate, embedding high-density silicon capacitors within the interposer. This significantly enhances signal integrity and power stability for high-speed I/O applications such as die-to-die, SerDes, and HBM. In collaboration with supply-chain partners, AP Memory has introduced a reticle-stitching technology to enlarge interposer die area allowing more IC chiplets to meet the growing demand for higher-integration advanced packaging solutions. The S-SiCapTM Interposer has completed customer packaging and reliability validation, entering four-reticle mass production at the end of Q3’25. Additional development projects are currently underway.
Ivan Hong, President of AP Memory, stated, “As AI and HPC applications continue to evolve rapidly, the industry is facing increasingly stringent requirements for power integrity and high-speed signal transmission. Through the S-SiCapTM product line, AP Memory delivers silicon capacitor technology in both discrete components and interposer-integrated forms, providing high performance, high integration, and design flexibility to meet the demands of next-generation AI and HPC systems.” Looking ahead, AP Memory is actively developing silicon capacitor solutions for organic interposer architectures, further expanding its product portfolio.
About AP Memory
AP Memory (TWSE: 6531) is a global fabless design semiconductor company specializing in customized memory design and IP solutions. Products include IoT memory (IoTRAMTM), AI memory solutions (VHMTM), and silicon capacitors (S-SiCapTM). With strong R&D capabilities, AP Memory is committed to providing high performance, low-power and innovative customized products and solutions for applications such as mobile communication, wearable, IoT, high-end mobile application, high-performance computing, and edge computing.
Expanded new mixed-gender team competition, Hexagon World Series will feature multiple events per year in iconic global cities with equal prize money
Series becomes the first fully FIP – governed team circuit, included into the official FIP calendar to complement existing professional and amateur events, encompassing Cupra FIP Tour and Premier Padel
This evolution represents a major opportunity for the Hexagon Cup to be fully integrated within the federative padel pyramid
Official recognition builds on strategic partnership announced in February 2025 between Hexagon Cup, Premier Padel and FIP, under which Premier Padel is also a shareholder and major strategic partner in the new series
LONDON, Dec. 18, 2025 /PRNewswire/ — Hexagon Cup, the team-based Padel tournament established in 2024 that revolutionised the sport’s international landscape, has today announced an historic strategic alliance with 54, the global sport and entertainment agency behind the creation of LIV Golf, and the game’s global governing body, International Padel Federation (FIP).
Hexagon Cup, 54 and International Padel Federation unite to create the Hexagon World Series unifying the padel calendar. (Pictured left to right: Gary Davidson – Group Chief Operating Officer, 54; Enrique Buenaventura – Founder, Hexagon Cup; Luigi Carraro – President, FIP)
Under this agreement, 54 will invest and partner with Hexagon Cup to expand and elevate the initial project into its next phase: a new global team circuit, officially named the Hexagon World Series, in what will become the first team Padel series to be delivered under the governance of FIP, fully integrated into the federative padel pyramid.
The agreement positions Hexagon World Series as the sport’s official global team circuit, governed by FIP and integrated fully into the official FIP calendar. The Hexagon World Series will expand the revolutionary team-based format of the Hexagon Cup into a series model, adding multiple events per year across new international locations. This expansion will open fresh commercial opportunities for fans, players and partners, while strengthening the overall FIP ecosystem and the Olympic dream alongside existing tours and FIP’s governance.
The new circuit will complement Premier Padel, FIP’s flagship professional tour for individual pairs, elevating Padel to a new level, whilst creating new value within a fully integrated commercial structure to sit at the top tier of the world’s fastest growing sport.
Together, Premier Padel and the Hexagon World Series will form the global professional circuit for elite players: one tour for the world’s top pairs, and one groundbreaking teambased competition, both under the governance of FIP.
Details of the new competition format, teams, calendar of events and global host cities will be unveiled in 2026.
54’s investment is also the closing of an international financing round for Hexagon Cup, backed by a diverse group of global investors. These include PadelPark India, the British operator Padel Hub, the US-based Padel operator Epic Padel, as well as investment funds and platforms such as Players Fund (United Kingdom) and LinkinFirm (Brazil), alongside other strategic partners from Mexico, Spain, the United States and the Middle East. This multi-regional capital structure reinforces the strength of the project and its position to lead the international expansion of Padel.
Enrique Buenaventura, Founder of Hexagon Cup, said: “This partnership marks a new chapter in the history of padel. Together with 54, FIP and the support of, and fantastic relationship with, Premier Padel, we will build the first truly global team circuit, expanding the vision of the Hexagon Cup and creating something never seen before in our sport. Our mission is to help grow padel worldwide, unlock new commercial opportunities, and contribute decisively to its Olympic journey.”
Luigi Carraro, President of FIP, said: “FIP’s mission is to develop and grow Padel at every level of the pyramid – from grassroots and amateur participation to elite professional – all around the world. The launch of Hexagon World Series – under the umbrella and governance of FIP and as part of our official international calendar, already including the Cupra FIP Tour and Premier Padel – further enhances, consolidates and stabilizes our ecosystem with the most prestigious competitions in the sport. Together, we will ensure Padel continues to grow with the professionalism, global visibility and collaborative structure – working with all recognized stakeholders within Padel and world sport – driving Padel’s long-term success on an international scale.”
Gary Davidson, Group Chief Operating Officer, 54, said: “Padel is one of the fastest growing sports globally, and we see an incredible opportunity to help accelerate its professionalisation and global reach. “Teaming up with Hexagon Cup and FIP to create the Hexagon World Series is a natural extension of our commitment to building the world’s most exciting sporting properties, molded through modern commercial structures and integrated into the existing ecosystem to deliver the best experiences for athletes and fans, and the best performance for partners and investors.”
SEOUL, South Korea, Dec. 18, 2025 /PRNewswire/ — Agricultural Corporation Geumsan Insamju, a Korean traditional liquor producer, is stepping up its efforts to expand into overseas markets by participating in an international expo to be held from December 25 to 29, 2025, in the Hong Kong Island and Wan Chai areas.
Geumsan County and the Geumsan Ginseng & Medicinal Herb Industry Promotion Institute are actively supporting the global expansion of Geumsan Insamju’s traditional liquor products. This initiative is part of a broader strategy launched in 2022 to localize and commercialize Geumsan ginseng for international markets. Through export consultation sessions and exhibitions in key overseas markets such as Hong Kong, Vietnam, and Malaysia, the company aims to engage with local buyers and achieve tangible export outcomes.
An official from Agricultural Corporation Geumsan Insamju stated, “Entering overseas markets is not merely about exporting products; it requires customized strategies aligned with local liquor cultures and trends.” The company plans to strengthen cooperation with local buyers to diversify global sales channels for its flagship products, including Geumseol, and other Geumsan Insamju offerings.
BEIJING, Dec. 18, 2025 /PRNewswire/ — In science fiction films, robots are portrayed as often an indispensable part of future life. They can participate in industrial production, operate in hazardous environments inaccessible to humans, and provide services spanning medical care and daily housework. Today, such scenarios are becoming a reality in China.
China Matters’ Feature: The Booming Embodied Intelligent Robots Industry
Now, an increasing number of embodied intelligent robots are working across China—on factory production lines, football pitches, marathon courses, etc. These robots come in diverse forms, including assembly robots, inspection robots, tea-brewing robots, rescue robots and humanoid robots. On the stage of the Spring Festival Gala, robots shocked the audience with traditional yangko dance and handkerchief twirling.
What makes Chinese robot industry brilliant? First comes the “body revolution.” Equipped with “super muscles”, integrated actuators, robots become stronger. They can complete a half marathon race in 2 hours and 40 minutes. Strength alone isn’t enough; coordination of limbs is essential. The “joint cartilage”—harmonic drive reducers—plays a crucial role. Domestic production of harmonic drives has reduced robot manufacturing costs by at least 30%. With the integration of DeepSeek, robots can now reason and learn, truly beginning to “think.”
In early 2025, the Yangtze River Delta and the Guangdong-Hong Kong-Macao Greater Bay Area began working together to create highly efficient supply and innovation chains. China is now shaping a “robot neighborhood” ecosystem by which a robot is designed in the morning and all its components are sourced from suppliers by the afternoon.
China has become an important contributor to shaping the future of robotics. The animation series, Xi’s Thought Made Easy by China Matters will help you better understand China’s embodied intelligent robots industry.
New breakthroughoutstrips all other silicon QPUs and demonstratesincreasing qubit qualitywith increasing qubit count:clearing the path tofault tolerant,commercial scale systems
SYDNEY, Dec. 18, 2025 /PRNewswire/ — Silicon Quantum Computing (“SQC”), a leader in quantum computing and quantum machine learning, has achieved a breakthrough that positions the company at the forefront of the silicon modality, widely viewed as the most scalable approach to quantum computing. Nature, the world’s leading multidisciplinary science journal, today published this landmark achievement: a multi-qubit, multi-register quantum processor with exceptional quality and performance that improves as the system scales.
With fidelities up to 99.99%, SCQ’s latest result sets a new milestone for the quantum computing field. Typically, when quantum systems add more qubits and become more complex, their quality declines. SQC’s architecture demonstrates the opposite: as qubit count increases, the qubit quality strengthens – a critical requirement for fault tolerant, commercial scale systems.
Building a quantum computer in silicon is a natural choice for the field. The world has already refined classical computing in silicon, and it is one of the world’s best understood elements. This material choice leverages trillions of dollars in R&D, semiconductor fabrication and wafer purification.
SQC is the only private quantum computing company that manufactures its own quantum chips (QPUs). The company’s industry-leading manufacturing process, developed over 25 years, patterns chips with 0.13 nanometer (atom level) precision, placing phosphorus atoms within pure silicon wafers. It is the most accurate semiconductor manufacturing process in the world – a demonstration of SQC’s commitment to materials purity and precision engineering, no less than what is required to deliver commercial scale quantum computing.
SQC has consistently delivered world-leading accuracy on benchmark quantum algorithms such as Grover’s. Now, with these results achieved across multiple registers, the path for scaling toward millions of qubits is clear.
SQC‘s Founder and CEO, Michelle Simmons, said:“In most quantum systems, scale comes at the cost of performance.Our systemincreases inquality as it scales, an immense achievement thatwe‘re proud to share with the world.It‘s a reflection of our careful choices in materials,architectureand modality, which puts us on track to deliver the world‘s first commercial scale quantum computer.“
SQC Chair and former ARM CEO Simon Segars, added:“Today‘s announcement illustrates the elegance and powerful simplicity of SQC‘s approach. Alongside our customers and partners,we‘re delivering value and commercial advantage in quantum computing today. I‘m proud to support a team that is both leading the field scientifically whiledelivering real-world solutions.“
Silicon Quantum Computing (“SQC”) is at the forefront of global efforts to build a commercial-scale quantum system. Leveraging over 25 years of technological excellence and delivery, SQC’s proprietary machines and processes allow the company to see and control matter atom-by-atom. SQC’s atomically engineered quantum machine learning chips and universal quantum computing systems have demonstrated world-leading algorithmic fidelity, positioning the company at the forefront of quantum innovation. Controlling its own QPU manufacturing means that SQC can design, produce and test new systems every week while delivering quantum machine learning and simulation systems to customers today. The company was founded in 2017 and is headquartered in Sydney, Australia.
LAS VEGAS, Dec. 18, 2025 /PRNewswire/ — Robotin today announced the global hands‑on debut of the Robotin R2 Pro, the world’s first fully modular robot carpet washer, vacuum, and mop. Already known to Kickstarter backers for its powerful vacuum and carpet‑washing capabilities, Robotin is surprising CES attendees with the reveal of a previously undisclosed Mopping function, now integrated into the Vacuum Module.
Robotin will showcase the R2 Pro at CES 2026, located at Venetian Expo, Eureka Park, Booth #62041 from January 6–9. Exclusive media previews will also be held at CES Unveiled (Jan 4) and Pepcom Digital Experience! (Jan 5).
Robotin R2 Pro – World’s First Robot Carpet Wash & Vacuum & Mop
This marks the first time the public can physically experience the R2 Pro’s modular design. Powered by a 3‑stage automatic carpet washing and drying system, 115 AW suction, and AI perception navigation, the R2 Pro bridges the gap between everyday vacuuming and true deep‑carpet cleaning. The newly revealed wet‑mopping capability positions the R2 Pro as an all‑floor‑type cleaning solution.
A New Standard in Home Robotics
The Robotin R2 Pro introduces a new category of modular home‑cleaning robots.
Carpet Wash & Dry Module Automatically washes, rinses, and dries carpets—a breakthrough that delivers on the company’s core Kickstarter promise.
Vacuum & Mop Module A newly confirmed innovation featuring integrated wet‑mopping for hard floors, enabling seamless transitions between floor types.
Future Expansion Robotin also teased its upcoming Robotic Arm Module, expected in 2027, highlighting the long‑term flexibility of the platform.
Core technologies include 115 AW suction, AI perception, and a self‑refilling/emptying station, which significantly reduce maintenance and operating time.
Why It Matters
The R2 Pro establishes a new benchmark for smart cleaning systems:
Creates a new category of modular AI home robots
Combines multiple devices into one flexible platform
Cleans 400 sq ft of carpet in ~3 hours with automated washing and drying
R2 Pro is an all in one solution for all surface including carpet and floor.
Supports long‑term sustainability through upgradable modules rather than full device replacement
The R2 Pro also represents a step forward in smart‑home living:
Defines the emerging “modular home cleaner” market segment
Reduces physical strain and cleaning time
Supports healthier home environments through automated deep cleaning
With its debut at CES 2026, Robotin marks a major milestone after its successful Kickstarter campaign, reinforcing its position as a pioneer in AI‑enabled household robotics.
Roadmap & Availability
CES 2026 Live Demos: Carpet Wash & Dry Module + new Vacuum & Mop Module
Commercial Release: Mid‑2026
Future Expansion: Robotic Arm Module in 2027
Smart Home Integration: Google Home, Alexa, Robotin App
Funding: Successful Kickstarter with 100+ early backers
Long‑Term Vision: A fully modular household robot serving as a comprehensive home assistant
Media Availability & Live Demos
Members of the press can experience the Robotin R2 Pro at:
Robotin is an innovative technology company focused on the research, design, production, and marketing of AI and robotics. Guided by the vision of “everyone has a robotin,” the company aims to improve everyday life through intelligent automation. Upholding the values of customer‑centered thinking, truth‑seeking, excellence, and continuous innovation, Robotin is committed to building a leading international brand in AI and robotics. Its core value proposition — “Robot in, chores out” — drives the development of next‑generation modular home robotics.
Hang Lung’s Vision for Academic Excellence Drives Hong Kong’s Global Competitiveness
HONG KONG SAR & SHANGHAI, CHINA – Media OutReach Newswire – 17 December 2025 – The winners of the 2025 Hang Lung Mathematics Awards (“HLMA”), co-organized by Hang Lung Properties Limited (SEHK Stock Code: 00101) (“Hang Lung” or the “Company”) and the Hong Kong University of Science and Technology (“HKUST”), have been announced. Siu Man Li from the Hong Kong Chinese Women’s Club College received the Gold Award for his research report titled “Markov Chains Associated with Ultraspherical Polynomials: An Analysis of Weak Convergence and First Passage Time Functionals”.
Dr. Choi Yuk-lin, Secretary for Education of the Hong Kong Special Administrative Region (left) and Professor Richard Schoen, Chair of the 2025 HLMA Scientific Committee (right) present the Gold Award to winner Siu Man Li from Hong Kong Chinese Women’s Club College at the 2025 Hang Lung Mathematics Awards.
The Silver Award and the Bronze Award were won by Augus Kui Lam Huang, Inna Belle Lee, Chun Lam Lo, Lok Hei Qiao, and Cheuk Lok Wong from St. Paul’s Co-educational College, and Edison Sze Ho Fu, Yun Tung Ko, Hoi Chun Puk, and Wai Kwan Yeung from Queen’s College, respectively. All winning teams demonstrated exceptional problem-solving abilities, creativity, and academic rigor evident in their work on challenging mathematical topics.
The awards were presented at tonight’s ceremony, celebrating the remarkable achievements of the student finalists and reaffirming HLMA’s sustained contribution to advancing STEM education in Hong Kong. In her opening remarks, Dr. Choi Yuk-lin, JP, Secretary for Education of the Hong Kong Special Administrative Region, said, “The Hang Lung Mathematics Awards not only honours mathematical endeavours, but also reflects its enduring commitment to inspiring a continued passion for mathematics among our students and nurturing Hong Kong’s young talents. This aligns well with the promotion of self-directed learning, problem solving and creativity in Hong Kong’s school education. I hope all of us in the society can join hands in the promotion of digital education and mathematical modelling for the benefit of our students.”
Mr. Adriel Chan, Chair of Hang Lung Properties, also addressed the audience, stating, “As we celebrate the winners of the Hang Lung Mathematics Awards, we are reminded that talent development is a long-term investment. HLMA embodies our commitment to nurturing the next generation of thinkers and leaders who will navigate an increasingly complex world. We are heartened by the strong support from students, schools, and the academic community, which reinforces our shared mission to advance mathematics education and push the boundaries of excellence. Together, we are empowering young minds to pursue their passion and unlock their potential in mathematics, science, and technology.”
Professor Nancy Ip, President of HKUST, said, “HKUST is pleased to continue our partnership with Hang Lung in this biennial competition. Hang Lung Mathematics Awards is more than an academic contest; it is a platform that challenges students to push the boundaries of their knowledge and apply rigorous methodology to original research. By cultivating a community of aspiring mathematicians and providing them with access to world-class training, we are advancing our shared vision of transforming Hong Kong into a global hub for innovation and technology.”
A group photo of the winning teams of the 2025 Hang Lung Mathematics Awards with Dr. Choi Yuk-lin, Secretary for Education of the Hong Kong Special Administrative Region; Mr. Ronnie C. Chan, Honorary Chair of Hang Lung Properties; Mr. Adriel Chan, Chair of Hang Lung Properties; Mr. Weber Lo, Chief Executive Officer of Hang Lung Properties; Kenneth Chiu, Chief Financial Officer of Hang Lung Properties; Professor Nancy Ip, President of HKUST; Professor Richard Schoen, Chair of the HLMA Scientific Committee; Professor Ngaiming Mok, Chair of the HLMA Steering Committee; and members of the Scientific Committee, Steering Committee, Executive Committee, and Screening Panel.
During the ceremony, a lively Panel Discussion was held on the theme of “Ubiquity of Mathematics: the Language of Discovery.” The discussion featured Professor Richard Schoen, 2017 Wolf Prize Laureate in Mathematics and Chair of the 2025 HLMA Scientific Committee, and Professor Ngaiming Mok, 2022 Future Science Prize Laureate, Chair of the HLMA Steering Committee and member of the Scientific Committee. Moderated by Ms. Jennifer Zhu Scott, Co-founder and Chief Executive Officer of Power Dynamics, the distinguished speakers shared their insights on the evolving landscape of mathematics education and the essential skills required for the next generation to thrive in a technology-driven era.
The 2025 Hang Lung Mathematics Awards attracted the participation of close to 100 teams from over 50 secondary schools in Hong Kong. Under the guidance of a supervising teacher, each team decided on a mathematics topic, designed and conducted research, and compiled their findings into a research report. This impactful initiative is pivotal in the cultivation of future mathematical and scientific minds.
Appendix
Founded in 2004, the Hang Lung Mathematics Awards is a biennial competition that inspires secondary school students to formulate their own research journey and realize their creative potential in mathematics. Throughout its illustrious history, 2,800 students from over 200 schools have participated, submitting more than 500 research reports. Hang Lung donates HK$2.5 million for each competition—HK$1 million is allocated as prize money with the remainder supporting HKUST in providing vital initiatives including academic consultation, assessment, administration, and educational outreach activities. HKUST also offers scholarships for teachers nominated by the winning schools to further their studies through the Master of Science Program in Mathematics for Educators.
Over the past two decades, the HLMA has made a profound impact on cultivating young mathematical talent, with many past winners having gone on to graduate from top universities worldwide and now contributing significantly to society through work in academia and professional fields. HLMA plays an important role in recognizing and fostering a lasting love of mathematical inquiry that extends far beyond secondary school.
This year, the Hang Lung Mathematics Awards drew participation from nearly 100 teams across over 50 secondary schools in Hong Kong. A total of 15 teams were shortlisted for the Oral Defense stage, where a Scientific Committee comprising internationally renowned scholars and educators evaluated the research reports through a rigorous, multi-step review process. The teams were invited to present and defend their findings before the Scientific Committee in a formal setting, an experience that closely resembles the oral defense process required for a postgraduate degree.
For a detailed list of winners of the 2025 Hang Lung Mathematics Awards, please refer to the attachment.
Attachment
List of Winners of the 2025 Hang Lung Mathematics Awards
Award
Research Title
Team Member(s)
Teacher
School Name
Gold
Markov Chains Associated with Ultraspherical Polynomials: an Analysis of Weak Convergence and First Passage Time Functionals
Siu Man Li
Mr. On Ping Chung
Hong Kong Chinese Women’s Club College
Silver
Incentric Subdivisions of Triangles and Iterated Function Systems
Augus Kui Lam Huang
Inna Belle Lee Chun Lam Lo Lok Hei Qiao Cheuk Lok Wong
Mr. Pak Leong Cheung
St. Paul’s Co-educational College
Bronze
On the Generalisations of the No-Three-in-Line Problem
Edison Sze Ho Fu Yun Tung Ko Hoi Chun Puk Wai Kwan Yeung
Mr. Hang Chun Chan
Queen’s College
Honorable Mentions (listed by school name in alphabetical order)
Research Title
Team Member(s)
Teacher
School Name
On the Number of Multiplicative Type En Friezes
Lok Him Chan David Kai Hei Gu Sui Ping Tang Ho Wong
Mr. Yuk Lun Fong
HKUGA College
What Can You Split and Draw?
Triton Cheuk Lok Kho Eron Ching Long Kwok Man Hei Tung
Mr. Yuk Lun Fong
HKUGA College
The Mathematics of Riffle Shuffling from Single to Multi-Deck Card Games
Daniel Haifeng Wang Justin Haisong Wang
Ms. Alexandra Streeter
King George V School
On the Images of Rational Numbers under a Certain Type of Fractal Interpolation Function
Tsz Hei Chiu Alex Sheung Fai Lam Hin Chun Lee Jamie Chun Hin Ng Ka Lam Tang
Dr. Wai Shan Cheung
St. Joseph’s College
Producing Annoying Sounds with Chalk by Varying Angle of Contact
Joshua Cheung Haoyang Dong Jizheng Li Ming Ze Li Maximilian Ng
Mr. David Bian
Victoria Shanghai Academy
Hashtag: #HangLungProperties
The issuer is solely responsible for the content of this announcement.
About Hang Lung Properties
Hang Lung Properties Limited (SEHK stock code: 00101) creates compelling spaces that enrich lives. Headquartered in Hong Kong, Hang Lung Properties develops and manages a diversified portfolio of world-class properties in Hong Kong and the nine Mainland cities of Shanghai, Shenyang, Jinan, Wuxi, Tianjin, Dalian, Kunming, Wuhan and Hangzhou. With its luxury positioning under the “66” brand, the company’s Mainland portfolio has established its leading position as the “Pulse of the City”. Hang Lung Properties is also recognized for leading the way in enhancing sustainability initiatives in the real estate industry, all the while pursuing sustainable growth by connecting customers and communities.
About The Hong Kong University of Science and Technology
The Hong Kong University of Science and Technology (HKUST) (https://hkust.edu.hk/) is a world-class university known for its innovative education, research excellence, and impactful knowledge transfer. With a holistic and interdisciplinary pedagogy approach, HKUST was ranked 6th in the QS Asia University Rankings 2026, 3rd in the Times Higher Education’s Young University Rankings 2024, and 19th globally and 1st in Hong Kong in the Times Higher Education’s Impact Rankings 2025. Thirteen HKUST subjects were ranked among the world’s top 50 in the QS World University Rankings by Subject 2025, with “Data Science and Artificial Intelligence” coming in 17th worldwide and first in Hong Kong. Our graduates are highly competitive, consistently ranking among the world’s top 30 most sought-after employees. In terms of research and entrepreneurship, over 80% of our work was rated “internationally excellent” or “world leading” in the Research Assessment Exercise 2020 of the Hong Kong’s University Grants Committee. As of July 2025, HKUST members have founded over 1,900 active start-ups, including 10 Unicorns and 17 exits (IPO or M&A).
TOKYO, Dec. 18, 2025 /PRNewswire/ — PRISM BioLab, Co. Ltd. (“PRISM”) and Talus Bioscience, Inc. (“Talus Bio”) announced today that they entered into a collaboration to discover novel Inhibitors of transcription factor (TF) and protein-protein interaction (PPI) targets. By combining Talus Bio’s assay technologies for screening for TF and PPI inhibitors in native cellular environment with PRISM’s chemistry designed to target protein-protein interactions, companies are in a unique position to discover and develop drugs against these challenging targets.
Under the agreement, the companies will deploy PRISM’s proprietary small-molecule libraries in Talus Bio’s AI-guided regulome profiling screens to identify and optimize novel compounds against high-value TF and PPI targets. The collaboration aims to generate first-in-class chemical matter with direct functional effects on TF and PPI activity in live human cells. Talus Bio and PRISM will share the costs of discovery research and development and any profits generated from out-licensing and commercialization of discovered drug products.
“We are delighted to partner with Talus Bio on this exciting project”, commented Dai Takehara, PRISM’s President and CEO. “We at PRISM have developed chemistries for PPI targets, but because of the complex nature of these targets, it is often challenging to properly model protein-protein interactions in a biochemical assay. Even when we are successful, we can interrogate only one target at a time, whereas Talus Bio technologies can interrogate hundreds to thousands of these targets in parallel and in their native environment. We believe that the combination of PRISM’s chemistry platform and Talus Bio’s regulome analysis platform has a potential to discover a plethora of inhibitors against previously “undruggable” TF and PPI targets and open a path for the development of novel therapeutics.
“This collaboration gives us an unprecedented opportunity to pursue targets that have resisted conventional drug discovery,” said Alex Federation, PhD, CEO and Co-Founder of Talus Bio. “Integrating PRISM’s chemistry with Talus Bio’s regulome profiling and AI models allows us to see, in real time, how compounds reshape transcriptional networks in human cells. It’s a step-change in our ability to drug the undruggable.”
This collaboration represents a pivotal step for both companies in establishing a systematic, scalable strategy to address TF and PPI targets. Together, PRISM and Talus Bio are creating a unified platform capable of revealing and modulating regulatory mechanisms that have remained undruggable for decades. By combining PRISM’s PepMetics® technology with Talus Bio’s regulome profiling capabilities, the collaboration opens the door to therapies addressing diseases caused by previously undruggable targets.
About Talus Biosciences
Talus Bio is making the regulome accessible to drug discovery. Founded in 2020, the Seattle-based company’s platform generates global profiles of the regulome, including transcription factors and other DNA regulators directly in native human cells. These quantitative maps of regulome activity unlock new avenues to target historically “undruggable” proteins that function within the regulome.
This data is leveraged to build a lab-in-the-loop AI system to discover and optimize small molecules with direct effects on regulome activity. With the world’s most comprehensive regulome activity dataset and a multidisciplinary team spanning high-throughput proteomics, machine learning, and AI-native drug discovery, Talus Bio is unlocking a new generation of precision therapeutics.
PRISM BioLab is a discovery and development biotechnology company utilizing proprietary PepMetics® technology to discover orally available small molecule inhibitors of protein-protein interaction (PPI) targets and transform lives of patients suffering from cancer, autoimmune, fibrosis and other diseases. PepMetics® are a unique class of small molecules that mimic three-dimensional structures of alpha-helix and beta-turn, the peptide structures commonly found in intracellular PPI interphases and receptor-ligand interactions. By combining proprietary chemistry, know-how around PPI targets and structure-based design, PepMetics® technology can deliver inhibitors of challenging PPI targets. The technology holds promise to expand the field of drug discovery by turning previously undruggable PPIs into targets readily druggable with small molecules and by generating oral small molecule alternatives for injectable biologics.
PRISM BioLab is collaborating on new PPI targets with global and Japanese pharmaceutical companies. PepMetics® targeting CBP/beta-catenin PPIs licensed to Eisai Co., Ltd. and Ohara Pharmaceuticals Co., Ltd. are in clinical development for cancer and liver disease, respectively.
www.hanglung.com
