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Inspira Enterprise Recognized as a Leader in the Cybersecurity Services for Mid-Market Enterprises PEAK Matrix® Assessment 2025 by Everest Group

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MUMBAI, India, Nov. 7, 2025 /PRNewswire/ — Inspira Enterprise, a global leader in cybersecurity services, today announced that it has been recognized as a Leader in Everest Group’s Cybersecurity Services for Mid-Market Enterprises PEAK Matrix® Assessment 2025. This recognition highlights Inspira’s AI-driven cybersecurity services, tailored specifically for mid-market enterprises globally.

Commenting on the achievement, Chetan Jain, Managing Director, Inspira Enterprise, remarked, “We are truly honored to be recognized as one of the leaders by Everest Group. This validates our team’s dedication and excellence in delivering advanced AI-driven cybersecurity services to safeguard the digital assets of our customers. We will continue to further invest and focus on building resilient, AI-driven, and automation-enabled security for the global mid-market segment.”

Everest Group has recognized Inspira Enterprise for its strong domain knowledge, proactive account management, and comprehensive MDR services. Mid-market enterprises seeking secure AI adoption can leverage Inspira’s AI governance and assured services. Its iSMART² platform further enhances cybersecurity management with CXO dashboards, TRPM workflows, and cyber-risk mapping.

“Mid-market firms hold a significant amount of sensitive business and customer data and are attractive targets for cybercriminals. They house complex environments, but the lack of resources of large enterprises makes them vulnerable to breaches, leading to losses on several fronts. Cybersecurity service providers for this segment have to deliver advanced security capabilities with agility while remaining cost-effective. Inspira Enterprises has exhibited these traits and earned a Leader position in the Everest Group Cybersecurity Services for Mid-Market Enterprises PEAK Matrix® Assessment 2025,” says Kumar Avijit, Vice President, Everest Group.

For more information, visit: https://inspiraenterprise.com/everest-group-cybersecurity-services-for-mid-market-enterprises-peak-matrix-assessment-2025/

About Inspira Enterprise

Inspira Enterprise is a global Cybersecurity, Data Analytics, and Artificial Intelligence services provider with a presence in North America, ASEAN, the Middle East, Africa, and India. It delivers adaptive, intelligent, and customer-centric solutions to diverse industries.

With 1600+ professionals, Inspira successfully delivers complex transformation projects for 550+ clients. Its AI and cybersecurity capabilities empower businesses to build resilient, future-ready digital ecosystems. Learn more: www.inspiraenterprise.com.

Contact:
Deepak I J,
deepak.ij@inspiraenterprise.com 

About Everest Group

Everest Group is a leading global research firm helping business leaders make confident decisions. Everest Group’s PEAK Matrix® assessments provide the analysis and insights enterprises need to make critical selection decisions about global services providers, locations, and products and solutions within various market segments. Find further details and in-depth content at www.everestgrp.com.

Disclaimer 

Licensed extracts taken from Everest Group’s PEAK Matrix® Reports, may be used by licensed third parties for use in their own marketing and promotional activities and collateral. Selected extracts from Everest Group’s PEAK Matrix® reports do not necessarily provide the full context of our research and analysis. All research and analysis conducted by Everest Group’s analysts and included in Everest Group’s PEAK Matrix® reports is independent and no organization has paid a fee to be featured or to influence their positioning.  To access the complete research and to learn more about our methodology, please visit Everest Group PEAK Matrix® Reports. 

 

Luxshare Precision Reports Strong Revenue and Profit Growth in Q3 2025 Results

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HONG KONG SAR – Media OutReach Newswire – 7 November 2025 – Luxshare Precision (002475.SZ) announced its Q3 2025 financial results on October 30. In the third quarter, the company achieved approximately RMB96.411 billion in revenue, reflecting a year-on-year growth of 31.03%. The net profit attributable to shareholders of the listed company reached RMB4.874 billion, marking a year-on-year increase of 32.49%. For the first three quarters of 2025, the company achieved approximately RMB220.915 billion in revenue, representing a year-on-year growth of 24.69%, and the net profit attributable to shareholders of the listed company reached RMB11.518 billion, up 26.92% year-on-year. Basic earnings per share stood at RMB1.59, increasing 26.19% compared to the same period last year.

According to the report, in the first three quarters of 2025, despite the complex and evolving global political and economic landscape and the ongoing restructuring of global supply chains, the company seized strategic opportunities and remained committed to executing its “Three Five-Year” strategic plan, achieving steady and high-quality growth. The company continued to strengthen its three core business segments—consumer electronics, communications and data centers, and automotive—driving coordinated development across these segments through a development strategy driven by “organic growth and external expansion” twin engines.

Sustained Growth Momentum in Consumer Electronics
Luxshare Precision continued to deliver solid performance in the consumer electronics segment, reflecting its strong technological capabilities. In September 2025, Apple unveiled the iPhone 17 series. According to Counterpoint Research, sales in the first 10 days after launch were 14% higher than those of the iPhone 16 series during the same period, with sales of the standard model in China nearly doubling. Luxshare Precision undertook full-series production of the iPhone 17, participating extensively from component manufacturing to final assembly, covering key modules such as wireless chargers, acoustic components, and linear motors—demonstrating its comprehensive vertical integration advantage. Guotai Haitong Securities noted that the strong market response to the iPhone 17, together with the anticipated launch of the foldable iPhone and potential AI functionality upgrades in iOS 26.4 in 2026, could accelerate replacement demand among existing users, further driving Apple’s overall shipment growth and enhancing Luxshare Precision’s profit flexibility.

At the same time, Luxshare Precision completed the acquisition of equity interests and assets from several subsidiaries under Wingtech Technology on July 2, expanding its ODM’s manufacturing capacity and customer base while creating synergies with its existing clients. According to Guosen Securities, non-recurring gains made a notable contribution to Luxshare Precision’s third-quarter results, with income of RMB 479 million arising from “the acquisition cost of subsidiaries being lower than the fair value of the identifiable net assets acquired” (including Leoni and Wingtech’s ODM/OEM assets), reflecting accounting gains generated through external expansion.

Amid the wave of AI-driven intelligent transformation, demand for smart devices such as AI smartphones, AI laptops, and AR/VR products has surged, driving the need for high-precision, miniaturized, and multi-functional integrated components. Leveraging its accumulated expertise in acoustics, optics, electronics, thermal management, radio frequency, and structural parts, together with its vertically integrated manufacturing capabilities, Luxshare Precision has become one of the few suppliers capable of providing comprehensive AI terminal solutions, injecting new momentum into the company’s sustained business growth.

Steady Momentum in AI and Automotive Businesses
The communications and data center segment benefited from the rapid global growth of generative AI applications, as AI servers and data center infrastructure construction continued to accelerate, driving increased demand for high-speed optoelectronic interconnects, thermal management, and power solutions. Luxshare Precision possesses vertically integrated capabilities in high-speed interconnect and optoelectronic technologies, with related products already adopted by multiple global cloud service providers and equipment manufacturers, supporting steady expansion of the segment’s business scale.

Leveraging its strengths in connector technology, Luxshare Precision has achieved full-chain integration for 224G electrical connections. At the China International Optoelectronic Exposition (CIOE) held in Shenzhen in September, the company showcased AI server application solutions including CPC (Co-Packaged Copper Interconnection), CPO (Co-Packaged Optics), and HVDC (High-Density Power), demonstrating further enhancement of its R&D and supply capabilities in AI cluster components. Meanwhile, the company has been actively expanding cooperation with global technology leaders such as NVIDIA and Meta, which is expected to become a new growth driver for its business performance.

In the automotive segment, as the penetration of smart cockpit and autonomous driving technologies continues to rise, the industry’s transformation toward electrification, connectivity, intelligence, and shared mobility has further deepened. Luxshare Precision is progressively expanding its product applications from traditional wiring harnesses and automotive connectors to smart cockpit systems, driver-assistance solutions, and powertrain components. Leveraging Leoni Group’s global production capacity and distribution network, the company is strengthening collaboration with international OEMs, driving steady growth in automotive component shipments and an increasing contribution from this segment to overall revenue.

Luxshare Precision is actively advancing its proposed listing in Hong Kong to further broaden its access to overseas capital markets. On August 18, 2025, Luxshare Precision officially submitted a listing application to the Hong Kong Stock Exchange. This application marks a substantial step forward in Luxshare Precision’s capital market operations and internationalization strategy, providing greater financial flexibility to support the sustained development of its core business segments in AI terminals, communications, and automotive.

Luxshare Precision expects its net profit attributable to shareholders of the listed company for the entire year of 2025 will reach between RMB 16.52 billion and RMB 17.19 billion, representing a year-on-year increase of 23.6% to 28.6%, with earnings per share estimated at RMB 2.28 to 2.37. The company continues to deepen its globalization strategy, leveraging its overseas bases as strategic hubs to flexibly respond to regional demand and deliver resilient, cost-efficient global manufacturing solutions. Having been listed among the Fortune Global 500 for three consecutive years, Luxshare Precision will continue to drive steady business growth through a development strategy driven by “organic growth and external expansion” twin engines. Looking ahead, as the company advances its Hong Kong listing process, it is expected to further broaden its global capital market presence, strengthen its international competitiveness, and create greater value for investors and partners.

Hashtag: #LuxsharePrecision

The issuer is solely responsible for the content of this announcement.

Fosun International Honored with Gold Award and Best Sustainability Team at The Asset Corporate Sustainability Leadership Awards 2025

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HONG KONG, Nov. 7, 2025 /PRNewswire/ — On the evening of 6 November 2025, The Asset, a renowned Asian financial magazine, hosted “The Asset Corporate Sustainability Leadership Awards 2025” ceremony in Singapore. Fosun International Limited (“Fosun International” or the “Company”) (HKEX stock code: 00656) was awarded “The Asset Corporate Sustainability Leadership Awards 2025 – Gold Award” and the “Best Sustainability Team”.

Coinciding with The Asset’s 25th anniversary, the highly regarded “The Asset ESG Corporate Awards” was renamed “The Asset Corporate Sustainability Leadership Awards” this year, underscoring the winning companies’ more comprehensive and holistic commitment to advancing sustainable development. After years of refinement in its selection process, the awards have become one of the most authoritative and influential ESG awards in the Asia-Pacific region. Fosun International received “The Asset Corporate Sustainability Leadership Awards 2025 – Gold Award” in recognition of its outstanding performance in areas including financial performance, corporate governance, social responsibility, environmental protection, investor relations, information disclosure and corporate communication.

Fosun’s remarkable ESG performance has been widely recognized by the international market

Looking back on the past, Fosun has always paid attention to the reform and development of the global policies in the field of sustainable development. It has established a robust ESG governance structure and management system, embedding sustainability principles into its operations over the years. It has actively responded to national and global strategies in relation to sustainable development, ensured information security, promoted technology innovation, implemented “dual carbon” goals, protected the rights and interests of employees to promote sustainable management and value creation.

Thanks to its sustained commitment to ESG over the years, Fosun International has consistently achieved excellent results in ESG ratings globally. As of now, Fosun International has maintained an MSCI ESG rating of AA. In 2025, it has been once again included in the S&P Global Sustainability Yearbook 2025 and has been selected as the top 1% in S&P Global Sustainability Yearbook 2025 (China Edition). It has received an HSI sustainability rating of AA- and has been consecutively included in the Hang Seng Corporate Sustainability Benchmark Index. Fosun has also retained a leading FTSE Russell ESG score and has continued to be selected as a constituent stock of the FTSE4Good Index Series.

Driven by innovation, committed to social contribution

Fosun adheres to an innovation-driven strategy, continuously delivering innovative achievements across its businesses to better serve society. To date, Fosun’s innovative biopharmaceutical products have reached nearly 60 countries and regions, benefiting more than 850,000 patients worldwide. Among them, HANQUYOU, a core product in breast cancer treatment, is a China-developed monoclonal antibody biosimilar approved in China, the European Union, and the United States. It has been approved for marketing in more than 50 countries and regions worldwide. In addition, HANSIZHUANG, an innovative anti-PD-1 monoclonal antibody independently developed by Fosun, is the world’s first anti-PD-1 monoclonal antibody approved for the first-line treatment of small cell lung cancer (SCLC). To date, it has been approved for marketing in nearly 40 countries and regions, including China, the European Union, the United Kingdom, Singapore, and India, benefiting more than 110,000 patients worldwide.

Since the beginning of this year, Fosun has achieved multiple breakthroughs in the field of innovative drugs. HLX43, a PD-L1-targeting antibody-drug conjugate (ADC) is undergoing clinical studies for solid tumors such as non-small cell lung cancer and thymic carcinoma in countries including China, the United States, Japan, and Australia. Currently, no PD-L1 ADC has been approved globally, positioning HLX43 as a potential highly effective and safe broad-spectrum anticancer drug. Additionally, in the field of innovative small molecule drugs, FUMAINING, a targeted drug independently developed by Fosun, has been approved for two rare disease indications, filling the treatment gap in the field of rare tumors.

Fosun Pharma has consistently contributed the “China Solution” to the fight against malaria in Africa. As at the end of June 2025, its independently developed artesunate for injection had been used to treat more than 84 million patients with severe malaria worldwide. Additionally, Fosun Pharma had cumulatively supplied over 420 million doses of artesunate for injection globally.

In order to better promote the fulfillment and implementation of corporate social responsibility, Fosun Foundation was established in 2012. It has been making unremitting efforts in the fields of global emergency relief, rural revitalization, health, education, culture and art, youth development, etc. to create social value. Of which, since its launch at the end of 2017, Fosun Foundation’s Rural Doctors Program has covered 78 counties in 16 provinces, cities, and autonomous regions, supported 25,000 rural doctors, and benefited 3 million rural families.

Actively responding to climate change and promoting low-carbon transformation

Fosun has moved beyond passive adaptation to actively driving climate action through innovation. Under the leadership of its Board of Directors (the “Board”) and Carbon Neutrality Committee, the Group has integrated carbon neutrality into management performance appraisal, established a carbon emission management system, and provided greenhouse gas inventory training. Advancing its low-carbon transformation, Fosun is harnessing innovative technologies to create a more sustainable industrial chain and eco-friendly consumer products.

With climate change being one of the most severe long-term risks, Fosun recognizes the importance of global cooperation to tackle this challenge. Fosun remains committed to advancing China’s “dual carbon” goals by promoting carbon neutrality and energy conservation and emission reduction. In 2021, Fosun made a commitment to society – “strive to peak carbon emissions by 2028 and achieve carbon neutrality by 2050”. Fosun has formulated strategies for climate change mitigation and adaptation to align with the 1.5°C temperature control target set in the Paris Agreement.

Built a comprehensive mechanism for ESG management to effectively implement ESG strategies and actions

Fosun has been actively focusing on how to undertake more social responsibility. It is also committed to further optimizing corporate governance, focusing on the healthy development of sustainable businesses, extending from the Board of Directors to daily operations. Fosun has set up an ESG Board Committee under the Board to assist the Board in guiding and overseeing the Group’s ESG development and implementation. At the management and decision-making level, Fosun has established an ESG Executive Committee to provide decision support for the implementation of ESG strategies. At the implementation level, the Group has also set up an ESG Management Committee and an ESG Working Group to implement ESG strategies and related actions and ensure the establishment of appropriate and effective ESG risk management and internal control system.

Fosun prioritizes sustainability and fosters an ESG culture from the top down. Fosun’s ESG Management Committee and ESG Working Group regularly hold meetings and workshops including ESG global networking workshop, ESG culture week, ESG digital platform, encourage knowledge and experience sharing related to ESG among employees and subsidiaries, to help establish open communication channels within the Group and assist in promoting ESG development in subsidiaries. The Asset awarded Fosun International “Best Sustainability Team”, which reflects the market’s recognition of the Company’s ESG management and the Company’s active promotion of environmental protection, social responsibility, and corporate governance.

Looking ahead, as a global enterprise rooted in China, Fosun will continue to uphold its original aspiration of “Contribution to Society”. Through continuous innovation and responsible global operations, Fosun will actively shoulder more social responsibility, striving to build a more responsible, inclusive, and sustainable future.

MVGX Debuts at the China International Import Expo to Strengthen Singapore-China Green Trade Collaboration

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SINGAPORE, Nov. 7, 2025 /PRNewswire/ — MVGX, a Singapore-based global leader in Sustainable AI and Green Finance Technology, made its debut at the China International Import Expo (CIIE 2025) as part of the Singapore Sustainable Development Business Alliance.

Frank Zhang, President of MVGX (third from right), attends the China–Singapore Green Urban Collaboration Conference
Frank Zhang, President of MVGX (third from right), attends the China–Singapore Green Urban Collaboration Conference

Held from 5 to 10 November in Shanghai, this year’s CIIE brings together participants from 155 countries, regions, and international organisations. The event features 4,108 overseas enterprises exhibiting across a record-breaking 430,000 square metres, reflecting the event’s growing significance as a global platform for sustainable trade and innovation.

Under the theme “Singapore–China: Envisioning the Next Horizon”, the Singapore Pavilion features 57 companies, including 18 first-time exhibitors. Among them, MVGX showcases its three core business pillars: Green Asset Trading, Sustainable AI Technology Services, and Green Finance Solutions, as part of its mission to advance green trade and deepen cooperation between Singapore and China.

Promoting Green Trade, Sharing a Sustainable Future

Amid accelerating global green investment and the pursuit of “dual carbon” goals, MVGX believes that green value should move beyond policy vision to become market-driven action. Its participation in CIIE 2025 marks a significant step in strengthening collaboration between Singapore and China across areas such as green infrastructure, low-carbon projects, and zero-carbon industrial parks.

As part of Singapore’s national delegation, MVGX is engaging with buyers, institutional investors, and project developers from China and beyond. The company is demonstrating how its technologies can transform carbon credits and green assets into financeable and compliant products.

By leveraging this global trade platform, MVGX aims to serve as a bridge of innovation, driving tangible cooperation in green finance and low-carbon transformation between the two nations.

About MVGX

MVGX Tech is a global leader in Sustainable AI and Green Finance Technology, specialising in three key areas: Green Asset Trading, Sustainable AI Services and Green Finance Solutions. By integrating expertise in artificial intelligence, sustainability and RWA-compliant green finance, MVGX provides end-to-end, internationally compliant solutions, from carbon tracking, reporting and compliance management to the integration of green assets into sustainable finance. Its mission is to empower organisations to accelerate their sustainability goals through technology-enabled transparency, trust and impact.

 

Pixelworks’ Distributed Rendering Solution Empowers realme’s GT8 Series R1 Gaming Chip to Achieve a Performance Leap

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Distributed Rendering Solution Unlocks a New Visual Experience with Low Power Consumption and High Image Quality

SHANGHAI, Nov. 7, 2025 /PRNewswire/ — Pixelworks, Inc. (NASDAQ: PXLW), a leading provider of visual processing solutions, today announced that it offers an advanced distributed rendering solution for the R1 gaming chip equipped in the realme GT8 series smartphones. By integrating ultra-low latency MotionEngine® technology, efficient AI game Super Resolution technology, and always-on HDR technology, this solution brings an all-round upgrade to the R1 gaming chip and provides users with a brand-new visual experience.

With the adoption of neural network algorithm based AI distributed computing architecture, Pixelworks’ solution has been deeply optimized on the basis of traditional rendering architecture, supporting the R1 gaming chip’s ability to reduce GPU computing power burden and significantly improve the rendering capabilities of smartphones. For the gaming experience, the distributed rendering solution enables the R1 gaming chip to achieve super-resolution and super-frame up to 2K resolution and 144fps, making the picture smoother and clearer. Gaming players can enjoy PC-level image quality in over a hundred games with low power consumption.

In terms of video experience, the R1 gaming chip supports multiple functions such as dynamic frame interpolation, dynamic ultra-high definition and color enhancement. Pixelworks’ distributed rendering solution provides the underlying technical support, further improving the image brightness and contrast, and enhancing the sense of depth and layering. By leveraging the R1 chip, the full potential of the mobile phone is unleashed and the video frame rate is enhanced. Additionally, low frame rate video content can be presented stably with excellent visual quality, even on high refresh rate smartphones.

“As a milestone product for realme’s 300 million sales, the realme GT8 series has achieved a comprehensive leap in performance, imaging, and design,” said Chase Xu, Vice President of realme. “For a more visually appealing experience, we partnered with Pixelworks to integrate the distributed rendering solution into the R1 chip, further breaking through the ceiling of visual effects and bringing users an immersive visual experience.”

Commenting on this cooperation, Jun Fang, Vice President of Pixelworks and General Manager of Mobile Business Unit, stated, “It’s a great pleasure to join hands with realme again and continue our cooperation on the GT8 series to achieve a leap forward in both performance and imaging, which reflects realme’s commitment to continuously improving the user experience. Pixelworks is honored to be a part of this effort, offering professional visual processing solutions that expand the realm of gaming and video quality, while also bringing consumers a refreshing visual experience.”

About realme:

realme is a global consumer technology company disrupting the smartphone market by making cutting-edge technologies more accessible. It provides a range of smartphones and lifestyle technology devices with premium specs, quality, and trend-setting designs to young consumers.

Established by Sky Li in 2018 and driven by its “Dare to Leap” spirit, realme has become one of the top 5 smartphone players in 30 markets globally in just three years, and realme has entered multiple markets worldwide, including China and Southeast Asia, South Asia, Europe, the Middle East, Latin America, and Africa, and has a global user base of over 160 million.

For more information, please visit www.realme.com.

About Pixelworks

Pixelworks provides industry-leading content creation, video delivery and display processing solutions and technology that enable highly authentic viewing experiences with superior visual quality, across all screens – from cinema to smartphone and beyond. The Company has more than 20 years of history delivering image processing innovation to leading providers of consumer electronics, professional displays and video streaming services. For more information, please visit the company’s website at www.pixelworks.com.

Note: Pixelworks, MotionEngine and the Pixelworks logo are registered trademarks of Pixelworks, Inc. All other trademarks are the property of their respective owners.


 

Volpara Now Operates Under Lunit Brand, Advancing a Unified Vision for AI Cancer Intelligence

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The rebranding marks the first phase of Lunit’s unified global identity, connecting breast health, AI detection, and precision oncology under one name.

SEOUL, South Korea, Nov. 7, 2025 /PRNewswire/ — Lunit (KRX: 328130), a leading provider of AI for cancer diagnostics and therapeutics, today announced that Volpara Health Technologies will now operate under the Lunit brand, introducing a unified global identity that merges their complementary strengths in breast health and AI innovation.

This milestone builds on Lunit’s 2024 acquisition of Volpara, an important step that aligned both companies under one vision: to conquer cancer through AI.

The integration builds a comprehensive ecosystem spanning risk prediction, early detection, imaging quality, and data-driven precision medicine, delivering greater value for clinicians, researchers, and patients worldwide. This positions Lunit among the few AI healthcare companies with a comprehensive cancer intelligence portfolio—from breast health and screening to precision oncology—serving over 10,000 healthcare providers across more than 65 countries.

“By bringing Volpara under the Lunit brand, we’re uniting our technologies, teams, and mission to deliver a connected ecosystem that transforms how cancer is detected and treated worldwide,” said Brandon Suh, CEO of Lunit. “This marks the start of a new era of collaboration and impact across every stage of cancer care.”

To accelerate and enhance regional growth, Lunit is evolving its global operations under a unified structure. Lunit International (formerly Volpara Health Technologies) encompassing all former Volpara operations across the U.S., Oceania, Europe, and Asia, will lead Lunit’s business development and customer engagement efforts in these markets.

In parallel, Lunit is transitioning part of its global sales organization into these regional hubs, allowing the Seoul headquarters to focus on AI research, innovation, and new product development—further sharpening its global focus and specialization.

As part of this milestone, Lunit has launched a newly designed website (www.lunit.io/en), reflecting its new digital identity and serving as a single digital gateway to its AI solutions, research, and corporate resources.

“Our mission remains the same,” added Suh. “We aim to make AI the new standard for the entire cancer journey. We want every patient, regardless of geography or resources, to benefit from the same level of precision and insight, ensuring equitable access to life-saving diagnostics worldwide.”

About Lunit

Founded in 2013, Lunit (KRX: 328130) is a global leader on a mission to conquer cancer through AI. Our clinically validated solutions span medical imaging, breast health, and biomarker analysis—empowering earlier detection, smarter treatment decisions, and more precise outcomes across the cancer care continuum.

Following the integration of Volpara, Lunit now offers a comprehensive suite spanning risk prediction and early detection to precision oncology. Our FDA-cleared Lunit INSIGHT suite and breast health solutions support cancer screening in thousands of medical institutions worldwide, while Lunit SCOPE platform is used in research partnership with global pharma leaders for biomarker development and companion diagnostics.

Trusted by over 10,000 sites in more than 65 countries, Lunit combines deep medical expertise with continuously evolving datasets to deliver measurable impact—for patients, clinicians, and researchers alike. Headquartered in Seoul with global offices, Lunit is driving the worldwide fight against cancer. Learn more at lunit.io/en.

ACAAI 2025 | CS2015 (OX40L/TSLP Bispecific Antibody) Makes International Debut

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SUZHOU, China, Nov. 7, 2025 /PRNewswire/ — CStone Pharmaceuticals (“CStone,” HKEX: 2616), an innovation-driven biopharmaceutical company focused on the research and development of therapies for oncology, autoimmune/inflammation, and other key disease areas, today announced that the Company will present one of its autoimmune and inflammation pipeline assets, CS2015 (OX40L/TSLP bispecific antibody), in the format of an ePoster plus an on-site oral presentation at the 2025 Annual Scientific Meeting of the American College of Allergy, Asthma & Immunology (ACAAI). ACAAI is one of the most influential academic conferences in the fields of allergies, asthma, and immunology, attracting experts and scholars around the world to discuss the latest scientific advancements. This marks the first presentation of CS2015 at an international academic conference. The full content of the abstract and eposter is now officially available on the ACAAI website.

Key highlights of the presentation:

CS2015 features an asymmetric molecular design that simultaneously targets OX40L and TSLP, two clinically validated critical regulators of type 2 inflammation. The molecule incorporates an engineered Fc region with reduced binding affinity for FcγR, which extends its in vivo half-life and optimizes its pharmacokinetic (PK) profile to support long-term dosing intervals. CS2015 also exhibits excellent molecular stability, facilitating the development of high-concentration subcutaneous formulations. Its strong developability profile further supports high-yield and scalable manufacturing.

1.      Dual Blockade:

CS2015 lead molecule demonstrated potent inhibition of OX40L/OX40 and TSLP/TSLPR downstream signaling:

  • CS2015 potently interrupted the engagement of hOX40L on hOX40 reporter cells and hTSLP on hTSLPR/IL-7Rα reporter cells, respectively;
  • The blocking activities of CS2015 were comparable to those of benchmark (parental) antibodies, with single or sub nanomolar IC50s.

2.      Robust Inhibition of Inflammatory Responses:

CS2015 lead molecule inhibited the release of inflammatory cytokines from primary CD4+ T cells stimulated by TSLP/OX40L and suppressed TSLP-induced release of TARC (CCL17) in human monocytes and peripheral blood mononuclear cells (PBMC).

3.      Early Signs of Efficacy:

CS2015 demonstrated potent disease control activities in Atopic Dermatitis (AD) model with OX40 and TSLP humanized mice. In MC903-induced AD models, CS2015 lead molecule:

  • Rapidly reduced skin lesion severity including ear and epidermal thickening;
  • Decreased immune cells, especially mast cells infiltration;
  • Reduced itch events.

4.      Durability Advantage:

CS2015 demonstrated superb PK profiles in Non-Human Primate (NHP), supporting long-term dosing intervals:

  • CS2015 lead molecule K19LS exhibited a mean half-life of 21 days (504.6 hours, Subcutaneous [SC]) and 25.7 days (617.6 hours, Intravenous [IV]);
  • K19LS had a clearance rate of 2.4 (SC) and 2.7 (IV) ml/day/kg, and was well-absorbed, with outstanding bioavailability.

5.      Outstanding drug-like properties:

Beyond the data shown in the poster, CS2015 further demonstrated:

  • Outstanding accelerated stability under high-temperature stress (40°C);
  • Low viscosity (scored at only 3.7 for a 100 mg/ml solution), promising for subcutaneous injection at high-concentration;
  • Potent efficacy in the intranasal OVA/TSLP-induced asthma model by decreasing the secretion of IL-4, CCL17, IgE, etc., and alleviating pulmonary pathological changes.

CStone will further advance the development of CS2015 to treat Th2 cell-mediated inflammation diseases, including AD, asthma, hidradenitis suppurativa (HS), chronic obstructive pulmonary disease (COPD), Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), etc.

The presentation schedule is as follows:
Title: CS2015 a TSLP/OX40L Bispecific Antibody as a Potential Novel Therapeutic Agent for Type 2 Inflammation Diseases
Presentation Type: ePoster display & 15-min on-site oral presentation (ePoster ID: R377)
Abstract ID: 8079
Date & Time: Friday, November 7, 3:05 PM ET
Location: ePoster Area of the West Exhibit Hall, Monitor 22
*The abstract and ePoster have been officially available on ACAAI website: https://epostersonline.com/acaai2025/.

About CStone

CStone (HKEX: 2616), established in late 2015, is an innovation-driven biopharmaceutical company focused on the research and development of therapies for oncology, autoimmune/inflammation, and other key disease areas. Dedicated to addressing patients’ unmet medical needs in China and globally, the Company has made significant strides since its inception. To date, the Company has successfully launched 4 innovative drugs and secured approvals for 16 new drug applications covering 9 indications. The company’s pipeline is balanced by 16 promising candidates, featuring potentially first-in-class or best-in-class antibody-drug conjugates (ADCs), multispecific antibodies, immunotherapies and precision medicines. CStone also prides itself on a management team with comprehensive experiences and capabilities that span the entire drug development spectrum, from preclinical and translational research to clinical development, drug manufacturing, business development, and commercialization. For more information about CStone, please visit: www.cstonepharma.com. 

Forward-looking statements

The forward-looking statements made in this article only relate to events or information as of the date when the statements are made in this article. Except as required by law, we undertake no obligation to update or publicly revise any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. All statements in this article are made on the date of publication of this article and may change due to future developments.

Disclaimer: only for communication and scientific use by medical and health professionals, it is not intended for promotional purposes.

Quantinuum Selected by DARPA to Advance to Stage B of Quantum Benchmarking Initiative

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With the industry’s most advanced quantum systems and proven ability to scale, Quantinuum is on track to deliver utility-scale quantum computing by early 2030s

BROOMFIELD, Colo., Nov. 7, 2025 /PRNewswire/ — Quantinuum, the world leader in quantum computing, has been selected by the Defense Advanced Research Projects Agency (DARPA) as a contractor to advance to Stage B of DARPA’s Quantum Benchmarking Initiative (QBI).

DARPA is using QBI to evaluate the technical likelihood that a utility scale quantum computer will be available no later than 2033. A multi-stage program, Stage B follows a six-month Stage A effort in which Quantinuum developed and delivered a detailed concept design for a utility scale system called “Lumos.”

Last year, Quantinuum released its public roadmap through the end of the decade with Apollo—a universal, fully fault-tolerant quantum computer—scheduled for launch in 2029. Lumos is a new addition to the roadmap as Quantinuum outlines plans to develop increasingly larger systems into the 2030s.

“This selection recognizes the strength and maturity of our roadmap and the work our teams have already delivered,” said Dr. Rajeeb Hazra, President and CEO of Quantinuum. “Lumos extends our roadmap into the next decade and gives DARPA a concrete, de-risked path for achieving utility-scale quantum computing by 2033. We look forward to partnering with DARPA and our ecosystem partners to advance this important national objective.”

Stage B will be a year-long, performance-based evaluation by DARPA’s Test and Evaluation team in which Quantinuum will develop a detailed R&D roadmap for Lumos to validate technical assumptions, verification methods, and scaling plans to meet the 2033 objective.

Yesterday, Quantinuum deployed its latest generation system, “Helios,” on schedule with its roadmap. With the highest fidelity physical qubits and logical qubits of any commercial system, and a next-generation software stack featuring a modern, high-level programming language, Helios is designed to accelerate quantum computing adoption. The system has already been used to simulate high-temperature superconductivity and magnetism at unprecedented scales—two applications with relevance to critical, industrial utility.  

About Quantinuum

Quantinuum is the world leader in quantum computing. The company’s quantum systems deliver the highest performance across all industry benchmarks. Quantinuum’s over 630 employees, including 370+ scientists and engineers, across the US, UK, Germany, and Japan, are driving the quantum computing revolution. 

For more information, please visit www.quantinuum.com

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