ROCKAWAY, N.J., Oct. 23, 2025 /PRNewswire/ — TOPDON US (https://www.topdon.us/) has innovated two of the company’s most popular products, the RLink J2534 (https://www.topdon.us/products/rlink-j2534) and TopScan (https://www.topdon.us/products/topscan) with more robust technology and features for greater use and flexibility. Developed using customer feedback, the RLink J2534 now offers the diagnostic capabilities of the TopScan in addition to its robust programming and coding functionality. RLink J2534 and RLink X7 owners now get one year of the TopScan app access free (a $99 value). The newly innovated RLink J2534 is now available through TOPDON’s national distribution network.

“We go to great lengths to listen to our customer feedback,” said Chad Schnitz, Vice President of TOPDON US. “Our customers use our products every day, so their feedback is critical in helping us identify opportunities for improvement. Every enhancement we deliver, like the updates made to the RLink J2534, are a direct reflection of the insights our customers share with us.”

Now available with TopScan software that performs all 10 modes of OBD2 testing, the RLink J2534 is one of the most cost-effective programming and diagnostic tools on the market. Through the Topscan software integration, it offers instant access to crucial information for thousands of vehicles while also fully supporting all J2534 protocols, ensuring compatibility with OEM reprogramming and diagnostic functions.

“The enhancements we’ve made to the RLink J2534 ensure it will continue to deliver real value and adapt to our customers evolving needs,” said Schnitz. “Over the last eight years in the North American market, TOPDON has constantly sought a higher standard of performance, at a price point that doesn’t break the bank. The improvements we’ve made to the RLink J2534 are evidence of the trust we have in our customers and how we are leading in a rapidly changing marketplace.”

About TOPDON US
Founded in 2017 and based in Rockaway, New Jersey, TOPDON US is a provider of entry-level, mid-level, and advanced tools and solutions for professional technicians, as well as DIY enthusiasts. Globally, TOPDON has over 250 industry-leading engineers and owns over 500 patents and software copyrights. The company’s cutting-edge technology helps shops minimize downtime and maximize profits. For more information visit www.topdon.us

MTS-004 Poised to Fill an Unmet Need in the Treatment of Pseudobulbar Affect (PBA)

BEIJING, China, Oct. 23, 2025 /PRNewswire/ — METiS TechBio, a global leader in AI-driven nanodelivery and formulation innovation, today announced that its internally developed small-molecule candidate MTS-004 has successfully met the primary endpoint in its Phase III clinical trial. 

MTS-004 is China’s first drug candidate designed by AI-driven formulation technologies to complete Phase III development, and the first and only therapy for Pseudobulbar Affect (PBA) in the country to reach this milestone—representing a major step toward addressing an unmet clinical need in neurological disorders.

MTS-004 is a novel oral formulation designed for the treatment of PBA, utilizing METiS TechBio’s proprietary AiTEM platform to develop orally disintegrating tablet (ODT). Tailored for patients frequently experiencing dysphagia, MTS-004 dissolves rapidly in the mouth without the need for water, offering a pleasant taste and significantly improving medication adherence and patient experience.

Pseudobulbar Affect (PBA)—commonly known as “pathological laughing and crying”—is a neurological condition characterized by sudden, involuntary, and inappropriate episodes of laughing or crying that do not match a patient’s true emotional state. PBA frequently occurs secondary to central nervous system disorders such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, traumatic brain injury (TBI), or Parkinson’s disease (PD). The condition can severely impair social functioning and quality of life, while exacerbating the burden of underlying neurological diseases.

The AiTEM platform, powered by METiS TechBio’s proprietary NanoForge AI nanodelivery system, uses advanced algorithms to design and optimize pharmaceutical formulations. By integrating quantum chemistry and molecular dynamics simulations, AiTEM predicts drug–excipient interactions and generates nanoscale formulation optimization solutions to enhance solubility, bioavailability, and pharmacokinetic performance.

In the case of MTS-004, AiTEM enabled predictive modeling that shortened the preclinical formulation optimization period from the industry average of 1–2 years to under 3 months. From program initiation to Phase III completion, MTS-004 completed a full development cycle of in months, significantly accelerating the path from discovery to clinical validation.

The Phase III trial was led by Professor Dongsheng FAN, Chair of Neurology at the Peking University Third Hospital and a leading expert in ALS and neurodegenerative disorders. This randomized, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of MTS-004 in patients with PBA secondary to ALS, MS, stroke, TBI, or PD.

The trial enrolled 264 patients across 48 top-tier hospitals nationwide over a period of 9.5 months, including Beijing Xuanwu Hospital, Beijing Tiantan Hospital, West China Hospital Sichuan University, The First Affiliated Hospital of China Medical University, The Second Affiliated Hospital of Zhejiang University School of Medicine, Jiangsu Provincial People’s Hospital, Shandong Qianfoshan Hospital, Guangdong Second Provincial People’s Hospital, The First Affiliated Hospital of Zhengzhou University, Renji Hospital of Shanghai Jiao Tong University, and Xiangya Hospital of Central South University.

Currently, the only approved treatment worldwide for PBA is NUEDEXTA^® in the U.S. MTS-004, classified in China as a Category 2.2 improved new drug, introduces an innovative ODT formulation that effectively addresses swallowing difficulties—an unmet need among PBA patients—and provides a user-friendly alternative to capsule formulations.

Results from the Phase III study demonstrated that MTS-004 was safe, well-tolerated, and effective in reducing PBA symptoms in patients with neurological disorders. Therapeutic benefits were observable as early as week 2, with continued increases in symptom-free days and sustained improvement throughout the 12-week treatment period. MTS-004 achieved statistically significant improvements over placebo in: CNS-LS (Center for Neurologic Study–Lability Scale) total score, CGI-C (Clinical Global Impression of Change) and PGI-C (Patient Global Impression of Change), SF-36 Mental Health Index, reflecting enhanced emotional regulation and quality of life. Additionally, MTS-004 significantly improved CNS-BFS (Bulbar Function Scale) score, particularly in swallowing and drooling symptoms—critical complications in patients with motor neuron and central nervous system diseases.

MTS-004 is expected to submit a New Drug Application (NDA) to the National Medical Products Administration (NMPA) in 2026 for the PBA indication. Following approval, post-marketing studies are planned to explore potential label expansion for the treatment of dysphagia.

Professor Dongsheng FAN, Principal Investigator, commented:

“Artificial intelligence is reshaping how new drugs are discovered and developed. The MTS-004 clinical trial was challenging to initiate but was completed with outstanding quality. Its ability to improve patients‘quality of life—especially its clear impact on swallowing function—can reduce complications and may positively influence survival. While this study focused on ALS-related PBA, MTS-004 shows potential across broader neurological populations.“

Dr. Chris Lai, Co-founder and CEO of METiS TechBio, stated:

“We extend our sincere gratitude to Professor Fan, all participating investigators and clinical staff, every patient and family, and the community supporting PBA research. AI’s mission in medicine is to empower clinicians and race against diseases, driven by a deep understanding of unmet patient needs. That mission inspired our 38-month sprint from concept to Phase III completion. MTS-004 marks METiS TechBio’s first end-to-end success from discovery to late-stage clinical validation—a foundation that will accelerate every pipeline that follows.“

About METiS TechBio

Unlocking a healthier world through AI-driven nanotechnology. METiS Technologies is a pioneering TechBio company at the intersection of artificial intelligence and nanomaterial science, focused on transforming the delivery and application of active agents across life forms.

Founded by a team of MIT-trained scientists with deep expertise in AI, quantum mechanics, nanomaterials, and advanced drug delivery, the company has developed NanoForge, the world’s first AI-drive nano-delivery platform and three proprietary platform technologies, AiLNP – AI platform for nucleic acid delivery system design; AiRNA – AI platform for mRNA sequence optimization; and AiTEM – AI platform for small molecule formulation design.

METiS’ platforms simulate, predict, and interpret nanoscale interactions to enable rational design, optimization, and validation of next-generation nanomaterials and their payloads. By advancing AI-enabled nanotechnology, METiS strives to unlock new therapeutic possibilities across a wide range of diseases, including cancer, metabolic and autoimmune disorders, and neurodegenerative conditions, and improve the health of lives. 

SUZHOU, China, Oct. 23, 2025 /PRNewswire/ — Dreame Technology’s innovative Sparkling Water Refrigerator has been honored with the prestigious Japan Good Design Award, often called the “Oscar of Eastern Design.” The award recognizes its design philosophy of “Seamless Integration of Technology and Aesthetics,” marking a significant international endorsement of its innovative design and user experience.

The Dreame Sparkling Water Refrigerator goes beyond traditional home appliance design by integrating three core functions: Instant Sparkling Water, Smart Freshness, and Home Aesthetics. This integration offers a one-stop solution for modern kitchens. The refrigerator features an instant sparkling water system, supporting three levels of carbonation to meet various beverage pairing needs. The IceDUO Auto Ice Maker offers both cube ice and crushed ice, paired with a high-capacity ice box, easily catering to high-frequency household ice usage scenarios.

In terms of preservation, the refrigerator features a Twin-Cooling system that effectively prevents odor transfer. Its HumidFlex intelligent humidity control zone accurately maintains optimal humidity levels for various foods. The user-centric spatial design includes a dedicated snacks zone for canned goods and an adjustable wine rack, achieving a perfect balance of practicality and visual order.

The exterior utilizes an anti-fingerprint MatteSilk stainless steel panel. Combined with EU high energy efficiency certification and 35dB ultra-quiet operation, it realizes aesthetic expression while also adhering to concepts of energy saving and low noise for the home.

This award highlights Dreame’s leadership in product design and technology integration, accelerating its global expansion. Moving forward, Dreame will remain dedicated to user-centric innovation, pioneering a new era of smarter, more integrated high-end home appliances.

The article is from Shuzhi Society

NEW YORK, Oct. 23, 2025 /PRNewswire/ — MCO (MyComplianceOffice) has advanced to #42 in the 2026 Chartis RiskTech100, marking its third straight year of upward movement and another appearance among the world’s top 50 risk-technology providers.

The recognition reflects MCO’s continued momentum and innovation in delivering a unified platform that helps financial institutions manage compliance more effectively and with greater transparency.

“MCO is delighted to be recognized once again among the world’s foremost risk and compliance technology providers and to have moved still higher in the rankings,” said CEO Brian Fahey. “Our consistent trajectory demonstrates our ability to innovate, scale and deliver a unified, global compliance platform for our clients. We remain firmly focused on helping firms stay ahead of evolving regulatory demands with integrated, effective solutions.”

“Regulators and boards alike expect proof of effective oversight,” Fahey added. “We’re empowering compliance teams with technology that gives them both confidence and control — for today’s rules and tomorrow’s challenges.”

MCO’s ranking in the RiskTech100 underscores its growing global footprint and commitment to helping clients meet complex compliance demands.

“MyComplianceOffice’s inclusion in the RiskTech100 reflects its continued advances in third-party risk and compliance technology,” said Phil Mackenzie, Senior Research Principal at Chartis. “The firm has demonstrated a consistent ability to address evolving regulatory and operational requirements with integrated, data-led solutions, and its broad focus on holistic risk across the enterprise aligns well with an industry that is increasingly seeking a unified customer view.”

The Chartis RiskTech100^® is a comprehensive independent study of the world’s major players in risk and compliance technology. Rankings are based on functionality, core technology, strategy, customer satisfaction, market presence and innovation, and focus on solutions, industry segments and success factors.

MCO was also recently recognized by Chartis as a category leader in the 2025 Communications Monitoring and Enterprise GRC Solutions Quadrant reports and was included on the Chartis Financial Crime and Compliance50 ranking.

Read the full RiskTech100^® 2026 report here.

About MCO  

MCO (MyComplianceOffice) provides integrated compliance management software that enables global financial services firms to operate efficiently, ethically, and compliantly. With 30 products on a single system, the powerful MyComplianceOffice platform lets compliance professionals demonstrate that they are proactively managing compliance obligations and the regulated activities of employees, the company and third parties.   

1500+ client companies across 125+ countries use MyComplianceOffice to reduce the risk of misconduct and effectively oversee compliance obligations.

A fusion of art, AI, and playful learning brings warmth, imagination, and human connection into technology, showing how creativity turns everyday moments into inspiring experiences.

HONG KONG, Oct. 23, 2025 /PRNewswire/ — Infinix is exploring new ways for young consumers to connect with technology through its imaginative campaign “SMART Fruit Market” in Indonesia. The initiative turns daily life into a space for creativity, combining AI-generated artistry, interactive learning, and human-centered storytelling.

Based on insight into how young people experience technology, Infinix takes a different approach from traditional tech marketing by adding warmth, wit, and deeper consumer insights to its communications.

“The SMART Fruit Market reflects how Infinix blends cultural insight with creative imagination to craft storytelling with warmth and relevance,” said TT Liu, Chief Marketing Officer of Infinix. “We aim to use creativity, education, and interaction as bridges to bring technology closer to life, inspiring young people around the world to explore infinite possibilities for the future.”

A Creative Fusion of Art and Technology

Infinix unveiled a series of  AI-generated shorts that reimagine the perspectives of history’s most influential thinkers and artists, each portrayed in a distinct creative setting with their own playful “fruit-picking philosophy.” Through witty dialogue and visual metaphor, the shorts illustrate how everyday decisions can mirror the way consumers make smarter, value-driven technology choices.

Rule 1: “Color Makes Freshness Obvious.”
Rule 2: “High Prices Do Not Always Mean Higher Value.”
Rule 3: “You Need Greater Energy.”
Rule 4: “The Best Always Look Alike.”

Blending everyday humor with relatable insight, the campaign turns fruit-picking into a metaphor for mindful decision-making in technology. By connecting familiar life moments with creative storytelling, the shorts bridge art, science, and daily life—reflecting Infinix’s belief that technology should spark creativity, foster connection, and bring warmth to innovation.

Building on this idea, Infinix brought the concept offline through the SMART Fruit Market pop-up, where visitors experienced the four principles via interactive installations, learning zones, and themed photo spaces featuring the Infinix SMART 10 Plus.

The activation drew more than 8,000 visitors across Jakarta, Bandung, and Surabaya, generating strong engagement and positive audience feedback.

Humanizing Technology through Everyday Insight

Through consumer insight, Infinix found that young people seek innovation with a human touch. The brand moves beyond product-centric communication by weaving technology into daily life through storytelling that feels intuitive, emotional, and inspiring. 

This approach turns innovation into a human-centered experience, encouraging people to see technology not merely as a tool but as part of their lifestyle and creativity.

From Supermarket Aisles to Immersive Spaces

The campaign began in late September as a “Fruit Stall” activation inside Super Indo supermarkets in Jakarta. Among fresh-fruit displays, shoppers discovered smartphones accompanied by the same four playful selection principles, helping audiences evaluate technology with clarity and confidence.

Encouraged by the strong response, Infinix expanded the idea into a larger, immersive SMART Fruit Market pop-up. Participants joined the “Trade Your Apple” challenge for opportunities to win vouchers, merchandise, and the SMART 10 Plus smartphone—turning fruit picking into an interactive learning experience that linked technology with everyday culture.

“We turned a simple fruit-shopping idea into an interactive learning experience,” said Sergio Ticoalu, Head of Marketing, Infinix Indonesia. “This campaign connects technology to daily life and shows that making smart choices can be enjoyable.”

Continuing to Build Insight-Driven Creative Campaigns

Following the campaign’s success in Indonesia, Infinix will continue developing insight-driven creative strategies across global markets. Through collaborations with local communities and creative partners, the brand aims to create emotionally resonant experiences that bring warmth and inspiration to smart technology for consumers around the world.

About Infinix

Established in 2013, Infinix is an innovation-driven brand dedicated to delivering cutting-edge technology, bold design, and outstanding performance. The brand provides smart, enjoyable mobile experiences that enhance everyday life. Beyond smartphones, Infinix has expanded its portfolio to include TWS earbuds, smartwatches, laptops, tablets, smart TVs, and more—building a comprehensive ecosystem of smart devices. Currently, Infinix products are available in over 70 countries and regions worldwide, including Africa, Latin America, the Middle East, South Asia, and Southeast Asia.

For more information, please visit www.infinixmobility.com.