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A New Era in Cervical Cancer Elimination: INNOVAX Presents Global Progress with HPV 9-Valent Vaccine on IPVS 2025 Opening Day

BANGKOK, Thailand, Oct. 23, 2025 /PRNewswire/ — Xiamen Innovax Biotech Co., Ltd. (“INNOVAX”) participated in the 37th International Papillomavirus Society (IPVS) Conference, and hosted a dedicated symposium titled “A New Era of HPV Vaccines: The Efforts from Developing Country Manufacturers for Global Cervical Cancer Elimination” that stimulated significant discussion among attending global experts. Under the theme “Together Against HPV,” Innovax also welcomed visitors to Booth #09, engaging with scholars and potential partners.



 

The symposium was chaired by Dr. Wichai Termrungruanglert, Vice President of the Royal Thai College of Obstetricians. During the session, INNOVAX and Xiamen University jointly presented “Improving Global Equity in HPV Prevention: The Promise of a Novel E. coli-Expressed 9-Valent Vaccine.” Professor Ting Wu from Xiamen University presented, for 1st time to the international academic community, three-year follow-up data1 from a head-to-head clinical trial comparing Cecolin 9 with a marketed HPV 9-valent vaccine. The clinical results of Cecolin 9 demonstrate comparable immunogenicity and safety profiles to the marketed HPV 9-valent vaccine, underscoring its significant potential to improve equity in global HPV prevention.



Later was a presentation on “Together Against HPV: Leveraging Strong Partnerships for Cecolin 9 Local Production and Equitable Access in Thailand” by Dr. Nakorn Premsri, Director of the National Vaccine Institute of Thailand (NVI) and Dr. Boonrak Thawornrungroaj, Managing Director of Global Biotech Products Co., Ltd. (GBP). They detailed the localization strategy and implementation progress for Cecolin 9 in Thailand2.


The symposium was honored to host representatives from the Gates Foundation (GF), the Clinton Health Access Initiative (CHAI), Program for Appropriate Technology in Health (PATH), International Vaccine Institute (IVI) and experts from industries, etc.. Attendees spoke highly of Innovax’s significant contributions to advancing the global elimination of cervical cancer and expressed strong commitment to advancing the global cervical cancer elimination.

References:

1. Zhong GH, Bi ZH, Chu K, et al. Immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil9 in Chinese women aged 18–26 years: three-year follow-up data from a randomised clinical trial. The Lancet Regional Health – Western Pacific. 2025 Sep. 62: 101671. https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(25)00210-X/fulltext

2. Cecolin 9 is APPROVED by China NMPA and not currently available for sale or marketing in Thailand.

 

Please visit INNOVAX’s official website: https://www.xiameninnovax.com/, and follow us on LinkedIn (@Xiamen Innovax Biotech Co., Ltd.) and X (@Innovax).

The 40th Trade Expo Indonesia Officially Closes with Record-Breaking Results

Minister of Trade Budi Santoso: Transactions Surpass Target, Reaching USD 22.80 Billion

TANGERANG, Indonesia, Oct. 23, 2025 /PRNewswire/ — Minister of Trade Budi Santoso officially closed the 40th Trade Expo Indonesia (TEI) 2025 at the Indonesia Convention Exhibition (ICE), BSD, Tangerang Regency, Banten, on Sunday (19/10). As of 1:00 p.m. local time on the closing day, the country’s largest export exhibition recorded an outstanding achievement, with total transactions reaching USD 22.80 billion, equivalent to IDR 376.20 trillion, exceeding the initial target of USD 16.5 billion.

Minister of Trade Budi Santoso delivers a presentation on the results of the 40th Trade Expo Indonesia (TEI) 2025, highlighting total transactions of USD 22.8 billion over five days, exceeding the set target and marking a record achievement in Indonesia’s export performance.
Minister of Trade Budi Santoso delivers a presentation on the results of the 40th Trade Expo Indonesia (TEI) 2025, highlighting total transactions of USD 22.8 billion over five days, exceeding the set target and marking a record achievement in Indonesia’s export performance.

“As of 1:00 p.m. today, total transactions have reached USD 22.80 billion and are expected to continue growing beyond USD 23 billion. This achievement demonstrates that Indonesian products not only compete globally but have also become top choices in the international market. The 40th TEI highlights Indonesia’s natural and human resource strengths in producing high-quality and sustainable export products,” stated Minister Budi Santoso.

Throughout the five-day exhibition, TEI 2025 welcomed 34,550 visitors from 131 countries, surpassing the target of 30,000 visitors. Of these, 8,045 were international buyers representing 130 countries, with the largest contingents from Malaysia (769 buyers), China (605), India (594), Nigeria (509), and Egypt (406). The exhibition featured 1,619 participating companies, exceeding the target of 1,500. Participants included 623 companies in the Food, Beverages & Agricultural Products, Licensing and Franchise Zone; 603 companies in the Fashion & Lifestyle Zone; and 393 companies in the Manufacturing and Services Zone.

In terms of trade performance, goods transactions reached USD 17.90 billion, services USD 443.70 million, and investment USD 4.37 billion. These transactions comprised MoUs worth USD 22.70 billion, fairground transactions amounting to USD 71.60 million, and business matching deals worth USD 63.40 million, an 88% increase compared to 2024. Notably, micro, small, and medium enterprises (MSMEs) contributed USD 474.70 million (approximately IDR 7.80 trillion) in transactions.

Among participating countries, India led with USD 4.30 billion in transaction value, followed by the Netherlands (USD 3.90 billion), Vietnam (USD 3.30 billion), the Philippines (USD 3.10 billion), and China (USD 2.40 billion). The most sought-after products included mining products (USD 5.50 billion), precious metals (USD 2.70 billion), palm oil and derivatives (USD 2.30 billion), charcoal and briquettes (USD 1.60 billion), and spare parts (USD 1.40 billion).

In addition to the main exhibition, Pangan Nusa Expo 2025 also achieved notable success, generating USD 7.30 million in potential international culinary expansion deals, IDR 37.60 billion in business matching opportunities, and IDR 2.40 billion in on-the-spot transactions. The event provided market access for 12 culinary MSMEs, including winners of the UKM Pangan Award, to modern retail and national transportation networks such as PT KAI.

Minister Santoso extended his appreciation to all contributors, including trade representatives abroad, Trade Attachés (Atdag), Indonesia Trade Promotion Centers (ITPC), Indonesian Trade and Economic Offices (KDEI), Trade Consuls, and Ambassadors in partner countries. He also expressed gratitude to supporting ministries and agencies, PT Bank Mandiri (Persero), PT Debindo Multi Adhiswasti as the event organizer, and PT Pertamina along with the Badan Pengelola Dana Perkebunan (BPDP) as key partners.

“The success of the 40th TEI is the result of strong collaboration among the government, business community, banking sector, state-owned enterprises, and other strategic partners. Let us continue this momentum to further enhance the quality and competitiveness of Indonesia’s non-oil and gas exports,” Minister Santoso emphasized.

Minister Santoso also announced that the 41st Trade Expo Indonesia will be held from October 14–18, 2026, encouraging all stakeholders to pursue continuous innovation, improve product quality, harness digital technology, and uphold sustainable business practices.

“Keep innovating, elevate your product quality, and leverage digital technology. Stay passionate, the world awaits the finest products from Indonesia,” concluded Minister Santoso.

The 40th Trade Expo Indonesia is Organized by PT Debindomulti Adhiswasti.

PR Newswire is the media partner of the 40th Trade Expo Indonesia (TEI) 2025

 

 

The 40th Trade Expo Indonesia Officially Opens, Showcasing the Unlimited Excellence of Indonesian Products

TANGERANG, Indonesia, Oct. 23, 2025 /PRNewswire/ — Minister of Trade Budi Santoso, accompanied by Coordinating Minister for Food Affairs Zulkifli Hasan, officially inaugurated the 40th Trade Expo Indonesia (TEI) 2025 at the Indonesia Convention Exhibition (ICE) BSD City, Tangerang Regency, Banten, on Wednesday (15/10). The annual international-scale exhibition organized by the Ministry of Trade of the Republic of Indonesia carries the theme “Discover Indonesia’s Excellence: Trade Beyond Boundaries.”

Minister of Trade Budi Santoso delivers his keynote address during the opening ceremony of the 40th Trade Expo Indonesia (TEI) 2025. The event marks Indonesia’s ongoing commitment to strengthening global trade partnerships and showcasing the nation’s world-class export products.
Minister of Trade Budi Santoso delivers his keynote address during the opening ceremony of the 40th Trade Expo Indonesia (TEI) 2025. The event marks Indonesia’s ongoing commitment to strengthening global trade partnerships and showcasing the nation’s world-class export products.

In his remarks, Coordinating Minister Zulkifli Hasan, representing President Prabowo Subianto, emphasized that the government’s trade policies remain on the right track, as reflected in Indonesia’s strong and consistent export performance.

“As of this month, Indonesia’s national export value has grown by more than 7 percent compared to last year, with the trade surplus increasing to USD 29 billion. This remarkable achievement is the result of collective effort and collaboration. Through the spirit of partnership and optimism, Indonesia will continue to strengthen its position as a highly competitive economic power in the global market,” stated Minister Zulkifli Hasan.

Meanwhile, Minister of Trade Budi Santoso reported that TEI 2025 features 1,619 exhibitors and has successfully registered 8,045 buyers from 130 countries. The exhibition is divided into three main zones, Food & Agricultural Products, Manufacturing Products, and Services & Lifestyle, with total transaction targets reaching USD 16.5 billion.

“TEI serves as a tangible reflection of President Prabowo’s Asta Cita vision, reinforcing national downstream industrialization and expanding Indonesia’s role in the global value chain toward the Golden Indonesia 2045,” said Minister Santoso.

He added that beyond the main exhibition, the 40th TEI also features a series of supporting programs such as business matching, business counseling, and various business forums aimed at fostering partnerships and expanding global market access.

Minister Santoso extended his appreciation and gratitude to all stakeholders for their cooperation and support. Special acknowledgments were given to the Ministry of Foreign Affairs, Indonesian representatives abroad, foreign embassies in Indonesia, the Indonesian Chamber of Commerce and Industry (KADIN), and foreign chambers of commerce that actively contributed to engaging international buyers and expanding Indonesia’s trade network globally.

He also expressed appreciation to the main sponsors, Bank Mandiri, Pertamina, and the Palm Oil Plantation Fund Management Agency (BPDPKS) for their continuous support and participation in ensuring the success of the 40th TEI. Gratitude was also conveyed to all ministries and agencies, local governments, state-owned enterprises (SOEs), private partners, and PT Debindo Multi Adhiswasti as the event organizer for their valuable contributions.

“Through the spirit of collaboration and optimism that we build together, I am confident that Indonesia will continue to solidify its position as a highly competitive economic power in the global market for the prosperity of our nation and the well-being of the global community,” Minister Santoso concluded.

During the opening ceremony, Minister Santoso also presented the Primaniyarta Awards to top-performing exporters and regional leaders who have consistently increased their export value and global brand recognition. Awards were also given to pioneering exporters in new markets who serve as inspiration for Indonesia’s export community.

Additionally, the Primaduta Awards were presented to loyal buyers and Indonesia’s long-term export partners. The recognition also extended to Indonesian trade representatives abroad for their efforts in promoting the country’s non-oil and gas exports.

Distinguished guests attending the opening included Minister for Micro, Small, and Medium Enterprises (MSMEs) Maman Abdurrahman, Minister for Villages and Underdeveloped Regions Yandri Susanto, Governor of Banten Andra Soni, and Chairman of KADIN Indonesia Anindya Bakrie.

Also in attendance were Francisco Kalbuady Lay, Deputy Prime Minister and Coordinating Minister for Economic Affairs of the Democratic Republic of Timor-Leste; Salem Mohamed Ahmed Salman, Deputy Minister of Trade and Industry of Yemen; and Hossam Heiba, Chairman of the General Authority for Investment and Free Zones of Egypt; along with Indonesian ambassadors and foreign ambassadors from partner countries.

The 40th Trade Expo Indonesia is Organized by PT Debindomulti Adhiswasti.

PR Newswire is the media partner of the 40th Trade Expo Indonesia (TEI) 2025

 

Avaz Joins the PRC-Saltillo Community, Expanding Global AAC Access and Multilingual Innovation

SINGAPORE, Oct. 23, 2025 /PRNewswire/ — PRC-Saltillo, the parent company of PRC Saltillo Singapore, and a global leader in augmentative and alternative communication (AAC), is proud to announce that Avaz, known for its multilingual, design-forward AAC app, is now a wholly owned subsidiary of PRC-Saltillo. This strategic acquisition marks a significant milestone in PRC-Saltillo’s mission to expand access to AAC solutions worldwide.

  • Expanded AAC Portfolio: Avaz’s app joins PRC-Saltillo’s trusted suite of AAC solutions—including TouchChat®, LAMP Words for Life®, Dialogue® AAC, Unity® AAC, Accent®, NovaChat®, and Via®—offering new possibilities for users across diverse languages, communication needs, and operating systems.
  • Strengthened Global Presence: A newly incorporated entity in India enhances PRC-Saltillo’s ability to serve AAC users in India and Southeast Asia, regions where demand for communication support is rapidly growing.

A Shared Vision for Inclusive Communication
“This partnership reflects our shared belief that AAC is a right, not a privilege,” said Sarah Wilds, CEO of PRC-Saltillo. “PRC-Saltillo’s legacy is rooted in creating tools that address communication, language development, access, and implementation challenges. Avaz complements the belief that AAC is a right with its tech-integrated approach and deep understanding of multilingual user needs.”

Narayanan Ramakrishnan, CEO of Avaz, added, “Together, we’re uniquely positioned to expand access to AAC and share knowledge across borders. For both our customers and our internal teams, this means new opportunities to learn, innovate, and grow together.”

Customer Continuity and Support
All employees across Avaz and PRC-Saltillo’s global subsidiaries will remain in their roles, and customers can expect uninterrupted access to both Avaz and PRC-Saltillo devices, apps, services, and support. There are currently no plans for the prices, availability, or content of the Avaz and PRC-Saltillo apps to change. Both companies remain committed to the quality and care their customers trust.

ABOUT PRC-SALTILLO: Founded in 1966, PRC-Saltillo is a pioneer and global leader in providing augmentative and alternative communication (AAC) technology to individuals with complex communication disorders. PRC-Saltillo offers a full range of speech-generating devices, industry-favorite AAC apps, and research-based vocabulary systems along with unmatched support and training. PRC-Saltillo is a 100% employee-owned company and headquartered in Wooster, Ohio with subsidiaries in the United Kingdom, Canada, Australia, Germany, Singapore, and India.

ABOUT AVAZ INC: Avaz Inc. is a global assistive technology company dedicated to making every voice heard. Its flagship product, Avaz AAC, is a picture and text-based communication app that empowers children and adults with complex communication needs such as Autism, Cerebral Palsy, Down Syndrome, and Aphasia to express themselves with confidence. With availability in 15+ languages across 100+ countries, Avaz is trusted by families, schools, and therapists for its intuitive design, multilingual support, and evidence-based approach. Beyond technology, Avaz supports the entire ecosystem – parents, educators, and speech-language professionals through training, resources, and communities that make communication accessible for all. Created in 2009, Avaz has impacted over 200,000 lives worldwide, enabling independence, inclusion, and meaningful connections.

Logo –  https://laotiantimes.com/wp-content/uploads/2025/10/prc_saltillo_logo.jpg
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Global Times: Opening up new prospects amid changing circumstances

BEIJING, Oct. 23, 2025 /PRNewswire/ — With a year-on-year growth rate of 5.2 percent, China’s economy has maintained an overall stable development trajectory with steady progress in the first three quarters of this year.

This hard-won rate of 5.2 percent has demonstrated the stability and resilience of the Chinese economy, which enhances the country’s confidence and resolve to overcome difficulties. And the new development philosophy plays a key role in this.

The tide of the times is surging, outlining the magnificent trajectory of China’s economy. As global changes unseen in a century are rapidly evolving and challenges from external headwinds and internal transitions are interwoven, a profound shift in mindset is now shaping the future of China’s economy with formidable strength.

President Xi Jinping said that the China of today stands at a new historical starting point in development. “In light of development requirements in the new stage, we need to stick to a problem-oriented approach so that we can implement the new development philosophy with even greater precision. We need to effectively address the issues relating to unbalanced and insufficient development in order to make our development high-quality,” Xi, also general secretary of the Communist Party of China Central Committee and chairman of the Central Military Commission, said, according to Qiushi Journal.

The new development philosophy features innovative, coordinated, green, open and shared development, is the “ballast stone” and “power source” for the Chinese economic ship to create new opportunities in crises and open up new prospects in changing circumstances, and has demonstrated strong vitality and resilience on the path of high-quality development.

The more magnificent the journey, the more it requires the strength of stewardship.

High-quality development is an intrinsic requirement of Chinese modernization. Under the scientific guidance of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era, especially Xi Jinping Thought on Economy, and by fully, accurately and comprehensively implementing the new development philosophy and accelerating the building of a new development paradigm, China’s economy will surely stride forward on the path of higher quality, more efficient, fairer, more sustainable and safer development.

Innovation

In today’s world, whoever holds the leading spot of scientific and technological innovation and takes the first step in scientific and technological innovation will seize the initiative and gain an advantage. The key to Chinese modernization lies in scientific and technological modernization. China must leverage scientific and technological innovation, develop new quality productive forces in light of local conditions and strengthen the support capacity of the modern industrial system for high-quality development.

The breakthrough in chip technology epitomizes how sci-tech innovation, as a pivotal variable, is accelerating its transformation into the “largest increment” for high-quality development.

In a lab of Chinese chipmaker New Sonic Technologies in Shenzhen, South China’s Guangdong Province, technicians are holding their breath and intently watching the waveforms jumping on the test system. They’re working on the high-end radio frequency (RF) filter – a “micron-level device” crucial for 5G communications and smart terminals.

“On a film just a few microns thick, we engrave tracks that can precisely guide sound waves while ensuring stability under extreme conditions,” the company’s founder Zou Jie said. The company started research and development (R&D) on the high-end RF filter technology four years ago, at a time when the device were almost 100 percent relying on imports.

The breakthrough came from technological self-reliance and self-improvement. Every year, the company invests over 100 million yuan ($14.1 million) in R&D. Simulation, tape-out, testing, analysis – the entire laboratory erupts in excitement when the self-developed filter surpasses foreign peers in multiple core performance metrics.

The breakthrough also is attributed to the company’s close collaboration with upstream wafer fabs and downstream packaging plants, during which they jointly process debugging and collaborative structural optimization. Now, this hard-won “Chinese chip” has been widely adopted by leading smartphone and tablet brands, ranking among the top in domestic market shipments.

A strong industrial sector also makes a strong economy. The modern industrial system forms the material and technological foundation of a modern nation, while its innovation ecosystem serves as the core engine. While traditional industries are accelerating their transition toward high-end, smart, and green development, China’s emerging and future industries are also flourishing and expanding vigorously. The new landscape has significantly enhanced the resilience and security of industrial and supply chains.

Today, China invests over 3.6 trillion yuan in R&D, maintaining its position as the world’s second-largest R&D spender. The country has climbed to the 10th place in the Global Innovation Index and is now home to more than 140,000 specialized and sophisticated small and medium-sized enterprises that produce new and unique products.

Greenness

The green and low-carbon transition represents the trend of our times, while green development defines the undertone of high-quality development. The fundamental approach to achieving sustainable growth is to establish an economic system that promotes green and low-carbon development and foster a comprehensive green transformation in economic and social development.

In the Kubuqi Desert of North China’s Inner Mongolia Autonomous Region, millions of photovoltaic panels converge into a “sea of energy.” The green electricity generated by the “sea,” which is transmitted through ultra-high-voltage power grids across mountains and rivers, lights up millions of homes in eastern city clusters thousands of kilometers away.

China’s photovoltaic industry suffered a big hit several years ago due to a sudden international trade barrier, which froze the industry with orders plummeting and inventories soaring.

Recalling the situation, Liu Qiang, general manager of photovoltaic module producer Eging PV, said that “either perish in adversity or be reborn under pressure.”

Chinese photovoltaic industry has obviously chosen the latter and embarked a journey of “turning crisis into opportunity.” The development was not only about survival but also a pressing self-evolution driven by the urgent need for sustainable development.

For example, with regards to upstream, polysilicon producers in western China have been leveraging abundant green electricity resources and technological innovation to minimize energy consumption in production, so as to build green and low-cost competitive advantages from the source.

In midstream, solar panel manufacturers in eastern China have been joining force to collaboratively make breakthrough in next-generation high-efficiency battery technology. Downstream players have also expanded the use of green energy as a way to significantly reduce energy costs for businesses.

The result of this “stress test” is very impressive. To date, China’s photovoltaic industry chain has been reshaped through collaboration, gradually forming a multi-point supported and more resilient supply chain system. Meanwhile, a full set of technology, standard and service involving the industry has successfully expanded globally, becoming an oasis and lighthouse for sustainable development in the new era.

A flurry of data underscores this transformation. China now provides over 80 percent of the world’s photovoltaic modules and 70 percent of wind power equipment. During the 14th Five-Year Plan (2021-25) period, China’s exports of wind and solar products cumulatively reduced carbon emissions for other countries by approximately 4.1 billion tons.

Openness

South China’s Hainan Province opens a new window for the mutual promotion of China’s dual circulation. The Hainan Free Trade Port (FTP) will officially launch an island-wide independent customs operation on December 18 this year.

“In the past, I had to wait for overseas purchases or find opportunities to go abroad to buy new cosmetic products. Now, I can simply purchase a ticket and fly to Hainan, where prices of those products are also cost effective,” said Zhang Lu, a Chinese traveler who was shopping at the duty-free shop at the Haikou Meilan International Airport in Hainan.

Zhang’s change in experience is a vivid footnote to how China activates its super-large domestic market through high-level opening-up. Hainan’s duty-free policy represents a highly valuable institutional opening-up measure. The policy firmly “draws back” the massive outbound consumption power, playing a symphony of the new development paradigm. It also draws in more world-leading brands, driving prosperity across local tourism, hospitality, logistics, and a hundred other industries, while creating numerous job opportunities.

The trajectory of the FTP’s development embodies the vision of a great nation. Facing headwinds and backlashes in economic globalization, China’s door to opening-up will not close; it will only open wider. And a more open China will undoubtedly bring more opportunities to the world and, through exchanges with the world, shape greater resilience and vitality for its own high-quality development.

To date, China has completely eliminated foreign investment access restrictions in the manufacturing sector, while opening-up in the service sector is advancing steadily. As of the end of June, the actual foreign investment utilized in China during the 14th Five-Year Plan (2021-25) period has reached $708.73 billion and the country has established 22 free trade zones.

A series of pragmatic measures to expand opening-up have won widespread praise from the international community and the “vote with their feet” by multinational companies, who believe that “believing in China is believing in a better tomorrow.”

TOPDON US Innovates RLink J2534 with More Robust Technology, Features for Increased Application and Flexibility

ROCKAWAY, N.J., Oct. 23, 2025 /PRNewswire/ — TOPDON US (https://www.topdon.us/) has innovated two of the company’s most popular products, the RLink J2534 (https://www.topdon.us/products/rlink-j2534) and TopScan (https://www.topdon.us/products/topscan) with more robust technology and features for greater use and flexibility. Developed using customer feedback, the RLink J2534 now offers the diagnostic capabilities of the TopScan in addition to its robust programming and coding functionality. RLink J2534 and RLink X7 owners now get one year of the TopScan app access free (a $99 value). The newly innovated RLink J2534 is now available through TOPDON’s national distribution network.

TOPDON RLink J2534
TOPDON RLink J2534

“We go to great lengths to listen to our customer feedback,” said Chad Schnitz, Vice President of TOPDON US. “Our customers use our products every day, so their feedback is critical in helping us identify opportunities for improvement. Every enhancement we deliver, like the updates made to the RLink J2534, are a direct reflection of the insights our customers share with us.”

Now available with TopScan software that performs all 10 modes of OBD2 testing, the RLink J2534 is one of the most cost-effective programming and diagnostic tools on the market. Through the Topscan software integration, it offers instant access to crucial information for thousands of vehicles while also fully supporting all J2534 protocols, ensuring compatibility with OEM reprogramming and diagnostic functions.

“The enhancements we’ve made to the RLink J2534 ensure it will continue to deliver real value and adapt to our customers evolving needs,” said Schnitz. “Over the last eight years in the North American market, TOPDON has constantly sought a higher standard of performance, at a price point that doesn’t break the bank. The improvements we’ve made to the RLink J2534 are evidence of the trust we have in our customers and how we are leading in a rapidly changing marketplace.”

About TOPDON US
Founded in 2017 and based in Rockaway, New Jersey, TOPDON US is a provider of entry-level, mid-level, and advanced tools and solutions for professional technicians, as well as DIY enthusiasts. Globally, TOPDON has over 250 industry-leading engineers and owns over 500 patents and software copyrights. The company’s cutting-edge technology helps shops minimize downtime and maximize profits. For more information visit www.topdon.us

METiS BioTech announces China’s First AI-Enabled Formulation Drug Candidate to Complete Phase III Clinical Trial

MTS-004 Poised to Fill an Unmet Need in the Treatment of Pseudobulbar Affect (PBA)

BEIJING, China, Oct. 23, 2025 /PRNewswire/ — METiS TechBio, a global leader in AI-driven nanodelivery and formulation innovation, today announced that its internally developed small-molecule candidate MTS-004 has successfully met the primary endpoint in its Phase III clinical trial. 

MTS-004 is China’s first drug candidate designed by AI-driven formulation technologies to complete Phase III development, and the first and only therapy for Pseudobulbar Affect (PBA) in the country to reach this milestone—representing a major step toward addressing an unmet clinical need in neurological disorders.

MTS-004 is a novel oral formulation designed for the treatment of PBA, utilizing METiS TechBio’s proprietary AiTEM platform to develop orally disintegrating tablet (ODT). Tailored for patients frequently experiencing dysphagia, MTS-004 dissolves rapidly in the mouth without the need for water, offering a pleasant taste and significantly improving medication adherence and patient experience.

Pseudobulbar Affect (PBA)—commonly known as “pathological laughing and crying”—is a neurological condition characterized by sudden, involuntary, and inappropriate episodes of laughing or crying that do not match a patient’s true emotional state. PBA frequently occurs secondary to central nervous system disorders such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, traumatic brain injury (TBI), or Parkinson’s disease (PD). The condition can severely impair social functioning and quality of life, while exacerbating the burden of underlying neurological diseases.

The AiTEM platform, powered by METiS TechBio’s proprietary NanoForge AI nanodelivery system, uses advanced algorithms to design and optimize pharmaceutical formulations. By integrating quantum chemistry and molecular dynamics simulations, AiTEM predicts drug–excipient interactions and generates nanoscale formulation optimization solutions to enhance solubility, bioavailability, and pharmacokinetic performance.

In the case of MTS-004, AiTEM enabled predictive modeling that shortened the preclinical formulation optimization period from the industry average of 1–2 years to under 3 months. From program initiation to Phase III completion, MTS-004 completed a full development cycle of in months, significantly accelerating the path from discovery to clinical validation.

The Phase III trial was led by Professor Dongsheng FAN, Chair of Neurology at the Peking University Third Hospital and a leading expert in ALS and neurodegenerative disorders. This randomized, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of MTS-004 in patients with PBA secondary to ALS, MS, stroke, TBI, or PD.

The trial enrolled 264 patients across 48 top-tier hospitals nationwide over a period of 9.5 months, including Beijing Xuanwu Hospital, Beijing Tiantan Hospital, West China Hospital Sichuan University, The First Affiliated Hospital of China Medical University, The Second Affiliated Hospital of Zhejiang University School of Medicine, Jiangsu Provincial People’s Hospital, Shandong Qianfoshan Hospital, Guangdong Second Provincial People’s Hospital, The First Affiliated Hospital of Zhengzhou University, Renji Hospital of Shanghai Jiao Tong University, and Xiangya Hospital of Central South University.

Currently, the only approved treatment worldwide for PBA is NUEDEXTA® in the U.S. MTS-004, classified in China as a Category 2.2 improved new drug, introduces an innovative ODT formulation that effectively addresses swallowing difficulties—an unmet need among PBA patients—and provides a user-friendly alternative to capsule formulations.

Results from the Phase III study demonstrated that MTS-004 was safe, well-tolerated, and effective in reducing PBA symptoms in patients with neurological disorders. Therapeutic benefits were observable as early as week 2, with continued increases in symptom-free days and sustained improvement throughout the 12-week treatment period. MTS-004 achieved statistically significant improvements over placebo in: CNS-LS (Center for Neurologic Study–Lability Scale) total score, CGI-C (Clinical Global Impression of Change) and PGI-C (Patient Global Impression of Change), SF-36 Mental Health Index, reflecting enhanced emotional regulation and quality of life. Additionally, MTS-004 significantly improved CNS-BFS (Bulbar Function Scale) score, particularly in swallowing and drooling symptoms—critical complications in patients with motor neuron and central nervous system diseases.

MTS-004 is expected to submit a New Drug Application (NDA) to the National Medical Products Administration (NMPA) in 2026 for the PBA indication. Following approval, post-marketing studies are planned to explore potential label expansion for the treatment of dysphagia.

Professor Dongsheng FAN, Principal Investigator, commented:

“Artificial intelligence is reshaping how new drugs are discovered and developed. The MTS-004 clinical trial was challenging to initiate but was completed with outstanding quality. Its ability to improve patients‘quality of life—especially its clear impact on swallowing function—can reduce complications and may positively influence survival. While this study focused on ALS-related PBA, MTS-004 shows potential across broader neurological populations.“

Dr. Chris Lai, Co-founder and CEO of METiS TechBio, stated:

“We extend our sincere gratitude to Professor Fan, all participating investigators and clinical staff, every patient and family, and the community supporting PBA research. AI’s mission in medicine is to empower clinicians and race against diseases, driven by a deep understanding of unmet patient needs. That mission inspired our 38-month sprint from concept to Phase III completion. MTS-004 marks METiS TechBio’s first end-to-end success from discovery to late-stage clinical validation—a foundation that will accelerate every pipeline that follows.“

About METiS TechBio

Unlocking a healthier world through AI-driven nanotechnology. METiS Technologies is a pioneering TechBio company at the intersection of artificial intelligence and nanomaterial science, focused on transforming the delivery and application of active agents across life forms.

Founded by a team of MIT-trained scientists with deep expertise in AI, quantum mechanics, nanomaterials, and advanced drug delivery, the company has developed NanoForge, the world’s first AI-drive nano-delivery platform and three proprietary platform technologies, AiLNP – AI platform for nucleic acid delivery system design; AiRNA – AI platform for mRNA sequence optimization; and AiTEM – AI platform for small molecule formulation design.

METiS’ platforms simulate, predict, and interpret nanoscale interactions to enable rational design, optimization, and validation of next-generation nanomaterials and their payloads. By advancing AI-enabled nanotechnology, METiS strives to unlock new therapeutic possibilities across a wide range of diseases, including cancer, metabolic and autoimmune disorders, and neurodegenerative conditions, and improve the health of lives. 

Dreame’s Sparkling Water Refrigerator Honored with Japan Good Design Award

SUZHOU, China, Oct. 23, 2025 /PRNewswire/ — Dreame Technology’s innovative Sparkling Water Refrigerator has been honored with the prestigious Japan Good Design Award, often called the “Oscar of Eastern Design.” The award recognizes its design philosophy of “Seamless Integration of Technology and Aesthetics,” marking a significant international endorsement of its innovative design and user experience.

Dreame's Sparkling Water Refrigerator Honored with Japan Good Design Award
Dreame’s Sparkling Water Refrigerator Honored with Japan Good Design Award

The Dreame Sparkling Water Refrigerator goes beyond traditional home appliance design by integrating three core functions: Instant Sparkling Water, Smart Freshness, and Home Aesthetics. This integration offers a one-stop solution for modern kitchens. The refrigerator features an instant sparkling water system, supporting three levels of carbonation to meet various beverage pairing needs. The IceDUO Auto Ice Maker offers both cube ice and crushed ice, paired with a high-capacity ice box, easily catering to high-frequency household ice usage scenarios.

In terms of preservation, the refrigerator features a Twin-Cooling system that effectively prevents odor transfer. Its HumidFlex intelligent humidity control zone accurately maintains optimal humidity levels for various foods. The user-centric spatial design includes a dedicated snacks zone for canned goods and an adjustable wine rack, achieving a perfect balance of practicality and visual order.

The exterior utilizes an anti-fingerprint MatteSilk stainless steel panel. Combined with EU high energy efficiency certification and 35dB ultra-quiet operation, it realizes aesthetic expression while also adhering to concepts of energy saving and low noise for the home.

This award highlights Dreame’s leadership in product design and technology integration, accelerating its global expansion. Moving forward, Dreame will remain dedicated to user-centric innovation, pioneering a new era of smarter, more integrated high-end home appliances.

The article is from Shuzhi Society