Thailand’s Constitutional Court has ordered Prime Minister Prayut Chan-o-cha to temporarily cease his official duties until the court can review the legality of his eight-year term limit.
Hong Kong Baptist University scientists develop versatile compound for treating Alzheimer’s disease

AD is the most common cause of dementia. It accounts for nearly 65% of dementia cases in elderly Hong Kong Chinese. It is pathologically characterised by the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerve cells in the brain, which cause progressive neuronal loss and cognitive impairment. Currently there is no cure for AD, and the available medicines can only relieve its symptoms. Inhibiting the abnormal aggregation of Aβ and the hyperphosphorylation of tau proteins is considered the primary and a promising therapeutic approach to treat AD.
F-SLOH as theragnostic agent for AD
In the search for novel therapeutic and diagnostic methods for AD, a research team comprising Professor Li Min, Professor of the Teaching and Research Division and Associate Dean of the School of Chinese Medicine; Professor Ricky Wong Man-shing, Professor of the Department of Chemistry of the Faculty of Science; and Dr Iyaswamy Ashok, Research Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine at HKBU, demonstrated the in vivo therapeutic efficacy of a compound called F-SLOH in reducing the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerves cells in the brain, thereby improving the learning and memory functions of mice with AD.
F-SLOH is a multi-functional cyanine probe synthesised by a team led by Professor Ricky Wong Man-shing for the detection of biological materials such as proteins and peptides. Its features include real-time visualisation of Aβ aggregation in brains, excellent permeability across the blood-brain barrier and low bio-toxicity. Previous studies showed that F-SLOH could inhibit the abnormal aggregation of Aβ species and provide neuroprotection against neurotoxicity induced by the abnormal aggregation of Aβ in vitro at the cellular level.
F-SLOH improves pathological features in AD mice
To determine the therapeutic efficacy of F-SLOH for AD, the researchers injected or fed F-SLOH to a group of transgenic AD mice. Histopathology and biochemical analyses showed that in mice treated with F-SLOH, Aβ oligomers (one of the Aβ species) and Aβ plaque deposits (the clumps of Aβ) were dramatically reduced in their hippocampus and their brains when compared with the AD mice in the control group who had not been fed F-SLOH.
The researchers also found that F-SLOH can reduce the levels of an amyloid precursor protein that generates Aβ and tau protein hyperphosphorylation. In an immunoblot analysis of the transgenic AD mice brian, the F-SLOH treatment group showed a significant reduction in the levels of the amyloid precursor protein and its metabolites compared to the control group.
In other experiments on the transgenic AD mice after F-SLOH treatment, the researchers separated the soluble and insoluble tau proteins in their brain tissue samples. The results showed that F-SLOH treatment significantly reduced the levels of insoluble tau protein in the brains of AD mice, which forms neurofibrillary tangles, one of the pathological features of AD.
F-SLOH improves memory and cognitive functions in AD mice
Aggregation of Aβ is closely related to the dysfunction of the links between nerve cells and memory decline. The researchers conducted two experiments to test the memory functions of AD mice. In the first experiment, mice were trained to swim in a water maze, reach a platform and remember its position. After the platform was removed, researchers observed whether the mice were able to recall and approach the original position of the platform. Compared to the control group, transgenic AD mice treated with F-SLOH spent more time swimming around the platform’s original position, showing that they can better memorise the platform’s location.
In the second experiment, mice were placed in a chamber and exposed to an audio tone followed by an instant small electric shock to their feet from the floor of the chamber. On the following day, they were put back in the chamber but without any electric shock. When the mice were exposed to the same audio tone, they “froze” their body movements due to the fear of an electric shock. The transgenic AD mice treated with F-SLOH exhibited a longer freezing time than that of the control group.
The results of the two experiments showed that AD mice treated with F-SLOH have better memories compared to the control group, suggesting that F-SLOH improved AD mice’s memory and cognitive functions.
F-SLOH shows early potential for treating AD
The researchers also revealed that F-SLOH degraded the abnormal aggregation of Aβ and reduced the levels of tau protein hyperphosphorylation, the amyloid precursor protein and its metabolites through the activation of the transcription factor EB. Transcription factor EB is the main regulator of the autophagy-lysosomal pathway, a major mechanism for degrading ageing intracellular macromolecular proteins, including the intracellular metabolites such as Aβ aggregates.
Professor Li Min said: “AD patients lose their self-management abilities and require long-term care as the disease progresses. As the population is ageing in Hong Kong, the prevalence of AD is likely to increase. There is an urgent need to develop new drugs that can treat or slow down the progression of AD. The current study suggests that the compound F-SLOH has promising theragnostic potential for treating AD at an early stage.”
Professor Ricky Wong Man-shing said: “The study provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. The research findings can drive advancements in AD diagnosis and treatment in humans.”
Hashtag: #HongKongBaptistUniversity #HKBU
Traveloka supports Indonesia’s digital transformation acceleration through the G20 DEWG
- As the coordinator of the Digital Economy Working Group (DEWG) Industry Task Force (ITF) in the G20 Indonesia 2022 Presidency, Traveloka is helping the Indonesia government in realizing an inclusive, and sustainable digital transformation.
- Through this initiative, Traveloka has undertaken various programs to upskill digital talents and strengthen the ecosystem in the tourism industry.
JAKARTA, INDONESIA- Media OutReach – 24 August 2022 – Digitization drives tremendous benefits by offering new economic growth opportunities across various sectors, including the tourism industry. According to Google, Temasek, and Bain & Company’s e-Conomy SEA 2021 report, the pandemic has generated up to 21 million new digital customers between 2020 and the first half of 2021. Digital activity in 2020 showed that Indonesia’s digital economy gross domestic product (GDP) surged 11%[1], while its tourism sector showed a good performance in the beginning of 2022, and is expected to grow up to 4.3% from 4.2%[2] in 2021.

Carrying the theme, “Recover Together, Recover Stronger”, the G20 Indonesia 2022 Presidency will seize the momentum to establish a sustainable and inclusive transformation while exploring new avenues to shape a more adaptive G20 against future crises. Focused on economic recovery through increased digital utilization, the Ministry of Communications and Informatics (Kominfo) is collaborating with 40 digital platform providers in Indonesia, collectively named the Industry Task Force (ITF), under the G20 Digital Economy Working Group (DEWG). This collaboration aims to contribute to the success of digital economy discussions toward an inclusive, and sustainable digital ecosystem.
“The G20 DEWG aspires to achieve digital transformation to generate added value in each sector supporting Indonesia’s national economy. Based on a Kominfo survey, conducted in collaboration with the Indonesia Internet Service Provider Association (APJII), 77% of Indonesians utilize the Internet for more than eight hours daily. Considering that digital adoption has become an integral part of daily lives, the optimization of digital skills and literacy is crucial. In addition, the continued partnership with the private sector is crucial in building a stronger economy foundation in our digital transformation efforts,” stated Mira Tayyiba, Secretary-General for the Indonesia Ministry of Communications and Informatics and Chair of G20 DEWG, during the G20 Digital Economy Working Group Industry Task Force Indonesia 2022 media discussion that was conducted on Friday, 19 August 2022.
Themed “Establishing Digital Ecosystem Synergy for Post-Pandemic Global Recovery“, the three priorities of this discussion are connectivity and post-pandemic recovery, digital skills and literacy, as well as cross-border data flows. The DEWG also invited experts to discuss the economic aspect in the three priorities and its alignment toward digital transformation and national economic growth.
Southeast Asia’s travel and lifestyle platform, Traveloka, was appointed by the Ministry of Communications and Informatics as the coordinator of G20 DEWG ITF 2022. As a technology company, Traveloka believes in the importance of synergy across sectors, and is committed to supporting the government in its efforts to increase digital literacy and talents in the country. This can be realized by encouraging industry players to adopt technology, in order to extend their service access, as well as support their businesses.
Widyasari Listyowulan, Vice President of Public Policy & Government Relations, Traveloka said, “We believe that collaboration in an inclusive, sustainable, and empowering digital ecosystem is the driving force for Indonesia’s post-pandemic economic recovery. Thus, through Traveloka’s involvement in the DEWG ITF, we actively coordinate discussions and strong partnerships between industry players to accelerate the nation’s digital transformation and economic recovery. Digital platforms enable an extended and simplified access for the ecosystem, including Traveloka’s partners and customers. Traveloka is committed to provide comprehensive end-to-end solutions to fulfill Indonesia’s travel and lifestyle needs, as well as contribute to the tourism ecosystem in collaboration with our partners and SMEs in Indonesia.”
Yose Rizal Damuri, Executive Director, Centre for Strategic and International Studies (CSIS) said, “The pandemic has become the momentum of change for Indonesia. In the past two years, digitization grew rapidly, forcing digital adoption across the country. It also changed the operational landscape across economic sectors. While the surge of digital utilization brings recovery and growth opportunities for Indonesia’s economy, there are many aspects that require further optimization, such as infrastructure, human resources and users’ literacy. This initiative led by the Ministry of Communications and Informatics and Traveloka through G20 DEWG ITF Indonesia 2022 encourages the collaboration between government, industry players, and the public through the extension of digital infrastructure, utilization, and also various forms of training and empowerment for the public and SMEs that will be the enabler for Indonesia’s economic recovery acceleration.”
As the coordinator of ITF, Traveloka actively encourages fellow digital platform players to accelerate digital literacy and talents through a series of G20 DEWG 2022 activities in the form of seminars on economy education, as well as the Digital Talent Scholarship program. This is a skills-training program for students at various levels of education, which is initiated by Kominfo. Moreover, to encourage the development of digital talent that is required by the industries, Traveloka has recently collaborated with Monash University in presenting MITRA 5.0, a knowledge sharing program to improve educators’ digital skills and capabilities.
“We are making continuous efforts to drive and distribute an even national economic recovery, through optimized digital transformation. With the support of all G20 DEWG ITF members, we will build a strong, sustainable, and inclusive digital economy in Indonesia together,” added Listyowulan.
The DEWG will continue its fourth meeting in Bali on August 28-30, 2022. During this meeting, G20 DEWG ITF will showcase Indonesia’s digital ecosystem to all delegates of the G20 member countries. G20 DEWG ITF members will also be attending the Digital Innovation Network, to share knowledge and insights in today’s post-pandemic economic recovery to the delegates of G20.
Hashtag: #Traveloka
About Traveloka
Traveloka, Southeast Asia’s travel and lifestyle platform, provides users access to discover and purchase a wide range of travel, local services, and financial services products. Traveloka’s comprehensive product portfolio includes transport booking services such as flight tickets, bus, trains, car rental, airport transfer, as well as access to the largest accommodation inventory in Southeast Asia, including hotels, apartments, guest houses, homestays, resorts, and villas, making Traveloka a booking platform with the widest selection of accommodation and packages.
Traveloka is also a key player in the local services category (currently specific to certain markets), offering reservations for a wide range of local attractions, activities, wellness and beauty clinics, culinary directories as well as food delivery. Traveloka also offers financing, payment, and insurance products to help Southeast Asian consumers fulfill their lifestyle aspirations. Traveloka provides 24/7 customer service in local languages as well as more than 30 different local payment methods. Traveloka travel and lifestyle platform has been downloaded more than 100 million times, making it the most popular travel and lifestyle booking application in the Southeast Asian region.
G2E Asia 2022, Special Edition: Singapore Reunites the Asian Gaming Industry
Special Edition Marks In-Person Return of G2E Asia
SINGAPORE – Media OutReach – 24 August 2022 – Global Gaming Expo (G2E) Asia will convene in-person for the first time since 2019 with the opening of the special edition in Singapore today. From August 24-26 at the Marina Bay Sands, more than 70 exhibitors and thousands of attendees from around the region will reconnect, network, and conduct business to propel the industry forward.
“G2E Asia is where the future of Asian gaming is defined. We are excited to bring the industry together once again and encouraged by the tremendous response from exhibitors and attendees to convene in Singapore,” said Chien Ee Yeh, President of APAC, Reed Exhibitions.
G2E Asia 2022, Special Edition: Singapore will feature content on the latest market trends, innovative products, and regulatory requirements and networking with technology specialists, investors, regulators, and top leaders in the field. On-site highlights include:
- The new Smart IR and Innovation Zone will demonstrate new products and solutions that help professionals to get first-hand information to operate more effectively in the new landscape.
- The Esports Connect Asia Regulatory Workshop is open to qualified attendees, targeting the regulatory and legal fields. Experts will share their knowledge and experiences on the challenges and opportunities in the regulation of esports and video games for consumer protection and economic development.
- The Future IR Tech Talk Forum features top industry expert talks on exciting innovations and product launches to drive business growth in different aspects of integrated resorts that include data analytics, cloud solutions, payment solutions, and marketing.
- The G2E Asia Conference Program returns for three content-rich days of sessions and forums led by high-level industry leaders, influencers, and experts. Highlights:
- o A keynote from Ed Bowers, President of Global Development for MGM Resorts International and President & CEO of MGM Resorts Japan
- o An in-depth look at the financial outlook for Asian gaming destinations as well as Asia’s integrated resorts in terms of regulation and future development opportunities.
- o Themes focused on What’s Next for Gaming and Entertainment in Asia, Win with Transformation, and Leveraging Innovation and Technology.
Segmented Industry Networking including the Table Games Networking Cocktails, Slots Networking Cocktails, eSports Networking Cocktails, and Future IR Technology Leaders Networking Cocktails.
To learn more about G2E Asia, visit www.g2easia.com.
Hashtag: #G2EAsia #G2EAsiaSingapore #Aug24-26 #MarinaBaySands
ABOUT G2E ASIA
G2E Asia is the international gaming trade show and conference for the Asian gaming industry. Organized by the American Gaming Association and RX, G2E Asia made its debut in 2007, defining itself as the preeminent show for the Asian gaming–entertainment industry.
About the American Gaming Association (AGA)
As the national trade group representing the U.S. casino industry, the American Gaming Association (AGA) fosters a policy and business environment where legal, regulated gaming thrives. The AGA’s diverse membership of commercial and tribal casino operators, sports betting and iGaming companies, gaming suppliers, and more lead the $261 billion industry and support 1.8 million jobs across the country.
About RX (Reed Exhibitions)
RX is in the business of building businesses for individuals, communities, and organizations. We elevate the power of face-to-face events by combining data and digital products to help customers learn about markets, source products and complete transactions at over 400 events in 22 countries across 43 industry sectors. RX is passionate about making a positive impact on society and is fully committed to creating an inclusive work environment for all our people. RX is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. www.rxglobal.com
Laos Among CNN’s Top Picks for Asian Street Food

Two delectable dishes from Laos have made CNN’s list of the 50 best street foods in Asia.
Brunei to Play International Friendly Football Matches against Laos and Maldives
The Football Association of Brunei Darussalam (FABD) announced this week that the country will host a series of international friendly matches to re-establish football activities after a hiatus caused by the pandemic.
AAX Recognized by CoinGecko and CryptoCompare
CoinGecko ranked AAX as one of the top 20 and most trusted cryptocurrency exchanges.
VICTORIA, SEYCHELLES – Media OutReach – 24 August 2022 – AAX, a digital asset exchange for everyone, announced today that it has been recognized by CryptoCompare, an FCA authorized and regulated global leader in digital asset data, for its increase in spot trading volume in July 2022. CoinGecko, a leading data aggregation platform for the crypto market, has also ranked AAX as one of the most trusted cryptocurrency trading platforms.
CryptoCompare Exchange Review
According to CryptoCompare’s latest Exchange Review published in July 2022, AAX has been ranked the second-largest exchange by spot trading volume, with a rise of 285% in 2022. In July 2022, the digital asset exchange recorded US$57.2 billion in volume, a 26.5% rise from June, despite the decline of spot trading volumes across all centralized crypto exchanges.
CoinGecko Ranks Top Cryptocurrency Exchanges
CoinGecko has awarded AAX a Trust Score of 8, which indicates an increase. The new score indicates that AAX is now ranked as a 3-star Certified Ethereum Professional (CEP) Exchange.
Among the ranking criteria, AAX scored favorably in terms of liquidity, scale, cybersecurity, API coverage, and the availability of a senior leadership team. AAX was also recognized as a digital asset exchange that has not yet experienced security/functional issues that can potentially affect a user’s fund safety.
AAX’s Bug Bounty Program on HackenProof
AAX’s improved Trust Score follows the launch of its recent bug bounty program on HackenProof. The bug bounty program opens the door to the community and aims to shape a security-first platform with four top priorities – AAX’s website, its API, Android and iOS apps. The program offers payouts of up to $1,500 per critical vulnerability discovered, with smaller rewards for less critical bugs.
“Trust has alway been one of AAX’s core principles, along with security, integrity, and performance,” said Ben Caselin, VP of Global Marketing and Head of Research & Strategy at AAX. “Fully delivering on these principles takes time and constant improvement. It is great to see our achievements reflected in CoinGecko’s ranking as we continue to enhance our technological capability and services for our users..”
CoinGecko Guides Investors to the Best Exchanges with Its Trust Score
CoinGecko rolled out its Trust Score algorithm in 2019 to provide its users with transparent data so that they can make informed decisions on which platform they should entrust with their funds. In addition to liquidity, the CoinGecko Trust Score ranks exchanges based on trading activity, scale, technical expertise, cybersecurity, and other metrics.
For traders, it is of utmost importance to choose a trusted exchange. The crypto industry has been hit with multiple hacks on exchanges and DeFi protocols in recent months. One recent report by Atlas VPN found that hackers stole over $672 million through various heists and scams in the first three months of 2022 alone. Moreover, hacks on unregulated crypto exchanges and DeFi platforms have become common, resulting in millions of dollars of investors’ funds lost.
Hashtag: #AAX
About AAX
AAX is a top-tier digital assets exchange that caters to a global audience, with a vision of bringing the benefits of digital assets to everyone. Through an accessible range of products and by contributing to the conversation about digital assets and culture, we aim to empower the estimated 96% of people worldwide who do not yet own Bitcoin and other digital assets to build better and more inclusive economies.
Favored by more than three million users in over 160 countries, AAX is the first exchange to use the Satoshi Standard (SATS) to drive the adoption of Bitcoin. We are also the first to be powered by LSEG Technology, offering high-yield savings packages, 200+ spot pairs, deeply liquid futures markets, regular discounts on major tokens and a range of on- and off-ramp products.
Welcome to visit AAX official website for more information: https://www.aax.com/
For the latest news, you can follow AAX social media platforms to learn more:
https://t.me/aaxcommunity
https://twitter.com/AAXExchange
https://www.instagram.com/aaxexchange/
https://www.facebook.com/AAXExchange
https://discord.com/invite/nMJf6QnPAa
https://www.youtube.com/c/AAXExchange
https://www.linkedin.com/company/aaxexchange/
MODIFI’s H2 2022 Predictions Report assesses current, forthcoming factors affecting global supply chains
The report explores the current state of the logistics industry and its impact on global trade and the supply chain
BERLIN, GERMANY – Media OutReach – 24 August 2022 – Global Fintech MODIFI, today released its Global Supply Chain Disruptions: H2 2022 Prediction Report .In this report, Industry experts from around the world weigh in on their predictions for how supply chains will change and businesses must adapt from the impacts caused by the COVID-19 pandemic and recent world events.
Expert viewpoints on the external factors disrupting and transforming the supply chain industry, including economic challenges caused by rising inflation, skyrocketing fuel prices, and international conflicts are explored. The report also highlights how the retail industry is affected by emerging technology that enables exporters and importers to match supply with demand patterns, and track modern purchasing habits and choices.
One of the biggest trends being seen is geographic dispersion of a buyer’s supplier base. “The crisis in Ukraine and Russia, as well as other supply chain disruptions, such as COVID-19 lockdowns, staffing shortages and labor unrest, have caused many businesses to look at more localized manufacturing and shorter supply chains. The accelerated transition is resulting in more companies increasing their investment in countries such as Vietnam, Thailand and India,” said Brian Dowd, Sales Director – North America.
To combat supply chain disruptions, our experts have also identified that technology is becoming critical to supply chain success in the U.S. as businesses invest in innovative tools to provide more insight into the movement of goods and inventory. Emerging technologies such as AI, predictive analysis, risk analysis and monitoring, are helping companies deal with disruptions and external obstacles by enabling leaders to make instant executive decisions within their supply chain.
And while many countries in the world, especially the U.S. and across Europe, are emerging from the COVID-19 crisis, the virus still casts a long shadow over China. As Chinese authorities implement strict pandemic restrictions in major cities and suspend operations at factories and businesses, this is affecting manufacturing and supply chains around the world. The report acknowledges that the global supply chain remains stretched, but predicts that we are over the peak, although it remains to be seen how long it will take before domestic transport returns to normal.
Buyers and sellers are also also using global payments to manage liquidity and risk. “When dealing with supply chain disruptions, both sellers and buyers are often unable to match payment term expectations, and the waiting period for payment can go up to 90 days.” said Brian Dowd, Sales Director – North America. In addition, since “Container shipping prices have only fallen 16% and continue to decrease slightly, but not drastically, so businesses are trying to diversify their risk by using models that pass some of the costs to buyers.” said Ankit Goel, Senior Vice President – Global Accounts.
The global supply chain market is in a period of turmoil and organizations across the world are attempting to build resilience into their systems. This means shifting to local suppliers, scrutinizing suppliers, investing in or stockpiling inventory, and investing in supply chain security. Organizations in every country are using technology to transform the way they do business to secure opportunities in an uncertain future.
To learn more and access MODIFI’s Global Supply Chain Disruptions: H2 2022 Predictions Report, please download the report here.
Hashtag: #MODIFI
About MODIFI:
MODIFI enables global commerce through a platform for business payments and trade management software. With MODIFI, sellers get paid instantly, while their buyers have the option to pay later. Our customers are also able to access a wide range of services that protect them from risk, and help them track and manage their shipments, all in one platform.
MODIFI is backed by MAERSK, GFC, Picus Capital, Intesa San Paolo and Heliad. Serving thousands of exporters and importers across more than 40 countries, MODIFI is present across Germany, the Netherlands, the UK, the US, the UAE, India, Bangladesh, Pakistan, China, and Hong Kong.
For more information on MODIFI, visit www.modifi.com or follow us on
LinkedIn.