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A Robot Sat in the Driver’s Seat: THINKCAR and MUCAR Brought AI Diagnostics to 200+ KOLs at the AliExpress Brand+ Summer Party in London


LONDON, UK – Media OutReach Newswire – 15 June 2026 – At the AliExpress Brand+ Summer Party on Poland Street, a Unitree robot sat in the driver’s seat of a BYD ATTO 2 DM-i as a THINKCAR scanner ran a live vehicle scan beside it, while a second robot held a diagnostic tablet toward the crowd. Over 200 KOLs, car owners, and DIY enthusiasts watched AI-powered diagnostics in action.

The activation spanned two levels. Upstairs, THINKCAR demonstrated its professional lineup on the BYD — fault code parsing, AI-generated reports, and maintenance recommendations in under two minutes, with the robot visually connecting robotics, AI, and real-time diagnostics. Downstairs, MUCAR styled a basement alongside a classic BMW as a DIY garage, where enthusiasts explored accessible tools — highlighted by a live giveaway of MUCAR BT200 OBD scanners, with the team guiding winners through setup and fault diagnosis on the spot.

Video: https://youtube.com/shorts/wi6hXlqkF4A?feature=share

Predict the Champion, Win the Tool

The same AI diagnostic technology anchors the brands’ “Predict the Champion” giveaway. Visit mythinkcar.com/pages/predict-2026-champion to enter and view full rules. Prizes include THINKCAR and MUCAR diagnostic scanners. Closes June 30; winners announced during World Cup final week.

Why This Matters Now

Modern cars run on dozens of ECUs and thousands of data points per second. Traditional diagnostics waits for something to break; AI-assisted diagnostics reads data before the warning light turns on. The AI-powered diagnostics segment is among the fastest-growing in the automotive aftermarket, driven by wider EV adoption and software-defined vehicles — and tools once confined to dealer workshops are now portable and accessible to independent technicians, DIY drivers, and enthusiasts alike.

What’s Next

The London activation is one chapter of a broader campaign built around prediction, preparation, and the idea that every vehicle deserves a championship team. Upcoming phases include a real-vehicle AI diagnostics challenge and World Cup final fan engagement. The campaign runs through July.

Hashtag: #THINKCAR

The issuer is solely responsible for the content of this announcement.

About THINKCAR

THINKCAR is a global automotive technology company focused on professional diagnostics, intelligent repair solutions, ADAS calibration, and TPMS systems. Serving 215+ countries.

www.thinkcar.com | www.mythinkcar.com

About MUCAR
MUCAR provides smart, accessible vehicle diagnostic solutions combining user-friendly design with AI-powered technology.

www.mucarus.com

China-Indonesia Cross-Border QR Payment Linkage Fully Launched, Achieving Nationwide Coverage

SHANGHAI, CHINA – Media OutReach Newswire – 15 June 2026 – On June 11, the People’s Bank of China (PBOC) and Bank Indonesia held the Second Governors’ Meeting of the Joint Work Program in Shanghai, announcing a series of financial cooperation outcomes. The China-Indonesia cross-border QR payment linkage was officially launched in the presence of the governors of both central banks. With this milestone, the number of UnionPay QR merchants outside the Chinese mainland has surpassed 46 million. In attendance at the ceremony were Dong Junfeng, Chairman of China UnionPay and UnionPay International (UPI); Santoso Liem, Chairman of the Indonesian Payment System Association (ASPI); Ge Haijiao, Chairman of Bank of China; Larry Wang, CEO of UPI; and Yang Peng, CEO of Ant International.

Under the government-to-government (G2G) framework, guided by both central banks, and with participation from multiple industry stakeholders, the payment linkage has become a benchmark for digital finance cooperation between China and Indonesia, creating profound impact in the following ways.

First, the linkage delivers convenient, secure, and efficient cross-border payment services to the people of both countries, facilitating bilateral people-to-business exchanges and promoting trade relations.

Second, UnionPay has fully leveraged its role as the hub of the payment industry, collaborating with Ant International and Bank of China (Hong Kong) Jakarta Branch to set a prime example of Chinese enterprises working in concert for global expansion.

Third, the project pioneers bilateral local currency settlement, whereby transactions made by Indonesian wallets in the Chinese mainland are settled in RMB, and transactions made by Chinese wallets in Indonesia are settled in Indonesian Rupiah—effectively enhancing the acceptance and user stickiness of the RMB in international markets.

Fourth, the initiative creates a replicable, scalable framework for cross-border payment connectivity, paving the way for an expansion into more regions across the globe, such as Latin America and Europe.

With the full rollout, two-way cross-border QR code payments have achieved near-nationwide coverage. So far, payment networks in seven out of the eleven ASEAN nations are interoperable with UnionPay.

Chinese users can now use the UnionPay App, banking apps integrated with the UnionPay MobileWallet Connect, and Alipay to make QR payments at tens of millions of QRIS (Quick Response Code Indonesian Standard) merchant locations across Indonesia. Likewise, visitors from Indonesia can pay to UnionPay and Alipay QR merchants in the Chinese mainland with dozens of major Indonesian wallets, such as MyBCA, OVO, DANA, GoPay, Mandiri and ShopeePay.

In recent years, UnionPay continues to grow its global card and QR payment networks and enhance its cross-border payment ecosystem. To date, UnionPay has launched over 200 UnionPay-powered wallets in 37 countries and regions outside the Chinese mainland. Since the beginning of 2026, transactions made by these wallets in China have doubled year-on-year in both transaction count and value, while the number of QR payments made outside the mainland by the UnionPay App and Chinese partner wallets has surged over 300% year-on-year. Moving forward, UnionPay will remain committed to its strategic vision of “Trusted Ties, Shared Success”, scale up two-way payment linkages, enhance user experiences, and deliver more benefits to consumers worldwide.

Hashtag: #UnionPay

The issuer is solely responsible for the content of this announcement.

From Trade Gateways To Community Lifelines: Batangas Port Is The World’s First ‘Ready Port’ For Disaster Preparedness

This recognition establishes a new global benchmark for disaster preparedness and humanitarian logistics, creating a scalable model for vulnerable coastal regions worldwide.


BATANGAS CITY, PHILIPPINES – Media OutReach Newswire – 15 June 2026 – Global trade enabler DP World today announced that its Batangas Integrated Port (BIP) is now the world’s first READY Port, establishing a new benchmark for disaster preparedness and humanitarian logistics.

Batangas Integrated Port is now the world's first READY Port
Batangas Integrated Port is now the world’s first READY Port

READY Port (Resilience, Emergency Action, and Disaster-ready) is a global capacity-strengthening programme advocated by the UN Logistics Cluster, established to strengthen disaster readiness of ports to enable humanitarian resiliency of countries during emergencies.

As climate-related disasters and supply chain disruptions increase globally, the READY Port framework offers a scalable model for enhancing the resilience of critical logistics infrastructure. The Philippines was selected as the pilot location for the initiative due to its exposure to climate-related risks and natural disasters. Bringing together key public and private sector stakeholders, as well as local and international humanitarian organisations, READY Port establishes a coordinated and resilient emergency response ecosystem anchored on seaports and logistics hubs.

The designation follows the completion of a three-day, multi-stakeholder READY Port workshop in partnership with the World Food Programme (WFP) Philippines at Batangas Port, where government agencies, humanitarian organisations and private-sector partners assessed emergency response capabilities, reviewed operational protocols and participated in scenario-based exercises to strengthen crisis preparedness.

BIP is operated by DP World’s local partner, Asian Terminals Inc. (ATI) and serves as a critical gateway for the Philippines, offering comprehensive capabilities for international and domestic cargoes, rolling cargoes, passenger movements, and direct connectivity to nearby islands and key destinations across the Visayas and Mindanao.

Insights from the workshop have been consolidated into a Port Readiness Action Plan to help strengthen strategic frameworks for future implementation of capacity-building initiatives across ports in the Philippines and around the world.

Glen Hilton, CEO & Managing Director, Asia Pacific, DP World, said: “We are honoured that the Batangas Integrated Port is now the world’s first READY port. This collaboration with WFP and our partners reflects our shared commitment to building resilient port infrastructure that serves not only as gateways for trade, but also as vital lifelines for communities during times of crisis. By leveraging DP World’s integrated ports and logistics capabilities through ATI, our local partner in the Philippines, and across our global network, we are strengthening preparedness and ensuring that humanitarian assistance can move swiftly and efficiently in support of disaster response, national recovery efforts, and community resilience.”

Manuel Cabochan III, Department of Transportation Assistant Secretary for Special Concerns, said: “Disaster preparedness is not only the responsibility of one government agency alone. It requires a whole-of-government and whole-of-society approach where national agencies, port operators, logistics providers, humanitarian organizations, local government units, and development partners work together towards a common goal. This underscores the importance of READY Port as we come together to prepare through planning, capacity building, and information sharing, and ultimately develop strong mechanisms to ensure continuity of ports and logistics operations during emergencies. We commend the World Food Programme, DP World, and the Logistics Cluster for pioneering this initiative.”

Joao Dos Santos Merencio, World Food Programme Head of Supply Chain in the Philippines, said: “WFP is committed to supporting this initiative by fostering coordination, sharing humanitarian experience, and working closely with all stakeholders to align port readiness efforts with national disaster preparedness frameworks. The READY Port initiative brings together port authorities, national government agencies, the private sector, and the humanitarian community as one cohesive support unit. This framework helps ensure that ports continue to operate effectively under crisis conditions while prioritizing humanitarian cargoes when it matters most.”
Hashtag: #DPWORLD



The issuer is solely responsible for the content of this announcement.

About DP World

DP World is reshaping the future of global trade to improve lives everywhere. Operating across six continents with a team of over 125,000 employees, we combine global infrastructure and local expertise to deliver seamless supply chain solutions. From Ports and Terminals to Marine Services, Logistics and Technology, we leverage innovation to create better ways to trade, minimizing disruptions from the factory floor to the customer’s door.

In Asia Pacific, DP World employs over 11,000 people across 22 geographies. We operate 17 ports and terminals, complemented by a comprehensive suite of end-to-end supply chain solutions – to connect the region to the rest of the world.

WE MAKE TRADE FLOW

ACE ROBOTICS’ Kairos World Model Leads Multiple Global Embodied-Intelligence Benchmarks


SHANGHAI, CHINA – Media OutReach Newswire – 15 June 2026 – ACE ROBOTICS today announced that its open-source Kairos world model has achieved leading results across four global embodied-intelligence benchmarks: RoboTwin 2.0, LIBERO-Plus, WorldModelBench Robot and DreamGen. Kairos ranked first among evaluated world models and vision-language-action (VLA) systems on these benchmarks’ public leaderboards as of 12 June 2026, leading across the core capabilities of embodied intelligence, including complex robotic manipulation, scene-level generalization, physical-world modeling and zero-shot transfer. The project is openly available on GitHub, Hugging Face and ModelScope, giving researchers and developers a public reference point for the model, benchmark results and technical materials.

Tops Four Leading Benchmarks in World Generation & Prediction
Tops Four Leading Benchmarks in World Generation & Prediction

Embodied intelligence faces a fundamental challenge: generalization. A robot must operate reliably in environments it has never seen, adapting to new lighting, layouts, objects, embodiments and noisy real-world conditions. While VLA models have become a prevailing approach by directly mapping perception and language inputs to robot actions, ACE ROBOTICS believes world models offer a more scalable path by explicitly learning the underlying dynamics of the physical world and predicting how environments evolve. Kairos is designed to validate that approach.

Leading scene-level generalization on LIBERO-Plus

One of Kairos’ most significant results comes from LIBERO-Plus, a scene-level generalization benchmark proposed by the Shanghai Innovation Institute with Fudan University, Tongji University and the National University of Singapore. It evaluates robustness under seven real-world variables: camera angle, robot embodiment, language instruction, lighting, background, sensor noise and spatial layout.

Kairos achieved an overall score of 89.0, ranking first among all evaluated world models and VLA systems. It surpassed leading VLA models including ACoT-VLA (88.0), Pi 0.5 (85.7) and ProGAL-VLA (85.5), as well as the Being-H0.7 world model (84.8). It also showed strong environmental robustness, with near-ceiling performance on lighting (97.7), noise (96.8) and background (95.8), and ranked highly on camera angle and language instruction.

According to ACE ROBOTICS, this marks the first time a world-model approach has outperformed leading VLA systems on LIBERO-Plus for scene-level generalization, pointing to a path where robots adapt to homes, factories, retail spaces and other environments with far less environment-specific retraining.

A compact model with strong physical modeling efficiency

On WorldModelBench Robot, a physical-modeling benchmark proposed by researchers from UC Berkeley, UC San Diego, NVIDIA and MIT, Kairos-4B achieved an overall score of 9.30, ranking first on the benchmark. With only 4 billion parameters, it outperformed larger systems including 28-billion-parameter Lingbot, 16-billion-parameter Cosmos 3, 14-billion-parameter Abot-PhysWorld and 5-billion-parameter Wan 2.2, setting a new record for parameter efficiency in embodied world models.

Kairos matched the top instruction-following score (2.36) of the 16-billion-parameter Cosmos 3 with about one quarter of the parameters, a fourfold efficiency gain. It scored 4.96 on physics adherence, with perfect marks on Newtonian mechanics and gravity, and a perfect score on temporal quality, reflecting strong temporal consistency and visual continuity over long horizons.

A unified architecture, not a modular pipeline

ACE ROBOTICS attributes Kairos’ performance to its native unified “multi-modal understanding-generation-prediction” architecture. Unlike modular approaches that stitch together separate components for world understanding, generation and prediction, Kairos integrates these within a single backbone that shares one global world state, reducing the information loss and coordination latency between modules for more consistent physical modeling, stronger long-horizon prediction and more reliable action planning.

ACE ROBOTICS first introduced this architecture in December 2025, and the broader industry is now converging on a similar path: NVIDIA’s Cosmos 3.0, introduced in 2026, adopts a comparable single-system design that brings vision reasoning, world generation and action prediction into one architecture. Built on this foundation, Kairos-4B is, in ACE ROBOTICS’ description, the first embodied world model able to drive a physical robot directly on-device, closing the perception-to-action loop without intermediate translation latency.

Leading on synthetic data transfer and complex robot manipulation

Kairos also ranked first on DreamGen Bench, a benchmark led by NVIDIA with the University of Washington, UC Berkeley and UCLA that measures how well synthetic data generated by world models transfers to unseen objects, behaviors and environments, a key predictor of downstream robot-training value. Kairos ranked first on both average physics adherence (AVG_PA 0.538) and overall average score (AVG_Score 0.618), and led globally on new-behavior execution and new-environment adaptation.

On RoboTwin 2.0, a demanding dual-arm manipulation benchmark proposed by Shanghai Jiao Tong University and the University of Hong Kong with Shanghai AI Laboratory, Kairos scored 96.1% — a state-of-the-art result on the benchmark’s public leaderboard as of 12 June 2026. Across the benchmark’s 50 complex two-arm tasks it scored 96.9% in clean scenarios and 95.2% in randomized scenarios, ahead of VLA models such as G0.5 (93.2) and starVLA (88.3) and world models including AIM (93.1), Fast-WAM (91.8) and MotuBrain (96.0).

From benchmark leadership to commercial deployment

Together, these results validate Kairos’ technical direction across the core dimensions of embodied intelligence, from physical-rule understanding and zero-shot generalization to environmental robustness and fine-grained dual-arm manipulation, supporting ACE ROBOTICS’ aim to move robots beyond task imitation toward physical-world understanding, long-horizon reasoning and real-world execution.

The results come as ACE ROBOTICS accelerates commercialization. The company says it has raised several hundred million U.S. dollars across financing rounds in the first half of 2026, including a recent Angel+ round backed by investors such as Dachen Caizhi, Shenzhen Capital Group and the Shanghai Sci-Tech Innovation Fund, with existing shareholder SenseTime’s Guoxiang Capital increasing its stake. The proceeds will support continued world-model research and integrated hardware-software solutions for sectors including smart retail, security and inspection, tourism and hospitality.

“Embodied intelligence is the next era of AI, and a world model is the key to unlocking it,” said Wang Xiaogang, Chairman of ACE ROBOTICS. “Our mission is to give every robot a capable brain.”

Kairos is openly available on GitHub, Hugging Face and ModelScope:
https://github.com/kairos-agi/kairos-sensenova
https://huggingface.co/kairos-agi
https://modelscope.cn/collections/kairos-team/kairos30

Hashtag: #ACEROBOTICS


The issuer is solely responsible for the content of this announcement.

About ACE ROBOTICS – Equipping robots with intelligent “brains” and engaging “souls”

ACE ROBOTICS is a pioneering robotics company dedicated to advancing the field of embodied intelligence. Through breakthrough technological innovations and deep insights into embodied intelligence scenarios, we aim to empower robots with the ability to autonomously understand and explore the physical world, thereby accelerating their commercial implementation.

The company pioneered the ACE R&D paradigm and built a vision-based “environmental data engine, real-world cognition, embodied interaction generalization” technology chain. Using full spatiotemporal and multi-perspective environmental capture as its engine, along with Kairos 3.0 – China’s first open-source and commercially applicable world model – plus the Embodied Foundation Model as its technical backbone, ACE ROBOTICS addresses core industry challenges such as data scarcity, common sense gaps, poor generalization, and limited versatility. Simultaneously, the company unveiled its flagship A1 Embodied Super Brain Module, accelerating the large-scale commercial deployment of embodied intelligence across diverse scenarios.

ACE ROBOTICS is both a technology pioneer and an ecosystem builder. Through strategic cooperation with top hardware manufacturers, cloud service providers, and vertical scenario partners, we have broken through the “model-hardware-scenario” industrial deadlock, providing standardized and customized solutions that are driving the development of China’s embodied intelligence industry.

Monport Highlights Growing Demand for Personalized Father’s Day Gifts Powered by Advanced Laser Engraving Technology

New laser engraving solutions help makers and businesses create custom Father’s Day gifts with greater precision, speed and material versatility

NEW YORK, June 15, 2026 /PRNewswire/ — As consumers increasingly seek meaningful and personalized Father’s Day gifts, laser engraving technology is emerging as a powerful tool for transforming ordinary products into memorable keepsakes. From custom wooden signs and engraved tumblers to personalized tools and metal accessories, laser engraving continues to drive growth in the personalization market, enabling makers, entrepreneurs and small businesses to meet rising demand for unique gift experiences.

According to industry trends, personalized products continue to outperform traditional gift categories because they offer emotional value, customization and long-term sentimental appeal. Father’s Day remains one of the strongest seasonal opportunities for businesses specializing in customized products, with consumers actively searching for gifts that reflect personal stories, family memories and meaningful milestones.

To support creators and businesses during the Father’s Day season, Monport Laser is showcasing its latest lineup of laser engraving solutions, including the Monport MegaS 70W CO2 Laser Engraver & Cutter, Monport GM 10W UV Laser Engraver & Marking Machine, and Monport GA 60W MOPA Fiber Laser Integrated Engraver & Color Marking Machine with AutoFocus.

“Personalization has become one of the most influential trends in the gift industry,” said the Monport CEO. “Today’s consumers want gifts that feel thoughtful and unique. Advanced laser engraving technology allows businesses and creators to deliver high-quality customized products efficiently while expanding the range of materials and applications available for Father’s Day gifting.”

Personalized Gifts Continue to Drive Consumer Demand

The shift toward personalized gifting reflects broader consumer preferences for products that offer both utility and emotional significance. Popular Father’s Day gift categories increasingly include customized items such as:

  • Engraved wooden plaques
  • Personalized tool sets
  • Custom leather accessories
  • Engraved drinkware
  • Metal wallets and card holders
  • Family photo engravings
  • Personalized office décor
  • Custom keepsake boxes

Unlike mass-produced gifts, laser-engraved products can incorporate names, dates, messages, logos, photographs and artwork, creating one-of-a-kind items that resonate with recipients.

For businesses operating in the custom products market, laser engraving technology provides an efficient method for producing personalized items while maintaining consistency and professional-grade quality.

Monport MegaS Expands Opportunities for Custom Wood and Acrylic Gifts

Among the most popular Father’s Day gift materials are wood and acrylic, both of which offer versatility for home décor, keepsakes and personalized display pieces.

The Monport MegaS 70W CO2 Laser Engraver & Cutter is designed to help users create detailed engravings and precision cuts across a wide range of materials.

Featuring a maximum engraving speed of 600mm/s, a spacious 27.56-inch by 13.78-inch working area and engraving accuracy down to 0.03mm, the MegaS combines productivity and precision for both hobbyists and commercial users.

The system supports cutting materials up to 20mm acrylic and 18mm basswood, making it suitable for projects such as custom signs, engraved photo panels, decorative gifts and layered wood artwork. When paired with a telephoto focusing lens and external booster pump, cutting performance can improve by up to 25%.

Monport’s proprietary airflow design and integrated air assist system help reduce burn marks, preserve fine details, improve line clarity and deliver cleaner cutting results—important factors when producing premium personalized gifts.

Additional features such as auto focus, smart batch fill functionality and conveyor engraving compatibility allow businesses to streamline production during peak seasonal demand.

UV Laser Technology Unlocks New Personalization Applications

As consumers seek increasingly distinctive gifts, demand for engraving on delicate and specialty materials continues to grow.

The Monport GM 10W UV Laser Engraver & Marking Machine is engineered to engrave more than 1,500 material types, including glass, crystal, acrylic, ceramics, plastics and select metals.

Unlike traditional laser systems, UV laser technology produces highly detailed markings with minimal heat impact. The process generates virtually no smoke, eliminates material blackening and preserves surface quality, making it ideal for premium Father’s Day gifts such as engraved whiskey glasses, crystal keepsakes, custom awards and decorative collectibles.

The machine features an ultra-fine 0.0019mm laser spot size and engraving resolutions reaching up to 16K, enabling intricate photo engraving and high-detail artwork reproduction.

Monport also includes an intelligent water chiller system designed to maintain optimal laser operating temperatures across varying environmental conditions, helping ensure consistent performance and long-term reliability.

MOPA Fiber Laser Technology Expands Premium Metal Gift Personalization

Metal gifts remain one of the most popular Father’s Day categories, particularly among consumers seeking durable, high-end personalized products.

The Monport GA 60W MOPA Fiber Laser Integrated Engraver & Color Marking Machine with AutoFocus is designed to help businesses and makers create premium custom gifts through advanced color marking, deep engraving and precision cutting capabilities.

Featuring 60W laser power, one-click autofocus and engraving speeds of up to 10,000 mm/s, the system delivers fast and accurate results across a variety of metal applications. Its innovative 90-degree rotating laser head expands the engraving area up to 300mm x 300mm, providing greater flexibility for larger projects and specialty items.

The machine supports customization of products such as tumblers, medals, business cards, signage and keychains, while also enabling vivid color marking, 3D relief engraving and deep engraving on stainless steel, aluminum and brass.

With sub-micron precision and a compact integrated design, the GA 60W MOPA Fiber Laser helps businesses capitalize on the growing demand for personalized Father’s Day gifts and premium custom products..

Supporting Entrepreneurs in the Growing Personalization Economy

As e-commerce sellers, local businesses and custom product manufacturers continue expanding their personalization offerings, laser engraving technology has become an increasingly valuable production tool.

Modern laser systems allow businesses to:

  • Offer customized products at scale
  • Improve production efficiency
  • Expand material capabilities
  • Increase product value through personalization
  • Respond quickly to seasonal demand

For Father’s Day campaigns in particular, the ability to deliver personalized products with fast turnaround times can help businesses differentiate themselves in a competitive market.

About Monport Laser

Monport Laser is a provider of advanced laser engraving and cutting solutions for creators, entrepreneurs, manufacturers and businesses. Its product portfolio includes CO2 laser engravers, fiber laser engravers, UV laser engravers and industrial laser systems designed to support applications ranging from personalized gifts and custom products to manufacturing, marking and production workflows.

By combining precision engineering, intelligent automation and user-focused innovation, Monport continues to help businesses and makers unlock new opportunities in the growing personalization market.

Media Contact:
Monport Laser
Email: official@monportlaser.com
Website: www.monportlaser.com.

BHN encourages Aussies to send the spirit of soccer this FIFA World Cup 2026™ season

SYDNEY, June 15, 2026 /PRNewswire/ — As the world gears up for the kick-off of this year’s premier football tournament, global leader in branded payments, Blackhawk Network (BHN), is partnering with Visa, the official Worldwide Partner of the FIFA World Cup 2026™, to launch a limited-edition digital FIFA World Cup 2026™ Activ Visa™ Gift Card. Available from May 12 to July 19, the gift card can be purchased on Giftz.com.au and other participating digital distributors.

With a load range from $5-$1,000 and acceptance anywhere Visa is accepted, it’s a convenient and meaningful gift for football enthusiasts looking to be part of the action, on and off the pitch. Fans can choose between two bold designs and use the card to fully immerse themselves in FIFA World Cup 2026™.

For fans, the FIFA World Cup 2026™ Activ Visa™ Gift Card offers a flexible and exciting way to celebrate the tournament, bringing the spirit of the event into everyday moments. Whether it is gearing up with team jerseys, upgrading match-day viewing with snacks and entertainment, or securing memorabilia to remember iconic moments, the card empowers consumers to personalise their experience.

For businesses, the FIFA World Cup 2026™ Activ Visa™ Gift Card unlocks a high-impact opportunity to connect with customers, employees, and partners during one of the world’s most-watched events. Leveraging the tournament’s global appeal, businesses can tap into increased engagement and emotional resonance, incorporating FIFA World Cup 2026™-themed incentives into reward programs, promotional campaigns, and sales activations.

Blackhawk Network Head of ANZ Kieran said, “We are thrilled to collaborate with Visa to bring fans closer to the energy and excitement of the FIFA World Cup 2026™. These limited-edition gift cards are more than just a payment solution; they’re a way to encourage Australians to celebrate and engage with the passion of the tournament, whether rewarding someone, surprising a fan, or simply joining in the global buzz. It’s a timely, flexible and memorable way to give something that truly connects with the moment.”

Visa Head of Marketing for ANZ Meble Tin said, “As proud partners of FIFA World Cup 2026™, we are dedicated to enhancing the fans’ experience both in and out of the stadium. We see these FIFA Gift Cards as memorabilia, capturing a moment in time, reminding us of the joyful memories from this year’s FIFA World Cup.”

Concept Study Identifies Potential Refining Pathway at Shaakichiuwaanaan to Battery-Grade Lithium Carbonate

Study highlights potential to produce a value-added lithium chemical at site, offering further opportunities to reduce logistics intensity over time and aligning with Canada’s and Québec’s objectives for domestic processing of critical minerals 

MONTREAL, June 15, 2026 /PRNewswire/ — June 15, 2026 – Sydney, Australia 

Highlights

  • Concept study completed evaluating future potential to process spodumene concentrate into a value-added lithium product, directly at the Shaakichiuwaanaan site.
  • Following a structured review of seven processing flowsheet options to produce a “value added” lithium product, the study identified Primero’s (NRW Holdings (ASX: NWH) subsidiary “Primero”) proprietary ALi® atmospheric leach processas the preferred value-added pathway for further study, given:
    • its overall economic potential, strong logistics efficiency benefits and technical risk profile, and
    • its alignment with the Company’s sustainability objectives through practicing environmental care in processing and minimizing the Project’s environmental footprint.
  • Bench scale testwork on Shaakichiuwaanaan spodumene concentrate samples has been undertaken by Primero in Perth – Western Australia using the ALi® process, producing a 99.8% LiCO battery-grade lithium carbonate.
  • If combined with the use of electric calcination through Québec’s low-cost renewable energy, on-site value-added processing has future potential to reduce carbon intensity and improve efficiencies within the battery materials supply chain.
  • Supports the Québec and Canada’s objectives for domestic, value-added processing, consistent with their respective Critical Minerals Strategies.
  • The On-Site Refining Strategy is a staged, longer term, growth opportunity and is not required for the current proposed development of the base spodumene concentrate project outlined in the 2025 Feasibility Study.
  • Next steps – future work expected to determine how to capture further economic benefits of value-added products at site including potential introduction of electrical calcination technology to leverage the full potential of Québec’s renewable and low-cost hydroelectric power.

Frederic Mercier-Langevin, Chief Operations/Development Officer for the Company comments: “Shaakichiuwaanaan is already a Tier-1 asset under our 2025 Feasibility Study, and this concept study potentially identifies a credible pathway to capture additional value on top of it. Converting spodumene concentrate to a “value added” and potentially battery-grade lithium chemical on-site could deliver a lower-cost, lower-carbon flowsheet powered by Québec hydroelectricity.

“Bench scale results on Shaakichiuwaanaan concentrates indicate battery-grade purity is potentially achievable and the logistics savings could be material. Importantly, subject to further test work and demonstration at scale being undertaken, this could be a staged value-add opportunity for Shaakichiuwaanaan for future development beyond the base spodumene project. Further study work now underway will continue to test and determine the path forward,” added Mr. Mercier-Langevin. 

Ken Brinsden, President, CEO & Managing Director comments: “For decades the industry has mined hard-rock lithium in one place and refined it in another, often overseas, which is hardly the most efficient supply chain solution. The work we’re reporting today points to the potential for a redefinition of the supply chain. It could be a credible alternate pathway, demonstrated at bench scale with our spodumene concentrates, to refine battery-grade lithium at the mine gate in a stable Western, low-carbon supply chain. This is the kind of industry step-change, supported by Shaakichiuwaanaan’s premier geology, that drew me to this Project.”

PMET Resources Inc. (the “Company” or “PMET”) (TSX: PMET) (ASX: PMT) (OTCQX: PMETF) (FSE: R9GA) is pleased to report on initiatives to develop value-added lithium chemical products at its 100%-owned Shaakichiuwaanaan Project (the “Project”), located in the Eeyou Istchee James Bay region of Quebec, Canada.

The Project’s 2025 Feasibility Study base case has already demonstrated the resource scale and grade that contributes to the low-cost of a spodumene concentrate produced at Shaakichiuwaanaan.1 The Project also benefits from being adjacent to some of the lowest-cost renewable hydroelectric power in North America. With these strategic advantages as a backdrop, the Company is progressing the Project’s further assessment and development progress of its CV5 lithium-only project, with final mine authorization and extensive community consultation processes underway.

As part of its stated growth and diversification strategy to further add value to the Project, the Company has now completed a Concept Study assessing the potential to process spodumene concentrate into higher-value lithium chemical products directly at site. The work forms part of the Company’s broader long-term growth strategy to capture the potential additional value within the lithium supply chain while establishing a lower-carbon, Western-facing lithium chemicals platform in Québec. The Concept Study is based on low-level economic and technical assessments that are not sufficient to support the Company publishing production targets and economic outcomes or to provide assurance of an economic development case. The Concept Study does not constitute a preliminary economic assessment, pre-feasibility study, or feasibility study as defined under NI 43-101. Given the uncertainties involved, investors should not make any investment decision based solely on the results of the Concept Study.

A Potential redefinition of the North American Lithium Chemicals Supply

The Company believes the Shaakichiuwaanaan Project has the potential over its life to support an improved and more efficient lithium chemicals supply chain model, leveraging Québec’s abundant low-cost renewable hydroelectric power, strategic location within North America and proximity to key European and North American markets. Spodumene concentrate produced at Shaakichiuwaanaan is expected to be a raw material feed for a high-value chemical industry that is, to this day, largely conducted outside of Canada.

Producing a more concentrated, value-added lithia product on site is expected to provide the following benefits:

–  Redefine the lithium value chain model by locating electric calcination and some or all of the chemical conversion at the mine site, capturing significant logistical benefits by materially reducing shipped volumes and costs through the production of a concentrated higher lithia content product;

–  Leverage Québec’s renewable and low-cost hydroelectric power to support a lower-carbon lithium chemical supply chain, with the potential to enhance sustainability and materially reduce logistics-related emissions and fossil-fuel dependence;

–  Creation of a western-facing lithium chemical supply chain, supporting western mineral sovereignty and re-shoring value traditionally retained by downstream spodumene converters outside of Québec and Canada; and

–  Enhance Project value through the transformation of spodumene into a higher lithia content product that has the potential to command higher values and potentially broadening the Project’s customer-base.

Selecting the Process: Seven Options, One Preferred Pathway

The Company engaged Primero Group to complete a Concept Study to evaluate potential value-added processing routes for the spodumene concentrate produced at the Shaakichiuwaanaan Project. The primary objectives of the Study were to:

  • Reduce the logistics associated with transporting 5.5% Li2O Spodumene Concentrate (SC5.5) over long distances (844 km trucking to Matagami with subsequent 1,075 km rail route to shipping port);
  • Evaluate whether producing an industrial or battery grade lithium chemical could improve market flexibility and project value; and
  • Identify the most technically and economically robust processing route to progress into future study stages.

Phase 1 of the Study provided a concept level assessment of seven alternative flowsheets for chemical processing options, with the goal of narrowing down options to progress to a Phase 2 assessment, which focused on detailed refinement of product pathways. Within the Phase 2 assessment, both Acid Roast and Atmospheric Leach options were considered.

The Atmospheric Leach option (through Primero’s proprietary ALi® process) was found to deliver the strongest overall performance in the areas that most influence long-term Project value. At a conceptual level, it delivered the lowest comparable capital costs and operating costs, reagent and trucking burden, HSE and environmental risks and the shortest payback period with the highest overall potential financial return. Due to the preliminary nature of the Concept Study, Australian disclosure law prohibits the Company from presenting potential production and economic scenarios. Further detailed work is required before such information can be presented (see Next Steps – PEA Study below).  

ALi® Process Description

The ALi® flowsheet recovers lithium from beta spodumene through an atmospheric (low-pressure, lower-temperature) leach, stepping through ion exchange, before producing lithium carbonate by precipitation. Unlike the conventional high-temperature sulfuric acid roast that dominates hard-rock lithium refining, the atmospheric leach route is designed to operate with lower energy intensity, lower reagent consumption and resulting in a cleaner residue stream. Locating it at the mine gate keeps conversion close to the orebody and to the Project’s anticipated low-cost renewable power, regionalising a step in the supply chain that is conventionally performed offshore.

ALi® is one of a new generation of ‘acid-free’ lithium conversion flowsheets that replaces the conventional high-temperature sulfuric-acid roast (being the long-standing conventional industry route), with alkaline chemistry. The approach is designed to reduce reagent intensity and concentrated-acid handling, lower the process waste burden, while producing a more benign, potentially reusable residue.

In developing the ALi® process, Primero has processed several tonnes of 3rd party spodumene concentrate at its Pilot scale facility, producing several hundred kilograms of battery grade lithium carbonate. The same facilities have processed a smaller scale spodumene concentrate sample from Shaakichiuwaanaan to produce battery grade product, further supporting the proof of concept being applied by PMET to its downstream processing initiative.

The same acid-free approach (albeit leaching at high-pressure) is used at Tesla’s lithium refinery in Texas, the highest-profile commercial-scale example to date. Tesla refines spodumene at the chemical conversion facility in Texas, rather than shipping concentrate offshore for conversion. ALi® would apply that same principle at the Shaakichiuwaanaan mine gate, while targeting battery-grade lithium carbonate.

ALi® Process – Phase Two Testwork

As part of Phase 2 of the Concept Study, a bench-scale test program was conducted on approximately 10kg of an alpha spodumene lithium concentrate by ALS Metallurgy (Balcatta, Western Australia). The lithium concentrate used was generated from the dense media separation of material sourced from Shaakichiuwaanaan via the ApplePick program2

The concentrate was calcined (laboratory) at 1,050°C for 30 minutes, resulting in the conversion of 98.8% of the spodumene from the alpha to the beta phase. After milling, 2.2kg of the milled calcine was used for lithium extraction test work, utilizing Primero’s proprietary ALi® refining process (Figure 1 and Figure 2). The process resulted in a laboratory lithium extraction of 93.6%, based on beta spodumene lithium, with overall process recovery of 92.5%, inclusive of calcination.

Figure 1: Bench-scale testwork in progress at ALS Metallurgy (Balcatta, Western Australia).
Figure 1: Bench-scale testwork in progress at ALS Metallurgy (Balcatta, Western Australia).

 

Figure 2: Applepick concentrate sample, processed at ALS Balcatta in Western Australia.
Figure 2: Applepick concentrate sample, processed at ALS Balcatta in Western Australia.

A high-grade lithium carbonate product, prepared by crystallization of carbonate leach solutions was analysed by Intertek (Perth, Western Australia). The purity was found to be 99.8% Li2CO3, and all contaminants of concern were found to be well within 2023 Chinese standards for lithium carbonate3 tolerances, thereby potentially making the product suitable for battery grade carbonate.

Transport Logistics

By introducing the chemical conversion at the mine site, the Concept Study naturally identified the opportunity to significantly reduce transport and logistics costs, given the total tonnage of material to transport (both reagents and product) would be substantially reduced, leading to a natural reduction of the number of trucks on the road on a daily basis.

Further details pertaining to the overall value-added products assessment process and outcomes can be found in Appendix 1.

Next Steps – PEA Study

Based on the results outlined above, production of lithium carbonate using Primero’s ALi® Atmospheric Leach process was found to have the potential to deliver the most favorable overall Project outcome both from an economic and sustainability perspective. It combines strong relative economics compared to other options with lower operational complexity and the greatest improvement in logistics (both quantity and nature of material to be hauled over considerable distances).

The potential to generate a battery-grade product, commanding higher product value and improved marketability, represents meaningful upside that warrants advancing this flowsheet further. While the more conventional Acid Roast option remains a technically feasible alternative, its higher costs and risk profile and comparatively less beneficial logistics make it less attractive as the primary development path for operation at site.

The testwork completed to date has significantly advanced this potential value-add opportunity for the Shaakichiuwaanaan Project – which is already demonstrated as a Tier-1 lithium asset through the 2025 Feasibility Study – providing a compelling reason to continue with the initiative to unlock this additional upside. The next phase of work will therefore focus on advancing the Ali® process towards a PEA level of detail, inclusive of the following:

  • Additional testwork to support flowsheet design and environmental testwork for residue characterization;
  • Flowsheet development, including option to produce battery-grade lithium carbonate;
  • Detailed logistics study, with the intent of fully fleshing out synergistic opportunities between inbound reagents and outbound product transport;
  • Determination of residue management and disposal requirements, including investigation of potential to offset cement costs in underground mine pastefill based on pozzolanic properties of ALi® residue streams;
  • The inclusion of electric calcination equipment (kiln) is expected to harness Québec’s renewable, low-cost hydro-electric power, lowering operating costs and further reducing the Project’s carbon footprint – building on the initial emissions benefits delivered through reduced trucking and fossil-fuel dependence.

The next phase of work is expected to be completed over the next calendar year and will inform whether, when and how the value-added products opportunity could potentially be integrated into the broader Shaakichiuwaanaan development plan in the future. The initiative is being advanced as a staged value-add growth opportunity and is not required for the current proposed development of the base spodumene concentrate project contemplated in the 2025 Feasibility Study.

Provided this next stage of work continues to support the potential for the application of the ALi® process at Shaakichiuwaanaan, further development steps, such as the deployment of the process at pilot-scale, would likely be required.

Qualified/Competent Person

The technical and scientific information in this news release that relates to the Mineral Resource  Estimate, and exploration results for the Company’s properties is based on, and fairly represents, information compiled by Mr. Darren L. Smith, M.Sc., P.Geo., who is a Qualified Person as defined by National Instrument 43-101 – Standards of Disclosure for Mineral Projects (“NI 43-101”), and member in good standing with the Ordre des Géologues du Québec (Geologist Permit number 01968), and with the Association of Professional Engineers and Geoscientists of Alberta (member number 87868). Mr. Smith has reviewed and approved the related technical information in this news release.

Mr. Smith is an Executive and Vice President of Exploration for PMET Resources Inc. and holds common shares, Restricted Share Units (RSUs), Performance Share Units (PSUs), and options in the Company.

The information in this news release that relates to the Mineral Reserve Estimate and Feasibility Study and the bench-scale testwork results is based on, and fairly represents, information compiled by Mr. Frédéric Mercier-Langevin, Ing. M.Sc., who is a Qualified Person as defined by NI 43-101, and member in good standing with the Ordre des Ingénieurs du Québec. Mr. Mercier-Langevin has reviewed and approved the related technical information in this news release.

Mr. Mercier-Langevin is the Chief Operating and Development Officer for PMET Resources Inc. and holds common shares, RSUs, PSUs, and options in the Company.

About PMET Resources Inc.

PMET Resources Inc. is a pegmatite critical mineral exploration and development company focused on advancing its district-scale 100%-owned Shaakichiuwaanaan Property located in the Eeyou Istchee James Bay region of Quebec, Canada, which is accessible year-round by all-season road and proximal to regional hydro-power infrastructure.

In late 2025, the Company announced a positive lithium-only Feasibility Study on the CV5 Pegmatite for the Shaakichiuwaanaan Property and declared a maiden Mineral Reserve of 84.3 Mt at 1.26% Li2O (Probable)4. The study outlines the potential for a competitive and globally significant high-grade lithium project targeting up to ~800 ktpa spodumene concentrate using a simple Dense Media Separation (“DMS”) only process flowsheet. Further, the results highlight Shaakichiuwaanaan as a potential North American critical mineral powerhouse with significant opportunity for tantalum and caesium in addition to lithium.

The Project hosts a Consolidated Mineral Resource5 totaling 108.0 Mt at 1.40% Li2O and 166 ppm Ta2O5 (Indicated) and 33.4 Mt at 1.33% Li2O and 155 ppm Ta2O5 (Inferred), and ranks as a top ten lithium pegmatite globally in size. Additionally, the Project hosts the world’s largest pollucite-hosted caesium pegmatite Mineral Resource at the Rigel and Vega zones with 0.69 Mt at 4.40% Cs2O (Indicated), and 1.70 Mt at 2.40% Cs2O (Inferred).

For further information, please contact us at info@pmet.ca or by calling +1 (604) 279-8709, or visit www.pmet.ca. Please also refer to the Company’s continuous disclosure filings, available under its profile at www.sedarplus.ca and www.asx.com.au, for available exploration data.

This news release has been approved by

KEN BRINSDEN”                                                         

Kenneth Brinsden, President, CEO, & Managing Director

Disclaimer for Forward-Looking Information

This news release contains “forward-looking statements” and “forward-looking information” within the meaning of applicable securities laws.

All statements, other than statements of present or historical facts, are forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and assumptions and accordingly, actual results could differ materially from those expressed or implied in such statements. You are hence cautioned not to place undue reliance on forward-looking statements. Forward-looking statements are typically identified by words such as “plan”, “development”, “growth”, “continued”, “intentions”, “expectations”, “emerging”, “evolving”, “strategy”, “opportunities”, “anticipated”, “trends”, “potential”, “outlook”, “ability”, “additional”, “on track”, “prospects”, “viability”, “estimated”, “reaches”, “enhancing”, “strengthen”, “target”, “believes”, “next steps” or variations of such words and phrases or statements that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. 

Forward-looking statements include, but are not limited to, statements concerning the potential to process spodumene concentrate into higher-value lithium chemical products directly at site, including expected recoveries and product quality, the potential for transport and other logistics cost reductions where spodumene concentrate is processed directly at site, the preparation and release of a preliminary economic assessment (PEA) with respect to the processing of spodumene concentrate at site within the next calendar year, the matters that such PEA will consider and the timing thereof, the Company’s long-term growth strategy to capture additional value within the lithium supply chain while establishing a lower-carbon, Western-facing lithium chemicals platform in Québec, the selection, advancement and potential commercial application of ALi®’s process principles at the Shaakichiuwaanaan Property, the potential Project outcome both from an economic and sustainability perspective by producing lithium carbonate using Primero’s ALi® Atmospheric Leach process, the potential to generate a battery-grade product at scale with enhanced marketability and value, the potential of on-site value-added processing to reduce carbon intensity and improve efficiencies within the battery materials supply chain, the Company’s plans to advance further technical studies, testwork, pilot-scale activities and engineering work, the potential integration of value-added processing into the Project’s development plan, obtaining the required authorizations, approvals and permits for processing facilities, the preliminary nature of the Concept Study and its ability to support further technical and economic evaluation , and the preparation and release of an updated Feasibility Study in the second half of 2026.

Forward-looking statements are based upon certain assumptions and other important factors that, if untrue, could cause actual results to be materially different from future results expressed or implied by such statements. There can be no assurance that forward-looking statements will prove to be accurate. Key assumptions upon which the Company’s forward-looking information is based include, without limitation, the ability of the Company to leverage Québec’s renewable and low-cost hydroelectric power and other required infrastructure, the ability of the Company to successfully develop, scale, operate and implement ALi® and its Atmospheric Leach option at the Shaakichiuwaanaan Property and the technical, economic and commercial viability of such process, that the results of the Concept Study and other testwork may be indicative of potential future performance, the Company’s ability to achieve battery-grade carbonate, the ability to achieve anticipated reduction in transportation costs, the accuracy of reserve and resource estimates, the classification of resources and the assumptions on which the reserve and resource estimates are based, long-term demand and pricing for lithium (spodumene), tantalum (tantalite), and caesium (pollucite) supply, that exploration and development results continue to support management’s current plans for the Shaakichiuwaanaan Property development, the availability and cost of reagents, consumables and equipment, the Company’s ability to obtain required authorizations, approvals and permits for value-added processing, that the Concept Study results, which are preliminary in nature and not based on a PEA or feasibility study, will support further advancement of the project and the ability of the Company to complete the proposed PEA.

Forward-looking statements are also subject to risks and uncertainties facing the Company’s business, any of which could have a material adverse effect on the Company’s business, financial condition, results of operations and growth prospects. Readers should review the detailed risk discussion in the Company’s most recent Annual Information Form filed on SEDAR+, for a fuller understanding of the risks and uncertainties that affect the Company’s business and operations.

Although the Company believes its expectations are based upon reasonable assumptions and has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events or results not to be as anticipated, estimated or intended. There can be no assurance that forward-looking information will prove to be accurate. If any of the risks or uncertainties mentioned above, which are not exhaustive, materialize, actual results may vary materially from those anticipated in the forward-looking statements.

The forward-looking statements contained herein are made only as of the date hereof. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent required by applicable law. The Company qualifies all of its forward-looking statements by these cautionary statements.

Competent Person Statement (ASX Listing Rules)

The information in this news release that relates to the Feasibility Study (“FS”) for the Shaakichiuwaanaan Project, which was first reported by the Company in a market announcement titled “PMET Resources Delivers Positive CV5 Lithium-Only Feasibility Study for its Large-Scale Shaakichiuwaanaan Project” dated October 20, 2025 (Montreal time) is available on the Company’s website at www.pmet.ca, on SEDAR+ at www.sedarplus.ca and on the ASX website at www.asx.com.au. The production target from the Feasibility Study referred to in this news release was reported by the Company in accordance with ASX Listing Rule 5.16 on the date of the original announcement. The Company confirms that, as of the date of this news release, all material assumptions and technical parameters underpinning the production target in the original announcement continue to apply and have not materially changed.

The Mineral Resource and Mineral Reserve Estimates in this release were first reported by the Company in accordance with ASX Listing Rules 5.8 and 5.9 in market announcements titled “World’s Largest Pollucite-Hosted Caesium Pegmatite Deposit” dated July 20, 2025 (Montreal time) and “PMET Resources Delivers Positive CV5 Lithium-Only Feasibility Study for its Large-Scale Shaakichiuwaanaan Project” dated October 20, 2025 (Montreal time) and are available on the Company’s website at www.pmet.ca, on SEDAR+ at www.sedarplus.ca and on the ASX website at www.asx.com.au. The Company confirms that, as of the date of this news release, it is not aware of any new information or data verified by the competent person that materially affects the information included in the relevant announcement and that all material assumptions and technical parameters underpinning the estimates in the relevant announcement continue to apply and have not materially changed. The Company confirms that, as at the date of this announcement, the form and context in which the competent person’s findings are presented have not been materially modified from the original market announcement.

Appendix 1 – JORC Code 2012 Table 1 (ASX Listing Rule 5.8.2)

Section 1 – Sampling Techniques and Data

Criteria

JORC Code explanation

Commentary

Sampling techniques

 

  •  Nature and quality of sampling (eg cut channels, random chips, or specific specialized industry standard measurement tools appropriate to the minerals under investigation, such as down hole gamma sondes, or handheld XRF instruments, etc). These examples should not be taken as limiting the broad meaning of sampling.
  •  Include reference to measures taken to ensure sample representivity and the appropriate calibration of any measurement tools or systems used.
  •  Aspects of the determination of mineralization that are Material to the Public Report.
  •  In cases where ‘industry standard’ work has been done this would be relatively simple (eg ‘reverse circulation drilling was used to obtain 1 m samples from which 3 kg was pulverized to produce a 30 g charge for fire assay’). In other cases more explanation may be required, such as where there is coarse gold that has inherent sampling problems. Unusual commodities or mineralization types (eg submarine nodules) may warrant disclosure of detailed information.

 

  •  Feed samples to the DMS processing were comprised of angular spodumene pegmatite boulders interpreted to be sourced from the CV5 Pegmatite.
  •  The boulders were located immediately down-ice to the southwest of the principal outcrop of the CV5 Pegmatite and were of similar size, situated in close proximity to each other, and exposed at surface.
  •  Based on location, size, angularity, and mineralogy of the boulders, as well as an understanding of glacial movement in the region, the source is interpreted with high confidence to be the CV5 Pegmatite, and most likely the principal outcrop.
  •  Therefore, although not in-situ samples, based on location, size, angularity, and mineralogy, the boulders are considered reasonably representative of the CV5 Pegmatite body as it is – with high confidence – their interpreted source.
  •  Boulders were selected based on estimated spodumene percentage as the primary objective was to maximize the amount of spodumene concentrate produced.

Drilling techniques

  •  Drill type (eg core, reverse circulation, open-hole hammer, rotary air blast, auger, Bangka, sonic, etc) and details (eg core diameter, triple or standard tube, depth of diamond tails, face-sampling bit or other type, whether core is oriented and if so, by what method, etc).

 

  •  N/A. No drill results reported.

 

Drill sample recovery

  •  Method of recording and assessing core and chip sample recoveries and results assessed.
  •  Measures taken to maximize sample recovery and ensure representative nature of the samples.
  •  Whether a relationship exists between sample recovery and grade and whether sample bias may have occurred due to preferential loss/gain of fine/coarse material.

 

  •  N/A. No drill results reported.

 

Logging

  •  Whether core and chip samples have been geologically and geotechnically logged to a level of detail to support appropriate Mineral Resource estimation, mining studies and metallurgical studies.
  •  Whether logging is qualitative or quantitative in nature. Core (or costean, channel, etc) photography.
  •  The total length and percentage of the relevant intersections logged.

 

  •  N/A. No drill results reported.

 

Sub-sampling techniques and sample preparation

  •  If core, whether cut or sawn and whether quarter, half or all core taken.
  •  If non-core, whether riffled, tube sampled, rotary split, etc and whether sampled wet or dry.
  •  For all sample types, the nature, quality and appropriateness of the sample preparation technique.
  •  Quality control procedures adopted for all sub-sampling stages to maximize representivity of samples.
  •  Measures taken to ensure that the sampling is representative of the in situ material collected, including for instance results for field duplicate/second-half sampling.
  •  Whether sample sizes are appropriate to the grain size of the material being sampled.

 

  •  The boulders were crushed at site, using a mechanical crusher, to approximately 10 cm and composited into bulk bags for transport. At the laboratory (SGS Lakefield, ON), the received samples were further crushed and screened to -9.5 mm/+0.8 mm to be used as feed to the DMS circuit.
  • Downstream Processing
  •  The following metallurgical testwork has been undertaken on DMS concentrate and subsequent process liquors and products:
    • Calcination
    • Leaching
    • Ion exchange
    • Precipitation
  •  The DMS concentrate was oven-dried at 105°C for 12 hours to remove free moisture prior to stage-crushing to 100% passing 3 mm in preparation for head assay analysis (chemical and mineralogy) and calcination. After blending, a representative subsample of the -3 mm material was collected for the head chemical analysis.
  •  The X-ray diffraction (XRD) analysis on the as-received DMS concentrate and LRC residue was performed by McKnight Mineralogy using a Panalytical Aeris Research Powder Diffractometer to obtain XRD traces on the samples. Operating conditions were 40kV/15mA, Fe Kß filter, step scan 0.01/29 secs˚2Ɵ at, 1/4˚ divergence and a 1.0˚ ant-scatter slit. Scan range was 5° to 90° 2Ɵ using a PixCel linear detector. Phases were identified by computer search-match of the 2025 ICSD, ICDD and COD Databases. Quantitative results have been determined with full pattern Rietveld refinement software.
  •  The chemical head assay of the DMS concentrate was performed by the ALS inhouse analytical laboratory using the following analytical methods:
  • o Sodium Peroxide (Na2O2) fusion – followed by ICP for the analysis of Lithium, Arsenic, Caesium, Rubidium.
  • o Lithium Metaborate (LiBO2) fusion – finish with XRF for the analysis of Aluminium, Calcium, Iron, Potassium, Magnesium, Sodium, Phosphorus and Silicon.
  •  A representative subsample of the calcined spodumene was taken for chemical assay and hot acid solubility Digest for α to β Conversion analysis.
  •  A representative subsample of the leached slurry was taken for analysis to determine the atmospheric leaching performance.
  •  At the conclusion of the precipitation test, a final liquor subsample was taken for chemical assay. The washed Lithium Carbonate was oven dried at 105°C to until the mass remained constant and submitted to the Intertek laboratory for low detection limit chemical analysis.

 

Quality of assay data and laboratory tests

  •  The nature, quality and appropriateness of the assaying and laboratory procedures used and whether the technique is considered partial or total.
  •  For geophysical tools, spectrometers, handheld XRF instruments, etc, the parameters used in determining the analysis including instrument make and model, reading times, calibrations factors applied and their derivation, etc.
  •  Nature of quality control procedures adopted (eg standards, blanks, duplicates, external laboratory checks) and whether acceptable levels of accuracy (ie lack of bias) and precision have been established.

 

  •  DMS concentrate underwent a standard analytical preparation procedure at SGS Canada’s Lakefield facility. Samples were then assayed by lithium borate fusion XRF for whole rock / oxides (code GC_XRF72MET), aqua regia ICP-MS (code GC_IMS91AC2) for multi-element, and four-acid ICP-OES for multi-element (code GC_ICP92A50).
  •  The Company has relied on the laboratory’s internal QAQC.
  •  Testwork methods are considered appropriate for the level of evaluation and results targeted.
  • Downstream Processing
  •  The following metallurgical testwork has been undertaken on DMS concentrate and subsequent process liquors and products:
    • Calcination
    • Leaching
    • Ion exchange
    • Precipitation
  •  All solid samples are thoroughly washed with water and dried
  •  Final samples are homogenised and riffled to provide a representative sub sample.
  •  Assay sub samples are reconciled to head assays to confirm accuracy of results.
  •  Samples have been analysed by external laboratories utilising industry standard methods.
  •  Testwork methods are considered appropriate for the level of evaluation and results targeted.
  •  Standard industry practices for QA/QC applied to all sample preparation and metallurgical assays.

 

Verification of sampling and assaying

  •  The verification of significant intersections by either independent or alternative company personnel.
  •  The use of twinned holes.
  •  Documentation of primary data, data entry procedures, data verification, data storage (physical and electronic) protocols.
  •  Discuss any adjustment to assay data.

 

  •  N/A. No drill results reported.
  •  Adjustments to data include reporting lithium, and tantalum in their oxide forms, as it is reported in elemental form in the assay certificates. Formulas used are Li2O = Li x 2.153.

 

Location of data points

  •  Accuracy and quality of surveys used to locate drill holes (collar and down-hole surveys), trenches, mine workings and other locations used in Mineral Resource estimation.
  •  Specification of the grid system used.
  •  Quality and adequacy of topographic control.

 

  •  Boulders were collected from a field located at approximately 570039 E, 5930560 N as determined by handheld GPS.
  •  The coordinate system used is UTM NAD83 Zone 18.
  •  The Company completed a property-wide LiDAR and orthophoto survey in August 2022, which provides high-quality topographic control.
  •  The quality and accuracy of the topographic controls are considered adequate for advanced stage exploration and development, including Mineral Resource estimation.

 

Data spacing and distribution

  •  Data spacing for reporting of Exploration Results.
  •  Whether the data spacing and distribution is sufficient to establish the degree of geological and grade continuity appropriate for the Mineral Resource and Ore Reserve estimation procedure(s) and classifications applied.
  •  Whether sample compositing has been applied.

 

  •  Feed samples to the DMS processing were comprised of angular spodumene pegmatite boulders collected from the same boulder field immediately down-ice to the southwest of the principal outcrop of the CV5 Pegmatite. The source of these boulders is interpreted with high confidence to be the CV5 Pegmatite, and most likely the principal outcrop.
  •  As the boulders are by definition not in-situ, the data derived from them is not sufficient to inform a Mineral Resource Estimate.
  •  Several boulders were composited into a single sample for the DMS pilot run.

 

Orientation of data in relation to geological structure

  •  Whether the orientation of sampling achieves unbiased sampling of possible structures and the extent to which this is known, considering the deposit type.
  • If the relationship between the drilling orientation and the orientation of key mineralized structures is considered to have introduced a sampling bias, this should be assessed and reported if material.
  • N/A. No drill results reported.

 

  •  N/A. No drill results reported.

 

Sample security

  •  The measures taken to ensure sample security.

 

  •  The sample for testwork remained under the custody of SGS Canada Inc. as they also completed the testwork and geochemical analysis.

 

Audits or reviews

  •  The results of any audits or reviews of sampling techniques and data.

 

  • A review of the sample procedures for the Company’s drill programs has been reviewed by several Qualified/Competent Persons through multiple NI 43-101 technical reports completed for the Company and deemed adequate and acceptable to industry best practices. The most recent Technical Report includes a review of sampling techniques and data through 2024 (drill hole CV24-787) in a technical report titled “CV5 Pegmatite Lithium-Only Feasibility Study NI 43-101 Technical Report, Shaakichiuwaanaan Project” with an Effective Date of October 20, 2025, and Issue Date of November 14, 2025.
  •  Additionally, the Company continually reviews and evaluates its procedures in order to optimize and ensure compliance at all levels of sample data collection and handling.

 

Section 2 – Reporting of Exploration Results

Criteria

JORC Code explanation

Commentary

Mineral tenement and land tenure status

  •  Type, reference name/number, location and ownership including agreements or material issues with third parties such as joint ventures, partnerships, overriding royalties, native title interests, historical sites, wilderness or national park and environmental settings.
  •  The security of the tenure held at the time of reporting along with any known impediments to obtaining a licence to operate in the area.

 

  •  The Shaakichiuwaanaan Property (formerly called “Corvette”) is comprised of 463 CDC claims located in the James Bay Region of Quebec, with Lithium Innova Inc. (wholly owned subsidiary of PMET Resources Inc.) being the registered title holder for all of the claims. The northern border of the Property’s primary claim block is located within approximately 6 km to the south of the Trans-Taiga Road and powerline infrastructure corridor. The CV5 Spodumene Pegmatite is accessible year-round by all-season road is situated approximately 13.5 km south of the regional and all–weather Trans-Taiga Road and powerline infrastructure. The CV13 and CV9 spodumene pegmatites are located approximately 3 km west-southwest and 14 km west of CV5, respectively.
  •  The Company holds 100% interest in the Property subject to various royalty obligations depending on original acquisition agreements. DG Resources Management holds a 2% NSR (no buyback) on 76 claims, D.B.A. Canadian Mining House holds a 2% NSR on 50 claims (half buyback for $2M), OR Royalties holds a sliding scale NSR of 1.5-3.5% on precious metals, and 2% on all other products, over 111 claims, and Azimut Exploration holds 2% NSR on 39 claims.
  •  The Property does not overlap any atypically sensitive environmental areas or parks, or historical sites to the knowledge of the Company. There are no known hinderances to operating at the Property, apart from the goose harvesting season (typically mid-April to mid-May) where the communities request helicopter flying not be completed, and potentially wildfires depending on the season, scale, and location.
  •  Claim expiry dates range from July 2026 to July 2028.

 

Exploration done by other parties

  •  Acknowledgment and appraisal of exploration by other parties.

 

  •  No previous exploration targeting LCT pegmatites has been conducted by other parties at the Project.
  •  For a summary of previous exploration undertaken by other parties at the Project, please refer to the most recent NI 43-101 Technical Report.

 

Geology

  •  Deposit type, geological setting and style of mineralization.

 

  •  The Property overlies a large portion of the Lac Guyer Greenstone Belt, considered part of the larger La Grande River Greenstone Belt and is dominated by volcanic rocks metamorphosed to amphibolite facies. The claim block is dominantly host to rocks of the Guyer Group (amphibolite, iron formation, intermediate to mafic volcanics, peridotite, pyroxenite, komatiite, as well as felsic volcanics). The amphibolite rocks that trend east-west (generally steeply south dipping) through this region are bordered to the north by the Magin Formation (conglomerate and wacke) and to the south by an assemblage of tonalite, granodiorite, and diorite, in addition to metasediments of the Marbot Group (conglomerate, wacke). Several regional-scale Proterozoic gabbroic dykes also cut through portions of the Property (Lac Spirt Dykes, Senneterre Dykes).
  •  The geological setting is prospective for multiple commodities over several different deposit styles including orogenic gold (Au), volcanogenic massive sulphide (Cu, Au, Ag), komatiite-ultramafic (Au, Ag, PGE, Ni, Cu, Co), and LCT pegmatite (Li, Cs, Ta, Ga, Rb).
  •  Exploration of the Property has outlined three primary mineral exploration trends crossing dominantly east-west over large portions of the Property – Golden Trend (gold), Maven Trend (copper, gold, silver), and CV Trend (lithium, caesium, tantalum). The CV4, CV5, CV8, CV12, and CV13 pegmatites are situated within the CV Trend.
  •  The pegmatites at Shaakichiuwaanaan are categorized as Li-Cs-Ta (“LCT”) pegmatites. LCT mineralization at the Property is observed to occur within quartz-feldspar pegmatite. The pegmatite is often very coarse-grained and off-white in appearance, with darker sections commonly composed of mica and smoky quartz, and occasional tourmaline.
  •  Core assays and ongoing mineralogical studies, coupled with field mineral identification and assays confirm spodumene as the dominant lithium-bearing mineral on the Property, with no significant petalite, lepidolite, lithium-phosphate minerals, or apatite present. The spodumene crystal size of the pegmatites is typically decimeter scale, and therefore, very large. The pegmatites also carry significant tantalum (tantalite) and caesium (pollucite). Gallium is present in spodumene and feldspar via substitution with Al. 

 

Drill hole Information

  •  A summary of all information material to the understanding of the exploration results including a tabulation of the following information for all Material drill holes:
    • easting and northing of the drill hole collar
    • elevation or RL (Reduced Level – elevation above sea level in metres) of the drill hole collar
    • dip and azimuth of the hole
    • down hole length and interception depth
    • hole length.
  •  If the exclusion of this information is justified on the basis that the information is not Material and this exclusion does not detract from the understanding of the report, the Competent Person should clearly explain why this is the case. 

 

  •  N/A. No drill results reported.

 

Data aggregation methods

  •  In reporting Exploration Results, weighting averaging techniques, maximum and/or minimum grade truncations (eg cutting of high grades) and cut-off grades are usually Material and should be stated.
  •  Where aggregate intercepts incorporate short lengths of high grade results and longer lengths of low grade results, the procedure used for such aggregation should be stated and some typical examples of such aggregations should be shown in detail.
  •  The assumptions used for any reporting of metal equivalent values should be clearly stated. 

 

  •  N/A. No drill results reported.

 

Relationship between mineralization widths and intercept lengths

  •  These relationships are particularly important in the reporting of Exploration Results.
  •  If the geometry of the mineralization with respect to the drill hole angle is known, its nature should be reported.
  •  If it is not known and only the down hole lengths are reported, there should be a clear statement to this effect (eg ‘down hole length, true width not known’).

 

  •  N/A. No drill results reported.

 

Diagrams

  •  Appropriate maps and sections (with scales) and tabulations of intercepts should be included for any significant discovery being reported. These should include, but not be limited to a plan view of drill hole collar locations and appropriate sectional views.

 

  •  Please refer to the figures included herein as well as those posted on the Company’s website.

 

Balanced reporting

  •  Where comprehensive reporting of all Exploration Results is not practicable, representative reporting of both low and high grades and/or widths should be practiced to avoid misleading reporting of Exploration Results.

 

  •  Reporting is balanced.  

 

Other substantive exploration data

  •  Other exploration data, if meaningful and material, should be reported including (but not limited to): geological observations; geophysical survey results; geochemical survey results; bulk samples – size and method of treatment; metallurgical test results; bulk density, groundwater, geotechnical and rock characteristics; potential deleterious or contaminating substances.

 

  •  The Company is currently completing site environmental work over the CV5 and CV13 pegmatite area. No endangered flora or fauna have been documented over the Property to date, and several sites have been identified as potentially suitable for mine infrastructure.
  •  The Company has completed a bathymetric survey over the shallow glacial lake which overlies a portion of the CV5 Spodumene Pegmatite. The lake depth ranges from <2 m to approximately 18 m, although the majority of the CV5 Spodumene Pegmatite, as delineated to date, is overlain by typically <2 to 10 m of water.
  •  The Company has completed significant metallurgical testing comprised of HLS and magnetic testing, which has produced 6+% Li2O spodumene concentrates at >70% recovery on both CV5 and CV13 pegmatite material. A DMS test on CV5 Pegmatite material returned a Subsequent and more expansive DMS pilot programs completed, including with non-pegmatite dilution, produced results in line with prior testwork, confirming a DMS-only flowsheet is applicable. Piloting to date (using both drill core and boulders) has collectively produced over 4.5 tonnes of spodumene concentrate grading over 5.5% Li2O.
  •  The Company has also produced a marketable lithium hydroxide concentrate from CV5’s spodumene concentrate.
  •  The Company has produced marketable tantalite concentrates at bench-scale from the CV5 Pegmatite’s DMS (spodumene) tailings fractions. The testwork used gravity or gravity + flotation methods to produce tantalite concentrates grading 8.7% Ta2O5 at 45% global recovery (MC001) and 6.6% Ta2O5 at 49% global recovery (MC002).
  •  The Company has produced marketable pollucite concentrates at bench-scale from the CV13 Pegmatite’s Vega Caesium Zone. The testwork used XRT ore sorting to produce concentrates of 11.5% Cs2O and 20.0% Cs2O at an overall 88% recovery.
  •  Various mandates required for advancing the Project have been completed or are ongoing, including but not limited to, environmental baseline, metallurgy, geomechanics, hydrogeology, hydrology, stakeholder engagement, geochemical characterization, as well as transportation and logistical studies. A Feasibility Study for lithium-only on the CV5 Pegmatite was announced October 20, 2025.
  •  The Company has produced battery-grade lithium carbonate (Li2CO3) at bench scale through the ALi® process at the independent laboratory ALS Metallurgy in Perth, Western Australia. Lithium recovery from DMS concentrate to final product was 92.5%.

 

Further work

  •  The nature and scale of planned further work (eg tests for lateral extensions or depth extensions or large-scale step-out drilling).
  •  Diagrams clearly highlighting the areas of possible extensions, including the main geological interpretations and future drilling areas, provided this information is not commercially sensitive.

 

  •  The Company intends to continue drilling the pegmatites of the Shaakichiuwaanaan Property, primarily targetting lithium, caesium, and tantalum as the primary commodities of interest. This is anticipated to includes step-out and infill drilling.
  •  Further drilling is anticipated to support the development of the CV5 and CV13 pegmatites (i.e., resource, geotechnical, geomechanical, and hydrogeological).
  •  Metallurgical test programs evaluating the recovery of lithium, caesium, and tantalum are ongoing.
  •  Surface prospecting, rock sampling, and mapping is planned to continue across the Property focused on LCT pegmatite.

 

APPENDIX 1

Phase 1: Options Assessment

Seven flowsheet options were evaluated across three processing routes (Acid Roast, Pressure Leach and Atmospheric Leach) as well as three different products (lithium carbonate, lithium sulfate and lithium phosphate).

Phase 1 provided a concept level comparison of all process options, with the goal of narrowing down options to progress to a Phase 2, focused on detailed refinement of product pathways.

The seven (7) options were evaluated using a multi-factor analysis using a combination of qualitative and quantitative factors:

  • CapEx;
  • OpEx;
  • Product and Reagents Logistics;
  • Reagent Sourcing and Availability;
  • Technology Maturity;
  • Recovery Risk;
  • Flowsheet complexity;
  • Product marketing;
  • Residue Handling;
  • Labour Availability.

The major project drivers – such as CAPEX, OPEX, technology maturity, product and reagent logistics and reagent sourcing – were assigned heavier relative weighting to reflect their increased influence on project viability. The remaining categories were considered secondary categories and assessed using a lighter relative weighing. Quantitative metrics were scored proportionally based on relative performance across the options, while qualitative criteria were evaluated using engineering judgement informed by industry precedent and operational experience.

Phase 1 shortlisted two lithium carbonate pathways to be advanced to the next stage for more detailed analysis; the Atmospheric Leach process achieved the highest score, with the Acid Roast process coming in second place.

Phase II: Concept Study

The Phase 2 design basis built upon the Phase 1 assumptions while incorporating updated process parameters. While Phase 1 assigned 100% lithium recovery to all options for concept–level comparability and to isolate CAPEX/OPEX and logistics differences, Phase 2 introduced more realistic recovery assumptions, with a lower recovery applied to the Atmospheric Leach option to account for the novel technology. This assumption affects consumptions, product mass, and trucking requirements.

Phase II Outcomes

Due to the preliminary nature of the Concept Study, Australian disclosure law prohibits the Company from presenting potential production and economic scenarios. Further detailed work is required before such information can be presented (see Next Steps – PEA Study above).

The reagent quantities were estimated using the refined recoveries and material balances and the logistics were re-evaluated for Phase 2, calculating the inbound (reagents) and outbound (product) transportation requirements for both options for comparison against the outbound-only transportation requirements of the spodumene concentrate (base case).

The Study outlined that, beyond the expected reduction in transportation costs due to the inherent significant drop in volume from concentrate to carbonate, the two options could capture varying degrees of synergies between outbound trucks leaving site with product and returning to site with reagents, synergies that do not exist under the base case where spodumene concentrate trucks leave the mine site full and return empty.

Based on the above, the Study concluded that introducing value-added products at the mine site could significantly reduce transport and logistics costs, given the total tonnage of material to transport (both reagents and product) would be substantially reduced, leading to a natural reduction of the number of trucks on the road on a daily basis.

The Atmospheric Leach option was found to deliver the strongest overall performance in the areas that most influence long-term project value, delivering the lowest capital costs, operating costs, reagent and trucking burden, HSE and environmental risks and the shortest payback period with the highest potential financial return.

Although the Acid Roast option benefits from greater process maturity and existing industrial references, these advantages are outweighed by its higher reagent demand, increased logistics requirements, more complex residue management, and higher sensitivity to market and operating conditions.

1

See Feasibility Study news release dated October 20, 2025.

2

See news release « PMET Produces High Recovery (89%) and High Grade Spodumene Concentrate (6.1% Li2O) from Innovative CV5 Sample and DMS Pilot Program » dated May 3, 2026.

3

https://www.chinesestandard.net/PDF-EN/YST582-2023EN-P10P-H7920H-642640.pdf 

4

See Feasibility Study news release dated October 20, 2025. Probable Mineral Reserve cut-off grade is 0.40% Li2O (open-pit) and 0.70% Li2O (underground). Underground development and open-pit marginal tonnage containing material above 0.37% Li2O are also included in the statement. Effective Date of September 11, 2025.

5

The Consolidated MRE (CV5 + CV13 pegmatites), which includes the Rigel and Vega caesium zones, totals 108.0 Mt at 1.40% Li2O, 0.11% Cs2O, 166 ppm Ta2O5, and 66 ppm Ga, Indicated, and 33.4 Mt at 1.33% Li2O, 0.21% Cs2O, 155 ppm Ta2O5, and 65 ppm Ga, Inferred, and is reported at a cut-off grade of 0.40% Li2O (open-pit), 0.60% Li2O (underground CV5), and 0.70% Li2O (underground CV13). A grade constraint of 0.50% Cs2O was used to model the Rigel and Vega caesium zones. The Effective Date is June 20, 2025 (through drill hole CV24-787). Mineral Resources are not Mineral Reserves as they do not have demonstrated economic viability. Mineral Resources are inclusive of Mineral Reserves.

 

 

Menarini Group Reports Data from the Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis at The European Hematology Association (EHA) 2026 Congress

  • The combination of selinexor plus ruxolitinib met the first co-primary endpoint demonstrating a statistically significant improvement of spleen volume reduction (SVR35) of 49.8% for the combination arm vs 28% for the control arm at week 24.
  • Post-hoc analysis from the phase 3 SENTRY trial suggests SVR35 may predict overall survival (OS); new data from the phase 1 SENTRY trial demonstrates a similar finding.
  • Data selected by EHA’s Scientific Program Committee for late-breaking oral presentation.
  • Data stems from the pivotal study conducted in collaboration with Karyopharm Therapeutics, Inc.

FOR MEDICAL AND PHARMACEUTICAL TRADE MEDIA ONLY

FLORENCE, Italy and NEW YORK, June 14, 2026 /PRNewswire/ — The Menarini Group (“Menarini”), a leading international pharmaceutical and diagnostics company, and Stemline Therapeutics, Inc. (“Stemline”), a wholly-owned subsidiary of the Menarini Group focused on bringing transformational oncology treatments to cancer patients, announced that new data related to the pivotal Phase 3 SENTRY trial will be presented as a late-breaking oral[i] at The European Hematology Association (EHA) 2026 Congress.

SENTRY (NCT04562389), a pivotal Phase 3 trial, is a randomized, double-blind, placebo-controlled trial of 60 mg selinexor in combination with ruxolitinib in frontline myelofibrosis (MF) (n=353), versus ruxolitinib monotherapy. Conducted by Karyopharm Therapeutics, Inc., in collaboration with the Menarini Group, SENTRY was designed to evaluate two co-primary endpoints: spleen volume reduction of 35% or more (SVR35) and absolute total symptom score (Abs-TSS).

The trial met the first co-primary endpoint, demonstrating that patients who were treated with the combination of selinexor plus ruxolitinib achieved a clear and statistically significant improvement in SVR35, compared to patients who received ruxolitinib alone. These results highlight that the combination arm enabled rapid, deep and sustained spleen volume reductions.

selinexor plus ruxolitinib (n=235)

placebo + ruxolitinib (n=118)

SVR35 at week 12

49.4% (n=116)

20.3% (n=24)

SVR35 at week 24

49.8% (n=117)

28.0% (n=33)

SVR35 at week 36*

46.9% (n=97)

23.0% (n=23)

*Analysis conducted in those patients who completed a spleen assessment or discontinued the study prior to week 36

“Achievement of spleen reduction is the essential goal of myelofibrosis treatment. Importantly, the spleen reduction results seen in SENTRY were rapid, deep and durable, and associated with potential overall survival benefit for the patients receiving the combination,” said Dr. Claire Harrison, Professor of Myeloproliferative Neoplasms and Deputy Chief Medical Officer at Guy’s and St. Thomas’ NHS Foundation Trust. “We are encouraged that these results represent a potential new therapeutic advance for our patients who are in dire need of better options.”

Other key highlights include:

  • Absolute Total Symptom Score (Abs-TSS): The combination arm demonstrated a comparable benefit to ruxolitinib alone, with a 9.9 point improvement in Abs-TSS at week 24, in patients who received the combination, compared to a 10.9 point improvement in patients who received ruxolitinib alone. The difference across the two arms was not statistically significant, and the combination arm did not meet this second co-primary endpoint.
  • Overall Survival (OS): While these data were immature at the time of analysis, a promising early OS signal, a pre-specified secondary endpoint, was observed with the selinexor combination compared to ruxolitinib alone. The study showed a greater than 50% reduction in the risk of death for patients receiving the selinexor combination (HR 0.43).
  • Spleen Volume Reduction: Consistent SVR35 benefit was observed across prespecified subgroups. Notably, at week 24, superior spleen volume reduction was achieved by the selinexor combination, regardless of the ruxolitinib dose, including by patients receiving less than 15 mg of ruxolitinib per day.
  • Variant Allele Frequency (VAF) Reduction: This pre-specified exploratory endpoint, which is associated with SVR35, was observed in 32% of patients in the selinexor plus ruxolitinib arm at week 24 versus 23.9% of patients treated with ruxolitinib alone, indicating the combination’s potential for disease modification.
  • Safety and Tolerability: The combination demonstrated a manageable safety and tolerability profile consistent with the known profile of selinexor and ruxolitinib individually. No new safety signals were observed.

“The strength of the spleen response and the encouraging early overall survival data observed in the SENTRY study creates hope for a potential new treatment option for patients suffering from this devastating disease with dismal outcomes,” said Elcin Barker Ergun, CEO of the Menarini Group. “Our dedication and commitment to bring transformational treatments to patients facing cancer is stronger than ever.”

About Myelofibrosis (MF)

Myelofibrosis (MF) is a type of blood cancer that belongs to a group of diseases called Myeloproliferative Neoplasms (MPNs). These diseases are caused by the overgrowth of abnormal blood-forming cells in the bone marrow, which leads to the formation of scar tissue. This scarring makes it difficult for the body to produce healthy blood cells. The incidence of MF is rare, with only about one or two people diagnosed each year for every 100,000 individuals, and the median survival after diagnosis is six years. Additionally, for people living with MF, their quality of life can be compromised by symptoms including fatigue, an enlarged spleen, and low blood counts, all of which are caused by the disease. 1,2,3

To report SUSPECTED ADVERSE REACTIONS, contact Stemline Therapeutics, Inc. at adverseevents@menarinistemline.com. All of the relevant information can be found at https://stemline.com/contact/

Please see Summary of Product Characteristics (SmPC) and European Public Assessment Report at www.ec.europa.eu.

Please refer to local prescribing information where selinexor is approved for full information. Menarini Group holds licensing rights for selinexor and currently markets it in numerous European countries and global territories. In the U.S., Karyopharm Therapeutics markets selinexor and the full prescribing information is available here.

About The Menarini Group

The Menarini Group is a leading international pharmaceutical and diagnostics company, with a turnover of $5.5 billion and over 17,000 employees. Menarini is focused on therapeutic areas with high unmet needs with products for cardiology, oncology, pneumology, gastroenterology, infectious diseases, diabetology, inflammation, and analgesia. With 18 production sites and 9 Research and Development centers, Menarini’s products are available in 140 countries worldwide. For further information, please visit www.menarini.com.

About Stemline Therapeutics Inc.
Stemline Therapeutics, Inc. (“Stemline”), a wholly-owned subsidiary of the Menarini Group, is a commercial-stage biopharmaceutical company focused on bringing transformational oncology treatments to patients. Stemline commercializes elacestrant, an oral endocrine therapy indicated for the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy, in the U.S., Europe, and other global regions. Stemline also commercializes tagraxofusp-erzs, a novel targeted therapy directed to CD123, for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic cancer, in the United States, Europe, and other global regions. In addition, Stemline commercializes selinexor, an XPO1 inhibitor for multiple myeloma, in Europe. The company is also conducting multiple label-expansion studies with elacestrant and tagraxofusp in breast and hematologic cancer indications, respectively, and has an extensive clinical pipeline of additional drug candidates in various stages of development for a host of solid and hematologic cancers.

References

1.  Myelofibrosis. NORD (National Organization for Rare Disorders). https://rarediseases.org/mondo-disease/myelofibrosis/
2.  Myelofibrosis. The Leukemia & Lymphoma Society (LLS). https://bloodcancerunited.org/blood-cancer/myeloproliferative-neoplasms-mpns/myelofibrosis-mf
3.  Myelofibrosis. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/myelofibrosis/symptoms-causes/syc-20355057

[i] The safety and efficacy of the investigational combinations and unapproved indications discussed in this press release have not been established by the FDA, EMA, or any other regulatory authority.