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Monport AutoForge Goes Live on Kickstarter to Bring Automation and Speed for Every Engraving Project

NEW YORK, Aug. 19, 2025 /PRNewswire/ — Monport Laser today launched AutoForge, the world’s first auto-load laser engraver designed to make metal business card engraving, bulk tag production, and customized gifts faster and easier than ever before. Now live on Kickstarter, AutoForge blends automation, batch processing, and multi-laser precision to give small businesses, workshops, and makers a true competitive edge.

Back AutoForge on Kickstarter today.

Hands-Free Metal Business Card Engraving

With its AutoLoad + AutoFlow system, AutoForge is a breakthrough for engraving machines used for metal business cards. Users can stack stainless steel or aluminum blanks, and AutoForge automatically loads, aligns, and engraves each card with perfect accuracy.

This means:

  • Batch metal business card engraving without manual resets
  • High-speed engraving at 10,000 mm/s on a 230 × 230 mm work area
  • Consistent, professional finishes across hundreds of engraved business cards

Whether for corporate branding, luxury business cards, or bulk promotional projects, AutoForge delivers production-line efficiency in a single compact system.

See AutoForge engrave metal business cards in action here: Monport AutoForge Preview

Three Configurations for Every Laser Engraving Project

AutoForge adapts to different industries and projects beyond metal business card engraving:

  • AutoForge XPro (Dual Laser) – A 30W Fiber Laser for deep metal engraving (ideal for business cards, dog tags, and industrial labels) plus a 20W Diode Laser for wood, leather, and non-coated metals.
  • AutoForge MOPA 60W – Specializes in color engraving with 100+ vibrant hues on stainless steel, titanium, and anodized aluminum business cards.
  • AutoForge UV 5W – Perfect for glass gifts, subsurface crystal work, and fine engraving on plastics.

Compare AutoForge models & configurations: Monport AutoForge Details

Why AutoForge Stands Out in Metal Business Card Production

Unlike traditional fiber laser engraving machines, AutoForge is the only laser engraver with an automated material handling system. For metal business card engraving, this means businesses no longer need to manually position each blank — the machine does the heavy lifting.

Key advantages include:

  • One-click batch engraving of hundreds of business cards in a single run
  • Multi-feeder support for simultaneous engraving
  • ForgeSight Align + SafeLaser Preview for pin-point precision on small surfaces
  • Scalability — from engraving a dozen samples to fulfilling bulk orders

Start your journey into automated metal business card engraving: Back AutoForge on Kickstarter

Real-World Business Impact

AutoForge isn’t just a machine — it’s a growth tool. Small engraving shops can produce hundreds of premium metal business cards per day without adding labor costs, while marketing agencies can offer luxury engraved business cards as a high-value service. Jewelry makers, promotional product suppliers, and corporate branding firms can also tap into AutoForge’s batch automation to increase output and margins.

By combining fiber laser power for metal business card engraving with the versatility of diode and UV lasers, AutoForge enables entrepreneurs to expand their product lines and enter new markets with ease.

Discover how AutoForge can grow your business: Learn More at Monport Laser

Kickstarter Launch & Early Bird Pricing

Monport is rewarding its earliest backers with unbeatable Kickstarter-only deals. Each reward tier is capped at just 50 units—once they’re gone, the next pricing stage unlocks automatically. Secure your AutoForge now before the discounts disappear.

  • AutoForge XPro – Dual-Laser (30W Fiber + 20W Diode) – $3,299 retail
    • Super Early Bird – $2,199 (Save 33%)
    • Early Bird – $2,399 (Save 27%)
    • Kickstarter Special – $2,699 (Save 18%)
  • AutoForge MOPA 60W$5,999 retail
    • Super Early Bird – $3,999 (Save 33%)
    • Early Bird – $4,199 (Save 30%)
    • Kickstarter Special – $4,599 (Save 23%)
  • AutoForge UV 5W –  $5,999 retail
    • Super Early Bird – $3,999 (Save 33%)
    • Early Bird – $4,199 (Save 30%)
    • Kickstarter Special – $4,599 (Save 23%)

Remember: Each stage is limited to 50 backers only. When the 50th unit is gone, the next backer automatically moves to the higher tier price.

Secure your AutoForge now on Kickstarter.

About Monport Laser

Monport Laser is a leading innovator in engraving technology, specializing in fiber, CO2, and UV systems for professionals and businesses worldwide. With AutoForge, Monport redefines laser engraving for metal business cards and beyond, combining automation, scalability, and precision in one revolutionary machine.

Media Contact

Company: Monport Laser
Email: official@monportlaser.com
Website: https://www.monportlaser.com/

Lisbon Welcomes Global Icons to Crypto Content Creator Campus 2025: Nuseir Yassin, Dr. Maye Musk, and More to Lead the Stage

DUBAI, UAE, Aug. 19, 2025 /PRNewswire/ — The Crypto Content Creator Campus (CCCC) Lisbon 2025 is gearing up for its most star-studded edition yet. From November 14 to 16, Europe’s rising blockchain capital will host an ensemble of global visionaries who are redefining storytelling and influence like Nuseir Yassin, Nick Tran, Philippe Ben Mohamed, and Sergej Loiter. In addition, Dr. Maye Musk will be sharing her experience on content creation, modeling and stories from her book “A Woman Makes A Plan”.

With the theme “Monetization in the Web3 Era”, this three-day experience will unite content creators, influencers, and innovators from around the globe to explore how blockchain, crypto, and the creator economy intersect to unlock new income streams.

Lisbon Welcomes Global Icons to Crypto Content Creator Campus 2025: Nuseir Yassin, Dr. Maye Musk, and More to Lead the Stage
Lisbon Welcomes Global Icons to Crypto Content Creator Campus 2025: Nuseir Yassin, Dr. Maye Musk, and More to Lead the Stage

From Inspiration to Implementation

Attendees will have the rare opportunity to learn directly from some of the world’s most influential voices:

  • Nuseir Yassin, Founder and Content Creator of NasDaily — The global storyteller who built a community of 70M+ followers through viral content that educates and inspires, now exploring the frontiers of Web3 storytelling.
  • Dr. Maye Musk — International supermodel, dietitian, and best-selling author, whose advocacy for innovation and technology continues to inspire the next generation of changemakers.
  • Nick Tran — The former TikTok Global Head of Marketing and CMO of Web3 brands, renowned for building brands that dominate digital culture.
  • Musa Tariq – Former Marketing Executive @ Airbnb, Apple & Nike
  • Philippe Ben Mohamed, Head of Metaverse at Tomorrowland
  • Sergej Loiter — CEO of Search, AI, and AdTech, Yango Group

“The Web3 world is rewriting the rules for how stories are told, shared, and rewarded. I can’t wait to connect with creators in Lisbon and explore how they can turn their voices into global movements — and revenue streams.”

— Nuseir Yassin, Founder and Content Creator of NasDaily

“Innovation has no age limit. At CCCC Lisbon, I look forward to showing creators how embracing new technologies can open up unexpected paths to success and impact.”

— Dr. Maye Musk, Author & Speaker

A Call to All Crypto Content Creators

Whether you are a Web3 influencer, NFT artist, crypto trader, or community builder, CCCC Lisbon 2025 is your chance to gain insider strategies, network with the biggest names in the space, and future-proof your creative career.

Event Details:

Join the conversation online at #CCCCLisbon and be part of the global movement empowering creators in the decentralized era.

About Crypto Content Creator Campus (CCCC)

CCCC is a team of industry experts and visionaries committed to shaping the future of content creation within the Web3 and crypto sphere. Driven by a shared passion for creating a high-value community, we’ve curated a campus that promises an experience unlike any other.  The CCCC 2025 will be held in Lisbon, Portugal, from November 14 to 16, 2025.

For more details about CCCC, please visit: https://www.cccc.buzz/

For inquiries, please contact: hello@cccc.buzz

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Anycubic at 10: A Decade Forged by Makers, Inspired by Users

SHENZHEN, China, Aug. 19, 2025 /PRNewswire/ — Anycubic celebrates its 10th anniversary this year, marking a decade of growth from a small Shenzhen startup into a trusted companion for millions of creators across more than 200 countries. This journey has been defined not only by technology, but by listening to and evolving with its users.

Anycubic at 10: A Decade Forged by Makers, Inspired by Users
Anycubic at 10: A Decade Forged by Makers, Inspired by Users

Listening, Learning, Evolving

The journey hasn’t been about leaps alone, but about listening—to educators, artists, engineers, and hobbyists. Products such as the Photon resin series and the Kobra FDM line were shaped through extensive feedback and iteration. The introduction of technologies like the ACE Pro, with its multi-color capabilities and seamless stability, came not from a lab alone, but from conversations with makers who needed more from their tools.

Today, over 4.4 million Anycubic printers power classrooms, studios, and workshops worldwide—not as finished answers, but as starting points for ideas yet to be imagined.

A Celebration of Community

To honor this milestone, Anycubic is gathering with its global community:

  • A Global AMA on Reddit (Aug 19–23), where leaders including CTO James Ouyang, VP Ancen Zhang, and Technical Manager Barry will engage in open dialogue with users.
  • A 10th Anniversary Meet-Up in Istanbul (Aug 21), bringing together local users, partners, and creators to share stories and inspiration.

Looking Forward: The Anycubic Dream

The next decade begins with the “Anycubic Dream” initiative—a 10-year global program to donate 10,000 printers to educators, makers, and innovators, especially those who might not otherwise have access. Participants will be invited to share their visions and join a growing network of Anycubic Dreamers, showing how imagination and technology together can create real impact.

This vision is reinforced by the MakerOnline platform, where challenges like Color Our World 2.0 encourage creators to connect, collaborate, and showcase their work.

The challenge runs until August 29, with cash prizes and Anycubic printers awaiting the most creative entries. 

“Ten years feels less like an endpoint and more like a foundation,” said James Ouyang, co-founder and CTO of Anycubic. “What we’ve built so far is only a preview of what this community can do.”

With Gratitude

As a thank-you, Anycubic is launching 10th Anniversary promotions, community activities, and creative campaigns—an invitation to makers everywhere to keep building the future, together.

About Anycubic

Founded in 2015, Anycubic has grown into one of the world’s leading 3D printing companies, serving millions of users in over 200 countries and regions. Known for its innovative and reliable machines, Anycubic empowers creators everywhere to transform ideas into reality.

Michter’s Continues Its Toasted Barrel Finish Series With Launch of 2025 Michter’s US*1 Toasted Barrel Finish Sour Mash

LOUISVILLE, Ky., Aug. 19, 2025 /PRNewswire/ — This September, Michter’s will release its US*1 Toasted Barrel Finish Sour Mash Whiskey. This whiskey is part of Michter’s series of whiskeys finished in toasted uncharred barrels.

Michter’s Continues Its Toasted Barrel Finish Series With Launch of 2025 Michter’s US*1 Toasted Barrel Finish Sour Mash
Michter’s Continues Its Toasted Barrel Finish Series With Launch of 2025 Michter’s US*1 Toasted Barrel Finish Sour Mash

“In 2014 our Michter’s team didn’t realize that we were putting the Toasted Uncharred Barrel Finish category on the map when we released our bourbon finished in a second barrel that was toasted but not charred and named it Toasted Barrel Finish Bourbon,” stated Michter’s President Joseph J. Magliocco. “This 2025 release of Michter’s US*1 Toasted Barrel Finish Sour Mash Whiskey is really special.”

The 2025 release of Michter’s Toasted Barrel Finish Sour Mash Whiskey follows on the heels of releases of Michter’s Toasted Barrel Finish Bourbon and Michter’s Toasted Barrel Finish Rye. “At Michter’s, we value American whiskey making traditions, but we are always experimenting and looking for innovative ways to make great whiskeys. We’re proud that we were able to show how good fully matured whiskey finished in a second barrel that was toasted but not charred can be. The second toasted only barrel really complements the flavors of the Sour Mash and deepens the rich honey, burnt sugar, and citrus spice notes with smoky vanilla reminiscent of a cozy campfire,” observed Michter’s Master of Maturation Andrea Wilson.

Like the highly acclaimed Michter’s US*1 Sour Mash, which in 2019 earned the honor of being the first American whiskey named Whisky of the Year by UK-based The Whisky Exchange, Michter’s US*1 Toasted Barrel Finish Sour Mash is 86 proof (43% ABV). Its U.S. suggested retail price is $110 per 750ml bottle.

Michter’s Master Distiller Dan McKee commented, “Our Sour Mash Whiskey is an interesting whiskey that has the attributes of a really good bourbon yet finishes a bit like a rye. It’s a whiskey that is a terrific candidate for finishing in the second barrel that is toasted but not charred.”

In October 2024, Michter’s became the first whiskey to be named in two consecutive years The World’s Most Admired Whiskey by a vote of an international academy of voters announced by UK-based Drinks International. Michter’s has a rich and long legacy of offering traditional American whiskeys of uncompromising quality. With each of its limited production offerings aged to its peak maturity, Michter’s highly acclaimed portfolio includes bourbon, rye, sour mash whiskey, and American whiskey. For more information about Michter’s, please visit michters.com and follow us on Instagram, Facebook, and X.

Contact:
Joseph J. Magliocco
+1 (502) 774-2300 x580
jmagliocco@michters.com

 

Dream Pairs Expands Retail Footprint with New Multi-Brand Store in Long Island, NY

NEW YORK, Aug. 19, 2025 /PRNewswire/ — Dream Pairs, the leading fashion-forward footwear brand under Miracle Miles Group Inc., is stepping into a new chapter with the launch of a multi-brand retail store in Lake Grove, New York. Opening on August 15, 2025, the store marks Miracle Miles’ first location in Long Island and its sixth across the country. More than just a new storefront, it’s a full showcase of the group’s growing brand portfolio—including Dream Pairs, Bruno Marc, NORTIV 8, ALLSWIFIT, and Dream Pairs Kids—uniting fashion, function, and family in one dynamic shopping destination.

Dream Pairs, under Miracle Miles Group Inc., is opening its first Long Island multi-brand retail store at Smith Haven Mall, showcasing its full brand portfolio—including Dream Pairs, Bruno Marc, NORTIV 8, ALLSWIFIT, and Dream Pairs Kids. The new location marks a key step in Dream Pairs' and Miracle Miles’ expansion from online success to immersive in-store experiences.
Dream Pairs, under Miracle Miles Group Inc., is opening its first Long Island multi-brand retail store at Smith Haven Mall, showcasing its full brand portfolio—including Dream Pairs, Bruno Marc, NORTIV 8, ALLSWIFIT, and Dream Pairs Kids. The new location marks a key step in Dream Pairs’ and Miracle Miles’ expansion from online success to immersive in-store experiences.

More than just a shoe store, this new location is a vibrant, hands-on shopping destination where families, fashion-lovers, commuters, and outdoor explorers alike can discover a wide variety of affordable, high-quality footwear—all in one place. From stylish heels to rugged hiking boots, this store is where fashion meets function and comfort meets choice.

All Together, All in Dream Pairs

Dream Pairs is closer to you than ever before—with the grand opening of its very first Long Island store at Smith Haven Mall. This isn’t just another shoe store; it’s a vibrant, must-visit destination designed to redefine everyday footwear for the whole family. From casual days to big adventures, Dream Pairs brings style, comfort, and real-life functionality all under one roof—right where Long Island families live, work, and play.

Step inside and discover a uniquely curated collection that blends fashion with function, comfort with durability, and style with heart. This one-stop shop features all five standout brands from the Miracle Miles Group portfolio, each tailored to meet your family’s diverse needs:

  • Dream Pairs – Where fashion meets fearless comfort. Dream Pairs delivers trendy, affordable footwear that empowers you to express your style confidently—whether you’re stepping out in casual sneakers or statement boots. Every pair is thoughtfully crafted to keep you comfortable and chic from morning till night.
  • Bruno Marc – The ultimate expression of masculine elegance. Bruno Marc creates impeccably refined men’s shoes from premium materials, blending timeless style with exceptional comfort. Designed for the confident man who demands both sophistication and durability.
  • NORTIV 8 – Built to perform and engineered to last. NORTIV 8 delivers rugged, high-performance footwear designed to withstand the toughest conditions—protecting and empowering workers and adventurers alike. When durability meets innovation, unstoppable performance follows.
  • ALLSWIFIT – Engineered for an active, on-the-go lifestyle, ALLSWIFIT offers lightweight, breathable, and flexible athleisure footwear that encourage natural movement and deliver all-day comfort. Stylish and functional, it’s the perfect choice for those who push their pace every day.
  • Dream Pairs Kids –Where trusted quality meets playful style for growing feet. Dream Pairs Kids creates durable, comfortable shoes designed to support every step—whether it’s playground fun or everyday adventures—keeping little feet happy and ready to explore.

From toddlers to teens, from professionals to weekend explorers, Dream Pairs at Smith Haven Mall is your go-to destination for footwear that fits every member of the family—and every moment of life. Walk in for unmatched comfort. Walk out with unbeatable value. All together, all in—because family style is better when it’s shared.

Grand Opening Specials

Dream Pairs is thrilled to invite the community to celebrate the grand opening on August 15th with exclusive in-store offers and fun-filled activities for all ages. At the heart of the celebration is the #LoveMoreSaveMore promotion—designed to make refreshing any footwear collection both easy and rewarding. Ideal for individuals, families, and friends alike, this special offer encourages mixing and matching across favorite styles and brands to unlock greater savings and spread the joy of new shoes with loved ones:

  • Buy 1 pair, get 15% off
  • Buy 2 pairs, get 20% off
  • Buy 3 pairs, get 30% off

(In-Store Only. Limited Time Offer.)

The celebration will also feature a live DJ, a selfie wall check-in, welcome gift bags (free tote bag for attendees), a lucky spin wheel for surprise prizes, take-home Polaroid moments to capture the excitement. Customers can also enjoy personalized fittings, style consultations, and hands-on demos of the latest collections throughout the day.

From Online Favorites to In-Store Destinations

Dream Pairs has captured the hearts of millions worldwide with its trend-driven, comfortable, and affordable footwear, making it one of the flagship brands within the Miracle Miles Group. With millions of pairs sold and consistently ranking among the top sellers on Amazon across a wide spectrum—from fashion sneakers and chic heels to cowboy boots and vibrant kids’ shoes—Dream Pairs has become synonymous with stylish, accessible footwear for everyday life.

Now, Dream Pairs is stepping beyond the digital space to offer an immersive, hands-on shopping experience at its new Smith Haven location. This expansion invites customers to engage directly with the brand—feeling the quality, trying on the perfect fit, and exploring the full breadth of styles in person.

This store opening marks a pivotal milestone in Miracle Miles’ ambitious strategy to seamlessly blend its thriving online presence with dynamic brick-and-mortar retail. By combining the convenience of e-commerce with the tactile, personalized experience of in-store shopping, Miracle Miles and Dream Pairs are redefining modern footwear retail—bringing style, innovation, and accessibility closer to home than ever before.

Powered by Innovation and Vision

The opening is part of a broader expansion strategy fueled by the group’s $100 million Series A funding round in 2022, led by IDG Capital and Sequoia Capital China. With strong investor confidence and accelerating momentum, Miracle Miles is scaling rapidly across retail, wholesale, and e-commerce—paving the way for a new era of accessible, elevated footwear. With technology as its engine and value creation at its core, Miracle Miles is on a mission to become the leading footwear brand group of choice for the global mass market.

Visit the Store

Come explore the new store at J12 313 Smith Haven Mall, Lake Grove, New York 11755 —or browse our full lineup of brands and styles online at www.dreampairs.com.

About Dream Pairs

Founded in 2009, Dream Pairs is committed to empowering women to express their unique style through fashion-forward footwear. The brand continually pushes the boundaries of modern women’s footwear by offering curated collections that combine trend-driven designs with everyday versatility — all at accessible prices. Inspired by runway styles and current trends, Dream Pairs makes fashion inclusive and approachable for all. Trusted by over 15 million customers worldwide, Dream Pairs has sold more than 30 million pairs of shoes and consistently ranks as a top seller across multiple categories on Amazon. With a growing network of brick-and-mortar stores and a strong online presence on platforms like Amazon, Walmart, Shein, Nordstrom, JustFab, and its official website, Dream Pairs delivers high-quality, fashionable footwear tailored for every occasion and every need, all at accessible prices.

About Miracle Miles Group Inc.

Miracle Miles Group Inc. is a global footwear company known for its innovative, accessible brands that serve millions worldwide. With a growing portfolio that includes Dream Pairs, Dream Pairs Kids, Bruno Marc, NORTIV 8, and ALLSWIFIT, the company delivers a broad range of footwear that blends fashion, performance, and everyday comfort. Committed to quality, style, and customer satisfaction, Miracle Miles continues to expand both online and offline, creating shoes that inspire confidence in every step. From casual wear to work boots, from city streets to outdoor trails, Miracle Miles designs footwear for every lifestyle— empowering people to move through life with comfort and purpose.

1inch pioneers Solana cross-chain swaps, unlocking seamless interoperability

  • 1inch now enables trustless, MEV-protected cross-chain swaps between Solana and 12+ EVM networks without relying on bridges and unsafe messaging protocols.
  • Users and developers can access new swaps via the 1inch dApp, Wallet, and Fusion+ API for seamless DeFi interoperability.

DUBAI, UAE, Aug. 19, 2025 /PRNewswire/ — 1inch, the leading DEX aggregator, launches industry-first native decentralized cross-chain swaps between Solana and all major EVM networks – without relying on bridges and messaging protocols. This milestone marks a major leap in 1inch’s mission to unify DeFi into one interoperable experience.


Solana cross-chain swaps are now live via the 1inch dApp, 1inch Wallet, and 1inch Fusion+ APIs. This release lets users seamlessly move assets between Solana and 12+ EVM chains in a secure, efficient, and MEV-protected way.

Why it matters

For the first time, users can swap assets directly between Solana and EVM networks, without using bridges. Key benefits are:

–  Bulletproof security: with no need for bridges or messaging protocols, this is the safest way to move assets onto and off Solana.
–  Seamless execution: allows users to sign and post their trade, letting resolvers compete to fulfill it under the best conditions.
–  The best rates: with unmatched liquidity and MEV protection by design.

Pioneering native decentralized cross-chain swaps

A few months ago, 1inch added support for Solana, leveraging its low-latency block times and robust ecosystem. Now, with full cross-chain capability, the fragmentation between Solana and EVM ecosystems is finally addressed.

“Solana’s speed and efficiency made it an ideal candidate for our next frontier in cross-chain swaps,” said Sergej Kunz, 1inch co-founder. “By removing the need for bridges and messaging protocols such as LayerZero or Chainlink CCIP, we’re delivering a fundamentally safer and smoother cross-chain experience.”

1inch’s cross-chain Solana functionality also delivers a significant boost to the entire Solana ecosystem, ending Solana’s isolation from other blockchains and transforming it into a full-fledged DeFi hub by bringing in new liquidity and users.

Solana tokens can now be traded directly against assets on EVM networks, opening the ecosystem to users who have never interacted with Solana before.

For users and builders alike

Solana cross-chain swaps are now fully supported across all 1inch products:

  • 1inch dApp – for seamless user-friendly swaps.
  • 1inch Wallet – for mobile-first users managing assets on the go.
  • 1inch Fusion+ API – enabling developers to integrate trustless Solana<>EVM swaps in their own projects.

This opens up new liquidity pathways and trading opportunities, allowing DeFi participants to operate across previously siloed ecosystems – with no extra steps.

What’s next

Meanwhile, 1inch’s mission to unify the DeFi space continues, with plans underway to add support for more non-EVM chains. The journey toward a more efficient and user-friendly DeFi experience moves forward!

About 1inch

1inch accelerates decentralized finance with a seamless crypto trading experience for 24M users. Beyond being the top platform for low-cost, efficient token swaps with $500M in daily trades, 1inch offers a range of innovative tools, including a secure self-custodial wallet, a portfolio tracker for managing digital assets, a developer portal to build on its cutting-edge technology, and even a debit card for easy crypto spending. By continuously innovating, 1inch is simplifying DeFi for everyone.

Website | Follow on X | Explore Blog

Mabwell’s CDH17-targeting ADC 7MW4911 Receives IND Clearance from FDA

SHANGHAI, Aug. 19, 2025 /PRNewswire/ — Mabwell (688062.SH), an innovative biopharmaceutical company with entire industry chain, announced that its self-developed CDH17-targeting ADC (R&D code: 7MW4911) received IND clearance from the U.S. Food and Drug Administration (FDA). The clearance enables the initiation of Phase I/II study of 7MW4911 to evaluate the safety, pharmacokinetics, and efficacy in patients with advanced colorectal cancer and other advanced gastrointestinal tumors.

7MW4911 is an investigational CDH17-targeting ADC developed using Mabwell’s proprietary IDDC™ platform. Its highly optimized structure integrates three key elements:

  • Mab0727: A highly specific CDH17 monoclonal antibody with rapid internalization properties, cross-species (human/monkey) moderate affinity, and minimal off-target binding.
  • Novel cleavable linker: Ensures precise payload release in tumor tissues.
  • MF-6 payload: A proprietary DNA topoisomerase I inhibitor designed to overcome multidrug resistance (MDR), exhibiting superior plasma stability, controlled drug release, and potent bystander effects.

In July 2025, Mabwell published preclinical data in Cell Reports Medicine (“Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor”), demonstrating 7MW4911’s tumor-selective cytotoxicity via CDH17-mediated internalization. Key advantages include:

  • Optimized molecular design: Homogeneous drug-to-antibody ratio (DAR=4, >95%) and stable linker confer exceptional plasma stability, while membrane-permeable MF-6 drives potent bystander killing.
  • Broad Antitumor Efficacy: Demonstrates robust tumor regression in colorectal, gastric, and pancreatic cancer PDX/CDX models, including tumors with RAS/BRAF mutations and diverse Consensus Molecular Subtypes (CMS).
  • MDR resistance: Outperforms MMAE/DXd-based ADCs in ABC transporter-mediated MDR models and reverses tumor progression post-ADC treatment.
  • Target versatility: Active even in tumors with low-to-moderate CDH17 expression, expanding potential patient eligibility.
  • Favorable safety profile: Limited tissue distribution in mice, controllable pharmacokinetics (moderate half-life, no accumulation), and a wide therapeutic window in cynomolgus monkeys, with no significant toxicity signals.

With this profile, 7MW4911 emerges as a promising therapeutic candidate for advanced gastrointestinal cancers. IND application of 7MW4911 has been accepted by China’s National Medical Products Administration (NMPA).

About CDH17

CDH17 is a pan-cancer validated target with restricted expression in normal intestinal epithelium but marked overexpression in gastrointestinal cancers (e.g., colorectal, gastric, pancreatic). Its aberrant expression correlates with tumor metastasis and poor prognosis, positioning it as an ideal therapeutic target.

About Mabwell

Mabwell (688062.SH) is an innovation-driven biopharmaceutical company with the entire value chain of the pharmaceutical industry. The company provides more effective and accessible therapy and innovative medicines to fulfill global medical needs, focusing on oncology and aging-related disease indications. Mabwell’s mission is “Explore Life, Benefit Health” and its vision is “Innovation, from ideas to reality”. For more information, please visit www.mabwell.com/en.

Forward-Looking Statements

This press release contains forward-looking statements including, but not limited to, the potential safety, efficacy, regulatory review or approval and commercial success of our product candidates and those relating to the Company’s product development, clinical studies, clinical and regulatory milestones and timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. “Forward-looking statements” are statements that are not historical facts and involve a number of risks and uncertainties, which may cause actual results to be materially different from any future results expressed or implied in the forward-looking statements. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would,” and similar expressions and the negatives of those terms.

Forward-looking statements are based on the Company’s current expectations and assumptions. Forward-looking statements are subject to a number of risks, uncertainties, and other factors, many of which are beyond the Company’s control, including, but not limited to: environment; politic; economy; society; legislation; our dependence on our product candidates, most of which are still in preclinical or various stages of clinical development; our reliance on third-party vendors, such as contract research organizations and contract manufacturing organizations; the uncertainties inherent in clinical testing; our ability to complete required clinical trials for our product candidates and obtain approval from regulatory authorities for our product candidates; our ability to protect our intellectual property; the potential impact of COVID-19; the loss of any executive officers or key personnel. In case one or more of these risks or uncertainties deteriorate, or any assumptions are incorrect, the actual results may be seriously inconsistent with the stated results.

The Company cautions all the persons not to place undue reliance on any such forward-looking statements, which speaks only as of the date of this press release. The Company disclaims any obligation, except as specifically required by law and the rules of the applicable Stock authority to publicly update or revise any such statements to reflect any change in expectations or in events, conditions, or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. All forward-looking descriptions, figures and assumptions in this press release are applicable to this statement.

Landis+Gyr Recognized by Frost & Sullivan as the 2025 Global Company of the Year for Excellence in Advanced Metering Infrastructure

The company is recognized for visionary innovation and customer impact in redefining metering infrastructure and enabling grid modernization through intelligent, real-time solutions.

SAN ANTONIO, Aug. 19, 2025 /PRNewswire/ — Frost & Sullivan is pleased to recognize Landis+Gyr as the 2025 Global Company of the Year in the Advanced Metering Infrastructure (AMI) sector for its outstanding achievements in visionary innovation and in customer impact. This distinction highlights Landis+Gyr’s consistent leadership in driving measurable outcomes, strengthening its market position, and delivering customer-centric innovation, marking the company’s ninth recognition by Frost & Sullivan in the AMI space since 2013.

Frost & Sullivan evaluates companies through a rigorous benchmarking process across two core dimensions: visionary innovation and customer impact. Landis+Gyr excels in both, demonstrating its ability to align strategic initiatives with market demand while executing them efficiently, consistently, and at scale. “By transforming each endpoint into a real-time intelligence node, Landis+Gyr bridges the gap between a utility’s physical infrastructure and its digital data systems—enabling not just visibility into what is happening at the grid edge, but also deep insight into why it is happening. This unified digital-physical grid architecture effectively addresses a long-standing blind spot in grid management—achieving comprehensive situational awareness from edge to enterprise,” said Gautham Gnanajothi, global vice president of research at Frost & Sullivan.

Guided by a long-term growth strategy focused on metering infrastructure modernization, digitalization, and utility partnerships, Landis+Gyr has shown its ability to adapt and lead in a rapidly evolving landscape. The company’s strategic agility and sustained investment in grid intelligence and real-time data capabilities have enabled it to scale effectively across the globe.

Innovation remains central to Landis+Gyr’s approach. Its suite of solutions addresses the full spectrum of utility metering and grid modernization needs, offering flexibility, interoperability, and enhanced performance across electricity, gas, and water infrastructure. “We’re honored to be recognized by Frost & Sullivan for our continued leadership in AMI,” said Peter Mainz, CEO of Landis+Gyr. “This award reflects the dedication of our global team and our commitment to innovation at the grid edge, where real-time intelligence is transforming how energy is managed. We’re not standing still. Through ongoing investment in cutting-edge technologies and customer-centric solutions, we’re shaping a smarter, more resilient energy future.”

Landis+Gyr’s unwavering commitment to customer experience further strengthens its market position. By streamlining service delivery, enabling utilities with near real-time data through its managed services, and maintaining high levels of system reliability, the company continues to meet the evolving needs of its global customer base. Its partner-led delivery model and focus on localization have been key to delivering long-term value across diverse regulatory and market environments.

Frost & Sullivan commends Landis+Gyr for setting a high standard in competitive strategy, execution, and market responsiveness. The company’s vision, innovation pipeline, and customer-first culture are shaping the future of advanced metering infrastructure and driving tangible results at scale.

Each year, Frost & Sullivan recognizes a Company of the Year in various sectors to highlight those that demonstrate outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning. This recognition honors forward-thinking organizations that are reshaping their industries through innovation and growth excellence.

Frost & Sullivan Best Practices recognitions celebrate companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.

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Contact:

Ashley Shreve
E: ashley.weinkauf@frost.com 

About Landis+Gyr

Landis+Gyr is a leading global provider of integrated energy management solutions. We measure and analyze energy utilization to generate empowering analytics for smart grid and infrastructure management, enabling utilities and consumers to reduce energy consumption. 
Our innovative and proven portfolio of software, services and intelligent sensor technology is a key driver to decarbonize the grid. Having enabled 9 million tons of CO2 savings in FY 2024 through our product offerings, Landis+Gyr manages energy better – since 1896.
With sales of USD 1.7 billion in FY 2024, Landis+Gyr employs around 6,300 talented people across five continents. For more information, please visit our website: www.landisgyr.com

Contact:

Fabio Franceschi
E: fabio.franceschi@landisgyr.com