SHANGHAI, April 16, 2026 /PRNewswire/ — Mabwell (688062.SH), an innovation-driven biopharmaceutical company with a fully integrated industry chain, announced that the National Medical Products Administration (NMPA) has accepted the Investigational New Drug (IND) application for its innovative LILRB4/CD3 TCE bispecific antibody (R&D code: 6MW5311). The drug candidate is being developed for hematologic malignancies, specifically Acute Myeloid Leukemia (AML), Chronic Myelomonocytic Leukemia (CMML), and Multiple Myeloma (MM).

6MW5311 is the world’s first innovative LILRB4/CD3 TCE bispecific antibody for which a clinical trial application has been submitted. It possesses broad prospects for clinical development and significant market potential. The U.S. IND application is currently in the pre-IND phase, with plans to formally submit it to the FDA in the second quarter of 2026.

6MW5311 is developed based on the T Cell Engager (TCE) technology platform and features a “2+1” asymmetric molecular structure. It simultaneously targets LILRB4 and CD3, forming an immunological synapse by bridging tumor cells and T cells, thereby activating T cells to efficiently kill tumors.

The molecule incorporates a unique steric hindrance design. This structure significantly reduces the binding activity of the CD3 antibody to T cells in the absence of tumor cells. T cells are specifically activated only when tumor cells are present, which substantially enhances safety while improving anti-tumor efficacy.

In vitro studies have demonstrated that 6MW5311 exhibits potent cytotoxic activity across multiple tumor cell lines and patient-derived samples. In vivo pharmacodynamic studies have shown that 6MW5311 achieves significant tumor inhibition in both LILRB4-high and LILRB4-low expressing AML tumor models. Notably, it achieved complete tumor clearance in high-expression models. Furthermore, 6MW5311 demonstrated a favorable safety profile in cynomolgus monkey safety evaluation models.

As a key technological approach for directly mobilizing T cells to kill tumors, TCE has shown significant clinical value in various lymphoma indications, with multiple products successfully launched. However, current treatments for AML and CMML primarily remain primarily limited to chemotherapy, hematopoietic stem cell transplantation, and targeted therapies for specific mutations; no TCE products have been approved for these indications to date.

About Acute Myeloid Leukemia (AML)
AML is a group of clonal malignant disorders originating from myeloid stem cells, characterized by high heterogeneity and mortality. Globally, approximately 172.4 thousand new cases of AML were diagnosed in 2022, with the number projected to reach 221.4 thousand by 2035, representing a compound annual growth rate (CAGR) of 1.94%. In China, approximately 30.8 thousand new AML cases were diagnosed in 2022, accounting for approximately 17.9% of the global total. The number is expected to reach 36.7 thousand by 2035, representing approximately 16.6% of the global total, with a CAGR of 1.36%.

About Chronic Myelomonocytic Leukemia (CMML)
CMML is a clonal hematopoietic stem cell disorder that shares overlapping features with both myelodysplastic syndrome (MDS) and Myeloproliferative Neoplasm (MPN). It is characterized by significant monocytosis in peripheral blood and carries an inherent risk of transformation to AML (approximately 15-20% within 3-5 years). CMML is a rare disease with an annual incidence of approximately 3-4 per 100,000, and currently lacks effective treatment options.

About Multiple Myeloma (MM)
MM is a clonal plasma cell malignancy characterized by the uncontrolled proliferation of monoclonal plasma cells in the bone marrow. This leads to the overproduction of abnormal immunoglobulins and subsequent end-organ damage, manifested as hypercalcemia, renal impairment, anemia, and bone lesions (collectively known as CRAB features). Globally, MM accounts for approximately 1%-2% of all cancers and about 10% of hematologic malignancies. The median age at diagnosis is approximately 69 years, with higher incidence rates observed in males and individuals of African descent. Over the past two decades, patient survival rates have significantly improved thanks to the application of proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. However, MM remains largely incurable, and most patients experience multiple relapses during the course of the disease.

About Mabwell
Mabwell (688062.SH) is an innovation-driven biopharmaceutical company with capabilities spanning the entire pharmaceutical value chain. The company is committed to providing more effective and accessible therapies to meet global medical needs, with a focus on oncology and aging-related diseases. Mabwell’s mission is “Explore Life, Benefit Health” and its vision is “Innovation, from Ideas to Reality.” For more information, please visit www.mabwell.com/en.

Forward-Looking Statements

This press release contains forward-looking statements including, but not limited to, the potential safety, efficacy, regulatory review or approval and commercial success of our product candidates and those relating to the Company’s product development, clinical studies, clinical and regulatory milestones and timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. “Forward-looking statements” are statements that are not historical facts and involve a number of risks and uncertainties, which may cause actual results to be materially different from any future results expressed or implied in the forward-looking statements. These statements may be identified by the use of forward-looking expressions, including, but not limited to, “expect,” “anticipate,” “intend,” “plan,” “believe,” “estimate,” “potential,” “predict,” “project,” “should,” “would,” and similar expressions and the negatives of those terms.

Forward-looking statements are based on the Company’s current expectations and assumptions. Forward-looking statements are subject to a number of risks, uncertainties, and other factors, many of which are beyond the Company’s control, including, but not limited to: environment; politic; economy; society; legislation; our dependence on our product candidates, most of which are still in preclinical or various stages of clinical development; our reliance on third-party vendors, such as contract research organizations and contract manufacturing organizations; the uncertainties inherent in clinical testing; our ability to complete required clinical trials for our product candidates and obtain approval from regulatory authorities for our product candidates; our ability to protect our intellectual property; the loss of any executive officers or key personnel. In case one or more of these risks or uncertainties deteriorate, or any assumptions are incorrect, the actual results may be seriously inconsistent with the stated results.

The Company cautions all the persons not to place undue reliance on any such forward-looking statements, which speaks only as of the date of this press release. The Company disclaims any obligation, except as specifically required by law and the rules of the applicable Stock authority to publicly update or revise any such statements to reflect any change in expectations or in events, conditions, or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. All forward-looking descriptions, figures and assumptions in this press release are applicable to this statement.

Advancing Energy Cooperation and Shared Development

BEIJING, April 16, 2026 /PRNewswire/ — A report from China Huadian Corporation Ltd:

China Huadian Corporation Ltd. (China Huadian) has continued to deepen its presence in Vietnam’s energy sector, contributing to stable electricity supply and supporting local socio-economic development.

At the core of its operations is the Vinh Tan II 2×660MW coal-fired power plant in Vietnam’s southern Tra Vinh province, invested in and operated by China Huadian. As a key project under Belt and Road cooperation, the plant has generated a cumulative 25.4 billion kWh of electricity since it began operation in 2021, accounting for approximately 33% of the province’s total power generation. Through efficient and stable operations, China Huadian has helped ease regional power shortages, ensured reliable electricity supply for households and businesses, and supported local industrial and commercial growth.

Beyond project operations, China Huadian continues to strengthen long-term cooperation in Vietnam by expanding engagement with government agencies, universities, and energy enterprises. The company actively participates in industry networks, including Chinese business organizations in Vietnam, and promotes collaboration between industry and academia to enhance knowledge exchange and technical cooperation. Looking ahead, China Huadian remains committed to increasing investment in Vietnam and supporting the country’s transition toward a greener and lower-carbon energy structure.

China Huadian also places strong emphasis on local talent development. Through youth exchange programs, study visits, power industry outreach activities, vocational training, and internship opportunities, the company is helping cultivate local expertise and build platforms for sustained people-to-people exchange between China and Vietnam.

With a long-term commitment to sustainable development, China Huadian will continue to invest in Vietnam’s energy sector, contribute to energy security, and support shared growth under a greener and more resilient future.

CAIRO, April 16, 2026 /PRNewswire/ — A report from Shandian News.

In an effort to advance the Global Civilization Initiative, Shandong Radio and Television Station held the unveiling ceremony of the “Oriental Screening Room” in Egypt, along with the presentation of the international version of Shining Treasures of China, in Cairo on April 14 local time.

The “Oriental Screening Room” serves as an international cultural exchange base established overseas by Shandong Radio and Television Station. By screening high-quality documentaries, short videos and other audiovisual content, it engages in “film and television diplomacy” to foster cultural exchange between nations. The initiative has already been launched in Greece, Uzbekistan, Australia and other countries, becoming an important window for local people to get a sense of China and learn about Shandong.

Shining Treasures of China was jointly produced under the guidance of the National Radio and Television Administration and the National Cultural Heritage Administration, in collaboration with 31 provincial-level radio and television stations and cultural heritage institutions, including Shandong Radio and Television Station. The Arabic version presented at the ceremony was translated by the Shandong International Communication Center.

Emad Zabady, Secretary General of the Egypt-China Cultural Exchange Association, said in an interview with a reporter from Shandong International Communication Center that he has visited Shandong five times and was deeply impressed by its profound historical heritage and vibrant development momentum. He expressed hope for deepening exchanges and pragmatic cooperation between the two sides in areas such as film and television media, cultural tourism and youth education, jointly promoting mutual learning between the Chinese and Egyptian civilizations and people-to-people bonds.

SINGAPORE, April 15, 2026 /PRNewswire/ — Motul continues to advance performance with sustainability, innovating solutions that take on a more holistic approach to hybrid vehicles, enhancing both lubrication efficiency and fuel system performance.

Renowned for its cutting-edge technology, exceptional performance and high-quality lubricants, Motul has launched its NGEN range – the next-generation lubricants to support modern hybrid engines while reducing environmental impact.

Carlo Savoca, Chief Marketing Officer of Motul Asia Pacific, said, “Motul is committed to innovating essential fluids that evolve with time. With the introduction of our latest NGEN Hybrid 0W-8 and E-Fuel System, we will continue to expand our product portfolio to meet the ongoing market requirement for hybrid vehicles.”

Keith Schulz, Chief Sustainability Officer of Motul Asia Pacific, said, “Motul’s commitment today is to address key societal challenges of our time. Supporting the next generation by innovating essential fluids that speak sustainability and performance is the way forward at Motul.”

A Growing Ecosystem for Hybrid Drivers

At the core of the hybrid portfolio, advanced formulations such as the NGEN Hybrid 0W-16, 0W-20, NGEN MATIC ATF VI and E DOT 5.1 are delivered to target protection across key areas of vehicle maintenance. Introducing the latest two additions to the hybrid portfolio, NGEN Hybrid 0W-8 and E-Fuel System Care.

NGEN Hybrid 0W-8

The NGEN Hybrid 0W-8 is an ultra-low viscosity engine oil developed for modern hybrid engines that:

• Promotes fuel efficiency and performance
• Improves oil flow at start up and stop/start events
• Minimising greenhouse gas emissions

Formulated with re-refined base oil and packaged with recyclable materials.

The new NGEN Hybrid 0W-8 viscosity is currently available in Japan.

E-Fuel System Care

The E–Fuel System Care addresses the unique challenges of engines that run intermittently and where fuel can remain in the tank for longer periods despite varying stop/start mode. Regular use helps to:

• Optimise fuel quality
• Protects fuel system from oxidation and deposits
• Enhance engine performance, cleans injectors for better combustion, improve fuel consumption and emissions
• Greater durability and driving comfort

E–Fuel System Care helps complement Motul’s NGEN hybrid engine oils, delivering a more complete solution for hybrid vehicles’ performance and protection.

The new E-Fuel System Care will be available starting June 2026.

Independent Study Highlights Hybrid Performance Gains

An independent study conducted by the Centre for Environmental Sustainability at Ngee Ann Polytechnic, Singapore has evaluated the performance of hybrid engine oils under real-world driving conditions.

The 77-day field study found that lower-viscosity engine oils can contribute to improved fuel efficiency, with observed savings of up to 109 litres per 10,000 km. Beyond efficiency, the findings also showed that advanced hybrid-specification formulations are capable of maintaining effective engine protection and wear levels when compared to higher viscosity oils. By reducing internal friction and supporting cleaner combustion, these oils help minimise engine wear, limit deposit formation, and contribute to lower fuel consumption and emissions over time. Over a typical vehicle lifespan, this could translate into meaningful cost savings for drivers, alongside improved long-term engine health and environmental performance.

These insights have shown Motul’s continued development of NGEN solutions is committed to helping drivers optimise performance, durability and sustainability in hybrid vehicles.

For more information and updates, please visit Motul Asia Pacific’s official website at https://www.motul.com/en-SG.

For more information and updates, please visit Ngee Ann Polytechnic’s Centre for Environmental Sustainability.

–END–

*Editor’s Note:

• The full study conducted by the Centre for Environmental Sustainability at Ngee Ann Polytechnic is available at: https://bit.ly/4my7CJ9
• Hi-res images are available at: https://bit.ly/4ccnRrB

ABOUT MOTUL

Founded in 1853, Motul is a world-class French company with a global footprint, specialising in high-tech engine lubricants and fluids for two-wheelers, cars, heavy-duty vehicles, marine and industrial applications via its brands Motul Tech and Baraldi. Renowned for its product quality and innovation, Motul introduced the world’s first fully synthetic four-stroke lubricant – the Motul 300V, in 1971. Over the years, Motul has become a trusted supplier to numerous motorsport teams and Original Equipment Manufacturers, maintaining its status as a key partner in prestigious international racing competitions such as the Dakar Rally, 24 Hours of Le Mans, and MotoGP.

In 2000, Motul established its Asia Pacific headquarters in Singapore, cementing its commitment to provide top-notch products in the region. Today, Motul’s presence spans across Asia Pacific, Middle East and South Africa with a focus on lubricant technology, meticulously tailored to the region’s diverse climate and driving conditions. With three research and development centres in Japan, Vietnam and India, a major manufacturing facility in Vietnam, and additional manufacturing partners in China, Japan, India, Thailand, Indonesia, Turkey and South Africa; Motul delivers cutting-edge solutions tailored to the unique needs of the dynamic Asia Pacific market.

Motul’s comprehensive and versatile product range includes solutions for everyday use, ensuring optimal performance, reliability, and meeting every need on the road. By continually investing in Research and Development, Motul is your trusted partner wherever you go, delivering superior performance and dependability for all driving conditions.

For more information, visit www.motul.com.

Kai Minejima-Lee, 17, defends his World Cup of Indoor Skydiving freestyle title

SINGAPORE, April 16, 2026 /PRNewswire/ — On 4 April 2026, at iFLY Aix-Marseille in the south of France, Kai Minejima-Lee defended his Solo Freestyle Open title at the 6th FAI World Cup of Indoor Skydiving. It was his 17th birthday — and exactly ten years since he first flew. Kai is represented by APRW, his appointed integrated communications agency.

Results

Kai claimed gold in the Solo Freestyle Open, defending the title he first won in Macau in 2024. He is the first athlete in the competition’s history to have done so. He also took bronze in Solo Speed and was part of Singapore’s gold-medal 4-Way Dynamic team alongside Kyra Poh, Vera Poh, and Choo Yi Xuan.

In total, Kai contributed three of Singapore’s six medals at the competition.

His technical score in the Solo Freestyle final was 9.5 out of 10. Toms Ivans of Latvia, a former coach, scored 9.3.

Singapore finished with six medals across four athletes — two gold, three silver, one bronze — above France and Germany in the overall medal tally.

The Story

The results aside, the day carried a detail worth noting.

On 4 April 2016 — his seventh birthday — Kai took his first flight at what was then iFLY Singapore. He had been watching Kyra Poh’s competition videos since he was four years old. Too young to fly (the minimum age in Singapore is seven), he had spent three years waiting. That birthday, he finally stepped into the tunnel.

Kyra was there.

On 4 April 2026, Kai stood on the podium at Aix-Marseille with Kyra Poh beside him. She had come second. It was the first time Singapore had occupied both top positions in an open freestyle event at World Cup level.

“Exactly ten years ago I took my first flight on my 7th birthday with Kyra, and now ten years later I am proud to be standing on the podium next to my friend, mentor and teammate. To represent Singapore and win my second open freestyle title alongside Kyra is special, and I’m so grateful for the decade of friendship, love and support from my team and family.”

— Kai Minejima-Lee

About Kai

Kai has competed internationally since the age of seven, accumulating over 50 medals across nine years, including 28 gold. He has reached the podium at his last 17 competitions.

He is the 2025 Singapore Sports Boy of the Year and a spexScholarship recipient.

Kai is currently pursuing an IB diploma at Eastwood Global Online School. Before that, he was homeschooled — and in between competitions, completed a course in Multivariable Calculus at the Johns Hopkins Center for Talented Youth. At ten years old, he delivered his first TEDx talk. He holds a junior black belt (3rd poom) in Taekwondo and also practises Wushu.

Background

Kai first won the Solo Freestyle Open title at the 5th FAI World Cup of Indoor Skydiving in Macau in 2024, where he was 15 and competing in the open category for the first time.

“There was so much hard work put into that,” he said after his first win in Macau in 2024, where he competed in the open category for the first time. In France this year, competing as the defending champion, he finished with a technical score of 9.5.

Kai Minejima-Lee’s Results at WCIS 2026

Overall National Medal Tally