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RESPONSIBLE LEADERSHIP UNDER THE SPOTLIGHT WITH LAUNCH OF IMPACT INDEX TO HOLD BUSINESS ACCOUNTABLE

Bambuddha Group White Paper and Impact Index Insights Set the Agenda for ‘The Future of Work 2035 with Responsible Leadership’

SYDNEY, Feb. 24, 2025 /PRNewswire/ — ‘Responsible Leadership 2035’ is on the agenda at the Bambuddha Group’s Round Table with the launch of a White Paper that shines the spotlight on leadership responsibility to reimagine the future of work through flexibility, collaboration and ESG-driven leadership as calls for return to work face ongoing headwinds.

‘The Future of Work 2035 – Responsible Leadership Imperatives to Drive Growth’ White Paper sets a clear vision for workplace practice in 2035, leaving no doubt that a new era in corporate leadership is no longer a nice-to-have, but critical for the survival of business, no matter the size.

“As Australia grapples with complex challenges, the role of CEOs as responsible leaders has never been more crucial,” says Anna Sheppard, Founder and CEO of Bambuddha Group, the social enterprise that offers game-changing leadership coaching to achieve equality, fairness and kindness in workplaces across the globe. Sheppard is the author of the Responsible Leadership 2035 White Paper, published in December 2024.

Grounded by insights from the Impact Index, The Future of Work 2035 – Responsible Leadership Imperatives to Drive Growth’ roundtable explores the transformative power of leadership grounded in ESG principles. The event will see CEOs from three diverse industries across Diagnostics, Technology, and Entertainment to explore the future of Responsible Leadership and identify key focus areas for the next decade, with an emphasis on reimagining the future of work (WFH, flexibility, and collaboration), prioritising ESG and societal impact as core business strategies and understanding DEI in the now and how this becomes embedded into a long-term strategy.

ABOUT BAMBUDDHA GROUP

Bambuddha Group is an award-winning advisory and training firm, dedicated to catalysing a global shift towards responsible leadership and sustainable practices by fostering a culture of compassion, empowerment, and kindness within organisations worldwide.

By 2035, our vision is to see a world where every decision-maker leads for humanity, where organisations thrive sustainably, and where success is measured not only by financial gains but also by positive impacts on society and the environment.

Programs provide access to literacy training, industry-leading coaches, executive education, and many resources to embed sustainable change and inclusive practices for people, customers, the community, and the environment.

Bambuddha Group has won multiple awards for work in this space, including being recognised as one of the” Top 10 Leadership Development Training and Coaching Companies 2021 in APAC”, Top 50 leading light for APAC, Top 50 most impactful LinkedIn Influencers, Finalists for Telstra Best of Business Awards for Accelerating Women and now join the world stage as thought leader of the year at the Women who change the world awards in London in early April.

ABOUT BAMBUDDHA IMPACT INDEX

The Bambuddha Impact Index is grounded in transformational leadership theory, systems theory, positive psychology, corporate social responsibility (CSR), sustainable development, and social justice. It integrates inclusive leadership and community engagement models emphasising empowerment, accountability, and holistic, long-term strategies for social, environmental, and organisational change.

The framework elucidates the intricate relationship between ESG practices and profitability, fostering a deep understanding of how responsible actions drive financial outcomes. It ensures decision-makers understand the importance of sustainability initiatives by highlighting tangible outcomes, opportunities and their competitive advantage in order to guide leaders toward success.

ABOUT ANNA SHEPPARD

Anna Sheppard is a Stevie award-winning inspirational speaker and emcee and the founder and CEO of Bambuddha Group. Anna spends much of their time working as an inspirational speaker, producer, and consultant with organisations and leaders who want to understand the benefits of social responsibility through a world-leading Kindness methodology.

BAMBUDDHA ON SOCIAL

 

Bybit Defies Odds: How the Largest Crypto Hack in History Became a Test of Resilience and Transparency

DUBAI, UAE, Feb. 23, 2025 /PRNewswire/ — In a remarkable display of resilience and professionalism, Bybit, the world’s second-largest cryptocurrency exchange by trading volume, has successfully navigated the largest hack in crypto history. On February 21, 2025, hackers stole approximately $1.5 billion in digital assets from Bybit’s Ethereum wallet, marking the biggest cryptocurrency heist ever recorded. Despite this unprecedented breach, Bybit’s swift and transparent crisis management ensured that the crypto market remained stable, with no significant price volatility.

Swift Crisis Management

Bybit’s response to the hack was marked by swift action, transparency, and professionalism.  Ben took immediate ownership of the situation, addressing the community within 30 minutes via X and conducting a livestream session just one hour after the incident. This live session, which lasted over two hours, provided real-time updates and detailed explanations, ensuring that all stakeholders were informed and reassured. Bybit’s prompt and open communication effectively prevented panic and maintained trust in the exchange, setting a high standard for crisis management in the crypto industry

Throughout the crisis, Bybit’s withdrawal and product services remained uninterrupted, with clients able to access support and their respective relationship managers at all times. This seamless continuity was a testament to the team’s preparedness and efficiency, even under extreme pressure.

Industry Unity in Support of Bybit

The crypto industry rallied around Bybit, demonstrating a united front against security threats. Major exchanges blacklisted the hacker’s wallets, preventing further movement of stolen funds. This unprecedented show of unity underscores the growing maturity of the crypto sector, where competitors become allies in times of need.

Client Fund Protection

Despite the significant scale of the hack, Bybit’s 1:1 reserve guarantee ensured that client assets remained fully intact. Bybit CEO Ben Zhou reassured users that Bybit is solvent and can cover the loss, emphasizing that all client assets are backed on a one-to-one basis. This guarantee demonstrates Bybit’s financial stability and commitment to user security.

Regulatory and Law Enforcement Collaboration

Bybit worked closely with regulators and law enforcement agencies to address the hack. This collaboration not only facilitated a swift response but also set a precedent for future cooperation between the crypto industry and regulatory bodies. As the incident unfolds, further developments are expected from this front, potentially leading to enhanced security measures and regulatory frameworks.

Rapid Recovery

Bybit demonstrated remarkable resilience in the face of the crisis, processing over 350,000 withdrawal requests efficiently within 12 hours of the hack. Despite the surge in withdrawal requests, the exchange ensured that all transactions were completed without significant delays, showcasing the team’s professionalism and experience in managing critical incidents. Bybit’s operations quickly returned to normal, with client activity rebounding to pre-hack levels within 24 hours. This swift recovery underscores the trust that clients and investors have in Bybit’s crisis management capabilities, highlighting the exchange’s ability to maintain stability even in the most challenging circumstances

Bybit’s handling of the recent hack sets a new industry standard for crisis management. The exchange’s ability to turn a potentially disastrous event into a demonstration of resilience and transparency is a testament to its long-standing culture of responsibility and openness. This incident highlights not just Bybit’s operational excellence but also the growing maturity and unity of the crypto industry as a whole.

#Bybit / #TheCryptoArk

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving a global community of over 60 million users. Founded in 2018, Bybit is redefining openness in the decentralized world by creating a simpler, open and equal ecosystem for everyone. With a strong focus on Web3, Bybit partners strategically with leading blockchain protocols to provide robust infrastructure and drive on-chain innovation. Renowned for its secure custody, diverse marketplaces, intuitive user experience, and advanced blockchain tools, Bybit bridges the gap between TradFi and DeFi, empowering builders, creators, and enthusiasts to unlock the full potential of Web3. Discover the future of decentralized finance at Bybit.com.

For more details about Bybit, please visit Bybit Press 

For media inquiries, please contact: media@bybit.com

For updates, please follow: Bybit’s Communities and Social Media

Discord | Facebook | Instagram | LinkedIn | Reddit | Telegram | TikTok | X | Youtube

HTX Global Advisor Justin Sun Advocates Crypto Security Collaboration

SINGAPORE, Feb. 23, 2025 /PRNewswire/ — In the wake of the recent $1.5 billion hack affecting a major cryptocurrency exchange, HTX hosted a live discussion on X and its Global Advisor Justin Sun addressed the growing security concerns in the cryptocurrency industry. The discussion, titled “Together Against Industry Crisis, Is There a Best Solution for the Security of the Crypto Industry?” featured insights from leading security firms SlowMist and GoPlus Security, as well as prominent KOLs.

Security: A Top Priority for HTX

Sun stressed that security is a “top priority”, demanding constant vigilance and learning. He illustrated how hacker tactics have evolved, from early hot wallet attacks to more sophisticated multi-signature wallet breaches, and declared that exchanges must continuously enhance their security protocol.

Sun emphasized that security is like personal health management, requiring internal efforts and a proactive approach. HTX has implemented multi-device login, remote login alerts, abnormal transfer alerts, and other security features, and has publicly disclosed Merkle Tree Proof of Reserve (PoR) for 28 consecutive months, maintaining reserve ratios exceeding 100%.

Sun’s Influence on Security Practices Across the Crypto Landscape

Sun’s commitment to security extends to his vision for HTX and his influential role in shaping security practices across the broader crypto landscape. He believes that the principle of security is considered fundamental to every business and product. He cited the early implementation of native multi-signature functionality in TRON as a successful example of proactive security design, demonstrating his commitment to building security into the foundation of his projects. He also highlighted the recent launch of USDD 2.0, emphasizing the deep understanding of stablecoin security risks that informed its development. “Just as exchanges should strengthen security mechanisms from the source in system design and operation, to maximize the prevention of security incidents,” Sun stated.

Sun also revealed that HTX collaborates with numerous white hat teams to conduct continuous penetration testing, security drills, and vulnerability mining. The platform actively monitors global cryptocurrency security incidents and studies hacker attack principles and methods for effective prevention.

Addressing the Situation and Industry Cooperation

Regarding the controversy surrounding CZ’s suggestion for the affected exchange to suspend withdrawals, Sun acknowledged the validity of the advice from an exchange perspective. He explained that the initial hours after a security breach are crucial for investigating the issue and ensuring safety. While suspending withdrawals is necessary to eliminate risks, the suspension period should be minimized to reduce user impact.

Sun called for closer cooperation between exchanges, security agencies, and the community to jointly address hacker threats, promote technological sharing, security innovation, and information exchange, and promote the healthy and sustainable development of the industry.

HTX’s Commitment to User Safety

HTX demonstrates its commitment to security through a proactive and continuously improving approach. The platform’s multi-faceted security strategy encompasses collaboration with leading security experts, rigorous ongoing monitoring, robust internal protocols, and a focus on enhancing multi-signature support, security alerts, and mitigating emerging threats such as hashtag scams. This comprehensive strategy reflects HTX’s dedication to safeguarding user assets and fostering a secure and reliable trading environment. This commitment was further emphasized by the specific security protocol requirements shared by Justin Sun at the February 21st Meetup in Hong Kong.

About HTX

Founded in 2013, HTX has evolved from a virtual asset exchange into a comprehensive ecosystem of blockchain businesses that span digital asset trading, financial derivatives, research, investments, incubation, and other businesses.

As a world-leading gateway to Web3, we harbor global capabilities that enable us to provide users with safe and reliable services. Our growth strategy – “Global Expansion, Thriving Ecosystem, Wealth Effect, Security & Compliance”, underpins our commitment to providing quality services and values to virtual asset enthusiasts worldwide.

For more information on HTX, please visit the HTX Square, or https://www.htx.com/, and follow X, Telegram, Discord. For further press enquiries, please contact glo-media@htx-inc.com

Contact Details
Ruder Finn Asia  
htx@ruderfinn.com 

Be My Guest: The Bridge Episode

GUIYANG, China, Feb. 23, 2025 /PRNewswire/ — Guizhou, the only province in China without plains, is home to over 30,000 completed and under-construction bridges. Nearly half of the world’s top 100 high bridges are located here. The people of Guizhou have carved roads through mountains and built bridges over rivers, creating a vast high-speed transportation network. Tens of thousands of bridges connect Guizhou to the rest of the country and the world, allowing local products to reach markets far and wide.


Be My Guest: The Bridge Episode

The short video series “Be My Guest• Focus Guizhou“, produced by Guizhou Satellite TV and the International Communication Center of Guizhou Radio and Television Station, adopts a reality show format with international photographers invited to explore Guizhou. Through their lenses, the series captures their authentic experiences and the richness of Guizhou’s culture.

In this episode, Norwegian travel photographer Ole Eidskrem, who dreams of being a bridge between China and Western countries, accepts an invitation from travel vlogger Fang Jiayu from Hong Kong to explore Guizhou known as the world’s canyon and bridge museum. 

Their journey begins at the Longli River Bridge, where local travel vlogger Yuan Wenwen guides them. Together, they take in breathtaking views of the canyon below and tackle the adrenaline-pumping challenge of bungee jumping from the bridge.

They then visit the Hongfeng Lake, where they sail to the center to admire the Huayu Cave Bridge, a basket-shaped bridge. They learn how the bridge earned itself the Gustavus Lindsahl Award, the world’s most prestigious bridge construction award. From a distance, they spot bird nests built atop the bridge, a testament to Guizhou’s commitment to ecological preservation and the harmony with nature.

Along the lakeshore, they enjoy a local delicacy, thorn pear, and discover how bridges have played a crucial role in bringing Guizhou’s specialties to the world.

The journey concludes at the under-construction Huajiang Canyon Bridge, soon to be the world’s tallest. On the catwalk of the bridge, Liu Hao, the chief engineer, shares the significance of this monumental project and its promise to enable a breathtaking “37-second crossing” of the canyon.

“Standing there, I felt like we were connecting cultures, technologies, and ideas,” Ole says. This bridge-themed journey gives him a deeper understanding of the critical role bridges play in Guizhou and solidify his commitment to building a bridge of friendship between China and Norway. 

YouTube Link:https://youtu.be/PclTXlgP7ZA

Review and Outlook of Sanyou Bio Intelligent Super-trillion Molecule Discovery Platform

SHANGHAI, Feb. 23, 2025 /PRNewswire/ — On February 15, 2025, Sanyou Bio conducted a full review of its Intelligent Super-trillion Molecule Discovery Platform. As the core technology of the platform, the intelligent super-trillion molecule library boasts a library capacity of up to 10 trillion, enabling the screening and identification of hundreds to thousands of lead molecules for a single target. By integrating high-through eukaryotic expression verification and multidimensional druggability analysis, the platform significantly improves the efficiency of innovative biological drug R&D and plays a key role in novel macromolecule drug discovery.

Sanyou Bio’s Intelligent Super-trillion Molecule Discovery Platform consists of ten sub-platforms, encompassing a variety of molecular types. These include super-trillion fully human antibody discovery platform, super-trillion common light chain antibody discovery platform, super-trillion 2C type single-domain antibody discovery platform, super-trillion 4C type single-domain antibody discovery platform, super-trillion cyclic peptide discovery platform, super-trillion novel targeting protein discovery platform, magnetic-array mouse immune antibody discovery platform, magnetic-array alpaca immune antibody discovery platform, magnetic-array rabbit immune antibody discovery platform, and magnetic-array canine immune antibody discovery platform.

Details of the ten sub-platforms are summarized in Table 1. Each sub-platform has unique characteristics and can be widely applied in therapeutic, diagnostic, detection and scientific research fields. So far, the Intelligent Super-trillion Molecule Discovery Platform has completed over 650 molecule discovery projects, advancing more than 100 PCC projects, with several projects have entered the clinical stage. This further demonstrates the capability of Sanyou Bio’s platform to complete the development of mainstream drug molecules such as monoclonal antibody drugs, bispecific antibody drugs, multi-specific antibody drugs, ADC drugs, AOC drugs, RDC drugs, PDC drugs, and CAR-T immune cell therapy.

Table 1. Applications and Advantages of the Intelligent Super-trillion Molecule Discovery Platform

No

Library

Library
Capacity

CDR3
length

Characteristics

1

Super-trillion fully
human antibody
discovery platform

2.16 x 1012

5~28

Direct acquisition of fully human antibody sequences with
high antibody diversity; capable of obtaining hundreds of
lead molecules

2

Super-trillion
common light chain
antibody discovery
platform

1.12 x 1012

4~26

Common light chain with excellent druggability and high
heavy chain diversity; capable of obtaining hundreds of
lead molecules

3

Super-trillion 2C
type single-domain
antibody discovery
platform

2.13 x 1012

12~19

Humanization level up to 98%, enabling the discovery of
antibody drugs for high-difficulty targets

4

Super-trillion 4C
type single-domain
antibody discovery
platform

1.94 x 1012

14~21

Humanization level up to 98%, with excellent molecule
stability and resistance to degradation; antibody affinity
reaching pM level

5

Super-trillion cyclic
peptide discovery
platform

3.05 x 1012

4~17

High diversity; optimized fusion with tag proteins for
natural peptides, enabling eukaryotic expression,
purification, and mass production

6

Magnetic-array
mouse immune
antibody discovery
platform

7.10 x 1011

4~15

Fast screening speed, the process is nearly three months
shorter compared to hybridoma screening technology;
antibody affinity reaching pM level

7

Magnetic-array
alpaca immune
antibody discovery
platform

2.83 x 1011

3~27

Capable of obtaining a large number of antibody
molecules for high-difficulty targets, covering most of the
protein epitopes

8

Magnetic-array
rabbit immune
antibody discovery
platform

4.88 x 1010

6~20

Abundant types of immune raw materials and diverse
screening methods;easy to obtain high-specificity, high-
affinity antibodies

9

Magnetic-array
canine immune
antibody discovery
platform

4.21 x 109

5~20

Direct acquisition of canine-derived monoclonal
antibodies, no need for caninization; filling the gap in pet
monoclonal antibody market

10

Super-trillion novel
targeting protein
discovery platform

6.00 x 1010

4~8

Stable protein backbone structure with low
immunogenicity; variable regions avoid modification
sites, and molecules obtained have high druggability

Part 1 Review of the Intelligent Super-trillion Molecule Discovery Platform

1. Super-trillion fully human antibody discovery platform

Library background and history

Phage display technology is a crucial way to develop fully human antibodies, demonstrating advantages over hybridoma antibody technology in many aspects. Currently, human phage display antibody libraries on the market face challenges such as limited donor sources, low library capacity, low diversity, low affinity, and low druggability. To address these issues and obtain more candidate antibodies with better quality, Sanyou completed the conceptual design of the sub-trillion fully human antibody library in 2017, focusing on antibody backbone sequences with higher druggability and avoiding the presence of pseudogenes at the same time. By 2018, the sub-trillion fully human antibody library was constructed and validated. To further expand the library capacity, Sanyou completed the conceptual design of the super-trillion fully human antibody library and the super-trillion fully human semi-synthetic antibody library in 2019 and 2020 respectively. By 2021, both antibody libraries were constructed and validated.

Library composition and characteristics

Sanyou’s super-trillion fully human antibody discovery platform consists of two major libraries: super-trillion fully human antibody library and super-trillion fully human semi-synthetic antibody library, with a total library capacity of 2.16 trillion. The super-trillion fully human antibody library is a recombinant antibody library after gene cloning of human B cells. It is derived from nature with excellent druggability and the median number of lead molecules obtained is 300+. The super-trillion fully human semi-synthetic antibody library is derived from human B cells after gene rearrangement with engineering design. It offers high diversity with a median number of lead molecules obtained also at 300+.

Library cases and applications

So far, Sanyou has completed over 200 single-target screenings using fully human antibody library. The lead molecules obtained from super-trillion fully human antibody library can reach hundreds. As shown in Figure 1, through screening and validation across 11 different targets, a total of 5,069 fully human antibody clones with unique sequences were obtained, and the median number of clones was 345 per target. The affinity of molecules screened from Sanyou’s super-trillion fully human antibody library often ranges from sub-nM to nM levels. Figure 2 shows the affinity analysis of expressed supernatant samples. The results reveal that the majority of antibody clones exhibit affinities in the 10⁻⁸ to 10⁻¹⁰ range.

2. Super-trillion common light chain antibody discovery platform

Library background and history

Bispecific antibodies with a common light chain configuration can effectively solve the issue of light-heavy chain mismatch, and are highly consistent with natural IgG-type antibodies in structure. Compared with various non-human bispecific antibody configurations, bispecific antibodies with a common light chain configuration offers better druggability and safety profiles in human body. Sanyou completed the preliminary conceptual design of the common light chain antibody library, and conducted preliminary research on common light chain antibodies in 2017. Then completed the construction of the billion-level common light chain antibody library in 2018, and the validation of the billion-level common light chain antibody library in 2019. In 2020, the concept design of the super-trillion common light chain antibody library was completed, and 2 exceptional light chains were selected from over 1800 light chains through rigorous screening. The construction and validation of the super-trillion common light chain antibody library was completed in 2022.

Library composition and characteristics

Sanyou’s super-trillion common light chain antibody discovery platform is composed of 2 light chains and 6 sub-libraries with a total library capacity of 1.12 trillion. It is a recombinant antibody library by selecting 2 exceptional light chains paired with a diverse set of heavy chains. The library is derived from fully human natural antibodies, with carefully selected light chains for optimal performance and diverse heavy chains. The median number of lead molecules obtained is 300+. Common light chain antibodies targeting different epitopes of the same target or different targets can be screened in one step; the obtained common light chain antibodies are fully human antibodies and can be directly used for downstream bispecific antibody development.

Library cases and applications

So far, Sanyou has completed over 30 screenings using common light chain antibody library. For different targets, an average of hundreds of lead antibody molecules with unique sequences and good affinity can be obtained. As shown in Figure 3, through screening and validation across 7 different targets, a total of 4,942 common light chain antibody clones with unique sequences were obtained, and the average number of unique sequence clones was 706 per target. The binding activity of candidate antibodies obtained from the human library (hRAL) and the common light library (CLC) was detected by ELISA. Figure 4 reveals that the proportion of hRAL candidate antibodies with EC50 between 0.01 and 0.1 was 94.44%, while the proportion of CLC candidate antibodies with EC50 between 0.001 and 0.01 was 78.95%, indicating CLC antibodies have higher affinity.

3. Super-trillion single-domain antibody discovery platform

Library background and history

Humanization of single-domain antibodies can significantly reduce the immunogenicity of camel-derived antibodies and accelerate the production and commercialization of antibody-based drugs. To overcome the defects of traditional single-domain antibody preparation technology, such as long preparation cycles, heavy screening workloads, and small number of lead candidates, Sanyou’s super-trillion single-domain antibody discovery platform has undergone four generations of library upgrades: completion of the construction and validation of the 10-billion single-domain naïve library in 2018; completion of the construction and validation of the sub-trillion single-domain antibody library in 2019; completion of the humanized single-domain conceptual design using a humanized backbone for library construction, and at the same time design of sub-libraries with only 1 pair of cysteines and 2 pairs of cysteines; completion of the construction and validation of the super-trillion humanized single-domain antibody library in 2021.

Library composition and characteristics

Sanyou’s super-trillion single-domain antibody library is constructed using internationally advanced primer synthesis technology and a humanized backbone with excellent druggability, ensuring superior therapeutic potential. This platform has independent intellectual property rights and is supported by comprehensive physicochemical and biomedical analyses for efficient screening. The platform comprises two major sub single-domain synthetic libraries 2C-type and 4C-type. There are further divided into 16 sub-libraries with a total library capacity of 4.07 trillion. The humanization degree of the antibody backbone reaches 98% and the median number of lead molecules obtained is over 600.

Library cases and applications

So far, Sanyou has completed over 60 screenings using single-domain antibody library. As shown in Figure 5, through screening and validation across 14 different targets, a total of 9,423 humanized single-domain antibody clones with unique sequences were obtained, and the median number of clones was 606 per target. The affinity of nanobody candidate molecules screened from Sanyou’s super-trillion humanized single-domain antibody library has excellent affinity and often reaches pM levels. Figure 6 shows the affinity analysis of full-length constructed molecules. The results reveal that the majority of antibody clones exhibit very high affinities.

4. Super-trillion cyclic peptide discovery platform

Library background and history

According to statistics, the global peptide drug market reached $62.8 billion in 2020 and is expected to grow to $96 billion by 2025, highlighting the significant growth potential in this sector. Peptide-based drugs offer the advantages of high specificity, low immunogenicity, less toxic side effects, and the applicability to intracellular targets. The establishment of peptide libraries is crucial for peptide drug R&D, but constructing such libraries requires substantial time and financial investment for most drug R&D companies. To address this challenge, Sanyou completed the construction and validation of the sub-trillion cyclic peptide library in 2022 and further advanced to the super-trillion cyclic peptide library in 2023, significantly enhancing the efficiency and success rate of peptide drug discovery.

Library composition and characteristics

Sanyou’s super-trillion cyclic peptide library follows natural design principles, supplemented by AI-driven design, fused with tag proteins, combined with phage display technology for high-throughput screening, and matched with comprehensive physicochemical and biochemical analyses for further validation. The library has a total of 19 sub-libraries, with peptide lengths ranging from 4 to 17 amino acids and a total library capacity of 3.05 trillion. The cyclic peptide platform integrates optimized tag protein with natural cyclic peptide and is suitable for PDC, oral, and intracellular target drug development, with a median number of lead molecules obtained of 60+.

Library cases and applications

So far, Sanyou has completed over 20 screenings and validation using cyclic peptide library. As illustrated in Figure 7, the peptide molecule A083, obtained from the super-trillion cyclic peptide library, underwent affinity maturation and was evaluated for ELISA binding activity using huPD-L1 antigen protein. The EC50 of antigen-binding was approximately 0.04 nM, comparable to the affinity of the reference antibody. Additionally, A083 demonstrated a 10-fold improvement in blocking activity, compared with the reference antibody. Figure 8 reveals that the EC50 for blocking the interaction between huPD1 and huPD-L1-CHO-K cells was 5.7 nM,

5. Magnetic-array immune antibody discovery platform

Library background and history

Sanyou Bio established its proprietary phage display vector platform in 2015, and applied the “multi-pathway antigen and antibody library” technology to the development of innovative antibody drugs. In 2016, we integrated hybridoma technology and phage display technology to promote the commercialization of the mouse immune antibody library. In 2017, the mouse immune library underwent a significant upgrade by incorporating array-based primers to further improve library diversity. The alpaca immune antibody library was launched in 2018, and afterwards, the rabbit immune antibody library and the canine immune antibody library were established in 2023 and 2024 respectively.

Library composition and characteristics

Sanyou’s magnetic-array immune antibody library includes: mouse immune antibody library, alpaca immune antibody library, rabbit immune antibody library and canine immune antibody library, with a total library capacity of 1.05 trillion. The specific parameters of each immune library are shown in Table 2. Antibodies can be produced for different target types (including small molecules). The number of nanoantibody lead molecules obtained through the screening of the Sanyou magnetic array immune antibody library is large, usually reaching dozens of molecules, with high molecular affinity. The library has broad target coverage, capable of screening antibodies against diverse targets, including small molecules and high yield of lead molecules, typically dozens per target with excellent affinity.

Table 2. Technical specification of the magnetic-array immune antibody library

No

Library

Library
capacity

Targets
completed

Characteristics

1

Magnetic-array
mouse immune
antibody discovery
platform

7.10  x 1011

263

1. Direct acquisition of antibody sequence to
accelerate the progress of project development

2. Multi-point and diverse immunization, easy to
obtain cross-species reactive antibody molecules

3. Capable of delivery of dozens to hundreds of
lead molecules

2

Magnetic-array
alpaca immune
antibody discovery
platform

2.83  x 1011

180

1. Defined antibody sequence to reduce
redundant screening workloads

2. Capable of delivery of dozens to hundreds of
lead molecules

3. Coverage on high-difficulty and hidden-
epitope targets

3

Magnetic-array
rabbit immune
antibody discovery
platform

4.88  x 1010

36

1. Single subtype, easy to humanize

2. Diverse immunization strategy, easy to obtain
antibodies with high affinity

3. Suitable for diagnostic antibody development

4

Magnetic-array
canine immune
antibody discovery
platform

4.21  x 109

10

1. Fill the gap in the pet monoclonal antibody
market

2. Simplify the technical difficulty of
caninization

3. Canine monoclonal antibodies have a longer
half-life

Library cases and applications

So far, Sanyou has completed over 480 screenings using immune antibody library. As illustrated in Figure 9, through screening and validation across 12 different targets, a total of 637 antibody clones with unique sequences were obtained, and the median number of clones was 55 per target. The affinity of antibody molecules screened from immune antibody library construction and screening service usually reaches pM levels. Figure 10 shows the affinity of the molecules screened from immune antibody library is comparable to or significantly better than that of the reference antibody.

Part 2 Development of the Intelligent Super-trillion Molecule Discovery Platform

1. Construction plan of the 100-trillion molecule library platform

Sanyou Bio remains committed to its mission of “making innovative biologics easier worldwide”. Building upon the foundation of the Intelligent Super-trillion Molecule Discovery Platform, we are now advancing the development of the 100-trillion Molecule Library Platform, driven by R&D and innovation to promote the development of the specialized services. Based on the current molecule library, the 100-trillion molecule library in future will achieve: 1) the library types will be expanded on top of the existing 10 sub-libraries to further diversify by incorporating nucleic acid libraries, small peptide libraries, and small molecule libraries. By 2027, the total library capacity is projected to reach 100 trillion; 2) the design of the library will be further optimized through AI assistance, the molecule diversity and performance will be further improved based on massive data analysis, and the customized construction of novel molecule library will be carried out; 3) through AI-driven drug screening, the screening efficiency will be accelerated, the R&D cycle will be shortened, and the success rate of new drug discovery will be enhanced.

2. Construction plan of the intelligent drug screening platform

The intelligent drug development platform aims to revolutionize antibody drug discovery through virtual screening and design optimization technology powered by generative AI models. This innovative approach will significantly improve drug development efficiency, and help solve the current issues of long antibody drug development cycle, high cost and low success rate. The intelligent drug development platform will greatly shorten the drug development cycle and enhance the success rate.

The intelligent drug screening platform plans to further develop AI-driven drug screening and other applications based on multiple applications such as the oneClick+ bispecific antibody design platform that have been launched. Main applications include: 1) De novo molecule generation, by utilizing AI algorithms to design and generate of molecular structures with specific properties and functionalities. Break through the traditional discovery model, enabling the design and development of first-in-class drugs, and expand the scope and possibilities of drug development; 2) Coding sequence optimization, through AI-powered sequence optimization to enhance the druggability and stability of the molecules; 3) Innovative molecule library design, based on AI-driven big data analysis to design and construct next-generation molecule libraries with improved efficiency and success rate of drug screening and discover more molecules with potential application value. This will further solve the drug development issues of high-difficulty targets such as GPCRs, ion channels, and intracellular proteins, and develop new drug delivery methods such as oral administration. The rapid development of these technologies enables us to discover drug targets with higher efficiency and shorter time, create biologics that meet clinical needs, and respond to diverse scientific and medical challenges.

3. Prospects of the development of the intelligent super-trillion molecule library

Traditional drug discovery often faces challenges such as long development cycles and high costs. In contrast, the intelligent super-trillion molecule library platform, powered by AI-driven technologies, accelerates the discovery and development process, reduces costs, and enhances efficiency.

Looking into the future, Sanyou Bio’s intelligent super-trillion platform will develop in a more intelligent direction. In terms of development direction, it explores towards 5 major directions, including indications, molecular formats, application scenarios, mini-programs, and important targets. In terms of molecular types, it covers 6 types of molecules, including fully human monoclonal antibodies, common light chain antibodies, humanized single-domain antibodies, cyclic peptide molecules, ADC molecules, and mRNA molecules, proving diversified molecular tools for the treatment of different diseases. In terms of application scenarios, it is adapted to 8 key scenarios, including ELISA, WB, IHC, IF, IP-ID, FC, SPA, and SPB. In terms of technology integration, 7 AI-driven programs are integrated, including de novo generation, epitope prediction, immunogenicity prediction, druggability prediction, specificity prediction, affinity predication, and one-click molecule design, to improve the intelligence level of R&D. In terms of disease research, it focuses on 9 major human diseases, including tumors, autoimmune, infection, metabolism, ophthalmology, neurology, cardiovascular, anti-aging, and various rare diseases. In terms of target exploration, it concentrates on in-depth research over 100K important targets by integrating 10 major technology platforms to lay a solid foundation for the development of more innovative drugs.

After 10 years of relentless effort and technological innovation, Sanyou Bio’s intelligent super-trillion molecule library platform has established a world-leading antibody drug discovery system. With the design of super-trillion molecule library and ten categories of molecule libraries, the platform has successfully solved the key difficulties in the discovery of innovative macromolecule drugs and has broad application prospects, especially in the fields of tumor treatment, infectious disease prevention and treatment, autoimmune diseases and rare diseases. The ability of high-efficiency screening, precise optimization and rapid evolution provides strong support for the development of global antibody drugs. In the next five years, the current library will continue to be upgraded to the 100-trillion molecule library. Combined with AI power and high-throughput screening technology, it will be able to predict the properties of drugs more accurately, thus significantly improving the efficiency and success rate of drug development. This will greatly expand our space for exploring potential drug molecules and accelerate the process of new drug discovery. Sanyou Bio will continue to promote in-depth collaboration with professional teams globally to jointly accelerate the process of drug R&D in high-difficulty disease areas and bring more breakthrough treatment options to patients worldwide.

About Sanyou Bio

Sanyou Biopharmaceuticals Co., Ltd. is a world-leading high-tech biotechnology enterprise focusing on R&D and services of innovative biologic drugs. Sanyou has built the 4C business patterns that integrate “differentiated CRO, integrated CDO, innovative CPO and characteristic CRS”, to accomplish the mission “to make the R&D easy for innovative biologics”.

Sanyou has established an integrated innovative biologic drug R&D laboratory with advanced facilities, and has a professional team with the majority holding a Ph.D. or master degree. Sanyou has built three industry-leading innovative technology platforms featured by “super-trillion, integration, and intelligence” , which are comprised of more than 50 sub-platforms with the core innovative super-trillion phage display platform, and supported by platforms of material preparation, biologics discovery, molecule optimization, in vitro and in vivo efficacy, production cell line construction, upstream and downstream process development, preclinical R&D, industrialization development, etc.

Sanyou’s business network has expanded to all parts of the world, including Asia, US and Europe, and established branches in Boston, Philadelphia, San Diego and London. Sanyou has established friendly business relationships with more than 1000 pharmaceutical companies, drug R&D institutions and diagnostics companies worldwide. Sanyou received National-level certification as a high-tech enterprise and a Specialized and Sophisticated enterprise, and passed the ISO9001 quality assurance certification and GB/T intellectual property management system certification.

Over 3.2 million likes! Witsbb’s Australia Traceability Livestream Witnesses Quality Commitment, Allergen-Free Nutrition Gains Global Attention

SYDNEY, Feb. 23, 2025 /PRNewswire/ — After travelling over ten hours by plane, Chinese well-known blogger @Guo Xiaopang Couple reached Sydney, Australia, and started Witsbb’s traceability livestream, revealing the secrets behind its “allergen-free” nutrition. They demonstrated the brand’s commitment to quality and transparency by livestreaming Witsbb’s research capabilities and production chain. Winning over 3.2 million likes, the livestream triggered a phenomenal topic discussion and successfully set off a trend of scientific calcium supplementation in spring.

Over 3.2 million likes! Witsbb’s Australia Traceability Livestream Witnesses Quality Commitment, Allergen-Free Nutrition Gains Global Attention
Over 3.2 million likes! Witsbb’s Australia Traceability Livestream Witnesses Quality Commitment, Allergen-Free Nutrition Gains Global Attention

Against the iconic Sydney Opera House, @Guo Xiaopang Couple presented Witsbb’s top products, including “allergen-free” DHA, Lysine Calcium Magnesium Zinc PLUS, and Liquid Calcium Soft Capsules. Consumers were highly engaged, leaving comments like “My child is also taking it” and “Trust Witsbb for allergen-free nutrition.” Many mothers said the livestream increased their confidence in Witsbb’s products.

During the traceability journey, the couple visited Witsbb’s factory and offline pharmacies in Australia, providing a comprehensive view of the production process, quality control, and sales situation. Dr. John, a nutrition expert, was also invited to answer consumers’ questions of their principal concern on-site. He highlighted that Witsbb has passed the dual certifications of Australia’s TGA and the US FDA, emphasizing the brand’s commitment to product quality. In Australia, Witsbb’s Vitamin AD and liquid calcium products have long been top sellers.

Spring is the golden season for children’s bone growth, but calcium supplementation for infants and young children with sensitive constitutions requires more professional solutions. Witsbb’s scientific formula and pure ingredients make it a top choice for many mothers.

Dr. John said, “This 10,000-kilometer traceability journey is an important milestone in our commitment to the ‘allergen-free formula’ philosophy. We will continue to invest in research on allergen-free nutrition, constantly upgrading and innovating our formulas so that they can be enjoyed by more sensitive babies with confidence.”

As the livestream concluded with the night sky over Sydney Harbour, Witsbb reaffirmed its dedication to safe feeding through solid scientific research. Driven by the dual trends of consumption upgrade and scientific parenting, professional nutrition brands like Witsbb are ushering in a new era of precise infant and child health management.

Aeroband is selected as the exclusive music instrument brand for the 56th NAACP Image Awards® Official Celebrity Gift Lounge, celebrating innovation, music, and culture

Unleash the Rhythm of Greatness: Empowering Musicians Everywhere

LOS ANGELES, Feb. 23, 2025 /PRNewswire/ — Aeroband, the pioneer in smart music technology, is proud to announce that it is selected as the exclusive music instrument brand for the 56th NAACP Image Awards® Official Celebrity Gift Lounge, honoring Black excellence in entertainment, music, and culture. Through this partnership, Aeroband celebrates the creative power of music and its ability to transcend boundaries, just as the NAACP celebrates outstanding achievements in the arts.

Aeroband at the 56th NAACP Image Awards
Aeroband at the 56th NAACP Image Awards

Innovation Meets Music

Aeroband, a brand committed to breaking barriers in music innovation, celebrates the artists, creators, and changemakers who shape the world through their talent and passion. This partnership with the NAACP Image Awards reflects Aeroband’s core belief that music should be boundless—just like the impact of those honored at the event.

“Our mission is to give musicians, whether they are seasoned artists or newcomers, the freedom to create and perform without limitations,” said Frank Niu, Founder and CEO of Aeroband. “As the world’s leading smart musical instruments, Aeroband provides products like the Aeroband Guitar and PocketDrum, which allow music lovers to express themselves anywhere, anytime—whether they’re on stage, in a studio, or even in their living rooms. These products are designed to make music creation as intuitive and liberating as the diverse voices celebrated at the NAACP Image Awards.”

Campaign Highlights:

  • Exclusive Gifting: Celebrities and honorees will receive Aeroband Guitar and PocketDrum, unlocking new ways to experience music through cutting-edge technology.
  • Interactive Music Experience: VIP guests will have the opportunity to try Aeroband’s revolutionary instruments in a one-of-a-kind sound booth at the event.
  • Social Media Challenge: #UnleashTheRhythm – Fans and celebrities will showcase their Aeroband music skills, proving that music has no boundaries.

For more information, please visit https://www.aeroband.net/pages/the-naacp-image-awards

Aeroband Guitar: Aeroband Guitar is a smart, portable instrument perfect for music lovers. It features a built-in speaker, an external microphone, and connectivity to external speakers via a 1/4-inch output. The guitar offers multiple sound modes, including piano sound. As a new-generation guitar, the Aeroband Guitar makes practicing and learning easier than ever—allowing beginners to quickly learn. For creators, the Aeroband Guitar also offers MIDI functionality, opening up endless possibilities for music production and composition. Whether you’re a novice or a pro, this guitar empowers everyone to explore their musical creativity with ease.

  • Interactive lessons & real-time feedback
  • Multi-tone
  • Detachable neck for easy on-the-go use
  • MIDI controller

PocketDrum: PocketDrum is a portable, innovative air drumming instrument that transforms any surface into a responsive drum kit, allowing users to play anywhere, anytime. Perfect for drummers of all levels, PocketDrum offers an immersive, responsive experience that lets you explore rhythm and creativity anywhere, whether at home, in the studio, or on the go. Its quiet design ensures that you can practice without disturbing others, making it ideal for late-night sessions or shared living spaces. Additionally, PocketDrum features MIDI functionality, allowing you to connect to digital audio workstations and music production software, expanding your drumming capabilities to new levels of creativity.

  • Play anytime, anywhere
  • No disturb
  • Midi controller

Both the Aeroband Guitar and PocketDrum are available for purchase directly from our Aeroband website and on Amazon, making it easy for music lovers everywhere to access these innovative instruments. Whether you’re a beginner or a seasoned musician, these products are designed to bring out the best in your musical creativity.

About Aeroband

Aeroband as the world’s best smart musical instruments, dedicated to breaking barriers in music innovation. Known for its cutting-edge Aeroband Guitar and PocketDrum, the company enables users—from beginners to professionals—to explore their musical creativity anywhere, anytime.

About the NAACP Image Awards

The NAACP Image Awards is a prestigious event that honors outstanding achievements in the fields of entertainment, music, literature, and social justice. Celebrating Black excellence and cultural achievements, the awards are presented by the National Association for the Advancement of Colored People (NAACP). Since its inception, the NAACP Image Awards has been a platform to recognize and uplift the voices of Black artists, leaders, and activists who make significant contributions to the arts and society. The 56th NAACP Image Awards® Show will take place from the Pasadena Civic Auditorium, and will be broadcast live on Saturday, Feb. 22, 2025, at 8 p.m. ET/ 5 p.m. PT on BET.

Contact:
Lola Xu
Public Relations
Aeroband
Email: lola@aeroband.net
Website: https://www.aeroband.net

NetEase Cloud Music and Starship Entertainment Forge Copyright Partnership to Deliver Premium K-pop Content to Chinese Audiences

HANGZHOU, China, Feb. 23, 2025 /PRNewswire/ — Korean entertainment group Starship Entertainment has entered into a copyright partnership with China’s premier online music platform, NetEase Cloud Music. This agreement brings Starship’s complete catalog, including the latest hits from renowned Korean girl group IVE and their third mini album, “IVE EMPATHY,” to Chinese audiences. The partnership not only boosts Starship Entertainment’s profile in China but also diversifies the music offerings available to Chinese listeners with a wider array of musical styles.

The collaboration capitalizes on the unique strengths of both entities in content creation and distribution. NetEase Cloud Music, hailed as one of China’s top online music platform, enjoys widespread popularity among the nation’s youth. Its vibrant music community enhances the efficiency of music distribution and expands Starship Entertainment’s reach among young Chinese music fans. Official figures show that NetEase Cloud Music has 206 million monthly active users, with more than 31.4% engaging with recommended tracks, marking a shift from traditional listening habits to a more engaged and unified community.

K-pop continues to thrive on the NetEase Cloud Music platform, with numerous artists from Starship Entertainment already gaining substantial recognition and positive commentary on the platform. Notably, the girl group IVE boasts over 349,000 fans on NetEase Cloud Music, with several of their songs amassing more than 100,000 favorites shortly after release. This highlights K-pop’s growing impact within the NetEase Cloud Music community. 

The copyright partnership with Starship Entertainment is a significant milestone in NetEase Cloud Music’s ongoing commitment to strengthening its K-pop offerings. In recent years, the platform has established partnerships with major South Korean entertainment firms including SM Entertainment, JYP Entertainment, YG Entertainment, Kakao Entertainment, and CJ ENM. These alliances have enabled NetEase Cloud Music to continuously introduce high-quality K-pop music to the Chinese market. As a result, the platform has developed an extensive library of licensed K-pop music, establishing itself as a crucial gateway for Chinese music fans to explore and appreciate the genre.