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German Adventurer Selects Taipei as Her 80th Destination, Praising Safety and Cultural Depth

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TAIPEI, TAIWAN – Media OutReach Newswire – 2 December 2025 – German explorer Jana Alessa Bittner, currently on a solo mission to visit all 197 countries and become the youngest German woman to achieve this milestone, recently selected Taipei as the 80th stop on her global journey. Her early November visit highlighted the city’s reputation as a safe, welcoming and culturally rich destination for independent travelers.

Jana Alessa Bittner explores Dihua Street in vintage-style dress, immersing herself in Taipei’s historic atmosphere.
Jana Alessa Bittner explores Dihua Street in vintage-style dress, immersing herself in Taipei’s historic atmosphere.

During her stay, Bittner explored the historic Dadaocheng district and experienced a traditional qipao transformation at the Dadaocheng Visitor Center. Dressed in elegant vintage-style attire, she strolled along Dihua Street, passing preserved merchant houses, temples, herbal medicine shops, tea stores and vibrant street food stalls. The immersive experience allowed her to witness how Taipei seamlessly blends historical heritage with contemporary urban life.

Sharing her journey on Instagram, Bittner described the qipao walk as one of the highlights of her Taiwan trip and recommended that visitors reserve the experience online in advance. She encouraged travelers to explore Dihua Street in traditional attire, noting that the lively atmosphere enabled her to connect deeply with local culture — from historic architecture and community scenes to authentic Taiwanese cuisine and artisan boutiques.

The Taipei City Government Department of Information and Tourism stated that the Dadaocheng Visitor Center offers a complimentary retro costume experience as part of its efforts to promote immersive cultural tourism. This initiative provides visitors with an engaging gateway into Taipei’s history while showcasing the charm of old districts through interactive cultural experiences.

Taipei’s commitment to safety and inclusivity has also gained international recognition. In 2025, Time Out ranked Taipei as the world’s safest city for female digital nomads, citing its secure environment, efficient public transportation and traveler-friendly infrastructure. This distinction further strengthens Taipei’s appeal as a destination where solo female travelers can explore with confidence and peace of mind.

Through Bittner’s visit, Taipei once again demonstrates its appeal as a city where tradition and innovation coexist, offering meaningful cultural encounters alongside modern urban charm for global travelers seeking authenticity and inspiration.

More travel ideas and itineraries can be found on Travel Taipei: https://www.travel.taipei/en

Hashtag: #TaipeiCityGovernment

The issuer is solely responsible for the content of this announcement.

North American Edge: SIM’s US & Canada Partnerships Explained

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SINGAPORE – Media OutReach Newswire – 2 December 2025 – In today’s interconnected world, education is more than a credential, it is a passport to global opportunities. Singapore Institute of Management Global Education (SIM GE) exemplifies this vision through strategic partnerships with two leading North American institutions, the University at Buffalo (UB), The State University of New York, and the University of Alberta (UofA). These collaborations bring world-class degrees to Singapore, combining academic excellence with accessibility and flexibility.

Bringing North American Excellence to Singapore

North American universities are recognized for their rigorous standards, innovative teaching, and global outlook. SIM’s partnerships allow students to earn prestigious U.S. and Canadian degrees locally while enjoying opportunities for overseas exposure. This model offers affordability without compromising quality, making SIM a trusted gateway to international education.

University at Buffalo: A U.S. Flagship Institution

Founded in 1846, the University at Buffalo is the largest and most comprehensive campus in the State University of New York (SUNY) system and a member of the elite Association of American Universities (AAU). UB ranks among the top public universities in the United States, reflecting its strong academic reputation. At SIM, UB offers undergraduate programs in business and communication, backed by AACSB accreditation, the gold standard for business education worldwide. Only about six percent of business schools globally hold this accreditation, ensuring UB graduates meet international benchmarks in business knowledge and ethics.

UB’s programs at SIM are designed for efficiency and value. Students can complete their U.S. degree in just three years, compared to the traditional four-year program, and at a fraction of the cost. The curriculum blends core business principles with interdisciplinary learning, including courses in psychology, sociology, and technology, skills essential for thriving in today’s dynamic global economy. Faculty members include visiting professors from the U.S. and local experts, creating a rich, multicultural learning environment that mirrors the global workplace.

University of Alberta: Canada’s Premier Business School

On the Canadian front, SIM partners with the University of Alberta, ranked among the top four universities in Canada and consistently within the top 100 globally. Its Alberta School of Business holds the distinction of being the first and longest continuously AACSB-accredited business school in Canada, a testament to its enduring commitment to excellence.

SIM offers the MBA (FastTrack) program from UofA, tailored for business graduates seeking senior management roles. This program combines academic rigor with flexibility, allowing completion within one to two years. Students enjoy the same degree as those studying on campus in Canada, but at a significantly lower cost and with the convenience of remaining in Singapore. The program also provides career coaching and networking opportunities, equipping graduates with the tools to advance in competitive global markets.

AACSB Accreditation and Flexible Pathways: Your Passport to Global Leadership

Both UB and UofA share the hallmark of AACSB accreditation, a rigorous standard that signifies excellence in teaching, research, and curriculum development. For students, this means their qualifications are recognized worldwide, opening doors to careers across borders and industries. Beyond these flagship programs, SIM offers flexible pathways for lifelong learning, including part-time options, online learning, and articulation routes to other top universities. These pathways empower working professionals to upskill without sacrificing career progression, reinforcing SIM’s role as a lifelong learning partner.

Your Passport to Global Business Leadership

Choosing SIM’s North American programs is more than an academic decision, it is an investment in a future defined by global opportunities. Students gain a globally recognized degree from top-ranked universities, access to international faculty, and a curriculum that blends North American rigor with global relevance. In a world where borders are increasingly blurred, SIM equips its graduates to lead confidently on the international stage right from Singapore.

References:

  1. University at Buffalo – https://www.sim.edu.sg/degrees-diplomas/sim-global-education/university-partners-sim-ge/university-at-buffalo-the-state-university-of-new-york
  2. University of Alberta – https://www.sim.edu.sg/degrees-diplomas/sim-global-education/university-partners-sim-ge/university-of-alberta
  3. SIM Students overseas exposure – https://www.sim.edu.sg/getmedia/e71b6eb5-1484-45e7-9fe8-db7becd9e7ff/Academic-Prospectus_20Jul2022_1.pdf
  4. University at Buffalo AAU membership – https://www.buffalo.edu/news/key-issues/aau.html
  5. UB is ranked #36 among public universities and #75 nationally by U.S. News & World Report. – https://www.usnews.com/best-colleges/ub-9554
  6. Uofa ranked among the top four universities in Canada and top 100 globally – https://www.topuniversities.com/universities/university-alberta
  7. Alberta School of Business is the first and longest continuously AACSB-accredited business school in Canada – https://www.ualberta.ca/en/business/news/articles/2021/01/aacsb-accreditation.html

Hashtag: #SIMGlobalEducation #SIMGE

The issuer is solely responsible for the content of this announcement.

About SIM Global Education

SIM Global Education (SIM GE) is a leading private education institution in Singapore and the region. We offer more than 140 academic programmes ranging from diplomas and graduate diploma programmes to bachelor’s and master’s degree programmes with some of the world’s most reputable universities from Australia, Canada, Europe, United Kingdom, and the United States. SIM GE’s cohort is made up of 16,000 full- and part-time students and adult learners, of which approximately 36% are international students hailing from over 50 countries.

SIM GE’s holistic learning approach and culturally diverse learning environment aim to equip students with knowledge, industry skills and employability competencies, as well as a global perspective to succeed as future leaders in a fast-changing, technologically driven world.

For more information on SIM Global Education, visit sim.edu.sg

Equiti Group strengthens multi-asset offerings with TraderEvolution partnership

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DUBAI, UAE, Dec. 2, 2025 /PRNewswire/ — Equiti Group, a global fintech provider, has partnered with TraderEvolution, a multi-market trading platform provider known for its modular, customisable solutions for brokers and banks worldwide. The partnership marks a key step in the Group’s work to deliver faster and more flexible trading across regions, giving clients greater responsiveness in rapidly changing markets and the tools they need to make informed decisions in different trading environments.

TraderEvolution’s technology enables broader product access, stronger execution and a smoother operational flow. The partnership will support new asset classes and improved platform performance, allowing Equiti to deliver a more advanced trading offering and maintain world-class solutions for clients worldwide.

Commenting on the agreement, Husam Al Kurdi, Equiti Cyprus CEO, said: “This partnership with TraderEvolution aligns with our ambition to widen the product range and market access available to our clients. It complements the strong foundation we already have in place and supports our ongoing work to provide a seamless and adaptable trading experience across regions. Our priority is to ensure clients have the reach and usability required to navigate global markets confidently.”

Roman Nalivayko, CEO, TraderEvolution Global said: “We are delighted to see a growing number of well-established brokerages selecting TraderEvolution as their core trading engine. TraderEvolution’s multi-asset strengths and back-end-first architecture give brokers unparalleled control and flexibility, empowering them to efficiently manage operations across all asset classes and deliver a seamless, customizable trading experience for their clients.”

The agreement lays the foundation for continued collaboration, strengthening Equiti’s commitment to delivering innovative, high-performance trading solutions that empower clients worldwide.

About Equiti

Equiti Group is a global leader in advanced trading technology, payment software, virtual assets, asset management and physical commodity solutions. With a presence across Africa, Asia, Europe and the Middle East, the Group is licensed in major financial jurisdictions including the UK, UAE and Cyprus. The Group delivers a best-in-class financial experience to clients across retail, professional, and institutional segments. Learn more at www.equiti.com

About TraderEvolution Global

TraderEvolution is a multi-market trading platform provider offering modular, customisable solutions for brokers and banks worldwide. The system includes a powerful back-end with connectivity to dozens of global exchanges and a versatile front-end suite – supporting native interfaces, third-party front-ends, and a Client API. Built to handle multiple asset classes across diverse market structures, TraderEvolution goes beyond the typical “multi-asset” claim, delivering true flexibility in both instrument coverage and market adaptability. The platform is liquidity-neutral and infrastructure-independent, enabling firms to run core brokerage operations or enhance existing setups.

 

Biel Crystal donates HK$10 million to support Hong Kong Tai Po Fire relief

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HONG KONG, Dec. 2, 2025 /PRNewswire/ — A major fire recently occurred at Wong Fook Court in Tai Po, Hong Kong, causing significant casualties and property damage, which has touched the hearts of people from all walks of life. Biel Crystal Holdings Limited donates HK$10 million for emergency relief and post-disaster reconstruction efforts.

The donation will be used through official channels to ensure efficient allocation of resources. It will be mainly used for key aspects such as emergency resettlement of affected residents, medical assistance, supply of basic living materials, and post-disaster reconstruction.

Dr YEUNG Kin-man, President of Biel Crystal, said, “We are deeply saddened by this sudden disaster. Biel Crystal is willing to work together with people from all walks of life to provide timely assistance to the affected families, help them rebuild their homes and return to normal life.”

Biel Crystal extends it’s highest respect to all the firefighters and rescue personnel battling on the front lines! We will closely monitor the situation and stand with our compatriots in Hong Kong to overcome this difficult time.

Biel Crystal donates HK$10 million to support Hong Kong Tai Po Fire relief
Biel Crystal donates HK$10 million to support Hong Kong Tai Po Fire relief

 

Royal Group Celebrates the Success of “Rise for Khmer” Concert, Reaffirming Its Commitment to Culture, Unity, and National Progress

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SINGAPORE and PHNOM PENH, Cambodia, Dec. 2, 2025 /PRNewswire/ — Royal Group is proud to announce the resounding success of the Rise for Khmer, Stand for Peace concert held at Salle Pleyel, Paris. An event that powerfully celebrated Cambodian resilience, culture, and unity. The concert was graciously attended by Her Excellency, Phoeurng Sackona, Minister of Culture and Fine Arts of Cambodia, whose presence further underscored the importance of preserving and uplifting Khmer identity and artistic expression.

Since 1991, under the visionary leadership of Chairman Neak Oknha Kith Meng, Royal Group has been more than a business. It is a Cambodian institution — built by Cambodians, for Cambodia — rooted in the belief that the nation’s progress must be shared, meaningful, and enduring.

Since 1991, under Chairman Neak Oknha Kith Meng, Royal Group has become a Cambodian institution built by Cambodians, for Cambodia.
Since 1991, under Chairman Neak Oknha Kith Meng, Royal Group has become a Cambodian institution built by Cambodians, for Cambodia.

Rise for Khmer, Stand for Peace represents far more than a musical event. it embodies the spirit of the Cambodian story: a nation once challenged, rebuilt through perseverance, and continuing to rise with dignity, humility, and unyielding strength.

Rise for Khmer, Stand for Peace reflects Cambodia’s resilient journey—rising with dignity, humility, and unwavering strength through past and present challenges.
Rise for Khmer, Stand for Peace reflects Cambodia’s resilient journey—rising with dignity, humility, and unwavering strength through past and present challenges.

Speaking on behalf of the organization, the Royal Group of Companies’ representative reinforced the Group’s dedication under the leadership of Neak Oknha Kith Meng: “At Royal Group, we believe that unity, compassion, and peace are the foundations of a strong Cambodia. Our investments — from telecom to banking to hospitality — touch millions of Cambodian lives every day. Supporting Khmer arts, both locally and abroad, reflects our dedication to preserving and celebrating what makes us uniquely Cambodian.”

The event served as a powerful reminder of the strength of community, particularly during challenging times faced by those living along the border.

Royal Group supports “Rise for Khmer,” showcasing Cambodian spirit globally and reinforcing unity, resilience, and community strength, especially for affected families from border conflicts.
Royal Group supports “Rise for Khmer,” showcasing Cambodian spirit globally and reinforcing unity, resilience, and community strength, especially for affected families from border conflicts.

Chairman Neak Oknha Kith Meng has mentioned on his current post about this concert that:
“No matter how long the night, the Khmer spirit always reaches for dawn. And when that dawn rises, we rebuild again — not just for ourselves, but for those who come after us. It is not about how high we rise; it is about how many we bring with.”

The successful concert was brought together by Khmer Artists Association, under the leadership of Lok Chumteav Neak Oknha Mao Chamnan, President of the Khmer Artists Association, in collaboration with Baramey Productions and Sabay Events Productions, and supported by Ministry of Culture and Fine Arts of Cambodia.

Sino Jet Finalizes 50-eVTOL Order with Aerofugia, Accelerating Low-Altitude Mobility Strategy

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HONG KONG, Dec. 2, 2025 /PRNewswire/ — At AERO Asia 2025, Sino Jet, the Asia-Pacific’s biggest business aviation company, has formally executed a definitive procurement contract for 50 units of the AE200 eVTOL through collaboration with Aerofugia, China’s premier electric vertical takeoff and landing vehicle manufacturer. This strategic maneuver constitutes Sino Jet’s proactive initiative to architect a comprehensive three-dimensional transportation infrastructure, delivering frictionless, environmentally sustainable, and highly efficient next-generation mobility solutions to discerning clientele. The agreement officially inaugurates the “business aviation + eVTOL” revolutionary transportation paradigm into an unprecedented scale of delivery and commercial deployment.

Strengthening Strategic Collaboration for a New Low-Altitude Mobility Ecosystem

Since establishing a strategic partnership and signing a letter of intent for 100 eVTOLs in 2023, the two parties have advanced their collaboration from joint product development to co-creating application scenarios and co-building infrastructure. The execution of these initial 50 AE200 firm orders represents a pivotal advancement in the strategic collaboration between Sino Jet and Aerofugia, advancing from conceptual framework to concrete implementation, thereby establishing a commercially-oriented deep integration paradigm. Leveraging internationally certified highest-standard safety management protocols, extensive aviation asset management expertise, and comprehensive global service capabilities, Sino Jet is positioned to deliver full-scale commercial operational support for the AE200 eVTOL platform.

Addressing the assembly, Li Yuanfeng, Group President of Sino Jet, remarked: “We are spearheading a fundamental paradigm shift in transportation methodologies. This partnership extends far beyond conventional aircraft acquisition, fundamentally concentrating on the synergistic integration of business aviation’s long-haul operational excellence with eVTOL’s adaptive short-haul connectivity capabilities, thereby establishing a secure, streamlined, and eco-conscious multi-dimensional transportation framework. Our mission encompasses extending our exemplary high-altitude operational standards to encompass the low-altitude transportation domain, thereby establishing transformative industry benchmarks.”

Focusing on Ecosystem Co-Building and Systematically Advancing eVTOL Commercialization

Ensuring robust strategic execution, Sino Jet will leverage core competencies to engage in comprehensive industrial collaboration with Aerofugia. Initially, concerning safety protocols, Sino Jet will methodically embed its internationally certified premier business aviation operational safety management framework into AE200’s operational architecture, encompassing continuous airworthiness oversight, Safety Management Systems (SMS) implementation, and comprehensive personnel development, thereby establishing superior safety parameters beyond conventional industry standards.

Regarding infrastructure development, Sino Jet will pioneer integration of its comprehensive national FBO network resources, strategically developing and implementing eVTOL landing facilities across principal commercial districts, thereby efficiently connecting the “last mile” of three-dimensional transportation.

Simultaneously, within commercial application exploration, Sino Jet will harness a sophisticated understanding of premium customer requirements, partnering to investigate varied deployment scenarios encompassing airport connectivity services, intercity transport networks, and cultural tourism destinations, ensuring optimal alignment between operational models and market specifications. For airport transit scenarios specifically, the eVTOL “point-to-point” air mobility framework is projected to diminish ground-based travel duration for downtown-to-airport journeys by 50%, successfully mitigating traffic congestion while delivering exceptional temporal value and operational predictability for clientele. The AE200 platform with capabilities including vertical takeoff/landing operations, zero-emission propulsion, minimal acoustic signature, 230 km/h maximum cruise velocity, and 200 km operational radius has emerged as the optimal infrastructure for realizing this strategic vision.

Co-Creating Green and Intelligent Aviation, Shaping the Future of Three-Dimensional Mobility

With the low-altitude economy formally designated as a national strategic emerging sector, China’s metropolitan air mobility market is experiencing unprecedented growth opportunities. Through this eVTOL procurement agreement execution, Sino Jet not only demonstrates visionary leadership in facilitating industrial transformation but also emphasizes corporate accountability for establishing a sustainable development trajectory. The “business aviation + eVTOL” multi-dimensional mobility framework will redefine high-end transportation paradigms, functioning as a vital conduit connecting principal urban metropolitan areas.

“We stand at the threshold of transportation methodology transformation,” Li Yuanfeng projected, “The execution of this 50-unit firm order commitment represents a significant milestone in our strategic partnership with Aerofugia. Looking forward, regulatory framework advancement and infrastructure maturation will catalyze the accelerated development of a comprehensive low-altitude transportation network linking core commercial districts, transportation nodes, and integrated urban clusters. Building upon this foundation, Sino Jet will persist in driving industry innovation, collaborating to inaugurate a new era in China’s low-altitude economy, delivering unprecedented temporal value and mobility experiences for our clientele.”

For queries please contact:
Sino Jet Marketing Department
Telephone: (+852) 2588 7007 / (+86 10) 8416 2637
Email: marketing@sinojet.org / marketing@sinojet.org.cn
Website: http://www.sinojet.org/

ZAGENO Receives Frost & Sullivan’s 2025 Global Company of the Year Recognition for Excellence in Life Sciences E-commerce Leadership

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ZAGENO earns global recognition for driving innovation, operational efficiency, and transformative customer value across the life sciences e-commerce ecosystem.

SAN ANTONIO, Dec. 2, 2025 /PRNewswire/ — Frost & Sullivan is pleased to announce that ZAGENO has been recognized with the 2025 Global Company of the Year Recognition in the life sciences e-commerce industry for its outstanding achievements in digital innovation, customer value enhancement, and strategic market execution. This recognition highlights ZAGENO’s consistent leadership in driving measurable outcomes, strengthening its global position, and delivering customer-centric innovation in a rapidly evolving life sciences landscape.

Frost & Sullivan evaluates companies through a rigorous benchmarking process across two core dimensions: visionary innovation & performance and customer impact. ZAGENO excelled in both, demonstrating its ability to align strategic initiatives with market demand while executing with scale, precision, and operational efficiency. “ZAGENO aligns closely with key technology trends shaping the life sciences industry by combining upstream integration, AI-driven automation, and personalized user experiences. The platform positions itself early in the procurement process, capturing product data directly from experiments through integrations with electronic lab notebooks and workflow automation tools,” said Amartya Bose, Senior Consultant at Frost & Sullivan.

Guided by a long-term growth strategy focused on digital innovation, global expansion, and deep customer partnerships, ZAGENO has demonstrated strong adaptability in a fast-changing market environment. The company’s continued investment in data-driven procurement intelligence and automation has enabled it to scale effectively across global biotechnology and pharmaceutical markets.

Innovation remains central to ZAGENO’s operating model. Its AI-powered, end-to-end procurement platform consolidates millions of SKUs, streamlines workflows, and enhances decision-making across lab, procurement, and finance teams. The platform offers enterprise-grade flexibility, scalability, and performance. “We are honored to receive Frost & Sullivan’s 2025 Global Company of the Year Recognition,” said Florian Wegener, Co-Founder and CEO of ZAGENO. “This acknowledgement underscores our belief that scientists, lab operations, and procurement teams deserve consumer-grade digital experiences that also meet the highest standards for compliance, data quality, and savings. By unifying millions of products, AI-driven guidance, and deep integrations into one platform, we help our customers accelerate R&D while making every dollar of lab spend work harder.”

ZAGENO’s unwavering commitment to customer experience further strengthens its market differentiation. By enabling seamless onboarding, supporting self-service procurement through a consumer-like interface, and maintaining high levels of platform reliability, the company delivers predictable, high-value outcomes for global life sciences organizations. Its customer-first engagement model, sustained support infrastructure, and localized partnership network have been instrumental in delivering long-term value across diverse customer segments.

Frost & Sullivan commends ZAGENO for setting a high standard in competitive strategy, execution, and market responsiveness. The company’s vision, innovation roadmap, and customer-centric culture continue to shape the future of the life sciences e-commerce industry while driving tangible operational and financial impact for clients worldwide.

Each year, Frost & Sullivan presents the Company of the Year Recognition to a company that demonstrates outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning. The recognition honors organizations that are redefining their industries through bold innovation, strategic excellence, and forward-looking leadership.

Frost & Sullivan Best Practices Recognition

Frost & Sullivan’s Best Practices Recognitions honor companies across regional and global markets that exhibit exceptional achievement and consistent excellence in areas such as leadership, technological innovation, customer experience, and strategic product development. Each recognition is the result of a rigorous analytical process in which Frost & Sullivan industry experts benchmark performance through comprehensive interviews, deep-dive analysis, and extensive secondary research. The goal is to identify true best-in-class organizations that are driving transformative growth and setting new industry standards.

Contact us: Start the discussion.

Contact:
Ashley Shreve
E: ashley.weinkauf@frost.com 

About ZAGENO

ZAGENO is the leading R&D lab supply procurement platform, bringing together Guided Buying, a Single-Entry Point (SEP), and AI-driven insights to streamline how scientists and procurement teams’ work. Researchers access 40M+ SKUs from 5,000+ brands with real-time availability, while procurement teams execute supplier strategies, consolidate orders, and enforce compliance. With fully automated source-to-pay workflows, ZAGENO removes manual work and maverick spend—saving money, saving time, and accelerating R&D through its industry-first Metacart and One-Creditor Model. Learn more at www.zageno.com.

Contact:
Stephanie Harold
E: stephanie.harold@zageno.com

Accord Healthcare Announces Launch of Denosumab∇ – Second Biosimilar in Bone Health

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∇ This medicine is subject to additional monitoring. This will allow quick identification of new safety information.

LONDON, Dec. 2, 2025 /PRNewswire/ — Accord Healthcare today announced the launch of Osvyrti (denosumab), a biosimilar to Prolia® (Amgen), and Jubereq (denosumab), a biosimilar to Xgeva® (Amgen), following the scheduled expiry of the reference medicine’s patent on 27 November 2025.

Both medicines were approved by the European Medicines Agency (EMA) in September of this year following trials versus their reference product showing they are highly similar to the Prolia® (Amgen).

Denosumab marks the company’s second biosimilar launch within its bone health portfolio, further expanding Accord’s commitment to improving patient access to high-quality, cost-effective medicines in areas of high clinical need.

Supporting clinicians and healthcare systems in bone health

Osvyrti (denosumab) available as a 60 mg pre-filled syringe is indicated for1:

  • The treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures.
  • The treatment of bone loss associated with hormone ablation in men with prostate cancer at increased risk of fractures.
  • The treatment of bone loss associated with long-term systemic glucocorticoid therapy in adult patients at increased risk of fracture.

Jubereq (denosumab) available as a 120 mg vial is indicated for2:

  • Prevention of skeletal related events (pathological fracture, radiation to bone, spinal cord compression or surgery to bone) in adults with advanced malignancies involving bone.
  • Treatment of adults and skeletally mature adolescents with giant cell tumour of bone that is unresectable or where surgical resection is likely to result in severe morbidity.

“Both OSVYRTI and JUBEREQ have been approved for a wide variety of bone-related indications, including osteoporosis and bone loss from the treatment of certain kinds of cancer,” said Paul Tredwell, Global CEO of Accord Healthcare. “These biosimilars have the potential to provide a large number of patients with treatment alternatives that lessen cost as a barrier to accessing proven therapies. At Accord, we are passionate about leading biosimilar adoption, and OSVYRTI and JUBEREQ represent important progress in expanding access, supporting our strategic drive to have 20 biosimilars on the market by 2030.”

Addressing the burden of osteoporosis

Osteoporosis is a chronic condition characterised by reduced bone mass and structural deterioration, leading to an increased risk of fractures.

It affects more than 200 million people globally, with around one in three women and one in five men over 50 years experiencing osteoporotic fractures in their lifetime. As populations age, the prevalence and economic impact of osteoporosis are expected to continue rising, placing additional pressure on healthcare systems.

OSVYRTI

  • Comparable increases in lumbar spine BMD at 12 months (6.25% vs. 6.36%).
  • Equivalent pharmacokinetic, pharmacodynamic, safety, and immunogenicity profiles.
  • Low anti-drug antibody incidence (≤1.6%) in both treatment groups, with no neutralising antibodies observed.
  • No impact on efficacy or safety following treatment switch from the reference medicine to Osvyrti.
  • These results support Osvyrti as a biosimilar and clinically interchangeable alternative to reference denosumab

JUBEREQ

  • Proven bioequivalence to the reference denosumab, with no clinically meaningful differences in efficacy, safety, pharmacokinetics profile or immunogenicity
  • Compared to their HRQOL status before experiencing their first SRE, patients with metastatic prostate cancer showed marked scores across quality-of-life domains following an SRE (Skeletal-Related-Events)
  • Superior, sustained prevention of skeletal related events for >2 years, delaying time to first event vs. zoledronic acid
  • No dose adjustments required in patients with renal impairment

Notes to editors:

  • Osvyrti (denosumab) is a biosimilar to Prolia® (Amgen).
  • The Phase 3 study (INTP23.1) was conducted in accordance with EMA and FDA biosimilar development guidelines.
  • Prolia® is a registered trademark of Amgen Inc.
  • This information is intended for healthcare and trade media and is not intended for use with patients or the general public.

About OSVYRTI and JUBEREQ
The approval of OSVYRTI and JUBEREQ was based on results from two trials: a Phase I trial and a Phase III trial that met their primary endpoints. The Phase I trial was a randomized, double-blind, three-arm pharmacokinetic (PK) study comparing JUBEREQ to Xgeva in healthy adult males. The study demonstrated that PK parameters were found to be comparable between the two products.4 The Phase III study was a randomized, double-blind, active-controlled, parallel arm, multicenter study comparing PK/PD, efficacy and safety of OSVYRTI to Prolia in postmenopausal women with osteoporosis. The clinical study results demonstrated that OSVYRTI and its reference product, Prolia, are highly similar, and have no clinically meaningful differences in terms of PK, PD, safety and efficacy.2,4

About Accord Healthcare
Accord Healthcare is one of the fastest-growing generic and biosimilar pharmaceutical companies in the UK and Europe. Through its focus on quality, accessibility, and sustainability, Accord works with healthcare professionals and the NHS to improve patient outcomes and deliver value across therapeutic areas including oncology, bone health, and autoimmune disease.

References:

  1. OSVYRTI® (denosumab-desu) Prescribing Information. Accord BioPharma.
  2. JUBEREQ® (denosumab-desu) Prescribing Information. Accord BioPharma.
  3. Amgen Reports Fourth Quarter and Full Year 2024 Financial Results.
    https://www.amgen.com/newsroom/press-releases/2025/02/amgen-reports-fourth-quarter-and-full-year-2024-financial-results
  4. Accord BioPharma. Data on file.

 

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