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Internet Watch Foundation and Public Interest Registry Extend Online Safety Initiative to Disrupt Criminal ‘brands’ Selling Child Sexual Abuse

A new sponsorship programme aims to help domain registrars ‘disrupt’ criminal businesses

Criminals running commercial child sexual abuse websites will be targeted under a new safety initiative which aims to disrupt their ability to buy domain names for their sites.

CAMBRIDGE, United Kingdom , Oct. 22, 2025 /PRNewswire/ — Today, Public Interest Registry (PIR), the US non-profit that operates the .ORG Top-Level Domain, and the Internet Watch Foundation (IWF) have announced a new partnership which will empower Domain Name Registrars to disrupt sites dedicated to the commercial distribution and exploitation of online child sexual abuse material.

A registrar is an accredited organisation which sells domain names to the public. Through the expanded partnership with PIR and IWF, all registrars will now be able to access IWF’s powerful tools to disrupt the distribution of child sexual abuse materials (CSAM) online at no cost. This will help registrars spot when criminal organisations which commercialise child sexual abuse imagery are attempting to set up “brands” with websites registered and used under different top-level domains and notify them when CSAM has been identified.

Domains specifically registered and used for the commercial distribution of child sexual abuse imagery are a deliberate abuse of the Domain Name System (DNS).

By signing up to the program, registrars will be alerted to the existence of dedicated commercial websites. This proactive approach could further disrupt the criminal abuse by making it more difficult for criminal organisations to register sites online.

Kerry Smith, Chief Executive at the Internet Watch Foundation, said: “In a world where so much is available to buy online, it is truly appalling to think that children’s distress and suffering are seen as commercial opportunities and commodities by organised criminals.

Indeed, there are recognisable brands within this world which trade in online child sexual abuse, making money from the hurt inflicted on real children.

This is where registrars can have such a big impact and help disrupt some of these awful businesses which prolong suffering, and fuel the demand for this content. PIR’s sponsorship will have an outsize impact in bringing powerful tools to more registrars.”

Jon Nevett, President and CEO of Public Interest Registry, said: “With today’s announcement, we are excited to evolve PIR’s partnership with the Internet Watch Foundation. Building on the success we have had with registries, expanding access to IWF’s services at no cost to the registrar community will be an important step in continuing to identify and remove harmful videos and images of CSAM and creating a safer Internet for all.”

Under the sponsorship, registrars will be able to sign up for free access to the IWF Domain Alerts program which provides real-time alerts if child sexual abuse content is detected on a domain they manage to allow for fast removal of content before it is further spread online.

This is an extension of an existing sponsorship which began in February 2024 which saw PIR sponsor other registries and registry service providers with free access to two important IWF services, Domain Alerts and the TLD (Top-Level Domain) Hopping List.

The increased access to these services helped ensure faster, more streamlined disruption to child sexual abuse imagery identified by the IWF and enable quick action to be taken to stop criminals hopping from one domain to another to keep their content online.

Since the initiative began in 2024, 30 registries – amounting to nearly 60 TLDs and more than 53 million domains – have benefitted from the sponsorship, greatly increasing the use of IWF services in this area.

Now, PIR is extending that sponsorship with the IWF to cover domain name registrars in addition to the existing sponsorship for registries which will continue.

Registrar access to these tools will become available in early 2026. To learn more about how your business can get involved, visit iwf.org.uk/membership. Interested Domain Name Registrars can contact the membership team directly at members@iwf.org.uk.

The public is given this advice when making a report to iwf.org.uk/report:

  • Do report images and videos of child sexual abuse to the IWF to be removed. Reports to the IWF are anonymous.
  • Do provide the exact URL where child sexual abuse images are located.
  • Don’t report other harmful content – you can find details of other agencies to report to on the IWF’s website.
  • Do report to the police if you are concerned a child may be in immediate danger.

Do report only once for each web address – or URL. Repeat reporting of the same URL isn’t needed and wastes analysts’ time.

Notes to editors:

The IWF is the largest hotline in Europe dedicated to finding and removing child sexual abuse material from the internet.

Contact:  Josh Thomas, Press Manager, josh@iwf.org.uk +44 (0) 7377 727058

Parents and carers are encouraged to T.A.L.K to their children about the dangers.

  • Talk to your child about online sexual abuse. Start the conversation – and listen to their concerns.
  • Agree ground rules about the way you use technology as a family.
  • Learn about the platforms and apps your child loves. Take an interest in their online life.
  • Know how to use tools, apps and settings that can help to keep your child safe online.

What we do:

We make the internet a safer place. We help victims of child sexual abuse worldwide by identifying and removing online images and videos of their abuse. We search for child sexual abuse images and videos and offer a place for the public to report them anonymously. We then have them removed. We’re a not for profit organisation and are supported by the global internet industry.

For more information please visit www.iwf.org.uk.

The IWF is part of the UK Safer Internet Centre, working with Childnet International and the South West Grid for Learning to promote the safe and responsible use of technology.

The IWF works globally to stop child sexual abuse imagery on the internet. If you ever stumble across a sexual image or video of someone you think is under 18, please report to the IWF. Reporting can be done anonymously and confidentially – we don’t need your details, just your help.

About Public Interest Registry

Public Interest Registry (PIR) is a nonprofit that operates the .ORG top-level domain—one of the world’s largest generic top-level domains with more than 11 million domain names registered worldwide. .ORG is open to everyone, providing a global platform for organizations, associations, clubs, businesses and individuals to bring their ideas to life. PIR has been a champion for a free and open Internet for two decades with a clear mission to be an exemplary domain name registry, provide a trusted digital identity and help educate those who dedicate themselves to improving our world. PIR was founded by the Internet Society (internetsociety.org) in 2002 and is based in Reston, Virginia, USA. Visit www.pir.org for more information.

Media contact: pir@berlinrosen.com

 

Guidepoint Unveils AI Moderation: Accelerate Expert Insights at Enterprise Scale

NEW YORK, Oct. 22, 2025 /PRNewswire/ — Guidepoint, a leading global expert network, today announced the launch of AI Moderation, a groundbreaking solution for gathering critical insights at scale. By enabling clients to conduct expert interviews without attending live calls, AI Moderation is able to increase the breadth and depth of perspectives gathered more efficiently and faster than ever before.

Guidepoint’s AI Moderation enables clients to extract high value knowledge at scale:

  • Increase Team Efficiency – Conduct dozens of interviews simultaneously without logistical constraints of coordinating and attending live calls
  • Start immediately – Launch consultations to deliver insights within hours, not days
  • Go truly global – 24/7 availability across time zones and geographies
  • Standardize quality – Consistent prompts and structured interviews deliver quality at scale

“Speed and quality shouldn’t be tradeoffs,” said Albert Sebag, CEO at Guidepoint. “With AI Moderation, our clients capture more perspectives, more quickly, with a level of consistency that’s hard to achieve in traditional workflows. It rapidly becomes a force multiplier alongside our live 1-to-1 expert calls.”

AI Moderation plugs directly into Guidepoint’s ecosystem. Clients can seamlessly combine live interviews and AI Moderation within the same project, enhancing the speed and efficiency of research initiatives while maintaining the same rigorous compliance and quality expectations. They can then synthesize their findings via AskGP, Guidepoint’s conversational AI assistant, turning unstructured conversations into active intelligence in one integrated flow.

Guidepoint AI Moderation is already proven to provide value under real-world conditions. Guidepoint has successfully facilitated thousands of interviews for early-adopter clients in addition to producing “AI-Guided” transcripts for its own content Library, using the same AI interviewer solution now broadly available to clients.

For more information on how you can leverage AI Moderation, contact a Guidepoint representative at sales@guidepoint.com.

About Guidepoint
Guidepoint connects clients with vetted subject matter experts from its global professional network. Guidepoint’s broad range of services empowers clients to access new industries, get up to speed on trending topics, conduct in-depth exploration of critical subjects, and validate qualitative insights. Guidepoint’s multinational client base includes top consulting firms, hedge funds, private equity firms, and Fortune-ranked public companies.

For more information, visit www.guidepoint.com.

Related Links
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Next-Gen Powerhouse: nubia Z80 Ultra Launches Globally, Delivering Elite Gaming and Revolutionary Photography via Snapdragon® 8 Elite Gen 5

SHENZHEN, China, Oct. 22, 2025 /PRNewswire/ — nubia, a global leader in smartphone innovation, introduces the nubia Z80 Ultra. The overseas version of this exceptional smartphone will be officially launched on November 6th. The nubia Z80 Ultra promises users an unparalleled experience and will be available for purchase starting from November 18th.

“Innovation has always been the core of nubia’s brand identity and the driving force behind our progress, creating a versatile smartphone that excels in both photography and gaming.” Ni Fei, President of Nubia Technology Co., Ltd.

Unrivaled Power and Endurance: Performance, Gaming, and Photography

The nubia Z80 Ultra is built for both immersive entertainment and sustained power, driven by the Snapdragon® 8 Elite Gen 5 mobile platform for exceptional performance, seamless multitasking, and high-quality gaming via the REDMAGIC-inspired CUBE Gaming Engine. This experience is visually enhanced by the customized BOE X10 1.5K ultra-clear full-screen display, which maximizes visual clarity for immersive content consumption. Complementing this is a versatile dual focal-length system featuring 5th-generation 35mm and 18mm lenses for capturing stunning photos and videos in any setting. Finally, boasting a powerful 7200 mAh battery, along with 80W wired and 80W wireless charging capabilities (accessible with the original nubia 80W wireless charging kit), ensures users stay connected and powered up throughout the day, eliminating concerns about running out of battery.

Featuring a unique design in black, white, and blue, it offers a personalized touch thanks to its physical button shutter, providing enhanced control when taking photos, while the professional-grade AI imaging model simplifies photography by optimizing settings for different scenarios, making it easier for users to achieve stunning results. The nubia Z80 Ultra is tailored to enhance everyday experiences, whether in photography, entertainment, or performance.

Dual Focal Lengths for Dynamic Mobile Photography with a Full-Screen Display

The nubia Z80 Ultra smartphone revolutionizes mobile photography and display technology with its advanced features designed to enhance the user experience. The device is equipped with a stunning BOE X10 1.5K Under-Display Camera full-screen display, delivering vibrant colors and exceptional clarity for an immersive visual experience, whether streaming videos or browsing photos.

Its 3000Hz instant touch sampling rate ensures lightning-fast response times and precise touch control. With a remarkable brightness of 2000 nits, visibility is guaranteed even in bright sunlight, while the integration of a Synaptics touch chip enhances navigation and interaction accuracy.

The nubia Z80 Ultra empowers users with versatile, professional-grade photography thanks to its 1/1.3-inch Light & Shadow Master 990 sensor, which ensures unparalleled image quality and captures every detail with precision, even in challenging low-light conditions. Designed for versatility, the system features customized 18mm optics for expansive ultra-wide-angle shots, an ultra-clear macro lens for stunning close-ups, and a seamless zoom range from 18mm to 85mm to easily frame any subject. Finally, the inclusion of 21 filters offers endless creative possibilities, allowing users to effortlessly personalize their photography.

Maximum Gameplay: AI Super Frame Stabilization, Long Battery Life, and Upgraded Cooling System

Driven by the powerful Snapdragon® 8 Elite Gen 5 mobile platform, the nubia Z80 Ultra is equipped with an upgraded UFS 4.1 storage and LPDDR5X RAM, designed to optimize gaming performance, ensuring that users can enjoy demanding titles without compromise.

With the advanced CUBE Gaming Engine, derived from the renowned REDMAGIC series, the nubia Z80 Ultra maximizes power efficiency while delivering sustained high-frame-rate gameplay. Gamers will appreciate the device’s support for Super Resolution and Super Frame Rate, delivering stunning visuals at up to 2K resolution, and an impressive 144Hz refresh rate. The incorporation of AI Super Frame Stabilization guarantees smooth graphics even in fast-paced moments, enhancing the all-around gaming experience.

The nubia Z80 Ultra is engineered for endurance and durability, integrating an advanced composite liquid metal and oversized 3D Ice Steel VC cooling system. This technology boosts cooling area coverage by 35% for efficient heat dissipation, ensuring optimal, sustained performance during intense gaming without overheating or excessive power consumption. Furthermore, the phone is built to last with IP68 and IP69 dust and water resistance, and its magnetic NFC smart case provides both seamless connectivity for on-the-go gamers and the option to customize the design to express your unique personality.

Redefining Smartphone Aesthetics: Available in Three Colors, Featuring the New Retro Kit 2.0

The nubia Z80 Ultra embodies “performance aesthetics” with its unique natural curvature and four-sided curved bonding process, ensuring a comfortable and secure grip. The device boasts a robust crystal fiber body, a distinctive luminous red ring around the main camera, and a handy customizable shortcut key, available in black, white, and blue (the collector’s Starry Night Edition). Complementing this design is the newly upgraded Retro Kit 2.0, developed in collaboration with Fotorgear. Crafted from tech nano-leather, titanium-toned aluminum alloy, and premium full-grain leather, the kit provides a superior grip and refined texture. Its custom smart controls, tactile mechanical buttons, and programmable dials optimize the photography workflow from assembly to storage, transforming the act of shooting into a cherished ritual.

The nubia Z80 Ultra stands out as an all-around smartphone for photography enthusiasts who desire professional-grade results at their fingertips. The nubia Z80 Ultra emerges as the premier choice for serious gamers in search of unparalleled performance and reliability. Paired with the Retro Kit 2.0, this exceptional device not only pays homage to classic design but also embodies the spirit of modern innovation. The nubia Z80 Ultra is truly redefining the future of smartphone technology.

Discover More:
For more information on the nubia Z80 Ultra and to explore our full range of innovative devices, please visit the nubia Official Website.

Fibocom (0638.HK) Officially Listed on HKEX Main Board as the First “A+H” Wireless Communication Module Company

HONG KONG, Oct. 22, 2025 /PRNewswire/ — Fibocom (300638.SZ | 0638.HK), a global leading provider of wireless communication modules and edge AI solutions, commenced trading today on the Main Board of the Hong Kong Stock Exchange (HKEX), making history as the first Chinese wireless communication module company to achieve a dual A+H listing.


The listing ceremony began at 9:30 AM, with Chairman Zhang Tianyu and CEO Ying Lingpeng jointly striking the gong, symbolizing Fibocom’s official launch on the Hong Kong market. Attended by key industry figures, strategic partners, and honored guests, the event celebrated this historic milestone for the company.

Speaking at the ceremony, Chairman Zhang Tianyu emphasized:

Today’s listing is a milestone and a new beginning. Leveraging this achievement, we will continue to innovate, maintain our leadership in wireless module solutions, expand investments in edge AI and robotics, and grow our global presence, delivering superior products and services while creating greater value for customers. While strengthening the foundation of ‘Connecting Everything,’ we have fully embarked on a strategic upgrade toward ‘Intelligent Connectivity of Everything.’ Looking ahead, Fibocom is committed to deeply embedding AI into every scenario and device, achieving a transformative leap from simple connectivity to intelligent connectivity.”

Fibocom’s listing on HKEX marks a significant milestone in our global growth journey. We will continue expanding our international market presence, deepening collaborations with strategic partners worldwide, and maintaining our leadership in the wireless communication module sector. Harnessing our capabilities in communication, AI, and V2X, we remain committed to delivering innovative products and solutions across diverse industries, solidifying our position as the preferred global partner for module and edge AI solutions.

About Fibocom

Fibocom, founded in 1999, is China’s first wireless communication module company listed on both the A-share and H-share markets (300638.SZ, 0638.HK). As a global leading provider of wireless communication modules and AI solutions, Fibocom leverages wireless communication and artificial intelligence as its core technologies to provide integrated hardware and software solutions that empower industry applications. These solutions accelerate the transformation from “Connect Everything” to “Intelligent Connectivity” across diverse industries.

Fibocom’s one-stop solutions encompass cellular communication, AI, automotive, and GNSS modules, as well as AI toolchains, supporting industry-side and mainstream large model integration, and providing AI Agent, global connectivity, and cloud services, driving the digital intelligence upgrades in industries such as robotics, consumer electronics, low-altitude economy, intelligent transportation, smart retail, and smart energy.

National Treasure Returns to “Hunan”:The Zidanku Chu Silk Manuscripts(Volumes Ⅱ and Ⅲ)Incorporated into the Collection of Hunan Museum


CHANGSHA, HUNAN – Media OutReach Newswire – 22 October 2025 – On the morning of October 13, a ceremony for the transfer and incorporation of the Zidanku Chu Silk Manuscripts (Volumes Ⅱ and Ⅲ), namely The Five Elements Decree and The Offence and Defense Divination, into the collection of Hunan Museum was grandly held.

National Treasure Returns to "Hunan":The Zidanku Chu Silk Manuscripts (Volumes Ⅱ and Ⅲ) Incorporated into the Collection of Hunan Museum

Present at the ceremony were guests from both China and the United States, including Rao Quan, Vice Minister of Culture and Tourism and Director of the National Cultural Heritage Administration; Liu Hongbing, Member of the Standing Committee of the Hunan Provincial Party Committee and Director of the Publicity Department of the Hunan Provincial Party Committee; Jiang Difei, Vice Governor of Hunan Province; Tang Wei, Vice Director of the National Cultural Heritage Administration; and Chase Robinson, Director of he Smithsonian’s National Museum of Asian Art in the United States. All of them witnessed this historic moment together.

During the ceremony, Tang Wei, Vice Director of the National Cultural Heritage Administration, read out the Official Consignment Letter for the Zidanku Chu Silk Manuscripts. Chase Robinson, Director of the Smithsonian’s National Museum of Asian Art, delivered a speech. Liu Hongbing, Member of the Standing Committee of the Hunan Provincial Party Committee and Director of the Publicity Department of the Hunan Provincial Party Committee, and Rao Quan, Vice Minister of Culture and Tourism and Director of the National Cultural Heritage Administration, delivered speeches respectively.

At the end of the ceremony, Director Rao Quan and Minister Liu Hongbing handed over the Inventory of the Zidanku Chu Silk Manuscripts. This move marked the official return of the treasure works Order of The Five Elements Decree and The Offence and Defense Divination, which had been lost overseas for 79 years, to their homeland and their incorporation into the collection of Hunan Museum.

The Zidanku Chu Silk Manuscripts are the earliest silk manuscripts with the significance of classic works ever discovered in China. They systematically record contents such as astronomy, calendar, cosmology, and military divination in the pre-Qin period, and are indispensable precious material materials for the study of archaeology, philology, document studies, and the history of thought. The successful return of Order of The Five Elements Decree and The Offence and Defense Divination this time is a model case of China’s recovery of lost cultural relics through international cooperation, and their return and incorporation into the collection can be regarded as another major landmark achievement. This move not only supplements a crucial material chapter to the genealogy of Chinese civilization, but also the successful practice itself is a direct embodiment of the country’s cultural confidence and soft power. It sends a clear message to the world about China’s unwavering commitment to safeguarding its civilizational heritage, while providing a successful “Chinese approach” for the repatriation of such cultural assets.

As the original excavation site of the silk manuscripts, Hunan is the most ideal home for these treasures. Their return will enable Hunan Museum to combine the only existing original fragment of the Zidanku silk manuscript in China (which is in its collection) with other cultural relics of the Chu and Han dynasties to build a more systematic and in-depth research, interpretation, and exhibition system for Chu culture. With this as the core, the museum is committed to building a world-class academic highland for Chu culture research.

The return of the silk manuscripts is not only a “repatriation through time and space” of the memory of civilization, but also a harmonious echo of cultural exchanges between China and the United States. Hunan Museum stated that it will take this as a prologue to expand international cooperation, allowing these thousand-year-old ancient scrolls to shine with the glory of the times in their homeland and jointly writing a new chapter in the inheritance of civilization with the world.

Hashtag: #HunanMuseum

The issuer is solely responsible for the content of this announcement.

Blood Publishes Promising Results of IASO Bio’s Anti-GPRC5D CAR-T RD118 in Relapsed/Refractory Multiple Myeloma

SHANGHAI, NANJING, China and PLEASANTON, Calif., Oct. 22, 2025 /PRNewswire/ — IASO Biotherapeutics (“IASO Bio”), a biopharmaceutical company focused on the discovery, development, production, and commercialization of novel cell therapies, today announced that the Blood published the latest results of its independently developed fully human anti-GPRC5D CAR-T cell therapy, RD118, for the treatment of relapsed/refractory multiple myeloma (R/R MM). The study demonstrates that RD118 exhibited significant efficacy and a manageable safety profile in heavily pretreated R/R MM patients, offering new therapeutic hope for the patients with a poor prognosis.


The study entitled ‘Fully Human anti-GPRC5D CAR T-Cell Therapy RD118 Induces Durable Remissions in Relapsed/Refractory Multiple Myeloma’ has been published in Blood. Full text available at: https://doi.org/10.1182/blood.2025030559. This is an open-label, phase 1 dose-escalation and expansion study to evaluate the efficacy and safety of RD118 in the treatment of R/R MM, which was conducted at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, and Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (registered as NCT05759793 and NCT05219721).

A total of eighteen patients received RD118 infusion in this study, including 17 with R/R MM and 1 with a history of primary plasma cell leukemia (pPCL) who had relapsed after achieving complete remission. Among the 18 patients, the median age was 59.5 years, and the median line of prior therapies was 5. High-risk features included double-hit cytogenetics (50%), triple-class refractoriness (50%), penta-class refractoriness (22.2%), and prior anti-BCMA CAR-T therapy (38.9%). Following lymphodepletion with fludarabine and cyclophosphamide, patients received a single infusion of RD118 at one of three dose levels (1.0, 2.0, or 3.0×106 cells/kg) during the dose-escalation phase or 2.0×106 cells/kg in the expansion cohort. At a median follow-up of 17.0 months, results show that:

Efficacy: The overall response rate (ORR) was 94.4%, with 72.2% of patients achieving complete response or stringent complete responses (CR/sCR). Among the seven patients who had received prior BCMA-directed CAR T-cell therapy, the ORR was 85.7%, with 5 patients (71.4%) achieving CR/sCR. All three patients with extramedullary disease and the patient with pPCL achieved sCR and remained in remission at last follow-up. The median progression-free survival (PFS) was 18.2 months, with 12-month PFS and overall survival (OS) rates of 82.1% and 93.3%, respectively.

Safety: Cytokine release syndrome (CRS) occurred in 88.9% of patients, primarily grade 1-2. Only one patient developed grade 3 or higher CRS, which rapidly recovered with intensive management. One patient developed grade 3 immune effector cell–associated neurotoxicity (ICANS) which resolved within 72 hours. No cerebellar toxicities or treatment-related deaths were reported

ConclusionFully human anti-GPRC5D CAR-T therapy RD118 demonstrated a 94.4% ORR and a median PFS of 18.2 months with a manageable safety profile in heavily over pretreated R/R MM, including patients who relapsed after prior anti-BCMA CAR-T therapy.

Professor Mi Jianqing from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, commented: “Multiple myeloma remains an incurable malignant plasma cell disorder. While anti-BCMA CAR-T therapy has greatly transformed the treatment for relapsed/refractory patients, challenges such as antigen escape often leads to relapse, highlighting the need for novel targets to overcome these limitations. GPRC5D has attracted significant attention due to its high expression, specificity, and independence from BCMA. The current study results have validated its potential: among patients previously treated with anti-BCMA CAR-T therapy, RD118 achieved an 85.7% overall response rate, with 71.4% of patients reaching complete response, demonstrating that GPRC5D is a highly promising novel therapeutic target.”

Professor Chunrui Li from Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, commented: “The innovative design of RD118 is the foundation of its outstanding clinical performance. RD118 is a novel GPRC5D-directed CAR-T that incorporates a fully human nanobody (VHH) as its antigen-binding domain. This design provides distinct advantages over conventional scFv, it is expected to lower immunogenicity, and potentially enhanced persistence, offering a new approach to overcome the safety limitations of existing comparable therapies. Meanwhile, the construct also includes a 4-1BB and a CD3ζsignal domains, which support expansion and sustained anti-tumor activity. Together, these features position RD118 as a highly competitive next-generation CAR-T product.”

Ms. Jinhua Zhang, Founder, Chairwoman and CEO of IASO Bio, remarked: “We are delighted that the remarkable research results of IASO Bio’s independently developed anti-GPRC5D CAR-T product, RD118, for the treatment of R/R MM have been published in the prestigious international journal Blood. This achievement marks another significant milestone for the product following the IND approval from China’s NMPA in June 2024. The treatment landscape for multiple myeloma requires continuous innovation, and GPRC5D, alongside BCMA, are represents a crucial therapeutic target in this field. Developed based on our fully human antibody platform, RD118 is designed to provide a new treatment option for patients. It offers renewed hope particularly for those who have relapsed after prior anti-BCMA CAR-T therapy. This publication will further motivate us to advance the clinical development of RD118, with the goal of delivering this innovative therapy to more patients worldwide.”

About RD118

RD118 is an autologous T-cell immunotherapy product targeting G protein-coupled receptor class C group 5 member D (GPRC5D). It can identify and eliminate malignant tumor cells expressing GPRC5D. GPRC5D is highly expressed on multiple myeloma cells. However, in normal tissues, its expression is limited to plasma cells and hair follicle cells. Such a feature has made GPRC5D a promising safe and effective target for the treatment of multiple myeloma.

The antigen recognition domain of RD118 is developed from IASO Bio’s proprietary fully human single-domain antibody library. It has advantages of high affinity, high specificity, and low immunogenicity. The intracellular domain is a fusion of 4-1BB (CD137) and CD3ζ signaling domains. RD118 has been subjected to extensive development and optimization in terms of antibody screening and structure design. The candidate molecule has demonstrated excellent in vitro cytotoxic activity and in vivo tumor suppression ability. Additionally, it has good expansion capability and persistence in vivo, indicating high development potential.

 

Bybit Unveils Fiat-to-Crypto Frenzy: 90,000 USDT Prize Pool for New Users

DUBAI, UAE, Oct. 22, 2025 /PRNewswire/ — Bybit, the world’s second-largest cryptocurrency exchange by trading volume, has announced the launch of its exclusive Fiat-to-Crypto Frenzy, a limited-time event designed for new users. The campaign offers participants the chance to share in a 90,000 USDT prize pool by completing simple onboarding and trading tasks.

Running from October 22, 2025, at 10:00 AM UTC until January 20, 2026, at 10:00 AM UTC, the event highlights Bybit’s fiat-to-crypto capabilities, which provide access to more than 300 digital assets. Through Bybit’s peer-to-peer (P2P) platform, users can seamlessly purchase popular tokens such as USDT, BTC and ETH, along with trending altcoins including DOGE, LAYER and MNT, using local fiat currencies.

The Fiat-to-Crypto Frenzy introduces a task-based participation model, where new users who sign up and complete identity verification can unlock rewards. Tasks include making a minimum deposit of 20 USDT via P2P, Fiat Deposit or One-Click Buy, as well as trading at least 100 USDT in Spot. Successful completion of tasks provides participants with bonuses and lucky draw tickets, which serve as entries into weekly prize draws.

Each ticket grants one entry into the draws for the 90,000 USDT prize pool, distributed across the campaign period. Rewards will be delivered through Bybit’s Rewards Hub and can be claimed within 14 working days after the event concludes.

With this new initiative, Bybit continues to expand its offerings to meet the growing global demand for secure, user-friendly, and accessible crypto trading solutions.

The event is available exclusively to newly registered users who meet eligibility criteria, including completion of Individual Identity Verification Level 1 or Business Verification. Certain restrictions apply, including participants residing in the European Economic Area and other regions listed on Bybit’s restricted countries page.

#Bybit / #CryptoArk 

Bybit Unveils Fiat-to-Crypto Frenzy: 90,000 USDT Prize Pool for New Users
Bybit Unveils Fiat-to-Crypto Frenzy: 90,000 USDT Prize Pool for New Users

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving a global community of over 60 million users. Founded in 2018, Bybit is redefining openness in the decentralized world by creating a simpler, open and equal ecosystem for everyone. With a strong focus on Web3, Bybit partners strategically with leading blockchain protocols to provide robust infrastructure and drive on-chain innovation. Renowned for its secure custody, diverse marketplaces, intuitive user experience, and advanced blockchain tools, Bybit bridges the gap between TradFi and DeFi, empowering builders, creators, and enthusiasts to unlock the full potential of Web3. Discover the future of decentralized finance at Bybit.com.

For more details about Bybit, please visit Bybit Press
For media inquiries, please contact: media@bybit.com
For updates, please follow: Bybit’s Communities and Social Media

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Ampace Showcases More Economical and Efficient Energy Solutions at All Energy Australia 2025

MELBOURNE, Australia, Oct. 22, 2025 /PRNewswire/ — Ampace will take the stage at All Energy Australia 2025 (Booth GG123), unveiling its latest advances in battery technology and next-generation energy storage solutions. As a trusted energy innovator serving over 50 million customers across 30 countries and regions, Ampace continues to drive progress in reliability, sustainability and high-performance energy storage technology. With proven large-scale manufacturing capabilities and a zero-safety-incident record, the company empowers partners and industries worldwide to achieve a safer, smarter energy transition.

To better harness Australia’s abundant solar resources and stabilize the grid amid rapid renewable expansion, Ampace will present innovations that help Australian industries and households optimize solar use and accelerate their energy transition. At this year’s exhibition, the showcased products include commercial & industrial (C&I), residential (RESS), UPS, and portable power applications.

At the show, Ampace will highlight three pillars of its innovation: unparalleled battery longevity, system-level efficiency, and advanced safety technologies.

  • Redefining Battery Longevity with the Kunlun Series

At the heart of Ampace’s innovation lies the Kunlun series battery cells, engineered for ultra-long lifespan and exceptional reliability. Capable of delivering up to 15,000 charge–discharge cycles—nearly twice the industry average—Kunlun batteries extend system lifespan up to 20 years. This advancement eliminates costly mid-life replacements and reduces total lifecycle electricity costs by up to 30%

  • Reimagining Efficiency with the UniC AG256-125

Integrated with Kunlun cells, the UniC AG256-125 all-in-one system is purpose-built for commercial and industrial users seeking high performance with minimal maintenance. Its Zero Liquid Cooling and Zero Air Conditioning design cuts lifetime energy use and requires one maintenance check per year. Proven in large-scale deployment in Chile, the UniC system has helped customers save over USD 1.2 million annually, delivering both economic and environmental benefits.

  • Pioneering Safety with Semi-Solid Technology

Ampace will showcase its mass-produced semi-solid-state LFP battery cells—engineered for outstanding safety, energy density, and operational stability from data centers to homes. Featuring 20% higher energy density and zero thermal runaway, the technology eliminates fire risk and enhances lifecycle reliability. It will be demonstrated in the PU200 and PR-S4 systems to be unveiled at the exhibition.

Join Ampace at All Energy Australia 2025 — and experience firsthand Ampace’s next-generation solutions driving the global energy transition.

Booth GG123
October 29-30
Melbourne Convention and Exhibition Centre (MCEC), Melbourne