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NYSE CONTENT ADVISORY: PRE-MARKET UPDATE FOR MARCH 3RD

NEW YORK, March 3, 2025 /PRNewswire/ — The New York Stock Exchange (NYSE) is proud to offer a daily pre-market update directly from the NYSE Trading Floor. The NYSE façade was illuminated over the weekend to raise awareness of Rare Disease Day, which took place on Friday, February 28th.

 

NYSE CONTENT ADVISORY: PRE-MARKET UPDATE FOR MARCH 3RD

Trinity Chavez delivers the pre-market update on March 3rd

  • Investors look ahead to Fed Chair Jerome Powell’s comments on Friday
  • Anticipating a week of key economic reports, including jobless claims
  • Markets aim for a strong response after last week’s mixed performance

Watch NYSE TV Live every weekday 9:00-10:00am ET 

 

Bruno Marc Redefines Men’s Oxford Shoes for Spring 2025

Distinct Designs for Every Defining Moment — From Office to Weekend

NEW YORK, March 3, 2025 /PRNewswire/ — The Bruno Marc Spring 2025 Men’s Oxford Collection redefines what it means to wear an Oxford. Designed for men who demand sophistication without sacrifice, this collection seamlessly blends classic craftsmanship with cutting-edge comfort, delivering lightweight flexibility, effortless polish, and all-day ease. Whether stepping into the boardroom, out on the town, or anywhere in between, this collection empowers men to move with confidence. 

Bruno Marc redefines classic dress shoes with its Oxford Collection, seamlessly blending timeless sophistication with premium sneaker-like comfort. This innovative lineup ushers in a new era of performance-driven elegance.
Bruno Marc redefines classic dress shoes with its Oxford Collection, seamlessly blending timeless sophistication with premium sneaker-like comfort. This innovative lineup ushers in a new era of performance-driven elegance.

With an unwavering commitment to redefining modern luxury, Bruno Marc has engineered a collection that challenges the limitations of traditional dress shoes. By fusing timeless Oxford sophistication with premium sneaker comfort, the Oxford Collection brings a new era of performance-driven elegance—because the right shoes don’t just complement an outfit; they set the tone for success.

Spring Forward in Revolutionized Oxfords for Every Moment 

BUSINESS CASUAL: The Competitive Edge in Style 

For professionals who demand sharp style with all-day comfort, this selection delivers an effortless transition from work to after-hours. Whether dominating meetings, leading presentations, or networking over dinner, these Oxfords redefine business casual with a performance-driven edge.

  • CrossFlex GentEdge – A refined yet relaxed Oxford with a premium vegan leather upper, arch-supporting cushioning, and a flexible sole for power moves with ease.
  • MaxFlex SuiteCraft – Designed for next-level comfort, this breathable wingtip Oxford features moisture-wicking lining, shock-absorbing support, and a lightweight, modernized design.
  • KnitFlex SmartCraft – A tech-driven Oxford with a stretch-knit upper, cushioned midsole, and grippy outsole for superior traction and step-by-step comfort.

ACTIVE: Laid-back, never off your game. 

For the man who moves through life with ease, this lineup blends refined style with luxurious, sneaker-like comfort. Whether grabbing coffee, navigating city streets, or meeting friends for brunch, these versatile designs deliver effortless sophistication with every step.

  • MaxFlex ActiveMetro – A hybrid Oxford-sneaker with a breathable knit upper, responsive cushioning, and slip-resistant traction — all the polish, none of the stiffness.
  • Theo sneakers – A certified slip-resistant work shoe with a shock-absorbing EVA midsole, designed for all-day wear in work settings without compromising style.
  • Sage Slip-On Loafers – A modern, easygoing loafer with a lightweight sole, stretch-knit upper, and cloud-like comfort for all-day ease.

DRESS: Big Stage, Big Style.

These styles are built for life’s defining moments—whether it’s a wedding, anniversary, graduation ceremony, or milestone celebration. Designed for the modern gentleman, these Oxfords combine timeless aesthetics with next-generation comfort and flexibility.

  • MaxFlex SuiteCraft – A statement wingtip Oxford that merges classic detailing with modern performance technology for style that rises to every occasion.
  • CrossFlex NeatPolish+ – A sleek and structured dress shoe with a genuine vegan leather upper, advanced arch support, and a shock-absorbing footbed for effortless sophistication.
  • Everett Classic Velvet Loafers – A show-stopping slip-on featuring a patent vegan leather upper, luxe velvet detailing, and a TPR outsole for a polished, elevated finish.

Designed for the Modern Man: Lightweight. Flexible. Unstoppable.

Traditional dress shoes often come with a trade-off between style and comfort—but not anymore. The Bruno Marc Spring 2025 Oxford Collection is made with premium materials, performance-inspired outsoles, and innovative cushioning, ensuring that every step is as smooth as it is stylish. With ergonomic footbeds, breathable linings, and lightweight flexibility, these Oxfords are made for the man who refuses to be slowed down—whether he’s stepping into the office, onto the streets, or onto life’s biggest stages.

Step Into the New Era of Oxfords

Spring style calls for versatility, comfort, and effortless polish—and the Bruno Marc Spring 2025 Oxford Collection delivers. From high-stakes boardrooms to casual rooftop gatherings, these five styles ensure you’re always stepping forward in confidence.

Available Now

Explore the Bruno Marc Oxford collection on Amazon, Official Website, TikTok, JustFab, and in selected retail stores. Step into this season’s most coveted styles and elevate your wardrobe with our exceptional range of Oxfords. Discover unparalleled value and quality, where timeless design meets enduring comfort.

About Bruno Marc

Bruno Marc is on a mission to redefine modern luxury, offering impeccably crafted footwear that embodies sophistication without the premium price. With an unwavering commitment to quality and refinement, Bruno Marc delivers shoes that blend timeless elegance with contemporary style, making high-end fashion accessible to every man. By prioritizing craftsmanship and attention to detail, Bruno Marc ensures that luxury is not just a statement but a standard, bringing a touch of sophistication to everyday life.

Tantech Holdings Regains Compliance with NASDAQ Minimum Bid Price Requirement

LISHUI, China, March 3, 2025 /PRNewswire/ — Tantech Holdings Ltd (NASDAQ: TANH) (“Tantech” or the “Company”) announced today that on February 28, 2025, it received notification from The Nasdaq Stock Market LLC (“NASDAQ”) confirming the Company has regained compliance with NASDAQ’s minimum bid price requirement under Listing Rule 5550(a)(2). NASDAQ noted this matter is now closed.

About Tantech Holdings Ltd

For the past decade, Tantech has been a highly specialized high-tech enterprise producing, researching and developing bamboo charcoal-based products with an established domestic and international sales and distribution network. Since 2017, when the Company acquired 70% of Shangchi Automobile, a vehicle manufacturer based in Zhangjiagang City, Jiangsu Province, it has manufactured and sold vehicles. The Company established two new subsidiaries, Lishui Smart New Energy Automobile Co., Ltd. and Zhejiang Shangchi New Energy Automobile Co., Ltd., in November 2020, to produce and sell street sweepers and other electric vehicles. The Company is fully ISO 90000 and ISO 14000 certified and has received a number of national, provincial and local honors, awards and certifications for its products and scientific research efforts. The Company’s subsidiary, First International Commercial Factoring (Shenzhen) Co., LTD, is engaged in commercial factoring for businesses in and related to its supply chain. For more information please visit: https://tanhtech.com/.

Forward-Looking Statements

This news release contains forward-looking statements as defined by the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements concerning the sales, plans, objectives, goals, strategies, future events or performance, and underlying assumptions and other statements that are other than statements of historical facts. These statements are subject to uncertainties and risks including, but not limited to, product and service demand and acceptance, changes in technology, economic conditions, the impact of competition and pricing, government regulations, and other risks contained in reports filed by the Company with the Securities and Exchange Commission. All such forward-looking statements, whether written or oral, and whether made by or on behalf of the Company, are expressly qualified by this cautionary statement and any other cautionary statements which may accompany the forward-looking statements. In addition, the Company disclaims any obligation to update any forward-looking statements to reflect events or circumstances after the date hereof.

For more information, please contact:

Tantech Holdings Ltd
Investor Relations
Tel: +86 (578) 226-2305
ir@tantech.cn

/C O R R E C T I O N — Chivas Regal/

In the news release, CHARLES LECLERC AND CHIVAS REGAL HIT THE RIGHT NOTE IN NEW GLOBAL PARTNERSHIP, issued 02-Mar-2025 by Chivas Regal over PR Newswire, we are advised by the company that the name of the signature cocktail after the last paragraph, should read “Leclerc” rather than “Le Clerc”, and ‘The Leclerc Spritz’ rather than ‘The Monaco Spritz’ as originally issued inadvertently. The complete, corrected release follows:

CHARLES LECLERC AND CHIVAS REGAL HIT THE RIGHT NOTE IN NEW GLOBAL PARTNERSHIP

Chivas Regal welcomes Charles Leclerc as Global Brand Ambassador with an exclusive pop-up piano bar ahead of the first Grand Prix of the season, with an appearance from the self-taught pianist.

LONDON, March 3, 2025 /PRNewswire/ — Luxury Scotch whisky, Chivas Regal, has announced leading Formula 1 driver Charles Leclerc as its Global Brand Ambassador in a multiyear partnership, highlighting the brand’s growing influence in modern sports culture.

Charles Leclerc, Global Brand Ambassador at Chivas Regal
Charles Leclerc, Global Brand Ambassador at Chivas Regal

Throughout the collaboration, Chivas Regal and Charles will encourage fans to forge their own paths in redefining success. The partnership will celebrate the achievement of personal goals and creativity along the way, exploring Charles’ passion points off the racetrack, with the first being music.

As a talented and self-taught pianist and composer, Charles has been sharing his love of music with fans over the past few years that has seen him release multiple tracks. The time, precision and passion he puts into mastering the notes on a piano is reflective of the craftmanship required to blend the notes of an iconic whisky.

To celebrate this blending of success, Charles and Chivas Regal are hosting an exclusive, one-night-only pop-up piano bar which brings together the worlds of music and whisky. Dubbed Leclerc’s, the bar will open on March 11th in Melbourne, ahead of the 2025 Formula 1 season opener in the city later that week.

The immersive event will give VIP guests and a limited number of lucky fans the chance to enjoy bespoke Chivas Regal x Charles Leclerc whisky cocktails, while experiencing a unique evening, centred around music, inspired by Leclerc’s passion for the piano. The event will also feature a special guest appearance from Charles himself, marking the first of many moments he and Chivas Regal will celebrate together.

Those heading to Leclerc’s will have the opportunity to experience a new side of the racing legend as they explore the fusion and notes of whisky and music like never before, in an evening that celebrates the artistry of piano and the craft of whisky.

Nick Blacknell, Global Marketing Director, for Chivas Regal, at Chivas Brothers says: “It’s no secret Charles has had incredible success in his life, but it is his tenacious spirit, commitment to excellence and off-track passions that inspired this partnership. The 88 notes of the piano draw perfect parallels with the 85 flavour notes of our iconic Chivas 18 Year Old expression, showing how both music and whisky blend passion with precision. We’re excited to bring fans on the journey to celebrate our wins together – the ethos that lies at the heart of Chivas Regal.”

Charles Leclerc, Global Brand Ambassador at Chivas Regal, adds: “Success is about blending all the right notes – on and off the track. My craft demands time, precision, and dedication, but what truly drives me is the journey, my passions, and the moments shared along the way. Chivas Regal embodies this same ethos, encouraging people to find their own rhythm and celebrate every win, big or small. I’m excited to redefine success together and share this experience with fans through our partnership.”

To be in with a chance of winning a coveted spot at Leclerc’s in Melbourne and meet Charles, fans can head TimeOut Melbourne to enter and find out more. Closing date for entry is Saturday 8th March.

This marks the start of a collaborative partnership between Charles Leclerc and Chivas Regal, with further moments of celebration to come. Fans can keep up to date with the new partnership by following @ChivasRegal on Instagram or visiting Chivas.com

Please enjoy Chivas Regal responsibly and never drink and drive.

Notes to Editors           

For more information please contact: clcxchivas@wearetheromans.com 

For imagery please see HERE.

About Chivas

Chivas Regal is the original luxury blended Scotch whisky. Launched in 1909, Chivas has been integral to the growth of the Scotch whisky category worldwide – with a retail sales value today of over €2.07bn.

Chivas believes in celebrating the next generation of whisky drinkers who elevate themselves and those around them to forge new paths to success – which is why Chivas’ ethos is ‘I Rise, We Rise’, a nod to the importance of hard work, community and ripping up the rule book. These values were instilled by founding brothers James and John Chivas who pioneered the art of whisky blending in 19th century Scotland and became pillars of the community due to their tireless work ethic, hustle, and drive. Chivas continues this vision of collective success through its long-standing association with global sports culture, having enjoyed partnerships with Premier League football clubs for many years, and now in its latest move as ‘Official Team Partner’ of the Scuderia Ferrari HP Formula 1 team in a new global partnership.

Chivas blends its spiritual home in Speyside, Scotland, with more than 100 countries across the globe, who together have made Chivas the global success it is today. The Chivas range blends timeless classics with modern innovation and includes: Chivas 12, Chivas Extra, Chivas XV, Chivas Mizunara, Chivas 18, Chivas Ultis XX, Chivas 25, and Chivas Regal The Icon Chivas.

I Rise, We Rise.

www.Chivas.com

About Leclerc’s 

To celebrate Charles Leclerc as Chivas Regal’s Global Brand Ambassador, the racing legend and the luxury Scotch whisky are hosting an exclusive, one-night-only piano bar pop-up in Melbourne on March 11th, ahead of the 2025 Formula 1 season. The event brings together the two worlds of whisky and music, signalling the start of a collaborative partnership and marking the first of many moments he and Chivas Regal will celebrate together. 

Chivas Regal x Charles Leclerc Signature Serve – ‘The Leclerc Spritz‘ 

Charles Leclerc’s signature serve. A twist on an Italian classic fit for the French Riviera. 

  • 30ml Chivas Regal 18 Year Old
  • 30ml Elderflower Cordial
  • 20ml Lime Juice
  • 60ml Champagne
  • Glass: Stemmed Glass
  • Garnish: Mint Sprig

Bybit Report: Gold Set to Surpass $3,000 in 2025

DUBAI, UAE, March 3, 2025 /PRNewswire/ — Bybit, the world’s second-largest cryptocurrency exchange by trading volume, has released its latest Bybit Commodity Insight Report. The report provides key insights into the macroeconomic and geopolitical trends driving gold’s bullish trajectory, analyzing the factors that could push the precious metal to new all-time highs.

Key Highlights:

  • Bullish Outlook: Gold is expected to surpass $3,000 per ounce in 2025, supported by strong macroeconomic and geopolitical factors.
  • Inflation Hedge: Persistent inflation above the Federal Reserve’s target strengthens gold’s role as a hedge against currency devaluation.
  • Monetary Policy Shifts: Anticipated U.S. interest rate cuts could boost gold’s appeal over interest-bearing assets.
  • Geopolitical Tensions: Global conflicts, including U.S.-China tensions and the RussiaUkraine war, are driving demand for safe-haven assets.
  • Central Bank Demand: Record-breaking gold purchases, especially by China and Russia, provide structural support for higher prices.
  • Technical Momentum: Breaking past $3,000 could accelerate gains toward $3,200–$3,500.
  • Investor Confidence: Strong ETF inflows and speculative positioning signal a bullish market sentiment.

Macroeconomic Drivers

With inflation projected to remain above 2%, gold continues to serve as a hedge against declining purchasing power. The Federal Reserve’s expected rate cuts could further increase demand, as lower real interest rates make gold more attractive than fixed-income assets.

Sources: International Monetary Fund (IMF) Global Economic Outlook, 2025; U.S. Bureau of Labor Statistics (BLS); European Central Bank (ECB); World Bank Macroeconomic Indicators
Sources: International Monetary Fund (IMF) Global Economic Outlook, 2025; U.S. Bureau of Labor Statistics (BLS); European Central Bank (ECB); World Bank Macroeconomic Indicators

Geopolitical Uncertainty

Ongoing conflicts and global instability are reinforcing gold’s safe-haven appeal. Historically, gold has outperformed during periods of geopolitical stress, with investors turning to it as a hedge against uncertainty. The current environment suggests this trend will continue.

Central Bank Accumulation

Central banks purchased over 1,000 metric tons of gold in 2024, a trend expected to persist as countries like China and Russia diversify away from the U.S. dollar. This steady accumulation supports prices and limits downside risk.

Technical Strength & Market Sentiment

Gold remains in a strong uptrend, with key resistance levels in focus. A break above $3,000 could trigger further gains, while ETF inflows and rising futures positions indicate strong investor confidence.

Conclusion

Gold’s path to $3,000 is driven by inflation, central bank demand, geopolitical uncertainty, and positive technical indicators. As global instability persists, gold’s status as a safe-haven asset is expected to strengthen.

For a deeper analysis of these trends, access the full Bybit Commodity Insight Report from Bybit.

#Bybit / #TheCryptoArk /#BybitResearch/#BybitLearn

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving a global community of over 60 million users. Founded in 2018, Bybit is redefining openness in the decentralized world by creating a simpler, open and equal ecosystem for everyone. With a strong focus on Web3, Bybit partners strategically with leading blockchain protocols to provide robust infrastructure and drive on-chain innovation. Renowned for its secure custody, diverse marketplaces, intuitive user experience, and advanced blockchain tools, Bybit bridges the gap between TradFi and DeFi, empowering builders, creators, and enthusiasts to unlock the full potential of Web3. Discover the future of decentralized finance at Bybit.com.

For more details about Bybit, please visit Bybit Press
For media inquiries, please contact: media@bybit.com  
For updates, please follow: Bybit’s Communities and Social Media

Discord | Facebook | Instagram | LinkedIn | Reddit | Telegram | TikTok | X | Youtube

 

‘Western waistlines’ on the way globally as supermarkets and convenience stores take over the world, new study warns

Immediate action needed to disrupt junk food diet trend

Some of the fastest growing countries in the world are set for dietary disaster as the trend of convenience store and supermarket dominance takes hold, according to a new global study released today on World Obesity Day.

MELBOURNE, AUSTRALIA – Media OutReach Newswire – 4 March 2025 – Just published in Nature Food, the study by researchers from Deakin University in Australia and experts from UNICEF, unveils a seismic shift in the types of food stores springing up globally over the past 15 years, with serious health implications for vulnerable low and middle-income countries.

Analysing data from 97 countries on retail changes over the last 15 years, the study showed that the number of chain supermarkets, hypermarkets and convenience stores per 10,000 people increased by 23.6% globally over the period. With market domination by these types of retailers being the norm in high-income countries, low and middle-income countries are copying the trend and catching up fast. In South Asia and Southeast Asia, the number of chain retail outlets per person has increased by nearly 10% per year, with a corresponding drop off in independently owned traditional stores.

And in a sign that retail is set for an even bigger shake up, grocery sales from digital retailers increased by 325% over a 10-year period across 27 countries.

In a clear indication that more supermarkets and convenience stores are bad for our health, the researchers showed for the first time that at a global scale, change in the density of chain retail outlets and the increasing amount of unhealthy food sold by them was associated with an increase in the prevalence of obesity, which continues to rise in every region of the world and is very much a global concern.

And how does the increase in the number of chain retailers impact our health?

According to the study’s lead author Dr Tailane Scapin, from Deakin University:

“Large chain retailers usually hold significant market power, using their dominance over food manufacturers to determine what food is available and what price it’s sold at, which has led to the widespread availability of unhealthy foods.

“Large chain retailers and food manufacturers also use aggressive marketing strategies to promote unhealthy foods, contributing to poor dietary habits and, as consequence, negatively impacting their customers’ health.”

Dr Scapin said that immediate action was needed to address the impact of changing retail food environments.

“Our findings underscore the importance of regulating the retail environment to make sure that it’s healthy foods that are promoted, while the marketing and promotion of unhealthy food products is limited.

“In low and middle-income countries where supermarkets and convenience stores are spreading the fastest, governments have a time-limited opportunity to make sure that these new, modern retail stores actually promote healthy food. We know from the experience in North America, Europe and other high-income regions that once retailers are established, they are very hard to change.”

The study’s research team called for urgent action from governments, from retailers and from the health promotion workforce to prioritise healthier retail food environments that support sustainable and healthy dietary patterns and positive public health outcomes.

“With this research published on World Obesity Day which has a theme of ‘Changing systems for healthier lives’, it’s important that the promising action being taken by forward-thinking retailers and governments is scaled up globally,” Dr Scapin said.

The full study report, with data by country, by geographic region and by country income group, appears in the publication in Nature Food and in an interactive dashboard here.

This work was completed as part of a collaboration between UNICEF and the Centre of Research Excellence in Food Retail Environments for Health: Next Generation in Australia.

For further information visit: healthyfoodretail.com

Hashtag: #healthyfoodretail #globalhealth #healthyfoodresearch #research #WorldObesityDay #WOD #DeakinUniversity #GLOBE #populationhealth


The issuer is solely responsible for the content of this announcement.

Global Centre for Preventive Health and Nutrition, Deakin University, Australia

) at Deakin University in Australia is a designated World Health Organisation Collaborating Centre for Obesity Prevention. GLOBE’s vision is to catalyse improvements in population health – with a focus on prevention, nutrition and obesity – through innovative research that empowers people and enables healthier environments.
GLOBE is one of the largest research groups dedicated to obesity prevention research in Australia. As a leader in preventive health and nutrition research, our methods are drawn from multiple disciplines, including public health, nutrition and dietetics, epidemiology, political science, health economics, systems science and implementation science.
GLOBE is part of Deakin University’s Institute for Health Transformation.

HONOR Announces 7 Years of Android OS and Security Updates for the HONOR Magic Series

Extended support allows flagship devices to maintain access to the latest AI innovation and stay secure for longer

BARCELONA, Spain, March 3, 2025 /PRNewswire/ — Global technology brand HONOR today announced that it will begin offering seven years of Android OS and security updates for its flagship HONOR Magic series[1], starting in EU markets.


Announced as part of the HONOR ALPHA PLAN, the pledge attests to HONOR’s commitment to putting customers first, and makes the brand one of three in the industry today to provide consumers with this extended coverage. HONOR hopes the change would inspire industry peers to replicate for their customers, allowing more to take advantage of the latest innovation while improving security for all smartphone device users worldwide.

“The HONOR ALHPA PLAN has a strong emphasis on a consumer-centric approach to our future products. We aim to provide devices and services that meet consumer needs and beyond their expectation now and in the future. Therefore, HONOR has decided to offer seven years of Android OS and security updates to the HONOR Magic series. This includes our flagship bar phone and foldable phone. This commitment begins with the HONOR Magic7 Pro. We are delighted to make this available to our customers,” said James Li, CEO of HONOR.

The HONOR ALPHA PLAN is a new corporate strategy to transform HONOR from a smartphone maker to a global leading AI device ecosystem company. The visionary three-step plan details the bold steps HONOR will take to usher in the new intelligent world, and calls on the industry to co-create an open, value-sharing ecosystem that maximizes human potential, ultimately benefiting all mankind.

The extended support not only extends the lifespan of devices and reduces e-waste, in line with the sustainability standards, but also ensures users enjoy secure, high-performing devices with the latest AI technology throughout their extended lifecycles.

HONOR Magic7 Pro users in the EU are the first to benefit from the support extension. In the future, HONOR will offer the extended support to more flagship models, including bar phones and foldable phones.

[1] This support does not apply to HONOR Magic Lite series devices.

 

Acurx Announces Publication of Nonclinical In Vivo Data Differentiating Ibezapolstat’s Gut Microbiome Effects from Other Anti-CDI Antibiotics

  • First ever head-to-head comparison of gut microbiome changes associated with ibezapolstat (IBZ) to other anti-CDI antibiotics in a germ-free mouse model
  • Changes in alpha and beta microbiome diversities following IBZ treatment were less pronounced compared to those observed in vancomycin (VAN)-or metronidazole (MET)-treated groups, complementing prior Phase 2 clinical findings showing IBZ’s more selective antibacterial activity
  • Notable differences were observed between the microbiome of IBZ- and fidaxomicin (FDX)-treated groups, which may allow for differentiation of these two anti-CDI antibiotics in future studies
  • Results establish IBZ differentiating effects on the gut microbiome, indicating a more selective spectrum of microbiome alteration compared to broader-spectrum antibiotics like VAN and MET and a narrower spectrum of microbiome alteration compared to FDX
  • Preparation continues to advance IBZ into international Ph3 clinical trials for treatment of CDI
  • IBZ has previously been granted FDA QIDP and Fast-Track Designation and has received SME (Small and Medium-sized Enterprise) designation by the EMA

STATEN ISLAND, N.Y., March 3, 2025 /PRNewswire/ — Acurx Pharmaceuticals, Inc. (NASDAQ: ACXP) (“Acurx” or the “Company”) is a late-stage biopharmaceutical company developing a new class of small molecule antibiotics for difficult-to-treat bacterial infections, with its lead antibiotic candidate, ibezapolstat, preparing to advance to international Phase 3 clinical trials to treat patients with C. difficile Infection (CDI). The Company today announced the results of a study in a humanized mouse model and its publication in the Journal of Antimicrobial Agents and Chemotherapeutics entitled: “Microbiome impact of ibezapolstat and other Clostridioides difficile infection-relevant antibiotics using humanized mice”. The primary author is Trenton Wolfe, a PhD student at the University of Montana. This study was funded by the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI), National Center for Advancing Translational Sciences (NCATS), and the Company.

According to co-author Kevin Garey, PharmD, MS, FIDSA, Professor and Chair, University of Houston College of Pharmacy, Principal Investigator for microbiology and microbiome aspects of the ibezapolstat clinical trial program, and Acurx Scientific Advisory Board member: “This study provides critical evidence to begin to distinguish ibezapolstat from other C. difficile directed antibiotics, especially fidaxomicin. Although both ibezapolstat and fidaxomicin were narrower spectrum than vancomycin or metronidazole, ibezapolstat’s effect on the microbiome was distinctly different than fidaxomicin. How this translates into beneficial health effects or emergence of antimicrobial resistance will be an area of further study.”

Acurx’s Executive Chairman, Bob DeLuccia, stated: “These results of this first ever direct comparison of the gut microbiome effects of ibezapolstat in a validated humanized mouse model set the stage for potential competitive advantage of IBZ over all commonly used anti-CDI antibiotics, including fidaxomicin”. He added: “These data also serve as a foundation upon which to build future planned preclinical and clinical studies at the appropriate time to further clarify ibezapolstat’s favorable effect on the microbiome known to confer health benefits to patients with CDI.”

This study was a head-to-head comparison of intestinal microbiome effects of IBZ with other CDI antibiotics and has not been done previously in non-clinical, in vivo models. The purpose of this study was to compare gut microbiome changes associated with IBZ to other anti-CDI antibiotics in groups of germ-free mice. Changes in alpha and beta microbiome diversities following IBZ treatment were less pronounced compared to those observed in VAN- or MET-treated groups. By the end of therapy, IBZ increased the relative abundance of Bacteroidota and Actinomycetota phyla. In microbiome-humanized mice, IBZ and FDX had smaller effects on gut microbiome diversity, a positive outcome, compared to VAN and MET. This analysis places IBZ in a similar category of microbiome disruption as FDX with notable favorable differences of IBZ over FDX and indicating a narrower spectrum of microbiome alteration compared to broader-spectrum agents like VAN and MET. However, notable differences were observed between the microbiome of IBZ- and FDX-treated groups, which may allow for differentiation of these two antibiotics in future studies, such as increased proportion of Actinomycetota bacteria which include Bifidobacteria and other species known to confer human health benefits.

THE PUBLICATION IS ON OUR WEBSITE: www.acurxpharma.com

About the AAC Journal:
Antimicrobial Agents and Chemotherapy (AAC) is an interdisciplinary journal devoted to the dissemination of knowledge relating to all aspects of antimicrobial and antiparasitic agents and chemotherapy. Generally, any report involving studies on or with antimicrobial, antiviral (including antiretroviral), or antiparasitic agents is within the purview of AAC. Studies involving animal models, pharmacological characterization, and clinical trials are appropriate for consideration.

 Acurx previously announced that it had received positive regulatory guidance from the EMA during its Scientific Advice Procedure which confirmed that the clinical, non-clinical and CMC (Chemistry Manufacturing and Controls) information package submitted to EMA supports advancement of the ibezapolstat Phase 3 program and if the Phase 3 program is successful, supports the submission of a Marketing Authorization Application (MAA) for regulatory approval in Europe.  The information package submitted to EMA by the Company to which agreement has been reached with EMA included details on Acurx’s two planned international Phase 3 clinical trials, 1:1 randomized (designed as non-inferiority vs vancomycin), primary and secondary endpoints, sample size, statistical analysis plan and the overall registration safety database. With mutually consistent feedback from both EMA and FDA, Acurx is well positioned to commence our international Phase 3 registration program.

The primary efficacy analysis will be performed using a Modified Intent-To-Treat (mITT) population. This will result in an estimated 450 subjects in the mITT population, randomized in a 1:1 ratio to either ibezapolstat or standard- of-care vancomycin, enrolled into the initial Phase 3 trial. The trial design not only allows determination of ibezapolstat’s ability to achieve Clinical Cure of CDI as measured 2 days after 10 days of oral treatment, but also includes assessment of ibezapolstat’s potential effect on reduction of CDI recurrence in the target population. In the event non-inferiority of ibezapolstat to vancomycin is demonstrated, further analysis will be conducted to test for superiority.

About the Ibezapolstat Phase 2 Clinical Trial
The completed multicenter, open-label single-arm segment (Phase 2a) study was followed by a double-blind, randomized, active-controlled, non-inferiority, segment (Phase 2bat 28 US clinical trial sites which together comprise the Phase 2 clinical trial. (Link

to Clinicaltrials.gov/NCT042447542) This Phase 2 clinical trial was designed to evaluate the clinical efficacy of ibezapolstat in the treatment of CDI including pharmacokinetics and microbiome changes from baseline. from study centers in the United States. In the Phase 2a trial segment,10 patients with diarrhea caused by C. difficile were treated with ibezapolstat 450 mg orally, twice daily for 10 days. All patients were followed for recurrence for 28± 2 days. Per protocol, after 10 patients of the projected 20 Phase 2a patients completed treatment (100% cured infection at End of Treatment).

In the Phase 2b trial segment, which was discontinued due to success, 32 patients with CDI were enrolled and randomized in a 1:1 ratio to either ibezapolstat 450 mg every 12 hours or vancomycin 125 mg orally every 6 hours, in each case, for 10 days and followed for 28 ± 2 days following the end of treatment for recurrence of CDI. The two treatments were identical in appearance, dosing times, and number of capsules administered to maintain the blind.

The Company previously reported that the overall observed Clinical Cure rate in the combined Phase 2 trials in patients with CDI was 96% (25 out of 26 patients), based on 10 out of 10 patients (100%) in Phase 2a in the Modified Intent to Treat Population, plus 15 out of 16 (94%) patients in Phase 2b in the Per Protocol Population, who experienced Clinical Cure during treatment with ibezapolstat. 

100% (25 of 25) ibezapolstat-treated patients in Phase 2 (Phase 2a and 2b) who had Clinical Cure at EOT) (End of Treatment) remained cured through one month after EOT, as compared to 86% (12 of 14) for the vancomycin patient group.  Ibezapolstat was well-tolerated, with three patients each  experiencing one mild adverse event assessed by the blinded investigator to be drug- related. All three events were gastrointestinal in nature and resolved without treatment. There were no drug-related treatment withdrawals or no drug-related serious adverse events, or other safety findings of concern. In the Phase 2b vancomycin control arm, 14 out of 14 patients experienced Clinical Cure. The Company is confident that based on the pooled Phase 2 ibezapolstat Clinical Cure rate of 96% and the historical vancomycin cure rate of approximately 81% (Vancocin® Prescribing Information, January 2021), we will demonstrate non-inferiority of ibezapolstat to vancomycin in Phase 3 trials in accordance with the applicable FDA Guidance for Industry (October 2022).

In the Phase 2 clinical trial (both trial segments), the Company also evaluated pharmacokinetics (PK) and microbiome changes and test for anti-recurrence microbiome properties, including the change from baseline in alpha diversity and bacterial abundance, especially overgrowth of healthy gut microbiota Actinobacteria and Firmicute phylum species during and after therapy. Phase 2a data demonstrated complete eradication of colonic C. difficile by day three of treatment with ibezapolstat as well as the observed overgrowth of healthy gut microbiota, Actinobacteria and Firmicute phyla species, during and after therapy. Very importantly, emerging data show an increased concentration of secondary bile acids during and following ibezapolstat therapy which is known to correlate with colonization resistance against C. difficile. A decrease in primary bile acids and the favorable increase in the ratio of secondary-to-primary bile acids suggest that ibezapolstat may reduce the likelihood of CDI recurrence when compared to vancomycin. The company also recently reported positive extended clinical cure (ECC) data for ibezapolstat (IBZ), its lead antibiotic candidate, from the Company’s recently completed Phase 2b clinical trial in patients with CDI. This exploratory endpoint showed that 12 patients who agreed to be followed up to three months following Clinical Cure of their infection, 5 of 5 IBZ patients experienced no recurrence of infection. In the vancomycin control arm of the trial, 7 of 7 patients experienced no recurrence of infection. ECC success is defined as a clinical cure at the TOC visit (i.e., at least 48 hours post EOT) and no recurrence of CDI within the 56 ± 2 days post EOT (ECC56) and 84 ± 2 days post EOT (ECC84) in patients who consented to extended observation. In the Phase 2b trial, 100% (5 of 5) of ibezapolstat-treated patients who agreed to observation for up to three months following Clinical Cure of CDI experienced no recurrence of infection. Furthermore, ibezapolstat-treated patients showed lower concentrations of fecal primary bile acids, and higher beneficial ratio of secondary to primary bile acids than vancomycin-treated patients.

About Ibezapolstat
Ibezapolstat is the Company’s lead antibiotic candidate planning to advance to international Phase 3 clinical trials to treat patients with C. difficile Infection (CDI). Ibezapolstat is a novel, orally administered antibiotic, being developed as a Gram-Positive Selective Spectrum (GPSS®) antibacterial. It is the first of a new class of DNA polymerase IIIC inhibitors under development by Acurx to treat bacterial infections. Ibezapolstat’s unique spectrum of activity, which includes C. difficile but spares other Firmicutes and the importantActinobacteria phyla, appears to contribute to the maintenance of a healthy gut microbiome.

In June 2018, ibezapolstat was designated by the U.S. Food and Drug Administration (FDA) as a Qualified Infectious Disease Product (QIDP) for the treatment of patients with CDI and will be eligible to benefit from the incentives for the development of

new antibiotics established under the Generating New Antibiotic Incentives Now (GAIN) Act. In 2019, FDA granted “Fast Track” designation to ibezapolstat for the treatment of patients with CDI. The CDC has designated C. difficile as an urgent threat highlighting the need for new antibiotics to treat CDI.

About Clostridioides difficile Infection (CDI)
According to the 2017 Update (published February 2018) of the Clinical Practice Guidelines for C. difficile Infection by the Infectious Diseases Society of America (IDSA) and Society or Healthcare Epidemiology of America (SHEA), CDI remains a significant medical problem in hospitals, in long-term care facilities and in the community. C. difficile is one of the most common causes of health care- associated infections in U.S. hospitals (Lessa, et al, 2015,

New England Journal of Medicine). Recent estimates suggest C. difficile approaches 500,000 infections annually in the U.S. and is associated with approximately 20,000 deaths annually. (Guh, 2020, New England Journal of Medicine). Based on internal estimates, the recurrence rate for the antibiotics currently used to treat CDI is between 20% and 40% among approximately 150,000 patients treated. We believe the annual incidence of CDI in the U.S. approaches 600,000 infections and a mortality rate of approximately 9.3%.

About the Microbiome in C. difficile Infection (CDI) and Bile Acid Metabolism
C. difficile can be a normal component of the healthy gut microbiome, but when the microbiome is thrown out of balance, the C. difficile can thrive and cause an infection. After colonization with C. difficile, the organism produces and releases the main virulence factors, the two large clostridial toxins A (TcdA) and B (TcdB). (Kachrimanidou, Microorganisms 2020, 8, 200; doi:10.3390/microorganisms8020200.) TcdA and TcdB are exotoxins that bind to human intestinal epithelial cells and are responsible for inflammation, fluid and mucous secretion, as well as damage to the intestinal mucosa. Bile acids perform many functional roles in the GI tract, with one of the most important being maintenance of a healthy microbiome by inhibiting C. difficile growth. Primary bile acids, which are secreted by the liver into the intestines, promote germination of C. difficile spores and thereby

increase the risk of recurrent CDI after successful treatment of an initial episode. On the other hand, secondary bile acids, which are produced by normal gut microbiota through metabolism of primary bile acids, do not induce C. difficile sporulation and therefore protect against recurrent disease. Since ibezapolstat treatment leads to minimal disruption of the gut microbiome, bacterial production of secondary bile acids continues which may contribute to an anti-recurrence effect. Beneficial effects of bile acids include a decrease in primary bile acids and an increase in secondary bile acids in patients with CDI, which was observed in the Company’s Ph2a trial results and previously reported (CID, 2022). In the Ph2b trial, ibezapolstat-treated patients showed lower concentrations of fecal primary bile acids, and higher beneficial ratio of secondary to primary bile acids than vancomycin-treated patients.

About Acurx Pharmaceuticals, Inc.
Acurx Pharmaceuticals is a late-stage biopharmaceutical company focused on developing a new class of small molecule antibiotics for difficult-to-

treat bacterial infections. The Company’s approach is to develop antibiotic candidates with a Gram-positive selective spectrum (GPSS®) that blocks the active site of the Gram-positive specific bacterial enzyme DNA polymerase IIIC (pol IIIC), inhibiting DNA replication and leading to Gram-positive bacterial cell death. Its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, methicillin- resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE), drug- resistant Streptococcus pneumoniae (DRSP) and B. anthracis (anthrax; a Bioterrorism Category A Threat-Level pathogen). Acurx’s lead product candidate, ibezapolstat, for the treatment of C. difficile Infection is Phase 3 ready with plans in progress to begin international clinical trials next year. The Company’s preclinical pipeline includes development of an oral product candidate for treatment of ABSSSI (Acute Bacterial Skin and Skin Structure Infections), upon which a development program for treatment of inhaled anthrax is being planned in parallel.

To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com.

Forward-Looking Statements
Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words “believes,” “anticipates,” “plans,” “expects,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether ibezapolstat will benefit from the QIDP designation; whether ibezapolstat will advance through the clinical trial process on a timely basis; whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the FDA or equivalent foreign regulatory agencies where approval is sought; whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed; and other risks and uncertainties described in the Company’s annual report filed with the Securities and Exchange Commission on Form 10-K for the year ended December 31, 2023, and in the Company’s subsequent filings with the Securities and Exchange Commission. Such forward- looking statements speak only as of the date of this press release, and Acurx disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances after the date of such statements, except as may be required by law.

Investor Contact:
Acurx Pharmaceuticals, Inc.
David P. Luci, President & CEO
Tel: 917-533-1469

Email: davidluci@acurxpharma.com