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Ascletis Announces China National Medical Products Administration Acceptance of New Drug Application for Denifanstat (ASC40), a First-in-Class FASN Inhibitor for Acne Treatment

-Denifanstat (ASC40) met all primary, key secondary and secondary efficacy endpoints (ITT analysis) and significantly improved moderate-to-severe acne vulgaris compared with placebo in a randomized, double-blind, placebo-controlled, multicenter Phase III clinical trial.

HONG KONG, Dec. 10, 2025 /PRNewswire/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces today that its New Drug Application (NDA) for denifanstat (ASC40), a first-in-class, once-daily oral small molecule fatty acid synthase (FASN) inhibitor for the treatment of moderate-to-severe acne vulgaris, has been accepted by the China National Medical Products Administration (NMPA).

“Acceptance of this NDA is an important milestone in our efforts to provide a potentially groundbreaking therapeutic approach for the treatment of moderate-to-severe acne,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, “We are excited denifanstat (ASC40) is only one step away from the commercialization.”

Ascletis has completed Phase II (NCT05104125) and Phase III (NCT06192264) studies of denifanstat (ASC40) for the treatment of moderate-to-severe acne vulgaris.

In the Phase III study, denifanstat (ASC40) met all primary, key secondary and secondary efficacy endpoints (ITT analysis) and significantly improved moderate-to-severe acne vulgaris compared with placebo. Denifanstat (ASC40) demonstrated a favorable safety and tolerability profile. All denifanstat (ASC40)-related treatment-emergent adverse events (TEAEs) were mild (Grade 1) or moderate (Grade 2). There were no denifanstat (ASC40)-related Grade 3 or 4 TEAEs and no denifanstat (ASC40)-related serious adverse events (SAEs). There were no denifanstat (ASC40)-related permanent treatment discontinuations or withdrawals observed.

The Phase III study results were presented as an oral presentation at the European Academy of Dermatology and Venereology (EADV) Congress 2025 in Paris, France on September 17, 2025 (link).

The Company recently completed the pre-NDA consultation with the China NMPA for denifanstat (ASC40) for the treatment of moderate-to-severe acne vulgaris and received positive feedback from NMPA.

Ascletis licensed denifanstat (ASC40) from Sagimet Biosciences Inc. (Nasdaq: SGMT) for exclusive rights in Greater China.

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a small molecule GLP-1R agonist designed to be administered once daily orally and once monthly to once quarterly subcutaneously as a treatment therapy and a maintenance therapy for chronic weight management; ASC36, a once-monthly subcutaneously administered amylin receptor peptide agonist, ASC35, a once-monthly subcutaneously administered GLP-1R/GIPR dual peptide agonist and ASC37, an oral GLP-1R/GIPR/GCGR triple peptide agonist for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

For more information, please visit www.ascletis.com.

Contact:

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com 

Ascletis Pharma Inc. PR and IR teams
+86-181-0650-9129 (China)
pr@ascletis.com
ir@ascletis.com 

THE HONEST FARMER Co. Ltd Prepares Entry Into Vietnam’s Online Market With Healthy K-Snack Offering

SEOUL, South Korea, Dec. 10, 2025 /PRNewswire/ — Korean grain snack producer THE HONEST FARMER Co. Ltd announced plans to expand its presence in Vietnam’s fast-growing e-commerce sector with the launch of its Black Barley & Brown Rice Chips. As internet and mobile shopping penetration rises in Vietnam, demand for healthy snack options via online marketplaces is also increasing.

THE HONEST FARMER Co. Ltd has completed applications to enter major Vietnamese online malls in partnership with a local distributor. The company is currently finalizing Vietnamese-language labeling for product packaging, while product detail pages will highlight key information such as raw ingredients, nutrition facts, zero-additive and low-calorie attributes, and HACCP-certified manufacturing processes—aimed at reinforcing transparency and consumer trust.

The move into online channels aligns with broader social trends in Vietnam, including the growth of single-person households, nuclear families, and the rising preference for convenient, ready-to-eat foods. Entering online marketplaces is viewed as an efficient route to deliver products directly to consumers without relying on traditional retail networks.

THE HONEST FARMER Co. Ltd also plans to monitor consumer response and may consider developing localized flavors—such as lightly salted or spiced versions—tailored to Vietnamese tastes and consumption habits.

A company representative stated, “Vietnamese consumers place strong emphasis on health and safety, even when choosing snacks. With zero trans fat, sodium, and sugar, our Black Barley & Brown Rice Chips are well-positioned to establish themselves as a trusted healthy snack in the Vietnamese market.”

Berlin Heals Welcomes Rob ten Hoedt as New Chairman of the Board

ZUG, Switzerland, Dec. 10, 2025 /PRNewswire/ — Berlin Heals Holding AG (Zug, Switzerland) is pleased to announce the appointment of Rob ten Hoedt as the new Chairman of the Board of Directors.

“We are thrilled to welcome someone of Rob ten Hoedt’s caliber to the Board,” said Marko Bagaric, Co-founder and Member of the Board of Directors. “His global impact on healthcare systems and deep expertise in medical technology will positively affect our progress and give us even more momentum for the exciting year ahead.”

Rob ten Hoedt brings more than three decades of global leadership in the medical technology and healthcare sectors, most recently serving as Executive Vice President and President, Global Regions, at Medtronic. Prior to that, he held senior leadership roles at Medtronic SQDM, Vitatron, and Urologix. Rob holds a degree in Commercial Economy from the H.E.A.O. in the Netherlands and a Master’s in Marketing from NIMA Business School. He currently serves as Chairman of the Board of Directors at Medmix and Onward Medical and is a member of the board of Fagron International.

“I am very excited to join the Board of Directors at Berlin Heals Holding AG and to contribute to its revolutionary new therapy in Heart Failure. Together, we will strive to bring the life-changing benefits of the C-MIC device to patients worldwide. A thrilling time lies ahead, and it is an honor to be part of it,” said Mr. ten Hoedt.

“We are delighted to welcome Rob ten Hoedt as our new Chairman of the Board of Directors as we enter a pivotal year for Berlin Heals,” said John Brumfield, Chief Executive Officer of Berlin Heals Holding AG. “His knowledge, leadership experience, and genuine passion for innovation will play an instrumental role in shaping our strategy and driving further growth.”

About CMIC Therapy

Cardiac Microcurrent (C-MIC) Therapy is delivered via a fully implantable medical device that consists of two electrodes connected to an implantable generator that provides constant direct microcurrent across the diseased heart. This constant DC current reduces inflammation and reverse remodels the heart that has been shown in previous studies to improve cardiac function and reduce symptoms. The first generation required a minimally invasive surgical procedure where a cardiothoracic surgeon placed an electrode on the outside of the heart. The new Less Invasive approach can be implanted in a cardiac catheterization lab through a conscious sedation out-patient procedure by a Cardiologist.

About Heart Failure

Heart Failure is a condition where the heart is weakened and cannot meet the body’s demand for blood flow. Symptoms include shortness of breath, fatigue and palpitations limiting ability to perform daily activities. The progressive disease leads to high frequency of hospital admissions, poor clinical outcomes and high cost of care. Heart Failure is a Global Pandemic that affects over 64 Million people around the world. In the western world, 1 in 4 people will develop the disease in their lifetime. The Global cost of Heart Failure care is rising dramatically to an estimated $858Billion annually by 2050. The disease is a leading cause of death with worse mortality than cancer. There is currently no commercially available cure.

About Berlin Heals Holding AG

Berlin Heals Holding is developing a novel treatment to reverse remodel and recover from Heart Failure. After a successful First-In-Human study in 2019 followed by sustaining long-term results and a successful Randomized Controlled Trial completed in 2024, the company has been developing a new approach to implant the device less invasively in an outpatient cardiac cath lab procedure. The company is based in Zug, Switzerland with subsidiaries in Germany and the United States.

ZAKSIMLAB Expands Its Wellness Portfolio With Three New Fruit-Infused Kombuchas and Lemon Apple Cider Vinegar

SEOUL, South Korea, Dec. 10, 2025 /PRNewswire/ — Korean wellness beverage brand ZAKSIMLAB is accelerating its presence in the functional drink market with the launch of three new fruit-infused kombucha flavors and a refreshed Lemon Apple Cider Vinegar drink.

Under the slogan “Deliciously Healthy,” ZAKSIMLAB has built its identity around naturally fermented, clean-label functional drinks. Its signature kombucha line—which features probiotics from natural fermentation and a refreshing effervescence—continues to gain strong traction among consumers. The brand’s Apple Cider Vinegar series, made with a blend of apple vinegar and lemon, also maintains steady popularity for its light calories and bright, citrus-forward flavor.

The newly released flavors—Apple Mango Kombucha, Gold Kiwi Kombucha, and Lemon Apple Cider Vinegar—have received enthusiastic market response, boosting the brand’s growth momentum.

Apple Mango Kombucha combines sweet apple and mango to deliver a smooth, fruit-forward taste.

Gold Kiwi Kombucha pairs tangy gold kiwi with the added texture of chia seeds, enhancing both health appeal and mouthfeel.

Lemon Apple Cider Vinegar features a crisp lemon-lime profile that provides refreshing everyday condition care.

A ZAKSIMLAB official stated, “Fruit-based kombucha offers a healthy alternative to traditional carbonated drinks and juices,” adding, “We aim to deliver accessible and enjoyable wellness experiences that fit seamlessly into consumers’ daily routines.”

Dreame TV’s International Blitz: Next-Gen Mini LED Technology Storms Global Stage

SHENZHEN, China, Dec. 10, 2025 /PRNewswire/ — Dreame Technology is entering the global mini LED TV market with its Dreame TV series through Shenzhen Televi Intelligent Technology Co., Ltd., a technology enterprise under Dreame. After its debut at IFA Berlin and ELLE POP – UP in Hungary, it will also be exhibited at CES. Having been launched in Singapore and other countries, the series is planned for release in the United Arab Emirates in December, and Malaysia is also incorporated into the release scheme.

The Dreame TV S100 and V3000 series showcased the Aura Mini LED technology at the 138th Canton Fair, which was recently inaugurated. The S100 exhibited in November at Budapest’s premier ELLE POP-UP exhibition. S100 features Aura Mini LED backlight with full-array local dimming, delivering precise light control and deep blacks. With a peak brightness of 1000 nits and QLED+ technology producing over 1.07 billion colors, every detail is sharp and every shade true to life. Powered by the custom Dreamind™ Pro AI Processor, 2K content is intelligently upscaled close to 4K, with adaptive color and clarity tuning for natural, vivid frames.

At the same time, the S100 is integrated with the Dreame 4.1.2ch Master Sound System, equipped with 11 sound units covering high, mid, and low frequency ranges, delivering a more complete sound layer. The peak power reaches 70W, far higher than the typical 40W output of mainstream TVs, providing more ample soundstage energy. With 270° physical sound coverage, it creates an audio field that nearly envelops the entire space. The S100 features a fully integrated soundbar system, making the purchase of this television functionally equivalent to acquiring both a standalone TV and a separate soundbar.

Dreame’s global flagship V3000 features a “Black Crystal True Color Screen” with just 1.8% reflectivity, eliminating glare in bright environments. Its Aura Mini LED Premium Display combines QLED and Mini LED technologies, delivering 1 billion colors, 98% DCI-P3 coverage, ΔE≈0.7 color accuracy, and 2800 nits peak brightness.

Gaming performance excels with a 300Hz refresh rate, 5.3ms input lag, and support for VRR, ALLM, and AMD FreeSync™ Premium Pro. The integrated Dreame Master Sound System 2.1.2ch with Dolby Atmos® is equipped with a dedicated subwoofer and a dual – horn design. It generates a 270° physical sound coverage, as opposed to the ordinary 360 – degree surround sound adjusted by algorithms. We eagerly anticipate the launch of the V3000 in the United Arab Emirates, Singapore, and Indonesia.

Dreame TV has showcased its projectors and audio systems at IFA, with plans to exhibit at CES. The product line includes the T2 laser projector, offering 120-inch Full HD images with auto-correction and a battery-powered design, and the T3 ultra-short-throw model for large screens from a minimal distance.

Shenzhen Televi Intelligent Technology Co., Ltd. is a technology enterprise under Dreame, dedicated to advancing innovation in home audio-visual and display technologies.

Risen Energy Secures New Global Energy Storage Deal

NINGBO, China, Dec. 10, 2025 /PRNewswire/ — Recently, Risen Energy announced the signing of a 3 GWh energy storage system cooperation MOU with WEG, a leading Brazilian industrial giant. Pursuant to the MOU, Risen Energy will supply WEG with advanced utility-scale and commercial & industrial ESS from 2026 to 2028, supporting global energy structure optimization and the green, low-carbon transition.

Founded in 1961 and headquartered in Santa Catarina, Brazil, WEG is one of Latin America’s largest electrical equipment manufacturers, with operations spanning over 140 countries worldwide. The company has deep expertise in renewable energy, industrial energy efficiency, and smart grid technologies. In recent years, WEG has actively expanded into energy storage and integrated energy services, aiming to deliver efficient, reliable, and sustainable energy infrastructure across global markets.

Risen Storage has been dedicated to the lithium battery industry for 20 years, integrating R&D, manufacturing, sales, and services. Its products include PCS, BMS, EMS, C&I, and Utility-Scale ESS. Notably, its Energy Storage Battery System was the first in China to achieve UL9540A certification in both the U.S. and China. Through the deep integration of 4S technology, Risen Storage has developed self-engineered BESS solutions for all applications. These solutions are applicable in renewable energy integration, peak shaving, frequency regulation, demand response, backup power, microgrids, and other applications. The company remains committed to transforming the energy landscape through technological innovation.

This strategic partnership not only marks a critical step forward for Risen Energy and WEG in building next-generation power systems but also represents a truly global collaboration. Risen Energy will supply ESS for WEG’s projects across multiple regions—including South America, North America, Europe, Africa, and Australia—signaling an upgrade from regional cooperation to a comprehensive global strategic alignment. In fact, Risen Energy and WEG have a long-standing partnership in the photovoltaic sector. This expanded collaboration into energy storage underscores WEG’s renewed confidence in Risen Energy’s technical capabilities and global delivery track record.

From bringing stable electricity to remote villages in South America and lighting up thousands of households, to enabling energy transitions for industrial parks in North America; from supporting residential solar-plus-storage systems in Europe to empowering off-grid communities in Africa with green microgrids—Risen Energy’s business now spans more than 90 countries and regions worldwide. Moving forward, Risen Energy will continue to partner with WEG and other global collaborators, leveraging its safe, reliable, and fully in-house developed solar-plus-storage technologies to deploy green energy solutions across diverse regions and applications—accelerating the global transition toward a more efficient, resilient, and sustainable energy system.

An Income Strategy for Volatile Markets – CSOP HSCEI Covered Call Active ETF (2802.HK) Debuts on HKEX Tomorrow

HONG KONG, Dec. 10, 2025 /PRNewswire/ — CSOP HSCEI Covered Call Active ETF (2802.HK) will be listed on the Hong Kong Stock Exchange on 11 December 2025. 2802.HK seeks to achieve its investment objective by primarily (i) investing in constituent equity securities in the Hang Seng China Enterprises Index (HSCEI); and (ii) selling call options on HSCEI to receive call options premium. 2802.HK has a listing price of 8.8 HKD per unit, trading unit of 100, and management fee of 0.99%. An unlisted class is also available to investors.

CSOP HSCEI Covered Call Active ETF (2802.HK)
CSOP HSCEI Covered Call Active ETF (2802.HK)

CSOP HSCEI Covered Call Active ETF (2802.HK) targets monthly distributions generated by dividends from the underlying stocks on top of option premiums, making it appealing to income-focused investors seeking higher yields (Dividend rate is not guaranteed and may be paid out of the capital)[1]. Serving as a partial cushion against market downturns, option premiums can help reduce losses and portfolio volatility compared to just holding stocks. The HSCEI covered call strategy performs more resilient in a declining market compared to the HSCEI alone. For instance, between August 2023 and March 2024, the HSCEI covered call strategy returned 2.86%, while the HSCEI recorded a decline of 7.53%[2]. With strong derivatives experience managing US$8.6 billion in derivatives[3], CSOP Asset Management (CSOP) offers professional expertise, giving investors easy access to covered call strategies without the complexity of self-management.

A covered call strategy is an options trading strategy that involves holding a long position in a particular asset (for example, a stock, a commodity, a bond, a currency, or an index) while simultaneously writing call options on the same asset. Performance varies by market regime. The strategy tends to perform best in range‑bound markets, where premium income can provide more stable returns and assignment risk is lower. A bullish market scenario typically yields the lowest return for a covered call strategy. Call option exercise forces a cash payment or the liquidation of long-position assets. Upside is limited to the call option’s strike price plus the premium received. In bearish markets, the option premium offsets some losses from a market drop. However, the premium may not fully cover sharp market declines.

Ms. Ding Chen, CEO of CSOP states, “Since our establishment in 2008, CSOP has consistently sought to provide high quality, innovative investment tools to Asian investors. Today, we are proud to introduce the CSOP HSCEI Covered Call Active ETF (2802.HK), offering investors a new income‑generating solution that aims to deliver monthly distributions and enhance resilience in volatile markets.”

About CSOP Asset Management

For over a decade, CSOP has successfully established itself as one of the leading ETF issuers in Hong Kong, with second largest AUM and demonstrated innovative product development. As of 30 November 2025, the total AUM of CSOP reached 27.9 billion USD by building a healthy ETF ecosystem and managing 63 ETPs and 4 mutual funds in Hong Kong and Singapore markets*. In 2025, 6 out of the top 10 most actively traded ETPs in Hong Kong are managed by CSOP**.

*Source: CSOP

** Source: Bloomberg, from 2 January 2025 to 28 November 2025

Disclaimer and Important Notices

Investment involves risks. Investors should refer to the Prospectus and the Product Key Facts Statement for further details, including product features and the full list of risk factors. This material is prepared by CSOP Asset Management Limited and has not been reviewed by the Securities and Futures Commission in Hong Kong. Please read the detailed disclosure and disclaimer carefully by accessing website (https://www.csopasset.com/en/education/disclaimer_en_forCoveredCall.html).
Issuer: CSOP Asset Management Limited

[1] The Manager intends to declare and pay monthly dividends. However, there is neither a guarantee that such dividends will be made nor will there be a target level of dividend payout. The Manager may, at its discretion, pay dividend out of capital. Payments of dividends out of capital or effectively out of capital amounts to a return or withdrawal of part of an investor’s original investment or from any capital gains attributable to that original investment. Any distributions involving payment of dividends out of the Sub-Fund’s capital or effectively out of capital may result in an immediate reduction in the Net Asset Value per Unit of the Sub-Fund and will reduce any capital appreciation for the unitholders of the Sub-Fund.

[2] Source: Bloomberg, 2023/8/31-2024/3/28.

[3] Source: The notional amount of derivative (exchange traded futures, swap and listed option) in CSOP’s investment portfolio.

Matrixport Appoints Dominik Oggenfuss as Chief Executive Officer of Matrixport Asset Management AG

Seasoned finance leader to drive company’s next phase of growth and innovation

ZURICH, Dec. 10, 2025 /PRNewswire/ — Matrixport Group is pleased to announce the appointment of Dominik Oggenfuss as Chief Executive Officer of Matrixport Asset Management AG, effective today.

Dominik was previously a partner at Welsbach Holdings, bringing extensive experience in strategic advisory, venture and alternative investments. His expertise in business development and investor relations is complemented by executive education programs at Harvard Business School. With over 25 years of experience in the finance sector in Asia, Middle East and Europe, Dominik will lead the company’s strategic growth initiatives in Switzerland, oversee investment operations, and drive innovation across the rapidly evolving digital asset and traditional finance landscape.

“With our Swiss asset management platform in place, Matrixport Asset Management is entering its next phase focused on scaling an institution-grade business across Europe. Dominik’s appointment reflects our priorities in strengthening investment capabilities and building a long-term presence in key European markets.” said John Ge, CEO of Matrixport Group.

“I am honored to join Matrixport Asset Management AG as CEO and I look forward to working with the talented team. Being part of Matrixport Group, a global digital asset player in Asia, I am convinced we can deliver innovative investment solutions, strengthen client relationships, and expand Matrixport Group’s presence in both traditional and digital asset markets in Switzerland and beyond.” said Dominik Oggenfuss.

Other Key Personnel Appointments

Friedrich Herzog will be appointed Chief Investment Officer. Previously serving as Head of Research and Senior Portfolio Manager, Friedrich brings over a decade of expertise in managing both quantitative and discretionary strategies across multiple asset classes, complemented by strong technical and cross-asset experience. He has held positions at leading firms including Goldman Sachs and Omers Capital in New York, US. In his new role, Friedrich will continue to lead portfolio management and investment research, further advancing the company’s standing in the sector.

Hui Wang will assume responsibility as Chief Operating Officer in addition to her current position as Chief Compliance Officer. Hui will oversee operations, technology, risk and compliance. Joined Matrixport Group in 2019, Hui previously worked as Senior Compliance Officer at UBS, Credit Suisse, and Bank Julius Baer, brings extensive experience in operational leadership and regulatory compliance.

Recent Strategic Milestone: Expansion into Europe

In 2024, Matrixport expanded into the European crypto asset management market through its 100% acquisition of licensed Swiss manager Crypto Finance (Asset Management) AG. Following the all-cash acquisition, the firm was renamed Matrixport Asset Management AG, providing the Group with institutional-grade capabilities, FINMA-authorized asset management, and enhanced reach into key European markets under applicable regulatory regimes.

About Matrixport Asset Management AG

Matrixport Asset Management AG is a FINMA-authorized Manager of Collective Investment, bridging traditional finance with the digital asset ecosystem. The firm offers a comprehensive suite of regulated products, including funds, ETPs, AMCs, and discretionary asset management, providing institutional-grade security and compliant products for its clients.

About Matrixport

Founded in 2019, Matrixport is a global leading one-stop digital asset financial services platform that bridges traditional finance with the digital asset ecosystem through technology and regulatory compliance. The company has grown into a unicorn with a valuation exceeding US$1 billion and has established a licensed and regulated presence across major financial centres, including Singapore, Hong Kong, Switzerland, the United Kingdom, and the United States. With seven offices worldwide, Matrixport manages more than US$7 billion in assets, facilitates monthly trading volumes exceeding US$7 billion, with cumulative interest payments surpassing US$2 billion. Its platform offers a comprehensive range of digital financial services including custody, wealth and yield management, structured products, and trading solutions for global clients.

Guided by the principles of compliance, resilience, technology-driven innovation, and security, Matrixport has built a robust global compliance framework and a multi-layered risk management and security infrastructure, supported by a worldwide licensing footprint. As a Group, and through its local subsidiaries, Matrixport holds a Hong Kong Trust Company License and Money Lender License, a U.S. Money Services Business (MSB) registration, a Swiss FINMA asset management license, and a Financial Services Licence (FSL) in Bhutan. It is also an FCA-authorised appointed representative in the United Kingdom and a member of Switzerland’s FINMA-recognised SRO-VFQ, while its subsidiary, Fly Wing, is licensed as a Major Payment Institution in Singapore. Upholding its mission to “make global assets safer and more accessible,” Matrixport continues to advance the global development of digital financial infrastructure and has been recognised on the Hurun “2024 Global Unicorn Index” and the “2025 Singapore FinTech Unicorn List.”