HONG KONG, Dec. 7, 2025 /PRNewswire/ — Akeso, Inc. (9926.HK) (“Akeso” or the “Company”) announced the successful inclusion of all five of the Company’s self-developed innovative drugs into the updated National Reimbursement Drug List (NRDL) for 2025, released by China’s National Healthcare Security Administration (NHSA), effective January 1, 2026.  These inclusions cover both newly added indications of previously included drugs, and as well as those participating in national reimbursement negotiations for the first time. With these inclusions, all approved indications for Akeso’s five independently commercialized, internally developed drugs are now part of the NRDL.

Dr. Yu Xia, Founder, Chairwoman, President, and CEO of Akeso, said: “We are truly delighted to witness that all approved indications of the company’s five self-developed innovative drugs have been successfully included in the National Reimbursement Drug List (NRDL). The inclusion of these drugs—which address major tumor diseases with the highest incidence rates in China, such as lung cancer, gastric cancer, cervical cancer, and nasopharyngeal cancer, as well as metabolic and autoimmune disorders like hypercholesterolemia and psoriasis—enables Chinese patients to be among the first in the world to benefit from optimal treatment options. This achievement reduces the financial burden on patients and provides superior alternatives for tackling significant public health challenges. Notably, even prior to their inclusion in the NRDL, these drugs had already gained extensive and profound recognition from hospitals, physicians, and patients in real-world clinical practice, thanks to their breakthrough clinical value. The successful entry of multiple indications of these five products into the NRDL will further enhance end-users’ awareness and trust in the company’s innovative drugs, lay a solid foundation for accelerating their broader clinical adoption, propel Akeso’s commercialization of innovative drugs into a phase of sustained, rapid, and high-quality development, and strengthen the groundwork for the company’s deepened global expansion.

Akeso remains patient-centric and clinical value-driven, committed to developing more breakthrough therapies so that patients worldwide can benefit from novel treatments. This has always been the original intent of our drug innovation, and it is what we take pride in.”

Ivonescimab: All 1L and 2L NSCLC Indications Now Covered by NRDL

Akeso’s first-in-class PD-1/VEGF bispecific antibody, ivonescimab, has successfully secured the inclusion of its new first-line indication for PD-L1-positive non-small cell lung cancer (NSCLC) in the NRDL. In a Phase III head-to-head clinical trial, ivonescimab demonstrated compelling results, reducing the risk of disease progression or death by 49% compared to pembrolizumab. Notably, ivonescimab is the first drug globally to show significantly superior efficacy over pembrolizumab in a Phase III trial. This breakthrough clinical value has been widely recognized by global academic and biopharma communities, as well as expert evaluators during this year’s NRDL negotiation. Ivonescimab for the treatment of EGFR-TKI resistant NSCLC was already included in the NRDL in 2024.

Cadonilimab: All 1L Gastric Cancer, 1L Cervical Cancer, and 2L/3L Cervical Cancer Indications Now Covered by NRDL

Akeso’s first-in-class PD-1/CTLA-4 bispecific antibody, cadonilimab, has successfully negotiated the inclusion of its new first-line gastric cancer and first-line cervical cancer indications into the NRDL. Cadonilimab is the only immuno-oncology drug globally to demonstrate significant clinical benefits in first-line gastric cancer and first-line cervical cancer across all patient populations (regardless of PD-L1 expression), representing breakthrough therapeutic value. Cadonilimab for the treatment of recurrent or metastatic cervical cancer was already included in the NRDL in 2024.

Penpulimab: All 4 Approved Indications Now Covered by NRDL

Penpulimab, a differentiated PD-1 monoclonal antibody, participated in the national reimbursement negotiation for the first time in 2025. Two of its indications—first-line and ≥2L treatment of nasopharyngeal carcinoma (NPC)—have already been approved by the U.S. FDA. During this negotiation, penpulimab successfully secured NRDL inclusion for all four of its approved indications: first-line treatment of squamous NSCLC, first-line treatment of NPC, ≥3L treatment of NPC, and ≥3L treatment of relapsed/refractory classical Hodgkin lymphoma (R/R cHL).

Ebdarokimab (IL-12/IL-23): Psoriasis Indication Now Covered by NRDL

Ebdarokimab is China’s first independently developed innovative drug targeting IL-12/IL-23, and the first approved drug from Akeso in the field of autoimmune diseases. Ebdarokimab participated in the national reimbursement negotiation for the first time in 2025, and its indication for the treatment of moderate-to-severe psoriasis was successfully negotiated and included in the NRDL.

Ebronucimab (PCSK9): Both Approved Indications for Hypercholesterolemia Now Covered by NRDL

Ebronucimab participated in the national reimbursement negotiation for the first time in 2025. The two approved indications of ebronucimab, the treatment of primary hypercholesterolemia and mixed dyslipidemia, and heterozygous familial hypercholesterolemia, were both successfully negotiated and included in the NRDL.

Forward-Looking Statement of Akeso, Inc.

This announcement by Akeso, Inc. (9926.HK, “Akeso”) contains “forward-looking statements”. These statements reflect the current beliefs and expectations of Akeso’s management and are subject to significant risks and uncertainties. These statements are not intended to form the basis of any investment decision or any decision to purchase securities of Akeso. There can be no assurance that the drug candidate(s) indicated in this announcement or Akeso’s other pipeline candidates will obtain the required regulatory approvals or achieve commercial success. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in P.R.China, the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Akeso’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Akeso’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

Akeso does not undertake any obligation to publicly revise these forward-looking statements to reflect events or circumstances after the date hereof, except as required by law.

About Akeso

Akeso (HKEX: 9926.HK) is a leading biopharmaceutical company committed to the research, development, manufacturing and commercialization of the world’s first or best-in-class innovative biological medicines. Founded in 2012, the company has created a unique integrated R&D innovation system with the comprehensive end-to-end drug development platform (ACE Platform) and bi-specific antibody drug development technology (Tetrabody) as the core, a GMP-compliant manufacturing system and a commercialization system with an advanced operation mode, and has gradually developed into a globally competitive biopharmaceutical company focused on innovative solutions. With fully integrated multi-functional platform, Akeso is internally working on a robust pipeline of over 50 innovative assets in the fields of cancer, autoimmune disease, inflammation, metabolic disease and other major diseases. Among them, 26 candidates have entered clinical trials (including 15 bispecific/multispecific antibodies and bispecific ADCs. Additionally, 7 new drugs are commercially available. Through efficient and breakthrough R&D innovation, Akeso always integrates superior global resources, develops the first-in-class and best-in-class new drugs, provides affordable therapeutic antibodies for patients worldwide, and continuously creates more commercial and social values to become a global leading biopharmaceutical enterprise.

TAIPEI, Dec. 7, 2025 /PRNewswire/ — Skymizer today announced that its next-generation HyperThought™ LLM Accelerator IP has been awarded “Best IP/Processor of the Yearˮ and named the “Most Promising Productˮ at the prestigious EE Awards Asia 2025, hosted by ASPENCORE at the Grand Mayfull Taipei Hotel. The dual recognition marks HyperThought as one of the most forward-looking semiconductor IP breakthroughs in the Asia-Pacific technology landscape.

Now celebrating its 5th anniversary, the EE Awards Asia program honors innovations selected by engineers and industry leaders across the region. HyperThought™ stood out among hundreds of entries spanning processors, SoCs, sensors, wireless ICs, AI solutions, and test equipment—earning top distinction as the yearʼs most transformative semiconductor IP.

HyperThought™: Accelerating the Future of Agentic, Multimodal SoCs

Skymizerʼs HyperThought™ represents a new class of multimodal, scalable LLM accelerator IP purpose-built for the coming generation of agentic AI workflows, on-device intelligence, and edge-to-cloud hybrid applications.

Unlike conventional NPUs or fixed-function ML accelerators, HyperThought is architected from the ground up for:

• Multimodal LLM/VLM Execution
  Supporting text, vision, speech, and sensor-based AI with unified token processing.
• Agentic Workflow Optimization
  Accelerating the emerging class of AI agents that require real-time planning, reflection, tool-use, and memory.
• Scalable Edge-to-Enterprise Deployment
  From micro-edge devices and automotive ECUs to humanoid robots, smart cameras,   and industrial IoT gateways.
• Superior Performance-per-Watt and SRAM Efficiency
  Delivering next-generation TTFT, TPS, context window, and latency performance under           strict edge-power envelopes.

Skymizer CMO William Wei: “HyperThought is Built for the Agentic SoC Eraˮ

William Wei, Chief Marketing Officer of Skymizer, represented the company at the EE Awards Asia 2025 ceremony and emphasized the strategic significance of this win:

“HyperThought™ is not just an accelerator IP — it is a foundation for the next decade of agentic intelligence.

From multimodal LLMs to real-time robotic and automotive agents, the future SoC must run AI that plans, reasons, sees, acts, and interacts. HyperThought was designed precisely for this new era.ˮ

Wei added that the award validates Skymizerʼs long-term bet on on-device agentic AI, predicting that LLM-centric SoCs will become the defining architecture for mobile, automotive, robotics, and edge computing.

A Milestone for Skymizer and the Asia Semiconductor Ecosystem

The EE Awards Asia jury highlighted HyperThought for its:

• Breakthrough support for multimodal transformer workloads
• High scalability across process nodes and SoC configurations
• Strong alignment with global trends in on-device LLM inference
• Potential to reshape AI compute in edge, robotics, and smart-device markets

HyperThoughtʼs recognition as “Most Promising Productˮ places Skymizer among the leaders defining next-generation AI silicon, with strong interest from ecosystem partners in automotive, robotics, edge AI, and consumer electronics.

About Skymizer

Skymizer is a Taiwan-based AI semiconductor IP company specializing in LLM acceleration, compiler technology, and agentic AI system architectures. Its flagship HyperThought™ IP gives SoC manufacturers the ability to build their own AI-native processors for multimodal LLMs, autonomous agents, and edge intelligence.

SAN FRANCISCO and SUZHOU, China, Dec. 7, 2025 /PRNewswire/ — Innovent Biologics, Inc. (“Innovent”) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, announces that seven of its innovative products have been included in the updated 2025 National Reimbursement Drug List (NRDL). This list features a new indication of TYVYT® (sintilimab injection), and first-time inclusions of SYCUME® (teprotumumab N01 injection, a recombinant anti-IGF-1R antibody), Limertinib (EGFR TKI), Dupert® (fulzerasib, KRAS G12C inhibitor), DOVBLERON® (taletrectinib, ROS1 inhibitor), Retsevmo® (selpercatinib, RET inhibitor), and Jaypirca® (pirtobrutinib, BTK inhibitor). The updated NRDL will be officially effective from January 1, 2026.

Dr. Michael Yu, Founder, Chairman of the Board and CEO of Innovent, stated: “We are pleased with the NRDL inclusion of our seven innovative therapies this year. These therapies cover key disease areas that pose substantial public health challenges in China—particularly oncology (including lung, liver, gastric, esophageal, gynecological cancers, and hematological malignancies) as well as cardiovascular and metabolic (CVM) diseases. Their inclusion will help broaden patients’ access to and enhance their affordability of these medications, ultimately benefiting more individuals and families across the country. As a company with the mission of ’empowering patients worldwide with affordable, high-quality biopharmaceuticals’, Innovent continues to invest in pioneering treatments across oncology, CVM, autoimmune and ophthalmology—areas of significant societal need. We remain committed to our patient-centered approach, leveraging our innovation and product capabilities to further improve drug affordability and accessibility, so that high-quality medicines can reach and benefit more patients and their families as soon as possible. We are proud to contribute to better care for our patients.”

TYVYT® (sintilimab injection)

TYVYT^® (sintilimab injection) is a PD-1 immunoglobulin G4 monoclonal antibody co-developed by Innovent and Eli Lilly and Company. In China, sintilimab has been approved for eight indications and two more NDAs are under review by the NMPA, including squamous non-small cell lung cancer (NSCLC), non-squamous NSCLC, liver cancer, gastric cancer, esophageal cancer, endometrial cancer and Hodgkin’s lymphoma^[i].

In the updated NRDL, the eighth indication of TYVYT^®(sintilimab injection) is newly included, in combination with fruquintinib for the treatment of patients with advanced endometrial cancer with Mismatch Repair proficient (pMMR) tumors that have failed prior systemic therapy and are not candidates for curative surgery or radiation. This new indication addresses a critical gap in treatments available for advanced endometrial cancer patients with limited responses to traditional therapies.

SYCUME® (teprotumumab N01 injection)

SYCUME^® (teprotumumab N01 injection) is a recombinant anti-insulin-like growth factor 1 receptor (IGF-1R) antibody developed by Innovent. SYCUME^® blocks the activation of IGF-1R signaling pathway, consequently improving clinical manifestations such as proptosis, inflammation and diplopia, thus enhancing quality of life in patients with thyroid eye disease (TED)^[ii].

In the updated NRDL, SYCUME^®(teprotumumab N01 injection) is newly listed for moderate-to-severe thyroid eye disease. SYCUME^®(teprotumumab N01 injection) is China’s first approved IGF-1R antibody drug, and this groundbreaking non-invasive therapy redefines the standard of care and serves the unmet needs for thyroid eye disease over past 70 years in China. The NRDL inclusion will bring this world-class novel treatment option to Chinese patients with thyroid eye disease and significantly enhance patient accessibility and affordability.

Limertinib

Limertinib is a third-generation EGFR TKI in collaboration with ASK Pharm, and Innovent holds exclusive commercialization rights in Mainland China.^[iii]

In the updated NRDL, limertinib is newly listed for: 1) the treatment of adult patients with locally advanced or metastatic EGFR T790M-mutated non-small cell lung cancer (NSCLC), who have previously experienced disease progression during or after treatment with EGFR TKI; and 2) the first-line treatment of adult patients with locally advanced or metastatic NSCLC carrying EGFR exon 19 deletions or exon 21 L858R mutations. Limertinib incorporates a unique naphthylamine group structure, which endows it with enhanced lipophilicity. This property ensures effective drug penetrate across the blood-brain barrier (BBB), thereby significantly reducing the risk of disease progression—specifically, the risk of disease progression in patients with brain metastases and the risk of intracranial disease progression. The NRDL inclusion of limertinib will provide a more effective treatment option for NSCLC patients with EGFR mutations.

Dupert® (fulzerasib)

Dupert^® (fulzerasib) is a novel KRAS G12C inhibitor in collaboration with GenFleet Therapeutics, and Innovent holds exclusive development and commercialization rights in Greater China.^[iv]

In the updated NRDL, Dupert^®(fulzerasib) is newly listed for the treatment of advanced NSCLC adult patients harboring KRAS G12C mutation who have received at least one systemic therapy. The NRDL inclusion of Dupert^®(fulzerasib) will provide a novel targeted therapy benefiting NSCLC patients harboring KRAS G12C mutation.

DOVBLERON® (taletrectinib)

DOVBLERON^® (taletrectinib) is a novel next-generation ROS1 TKI in collaboration with Nuvation Bio China, a Nuvation Bio (NYSE: NUVB) Company, and Innovent holds exclusive commercialization rights in Greater China.^[v]

In the updated NRDL, DOVBLERON^® (taletrectinib) is newly listed for the treatment of adult patients with locally advanced or metastatic ROS1-positive NSCLC. The NRDL inclusion of DOVBLERON^® (taletrectinib) will provide a potentially best-in-class therapy benefiting patients with locally advanced ROS1-positive NSCLC.

Retsevmo® (selpercatinib)

Retsevmo^® (selpercatinib) is a selective and potent rearranged during transfection (RET) kinase inhibitor developed by Eli Lilly and Company and solely commercialized in Mainland China by Innovent.^[vi]

In the updated NRDL, Retsevmo^® (selpercatinib) is newly listed for the treatment of: 1) adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with a RET gene fusion, 2) adult and pediatric patients 12 years of age and older with advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation who require systemic therapy, and 3) adult and pediatric patients 12 years of age and older with advanced or metastatic thyroid cancer with a RET gene fusion who require systemic therapy and who are radioactive iodine-refractory. Retsevmo^® (selpercatinib) is the first RET inhibitor approved globally and its NRDL inclusion will bring an innovative therapy for NSCLC and thyroid cancer patients with a RET alteration.

Jaypirca® (pirtobrutinib)

Jaypirca® (pirtobrutinib) is a non-covalent (reversible) BTK inhibitor developed by Eli Lilly and Company and solely commercialized in Mainland China by Innovent. Jaypirca® (pirtobrutinib) is the first and only non-covalent (reversible) BTK inhibitor approved in the world.^[vii]

In the updated NRDL, Jaypirca^® is newly listed for the treatment of adult patients with relapsed or refractory mantle cell lymphoma after at least two types of systemic therapy, including a BTK inhibitor. Its NRDL inclusion will benefit heavily-treated MCL patients that previously received the treatment of a BTK inhibitor, addressing their unmet needs and further enhancing Jaypirca’s affordability for those patients.

About Innovent

Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that target some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has launched 17 products in the market. It has 1 new drug applications under regulatory review, 4 assets in Phase 3 or pivotal clinical trials and 15 more molecules in early clinical stage. Innovent partners with over 30 global healthcare companies, including Eli Lilly, Roche, Takeda, Sanofi, Incyte, LG Chem and MD Anderson Cancer Center.

Guided by the motto, “Start with Integrity, Succeed through Action” Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.

Statements:

1. Innovent does not recommend the use of any unapproved drug (s)/indication (s).
2. Ramucirumab（Cyramza）, Selpercatinib (Retsevmo) and Pirtobrutinib (Jaypirca) were developed by Eli Lilly and Company.

Forward-Looking Statements

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words “anticipate”, “believe”, “estimate”, “expect”, “intend” and similar expressions, as they relate to Innovent, are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company’s control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company’s competitive environment and political, economic, legal and social conditions.

The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialise or turn out to be incorrect.

SEOUL, South Korea, Dec. 7, 2025 /PRNewswire/ — DWMaterials is accelerating its expansion into the secondary battery and advanced materials industries, leveraging its next-generation electromagnetic separator technology as a foundation for growth.

With over 30 years of accumulated expertise in heat exchanger and reactor engineering, the company is evolving beyond traditional equipment manufacturing to strengthen its position as a technology partner that enhances customers’ quality competitiveness.

In the secondary battery sector, foreign substance removal technology is a crucial factor directly linked to cell quality and safety. Equipped with its proprietary high-purity demagnetization and separation technology, DWMaterials is emerging as a key equipment supplier for next-generation battery production lines.

A company representative stated, “We are not merely an equipment supplier, but a trusted partner that guarantees our customers’ reliability and quality,” adding, “DWMaterials will continue to expand its footprint across the global materials industry.”