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Russell Reynolds Associates Names Dr. Tomas Chamorro-Premuzic as Firm’s First Chief Science Officer

Strategic hire deepens firm’s global leadership advisory capabilities in advanced data, science, and innovation

NEW YORK, Nov. 10, 2025 /PRNewswire/ — Russell Reynolds Associates (RRA), the leading global leadership advisory firm, is pleased to welcome Dr. Tomas Chamorro-Premuzic as its first Chief Science Officer. In this new global role, Dr. Chamorro-Premuzic will lead RRA’s research and development (R&D) and innovation initiatives, driving the firm’s data strategy and the development of proprietary insights to further enhance RRA’s advisory capabilities.

As advanced technology platforms and artificial intelligence continue to transform leadership advisory services, this appointment reinforces RRA’s commitment to leveraging advanced analytics to deepen client impact worldwide. Dr. Chamorro-Premuzic’s role represents a critical new capability, focusing on the content and process aspects of the firm’s data strategy, enhancing the technological advancements led by Chief Technology and Data Officer Harpreet Khurana. In this capacity, Dr. Chamorro-Premuzic will oversee the Center for Leadership Insight, which explores the forces shaping modern leadership, including economic and geopolitical uncertainty, generative AI, board culture, and the development of next-generation leaders. 

“The integration of cutting-edge science and data-driven insights is paramount to delivering unparalleled value to our clients,” said Constantine Alexandrakis, CEO of Russell Reynolds Associates. “Dr. Chamorro-Premuzic is an internationally recognized leader whose profound expertise will be instrumental in shaping our future impact. His appointment as our first Chief Science Officer marks a critical and bold step in advancing the firm’s capabilities and ensuring we remain at the forefront of leadership advisory.”

Dr. Chamorro-Premuzic joins RRA with a distinguished professional and academic background, recognized as a leading, global authority in people analytics, talent management, and leadership development. He previously served as Chief Innovation Officer at ManpowerGroup, in addition to Chief Executive Officer of Hogan Assessment Systems, where he co-created RRA’s proprietary Leadership Span model. Dr. Chamorro-Premuzic is also a co-founder of DeeperSignals, an end-to-end soft-skills intelligence platform, and MyTrudy, a psychometric assessment platform for job seekers. Beyond his corporate leadership, Dr. Chamorro-Premuzic is a Professor of Business Psychology at University College London and Columbia University and is a prolific author of 15 books and over 250 scientific papers.

About Russell Reynolds Associates
Russell Reynolds Associates is a global leadership advisory firm that helps organizations build adaptive leadership capabilities and unlock their potential for growth. We use our global network and deep insights to provide executive search, leadership assessment, and development advisory services across all industries and geographies.

Media Contact
Russell Reynolds Associates
Amy Scissons
Chief Marketing and Communications Officer
amy.scissons@russellreynolds.com

 

TP Honored with Frost & Sullivan’s 2025 Global Competitive Strategy Leadership Recognition for Leveraging AI to Transform Sales Solutions

Recognition reflects its success in redefining global CX outsourcing through innovation, strategy, and performance excellence.

SAN ANTONIO, Nov. 10, 2025 /PRNewswire/ — Frost & Sullivan has recognized global digital business services leader TP with the 2025 Global Competitive Strategy Leadership Recognition in the Business Process Outsourcing (BPO) Customer Experience (CX) Outsourcing Industry for its AI-enabled Revenue-as-a-Service sales solution.

Frost & Sullivan’s independent analysis highlights TP’s ability to reimagine traditional sales and customer engagement models in a rapidly evolving digital landscape. As organizations worldwide adapt to changing customer expectations and increasing technological complexity, TP stands out for its commitment to driving performance through innovation, emotional intelligence, and a globally unified vision.

“TP Revenue-as-a-Service continues to set the benchmark for innovation and excellence within the global BPO CX Outsourcing market,” said Michael DeSalles, Principal Analyst, CX at Frost & Sullivan. “Its AI-enabled platforms, data-driven hiring models, and immersive training programs demonstrate a clear understanding of client challenges and a forward-thinking approach to delivering measurable business outcomes.”

With over 47 years of experience in business sales and operations across more than 300 languages, TP has built an expansive global network of Revenue-as-a-Service sales hubs in Portugal, Spain, Colombia, Brazil, Canada, and Malaysia. The company’s strategy is centered on blending high-tech and high-touch approaches to enhance both B2B and B2C customer experiences.

The company’s proprietary platforms leverage artificial intelligence to optimize lead generation, streamline sales execution, and deliver actionable insights in real time. These innovations empower sales representatives to engage with precision, boosting conversion rates and accelerating the sales cycle for clients worldwide.

TP’s OnTarget recruiting methodology uses a statistical model to identify and hire top-performing sales professionals, while the TP Digital Marketing Academy equips account managers with the latest skills in digital marketing, client reporting, and consultative selling. Over 9,000 graduates have reached the Consultant level through this program, underscoring the company’s commitment to continuous learning and performance excellence.

“At TP, we help businesses grow with expert sales teams, smart automation, and deep industry know-how to create sales experiences that are effective, human, and built for modern B2B growth,” said Daniel Trueman, RaaS President at TP. “We are honored to be recognized by Frost & Sullivan for our efforts to redefine global sales enablement and help clients achieve sustainable growth.”

Frost & Sullivan’s Customer Value Leadership Award is presented each year to companies that show excellence in creating customer value, often by improving the return on investment their customers receive from a product or service. The award recognizes companies that implement strategies focusing on customer experience, technological innovation, and strategic product development.

About Frost & Sullivan

For six decades, Frost & Sullivan has been world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, Mega Trends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion.

Contact:

Lindsey Whitaker
E: Lindsey.Whitaker@Frost.com

Partner Robotics raises Series A funding to deploy robots on construction sites worldwide

BEIJING, Nov. 10, 2025 /PRNewswire/ — Partner Robotics has raised an eight-figure RMB sum in a Series A funding round led by China Growth Capital, with participation from existing investors Cowin Capital and Redpoint China Ventures. Index Capital served as the financial advisor. Including its angel round completed at the end of 2024, the company has raised about RMB 100 million (USD 14 million) to date.

Founded in 2023 by Kecheng Wang, former CEO of Bright Dream Robotics, Partner Robotics is built by a team with years of experience in construction robotics and international expansion. The new capital will support three priorities: developing and commercializing embodied intelligence technologies for construction scenarios, expanding overseas through distribution networks, service centers, and marketing campaigns, and strengthening its supply chain for quality, efficiency and cost optimization strategy.

For now, Partner Robotics is focusing on two products: Floor Tile Paving Robot P900 and  Intelligent Scribing Robot L3000. Both address specific challenges and fit into what the company describes as a “high-value and feasible” product roadmap, with the long-term aim of covering the entire construction lifecycle with embodied intelligence solutions. Partner’s Floor Tile Paving Robot P900 are designed to stabilize quality through precision parameter controls and reduce hollow spots. The company says its system works five to six times faster than human labor. Intelligent Scribing Robot L3000 supports multiple phases of construction, from structure to finishing. It can reportedly deliver four to six times the efficiency of manual work, with accuracy down to a deviation of two millimeters.

On the technical side, Partner Robotics has developed a multi-sensor perception system and a cloud-based simulation platform to continuously train robots with real-world construction data. Its systems also integrate a unified vision-and-motion control model, heavy-load robotic arms, and high-precision optical sensors.

Since mid-2025, Partner Robotics has expanded internationally, securing over RMB10 million (USD 1.4 million) in overseas orders and completing nearly 100,000 square meters of tiling work.

One of its flagship projects took place in Singapore, where the government commissioned a 100-meter by 80- meter pattern for the country’s 60th National Day celebration. Partner Robotics’s scribing robot was selected over competitors including HP and Hitachi, standing out for its precision, efficiency, and adaptability under challenging conditions.

To date, the company’s primary markets span Europe, North America, and the Middle East, with additional sales in mainland China, Hong Kong, Taiwan and Singapore.

Email:info@partnerrobotics.com 

CLEARCHANG Unveils “Rebreeze” at CES 2025 — Redefining Indoor Air Standards with a Smart Window-Mounted Air Purifier

Powered by nano-fiber filtration and AI control technology, Rebreeze delivers cleaner and fresher air through intelligent ventilation.

SEOUL, South Korea, Nov. 10, 2025 /PRNewswire/ — As global interest in air quality and sustainable living continues to rise, CLEARCHANG Co., Ltd. unveiled its innovative window-mounted air purifier, Rebreeze, at CES 2025 in Las Vegas.

CES 2025 : CLEARCHANG
CES 2025 : CLEARCHANG

With decades of experience in natural ventilation and indoor air purification technologies, CLEARCHANG introduces a new form of air purifier that seamlessly integrates design, efficiency, and intelligent control into one system.

A Next Era of Air Purification — Smart, Space-Efficient, and Sustainable Design

The Rebreeze air purifier represents a paradigm shift in how clean air can be delivered into homes and offices. Rather than occupying floor space like traditional air purifiers, Rebreeze is a window-mounted air purifier that integrates directly into the window frame, optimizing both efficiency and aesthetics.

Through its dual air circulation system, Rebreeze simultaneously draws in and purifies outdoor air while expelling indoor pollutants such as CO₂, VOCs, and fine dust—ensuring a consistently fresh and clean indoor environment In Auto Mode, the system intelligently maintains optimal air quality around the clock while minimizing energy consumption, providing a comfortable and sustainable indoor atmosphere without manual operation.

Additionally, the smart ventilation design automatically adjusts airflow based on real-time indoor and outdoor conditions, ensuring continuous balance and comfort. Its quiet operation and energy-efficient performance make it ideal for both residential and office settings. By combining intelligent control with advanced filtration, Rebreeze delivers a seamless air management experience that redefines how modern spaces breathe.

The demand for innovative air purifier systems has surged as urban populations face escalating fine dust levels and climate-induced pollution. CLEARCHANG’s window-mounted air purifier offers a sustainable and elegant response to this challenge. By attaching directly to existing windows, the Rebreeze air purifier eliminates the need for bulky equipment or intrusive installations. The design preserves valuable indoor space while ensuring unobstructed ventilation.

Moreover, this air purifier integrates seamlessly with smart ventilation systems, creating a holistic solution for indoor air purification. Its user-centric design underscores CLEARCHANG’s commitment to combining beauty, function, and sustainability in the modern home environment.
Redefining Air with New AI-Powered Management Experience

At CES 2025, where innovation meets real-world application, CLEARCHANG drew international attention for integrating IoT (Internet of Things) and AI-driven monitoring into the Rebreeze air purifier. This next-generation air purifier enables users to control, analyze, and automate their ventilation and purification routines from anywhere via a mobile app. Through built-in sensors, the air purifier continuously tracks outdoor and indoor air quality metrics—such as PM2.5 concentration, CO₂ levels, and humidity—and adjusts the ventilation system accordingly.

AI algorithms within the air purifier analyze air patterns to predict pollution trends, ensuring preemptive action for maintaining optimal indoor air purification conditions. This smart connectivity allows users to remotely activate their window-mounted air purifier, view live data, and receive alerts about filter maintenance, temperature shifts, or poor air quality. Overall, the Rebreeze air purifier represents a fully autonomous system that minimizes user intervention while maximizing performance and energy efficiency.

The Technology Behind Rebreeze: Smart Innovation for Cleaner Air

Rebreeze features advanced nano-fiber filtration combined with antibacterial materials to capture even ultrafine particles while preventing bacterial growth, extending the filter’s lifespan. This refined filtration system represents CLEARCHANG’s dedication to developing reliable and high-performance air purification technology.

Its quiet and energy-efficient ventilation system keeps air fresh and comfortable throughout the day, maintaining a healthy indoor environment with minimal power use. Designed to adapt seamlessly to everyday spaces, it ensures both comfort and sustainability without compromising performance.

Rebreeze embodies CLEARCHANG’s commitment to practical innovation—delivering cleaner, healthier air through technology that balances efficiency, simplicity, and sustainability for modern living.

Sustainable Innovation for Healthier Living

At the heart of CLEARCHANG’s mission is a belief that air purifier technology should contribute to both human wellness and environmental preservation. The Rebreeze window-mounted air purifier embodies this philosophy with its eco-friendly materials, energy-efficient components, and minimalistic installation.

Unlike portable air purifiers that rely solely on recirculation, Rebreeze enables genuine ventilation, reducing indoor carbon dioxide accumulation while enhancing cognitive health and sleep quality. By maintaining consistent indoor air purification, the system supports families, schools, and workplaces in achieving long-term respiratory well-being.

Looking Ahead: CLEARCHANG’s Vision for the Global Air Purification Market

After a successful debut in the U.S., CLEARCHANG is expanding its reach across Asia, North America, and Europe, aiming to strengthen its position as a global leader in smart air purification and ventilation technology.

Upcoming next-generation models of Rebreeze will feature advanced AI analytics, climate-adaptive control systems, and seamless integration with smart home platforms—offering a more intelligent and personalized air management experience for users worldwide.

Through close collaboration with global partners and research institutes, CLEARCHANG is leading the development of safer, smarter, and more sustainable air management technologies. The company remains committed to creating a healthier and cleaner environment for future generations.

In line with its ESG management philosophy, CLEARCHANG is committed to building a carbon-neutral system that powers its products with solar energy and stores surplus electricity through energy storage systems (ESS). By adopting this sustainable energy model, the company actively contributes to responsible resource use and environmental preservation—advancing its vision of a cleaner, greener future.

TIME’s Best Invention Winner iGarden Swim Jet P Series Officially Launches, Setting a New Standard in Home Pool Entertainment

LOS ANGELES, Nov. 10, 2025 /PRNewswire/ — Fresh from being named one of TIME’s Best Inventions of 2025, iGarden is proud to announce the official launch of its AI-powered iGarden Swim Jet P Series, marking a significant leap in smart pool technology. Engineered with proprietary AI-driven systems, the product redefines home aquatic experiences through intelligent flow control and energy optimization. This launch solidifies iGarden’s position as the leader in the global AI garden revolution, bringing dynamic, sustainable innovation to outdoor living worldwide.


Inspired by jet-engine aerodynamics, the Ramjet-Profile nozzle and smart fluid dynamics create a powerful, fan-shaped current that delivers a wider wave area and natural resistance across the entire body. Powered by InverTurbo Tech, the Swim Jet P Series delivers class-leading water flow up to 1,100 GPM and peak speeds of 4m/s, while the next-generation PMSM motor (up to 1,200 W / 1.6 HP) ensures exceptional energy efficiency and ultra-smooth propulsion. Together with iGarden’s Patented Flow Channel, it produces balanced, even waves that feel as close to open-water swimming as possible—right at home.

The Inverter Drive seamlessly adjusts current strength to match your rhythm, with 5 finely tuned wave modes for everything from calm recovery to playful family moments. Whether it’s an early-morning fitness routine, low-impact rehabilitation, or weekend games with friends, iGarden Swim Jet P Series turns any pool into a multifunctional aquatic hub. Its wider coverage allows multiple users to swim, train, or play together comfortably, bringing energy and connection into every moment spent outdoors.


Built from marine-grade stainless steel, iGarden Swim Jet P Series combines enduring strength with minimalist beauty. Its robust stainless-steel brushless motor is engineered for long-term reliability, and iGarden backs the system with a 3-Year-Warranty, offering premium confidence and worry-free ownership for every household.

In August 2025, iGarden formalized a partnership with USA Artistic Swimming (USAAS). National-level athletes and coaches have incorporated iGarden Swim Jet P Series into their training, validating its professional performance and versatility. “We just upgraded our backyard experience with the Swim Jet. We love it,” said Adam Andrasko, CEO of USA Artistic Swimming.

Getting started is simple. Installation is fast, flexible, and worry-free: iGarden Swim Jet P Series supports both deck and wall mounting and adapts easily to new builds or existing pools, while iGarden’s turnkey deck-drilling solution streamlines setup so you can be swimming “before your first coffee cools.” iGarden Swim Jet P Series is now officially available for purchase; pre-order by Dec 31, 2025 to receive free professional installation (a $600+ value; US only), plus up to $1,000 in introductory savings for early buyers at igarden website.


About iGarden

As the innovative sub–brand of Fairland Group, iGarden is leading the global AI Garden revolution. By fusing advanced AI with eco–smart design, we create outdoor spaces that think, adapt, and self–manage. Our curated portfolio—from AI–enhanced pool cleaners and swim jets to smart lawn mowers, AI–driven pumps, and AIoT systems—delivers a seamless lifestyle that is quiet, sustainable, and beautifully intelligent.

With iGarden, outdoor living becomes a feeling—of ease, of connection, of art in everyday motion.

Always Intelligent. Always Inspiring. Always Sustainable

Media contact
Mengru Li
Media Relations, Fairland Group / iGarden
mengruli@fairlandgroup.com 

NYSE Content Advisory: Pre-Market Update + ICE Data Shows October Home Prices Up 0.9%

NEW YORK, Nov. 10, 2025 /PRNewswire/ — The New York Stock Exchange (NYSE) provides a daily pre-market update directly from the NYSE Trading Floor. Access today’s NYSE Pre-market update for market insights before trading begins. 

 

Kristen Scholer delivers the pre-market update on November 10th

  • Global equities are rallying Monday morning on hopes that the U.S government shutdown is nearing an end. On Sunday, the U.S. Senate advanced a bill that would reopen government after its longest shut down in history.
  • Intercontinental Exchange’s monthly mortgage monitor was released, showing home prices rose 0.9% annually in October, bucking nine straight months of contraction. Purchase demand held steady despite headwinds.
  • The 60th annual EEI Financial Conference kicked off in Florida yesterday, designed to connect leadership from investor-owned electric companies and the financial community.

Opening Bell
Eni (NYSE: E) celebrates 30th anniversary of listing

Closing Bell
Blackstone (NYSE: BX) celebrates its 40th anniversary of founding

Click here to download the NYSE TV App

 

Abu Dhabi Investment Office announces 29 strategic partnerships to accelerate commercialisation of autonomous mobility

 ABU DHABI, UAE, Nov. 10, 2025 /PRNewswire/ — Abu Dhabi Investment Office (ADIO) has announced 29 commercial deployment agreements for autonomous mobility technologies on the sidelines of Abu Dhabi Autonomous Summit, held as part of the inaugural Abu Dhabi Autonomous Week (ADAW).

Abu Dhabi Autonomous Week
Abu Dhabi Autonomous Week

Marking a decisive moment in global smart mobility, the landmark deals, secured by ADIO with partnerships involving K2, LODD Autonomous (LODD), Autologix, Sinaha, TractEasy, MLG and Space42, establish the capital as among the first cities globally to introduce an integrated,  multi-modal autonomous regulatory and infrastructure environment that enables companies to transition from the pilot phase to commercial deployment. Attracting inward investment and partnerships, and with testing grounds to take technology to full-scale commercialisation, Abu Dhabi has become a global destination for next-generation companies in the autonomous sector seeking to set up, innovate, test and scale their technologies.

The 29 commercial agreements span critical sectors, from e-commerce, food and goods delivery with partners such as Integrated Transport Centre (AD Mobility), Talabat, Noon, and Aramex, to healthcare delivery and logistics with PureLab, and industrial logistics automation.

Proven autonomous solutions for air and ground delivery, alongside specialised industrial applications, have commenced real-world operations across Abu Dhabi. This integrated approach, regulated and enabled across the entire range of transportation modes  by SASC, is changing  how consumers and companies send and receive goods .

A focus on autonomous innovation and sustainable, safe  and efficient adoption bring s  a customer-centric future logistics network a step closer to being fully operational. SASC has created an enabling environment across infrastructure, regulation and security to allow for the assessment of commercial viability as well as extensive real-world testing of autonomous solutions in Abu Dhabi.

His Excellency Badr Al-Olama, Director General of the Abu Dhabi Investment Office, said: “Abu Dhabi is leading the transformation in smart mobility and logistics, with these 29 commercial pilot agreements marking a decisive step toward a future where autonomous technologies set new standards for transportation and trade. Anchored by the Smart and Autonomous Vehicle Industries (SAVI) cluster, these agreements translate decades of R&D into tangible commercial deployment. Together, they represent a defining moment, where technology begins to function as a viable and vital part of the global economy.

“This shift is enabled by the Smart and Autonomous Systems Council’s vision for a coordinated approach in which regulation, infrastructure and industry development advance together, creating a clear path for deployment, commercialisation and wider adoption. By advancing solutions that support e-commerce, healthcare and critical logistics, we are reinforcing Abu Dhabi’s position as a place where emerging industries can grow faster, scale further and deliver lasting impact to businesses and communities worldwide.”

Sinaha Technology, an Abu Dhabi-based company specialising in AI-driven automation, robotics and drone solutions is developing logistics innovations that are transforming the movement of goods. These include autonomous ground vehicles (AGVs) operating continuously to reduce emissions and costs, to intelligent warehouses powered by robotics and AI, and a digital Fleet Management System delivering real-time visibility and predictive efficiency.

The new approach to logistics management also extends to Abu Dhabi’s aerial logistics network through several pioneering drone delivery pilots led by LODD, working alongside PureLab, EMX, Noon and Aramex. The pilots will demonstrate the commercial, operational and environmental potential of unmanned aerial systems, from the secure, cold-chain transport of medical samples to scalable parcel and mail delivery between sorting hubs and community drop-off zones.

Abu Dhabi is further scaling autonomous logistics through a series of partnerships led by K2, in collaboration with Talabat, EMX, ENEC, Noon and the Department of Municipalities and Transport. These pilots, which span both air and land applications, will demonstrate how AI-enabled electric vehicles and aerial drones can transform last- and middle-mile delivery. From autonomous drones flying parcels between Talabat hubs and drop-off stations, to ground vehicles servicing logistics routes across Abu Dhabi, the projects combine innovation, sustainability, and operational efficiency. The introduction of fully electric Robosweepers and autonomous ground fleets for major logistics partners further underscores Abu Dhabi’s leadership in deploying real-world, city-wide autonomy that enhances productivity, supports net-zero targets, and strengthens the emirate’s position as a global hub for smart mobility and intelligent logistics.

Ground delivery pilots have also been extended to heavy goodswith the launch of a partnership between Autologix (a joint venture of 7X and Zelostech) and Emirates Post. The pilot will deploy Level 4 autonomous cargo vehicles in Abu Dhabi. Designed without a driver’s cab or steering wheel, the purpose-built vehicles represent a new generation of urban logistics that is safer, more efficient, and fully electric.

Collectively, these initiatives reflect Abu Dhabi’s integrated approach to mobility, aligning infrastructure, regulation and innovation under SASC to advance sustainable, next-generation freight and logistics. Together, they demonstrate how autonomy and innovation are redefining efficiency, safety and environmental performance, while positioning Abu Dhabi as a global leader in smart mobility and regulatory excellence, charting the course for autonomous economies of the future.

About the Smart and Autonomous Systems Council (SASC)

Established in 2024, the Smart and Autonomous Systems Council (SASC) is responsible for setting the strategic direction of Abu Dhabi’s smart and autonomous technologies sector. Driving policy, regulation, investment and innovation through collaboration with government entities, global innovators and industry stakeholders, SASC is shaping a world-class ecosystem that positions Abu Dhabi at the forefront of future technologies and as a leading global hub for intelligent mobility and autonomous systems.

About Abu Dhabi Autonomous Week

Abu Dhabi Autonomous Week (ADAW) is the emirate’s flagship platform for advancing smart mobility and autonomous systems across land, sea, air, robotics and industry. Organised by the Smart and Autonomous Systems Council (SASC), the inaugural edition brings together global sector leaders, policymakers, innovators and investors to connect, collaborate and accelerate the future of autonomous technology. Commencing with the Abu Dhabi Autonomous Summit, the week’s flagship event for high-level dialogue and partnerships, the programme is further strengthened by initiatives such as DRIFTx, RoboCup Asia-Pacific 2025 (RCAP 2025) and Abu Dhabi Autonomous Racing League (A2RL), reinforcing Abu Dhabi’s role as a global hub for innovation, investment and the safe, sustainable deployment of autonomous technologies.

Brii Biosciences Presents Late-Breaking Data from Ongoing Phase 2 ENSURE Study at AASLD 2025, Reinforcing BRII-179’s Potential as a Curative Treatment for Chronic Hepatitis B

  • Cohort 4 follow-up confirms durable hepatitis B surface antigen (HBsAg) loss at 24 weeks post end of treatment (EOT) in BRII-179 anti-HBs responders treated with elebsiran plus pegylated interferon alfa (PEG-IFNα)
  • Data suggest the potential to shorten PEG-IFNα treatment duration for BRII-179 anti-HBs responders showing faster and greater HBsAg reduction

DURHAM, N.C. and BEIJING, Nov. 10, 2025 /PRNewswire/ — Brii Biosciences Limited (“Brii Bio,” or the “Company”, stock code: 2137.HK), a biotechnology company developing therapies to improve patient health and choice across diseases with high unmet medical needs, announced 24-week post end of treatment (EOT) follow-up results from Cohort 4 of its ongoing Phase 2 ENSURE study. These late-breaking data were presented at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting®, held in Washington D.C. from November 7-11, 2025, and were simultaneously published in Nature Medicine (link).

ENSURE (NCT05970289) is a multicenter, open-label Phase 2 study in the Asia-Pacific region. Cohort 4 evaluates a novel sequential combination treatment strategy for hepatitis B virus (HBV), utilizing Brii Bio’s therapeutic vaccine, BRII-179, to prime and enrich patients, with a goal to improve responsiveness to therapies potentially offering a functional cure. Participants previously treated with nine doses of elebsiran and BRII-179 treatment in a prior Phase 2 study BRII-179-835-001 (NCT04749368) were enrolled to this cohort to receive 48 weeks of combination treatment with elebsiran and PEG-IFNα. These participants were categorized as BRII-179 anti-HBs responders or non-responders based on their peak hepatitis B surface antibody (anti-HBs) levels during the prior study (≥10 IU/L or <10 IU/L, respectively). 

EOT data from Cohort 4 were previously presented at the European Association for the Study of the Liver (EASL) Congress 2025. The newly reported data confirm that the HBsAg loss benefit in the BRII-179 responder group was sustained over time. At EOT, 58% (11/19) HBsAg loss was observed in BRII-179 anti-HBs responders. In anti-HBs non-responders, only 17% (2/12) achieved HBsAg loss. At 24 weeks post EOT, 42% (8/19) of anti-HBs responders maintained HBsAg loss compared to 8% (1/12) of anti-HBs non-responders. 50% (4/8) of anti-HBs responders with sustained HBsAg loss at 24 weeks post EOT had baseline HBsAg levels between 1,514-3,086 IU/mL when enrolled in the previous BRII-179-835-001 study suggesting BRII-179 may elicit anti-HBs responses even in patients with higher baseline surface antigen levels. This supports BRII-179’s potential to improve functional cure outcomes and broaden its applicability across diverse patient populations. 

To further define BRII-179’s role in treatment of HBV infection and optimize combination regimens for pivotal studies, Brii Bio is conducting two additional Phase 2b trials. The ENRICH study evaluates the role of BRII-179 in priming HBV-specific immunity and/or identifying immuno-responsive patients with a higher likelihood of achieving functional cure. The ENHANCE study includes two parts: one to evaluate the triple combination of BRII-179, elebsiran and PEG-IFNα given concurrently for 48 weeks, and another exploring a sequential approach of BRII-179 and elebsiran for 24 weeks followed by triple combination for 24 weeks, and a 48-week PEG-IFNα control arm. Both studies are fully enrolled, and EOT data are expected to be presented in 2026.

“We are encouraged to see that the difference in HBsAg seroclearance rates observed at EOT was maintained through 24 weeks of follow-up.” said David Margolis, MD, Chief Medical Officer of Brii Bio. “These results support BRII-179’s potential to deliver more rapid and durable HBsAg loss and potentially enable a shorter treatment duration of PEG-IFNα. We look forward to validating these findings in our ongoing confirmatory studies.”

Publication Number: 5036

Title: Chronic hepatitis B virus infected participants responding to prior BRII-179 treatment achieved higher rate of sustained hepatitis B virus surface antigen loss on elebsiran plus pegylated interferon alfa: follow-up data from ENSURE study

Presenter: Grace Lai-Hung Wong, MBChB (CUHK), MD (CUHK), FRCP (Lond, Edin), FHKCP, FHKAM (Medicine), Professor of Gastroenterology and Hepatology at CUHK Medical Data Analytics Centre (MDAC) and Department of Medicine and Therapeutics in Hong Kong SAR, China

  • A total of 31 participants were analyzed, with 19 BRII-179-induced anti-HBs responders and 12 non-responders.
  • Median [range] HBsAg at baseline of this ENSURE study was numerically higher in anti-HBs responders (520 [34-2165] IU/mL) than in non-responders (185 [51-672] IU/mL).
  • At 24 weeks post EOT, a notably higher rate of HBsAg loss was achieved in BRII-179-induced anti-HBs responders (8/19, 42.1%) compared to non-responders (1/12, 8.3%).
  • Although all participants with sustained HBsAg loss had HBsAg < 1,500 IU/mL at baseline of this ENSURE study, 4/8 (50.0%) from anti-HBs responders had baseline HBsAg ranging from 1,514-3,086 IU/mL when enrolled in the previous study, suggesting that BRII-179 may induce anti-HBs responses regardless of baseline HBsAg level.
  • The elebsiran and PEG-IFNα combination was generally safe and well-tolerated.

About Hepatitis B

Hepatitis B virus (HBV) infection is one of the world’s most significant infectious disease threats with more than 254 million people infected globally.[1] Chronic HBV infection is the leading cause of liver disease and an estimated 820,000 people die of complications from chronic HBV infection each year.[1] HBV is of exceptional concern in China, where 87 million people are chronically infected.[2]

About BRII-179

BRII-179 is a novel recombinant protein-based HBV immunotherapeutic candidate that expresses the Pre-S1, Pre-S2, and S HBV surface antigens, and is designed to induce enhanced and broad B-cell and T-cell immunity. In November 2023, the Center for Drug Evaluation (the “CDE”) of the National Medical Products Administration (the “NMPA”) granted BRII-179 Breakthrough Therapy Designation.

About Elebsiran

Elebsiran is an investigational subcutaneously administered HBV-targeting siRNA designed to degrade hepatitis B virus RNA transcripts and limit the production of hepatitis B surface antigen. It has the potential to have direct antiviral activity against HBV and HDV. It is the first siRNA in the clinic to include Enhanced Stabilization Chemistry Plus technology to enhance stability and minimize off-target activity, which potentially can result in an increased therapeutic index. Brii Bio licensed exclusive rights to develop and commercialize elebsiran for the Greater China territory from Vir Biotechnology, Inc. in 2020. In May 2024, the CDE of the NMPA granted elebsiran Breakthrough Therapy Designation.

About Brii Bio

Brii Biosciences Limited (“Brii Bio“, stock code: 2137.HK) is a biotechnology company developing therapies to address major public health challenges where patients experience high unmet medical needs, limited choice and significant social stigmas. With a focus on infectious diseases, the Company is advancing a broad pipeline of unique therapeutic candidates with lead programs against hepatitis B virus (HBV) infection. The Company is led by a visionary and experienced leadership team and has operations in key biotech hubs, including Raleigh-Durham, the San Francisco Bay Area, Beijing and Shanghai. For more information, visit www.briibio.com.

[1] World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https://www.who.int/publications/i/item/9789240091672 

2 World Health Organization. Hepatitis. World Health Organization. Retrieved from https://www.who.int/china/health-topics/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C