From bustling cities to the great outdoors

OSAKA, Japan, Oct. 20, 2025 /PRNewswire/ — The Expo 2025 Osaka, Kansai, which wrapped up to resounding acclaim, drew a total of 25,578,986 visitors by October 13, having already surpassed the benchmark of 22 million—key to breaking even on operating costs—on September 27. The Development Bank of Japan has released a survey on inbound tourist trends during the Expo period. Among visitors to the Expo itself, arrivals from East Asia exceeded 35% as of June and accounted for nearly half by September. A large number of tourists also took the opportunity to visit Kyoto and Nara alongside the Expo.

Kintetsu Railway Co., Ltd. (hereinafter referred to as Kintetsu), headquartered in Osaka, operates Japan’s longest private railway network, connecting iconic destinations such as Osaka, Kyoto, Nara, Nagoya, and Mie, and it saw a major influx of tourists along its routes during the Expo. To keep this buzz going, we will ramp up our promotional efforts to highlight unique appeals while delivering even more convenient services and seamless access, such as simply scanning a QR code or tapping a credit card to board. From trains that transform travel time between big cities like Osaka and Nagoya into pure enjoyment, to breathtaking natural landscapes, Japanese traditions and cuisine, and one-of-a-kind local experiences, we will craft journeys for international visitors that truly capture the spirit of each destination.

The charming “Oshawott Liner” Pokmon train begins operation

Japan’s world-famous anime and game series, Pokémon, has captured audiences worldwide with its beloved characters. Among them, “Oshawott” serves as the official support Pokémon for Mie Prefecture. In February 2025, the collaborative “Oshawott Liner” train began operation in partnership with Kintetsu’s “Ise-Shima Liner.” From its exterior to its interior, the train is adorned with Oshawott designs, delighting both adults and children during every ride.

Matsusaka City – Savor Gourmet Delights and Discover Japan’s Traditional Crafts

Savor Matsusaka Beef at Isshobin Miyamachi Branch

At Isshobin Miyamachi Branch, you can enjoy Yakiniku with Matsusaka beef, one of “Japan’s three top Wagyu” varieties. The tender, finely marbled meat is grilled on a rotating grill, allowing you to choose your preferred cuts. Reasonably priced, the restaurant is popular with both locals and tourists.

Access: 12-minute walk from Matsusaka Station

Experience Traditional “Matsusaka Momen“ Weaving

Matsusaka City offers opportunities to experience its traditional textile culture, passed down since the Edo period. Matsusaka cotton, a traditional industry of Matsusaka City, is famous for its indigo-dyed striped fabrics, known as “Matsusaka stripes,” which were once popular fashion among Edo-period commoners. The delicate, hand-woven fabric becomes richer in color and develops greater texture with each wash. At the Matsusaka Momen Handloom Center, you can participate in the “Petit Princess Experience,” sitting at a traditional loom to weave patterned fabrics thread by thread, while immersing yourself in the fashion culture of Edo-period commoners.

Petit Princess Experience
Fee: ¥1,500 (tax included)
Duration: 1 hour (including staff guidance)
Participants: 1 to 4 people
[Available hours] 9:00 AM to 3:00 PM
(Course includes weaving small decorative mats approximately 11×20 cm)
Access: 11-minute walk from Matsusaka Station

Matsusaka Kimono Experience – Yawataya

In addition to creating Matsusaka cotton fabric, visitors can experience traditional kimono dressing. The specially designed Matsusaka cotton kimonos from “Yawataya” can be worn in just five minutes, making them ideal for visitors on a tight schedule. The distinctive blue of Matsusaka cotton beautifully complements the surrounding architecture, and strolling through Residences of Castle Guards and Matsusaka Park in kimono makes for stunning photographs.

Access: 7-minute walk from Matsusaka Station

Ise Area

– A Must for Stunning Natural Scenery

No trip to the Ise area is complete without enjoying its beautiful natural landscapes. The Asama Mountain Summit Observatory on the Ise-Shima Skyline, located along the border of Ise and Toba in Mie Prefecture, offers breathtaking panoramic views of Ise-Shima National Park. From the observatory, visitors can enjoy scenic views of Ise Bay and Toba Bay’s rias coastline. The observatory also features cafes, foot baths, and other rest facilities, along with a popular photo spot called the “Sky Mail Post.“

Access: 15 minutes by car from Toba Station (additional toll fee required for Ise-Shima Skyline)

Shima Area

– A Haven for Gourmet Food and Fun Experiences

Matoya Oyster Terrace

Located in Shima, Matoya Bay is famous for its oyster farming, and the “oyster huts” open every winter. Among these, the “Matoya Oyster Terrace,” operated by Sato Oyster Farm, serves fresh raw oysters and oyster dishes year-round. Enjoying oysters right on the terraces at the water’s edge is a truly exceptional experience, and the unique seaside atmosphere makes dining here extra special.

Access: 15 minutes by car from Shima-Isobe Station or Ugata Station

Shima Green Adventure

Shima Green Adventure is a large outdoor facility in Shima, offering a wide range of adventure attractions. Its highlight is the “Zip Dive,” Japan’s longest prone-position zipline at approximately 620 meters, where riders can soar above the forest and coastline. The attraction delivers both thrills and breathtaking views. The park also features climbing towers, laser battles, forest jumps, and a drone garden. Adjacent to the adventure area is a glamping site, making it an ideal destination that combines excitement with relaxation.

Access: About 10 minutes by free shuttle bus from Ugata Station

Shima Nature School

At “Shima Nature School,” visitors can enjoy a variety of outdoor activities, including sea kayaking. The calm waters of Ago Bay, surrounded by over 60 islands, create a safe and scenic environment perfect for beginners and families. It’s an ideal place to relax and connect with nature.

Access: 20 minutes by car from Ugata Station or Kashikojima Station

Pearl Workshop “Pearl Village”

At “Pearl Village,” surrounded by the tranquil waters of Ago Bay, visitors first watch a video explaining the value and growth process of pearls before selecting shells with expert guidance and experiencing the thrill of extracting pearls themselves. Visitors can also have jewelry made using pearls extracted on-site. Staff promptly craft them into souvenir pendants or earrings, resulting in a truly unique keepsake.

Access: 30 minutes by car from Ugata Station or Kashikojima Station

– A Special Stay Experience

Kashikojima Hojoen

“Kashikojima Hojoen,” located on Kashikojima Island where the 2016 G7 Ise-Shima Summit was held, is a high-end hot spring ryokan in the Ise-Shima area featuring spacious natural hot spring baths and beautiful garden-view open-air baths that overlook the sea. Breathtaking panoramic views make you feel as though you’re floating on the sea itself. The hot springs are fed by 100% natural spring water, renowned for their moisturizing and skin-beautifying properties, offering deep relaxation for both body and mind. The facility includes a souvenir shop, spa, and karaoke. The special “Suikei” floor offers rooms with large windows overlooking the sea and bay, where guests can feel a serene connection with the ocean and enjoy a truly relaxing and memorable stay.

Access: 3 minutes by free shuttle bus from Kashikojima Station

Miyako Resort Shima Bayside Terrace

“Miyako Resort Shima Bayside Terrace” offers an exotic European atmosphere, perfect for romantic couples, families, and longer stays. Here, you can create special vacation memories while watching the sunrise and sunset over Ago Bay. The beautiful Southern European-style architecture, featuring pure white walls and red-tiled roofs, evokes the charm of a picturesque seaside town abroad, and dinner features luxurious French-style cuisine. The natural scenery combined with its design creates not just a resort atmosphere, but some guest rooms also feature private balconies, offering warm spaces with charming ambiance.

Access: 7 minutes by free shuttle bus from Kashikojima Station

Discover hidden gems in Kansai: Experience the beautiful nature, gourmet cuisine, and culture in Ise-Shima through your five senses.

SHENZHEN, China, Oct. 20, 2025 /PRNewswire/ — From October 15 to 19, 2025, SKYWORTH showcased its all-new Matte Screen Ultra TV series, alongside a selection of standout TV products, at the 138th China Import and Export Fair (Canton Fair), highlighting its innovation and brand strength to visitors from around the world. As a long-standing exhibitor, SKYWORTH continues to uphold its core philosophy of “product first, continuous innovation,” committed to delivering better experiences for users globally.

Founded in 1988, SKYWORTH has grown into a global technology leader with operations spanning over 40 countries and regions, consistently ranked among the world’s top five TV brands by shipment volume. SKYWORTH is dedicated to innovation in television display technologies, continuously improving user experiences and driving industry advancement, with extensive expertise in OLED, QLED, and Mini LED technologies. Its strong product performance and brand influence have earned growing recognition in international markets, establishing SKYWORTH as a regular highlight at the Canton Fair.

At the 138th Canton Fair, SKYWORTH unveiled its latest Matte Screen Ultra QD-Mini LED TV series, marking a major leap in next-generation display technology. Featuring multiple layers of high-performance materials, the new screen achieves exceptional contrast, ultra-wide viewing angles, and brilliant brightness, while its anti-glare design enhances visual comfort. The result is OLED-level performance, with deeper blacks, sharper contrast, and crystal-clear, glare-free images even in bright environments. Viewers can enjoy vivid and accurate colors from any position —sitting, lying down, or moving across the room—bringing a truly immersive experience to everyday viewing. Together, these innovations redefine what premium home entertainment looks and feels like.

Beyond cutting-edge technology, SKYWORTH showcased its rich and diverse product portfolio. Highlights included the 100-inch Frame+ TV, one of the largest models in its class, which doubles as a wall-mounted art piece, blending interior aesthetics with entertainment. Also on display were SKYWORTH’s globally best-selling 100-inch TVs, high-performance gaming TVs with superior sound, the world’s first AI Karaoke Google TV, and a range of portable TVs. This dynamic mix of products and smart interactive experiences created an engaging and inspiring showcase for all visitors.

The 138th Canton Fair once again demonstrated SKYWORTH’s unwavering commitment to innovation, quality, and user experience, impressing visitors from around the world. To explore SKYWORTH’s full range of breakthrough products and cutting-edge technologies, visit: https://overseas.skyworth.com/en/home.

UDAIPUR, India, Oct. 20, 2025 /PRNewswire/ — India based Hindustan Zinc Limited, a Vedanta Group company and the world’s largest integrated zinc producer, announced its financial results on 17^th October 2025 for the second quarter and half year ended 30^th September 2025.The company reported its best-ever second quarter mined metal production of 258 Kt, alongside five-year lowest zinc cost of production excluding royalty at $ 994 per tonne. The company also recorded its highest-ever 2Q revenue from operations of US$ 979 million, up 10% QoQ and 4% YoY, and best-ever second-quarter EBITDA of US$ 512 million, up 16% QoQ and 7% YoY, maintaining industry-leading EBITDA margin of 52%. Resultantly, profit after tax stood at US$ 303 million, rising 19% QoQ and 14% YoY.

Hindustan Zinc employees with ingots

Silver remained a strong contributor, driving approximately 40% of overall profitability. During the quarter, Hindustan Zinc also delivered superior total shareholder returns of 7%, underscoring its consistent value creation. Reflecting strong market performance and investor confidence, the company was included in Nifty 100 and Nifty Next 50 indices, effective September 30, 2025. The Board approved India’s first 10 Mtpa Zinc Tailings Reprocessing Plant, a milestone in advancing resource circularity and sustainable growth.

Commenting on Hindustan Zinc’s performance, Arun Misra, Chief Executive Officer, said:

“I am delighted to share that we have delivered the best-ever second quarter mined metal production with a 5-year lowest zinc cost of production of $994 per tonne, reflecting the continuous operational excellence, technology intervention and dedication of our people. Our inclusion into the International Council on Mining and Metals (ICMM) as the first-ever from India reiterates our deep commitment to responsible and sustainable mining. As we embark on our next phase of 2x growth expansion, recovering value from every resource, reusing materials through circular processes and growing portfolio of energy transition metals, we are driving India’s journey towards clean energy independence.”

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About Hindustan Zinc Limited:

Hindustan Zinc Limited, a Vedanta Group company, is the world’s largest integrated zinc producer. The company has been recognized as the world’s most sustainable metals & mining company by the S&P Global CSA 2024 and the first Indian company to become an ICMM member.

Media Contact:
Maitreyee Sankhla (Head Corporate Communications)
maitreyee.sankhla@vedanta.co.in 

Disclaimer

This release contains forward-looking statements that may differ from actual results. We undertake no obligation to update them.

SHANGHAI and HONG KONG, Oct. 20, 2025 /PRNewswire/ — Antengene Corporation Limited (“Antengene”, SEHK: 6996.HK), a leading innovative, commercial-stage global biotech company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for hematologic malignancies and solid tumors, today announced that the latest results from the ongoing Phase I/II CLINCH study of ATG-022 (CLDN18.2 antibody-drug conjugate [ADC]), were presented in a Poster Presentation at the European Society for Medical Oncology Congress 2025 (ESMO 2025) in Berlin, Germany.

Details of the Poster Presentation:
ATG-022 (CLDN18.2 antibody-drug conjugate)
Title: Phase I/II study of Claudin 18.2 ADC ATG-022 in patients with advanced gastric/ gastroesophageal junction cancer (CLINCH)
Abstract Number: 2907
Presentation Number: 2113P

ATG-022 and CLINCH Study Overview

• ATG-022 is a CLDN18.2-targeted ADC with sub-nM affinity and fast internalization. Using a VC-MMAE linker-payload (DAR 4), ATG-022 has demonstrated potent activity across tumors with high, low, and ultra-low CLDN18.2 expression.
• The ongoing Phase I/II CLINCH study consists of dose escalation and dose expansion phases. In dose escalation, patients with advanced solid tumors regardless of CLDN18.2 expression receive ATG-022 once every three weeks (0.3-3.0 mg/kg Q3W) to evaluate the safety, tolerability, and pharmacokinetics; CLDN18.2-positive (≥ IHC 1+, 1%) patients are treated at 1.8 mg/kg or 2.4 mg/kg in dose expansion to evaluate the efficacy and safety.
• ATG-022 has been granted two Orphan Drug designations (ODDs) by the U.S. Food and Drug Administration (FDA) for the treatment of gastric cancer and pancreatic cancer, and in August 2025 obtained Breakthrough Therapy Designation from China’s National Medical Products Administration (NMPA) for treating CLDN18.2-positive, HER-2 negative unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (GC/GEJC) who have received at least two prior lines of therapy.

Key Results from the CLINCH Study

• Efficacy Data
  • Among GC/GEJC patients with moderate/high CLDN18.2 expression (IHC 2+ > 20%), the 2.4 mg/kg dose cohort observed 1 complete response (CR), 11 partial responses (PRs) and 15 stable diseases (SDs), resulting in an objective response rate (ORR) of 40% (12/30) and a disease control rate (DCR) of 90% (27/30). The median progression-free survival (mPFS) was 6.97 months and the 12-month overall survival (OS) rate was 66.2%. In the 1.8 mg/kg dose cohort, there were 1 CR, 9 PRs, and 11 SDs, resulting in an ORR of 40% (10/25) and a DCR of 84% (21/25).
  • Among GC/GEJC patients with low/ultra low CLDN18.2 expression (IHC 2+ ≤ 20%), patients treated at the efficacious dose of 1.8-2.4 mg/kg achieved 1 CR and 5 PRs, resulting in an ORR of 33.3% (6/18) and a DCR of 50% (9/18). The patient with CR has demonstrated durable response and has been on the study for over 22 months.
  • To date, the study has observed three CRs, one from each of the three forementioned cohorts (two dose cohorts among CLDN18.2 mid/high expressors and the cohort of low/ultra low CLDN18.2 expressors). This broad-spectrum antitumor activity indicates ATG-022’s potential as a new treatment option for a broader population of patients).
• Safety Data
  • At 2.4 mg/kg in the dose expansion, 45.8% of patients had ≥1 treatment-emergent adverse events (TEAEs), 60.4% of patients had grade ≥3 TEAEs. The most common grade ≥3 treatment-related adverse events (TRAEs, ≥5% of patients) were neutrophil count decrease (16.7%), decreased appetite (14.6%) and anaemia (8.3%).
  • In the dose-expansion phase, the 1.8 mg/kg cohort demonstrated excellent safety and tolerability, with only 13.6% of patients reporting serious TEAEs and 18.2% reporting Grade ≥3 TEAEs. The favorable safety profile of this dose level support its potential use in first-line combination regimens with chemotherapy and immune checkpoint inhibitors.
  • No ophthalmological toxicities or interstitial lung disease have been observed.

Conclusions and Outlook

• ATG-022 demonstrated a manageable safety profile and encouraging antitumor effects in GC/GEJC adenocarcinoma patients with a broad range of CLDN18.2 expressions, thus supporting further clinical investigation in patients with variable CLDN18.2 expressions. In addition to GC/GEJC, preliminary efficacy has been observed in other non-GI tumor types which will be reported at upcoming conferences.
• The 2.4 mg/kg cohort showed a favorable safety profile, while the 1.8 mg/kg cohort demonstrated even better safety and tolerability. These findings provide strong support for advancing ATG-022 in combination with immune checkpoint inhibitors and chemotherapy in first-line treatment settings, paving the way to significantly expand its clinical reach and commercial potential.
• The Phase II dose expansion study of ATG-022 is going smoothly in China and Australia. In parallel, Antengene is actively preparing for combination therapy studies involving ATG-022 to further advance its clinical development.

About Antengene

Antengene Corporation Limited (“Antengene“, SEHK: 6996.HK) is a global, R&D-driven, commercial-stage biotech company focused on developing first-in-class/best-in-class therapeutics for diseases with significant unmet medical needs. Its pipeline spans from preclinical to commercial stages and includes several in-house discovered programs, including ATG-022 (CLDN18.2 ADC), ATG-037 (oral CD73 inhibitor), ATG-101 (PD-L1 × 4-1BB bispecific antibody), ATG-031 (CD24-targeting macrophage activator), and ATG-042 (oral PRMT5-MTA inhibitor).

Antengene has also developed AnTenGager™, a proprietary T cell engager 2.0 platform featuring “2+1” bivalent binding for low-expressing targets, steric hindrance masking, and proprietary CD3 sequences with fast on/off kinetics to minimize cytokine release syndrome (CRS) and enhance efficacy. These characteristics support the platform’s broad applicability across autoimmune disease, solid tumors and hematological malignancies indications.

To date, Antengene has obtained 31 investigational new drug (IND) approvals in the U.S. and Asia, and submitted new drug applications (NDAs) in 11 Asia Pacific markets. Its lead commercial asset, XPOVIO® (selinexor), is approved in Mainland of China, Taiwan China, Hong Kong China, Macau China, South Korea, Singapore, Malaysia, Thailand, Indonesia and Australia, and has been included in the national insurance schemes in five of these markets (Mainland of China, Taiwan China, Australia, South Korea and Singapore).

Forward-looking statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, please see the other risks and uncertainties described in the Company’s Annual Report for the year ended December 31, 2024, and the documents subsequently submitted to the Hong Kong Stock Exchange.

For more information, please contact:

Investor Contacts: 
Donald Lung
E-mail: Donald.Lung@antengene.com
Mobile: +86 18420672158

PR Contacts:
Peter Qian
E-mail: Peter.Qian@antengene.com
Mobile: +86 13062747000