CAMBRIDGE, Mass., ROTTERDAM, Netherlands and SHANGHAI, Oct. 28, 2025 /PRNewswire/ — Harbour BioMed (HKEX: 02142), a global biopharmaceutical company focused on the discovery and development of novel antibody therapeutics in immunology and oncology, today announced the launch of its first fully human Generative AI HCAb (Heavy Chain-Only Antibody) Model powered by its Hu-mAtrIx™ AI platform, built upon the Harbour Mice^® platform. This platform establishes a closed-loop process integrating AI design, intelligent screening, and wet-lab validation.

The announcement was made at the company’s Global R&D Day 2025 event in Shanghai.  During the event, the Global AI + Pharmaceutical Ecosystem Alliance was also officially launched. The alliance brings together leading expertise, cutting-edge technologies, and resources from various sectors, aiming to systematically reshape the entire drug R&D process through artificial intelligence technologies, accelerating the development of innovative therapies for the benefit of patients worldwide.

AI-Driven Precision for Faster and More Accurate Target Identification

The newly released AI HCAb Model establishes a closed-loop workflow that integrates AI-driven sequence generation, design and screening, and wet-lab validation. This end-to-end process transforms antibody discovery from blind screening to AI-driven intelligent selection, dramatically improving efficiency and accuracy in antibody discovery.

HCAb, known for its simple structure and low molecular weight, holds strong potential for advanced applications like bispecific/multi-specific antibodies, ADCs, CAR-T, and mRNA therapies. However, conventional human VH domains struggle to maintain stability without VL pairing. 

Harbour BioMed’s Harbour Mice^® platform — the world’s first transgenic mouse platform that produces fully human functional HCAb — laid the foundation for overcoming this challenge. The key AI design lies in accurately identifying functional, autonomous HCAbs from vast datasets, given the high structural and sequential similarity between HCAb VH sequences and those of conventional (H2L2) antibodies. Harbour BioMed’s HCAb generation model is trained on 9 million NGS-derived HCAb sequences and extensive public data. Using a fine-tuned protein large language model, it enables de novo generation of high-potential HCAb sequences, with secondary optimization for target specificity. 

These AI-generated sequences then undergo a multi-stage intelligent screening process, which includes:

• AI Classification Model to filter non-HCAb sequences
• Multimodal AI Developability Prediction Model (achieving SOTA performance) to assess key developability parameters such as stability, solubility, and aggregation tendency

Only candidates that pass rigorous screening proceed to synthesis and wet-lab validation.

AI HCAb Model Delivers Higher Binders Diversity and Binding Success Rate

The AI HCAb Model demonstrated a tenfold increase in candidate generation and significantly improved success rates. Data show that among 107 de novo generated binder sequences produced by AI HCAb model, 78.5% successfully hit the target, while 20 molecules were further validated in wet-lab assays, demonstrating high activity, purity, yield, and specificity.

These AI-designed binders demonstrated outstanding developability profiles, with an average yield exceeding 700 mg/L. Multiple candidate sequences showed nanomolar-level binding affinity while maintaining binding activity against relevant targets in both humans and cynomolgus monkeys.

Accelerating the Development of Next-Generation Therapies

Harbour BioMed’s AI platform is designed as a self-evolving innovation flywheel driven by continuous learning and feedback: AI design – automated validation – AI re-learning.

This iterative process enables generative AI to create diverse new molecules, while high-throughput automation rapidly characterizes and feeds back experimental data to continuously enhance model intelligence and R&D efficiency.

With this foundation, the AI HCAb Model is expected to accelerate applications of fully human HCAbs across next-generation therapeutic areas — including multi-specific antibodies, XDCs, in vivo CAR-T, and inhaled or oral large-molecule drugs — helping redefine the landscape of biologics discovery.

Building the Future AI + Pharmaceutical Ecosystem

At the event, Harbour BioMed also announced the official establishment of the Global AI + Pharmaceutical Ecosystem Alliance, which brings together leading experts, technology partners, and investors to reshape the entire drug discovery pipeline through AI innovation.

The alliance has gained strong support from government bodies, industry associations, and investors including Fortera Capital, Insilico Medicine, Molecular Mind, Evinova, INNOVEL, Fenglin Group, Taimei Technology, EClinCloud, Deep Intelligent Pharma, and Harbour BioMed.

Dr. Jingsong Wang, Founder, Chairman, and CEO of Harbour BioMed, said: “The Global AI + Pharmaceutical Ecosystem Alliance aims to create an open, collaborative, and win–win ecosystem. Through shared value and collective innovation, we seek to address the toughest challenges in drug discovery and bring transformative therapies to patients faster and more effectively.”

About Harbour BioMed

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics in immunology and oncology. The company is building a robust and differentiated pipeline through internal R&D capabilities, strategic global collaborations in co-discovery and co-development, and selective acquisitions.

Harbour BioMed’s proprietary antibody technology platform, Harbour Mice^®, generates fully human monoclonal antibodies in both the conventional two heavy and two light chain (H2L2) format and the heavy chain-only (HCAb) format. Building upon HCAb antibodies, the HCAb-based immune cell engagers (HBICE^®) bispecific antibody technology enables tumor-killing effects that traditional combination therapies cannot achieve. Additionally, the HCAb-based bispecific immune cell antagonist (HBICA^TM) technology empowers the development of innovative biologics for immunological and inflammatory diseases. By integrating Harbour Mice^®, HBICE^®, and HBICA^TM with a single B-cell cloning platform, Harbour BioMed has built a highly efficient and distinctive antibody discovery engine for developing next-generation therapeutic antibodies. For more information, please visit www.harbourbiomed.com.

MILPITAS, Calif., Oct. 28, 2025 /PRNewswire/ — Global shipments of silicon wafers are projected to increase 5.4% in 2025 to 12,824 million square inches (MSI) followed by steady growth through 2028 when the market is expected to reach a new industry record of 15,485 MSI, SEMI reported today in its annual silicon shipment forecast.

In 2025, the increase in silicon wafer shipments has been supported by strong AI-related growth, including advanced epitaxial wafers for leading edge logic devices and polished wafers for high bandwidth memory (HBM). Wafer shipments for non-AI applications, however, are just beginning to demonstrate a gradual recovery from the recent downcycle. The steady growth is expected to continue through 2028, driven by AI’s expanding compute footprint in data centers and at the edge.

Global Silicon Wafer Shipments Forecast, 2022-2028F

Silicon wafers are the fundamental building material for the majority of semiconductors, which are vital components of all electronic devices. The highly engineered thin disks, produced in diameters of up to 300 mm, serve as the substrate material on which most semiconductor devices, or chips, are fabricated.

All data cited in this release include polished silicon wafers and epitaxial silicon wafers shipped by wafer manufacturers to end users. The data does not include non-polished or reclaimed wafers.

The annual silicon shipment forecast is developed based on input from the members of the Silicon Manufacturers Group (SMG). The SMG is a sub-committee of the SEMI Electronic Materials Group (EMG). This forecast reflects industry input gathered by SEMI and does not represent an official forecast of the SMG or any individual member company.

For more information, please visit SEMI Worldwide Silicon Wafer Shipment Statistics, SEMI Market Data or contact mktstats@semi.org.

About SEMI

SEMI^® is the global industry association connecting over 3,000 member companies and 1.5 million professionals worldwide across the semiconductor and electronics design and manufacturing supply chain. We accelerate member collaboration on solutions to top industry challenges through Advocacy, Workforce Development, Sustainability, Supply Chain Management and other programs. Our SEMICON^® expositions and events, technology communities, standards and market intelligence help advance our members’ business growth and innovations in design, devices, equipment, materials, services and software, enabling smarter, faster, more secure electronics. Visit www.semi.org, contact a regional office, and connect with SEMI on LinkedIn and X to learn more.

Association Contacts
Sherrie Gutierrez/SEMI Corporate
Phone: 1-831-889-3800
Email: sgutierrez@semi.org

Stephanie Quinn/Kiterocket (Media Inquiries)
Phone: 1-480-316-8370
Email: squinn@kiterocket.com

New software simplifies programming and configuration for Micro800 controllers 

MILWAUKEE, Oct. 28, 2025 /PRNewswire/ — Rockwell Automation, Inc. (NYSE: ROK), the world’s largest company dedicated to industrial automation and digital transformation, today announced the launch of FactoryTalk^® Design Workbench™, a free design software built specifically for micro control systems. Version 1 supports Micro800™ controllers and provides a unified workspace for programming, configuration and troubleshooting. 

Rockwell Automation launches FactoryTalk Design Workbench, a free software tool for building micro control systems smarter and faster

FactoryTalk Design Workbench software gives machine builders and manufacturers working on compact, standalone systems a consistent and efficient way to develop automation solutions. Companies in packaging, water and wastewater, agriculture and material handling often face long development cycles, fragmented tools and limited flexibility. The new software streamlines the process from programming to deployment while supporting multiple devices at once to simplify system management.

Key features in version 1 capabilities include: 

• Modern design environment with a consistent Logix experience for faster onboarding
• Improved download speed and online workflows for greater efficiency
• Multi-device support for Micro810^® and newer Micro800 Lx0E controllers allowing easy access to multiple controllers at the same time to simplify troubleshooting

“FactoryTalk Design Workbench software is our next-generation design environment for micro control systems, delivering a productive, more reliable and familiar experience for users of Rockwell Automation products,” says Wan Shan Loo, product manager at Rockwell Automation. “Customers have asked for something intuitive and easy to use, and FactoryTalk Design Workbench software delivers. With support for Micro800 controllers and a scalable architecture, it simplifies workflows and lays the foundation for broader device integration in the future.” 

FactoryTalk Design Workbench software is available now through Rockwell’s Product Compatibility & Downloads Center (PCDC). Future versions are planned to expand support beyond Micro800 controllers, with annual updates expected.  

Visit Rockwell’s website to learn more, or register to attend for Rockwell’s Automation Fair^® event, taking place at McCormick Place in Chicago from Nov. 17-20, to get a first-hand experience of the new software through hands-on labs and technical sessions.

About Rockwell Automation
Rockwell Automation, Inc. (NYSE:  ROK), is a global leader in industrial automation and digital transformation. We connect the imaginations of people with the potential of technology to expand what is humanly possible, making the world more productive and more sustainable. Headquartered in Milwaukee, Wisconsin, Rockwell Automation employs approximately 27,000 problem solvers dedicated to our customers in more than 100 countries as of fiscal year end 2024. To learn more about how we are bringing the Connected Enterprise® to life across industrial enterprises, visit www.rockwellautomation.com.

NEW YORK, Oct. 28, 2025 /PRNewswire/ — LILYSILK, world’s leading silk brands with a mission to inspire people to live a better life and a more sustainable lifestyle, has officially launched its 2025 Black Friday Sale. The sale, which began October 27, highlights the brand’s signature blend of craftsmanship, comfort, and eco-conscious design, and expresses heartfelt thanks to its global community.

Among this year’s featured pieces is the Ultra-Soft Brushed Cashmere Cardigan, made from 100% Grade A Mongolian cashmere and brushed using advanced Japanese techniques. Its cloud-soft texture and polished silhouette make it a layering essential that moves effortlessly from workdays to weekends.

The Worry-Free Wool Skirt redefines woolwear with machine-washable practicality. Designed to flatter all body types, its breathable stretch knit and fluid silhouette offer comfort without compromise and are perfect for office wear or casual elegance.

LILYSILK’s innovative Heirloom ’89 Zip Jacket also joins the lineup. It’s crafted from SILKERRY™, a proprietary terry fabric featuring 100% natural silk loops that touch the skin, offering instant softness, temperature regulation, and moisture-wicking performance. This two-way zip jacket delivers relaxed structure and elevated style in every wear.

Celebrity-loved items are also part of the sale. Selena Gomez was recently spotted in the Tailored Silk Shirt, a crisp, slim-cut essential made from machine-washable silk, perfect for modern professionals seeking elegance and ease. In her music video Sunset Blvd, she wore the Brushed V-Neck Cashmere Sweater, featuring plush Mongolian cashmere and a softly tailored cinched waist.

Jasmine Tookes, an American fashion model, shared her look featuring the Silk Charmeuse Crewneck Blouse and Full Bias Cut Silk Pants. These pieces are crafted from double-faced 100% silk charmeuse and cut to drape effortlessly, embodying polished minimalism with every movement.

Additional deals include up to 25% off ready-to-wear favorites, up to 60% off selected collections, and a “Buy One, Get One 50% off” offer on select silk pillowcases.

“This season of gratitude, we extend our deepest thanks to our community,” said David Wang, CEO of LILYSILK. “The trust of our customers inspires our continued pursuit of excellence, where the finest materials are honored through mindful creation and every piece is crafted to stand the test of time.”

These exclusive offers are available while supplies last, offering up to 60% off on a curated collection of luxurious fashion and home essentials. Explore the full selection and discover more at www.lilysilk.com.

In Partnership with the International League of Dermatological Societies (ILDS) and the International Society of Dermatology (ISD), CeraVe Mobilizes 9 Countries to Expand Access to Dermatological Care Worldwide

NEW YORK, Oct. 28, 2025 /PRNewswire/ — To address the global skin health crisis that leaves billions without access to a dermatologist, CeraVe, the #1 dermatologist-recommended skincare brand in the U.S.*, reached over 3,900 patients around the globe through World Skin Health Day initiatives this summer.

CeraVe World Skin Health Day

World Skin Health Day is led by the International League of Dermatological Societies (ILDS) and the International Society of Dermatology (ISD). Taking place on 8 July each year, it delivers education on the significance of skin health and encourages discussions and actions that contribute toward improving skin health around the world. As the day’s official corporate partner for the second year, CeraVe worked with the ILDS and ISD to build on the achievements of 2024, activating in 9 countries, in addition to amplifying awareness around the world.

Raising Global Awareness for a Skin Health Crisis
While one-third of the global population is affected by skin disease, there is less than 1 dermatologist per million people in some countries, creating a coverage gap that leaves 3 billion without access to care.^1-3 Through its partnership with ILDS and ISD, CeraVe is on a mission to help close the gap and ensure that more patients worldwide can access dermatological expertise.

Individuals and organizations from 76 countries participated in sharing campaign messages for World Skin Health Day, their stories and activities to raise awareness on social and digitally, contributing to a reach of more than 4.5 million, which included a global awareness initiative at CeraVe’s 20^th Birthday event.

Timed to its 20^th anniversary, the brand also hosted a global celebration of two decades of skincare on World Skin Health Day. Top dermatologists and creators came together to learn about accessible dermatological solutions and the CeraVe commitment to improving skin health worldwide.

Impact at a Glance

• 9 countries activated across 5 continents
• 3,900+ underserved patients treated
• 4.5M+ people reached online and in person
• 200+ government officials pledged support for skin health advocacy

Mobilizing Care within the US and Around the Globe
Additionally, there were 11 in-country events spanning government advocacy, healthcare education and patient care, including:

• Indonesia: over 220 patients received dermatological care and more than 60 government officials pledged support for skin health.
• Nigeria: more than 1,200 patients accessed dermatological services for the first time.
• Bangladesh: mobile dermatology units reached remote, flood-prone areas to diagnose and treat over 1,000 patients.
• Philippines: Nearly 50 dermatologists and healthcare workers served 163 patients in a remote community and trained 136 other healthcare workers.

Within the United States, CeraVe teamed up with its partner, the National Association of Free and Charitable Clinics (NAFC), to bring skin health to the forefront of underserved and under-resourced communities. Around the country, dermatologists volunteered their time at NAFC clinics to see patients, while L’Oreal Skin Health Advisors led educational sessions in other clinics. On World Skin Health Day and beyond, the CeraVe and NAFC partnership impacted hundreds of patients and volunteers, inspiring long-term action.

“Our ongoing partnership with CeraVe has brought tremendous value to our clinics, from providing educational opportunities for volunteers to expanding the scope of care we can offer our patients,” said Ariana Gordillo, Senior Director at NAFC. “We know that access to skincare and skin resources is both limited globally and within our own communities, so having a partner like CeraVe allows us to grow our offerings and deliver meaningful care to patients across the country.”

Prof. Henry W. Lim, ILDS President, said: “Once again, this year’s World Skin Health Day highlighted the profound impact of skin diseases on billions of people and their families worldwide, while also delivering vital education and shining a light on the urgent need for greater access to dermatological care.

“Thanks to CeraVe Care For All’s generous partnership, we were able to fund 9 inspiring initiatives in underserved regions across the globe — each making a meaningful difference to skin health in communities that need it most. We are deeply grateful for CeraVe’s continued commitment to advancing skin health equity.”

Championing Skin Health Equity Through Care For All
These initiatives are all part of CeraVe Care For All, a philanthropic program dedicated to improving access to dermatological care in underserved communities around the world and empowering frontline healthcare workers to help millions of underserved patients.

“We at CeraVe have had the privilege to collaborate with extraordinary organizations and leaders who share our deep commitment to expanding access to dermatological care,” said Tom Allison, Senior Vice President of Medical Dermatology Marketing at L’Oreal. “Skin health is a fundamental human right, and supporting initiatives such as World Skin Health Day provides CeraVe a global platform to spark conversation, champion equity and lead the way in enacting meaningful change for all people.”

Supporting World Skin Health Day 2025 was another bold step for CeraVe in breaking down barriers to care and empowering skin health experts. To learn more about CeraVe Care For All and the initiatives happening around the globe, visit https://www.lorealdermatologicalbeauty.com/cerave/care-for-all.

About CeraVe

Founded in 2005 with a mission to provide therapeutic skincare for all, CeraVe creates products developed with dermatologists to restore and maintain the skin’s natural barrier. All CeraVe formulas are enriched with three skin-identical ceramides (ceramides 1, 3, and 6-II), with select products featuring MVE Technology for controlled, long-lasting hydration. CeraVe is the #1 dermatologist-recommended skincare brand in the US* and is now available in over 60 countries worldwide. Find CeraVe on Facebook (@ceraveusa), Instagram (@cerave), TikTok (@cerave), X (@cerave) or visit www.cerave.com.  

About World Skin Health Day

World Skin Health Day is a joint project of the International League of Dermatological Societies (ILDS) and the International Society of Dermatology (ISD). Since 2013, World Skin Health Day has been taking place across the world to raise awareness of and treat a diverse range of skin conditions.

About National Association of Free and Charitable Clinics (NAFC)
The National Association of Free & Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of medically underserved people throughout the U.S. and the more than 1,400 Free and Charitable Clinics and Charitable Pharmacies that serve them. NAFC programs provide a wide range of support to our members and in turn patients through funding, education and training, advocacy, standards, disaster relief and more.

^* IQVIA, ProVoice Survey, rolling 12-month data as of January 2025
¹ Seth D et al. Curr Dermatol Rep. 2017;6(3):204-210.
² Rosenbaum BE et al. Pan Afr Med J. 2017;26:125.
³ Coustasse A et al. Telemed J E Health. 2019;25(11):1022-1032.

CeraVe World Skin Health Day

• A strong focus on people, planet and communities has driven several notable achievements, including carbon neutrality for Scope 1 and 2 emissions, more women in leadership positions and more under-represented groups reached through community STEM education programmes

LONDON, Oct. 28, 2025 /PRNewswire/ — Logicalis, a leading global technology service provider, has announced significant progress in its FY25 Responsible Business Report, demonstrating measurable impact through strategic environmental, social, and community initiatives.

Logicalis FY25 Responsible Business Report

Carbon neutrality achieved ahead of schedule
In addition to reducing its Scope 1 and 2 emissions by 10% against FY22 baseline over the last 12 months, Logicalis achieved carbon-neutral status for these emissions in FY25. This has been achieved through a combination of strategic initiatives, including the adoption of renewable energy, the purchase of verified carbon offsets and the implementation of carbon and energy reduction plans by country of operation.

Driving sustainable innovation for customers
Over the last year, Logicalis has also supported customers in achieving their sustainability goals. Key to this has been enhancing the company’s AI-powered Digital Fabric Platform (DFP), which provides customers with real-time insights into their digital ecosystem performance across five key metrics, including sustainability. The platform offers actionable recommendations to reduce power consumption and carbon emissions. Furthermore, the company has provided circular IT solutions, energy-efficient network transformations and smart building integrations.

In recognition of its continued efforts to help customers reduce the carbon impact of their IT infrastructure, Logicalis was named Cisco’s Global Sustainability Partner of the Year for the second year in a row.

Strengthening community impact
Logicalis’ Responsible Business strategy maintained a commitment to diversity, inclusion, and skills development. With total donations of $232,000 across charities and community investments, the company supported over 500 beneficiaries through 21 education-focused community projects.

Initiatives included:

• Logicalis Bursaries, South Africa: 22 scholarships were awarded for STEM qualifications
• Grad Girls, Australia: 40 female graduate students have been mentored and engaged in industry challenges
• Apadrina TIC, Spain: Seven scholarships and mentorship opportunities were given to financially disadvantaged STEM students

Developing future leaders
Employee development also remained a priority. In FY25, female representation in Logicalis’ senior leadership roles increased from 29% to 34% and the female succession pipeline increased from 17% to 29%. Additionally, 210 colleagues participated in leadership programs, alongside the launch of the first global Learning Management System, delivering 1,651 days of learning.

Bob Bailkoski, CEO of Logicalis, said: “A commitment to Responsible Business lies at the heart of our organisation. We have achieved carbon neutrality ahead of schedule, proving that sustainability and commercial growth go hand in hand. Alongside this milestone, we are proud to have increased female representation in our leadership teams and delivered some exceptional grassroots educational projects. These achievements reflect a real-world impact for the planet, our people and the communities we serve.

“As we continue to grow, it becomes even more important that we stay committed to being a force for good. In a world where technology is accelerating at pace, we want to make sure everyone has an opportunity to be on the journey, which is why we’re expanding our community initiatives. We’re also doubling down on our focus on energy efficiency and accelerating the adoption of renewable energy. As we drive further into the AI era, it’s more important than ever that progress happens consciously and responsibly.”

Underpinning all of these achievements is Logicalis’ comprehensive Responsible Business governance framework. Global councils make recommendations through parent company Datatec’s oversight structure, ensuring balanced decision-making that considers environmental, social, and profitability impacts while addressing the needs of all stakeholders – employees, customers, suppliers, nature, and local communities.

Read the full Logicalis Responsible Business Report FY25: www.logicalis.com/our-responsible-business

About Logicalis
We are Architects of Change™. We help organisations succeed in a digital-first world. At Logicalis, we harness our collective technology expertise to help our clients build a blueprint for success, so they can deliver sustainable outcomes that matter.

Our lifecycle services across cloud, connectivity, collaboration and security are designed to help optimise operations, reduce risk and empower employees.

As a global technology service provider, we deliver next-generation digital managed services, to provide our clients with real-time visibility and actionable insights across the performance of their digital ecosystem including reliability, user experience, security, economic performance and sustainability.
Our 7000+ ‘Architects of Change’ are based in 30 territories around the globe, helping our 10,000+ clients across a range of industry sectors, create sustainable outcomes through technology.

Logicalis has annualised revenues of $1.63 billion, from operations in Europe, North America, Latin America, Asia Pacific, and Africa. It is a division of Datatec Limited, listed on the Johannesburg Stock Exchange, with revenues of over $3.6 billion.