Drives Partnerships to Enhance Network for Greater Agility and Customer Convenience
SingPost’s service touchpoints expands to 2500

SINGAPORE, Oct. 19, 2025 /PRNewswire/ — Singapore Post Limited (SingPost) is strategically positioning its national delivery infrastructure to enhance community convenience and grow its touchpoints to meet changing consumer demands.

The Company shared its network approach in building a pervasive islandwide network focusing on increased convenience for customers. This approach, leverages key partnerships for scale, expands SingPost’s service touchpoints to over 2,500, ensuring that 80 per cent of Singapore’s population can reach a SingPost touchpoint within 10 minutes or less.

Enhancing Community Mail Services with SingPost@MyBlock Trial

The company today announced the launch of SingPost@MyBlock, a new Residential Posting Box Trial, which will be officiated by Deputy Prime Minister Gan Kim Yong on 19 October 2025.

Through the SingPost@MyBlock trial, residents can conveniently post and return mail directly at their residential letterbox nest. Dedicated slots or additional boxes will be clearly marked, enabling residents to send mail easily within their own estate.

The trial will begin across 27 housing blocks in the Punggol Northshore District. In the next few weeks, the trial will be further expanded to a total 226 blocks across 5 districts which include Punggol, Marine Parade, Upper Boon Keng, Bukit Panjang and Bukit Batok. The trial will run through to the end of December 2025. A successful pilot here will inform a full island-wide rollout, converting approximately 21,000 letterbox nests in residential estates, improving public convenience.

Neo Su Yin, Group Chief Operating Officer of SingPost said, “We are leveraging every touchpoint we have—from the letterbox nest in the heartland to expanding our partnerships — to serve both the postal sector and the growing eCommerce market. By piloting SingPost@MyBlock, we enhance community convenience, and through our strategic partnerships, we are building an agile network that delivers greater convenience for customers. This cohesive approach ensures we work to grow our position as Singapore’s leading national end-to-end logistics provider.”

Strategic Partnership with PICK Network for Greater eCommerce Access

Further expanding its eCommerce reach, SingPost today also announced the integration of Pick Network Pte Ltd (Pick)’s locker network into its last-mile infrastructure.

SingPost will incorporate Pick’s 1,084 Pick lockers – situated in HDB estates, community centres, transport hubs, and other convenient locations – to SingPost’s last-mile infrastructure. These Pick lockers offer 24/7 access for parcel collection.

This significant expansion complements SingPost’s existing network of POPDrop kiosks and Parcel Santa lockers, creating a pervasive network for eCommerce. SingPost will consolidate mail and parcels, delivering into Pick Lockers as part of regular letterbox rounds, ensuring operational sustainability.

This integration directly benefits customers of major eCommerce platforms and marketplace sellers, providing them with enhanced delivery flexibility and convenience during the checkout process. Lazada, a SingPost customer, is on board and shoppers on the eCommerce platform will have the ability to select delivery to a Pick Locker of their choice.

“We are pleased to partner with SingPost in integrating the Pick Locker network, a meaningful step towards offering shoppers in Singapore with more flexible and convenient delivery choices. By enabling customers to select Pick Lockers as a delivery option directly at checkout, we are empowering them with greater control over how and when they receive their parcels. Enhancing last-mile convenience is a key part of Lazada’s commitment to creating a seamless and trusted eCommerce experience for our customers,” said James Liu, Chief Logistics Officer, Lazada Group.

Building a pervasive eCommerce network in Singapore

SingPost’s pervasive reach is further achieved through:

• Heartland Drop-off Points: The POPStop drop-off service, which records an average of 180,000 parcel drop-offs per month, has recently been expanded to include over 160 staffed Cheers^[1] and FairPrice Xpress outlets across Singapore. This provides additional service points for eCommerce shipping and convenient purchase of SingPost’s pre-paid smartpac packaging and pre-paid labels.
• Global Logistics Partnerships: SingPost is maximising the utility of its network by serving major international logistics partners. Both DHL Express^[2] and FedEx^[3] have expanded their parcel drop-off services to all SingPost post offices nationwide, leveraging SingPost’s infrastructure for cross-border shipping convenience.

SingPost is solidifying its commitment to Singapore’s logistics future by implementing a network approach designed to make postal and eCommerce services more convenient. This strategy focuses on three core areas: bringing services closer to the public through partnerships, designing simple and accessible infrastructure for hassle-free parcel sending and collection (including the expansion of 24/7 PUDO points), and driving enhancement through initiatives like the SingPost@MyBlock trial to enhance residents’ convenience directly at their letterbox nests.

About Singapore Post Limited (SingPost)

Singapore Post (SingPost) is a leading postal and eCommerce logistics provider in Asia Pacific. The portfolio of businesses spans from national and international postal services to warehousing and fulfilment, international freight forwarding and last mile delivery, serving customers in more than 220 global destinations. Headquartered in Singapore, SingPost has approximately 3,000 employees. Since its inception in 1858, the Group has evolved and innovated to bring about best-in-class integrated logistics solutions and services, making every delivery count for people and planet. www.singpost.com 

AMT-253 is a potential first-in-class MUC18-directed ADC with a proprietary linker-payload design  

AMT-253 demonstrated a manageable safety profile, consistent with other TOP1-inhibitor based ADCs

Promising antitumor activity was observed in heavily pretreated patients with melanoma and gynecologic cancers without MUC18 preselection

SHANGHAI, Oct. 19, 2025 /PRNewswire/ — Multitude Therapeutics, Inc., a clinical stage biopharmaceutical company focused on the development of ADC drugs, today announced interim results from its ongoing Phase I/II open-label, multicenter dose escalation and expansion study evaluating AMT-253, a MUC18-directed antibody-drug-conjugate (ADC), in patients with melanoma and other advanced solid tumors. The data are being presented on October 19th at the 2025 European Society for Medical Oncology (ESMO) Annual Meeting being held in Berlin, Germany.

Phase I/II clinical trials are ongoing in both Australia and China. This first-in-human study will evaluate the Maximum Tolerated Dose (MTD) / the Recommended Phase II Dose (RP2D), safety, tolerability, anti-tumor activity, pharmacokinetics, pharmacodynamics and immunogenicity of AMT-253, in patients with advanced solid tumors. The Phase Ia portion will determine the recommended doses for expansion, and the Phase Ib/II portion will focus on further characterizing safety and efficacy in select tumor types.

As of September 8th, 2025, safety data are available for 170 patients who have received AMT-253 once every three weeks (Q3W) at doses ranging from 1.6 to 5.6 mg/kg. Primary tumor types are melanoma, endometrial cancer, cervical squamous cancer and uterine leiomyosarcoma. In heavily pretreated melanoma patients, with prior lines of therapy ranging from 1-7, promising efficacy was observed without MUC18 preselection. The overall response rate (ORR) was 28.6% in all melanomas (16/56, 15 confirmed, 1 unconfirmed still on-treatment) across all dose levels. In melanoma patients without prior chemotherapy, ORR was 35% (7/20, all confirmed), 50% (5/10; 4 confirmed, 1 unconfirmed still on-treatment), and 33.3% (1/3, confirmed) for the cutaneous, acral, and mucosal subtypes, respectively; preliminary mPFS was 8.6, 8.3, and 11.0 months. Among 18 cutaneous melanoma patients at the potential expansion doses, ORR was 38.9% (7/18, all confirmed), and preliminary mPFS was 8.6 months. Preliminary antitumor activity was also observed in endometrial cancer, cervical squamous carcinoma and uterine leiomyosarcoma patients. Responses were observed across MUC18 expression levels in all tumor patients evaluated. AMT-253 showed a safety profile consistent with other topoisomerase-1 (TOP1) inhibitor–based ADCs, with manageable hematologic toxicities as the most common treatment-related adverse events. No treatment-related cases of neuropathy or pneumonitis were observed as of the data cutoff.

“We are excited by the durable antitumor activity observed in the early clinical results of AMT-253, particularly in unselected, late-line metastatic melanoma patients, where the unmet medical need remains high,” said Dr. Shu-Hui Liu, Co-founder and CSO of Multitude Therapeutics. “These initial data, together with our previously published preclinical findings*, highlight the potential of AMT-253 to offer meaningful outcome improvement to patients who have exhausted standard-of-care options. We look forward to further clinical confirmation of these results and to fully exploring the potential of this novel ADC for greater patient benefit.”

*Shi et al., (2023) Cancer Research 83:3783-95

Poster Presentation Details:

Title: Ongoing Phase I trial results of AMT-253, a first-in-class MUC18-targeting antibody-drug conjugate in patients with melanoma and other advanced solid tumors
Session Title: Developmental therapeutics
Date and Time: October 19th – 09:00-17:00
Poster Number: 997P
Location: Hall 25, Level 2

About AMT-253

AMT-253, a MUC18 ADC, is composed of a proprietary antibody with high MUC18 binding affinity, a protease-cleavable linker, and an exatecan payload (a potent and clinically validated topoisomerase-1 inhibitor). The linker is designed to complement the exatecan payload, enabling a stable and homogenous ADC. The payload is a weak substrate for BCRP/P-gp, which are drug efflux pumps that drive chemoresistance to many therapies. In preclinical data, this linker-payload has been shown to have an increased “bystander effect” compared to the equivalent of competitor ADCs**. AMT-253 has a drug-to-antibody ratio of eight. AMT-253 is being evaluated in a Phase I/II study in patients with melanoma and other advanced solid tumors. Additional information on the AUS PhI(NCT05906862) and China PhI/II (NCT06209580) trials can be found at clinicaltrials.gov.

** Weng et al., (2023) Cancer Discovery 13:950–73

About Multitude Therapeutics

Multitude Therapeutics is a clinical-stage company focused on the development of ADC drugs. Multitude Therapeutics utilizes two technology platforms: MabArray™— an antibody platform for discovering novel cell surface tumor antigens to identify first-in-class targets, and T1000- exatecan — a new linker-payload technology for developing ADCs, which allows ADCs prepared with this platform to achieve a better balance of the bystander effect, efficacy, and safety. The combination of MabArray™ and T1000-exatecan generates significant synergistic effects, enabling Multitude Therapeutics to build an ADC “atlas” that is expected to treat malignant tumors with high unmet medical needs and achieve higher and more durable responses.

Based on the above technology platforms, Multitude Therapeutics currently has several ADCs in development, including three potential first-in-class target ADCs. Moreover, several ADCs, including all-new target ADCs, have entered the clinical stage, where they have demonstrated promising safety and efficacy and provided preliminary validation of the company’s platform technology. For further information, please visit www.multitudetherapeutics.info

Contact:

Multitude company email
info@multitudetherapeutics.com 

Look Up Hong Kong-Ipsos survey of 651 parents backs a four-part plan for kids’ wellbeing: delayed access to smartphones and social media, phone-free schools and more real-world activity and experiences. 

HONG KONG, Oct. 19, 2025 /PRNewswire/ — Look Up Hong Kong, a new parent-led group launched to unite families for healthier, happier childhoods in the digital age, is leading a movement to advocate for delayed smartphone and social media use. The movement is backed by a growing global body of medical research, and now by Hong Kong data showing overwhelming support from local families concerned about the impact of early digital device use on their children’s wellbeing.

Look Up Hong Kong, a registered non-profit society, has officially launched today, advocating for delaying smartphones until age 14 and social media until 16. The movement kicks off with a survey of 651 Hong Kong parents that revealed widespread problems with smartphone and social media use.

“Hong Kong parents struggle with their own smartphone and social media use. Over 75% say they can’t live without their phones, with two-thirds admitting they spend too much time on them, impacting their wellbeing, work, and lifestyle,” said Robert Broad, Look Up Hong Kong founder.

“They want different for their children,” Broad said. “More than half agree that smartphones and social media negatively affect their child’s wellbeing, and 84% agreed that delaying social media until at least 16 years would benefit both the mental and physical wellbeing of their kids. Their main concerns for their kids are online safety threats, physical and mental health risks, impact on academic performance, and addiction potential.

Look Up Hong Kong prioritizes its activities and recommendations across four pillars:

1.       Delay smartphones to at least 14 years, to give children critical brain-development time before facing unlimited internet access and constant alerts ^{[1, 2]}.

• Three-quarters of parents in the survey support the age-14 target.

2.       Delay social-media use to at least 16 years; early social media is linked to spikes in anxiety, body-image issues and cyber-risk exposure ^[3].

• Around two-thirds of HK parents back a 16-plus start.

3.       Advocate for smartphone-free schools and activities—Removing phones for the school day improves attention, peer connection and academic performance ^[4-8].

• 89% of respondents support restrictions on smartphones in schools.

4.       Support outdoor activities, free play and real-world experiences to strengthen agency, social skills, resilience and self-governance ^[9].

• Many HK kids (34%) get just one (or no) opportunity for outdoor activity a week, outside of school.

“Smartphones and social media are designed to capture attention—if adults struggle to manage their use, what chance do children have?” said Sara Lam, a clinical psychologist managing problematic smartphone use, and Look Up Hong Kong advisor. “These technologies drive family conflict, with over 80% of parents experienced arguments over usage in the past, and expose kids to serious risks – 25% have been contacted by strangers, and 13% of children aged 6-10 have encountered inappropriate adult content.”

Despite these concerns, essentially all children (98%) have a smartphone by 14 years (52% of those aged 6-10 years; 86%, aged 11-13 years), with the average age of first smartphone ownership at just 9 years.

Tanya Strongman of Look Up Hong Kong, explained, “This movement arose from parents’ need for support and shared frustrations. In focus groups, parents repeatedly expressed feeling unprepared to tackle digital challenges alone and overwhelmed by the pressure to give their children smartphones because ‘everyone else has one’.”

To address this pressure, Look Up Hong Kong has launched a city-wide Parent Pact, covering Hong Kong’s more than 1,000 primary and secondary schools. The pact is an online agreement parents can sign to show their commitment to delaying smartphones and social media for their children. Parents can see how many others have signed the pact in their school and class and can use their school community to connect with like-minded parents. “In our survey, more than 85% of parents expressed interest in joining the Parent Pact, and we already have pacts running in over 80 schools across Hong Kong,” Strongman said. “The more parents who join, the stronger the impact. Knowing a pact exists in your child’s class transforms the conversation you can have as a family around delaying smartphones.” (Parents can access the pact on the Look Up Hong Kong website: www.lookup.hk)

Dr. Vivian Mark, a pediatrician and advisor to Look Up Hong Kong, said, “In our daily practice, we see the impact on mental wellbeing (sleep deprivation, anxiety, depression, compromised attention, issues with behavioral and emotional regulation, and eating disorders) and on physical health (obesity, musculoskeletal disorders, lack of activity, and eye complaints and myopia). This effort isn’t about rejecting technology — it’s about protecting critical developmental years for the current and future health of our children.”

Advisor to Look Up Hong Kong, Thomas Chiu, a professor of digital futures, and AI in education, at the Chinese University of Hong Kong, said, “Helping students thrive in life and academics requires an age-appropriate and intentional approach to the introduction of technologies. We must emphasize foundational aspects of education first, and teach kids how to learn independently, think critically, and understand the appropriate role and use of tech in their education and learning. Offline activities are essential, both in and out of the classroom, and children should be encouraged to explore hobbies, stay active, interact with others in the real world and build well-rounded, healthy lifestyles and relationships.”

“Families deserve real choices, not pressure,” said Jeannie Leung of Look Up Hong Kong. “Tech should be an aid to children’s development, not something that consumes their entire attention. When parents are informed and united, delaying smartphones and social media becomes easier, so no child feels left out. In this, parents and caregivers need support to model healthy tech habits and make confident, informed decisions.”

“As they say, it takes a village to raise a child,” Broad said. “We need the entire community to help our kids thrive in the digital future. We call on the government to provide more outdoor spaces and facilities for our children and to regulate platforms (including effective age verification) to protect our kids from harmful tech and content. We call on healthcare professionals to update practice guidelines and parental counsel to reflect the latest research and medical evidence on digital media exposure and child development. We call on schools to partner with parents to create environments where kids can learn and socialize, free from the stresses of smartphones and social media. Finally, we call on parents and the community to model mindful tech use, teaching kids to see technology as a tool for good, not just distraction.”

References:

Look Up Hong Kong-Ipsos Survey Summary

A representative cross-section of Hong Kong parents with school-age children

• 651 parents of Hong Kong school children
• 74% from public schools, 14% from private international/direct subsidy schools, 12% from international schools (including ESF schools)
• Children aged 6-16 years (55% aged 6-10, 29% aged 11-13, 16% aged 14-16)
• The survey was conducted in July 2025.

Parents struggle with their own smartphone and social media use

• Two-thirds of parents feel they spend too much time on their smartphones.
• More than three-quarters say they cannot live without their smartphones.
• Parents reported several negative issues related to their own smartphone use:

–     67% have physical health problems (eyestrain, weight gain, lack of exercise, and musculoskeletal pain)

–     51% have mental/emotional health problems (sleep deprivation, attention difficulties and anxiety/depression)

–     41% have experienced scams, risk of identity theft, and unauthorized transactions

–     38% report a negative impact on work performance, and worries about potential addiction

–     38% reported avoiding social interactions, and an increase in family/relationship conflict

–     29% have experienced online harassment or threats and exposure to harmful content

Parents feel the negative effects of early smartphone and social media use outweigh the positives for their children

• More than half of Hong Kong parents believe smartphones and social media negatively impact their child’s overall wellbeing. This belief is as high as 85% among international school parents.80
• Top parental concerns

1.    Online safety threats
2.    Physical health risks
3.    Academic performance and addiction concerns

• According to parents, the social media platforms that pose the greatest threat to children’s wellbeing are:

1.    TikTok
2.    YouTube
3.    Instagram
4.    Facebook
5.    Xiaohongshu (Little Red Book/ RedNote)

• The top five most used social media platforms for kids are:

1.       Instagram (most popular for junior secondary kids)
2.       YouTube (most popular for primary kids)
3.       WhatsApp
4.       TikTok
5.       WeChat

• On average, more than 45% of children spend 2 or more hours on their smartphones each day (from 25% of lower primary children to 63% of lower secondary children).
• Many kids (34%) get just one (or no) opportunity for outdoor activity a week, outside of school.

Parents are most concerned about online safety for their kids

• Parents worry about cyberbullying, anxiety, depression, and exposure to inappropriate content.
• 12% of children have been exposed to inappropriate adult content online.

–       Boys are almost twice as likely as girls to encounter inappropriate content (15% vs 9%).

• Parents say that 25% of children have been contacted by a stranger online (likely, an underestimate).

–       Boys were 50% more likely than girls to have talked to strangers online.

Parents see the impact of smartphones and social media on relationships and behavior

• 28% of parents consider smartphones and social media harmful to their children’s social relationships. This figure rises to 59% among international school parents.
• More than 80% of parents report conflicts with their kids over smartphone usage.

Despite parental concerns, most children have phones earlier than planned in Hong Kong

• While parents planned to give their children a smartphone at 13 years on average (14 for international schools), the average age that children actually received a smartphone is 9 years (ranging from 2 to 15 years), regardless of school type.
• Over 70% of Hong Kong children already have smartphones.

–       52% of 6–10-year-olds
–       86% of 11–13-year-olds
–       98% of 14-year-olds and up

Most parents believe in the benefits of delaying smartphone and social media use

• 84% agreed that delaying social media until at least 16 years would benefit both mental and physical wellbeing of children in Hong Kong.
• Parents who describe themselves as heavy smartphone users are more likely to support delaying access for their children.

Most parents want stricter smartphone policies in schools.

• 89% of parents support restrictions on smartphones in their kids’ schools.

–       65% want stricter policies than those currently in place in their kids’ school.

–       1 in 5 public school parents would prefer to send their kids to a smartphone-free school.

–       More than 70% of international (mainly primary) school parents would prefer to send their kids to a smartphone-free school.

• The most supported school policies are those that require students to switch off their phones and store them in lockers/bags throughout the school day. The least supported policy is that which allows older students to use their phones but restricts younger students.

Parents support collective action on smartphones and social media

• 73% support delaying smartphone ownership until at least 14 years.
• 64% of respondents support delaying social media access to at least 16 years.
• 85% of respondents would participate in a voluntary parent agreement to delay smartphone access.

About Look Up Hong Kong

Look Up Hong Kong is a grass-roots parent-led movement on a mission to champion childhood and empower parents, carers and educators to protect the mental and physical wellbeing of our children by delaying access to smartphones and social media. We aim to reduce the societal pressure to provide access to these technologies when we know our kids are not ready and allow parents to navigate the digital world according to their values.

An HK-registered non-profit society, Look Up Hong Kong strives to bring families together to stand-up for healthier, happier childhoods. We believe in the importance of kids being kids in the real world, and that technology should be a force for good, that respects our children’s attention, contributes to their wellbeing and helps them flourish.

More Information
Bilingual website: www.lookup.hk
Sign the pact: www.parentpact.lookup.hk

About Ipsos

Ipsos is a global market research leader, operating in 90 markets with nearly 20,000 employees. Our research professionals provide a true understanding of citizens, consumers, and employees through surveys, social media monitoring, and qualitative techniques.