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Walnut Coding Unveils AI-Powered Coding Hardware to Make Programming Tangible for Young Learners at 2025 World Internet Conference

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BEIJING, Dec. 25, 2025 /PRNewswire/ — Walnut Coding (the “Company”), a leading online coding platform for young learners, unveiled its latest generation of AI-powered coding hardware at the 2025 World Internet Conference in Wuzhen, China, held from November 6 to 9. The Company showcased a “Miniature Smart City” and an “AI Programming Smart Car” in a real-world exhibition space to demonstrate how AI knowledge can be turned into practical tools for teenagers. The products drew widespread attention, highlighting what the Company described as a new step forward in the global adoption of practical AI education.

Themed “Forging an Open, Cooperative, Secure and Inclusive Future of Digital Intelligence — Building a Community with a Shared Future in Cyberspace,” the conference addressed topics including the China-proposed Global Development Initiative, digital economy, AI, and data governance. The discussions aimed to explore new approaches to cooperation and governance in the digital age.

Walnut Coding’s exhibition booth featured a “Miniature AI Smart City” powered by its proprietary AI programming controller, which powers and coordinates a range of sensors and actuators. The setup quickly became a focal point for visitors. The product line also included an “AI programming smart car” that recognizes routes and demonstrates intelligent driving fundamentals. It simulates Automated Guided Vehicles (AGVs) moving materials in warehouses, factories, and logistics centers to help teens explore how intelligent factories operate.

These self-operating smart products all rely on the new-generation AI programming intelligent controller independently developed by Walnut Coding. The controller allows smart devices to detect colors, people and objects, respond to spoken prompts, and even play melodies. It also enables teenagers to write code by themselves and control various sensors and actuators, transforming abstract programming concepts into visible AI applications. These engaging and practical models are AI-programmed and interconnected, offering teenagers a clear view of core smart home, transportation, and logistics applications operations.

Zeng Pengxuan, the founder and CEO of Walnut Coding, commented: “True AI literacy isn’t merely about helping a small group of elites master advanced technologies; it’s about giving every child the ability to see, understand, and participate in building intelligent systems. Our goal is to lower the barriers to understanding technology through practical tools, helping young people move from AI users to creators in the future AI world.”

With eight years in the youth programming education sector, Walnut Coding is aiming to build a foundation of AI literacy and skills for teenagers through hands-on programming, helping them shift from AI users to creators in an increasingly technology-driven society. The Company maintains that programming has transcended its role as a purely technical skill and now serves as a fundamental enabler for understanding and advancing artificial intelligence.

As part of its public education efforts, Walnut Coding’s public welfare courses have reached over 40,000 schools across 31 provincial administrative regions and more than 400 cities in China. The initiative has delivered over 800 public training sessions for educators and provided science popularization programs to over 6.6 million students nationwide. Furthermore, it has delivered AI programming training to more than 50,000 primary and secondary school teachers. The Company also became an official UNESCO partner this year, sharing its experience in AI programming education for young learners globally.

Looking ahead, Walnut Coding will continue to empower education with technology, building bridges for more teenagers to enhance their AI literacy, and helping to cultivate more innovative talents who can adapt to the digital intelligence era.

About Walnut Coding

Walnut Coding is a leader in coding education in China. Founded in 2017, The Company offers fun, engaging, and well-structured coding courses for young learners, covering various subjects including Scratch, Python, and C++. Its courses feature adaptive software products with definitive learning objectives and interactive content for learners, as well as individualized guidance from full-time learning assistants throughout the learning process.

Vietnam Is Shining, and Can Gio Is the Hidden Jewel Awaiting Its Moment

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CAN GIO, VIETNAM – Media OutReach Newswire – 25 December 2025 – In 2024, when Hines released its seminal report Why Asia Now, the message was simple yet profound: The world’s most compelling growth story was shifting eastward. At that time, global markets were turbulent but still predictable.

Vinhomes Green Paradise: A Hidden Gem Poised to Shine in Vietnam’s Real Estate Market.
Vinhomes Green Paradise: A Hidden Gem Poised to Shine in Vietnam’s Real Estate Market.

A year later, the landscape has morphed into something far more complex, rippling with tariff shocks, persistent inflation, rising bond yields, and growth downgrades across traditional economic powerhouses. The world feels as if it is moving through a narrow channel, buffeted by waves from every direction. And yet, amid all the noise, Asia has not only held its ground but stepped forward with a clarity and confidence that few regions can match.

Why Asia Now: A New Era of Resilience, Growth, and Opportunity

The forces shaping Asia’s rise have been gathering momentum for decades. What we are witnessing now is their convergence. Asia is not simply adapting to global volatility, it is redefining the foundations of resilience and growth. Its economies are becoming wealthier, stronger, and more self-reliant, and its real estate markets are revealing layers of opportunity that long-term investors have waited years to see.

The near-term picture, though challenged, underscores this resilience. Tariffs have uneven effects, and countries with strong domestic engines such as Australia are absorbing shocks with surprising ease.

But it is the longer horizon that illuminates Asia’s true arc. The region’s working-age population and middle class have expanded at a breathtaking pace, setting the stage for decades of consumption-led dynamism. Education levels are rising, service sectors are flourishing, and manufacturing capabilities are climbing the value chain.

Meanwhile, intra-Asia trade has quietly become the backbone of global commerce, with Asia-to-Asia routes now forming the largest share of world trade. As the region turns inward, not in isolation, but in self-reinforcing collaboration, Asia ex-China is projected to contribute more to global growth than the United States and Europe combined.

Real estate, often seen as a mirror for economic sentiment, is telling a similar story. Transaction volumes across Asia have been less volatile than those in Western markets, and pricing has remained more stable, offering a predictable return profile. Supply constraints, elevated construction costs, and a decade-low pricing position relative to long-term trends are creating what can only be described as an extraordinary entry window.

Why Capital is Flowing into Vietnam

If Asia’s trajectory could be captured in a single idea, it would be the beginning of a Value Uprising, a structural rise in long-term asset worth, powered by demographics, policy, and economic integration, rather than speculation.

From this continental narrative emerges Vietnam, a nation whose ascent is increasingly impossible to ignore. Over the past decade, Vietnam has transformed from a rising star into a gravitational force for global investors. Supply chain diversification has accelerated its role as a manufacturing and logistics nexus. Even with global tariffs shifting, Vietnam’s logistics sector continues to expand in sophistication, efficiency, and international relevance. Its demographic profile, marked by a median age years younger than China, offers a demographic dividend that many Asian economies have already spent. And as Southeast Asia’s digital backbone grows, Vietnam is stepping into the spotlight as one of the region’s next major data-center markets, a signifier of future industrial depth.

Ho Chi Minh City, in particular, has entered a new chapter. Its standing among Asia-Pacific cities for investment and development has climbed steadily, reflecting not only macroeconomic resilience but the confidence of global capital. It has become a symbolic frontier, an emerging metropolis where the contours of modern Asia are being redrawn.

At the heart of Vietnam’s momentum lies another extraordinary phenomenon: The consistent and rising flow of remittances. Vietnam ranks among the world’s top recipients, and Ho Chi Minh City alone welcomed over USD 9.46 billion in 2023, USD 9.6 billion in 2024, and more than USD 5.3 billion in the second quarter of 2025.

A remarkable portion of these funds, around one-fifth, finds its way into real estate. But this is not passive investment. It is a gesture of return, of building a future homeland, of preparing for business, family, and retirement. It is long-term capital with long-term intent.

Vinhomes Green Paradise: A Hidden Gem Poised to Shine in Vietnam’s Real Estate Market

Regulatory reform is reinforcing this trust. The revised Land Law and Real Estate Business Law offer stronger protections and broader rights for Vietnamese citizens, including those living abroad. In a period where global currencies fluctuate and deposit rates decline, investors are increasingly confronting a hard truth: Holding cash is, in many cases, a slow erosion of value. As economist Can Van Luc notes, the VND has lost 3.4 percent of its value in two years, even as the USD depreciated. Real estate, therefore, is not merely an alternative, it has become one of the few asset classes capable of preserving and multiplying value in real terms.

Against this backdrop, regions entering new cycles of infrastructure development are drawing accelerated capital inflows. And among them, one name rises above all others: Can Gio.

For decades, Can Gio stood quietly at the edge of Ho Chi Minh City, an ecological jewel, admired but distant. Today, it has become the most powerful symbol of Vietnam’s coastal urban future. Massive infrastructure investment is reshaping its accessibility, and yet its real estate prices remain a fraction of central districts. Compared to Phu My Hung, Can Gio’s price base is nearly half; compared to Districts 1 and 3, just one-fifth. The gap is not a discount, it is untapped potential waiting to be realized.

The emergence of Vinhomes Green Paradise has pushed this transformation into global consciousness. As the first official participant in the New7Wonders “7 Wonders of Future Cities” campaign, the project is channeling the same catalytic energy once witnessed in iconic developments. Internationally, such recognitions do not merely elevate prestige, they accelerate valuation cycles, attract global capital, and redefine a city’s future skyline.

With its one-of-a-kind geographic formation and proximity to Can Gio’s million-year-old biosphere reserve, Vinhomes Green Paradise stands as a once-in-a-century asset. It embodies scarcity in its purest form, an asset class that cannot be replicated, reshaped, or reborn elsewhere.

And that is where the narrative converges. Asia’s rise, Vietnam’s momentum, Ho Chi Minh City’s evolution, and Can Gio’s emergence are not isolated stories. Together, they form a new investment epoch characterized by structural uplift, demographic acceleration, and a rapidly expanding middle class. It is the era of the Value Uprising, a phase in which the forces of economics, policy, population, and global capital align to propel real estate into a new price horizon.

In moments like this, markets rarely wait. History shows that investors who move early define the benchmark for everyone who follows. The question is no longer whether Asia will rise, or whether Vietnam will lead, or whether Can Gio will transform. The question, now, is whether investors will seize a moment that may not return for another generation.

Sources:

https://www.hines.com/asia-real-estate-opportunity-in-the-midst-of-uncertainty

https://knowledge.uli.org/-/media/files/emerging-trends/2026/emerging-trends-in-real-estate-2026-asia-pacific-report.pdf?rev=2036660434a44fa982b1ba913ffc2a2a&hash=87D5584C38EA219C1F1A50DC8E04FC7B

Hashtag: #Vinhomes

The issuer is solely responsible for the content of this announcement.

Tuya Smart Launches “Hey Tuya:” A Super AI Life Assistant Bringing Physical AI to Everyday Life

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  • Is the real-life J.A.R.V.I.S AI assistant from Marvel’s Iron Man movies almost here?

HANGZHOU, China, Dec. 25, 2025 /PRNewswire/ — Tuya Smart (NYSE: TUYA; HKEX: 2391), a global AI cloud platform service provider, today announced the launch of Hey Tuya, a next-generation Super AI Life Assistant designed to seamlessly integrate artificial intelligence into daily life. Hey Tuya marks a major milestone in the evolution of AI agents and physical AI. Built on a multi-agent collaborative architecture, it will transform how AI moves beyond screens to deliver proactive, intelligent assistance across home, office, and more scenarios in daily life.


Multi-Device Collaboration: Making AI Ubiquitous

Much like J.A.R.V.I.S., Tony Stark’s iconic AI assistant in the Iron Man movies, Hey Tuya is evolving into more than a virtual assistant answering simple questions. It is designed to become an AI life assistant capable of sensing environments, learning user habits, and coordinating with physical devices. Unlike traditional AI assistants confined to single devices, Hey Tuya is engineered to break beyond the screen, empowering users to summon their AI assistant from anywhere, whether through the Tuya App, smart speakers, control hubs, or even AI toys and wearables. It will facilitate multi-device collaboration and orchestrate smart devices and equipment, delivering a connected and intelligent experience throughout everyday life.


Hey Tuya will feature short-term and long-term memory, designed to learn and adapt to users’ routines, environmental preferences, and habits. Over time, it will evolve beyond reactive commands to anticipate needs and offer proactive recommendations. As it learns your habits, Hey Tuya will possibly suggest turning on the air conditioner 30 minutes before you arrive home, preheating the water heater and opening bedroom curtains ahead of your 7 a.m. wake-up, or dimming lights and activating a humidifier as you wind down for sleep. This continuous learning process will make interactions feel more intuitive, seamless, and efficient.


Full-Scenario Coverage: From Home to Office and Beyond

Hey Tuya’s capabilities are designed to span diverse life scenarios, taking on different roles:

  • Home Security Guardian: Will provide round-the-clock security, with image recognition and retrieval, converting results into easy-to-understand voice or text alerts for clear safety status.
  • Energy-Saving Expert: Will monitor and analyze energy consumption in real time, proactively suggesting strategies like turning off idle devices, shutting off appliances during weekend trips, or adjusting AC temperatures according to weather and seasonal changes, making it easy to save energy with minimal effort.
  • Health Coach: Will focus on physical and mental well-being, support calorie recognition, track sleep and exercise data, and generate personalized health reports.
  • Efficient Work Assistant: Will offer meeting minutes generation, real-time multilingual translation, content summarization, and mind mapping to boost productivity.
  • Personal Life Secretary: Will manage daily tasks such as reminders, holiday alerts, pet and plant care, and family health monitoring for an organized life.


Powered by Tuya’s Proprietary PAE Technology

Hey Tuya’s ubiquitous AI experience is built on Tuya’s proprietary PAE (Physical AI Engine), which deploys the AI-Device Real-Time Network (AD-RTN) edge acceleration network globally. With the AD-RTN as a foundation, Tuya Real-Time Communication (T-RTC) provides a reliable, low-latency, resilient, and global real-time communication system for AI devices.

Tuya has further developed engines for natural language multimodal interaction (Conversational AI Engine), visual understanding (Vision AI Engine), and IoT device communication and control (IoT Intelligence Engine). Leveraging OmniMem long-term memory technology, PAE enables continuous learning across multimodal interactions and device behaviors, allowing the AI to truly understand user preferences and spatial habits.

Through its Adaptive Expert System (AES) and Dynamic Orchestration Agent (DOA), PAE deeply integrates AI cognition and decision-making with real-world smart devices, forming a complete loop from perception to execution—creating intelligent spaces that grow and self-optimize.


Hey Tuya will be available to individual consumers and open to global brands and developers, who will be able to integrate Hey Tuya into their AI hardware or customize it further. Tuya’s open DNA will accelerate the evolution and adoption of Physical AI worldwide, fostering an open, symbiotic, and vibrant AIoT ecosystem.

Currently, developers have created over 12,000 AI Agents on Tuya’s platform, with 155 million daily AI interactions globally across various scenarios. In the future, Hey Tuya will integrate user feedback and best practices to further enhance the experience.

Availability

Hey Tuya is now live with initial capabilities. Users can download the Tuya App from major app stores or visit Tuya.AI to begin the journey with Hey Tuya as it continues to expand its full range of features.

About Tuya Smart

Tuya Smart (NYSE: TUYA; HKEX: 2391) is a global leader in AI cloud platform services, dedicated to applying AI to everyday life. Through its AI Agent development platform and TuyaOpen open-source framework, Tuya integrates multimodal AI capabilities, lowers development barriers, and accelerates AI’s integration with the physical world. Tuya provides innovative Physical AI solutions for smart devices, commercial applications, and industry developers, fostering an open and neutral global ecosystem. As of September 30, 2025, Tuya’s AI developer platform has over 1.622 million registered accounts across more than 200 countries and regions.

For more information: About Tuya | Tuya Smart 

 

From Cloud to Life: Sino Jet Unveils 2025 Unionsky Curated Collection “Business Jet+” Ecosystem

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Advertorial Desk
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Redefining Premium Travel for a New Era

HONG KONG, Dec. 23, 2025 /PRNewswire/ — Sino Jet recently hosted the “Business Jet+ Ecosystem Launch & 2025 Unionsky Curated Collection Awards Ceremony” in Beijing. The event explored two pivotal themes—”From Flight Tool to Lifestyle Curation Platform” and “Chinese Expression of Premium Lifestyle Brands”—gathering representatives from aviation, hotel, dining, and cultural industries to mark a defining moment in China’s business aviation sector.

As industry services grow increasingly standardized and client expectations continue to evolve, Sino Jet has introduced its “Business Jet+” ecosystem strategy, marking a strategic shift from traditional business jet services toward becoming a comprehensive premium lifestyle facilitator. “Our vision”, explained Jenny Lau, Vice Chair of Sino Jet Group, “is to transform business jets into temporal-spatial bridges that connect culture, social connection, and exploration—ensuring every arrival marks the start of an extraordinary experience”.

This innovative approach has led Sino Jet to redefine what “flight efficiency” truly means, elevating it to encompass “experiential efficiency” that enriches every dimension of life and signaling the industry’s transition into a new era defined by ecological value competition.

Building an Ecosystem: Data-Driven Excellence in Lifestyle Standards

The ceremony showcased the release of the industry’s inaugural 2025 Unionsky Curated Collection List—a comprehensive report grounded in authentic consumer behavior analysis. Developed under the guiding principle of “Rooted in Chinese Heritage, Embracing Global Perspectives”, this authoritative list illuminates how China’s high-net-worth population is strategically reshaping its global lifestyle footprint through the “Business Jet+” model, drawing insights from flight trajectory data and over 2,000 premium consumption scenarios spanning 2024-2025.

The list encompasses distinguished categories such as “Top 50 Hotels Preferred by Chinese Business Jet Travelers”, “Top 50 Restaurants”, “Top 50 Golf Courses”, and “Top 10 Cabin Product Brands”. Featured properties include Rosewood Hong Kong, Amanyangyun Shanghai, and Xin Rong Ji Beijing. The ceremony also introduced the concept of “Chinese Business Jet Business Flight Cities”—a recognition that highlights the harmonious blend of heritage and modernity while reflecting diverse value orientations spanning both bustling business hubs and tranquil vacation destinations.

Analysis reveals that consumption patterns among China’s ultra-high-net-worth population demonstrate a distinctive “temporal-spatial value compression” phenomenon: key hubs like Beijing and Shanghai function as strategic resource integration centers, while sought-after destinations such as Cheval Blanc Randheli Maldives attract discerning travelers through their exclusive, hard-to-replicate experiences. This comprehensive list transcends its function as a mere consumption guide; it stands as a testament to Sino Jet’s successful transformation into a true “lifestyle curation platform”, offering its valued clientele an intricate map of global premium living.

Intellectual Resonance: Cross-industry Dialogue on the Present and Future of “Lifestyle Curation”

The ceremony featured two compelling roundtable discussions on “lifestyle” and “cultural expression” respectively.

During the roundtable titled “From Flight Tool to Lifestyle Curation Platform”, the panelist observed a significant evolution in the preferences of China’s high-net-worth population: demands have progressed beyond “standardized luxury” toward a more nuanced pursuit of “personalized abundance”. Within this context, business jets have emerged as essential temporal-spatial carriers, serving as critical nodes that seamlessly link an array of diverse lifestyle scenarios. The discussion highlighted Sino Jet’s innovative “Four Seasons, Six Senses” service system—an approach that weaves Eastern lifestyle aesthetics into the fabric of its offerings, cultivating what can only be described as an “aerial residence” infused with humanistic warmth and distinctive cultural character

The subsequent dialogue on “Chinese Expression of Premium Lifestyle Brands” examined the delicate balance between honoring cultural heritage and embracing contemporary innovation. “Service offerings that lead with Chinese elements”, Jenny remarked during the discussion, “not only demonstrate cultural confidence but also harmoniously integrate international standards, delivering genuine emotional value to our clients”. Jiang Honglin—renowned paper-cut artist, collector, and specially invited artistic ambassador for Sino Jet—contributed the insightful concept of “walking intangible cultural heritage”, which envisions traditional culture not as a museum piece but as a living, breathing element seamlessly integrated into contemporary life.

Sino Jet’s dedication to cultural authenticity manifests through thoughtful innovations such as the incorporation of solar term aesthetics into cabin environments and the launch of the “Masters’ HE” series—a collection inspired by traditional Chinese culture. These initiatives underscore a vital truth: “Chinese expression” represents not mere revival, but rather a confident, contemporary revitalization rooted in deep cultural awareness.

Setting the Standard: A Collaborative Vision for Premium Services

Since its establishment in 2011, Sino Jet has cemented its position as the leading business aviation comprehensive service group throughout the Asia-Pacific region. With operational and maintenance certifications spanning all major aircraft registration jurisdictions globally, the company has constructed an all-encompassing service ecosystem that encompasses aircraft transactions, management, charter services, ground support, business jet terminal operations, and premium travel solutions. Its extensive network reaches over 200 countries and regions worldwide, while its fleet size maintains the top position in Asia-Pacific and manages the largest fleet of Gulfstream G650 globally.

Looking ahead, cross-industry collaboration is poised to evolve toward deeper, more meaningful partnerships characterized by “scenario co-creation and value symbiosis”. All stakeholders are set to leverage Sino Jet’s sophisticated curation platform to establish an ecosystem that is both open and trustworthy, continuously advancing through precise resource alignment and seamless experiential continuity.

According to Li Yuanfeng, President of Sino Jet Group, the 2025 Unionsky Curated Collection List serves a purpose far beyond simple guidance—it represents the premium lifestyle map that Sino Jet, in its capacity as a dedicated “lifestyle curator”, has meticulously crafted for its travelers, charting a clear course for future collaborative creation alongside partner brands across diverse industries.

The 2025 launch of Sino Jet’s “Business Jet+” ecosystem marks not merely a significant milestone in the company’s strategic evolution, but also signifies a broader transformation within China’s premium service sector—a shift from purely “functional delivery” toward profound “meaning creation”. Sino Jet is fundamentally rewriting the very logic of premium travel, transforming the skies into an expansive, boundless canvas that celebrates cultural confidence while drawing together wisdom from every corner of the globe.

For queries please contact:
Sino Jet Marketing Department
Telephone: (+852) 2588 7007 / (+86 10) 8416 2637
Email: marketing@sinojet.org / marketing@sinojet.org.cn
Website: http://www.sinojet.org/

China’s First Domestic Anti-CTLA-4 Monoclonal Antibody, Innovent’s TABOSUN® (Ipilimumab N01 Injection) Received NMPA Approval

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  • TABOSUN® (ipilimumab N01 injection) has been approved in combination with TYVYT® (sintilimab injection) for the neoadjuvant treatment of patients with stage IIB-III resectable microsatellite instability-high or mismatch repair deficient (MSI-H/dMMR) colon cancer.
  • The TABOSUN® and TYVYT® combination therapy significantly improved pathological complete response (pCR) rates and enabled most patients to avoid the burden of postoperative adjuvant chemotherapy.
  • This therapy is the first and only dual-IO regimen approved globally for neoadjuvant treatment of colon cancer[i], filling a critical gap in neoadjuvant treatment of colon cancer and benefiting more patients with MSI-H/dMMR colon cancer.

SAN FRANCISCO and SUZHOU, China, Dec. 25, 2025 /PRNewswire/ — Innovent Biologics, Inc. (“Innovent”) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, announces that the New Drug Application (NDA) for TABOSUN® (ipilimumab N01 injection; R&D Code: IBI310), the first domestic cytotoxic lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibody (mAb), has been approved by China’s National Medical Products Administration (NMPA), in combination with sintilimab as neoadjuvant treatment for stage IIB-III resectable microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colon cancer. TABOSUN® (ipilimumab N01 injection) is the world’s first approved CTLA-4 mAb for neoadjuvant treatment of colon cancer. Short-term neoadjuvant treatment with the ipilimumab N01 and sintilimab combination demonstrated a substantial improvement in pathological complete response, offering the potential to benefit a broader population of patients with MSI-H/dMMR colon cancer.

Resectable MSI-H/dMMR colon cancer urgently requires effective neoadjuvant therapies to improve prognosis

MSI-H/dMMR colon cancer accounts for around 15% of all resectable colon cancer cases[ii]. Due to its unique biological characteristics, this class of tumor shows limited sensitivity to chemotherapy and generally responds poorly[iii]. In recent years, immune checkpoint inhibitors have demonstrated significant efficacy in advanced MSI-H/dMMR colon cancer, but a gap remains in the neoadjuvant setting. For locally advanced MSI-H/dMMR colon cancer, the current standard of care is direct surgery followed by adjuvant chemotherapy. Under this regimen, approximately 10%-30% of patients experience disease recurrence or metastasis after surgery, while chemotherapy-related toxicities may negatively affect quality of life[iv]. Thus in the neoadjuvant setting, there remains an urgent need for more effective therapies to improve outcomes for patients with locally advanced MSI-H/dMMR colon cancer.

The world‘s first dual-IO neoadjuvant therapy: TABOSUN® (ipilimumab N01 injection) combined with TYVYT® (sintilimab injection) markedly enhances pathological complete response rates

Immune checkpoint blockade (ICB) therapy targeting PD-1 and CTLA-4 has transformed cancer treatment. The combination of DABOSUN® (ipilimumab N01 injection) and TYVYT® (sintilimab injection) as neoadjuvant therapy can significantly improve pathological complete response(pCR) rates and allow the majority of patients to avoid adjuvant chemotherapy.

Previously, results from a randomized, controlled Phase 1b trial evaluating ipilimumab N01 plus sintilimab as neoadjuvant treatment for MSI-H/dMMR colon cancer were published in the top-tier journal Cancer Cell[i].

  • As of June 17, 2025, 101 patients were enrolled and randomized to receive ipilimumab N01 plus sintilimab (n=52) or sintilimab alone (n=49).
  • In the per-protocol population, the pCR rate in the ipilimumab N01-plus-sintilimab arm was significantly higher than in the sintilimab-alone arm (80.0% vs 47.7%, p=0.0007).
  • With median follow-up of 21.4 months, no patient experienced disease recurrence.

Approval is based on results from the randomized, controlled, multicenter, pivotal Phase 3 clinical trial (NeoShot, NCT05890742), which evaluated the safety and efficacy of ipilimumab N01 combined with sintilimab as neoadjuvant therapy compared with direct radical surgery for MSI-H/dMMR colon cancer. The primary endpoints are pCR rate and event-free survival (EFS). Interim analysis by the Independent Data Monitoring Committee (IDMC) confirmed that the NeoShot trial met its primary endpoint.

  • As of November 28, 2024, among the first 50 patients in the treatment arm, 41 achieved pathological complete response after neoadjuvant treatment, yielding a pCR rate of 82%.
  • Neoadjuvant treatment with ipilimumab N01 combined with sintilimab did not significantly increase safety risks compared with direct surgery.

Detailed results will be presented at future academic conferences or published in academic journals.

The Principal Investigator of the NeoShot study, Academician of the Chinese Academy of Engineering, Prof. Ruihua Xu from Sun Yat-sen University Cancer Center, stated: “Achieving R0 resection remains challenging for certain patients with locally advanced colon cancer, who also face substantial surgical trauma and poor prognosis. Results from the FOxTROT study indicated that neoadjuvant chemotherapy provides limited benefit in MSI-H/dMMR colon cancer, with a pCR rate of only around 5%[v]. The NeoShot trial is the first randomized, controlled Phase 3 clinical trial to show promising efficacy of dual checkpoint inhibition as neoadjuvant therapy in MSI-H/dMMR colon cancer. Interim analysis suggests that ipilimumab N01 with sintilimab as short-term neoadjuvant treatment can lead to pathological complete response in 82% of treated patients. In addition, NeoShot Ph1b and Ph3 interim results both show the R0 resection under this regimen could reach 100% and spare patients from adjuvant chemotherapy. In NeoShot-1b, the dual-immunotherapy neoadjuvant regimen combining ipilimumab N01 and sintilimab significantly improved the pCR rate, which serves as a surrogate endpoint for long-term prognosis. Based on the existing data, this regimen shows promising potential to reduce recurrence risk and improve long-term survival outcomes. We look forward to observing continued reductions in recurrence with longer-term follow-up. The approval of this dual-immunotherapy regimen is expected to change clinical practice, fill a critical gap in neoadjuvant treatment of colon cancer and benefit more patients with MSI-H/dMMR colon cancer.”

Dr. Hui Zhou, Chief R&D Officer (Oncology) of Innovent, stated: “There remains a substantial unmet clinical need for neoadjuvant therapies for stage IIB-III resectable MSI-H/dMMR colon cancer in China. Interim analysis has shown that the NeoShot trial met its primary endpoint. Through Innovent’s efficient and high-quality clinical development, ipilimumab N01 has become China’s first domestically developed innovative CTLA-4 inhibitor approved by the NMPA, offering a new treatment option for patients in China with stage IIB-III resectable MSI-H/dMMR colon cancer.”

About Ipilimumab N01

Ipilimumab N01 (R&D code: IBI310) is a fully human monoclonal antibody injection independently developed by Innovent. Ipilimumab N01 specifically binds cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), thereby blocking CTLA-4-mediated inhibition of T cell activity, promoting T cell activation and proliferation, improving tumor immune response, and achieving anti-tumor effects. [vi]

The NDA for ipilimumab N01 in combination with sintilimab as neoadjuvant treatment for stage IIB-III resectable microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colon cancer has recently been approved by the NMPA.

About Sintilimab

Sintilimab, marketed as TYVYT® (sintilimab injection) in China, is a PD-1 immunoglobulin G4 monoclonal antibody co-developed by Innovent and Eli Lilly and Company. Sintilimab is a type of immunoglobulin G4 monoclonal antibody, which binds to PD-1 molecules on the surface of T-cells, blocks the PD-1 / PD-Ligand 1 (PD-L1) pathway, and reactivates T-cells to kill cancer cells.[vii]

In China, sintilimab has been approved and included in the updated NRDL for eight indications. The updated NRDL reimbursement scope for TYVYT® (sintilimab injection) includes:

  • For the treatment of relapsed or refractory classic Hodgkin’s lymphoma after two lines or later of systemic chemotherapy;
  • For the first-line treatment of unresectable locally advanced or metastatic non-squamous non-small cell lung cancer lacking EGFR or ALK driver gene mutations;
  • For the treatment of patients with EGFR-mutated locally advanced or metastatic non-squamous non-small cell lung cancer who progressed after EGFR-TKI therapy;
  • For the first-line treatment of unresectable locally advanced or metastatic squamous non-small cell lung cancer;
  • For the first-line treatment of unresectable or metastatic hepatocellular carcinoma with no prior systematic treatment;
  • For the first-line treatment of unresectable locally advanced, recurrent or metastatic esophageal squamous cell carcinoma;
  • For the first-line treatment of unresectable locally advanced, recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma; and
  • In combination with fruquintinib for the treatment of patients with advanced endometrial cancer with pMMR tumors that have failed prior systemic therapy and are not candidates for curative surgery or radiation.

The NDA for sintilimab’s ninth indication, in combination with ipilimumab N01 as neoadjuvant treatment for stage IIB-III resectable MSI-H/dMMR colon cancer is recently approved by the NMPA.

The NDA for sintilimab’s tenth indication, in combination with fruquintinib for the treatment of locally advanced or metastatic renal cell carcinoma who previously failed systematic treatment, has been accepted by the Center for Drug Evaluation (CDE) of NMPA.

In addition, two clinical studies of sintilimab have met their primary endpoints:

  • Phase 2 study of sintilimab monotherapy as second-line treatment of esophageal squamous cell carcinoma; and
  • Phase 3 study of sintilimab monotherapy as second-line treatment for squamous non-small cell lung cancer with disease progression following platinum-based chemotherapy.

About Innovent

Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that target some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has launched 18 products in the market. It has 4 assets in Phase 3 or pivotal clinical trials and 15 more molecules in early clinical stage. Innovent partners with over 30 global healthcare companies, including Lilly, Sanofi, Incyte, LG Chem and MD Anderson Cancer Center.

Guided by the motto, “Start with Integrity, Succeed through Action” Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.

Disclaimer: Innovent does not recommend any off-label usage.

Forward-Looking Statements

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words “anticipate”, “believe”, “estimate”, “expect”, “intend” and similar expressions, as they relate to Innovent, are intended to identify certain of such forward-looking statements. Innovent does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of Innovent with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond Innovent’s control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, Innovent’s competitive environment and political, economic, legal and social conditions.

Reference:

i. Wang F,et al. Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study. Cancer Cell. 2025 Oct 2:S1535-6108(25)00396-4. doi: 10.1016/j.ccell.2025.09.004.

ii. Gutierrez C, et al. The Prevalence and Prognosis of Microsatellite Instability-High/Mismatch Repair-Deficient Colorectal Adenocarcinomas in the United States. JCO Precis Oncol. 2023;7:e2200179. doi:10.1200/PO.22.00179

iii. Sargent DJ, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol. 2010;28(20):3219-3226. doi:10.1200/JCO.2009.27.1825

iv. André T, et al. Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study. J Clin Oncol. 2015;33(35):4176-4187. doi:10.1200/JCO.2015.63.4238

v. Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. doi:10.1200/JCO.22.00046.

vi. Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. doi:10.1634/theoncologist.13-S4-2

vii. Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. doi:10.1080/19420862.2019.1654303

 

SCG Advances Regional Optimization Strategy for Sustainable Growth

By
Advertorial Desk
-

Positioning Vietnam as Production-Export Hub to Global Markets, with SCGD Leading Decorative Surface Materials and Ceramic Tiles Market Ready to Drive Cement Business Expansion of Low-Carbon Products to Global Markets


HCMC, VIETNAM – Media OutReach Newswire – 25 December 2025 – SCG continues its Regional Optimization strategy, positioning Vietnam as a Strategic Hub in the ASEAN region for manufacturing and exports to global markets. SCG Decor (SCGD) supports PRIME GROUP in expanding production capacity for high-quality tiles to meet growing demand. The cement and building materials business in Vietnam is accelerating development of low-carbon cement for both domestic sales and global exports under the Green Building policy
to create sustainable growth while enhancing quality of life.

SCG's Business in Vietnam page-0001

Mr. Kulachet Dharachandra, Country Director – Vietnam, SCG, stated: “Vietnam is a strategically important country for SCG, with total investments exceeding 7 billion US dollars across 28 companies, representing 28% of SCG’s total assets. This covers chemicals, cement, building materials, packaging, and logistics businesses to serve both domestic and export market demands, enhancing competitive capabilities and building comprehensive production and supply chain potential.

Under the Regional Optimization strategy, SCG combines the strengths of Thailand and Vietnam in digital technology, artificial intelligence and automation, safety standards, and plant management, as well as social, environmental, and governance practices following ESG principles. Vietnam is a high-growth potential market due to its economy, government infrastructure policies, and increasing Green Building trends. It also has consumers with purchasing power for high-quality products and a large consumer base of over 100 million people, plus export potential with efficient production costs, which strengthens sustainable business growth and elevates quality of life in the region.”

SCGD supports PRIME GROUP, Vietnam’s Number One Market Leader of Decor Surface

PRIME GROUP, the flagship business in which SCG acquired shares in 2012, is the market leader of decorative surface materials in Vietnam and will be a key force strengthening SCGD toward its goal of becoming ASEAN leader.

Mr. Numpol Malichai, The Chief Executive Officer and President of SCG Decor Public Company Limited, stated: “Vietnam’s economy is growing, the middle class is expanding, and the real estate market is recovering in mid-range to premium residential projects that favor Glazed Porcelain (GP) tiles, leading to continuously increasing demand for these products.

PRIME has sales revenue of approximately 5,500 million baht with total production capacity of around 80 million square meters. The company plans to invest in expanding GP tile production capacity from 19 million square meters in 2025 to 25.6 million square meters in 2026, targeting expansion to 45 million square meters by 2030 to align with increasing demand. PRIME can also manage and control production costs of GP tiles to be able to competitive with the products from world-class competitors. This cost advantage supports PRIME to become the strategic production and export base of SCGD, strengthening the Regional Optimization strategy for sustainable growth.

In response to market change and maintain competitive level, PRIME invested in Biomass Gasifier systems at the Pho Yen plant to replace fossil fuel with biomass, thereby reducing energy costs and greenhouse gases, supporting Vietnam to become the strategic export hub to ASEAN and other countries. Furthermore, PRIME’s products meet customers’ needs of all market segments with product offering that covers innovative design and health and safety functions that are well-recognized throughout the Asian region. This supports business growth along with environmental care enhancement. Additionally, SCGD grows bathroom business and strengthens COTTO brand in the ASEAN market with over 44 distributors appointed in Vietnam, as well as growing Complementary products such as adhesive and grout, and others.”

SCG Low-Carbon Cement Supports Vietnam’s Infrastructure and Green Cities, Advancing Its Role as a Global Export Hub

SCG Cement and Building Materials has operated in Vietnam for more than 20 years, with 11 companies across the cement, roofing, and building materials businesses. With production bases located in the central and southern regions, the company supports domestic market growth while also serving as a strategic manufacturing hub for exports to global markets.

Mr. Wichet Chuchaeu, Country Director – Vietnam, SCG Cement and Building Materials Business, stated: “Vietnam’s economy continued to expand in 2025, driven by growth in the industrial and construction sectors. Accelerated government infrastructure investment has supported a steady recovery in demand for building materials and cement—especially low-carbon cement, whose growth aligns with national policies such as the 2050 Net Zero Emission commitment and the Green City policy, which targets that by 2050 at least 50% of new urban areas and 10% of all cities nationwide must meet government-defined green city criteria.”

The cement business has an annual production capacity of 3 million tons of clinker and 4 million tons of cement. Vietnam is the best-managed production-cost base among SCG’s regional cement operations, positioning the country not only as a strong domestic supply base but also as a key hub for exports. SCG currently exports both low-carbon cement and clinker to America, Europe, Africa, Oceania, and Asia.

SCG Cement continues to enhance environmental performance through the use of alternative and recycled materials, reduced coal consumption via alternative fuels such as biomass and refuse-derived fuel (RDF), and the implementation of Waste Heat Recovery (WHR) systems that significantly reduce natural resources, lower energy consumption and reduce CO2 emission.

These initiatives have earned SCG recognition through international environmental standards, including Singapore Green Building Product certification and International Environmental Product Declaration (EPD) System certification—affirming sustainability from production through to finished products.

“Our investment strategy and production cost optimization under the Regional Optimization concept have strengthened SCG’s competitiveness. Vietnam is now positioned as a central hub for manufacturing and exporting quality products to global markets. This supports growing demand for high-quality surface materials and environmentally friendly building materials, contributing to green city development and sustainably enhancing the quality of life for people in Vietnam and the region.”, Mr. Kulachet concluded.

Hashtag: #SCGCement

The issuer is solely responsible for the content of this announcement.

Thailand welcomes 2026 with countdown celebrations anchored by Phayao and Su-ngai Kolok

By
Advertorial Desk
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Tourism Authority of Thailand spotlights two flagship regional events alongside celebrations across Bangkok and key provincial destinations to mark the New Year

BANGKOK, Dec. 25, 2025 /PRNewswire/ — Thailand is welcoming the arrival of 2026 with a nationwide programme of countdown celebrations, anchored by two flagship events organised by the Tourism Authority of Thailand (TAT) in Phayao and Su-ngai Kolok, alongside a series of TAT-supported festivities across Bangkok and major destinations nationwide.

Thailand is set to welcome 2026 with nationwide countdown celebrations anchored by flagship events in Phayao and Su-ngai Kolok, alongside TAT-supported festivities across Bangkok and key destinations nationwide.
Thailand is set to welcome 2026 with nationwide countdown celebrations anchored by flagship events in Phayao and Su-ngai Kolok, alongside TAT-supported festivities across Bangkok and key destinations nationwide.

Ms. Thapanee Kiatphaibool, TAT Governor, said, “The two flagship events organised by TAT in Phayao and Su-ngai Kolok represent a strategic focus on showcasing regional identity through meaningful, high-quality celebrations. These events are complemented by strong public–private collaboration in Bangkok and other provinces, creating a nationwide countdown atmosphere that invites visitors to experience Thailand’s diversity at the turn of the year. The combined programme reinforces confidence in Thailand as a welcoming, creative and culturally rich destination as the country enters 2026.”

In northern Thailand, Amazing Thailand Phayao Countdown Flora Fest 2026 will take place from 28–31 December 2025 at Pho Khun Ngam Mueang Monument Plaza and around Kwan Phayao. Paying tribute to Her Majesty Queen Sirikit, The Queen Mother, the event is designed to introduce new experiential formats while elevating Phayao as an emerging global destination recognised for its cultural heritage, natural beauty and warm local hospitality. The four-day programme features large-scale lighting and installation displays and floral art exhibition zones, complemented by drone performances from 29–31 December and a grand New Year’s Eve fireworks display on 31 December. The celebrations will culminate in a high-profile countdown evening marked by ceremonial proceedings and VIP attendance, reinforcing the event’s stature as one of Thailand’s most visually spectacular year-end celebrations.

In Thailand’s deep South, Amazing Thailand Su-ngai Kolok Countdown 2026 will be staged from 28–31 December 2025 at Sirindhorn Public Park, Su-ngai Kolok, Narathiwat. The event highlights the cultural richness and contemporary creative energy of the border region through decorative lighting, live concerts by nationally recognised artists and performances rooted in local traditions. Each evening presents a curated mix of cultural showcases and contemporary music, building towards the New Year’s Eve countdown and fireworks display shortly before midnight. The official countdown ceremony, attended by senior representatives from Thailand and neighbouring Malaysia, underscores Su-ngai Kolok’s role as a cross-border cultural and tourism gateway.

Beyond these two core events, TAT is also supporting a wide range of Thailand countdown celebrations 2026 that reinforce the country’s position as one of Asia’s leading festive destinations.

In Bangkok, the Amazing Thailand Countdown 2026 at ICONSIAM from 27–31 December features four-dimensional sky performances combining environmentally friendly fireworks, drones, and pyrotechnics over the Chao Phraya River, alongside appearances by global and Thai iconic artists, including a special performance by Mark Tuan. One Bangkok Countdown Celebration 2026 on 31 December presents a new urban landmark with live performances by internationally renowned Korean artists, immersive light-and-sound shows and a central city countdown experience. CentralwOrld Bangkok Countdown 2026 on 31 December continues its role as the “Times Square of Asia“ with headline concerts, special performances and a landmark fireworks display. NEON Countdown 2026 at Rajamangala National Stadium on 30–31 December delivers a large-scale EDM experience featuring top-ranked global DJs, transforming the stadium into a high-energy New Year party destination. Extravaganza Sukhumvit Countdown 2026 on 31 December creates a first-of-its-kind urban spectacle, with coordinated fireworks launched across more than five kilometres of Sukhumvit Road around the EM District, uniting retail, hospitality and entertainment districts into a single countdown corridor.

Provincial destinations are also marking the New Year with distinctive local celebrations that strengthen regional tourism appeal. Hat Yai New Year 2026, held at Thumnoonvithi Road (Odeon Intersection) in Hat Yai, Songkhla, on 30–31 December, combines live music, cultural performances and a city-centre countdown celebrating the revival of southern Thailand’s key tourism hub. Hua Hin Countdown 2026, taking place at InterContinental Hua Hin Resort on 31 December, offers a beachfront New Year experience with live DJs, fireworks and family-friendly activities, positioning Hua Hin as a relaxed yet festive coastal destination. Udon Countdown 2026, staged at UD TOWN in Udon Thani on 31 December, features live entertainment, decorative lighting, food zones and a midnight fireworks countdown, supporting year-end travel and local economic activity in the Northeast.

All events are scheduled to take place between 27 and 31 December 2025, with New Year’s Eve countdowns and fireworks marking the transition into 2026 across the country. A full listing of countdown events nationwide is available at the Thailand events calendar for Countdown 2026.

As part of the nationwide countdown programme, comprehensive safety and security measures have been put in place to ensure a safe, orderly and enjoyable experience for visitors. The Royal Thai Police are deploying personnel, vehicles and modern security technologies to support event operations across the country, while the Tourist Police are fully prepared to assist travellers and manage crowd movement at key celebration sites.

Finding Her Flag: Lao-American Golfer Malisone Chanthapanya’s First Swing for Laos

By
Phontham Visapra
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Finding Her Flag: Lao-American Golfer Mali Chathapanya’s First Swing for Laos
Malisone swinging her golf club during her training in Laos (photo credit: Thongsavnh Souvannasane)

Malisone Chanthapanya, a 22-year-old Lao-American golfer, was selected to represent Laos professionally at the SEA Games this year, marking both her first appearance at the regional multi-sport event and her first visit to the country.

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