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Court Sides with Cardiovalve in Edwards patent spat

HANGZHOU, China, Aug. 5, 2025 /PRNewswire/ — Venus Medtech (Hangzhou) Inc. (“Venus Medtech”, Stock Code: 02500.HK) recently announced a decisive legal victory for its wholly-owned subsidiary Cardiovalve Ltd. (“Cardiovalve”) against Edwards Lifesciences Corporation and Edwards Lifesciences LLC. (collectively “Edwards”). The United States Court of Appeals for the Federal Circuit (“CAFC”) has formally issued its mandate in Case 23-1515, affirming the Patent Trial and Appeal Board’s (“PTAB”) December 2022 ruling that upheld the validity of Cardiovalve’s patent. This follows Edwards’ failure to file a petition for rehearing within the statutory deadline by July 16, 2025.

This outcome conclusively defends the validity of Cardiovalve’s critical patent portfolio, strengthens Venus Medtech’s global IP protections, and significantly advances its competitive position in structural heart disease—particularly its integrated “Quad-Valve” strategic platform.

Case Background

The dispute centered on Edwards’ challenge to the validity of Cardiovalve’s U.S. Patent No. 10,702,385 (“‘385 Patent”) covering an innovative transcatheter heart valve clamping and support structure for minimally invasive mitral and tricuspid valve therapies.

On June 2, 2021, Edwards petitioned for inter partes review of claims 1-10 of that patent.

PTAB issued Final Written Decision allowing Cardiovalve’s motion to amend claims after Edwards failed to prove unpatentability by preponderant evidence on December 6, 2022.

On June 9, 2025, CAFC affirmed PTAB’s ruling, validating Cardiovalve’s patent claims.

About Cardiovalve

Venus Medtech completed the acquisition of Cardiovalve in January 2022, that marked a strategic milestone in building a comprehensive product portfolio and securing Cardiovalve’s foundational technologies.

Cardiovalve, the next-generation transcatheter valve replacement system, is designed for treating regurgitation in both mitral and tricuspid valves, and features transformative technologies:

  • Dual frame self-expanding nitinol stent reduces paravalvular leakage
  • Low-profile stent design minimizes LVOT obstruction risk
  • Transfemoral-transseptal access provides a less invasive alternative to the transapical approach
  • Large annular sizing capacity (up to 55mm) accommodates approximately 95% of patient anatomies

The streamlined three-step implantation (Position-Anchor-Release) demonstrates exceptional reproducibility.

Mr. Lim Hou-Sen, CEO of Venus Medtech stated:

“This landmark victory validates Cardiovalve’s original innovations and demonstrates the integrity of global IP systems. We remain committed to advancing structural heart therapies through clinically driven innovation.”

Mr. Amir Gross, CEO of Cardiovalve emphasized:

“Our ‘Innovation Never Stops’ philosophy conquered technical barriers in mitral/tricuspid interventions. This four-year legal affirmation accelerates our global clinical strategy to deliver superior solutions for 40+ million regurgitation patients worldwide.”

First Phosphate Announces Intention to Complete Non-Brokered Private Placement to Accommodate Demand from Existing Investor


Saguenay, Quebec – Newsfile Corp. – August 5, 2025 – First Phosphate Corp. (CSE: PHOS) (OTCQB: FRSPF) (FSE: KD0) (“First Phosphate” or the “Company”) is pleased to announce a non-brokered private placement for gross proceeds of a minimum of $1 million to accommodate demand from an existing investor (the “Offering“).

The Offering is anticipated to consist of any combination of:

  1. Flow-through shares of the Company (“Flow-Through Shares“) at a price of $0.50 per share (“Flow-Through Offering“); and
  2. Hard dollar units of the Company (“Hard Dollar Unit“) at a price of $0.50 per Hard Dollar Unit (the “Hard Dollar Unit Offering“), with each Hard Dollar Unit comprised of: (i) one common share in the capital of the Company (“Common Share“), and (ii) one half of one Common Share purchase warrant (“Warrant“) with each whole Warrant exercisable for one Common Share at a price of $0.50 per Common Share until December 31, 2025, subject to an Accelerated Expiry Date (as defined below).

The gross proceeds from the Flow-Through Offering will be used to incur “Canadian exploration expenses” that are “flow-through mining expenditures” (as such terms are defined in the Income Tax Act (Canada)) related to the Company’s projects in Québec. The net proceeds received from the Hard Dollar Unit Offering will be used for exploration and development activities, working capital and for general corporate purposes. The Offering is expected to close on or about August 22, 2025, or such other date or dates as may be determined by the Company. All securities issued under the Offering will be subject to a four-month and one day statutory hold period in accordance with applicable securities laws.

In connection with the Offering, eligible finders will be paid: (i) a fee consisting of up to 8% of the gross proceeds raised from subscribers introduced by them, and (ii) such number of compensation warrants (“Compensation Warrants“) as is equivalent of up to 8% of the number of Hard Dollar Units or Flow-Through Shares issued to subscribers introduced by them. Each Compensation Warrant shall entitle the holder thereof to acquire one Common Share at a price of $0.50 per share until December 31, 2025, provided that if the volume weighted average trading price of the Common Shares on the Canadian Securities Exchange for any 5 consecutive trading days equals or exceeds $0.80, the Company may, upon issuing a press release, accelerate the expiry date of the Compensation Warrants to the date that is 30 days following the date of such press release (“Accelerated Expiry Date“). The Company reserves the right to pay cash finders’ fees on the Flow-Through Offering in Common Shares rather than cash issued at the Flow-Through Offering issue price.

This news release does not constitute an offer to sell or a solicitation of an offer to sell any of securities in the United States. The securities have not been and will not be registered under the United States Securities Act of 1933, as amended (the “U.S. Securities Act“) or any state securities laws and may not be offered or sold within the United States or to U.S. Persons unless registered under the U.S. Securities Act and applicable state securities laws or an exemption from such registration is available. Completion of the Offering is subject to certain conditions including, but not limited to, the receipt of all necessary approvals. There can be no assurance that the Offering will be completed, whether in whole or in part.

About First Phosphate Corp.

First Phosphate (CSE: PHOS) (OTCQB: FRSPF) (FSE: KD0) is a mineral development company dedicated to producing high-purity phosphate for the LFP battery industry. The Company is committed to sustainable extraction and purification with a low anticipated carbon footprint. Its vertically integrated model connects phosphate mining directly into the supply chains of North American battery producers. First Phosphate’s flagship project, the Bégin-Lamarche Property in Saguenay-Lac-Saint-Jean, Quebec, contains rare igneous anorthosite rock that yields high-purity phosphate with minimal impurities.

Media & Investor Contact:
Bennett Kurtz
Chief Financial Officer
bennett@firstphosphate.com
Tel: +1 (416) 200-0657

Investor Relations: investor@firstphosphate.com
Media Relations: media@firstphosphate.com
Website: www.FirstPhosphate.com

Follow First Phosphate:
X: https://x.com/FirstPhosphate
LinkedIn: https://www.linkedin.com/company/first-phosphate

Forward-Looking Information and Cautionary Statements
This news release contains certain statements and information that may be considered “forward-looking statements” and “forward looking information” within the meaning of applicable securities laws. In some cases, but not necessarily in all cases, forward-looking statements and forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “targets”, “expects” or “does not expect”, “is expected”, “an opportunity exists”, “is positioned”, “estimates”, “intends”, “assumes”, “anticipates” or “does not anticipate” or “believes”, or variations of such words and phrases or statements that certain actions, events or results “may”, “could”, “would”, “might”, “will” or “will be taken”, “occur” or “be achieved” and other similar expressions. In addition, statements in this news release that are not historical facts are forward looking statements, including, among other things: the Company’s planned exploration and production activities; the properties and composition of any extracted phosphate; the Company’s plans for vertical integration into North American supply chains; the minimum gross proceeds of $1,000,000; the use of proceeds from the Offering; the terms of the Offering, including, the issuance of any securities, the closing date, and the receipt of all necessary approvals.

These statements and other forward-looking information are based on assumptions and estimates that the Company believes are appropriate and reasonable in the circumstances, which may prove to be incorrect, include, but are not limited to, the various assumptions set forth herein and in the Company’s public disclosure record including the short form base prospectus dated June 5, 2024, as well as: the receipt of all necessary approvals and the Company’s ability to raise the minimum gross proceeds of $1,000,000.

There can be no assurance that such statements will prove to be accurate, and actual results and future events could differ materially from those anticipated in such statements. There can be no assurance that any opportunity will be successful, commercially viable, completed on time or on budget, or will generate any meaningful revenues, savings or earnings, as the case may be, for the Company. In addition, the Company will incur costs in pursuing any particular opportunity, which may be significant. These factors and assumptions are not intended to represent a complete list of the factors and assumptions that could affect the Company and, though they should be considered carefully, should be considered in conjunction with the risk factors described in the Company’s other documents filed with the Canadian and United States securities authorities, including without limitation the “Risk Factors” section of the Company’s Management Discussion and Analysis dated July 25, 2025 and Annual Report on 20-F dated July 8, 2024, which are available on SEDAR at www.sedarplus.ca. Although the Company has attempted to identify factors that would cause actual actions, events or results to differ materially from those disclosed in the forward-looking information or information, there may be other factors that cause actions, events or results not to be as anticipated, estimated or intended. The Company does not undertake to update any forward-looking information, except in accordance with applicable securities laws.

THIS NEWS RELEASE IS INTENDED FOR DISTRIBUTION IN CANADA ONLY AND IS NOT INTENDED FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR DISSEMINATION IN THE UNITED STATES.

The issuer is solely responsible for the content of this announcement.

About First Phosphate Corp.

Aurzen Redefines Portable Entertainment with BOOM air, a Searchlight-Style Projector Featuring Powerful Built-in Dolby Audio

The ultra-portable projector boasts a 110° integrated gimbal, Google TV, and real-time focus for effortless big-screen experiences on any surface.

IRVINE, Calif., Aug. 5, 2025 /PRNewswire/ — Aurzen, an innovator in immersive home entertainment, today redefines the portable projector category with the launch of BOOM air. This striking searchlight-style projector packs a powerful audio system and smart TV functionality into a compact, go-anywhere design, eliminating the need for extra speakers or streaming devices.

The BOOM air is engineered for convenience and performance. Its unique form factor is not just for looks—it houses a robust 10W speaker tuned with Dolby Audio, delivering cinematic sound that fills the room without an external soundbar. This integrated design, combined with its ultra-portable size and power bank compatibility, makes it the perfect all-in-one entertainment hub for movie nights, backyard gatherings, or professional presentations.

An All-in-One Design Philosophy

The design of the BOOM air directly addresses a core challenge in the portable projector market: the trade-off between portability and audio quality. By engineering a powerful10W Dolby Audio system directly into the projector’s unique gimbal-style body, Aurzen has created a truly all-in-one entertainment device. This integration ensures that the immersive, room-filling sound matches the quality of the Full HD projection, delivering a complete cinematic experience without the need for additional accessories. The goal is to provide a grab-and-go cinema experience that is intuitive, versatile, and powerful.

Key Features of the Aurzen BOOM air:

  • Point-and-Play Simplicity (110° Gimbal Stand): The integrated 110° gimbal stand allows you to aim the projection anywhere—from the wall to the ceiling—without needing a separate tripod or stack of books. Setup is instant and versatile.
  • Room-Filling Dolby Audio (10W Speaker): Powerful, built-in 10W speaker with Dolby Audio creates a rich, immersive soundscape, eliminating the cost and hassle of external speakers.
  • Smart TV Built-In (Google TV): Enjoy endless entertainment with Google TV, which provides direct access to thousands of apps like Netflix, YouTube, and Disney+, plus seamless voice control via Google Assistant.
  • Crystal-Clear Real-time Focus (ToF): Sophisticated Time-of-Flight (ToF) sensors instantly analyze the projection surface to deliver a perfectly sharp image in seconds, with no manual adjustments needed.
  • Ultimate Portability (Power Bank Ready): A highly efficient design allows BOOM air to be powered by standard USB-C power banks, offering true freedom to watch anywhere, even when you’re off the grid.

Technical Specifications:

  • Brightness: 300 ANSI Lumens
  • Resolution: Native 1080p (Full HD)
  • Screen Size: 40″ to 250″
  • Audio: 10W Speaker with Dolby Audio
  • Smart OS: Google TV
  • Image Correction: Time-of-Flight (ToF) Real-time Focus, Auto Keystone (Vertical & Horizontal)
  • Connectivity: USB-C, HDMI, Wi-Fi, Bluetooth

Pricing and Availability

The Aurzen BOOM air launched on August 4 and is now available on Aurzen.com and Amazon at a suggested retail price of $299.99.

About Aurzen

Aurzen is a global brand dedicated to creating innovative and accessible projection technology. By combining user-centric design, cutting-edge software, and premium audio-visual components, Aurzen aims to transform any space into an immersive entertainment experience. The company’s products are designed for modern lifestyles, offering simplicity, portability, and performance.

For more information, high-resolution images, or to request a review unit, please contact: 
Aurzen
media@aurzen.com
https://aurzen.com/

Envision Energy Achieves Breakthrough in Two-Blade Wind Turbine Technology with Over 500 Days of Stable Operation

SHANGHAI, Aug. 5, 2025 /PRNewswire/ — Envision Energy, a global leader in green technology, has announced a significant breakthrough in wind power innovation: its next-generation two-blade onshore smart turbine prototype has achieved over 500 days of stable operation, with a remarkable availability rate of 99.3%, MTBT of 2,444 hours, and equivalent full-load hours reaching 3,048 hours per year. Field performance confirms that the two-blade turbine is on par with traditional three-blade machines operating at the same site.

Envision Energy’s Two-Blade Wind Turbine Achieves 500 Days of Stable Operation
Envision Energy’s Two-Blade Wind Turbine Achieves 500 Days of Stable Operation

This turbine is built on Envision’s Model X onshore platform, featuring a modular design and high-speed DFIG (Doubly-Fed Induction Generator) technology with enhanced stability. Designed for high performance, lightweight construction, and system-level efficiency, it offers a competitive integrated energy solution for diversified green power applications.

“By overcoming key technical challenges such as excessive system vibration and load imbalance – barriers that have long held back two-blade designs, Envision has once again redefined wind power innovation by becoming the first in the industry to demonstrate long-term operational verification of a next-generation two-blade turbine.” said Mr. Lou Yimin, Senior Vice President and Chief Product Officer at Envision Energy.

Envision’s journey with two-blade turbine technology began more than a decade ago. In 2012, the company’s Global Innovation Center (GIC) in Denmark successfully developed the “Game Changer” – a 3.6 MW offshore two-blade turbine – becoming one of the first global innovators to pioneer this unconventional design in the heartland of the wind industry. Since the prototype was installed in 2013, Envision has accumulated significant product development and operational know-how, laying the foundation for its new-generation two-blade turbines.

To bring new technology from concept to commercialization, extensive validation is critical. Envision’s two-blade turbine underwent months of rigorous testing and nearly two years of real-world field operation at its smart wind power verification center, backed by a multi-level, full-process, all-condition validation system. Notably, using one of the  industry’s first multi-degree-of-freedom full-system loading test rigs, Envision defined dozens of unique two-blade operating conditions, focusing on critical performance metrics. All parameters were systematically planned, tested, and validated to ensure technological maturity and readiness for commercial deployment.

Envision’s new-generation two-blade turbine offers a fresh alternative to conventional three-blade models, particularly in scenarios where cost efficiency, transportability, and modular deployment are paramount. This breakthrough reaffirms Envision’s leadership in global wind innovation and its commitment to accelerating the transition to net zero through next-generation clean energy technologies.

 

Multiplier Launches ‘Beyond Borders’ Series to Explore the Realities of Global Employment

The new video series features conversations with global experts and future-of-work influencers on the challenges and opportunities of hiring, scaling, and managing teams across borders.

NEW YORK, Aug. 5, 2025 /PRNewswire/ — With about 74% of employers worldwide struggling to find skilled talent, spanning industries from healthcare to engineering, global hiring has become a necessity. In IT alone, over 90% of organizations are expected to face skills gaps by 2026. To help companies navigate this, Multiplier, the leading global employment platform, has launched Beyond Borders: New York, a new in-person video series featuring candid conversations between Multiplier leaders and influential voices in HR, compliance, payroll, and the future of work.

As companies scale internationally, HR and business leaders must adapt, from compliance to people strategy. Beyond Borders goes beyond today’s challenges to explore what’s next. Across eight episodes, the series explores every angle of global employment through conversations with the people shaping it, from founders and function heads to HR leaders and analysts. Together, they examine pressing issues including the global talent shortage, reimagining HR in the age of AI, and pay equity for women in distributed teams.

Our goal was to spark grounded, unscripted dialogue between people who approach the same challenges from different angles and rarely get the chance to meet on the same stage,” said Sagar Khatri, CEO and co-founder of Multiplier. “We paired Multiplier executives with voices who approach global employment from the outside in — people who observe, analyze, and shape the trends transforming work.”

Each episode sits at the intersection of insight and experience, pairing tech leaders with HR strategists, product operators with analysts, and company insiders with external observers.

Featured conversations include:

  • Hebba Youssef (Chief People Officer, Workweek) and Sagar Khatri (CEO, Multiplier) on global HR burnout
  • Aman Kidwai (Editor, Newsweek), Rani Molla (Senior Tech Correspondent, Sherwood News), and Amritpal Singh (Co-founder & President of Field Operations, Multiplier) on global hiring as a response to the talent crisis
  • Erin Grau (COO, Charter) and Jen Briede (VP of Client Solutions, Multiplier) on women in the global workplace
  • Jeanne Meister (Future Workplace) and Vamsi Krishna (Co-founder & MD Global HR Compliance & Advisory, Multiplier) on the intersection of AI and HR
  • Pete Tiliakos (Principal Analyst, Strategic Advisor) and Michael Nierstedt (Product Director, Multiplier) on payroll for a borderless workforce
  • Kathryn Minshew (Founder, The Muse) and Sagar Khatri on adopting a global mindset
  • Sarah Reynolds (Analyst, Lighthouse) and Monish Munshi (CMO, Multiplier) on building global brands
  • Vinnie DiAngelo (VP of People Operations & Organizational Effectiveness, TriNet) and Matthew Carr (CRO, Multiplier) on leading high-performing global-first teams

The series is aimed at CHROs, people leaders, founders, and senior decision-makers tasked with scaling internationally and adapting people strategy to a global reality. While Beyond Borders debuts in New York, Multiplier plans to expand the series to other key markets, spotlighting local and global voices tackling the future of work from every angle.

The Beyond Borders New York series is now rolling out on Multiplier’s website, with one episode releasing each week over the next eight weeks. The first episode, on HR burnout, is now live.

END

About Multiplier

Multiplier is a global employment platform for HR leaders and professionals who need an easy, fast, and cost-effective way to onboard, hire, manage and pay the best global talent across 150+ countries. Through its best-in-class EOR, COR, Global Payroll, and compliance technology, plus person-to-person support and hyper-local employee benefits, Multiplier empowers its customers to hire the best global talent and build a world of limitless opportunity.

 

Liaoning Rural Tourism: A Year-Round Vista among Mountains and Seas

SHENYANG, China, Aug. 5, 2025 /PRNewswire/ — A news report from CRI:

 

 “Peach blossoms blush like dawn clouds, pear flowers gleam as winter’s snow, maple forests blaze in autumn glory, and snowfields stretch beyond the horizon.” Liaoning captivates visitors with an ever-unfolding rural panorama that shifts with the seasons, establishing itself a destination for all-year travel. The province’s cultural and tourism sector maintains its remarkable momentum. From January to June, visitor arrivals surged by 17.81%, with inbound tourists jumping 44.72% year-on-year, nearly half of whom extended their stays to four days or longer.

A Riot of Blooms and Wings in Spring

In late March, Hekou Village in Kuandian County, Dandong dazzled as miles of peach blossoms along the Yalu River burst into pink glory. The “Pear Blossom Avenue” in Beizhen, Jinzhou saw daily foot traffic peak at 50,000. At the Wolong Lake in Kangping and the tidal flats in Yingkou—key stopovers on the East Asian-Australasian Flyway—over 120,000 rare birds, including red-crowned cranes and swans, are spotted in spring.

An Adventure through Waves and Tides in Summer

This July in Changhai County, Dalian, fisherman Wang Zhongmin’s eight seaside rooms were fully reserved even before May Day holiday, and the demand never waned. The Daludao Island in Dandong and the Xingcheng Beach in Huludao rolled out new offerings like sailing and beach glamping.

A Feast of Colors and Harvest in Autumn

Launching in September, a new “Scarlet Leaves & Paddy Crabs” itinerary will link Benxi’s Guanmen Mountain, Panjin’s Red Beach, and its Rice Park. By day, tourists photograph crimson canopies; by night, they steam freshwater crabs.

A Delight of Snow and Ice in Winter

Gongchangling Ski Resort in Liaoyang will debut nighttime slope lighting this winter, with its hot-spring hotels projected at 80% occupancy. Meanwhile, Northeast-style winter markets in Shenyang and Fushun will buzz alongside lunar new year festivities, featuring Benxi’s Shehuo fire dances and Jinzhou’s shadow puppetry.

An official from Liaoning’s Department of Culture and Tourism announced plans to strategically leverage its “coastal landscapes, borderland charm, Liao cultural heritage, and red tourism” assets, curating more national “Four Seasons in the Countryside” premium routes. By 2025, the province aims to hit 100 million rural tourist arrivals annually.

Liaoning Rural Tourism: A Year-Round Vista among Mountains and Seas

SHENYANG, China, Aug. 5, 2025 /PRNewswire/ — A news report from CRI:

 

“Peach blossoms blush like dawn clouds, pear flowers gleam as winter’s snow, maple forests blaze in autumn glory, and snowfields stretch beyond the horizon.” Liaoning captivates visitors with an ever-unfolding rural panorama that shifts with the seasons, establishing itself a destination for all-year travel. The province’s cultural and tourism sector maintains its remarkable momentum. From January to June, visitor arrivals surged by 17.81%, with inbound tourists jumping 44.72% year-on-year, nearly half of whom extended their stays to four days or longer.

A Riot of Blooms and Wings in Spring

In late March, Hekou Village in Kuandian County, Dandong dazzled as miles of peach blossoms along the Yalu River burst into pink glory. The “Pear Blossom Avenue” in Beizhen, Jinzhou saw daily foot traffic peak at 50,000. At the Wolong Lake in Kangping and the tidal flats in Yingkou—key stopovers on the East Asian-Australasian Flyway—over 120,000 rare birds, including red-crowned cranes and swans, are spotted in spring.

An Adventure through Waves and Tides in Summer

This July in Changhai County, Dalian, fisherman Wang Zhongmin’s eight seaside rooms were fully reserved even before May Day holiday, and the demand never waned. The Daludao Island in Dandong and the Xingcheng Beach in Huludao rolled out new offerings like sailing and beach glamping.

A Feast of Colors and Harvest in Autumn

Launching in September, a new “Scarlet Leaves & Paddy Crabs” itinerary will link Benxi’s Guanmen Mountain, Panjin’s Red Beach, and its Rice Park. By day, tourists photograph crimson canopies; by night, they steam freshwater crabs.

A Delight of Snow and Ice in Winter

Gongchangling Ski Resort in Liaoyang will debut nighttime slope lighting this winter, with its hot-spring hotels projected at 80% occupancy. Meanwhile, Northeast-style winter markets in Shenyang and Fushun will buzz alongside lunar new year festivities, featuring Benxi’s Shehuo fire dances and Jinzhou’s shadow puppetry.

An official from Liaoning’s Department of Culture and Tourism announced plans to strategically leverage its “coastal landscapes, borderland charm, Liao cultural heritage, and red tourism” assets, curating more national “Four Seasons in the Countryside” premium routes. By 2025, the province aims to hit 100 million rural tourist arrivals annually.

 

Ascletis Completes Enrollment in U.S. Phase IIa Study for Its Small Molecule Oral GLP-1R Agonist, ASC30, in Participants with Obesity or Overweight

–          13-week U.S. Phase IIa study is evaluating the efficacy, safety and tolerability of two oral formulations of ASC30, a once-daily tablet, in 125 participants with obesity or overweight.

–         All 125 participants enrolled in just over one month; topline data expected in the fourth quarter of 2025.

HONG KONG, Aug. 5, 2025 /PRNewswire/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces today completion of enrollment in its U.S. 13-week Phase IIa study evaluating ASC30, a small molecule oral GLP-1 receptor (GLP-1R) agonist for the treatment of obesity (NCT07002905). All 125 participants are obese or overweight with at least one weight-related comorbidity.

“We are excited to announce this important milestone, which brings us another step closer to delivering ASC30 as a potential unique and differentiated treatment for obesity,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, “The rapid pace of enrollment of 125 participants in just over one month underscores the unmet medical need for additional treatment options for obesity. We are looking forward to topline data from this Phase IIa study in the fourth quarter 2025. As a small molecule, ASC30 has the potential to offer both once-daily oral and once-monthly subcutaneous injection dosing options for obesity treatment, if approved.”

The Phase IIa study is a 13-week, randomized, double-blind, placebo-controlled and multi-center study to evaluate the efficacy, safety, and tolerability in participants with obesity (body mass index (BMI) ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2 but < 30 kg/m2) with at least one weight-related comorbidity. Two oral formulations of one-daily ASC30 are being evaluated: formulation 1 (ASC30 tablets) and formulation 2 (ASC30 tablets A1). The primary endpoint of the study is the mean percentage body weight change from baseline at Week 13. The 13-week study protocol has a low starting dose of 1 mg of both formulation 1 and formulation 2, with weekly titrations to the desired maintenance doses of 20 mg and 40 mg of formulation 1 or 20 mg, 40 mg and 60 mg of formulation 2.

Both formulations have been evaluated in the oral ASC30 Phase Ia single ascending dose (SAD) study (NCT06680440). Formulation 2 demonstrated a flatter pharmacokinetic profile compared to formulation 1.

ASC30 was discovered and developed in-house at Ascletis as a first and only investigational small molecule GLP-1R biased agonist designed to be dosed once daily orally and once monthly subcutaneously for the treatment of obesity.

About ASC30

ASC30 is an investigational GLP-1R biased small molecule agonist and has unique and differentiated properties that enable the same small molecule for both oral tablet and subcutaneous injection administrations. ASC30 is a new chemical entity (NCE), with U.S. and global compound patent protection until 2044 without patent extensions. 

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) Platform and Ultra-Long-Acting Platform (ULAP), Ascletis has developed multiple drug candidates in-house, including its lead program, ASC30, a small molecule GLP-1R agonist in development as a once-daily oral tablet and once-monthly subcutaneous injection for weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

To learn more about Ascletis, please visit www.ascletis.com.

Contact:

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com

Ascletis Pharma Inc. PR and IR teams
+86-181-0650-9129 (China)
pr@ascletis.com
ir@ascletis.com