SAN FRANCISCO and SUZHOU, China, Aug. 5, 2025 /PRNewswire/ — Innovent Biologics, Inc. (“Innovent”) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of oncology, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, announced that the U.S. Food and Drug Administration (FDA) has approved the investigational new drug (IND) application to initiate a Phase 1 clinical trial of IBI3032, the company’s novel oral GLP-1R agonist.

IBI3032 is an orally administered small-molecule GLP-1 receptor agonist with bias for cAMP signaling pathway, discovered and developed by Innovent Biologics with proprietary rights. Preclinical data demonstrate its superior pharmacokinetic (PK) and physicochemical properties compared to peer compounds. In animal models, IBI3032 achieved 5 to 10 times higher oral exposure at equivalent doses, with improved efficacy and good tolerability in both GLP-1R KI DIO mice and obese monkey models, achieving comparable therapeutic effects at lower doses.

The Phase 1 clinical trials of IBI3032 are planned to be conducted concurrently in China and the U.S. Dosing in healthy volunteers and overweight or obese participants is expected to begin in the second half of 2025. Innovent is building up its CVM pipeline with mazdutide as the cornerstone, and the initiation of the IBI3032 clinical study marks a significant step in the evolution of its CVM pipeline portfolio with global potential.

Dr. Lei Qian, Chief R&D Officer for General Biomedicines Pipeline at Innovent Biologics, said, “GLP-1 has emerged as a blockbuster target over the past decade. Its oral form, with its convenience, flexibility, and unique advantage in combination treatment strategies, holds promise as a differentiated complement to GLP-1R-targeting biologicals. Beyond traditional applications in diabetes and weight management, oral GLP-1 possess potential in treating related diseases such as hypertension and OSA (obstructive sleep apnea). IBI3032 has demonstrated its promising efficacy profiles in animal models, where IBI3032 exhibited a longer elimination half-life and higher drug exposure levels than its competitors at the same dose. We are excited to advance this candidate into clinical development. This IND approval reflects Innovent’s strong R&D capabilities and, most importantly, our commitment to global innovation. We hope that in the near future, IBI3032 can offer more effective and convenient treatment options to benefit patients around the world. “

About IBI3032

IBI3032 is a novel oral small molecule glucagon-like peptide-1 receptor agonist (GLP-1RA). By efficiently and selectively targeting GLP-1R, it activates downstream signal transduction, thereby delaying gastric emptying, inhibiting appetite, and promoting insulin secretion, and ultimately supporting the treatment of insulin-related metabolic diseases such as obesity and T2DB. Discovered through a structure-based drug design (SBDD) strategy combined with systematic physicochemical property optimization, IBI3032 has shown better PK and physicochemical properties compared to similar compounds.

The IND application of IBI3032 was accepted by China’s National Medical Products Administration (NMPA) and approved by the U.S. Food and Drug Administration (FDA). A multi-regional Phase 1 clinical study of IBI3032 is planned for initiation in the second half of 2025.

About Innovent Biologics

Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that target some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has launched 16 products in the market. It has 2 new drug applications under regulatory review, 4 assets in Phase III or pivotal clinical trials and 15 more molecules in early clinical stage. Innovent partners with over 30 global healthcare companies, including Eli Lilly, Sanofi, Incyte, LG Chem and MD Anderson Cancer Center.

Guided by the motto, “Start with Integrity, Succeed through Action,” Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.

Forward-Looking Statements

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words “anticipate”, “believe”, “estimate”, “expect”, “intend” and similar expressions, as they relate to Innovent Biologics, Inc. (“Innovent” or “Company”), are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company’s control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company’s competitive environment and political, economic, legal and social conditions.

The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialize or turn out to be incorrect.

PARIS, Aug. 5, 2025 /PRNewswire/ — A viral TikTok challenge known as “Burn Lines” or “Sunburn Tattoos” is gaining alarming traction among teenagers and young adults worldwide. The trend, which involves placing tape or stencils on the skin to intentionally burn patterned tan lines, has sparked widespread concern among global health experts.

Visual from La Roche-Posay underscores the serious risks of unprotected sun exposure. Contrary to popular perception, tan lines are not a harmless trend but a visible sign of skin damage. Prolonged exposure to UV rays without adequate protection can significantly increase the risk of skin cancer, including melanoma. This image forms part of La Roche-Posay’s ongoing efforts to raise awareness about sun safety and the importance of daily skin protection. Image courtesy of La Roche-Posay.

France’s Minister of Health stated recently: “For a few seconds of buzz on social media, young people are destroying their skin cells for life. We only get one skin.“

LA ROCHE-POSAY REAFFIRMS ITS LONGSTANDING COMMITMENT TO SKIN HEALTH
As a global leader in sun protection and skin cancer prevention, La Roche-Posay is worried about the long-term consequences of the Burn Lines challenge and aims at warning the public of how dangerous this practice can be, alongside health professionals.

Through its global Cancer Support program and Save Your Skin initiative, the brand promotes sun-safe habits and early detection, offering resources like free mole checks and public education campaigns.

SUPPORT FROM GLOBAL DERMATOLOGISTS
“As dermatologists, we are deeply concerned by the ‘Burn Lines‘ trends on social media” stated a group of leading dermatologists (see list at the end of release). “Such practices are not only reckless but directly contribute to irreparable skin damage, DNA damage & premature aging, and significantly increase the risk of skin cancer, including melanoma, one of the fastest-rising and deadliest cancers among young generation“.

A MESSAGE FROM EUROMELANOMA: PROTECTING THE NEXT GENERATION
“Just one blistering sunburn in childhood more than doubles the risk of skin cancer in adulthood” warns Véronique Del Marmol, President of Euromelanoma, a pan-European skin cancer prevention ressource center. “Yet 35% of parents rarely give their child protective clothing when exposed to the sun. On the other side, 57% of teenagers still associate tanning with attractiveness“.

With melanoma rates projected to rise by 40% by 2040, calling for immediate action to warn about this social media trend is without any doubt a true matter of public health.

GLOBALSKIN: CHAMPIONING THE PATIENT PERSPECTIVE
Jennifer Austin, CEO of GlobalSkin – the leading international not-for-profit organization dedicated to improving the lives of people living with skin conditions globally – adds, “Our member patient organizations witness firsthand the devastating impact of skin cancers and chronic sun damage on individuals and families. The ‘Burn Lines’ trends are a stark reminder of the misinformation prevalent online and the urgent need for clear, accessible and compassionate public education.”

This is why La Roche-Posay, alongside with world-class dermatologists and leading health associations, join forces to pursue the collective effort to educate on scientifically backed sun safety measures, such as wearing a hat, clothes with sleeves, sunglasses, and apply a broad-spectrum sunscreen SPF50+/UVA on uncovered body areas.

La Roche-Posay will amplify content on social media under #DermsAgainstBurns to create a positive movement around the critical importance of sun safe habits.

Last, we will relentlessly continue to advocate, with the medical community, towards authorities, policy makers and trade associations to promote responsible sun behavior.

ABOUT THE DERMATOLOGISTS THAT SUPPORT #DERMSAGAINSTBURNS MESSAGING

• Prof. Thierry Passeron, France – Chair, Dermatology Department, Nice University Hospital; melanoma and pigmentation researcher, expert in photoprotection
• Prof. Henry W. Lim, USA – Former Chair of Dermatology, Henry Ford Health; President, ILDS; expert in sunscreen and photoprotection
• Prof. Jorge Ocampo Candiani, Mexico – Former President, Mexican Society of Dermatological Surgery; incoming President, World Congress of Dermatology 2027
• Prof. Sergio Schalka, Brazil – Chair, Latin American Alliance for Photoprotection; lead, Brazilian Consensus on Photoprotection, expert in photoprotection

ABOUT LA ROCHE-POSAY, EUROMELANOMA & GLOBAL SKIN
For more information and resources on sun protection and melanoma awareness, please visit La Roche-Posay’s Save Your Skin initiative, Euromelanoma and GlobalSkin websites.

NEW YORK, Aug. 5, 2025 /PRNewswire/ — High-Trend International Group (the “Registrant” or the “Company”) (NASDAQ: HTCO), a global ocean technology company is reporting that its board of directors (the “Board”) has approved a reverse stock split (the “Reverse Stock Split”) of the Company’s Class A ordinary shares, a par value of US$0.0001 each (the “Ordinary Shares”), at a ratio of 1-for-25 (the “Reverse Split Ratio”), with a post-Reverse Stock Split par value of US$0.0025.

The Company is undertaking the Reverse Stock Split with the objective of meeting the minimum $1.00 per Ordinary Share bid requirement for maintaining the listing of the Ordinary Shares on The Nasdaq Capital Market.

The Reverse Stock Split will be effective at 04:01 p.m. (ET) on Thursday August 7, 2025 (the “Record Date”) and the Ordinary Shares will begin trading on a split-adjusted basis when the Nasdaq Stock Market LLC opens for trading on Friday, August 8, 2025. The Ordinary Shares will continue to trade on The Nasdaq Capital Market under the trading symbol “HTCO” but will trade under the following new CUSIP number: G1901X 116.

As a result of the Reverse Stock Split, every 25 Ordinary Shares held as of the Record Date will be automatically combined into one Ordinary Share. The number of outstanding Ordinary Shares will be reduced from approximately 140,000,000 Ordinary Shares to approximately 5,600,000 Ordinary Shares. No fractional shares will be created or issued in connection with the reverse stock split.

The Reverse Stock Split will affect all holders of Ordinary Shares uniformly and will not affect any shareholder’s percentage ownership interest in the Company.

Shareholders with Ordinary Shares held in book-entry form or through a bank, broker, or other nominee are not required to take any action and will see the impact of the Reverse Stock Split reflected in their accounts on or after August 8, 2025. Such beneficial holders may contact their bank, broker, or nominee for more information.

Forward-Looking Statements

This current report on Form 6-K contains “forward-looking statements” within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). The forward-looking statements can be also identified by terminology such as “may,” “might,” “could,” “will,” “aims,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates” and similar statements.

These forward-looking statements are based on our current assumptions, expectations and beliefs and involve substantial risks and uncertainties that may cause results, performance or achievement to materially differ from those expressed or implied by these forward-looking statements. These statements are not guarantees of future performance and are subject to a number of risks. The reader should not place undue reliance on these forward-looking statements, as there can be no assurances that the plans, initiatives or expectations upon which they are based will occur. A detailed discussion of factors that could cause or contribute to such differences and other risks that affect our business is included in filings we make with the Commission from time to time, including our most recent report on Form 20-F, particularly under the heading “Risk Factors”.

Market-leading innovation, AI-enabled project intelligence^™, and a customer-first approach are transforming the AEC project management industry.

SAN ANTONIO, Aug. 4, 2025 /PRNewswire/ — Frost & Sullivan is pleased to announce that BST Global has received the 2025 Global Company of the Year Award in the architecture, engineering, and consulting (AEC) project management industry for its outstanding achievements in innovation, performance, and customer impact. This top honor recognizes BST Global’s leadership in transforming the AEC project management landscape through cutting-edge technology and a customer-centric business model.

Frost & Sullivan evaluates companies through a rigorous benchmarking process across two core dimensions: strategy effectiveness and strategy execution. BST Global excelled in both, demonstrating its ability to align strategic initiatives with emerging AEC market demands—such as increasing project complexity and skilled workforce shortages—while executing them with scale and precision.

Guided by a long-term strategy focused on digital transformation and customer satisfaction, BST Global has reshaped how AEC firms manage project performance. With AEC companies facing industry-wide challenges—from rising material costs and labor shortages to increasingly remote operations and outdated legacy systems—BST Global delivers intuitive, AI-powered solutions that reduce complexity, improve decision making, and increase productivity.

Innovation remains at the core of BST Global’s approach. The company’s AI-enabled project intelligence platform includes BST Insights, which leverages more than 35 discrete digital signals to provide real-time visibility into project health using net labor multiplier (NLM) as a predictive KPI.

“BST Insights predicts outcomes with a 95% or higher accuracy rate for qualified projects, enabling project managers and project directors to make meaningful changes to how their projects are resourced in real time, for example, identifying roles that can be staffed more cost effectively to better align with the economic footprint of the project,” said Lynda Stadtmueller, Associate Partner, Information & Communications Technology, Frost & Sullivan.

BST Global also introduced BST Connect^™, a cloud-based iPaaS launched in 2024. It integrates seamlessly with systems such as Oracle CX and Microsoft Dynamics, enabling enterprise-wide connectivity.

“Earning this honor from Frost & Sullivan reflects the transformative work our team and our clients are doing together to redefine project management in the AEC industry,” said Eileen M. Canady, Chief Marketing Officer at BST Global. “We’re proud to lead with innovation—infusing AI and real‑time insights into project delivery—while never losing sight of what matters most: enabling our clients to thrive in an increasingly complex and competitive environment.”

BST Global’s consumer-grade mobile applications and Waze-inspired user interface reduce training time and accelerate user adoption. Whether clients are migrating from on-premises solutions or embracing BST Global’s latest cloud-native platforms, the company supports them with tailored implementation, data migration, and ongoing reporting services to ensure a smooth, effective transition.

Frost & Sullivan commends BST Global for setting the standard in market responsiveness, ecosystem collaboration, and customer experience. The company’s launch of the AI + Data Consortium in October 2024 further demonstrates its commitment to advancing the AEC industry through collective benchmarking and standard setting.

Each year, Frost & Sullivan presents the Company of the Year Award to a company that demonstrates outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning. The honor recognizes forward-thinking organizations that are reshaping their industries through innovation and growth excellence.

Frost & Sullivan Best Practices Awards

Frost & Sullivan’s Best Practices Awards honor companies across regional and global markets that exhibit exceptional achievement and consistent excellence in areas such as leadership, technological innovation, customer experience, and strategic product development. Each recognition is the result of a rigorous analytical process in which Frost & Sullivan industry experts benchmark performance through comprehensive interviews, deep-dive analysis, and extensive secondary research. The goal is to identify true best-in-class organizations that are driving transformative growth and setting new industry standards.
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Contact:

Camila Tinajero
E: camila.tinajero@frost.com 

About BST Global 

BST Global designs, develops and deploys the AEC industry’s first suite of AI-powered project intelligence^™ solutions. Beyond our flagship ERP offering, we provide work management, predictive insights and resource management solutions to complement a firm’s existing ERP. More than 120,000 architects, engineers and consultants in 65 countries across six continents rely on BST Global’s solutions each day to successfully manage their projects, resources, finances and client relationships. With unrivaled industry knowledge, BST Global serves as a trusted partner to its loyal clients and remains at the forefront of innovation. For more information, visit www.BSTGlobal.com.