PRINCETON, N.J. and TOKYO, July 29, 2025 /PRNewswire/ — Kyowa Kirin Co., Ltd. (TSE: 4151) today announced that results of the Phase 3 ROCKET IGNITE trial of rocatinlimab, an investigational therapy targeting the OX40 receptor (OX40R) in patients with moderate-to-severe atopic dermatitis (AD), will be presented at the European Academy of Dermatology and Venereology (EADV) 2025 Annual Meeting to be held in Paris, France from September 17-20, 2025.

AD, a chronic, heterogeneous, inflammatory disease characterized by skin redness, pruritus, and pain, is driven by skin barrier disruption and T-cell-dependent inflammatory pathways. Expansion of OX40R+ pathogenic T cells leads to T-cell imbalance, a root cause of inflammatory diseases including AD.

Title: Efficacy & Safety of OX-40 Receptor Targeting with Rocatinlimab in Moderate-to-Severe Atopic Dermatitis: Results from the Phase 3 ROCKET-IGNITE Trial

Presenter: Emma Guttman-Yassky, MD, PhD

Date: Friday, September 19^th
Time: 4:40 – 4:50 pm CEST
Session: FC 08 Atopic Dermatitis
Location: Paris Convention Centre, Pavillon 7.3, Room W05-W06

About the ROCKET Phase 3 Program
ROCKET is a comprehensive, global Phase 3 clinical trial program comprised of eight studies intended to establish the safety and efficacy profile of rocatinlimab in adults and adolescents with moderate to severe atopic dermatitis (AD) as well as multiple dosing regimens.

About Moderate to Severe Atopic Dermatitis
Atopic dermatitis, the most common form of eczema, is a chronic inflammatory disease that causes excessively dry, itchy skin that can be painful. People with moderate to severe atopic dermatitis experience chronic symptoms, intensified by unpredictable flare-ups that can be painful and disruptive to everyday life. More than half of these patients report severe itching, leading to repeated scratching which can cause the skin to thicken and become vulnerable to infection. Atopic dermatitis (all severities) affects 15-20% of children and up to 10% of adults. T-cell imbalance is a root cause of atopic dermatitis, contributing to clinical manifestations including the disease’s recurring, unpredictable symptoms.

About Rocatinlimab
Rocatinlimab is an anti-OX40 human monoclonal antibody being investigated for the treatment of moderate to severe atopic dermatitis. Rocatinlimab has the potential to be the first and only T-cell rebalancing therapy that inhibits and reduces pathogenic T cells by targeting the OX40 receptor. OX40 is a co-stimulatory receptor responsible for driving systemic and local inflammatory responses in atopic dermatitis and other conditions. It has been reported that effector T cells expressing OX40 are present in the lesions of patients with atopic dermatitis and are critical in the disease pathophysiology.

Rocatinlimab is also being studied for prurigo nodularis, moderate to severe uncontrolled asthma and potentially other conditions where T-cell imbalance is a root cause of inflammation. The initial antibody was discovered in collaboration between Kyowa Kirin and La Jolla Institute for Immunology.

Rocatinlimab is currently under clinical investigation, and its safety and efficacy have not been evaluated by the U.S. FDA or any other regulatory authority.

About Kyowa Kirin
Kyowa Kirin aims to discover and deliver novel medicines and treatments with life-changing value. As a Japan-based Global Specialty Pharmaceutical Company, we have invested in drug discovery and biotechnology innovation for more than 70 years and are currently working to engineer the next generation of antibodies and cell and gene therapies with the potential to help patients with high unmet medical needs, such as bone & mineral, intractable hematological diseases/hemato oncology, and rare diseases. A shared commitment to our values, to sustainable growth, and to making people smile unites us across the globe. You can learn more about the business of Kyowa Kirin at: https://www.kyowakirin.com/.   

Amgen and Kyowa Kirin Collaboration
On June 1, 2021, Kyowa Kirin and Amgen entered into an agreement to jointly develop and commercialize rocatinlimab. Under the terms of the agreement, Amgen will lead the development, manufacturing, and commercialization for KHK4083/AMG 451 for all markets globally, except Japan, where Kyowa Kirin will retain all rights. If approved, the companies will co-promote the asset in the United States and Kyowa Kirin has opt-in rights to co-promote in certain other markets including Europe and Asia.

CONTACT:

Kyowa Kirin
Hiroki Nakamura: Japan
Corporate Communications Department
media@kyowakirin.com

Subrenie Thomas-Smith: North America
Sr. Director, R&D Patient Engagement & Communications
subrenie.thomas-smith.8c@kyowakirin.com

MIDDLETON, Wis., July 29, 2025 /PRNewswire/ — Leo Cancer Care, a leader in upright radiotherapy solutions, today announces that its flagship product, Marie®, has received 510(k) clearance from the U.S. Food and Drug Administration (FDA).

Marie represents a paradigm shift in the delivery of particle therapy, combining an upright patient positioning system and a CT scanner that reimagines the treatment experience for both patients and clinicians, whilst drastically reducing the size and cost compared to existing particle therapy solutions.

Marie, Leo Cancer Care’s Upright Particle Therapy Solution

“This clearance marks a major milestone not just for Leo Cancer Care, but for the future of cancer treatment,” said Stephen Towe, CEO of Leo Cancer Care. “We’ve long believed there’s a better, more human way to deliver radiotherapy. One that puts the patient at the heart of the treatment experience and embraces smarter, more compassionate design. Marie is the embodiment of that belief.”

Particle therapies such as proton and carbon ion therapy have long been considered the gold standard in radiation oncology. However, the cost, size, and complexity of conventional systems with large rotating gantries have historically limited widespread adoption.

Leo Cancer Care’s upright solution addresses these barriers. By rotating the patient rather than the beam, Marie eliminates the need for a rotating gantry, dramatically reducing infrastructure costs, simplifying installation, and expanding access to this advanced level of care.

Marie is particle beam-agnostic, meaning it’s compatible with a wide range of current and emerging treatment modalities, including proton, carbon ion, BNCT and FLASH therapies. Its upright design opens new possibilities for treatment planning and delivery, particularly for tumors in the thoracic and abdominal regions. When compared to supine treatments, evidence suggests anatomical shifts are reduced due to the gravitational direction.

Through collaborations with leading hospitals around the world, Leo Cancer Care is conducting clinical research and trials, laying a strong foundation for the widespread adoption of upright therapy as a new standard in radiotherapy.

“We are incredibly proud of the teams and collaborators who helped bring Marie to life,” added Thomas ‘Rock’ Mackie, Co-founder and Board Chairman of Leo Cancer Care. “This is just the beginning. We’re working closely with leading particle beam companies and institutions worldwide to explore how upright positioning can unlock new levels of precision and personalization in cancer care.”

Media Contact:
Fiona Redford
Head of Marketing
Leo Cancer Care
fiona@leocancercare.com

KUALA LUMPUR, Malaysia, July 29, 2025 /PRNewswire/ — Bitget, the leading cryptocurrency exchange and Web3 company, hosted a yoga retreat meet up under its Blockchain4Her initiative during Malaysia Blockchain Week 2025. The event, Blockchain4Her: Pengu Yoga Flow with Gracy Chen, the session partnered with Pudgy Penguins to connect over 25 female founders, developers, and executives for a yoga session that followed with a talk by Gracy industry discussions.

Held at The Flow Studio in KLGCC, this marked Blockchain4Her’s first sports-themed event, blending physical wellness with professional networking in an industry where women hold just 26% of leadership roles.

Gracy sharing her experiences with the attendees at the Blockchain4Her: Pengu Yoga Event

Gracy Chen,CEO at Bitget and founder of Blockchain4Her, said. “Web3 needs women at every level, not just as participants but as builders, leaders and founders,” she said. “Today was about strengthening both body and mind but also about building your professional networks.”

Blockchain4Her is growing globally, driven by its recent three-year partnership with UNICEF as part of the Game Changers Coalition. The initiative delivers blockchain and digital skills training to 300,000 young people, including girls and educators, across eight countries, with Malaysia as one of the key hubs. Through Bitget Academy, UNICEF’s first blockchain curriculum combines online modules, hands-on workshops, and game-based learning, reinforcing Blockchain4Her’s focus on delivering impact and bringing change to the lives of those involved.

The event attracted a diverse group of women from ASEAN’s Web3 scene, demonstrating strong interest in regular, substantive programming. The Pudgy Penguins collaboration advanced Bitget’s strategy of combining cultural relevance with inclusion, following their recent “Kopi Rave” side event during MYBW 2025.

About Bitget

Established in 2018, Bitget is the world’s leading cryptocurrency exchange and Web3 company. Serving over 120 million users in 150+ countries and regions, the Bitget exchange is committed to helping users trade smarter with its pioneering copy trading feature and other trading solutions, while offering real-time access to Bitcoin price, Ethereum price, and other cryptocurrency prices. Formerly known as BitKeep, Bitget Wallet is a leading non-custodial crypto wallet supporting 130+ blockchains and millions of tokens. It offers multi-chain trading, staking, payments, and direct access to 20,000+ DApps, with advanced swaps and market insights built into a single platform.

Bitget is driving crypto adoption through strategic partnerships, such as its role as the Official Crypto Partner of the World’s Top Football League, LALIGA, in EASTERN, SEA and LATAM markets, as well as a global partner of Turkish National athletes Buse Tosun Çavuşoğlu (Wrestling world champion), Samet Gümüş (Boxing gold medalist) and İlkin Aydın (Volleyball national team), to inspire the global community to embrace the future of cryptocurrency.

Aligned with its global impact strategy, Bitget has joined hands with UNICEF to support blockchain education for 1.1 million people by 2027. In the world of motorsports, Bitget is the exclusive cryptocurrency exchange partner of MotoGP™, one of the world’s most thrilling championships.

For more information, visit: Website | Twitter | Telegram | LinkedIn | Discord | Bitget Wallet

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SINGAPORE, July 29, 2025 /PRNewswire/ — On July 27, 2025, POP MART successfully hosted a 5km themed run in Singapore, drawing over 3,000 enthusiastic participants. As part of the annual Lazada Run series, the event was held against the scenic backdrop of Marina Barrage, where fans crossed the finish line and engaged in photo ops, mini-games, and immersive experiences with Twinkle Twinkle, POP MART’s beloved IP character in Southeast Asia.

This partnership marks a key milestone in POP MART’s year-round collaboration with Southeast Asia’s leading e-commerce platform Lazada. Lazada Run, first launched in 2023, is one of the platform’s flagship initiatives, spanning Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. After two years of successful operation, POP MART joined Lazada Run in 2025 to bring a more dynamic, immersive IP experience to runners across the region, integrating into multiple physical and digital touchpoints.

To date, POP MART has successfully completed the Philippines leg on June 1, the Vietnam race on July 13, and now the Singapore run on July 27. Each location saw overwhelming fan enthusiasm, with the Twinkle Twinkle experience zone emerging as a major highlight and social media hotspot, significantly enhancing brand visibility and emotional resonance. At the Singapore event, POP MART further enriched the on-site experience by introducing a giant Twinkle Twinkle inflatable at the Runners’ Village, drawing crowds for photos and fan interactions. A “Best Dressed” contest also encouraged runners to showcase POP MART-inspired looks — from playful costumes to limited-edition merch — celebrating creativity and deepening fan-brand connection.

In addition to Lazada Run, POP MART and Lazada will co-launch the Super Brand Day campaign in late August across five Southeast Asian countries — Singapore, Malaysia, Thailand, the Philippines, and Vietnam, which will also coincide with the opening of PTS (Pop Toy Show) events in Singapore later, combining a seamless online and offline exposure. With Lazada offering full-platform promotional support, including exclusive gifts and trending product launches, the collaboration aims to drive both engagement and sales at scale.

Looking ahead, the Lazada Run x POP MART tour will continue in Malaysia, Thailand, and Indonesia from October to December. Through this year-long partnership, POP MART not only strengthens its IP exposure in Southeast Asia but also builds emotional resonance with emerging audiences — laying the groundwork for its next generation of global breakout characters.

SEATTLE, July 29, 2025 /PRNewswire/ — Govee, a global leader in smart lighting innovation, today announces the launch of the Govee Outdoor UpDown Wall Light, the industry’s first all-around dynamic wall light featuring independently adjustable colors on all four sides. Built for those seeking immersive ambiance and advanced smart features, this fixture brings a vibrant, customizable glow to any outdoor space — from cozy decks to expansive patios.

All-Around Dynamic Lighting Elevate Outdoor Living

Featuring four adjustable sections, this wall light brings enriched colors and 360° dynamic lighting effects to your outdoor space. The up and down beams feature the RGBWW technology while the right and left sides feature the RGBIC technology, offering stunning 16 million colors or bright white light with endless possibilities to elevate your outdoor space. With 64 preset scenes and 19 DIY modes, users have complete control to curate the perfect lighting for any occasion. Whether you prefer a refined, effortless scene or a vibrant color in every detail, the dynamic and easy-to-use system offers flexibility for all without complexity.

1200lm Brightness for a Comfortable, Balanced Glow

Whether you’re illuminating a dinner setting or setting the mood for a quiet evening outdoors, this fixture provides ample brightness while maintaining a warm and comfortable atmosphere. The adjustable color temperature lets you tailor the light to match any occasion, while the wall-washing design eliminates harsh glares, delivering gentle illumination that enhances rather than overwhelms.

Expansive Updown Beams with Elevated Impact

With wide-coverage beams that outshine standard alternatives, illuminate your home’s architectural details to create a dramatic and visually appealing effect. Delivering wider light coverage than typical outdoor fixtures, the Govee Updown Wall covers a maximum wall-washing area of 12 square meters, making it ideal for illuminating and decorating large wall surfaces — creating a bold, eye-catching statement.

Smart Control with Matter and AI-Powered Customization

Like all Govee lights, the new outdoor lighting solutions offer seamless smart control and ecosystem integration. Control your lights effortlessly using the Govee Home App, voice commands through Amazon Alexa or Google Home, or expand your setup with Matter compatibility. Whether you’re adjusting the lighting remotely, setting schedules, or integrating with other smart devices, managing your outdoor lighting is intuitive and hassle free.  Plus, the AI Lighting Bot offers AI-generated lighting suggestions to add a layer of creative inspiration — perfectly adapting scenes to match your environment and mood.

Built to Withstand the Elements

Engineered for longevity, this light is IP66 waterproof and UV resistant, ensuring reliable performance in rain, snow, or intense sunlight. It’s the perfect wall-mounted solution for year-round use — where traditional lighting might fail.

Pricing and Availability

Govee Outdoor UpDown Wall Light will be available on July 29, on the Govee website and Amazon for $129.99 (one pack) or $229.99 (two pack).

For more details about the brand, please visit govee.com.

About Govee

Govee has been revolutionizing the smart living experience since 2017, with innovative, efficient, and hassle-free ambient lighting solutions for the entire home. From living spaces and gaming setups to outdoor areas and beyond, Govee smart lighting is not just visually stunning, but transforms everyday moments into personalized and engaging lighting experiences. Embracing the idea that “Life is colorful,” Govee is committed to bringing vibrant ambient lighting to every corner of the home, to fostering connections with users on both practical and emotional levels, and to making everyday moments brighter and more enjoyable.

SHENZHEN, China, July 29, 2025 /PRNewswire/ — As a global leader in folding bicycles, DAHON has always been driven by innovation. Following strong industry recognition after over a year of global exhibitions and media promotion, DAHON officially announces the renaming of its “D-VELO” technology to DAHON-V.

The “V” stands for “Victory,” symbolizing the evolution and triumph of DAHON’s advanced engineering.

Origins and Innovation

DAHON-V technology stems from a critical “rethinking” of traditional bicycle frame design, leading to a suite of technology and testing methods engineered to improve the speed of both folding and road bikes:

• Folding Bikes:
  Introducing the DELTECH and Super Down Tube, DAHON significantly enhanced frame stiffness, overcoming the typical weakness of single-beam folding frames. As a result, the bikes deliver faster speeds, greater safety, and enhanced durability.
• Road Bikes:
  Applying DAHON-V principles, DAHON optimized frame structures to minimize power loss, delivering greater efficiency, stiffness, and riding performance.

Product Highlights

DAHON unveiled a lineup of innovative new products at EUROBIKE 2025 in Frankfurt, Germany, drawing widespread attention with its DAHON 2.0 Campaign backed by its proprietary DAHON-V bike tech promising improved performance across all lines of products.

Taking the spotlight at the show include the following products:

Télodon C8 AXS: A folding carbon road bike combining portability with high-speed performance, featuring the internal V-lock system and enhanced frame stiffness.

Vélodon C8 Di2: DAHON’s first full carbon road bike equipped with DAHON-V technology, including SRAM electronic shifting and UDH system, built for pure speed.

Major media outlets such as Global Cycling Network (GCN) and BikeRadar also graced the occasion to report on the product showcase.

Future Outlook

Looking ahead, DAHON will continue to expand the DAHON-V through:

• Advanced material development (carbon composites and high-performance alloys)
• Smart integration (adaptive e-bike systems)
• Ecosystem building (standardizing DAHON-V technology across all categories)

Through strategic partnerships with research institutions and industry leaders, DAHON is committed to shaping the future of cycling — delivering lighter, faster, and smarter mobility solutions for riders worldwide.

For more information, please contact marketing@dahon.com

www.dahon.com