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Hong Kong reclaims top global IPO spot in 2025, says KPMG

Record A+H listings drive historic year, pipeline of over 300 signals sustained momentum into 2026


HONG KONG SAR – Media OutReach Newswire – 10 December 2025 – Hong Kong has reclaimed the top spot in global IPO market rankings for the first time since 2019, driven by a record number of A+H listings that contributed over half of total funds raised, according to KPMG’s latest Chinese Mainland and Hong Kong IPO Markets 2025 Review and 2026 Outlook. With an all-time high of more than 300 active IPO applications in the pipeline as at 7 December 2025 – including 92 active A+H listing applicants – Hong Kong is well positioned to maintain its IPO momentum into 2026.

In 2025, global IPO markets raised USD158.4 billion across 1,227 deals, reflecting a 18% rise in funds raised and a 4% drop in deal volume compared to 2024. Hong Kong led the way, followed by the US stock exchanges in second and third place, which saw their combined fundraising grow by 18% year-on-year. Rounding out the top five were the National Stock Exchange of India and the Shanghai Stock Exchange, securing the fourth and fifth places, respectively.

Paul Lau, Partner, Head of Capital Markets and Professional Practice, KPMG in China, says, “Key global IPO markets have trended upwards in 2025 with Hong Kong’s threefold increase in funds raised making it the largest single contributor to the global IPO market’s recovery and reaffirming its status as a leading international financial centre. Buoyed by this momentum and a backlog of potential IPO candidates, we expect this upward trend to continue into 2026. In particular, the pace of AI-related listings is poised to accelerate as the technology matures and is adopted more widely across various industries.”

The A-share market continues its steady development, expected to raise RMB163.7 billion across 130 deals, representing a 23% growth in funds raised while deal volume remained stable compared to 2024. The listing of 20 Real Estate Investment Trusts (REITs) remains a significant driver, securing RMB41.0 billion in funding, which accounts for 25% of the total A-share proceeds in 2025.

The Shanghai Stock Exchange STAR Market saw substantial reforms during the year, including the launch of a science and technology innovation growth tier in July. Since then, 3 pre-profit companies – primarily from the semiconductor and biotechnology sectors – have been listed in the growth tier. These reforms aim to help early-stage, high-quality companies utilise capital to accelerate the commercialisation of technology and enhance overall industrial capabilities.

Irene Chu, Partner, Head of New Economy and Life Sciences, Hong Kong SAR, KPMG in China, says: “The A-share IPO market posted steady gains in 2025. The 15th Five-Year Plan deepens the reform for China’s capital markets, with inclusiveness and coordinated investment and financing at the core of market reforms. As these strategic priorities take hold, we expect the authorities to prioritise and sustain their efforts to foster steady, high-quality growth in the A-share market for years to come.”

The Hong Kong IPO market delivered a standout performance in 2025, with funds raised expected to reach HK$272.1 billion across 100 listings. This would represent increases of 210% and 43% respectively compared to 2024, marking the strongest year in terms of funds raised since 2022. The growth was driven by the rise of A+H listings, which accounted for half of total IPO funds raised.

A record 17 A+H listings were completed in 2025, the highest number on record, highlighting Hong Kong’s strength as a bridge between domestic and global capital pools. The surge was fueled by strong government policy support and the momentum established by successful mega-sized A+H listings recently. Among them, the world’s largest EV battery manufacturer raised HK$41.0 billion through its A+H listing, making it the largest IPO globally in 2025.

The city hosted 14 pre-revenue biotech listings (Ch.18A) in 2025, up from 4 in 2024, along with 3 specialist technology listings (Ch.18C), on par with the previous year. The launch of the Technology Enterprises Channel (TECH) and the option for confidential submissions for Ch.18A and Ch.18C companies, has streamlined and improved the listing process. These improvements underscore the city’s dedication to fortifying its status as a leading global listing platform.

Active IPO applications in Hong Kong reached a record 316 as at 7 December 2025, a 267% increase from the end of 2024. Within this pipeline, 92 are A+H applications. When combined with A-share companies that have announced their intention to list in Hong Kong, we may be seeing over a hundred A+H listings applications in the near future, providing an anticipated robust start to 2026.

Amendments to the eligibility requirements for companies with weighted voting rights (WVR) structures are currently being considered, with potential enhancements including: lowering market capitalisation requirements, revising the Innovative Company definition, and adjusting voting power restrictions. These changes aim to enable more companies to utilise the regime and afford greater flexibility for founders. A crucial aspect will be striking the right balance between offering flexibility to potential issuers and safeguarding investor interests.

Louis Lau, Partner, Head of Hong Kong Capital Markets Group, KPMG in China, says: “Hong Kong’s return to the top of global IPO rankings has demonstrated the resilience of its capital market and its role as an international financial centre. We are witnessing a steady influx of tech and biotech firms opting to list in Hong Kong, drawn by the city’s supportive policies and stable regulatory environment. Rising participation from foreign investors further emphasises Hong Kong’s growing appeal as a gateway to Chinese assets and high-tech investment opportunities. As policies continue to promote innovation and new economy sectors, aside from the continued momentum from A+H listings, we also expect 2026 to be a pivotal year for high-tech listings, further solidifying Hong Kong’s position as a global capital markets leader.”

Remark: All figures and data referenced in this press release and the related report are as at 7 December 2025, adjusted for confirmed listings up to 31 December 2025.Hashtag: #KPMG

The issuer is solely responsible for the content of this announcement.

About KPMG

KPMG in China has offices located in 31 cities with over 14,000 partners and staff, in Beijing, Changchun, Changsha, Chengdu, Chongqing, Dalian, Dongguan, Foshan, Fuzhou, Guangzhou, Haikou, Hangzhou, Hefei, Jinan, Nanjing, Nantong, Ningbo, Qingdao, Shanghai, Shenyang, Shenzhen, Suzhou, Taiyuan, Tianjin, Wuhan, Wuxi, Xiamen, Xi’an, Zhengzhou, Hong Kong SAR and Macau SAR. It started operations in Hong Kong in 1945. In 1992, KPMG became the first international accounting network to be granted a joint venture licence in the Chinese Mainland. In 2012, KPMG became the first among the “Big Four” in the Chinese Mainland to convert from a joint venture to a special general partnership.

KPMG is a global organisation of independent professional services firms providing Audit, Tax and Advisory services. KPMG is the brand under which the member firms of KPMG International Limited (“KPMG International”) operate and provide professional services. “KPMG” is used to refer to individual member firms within the KPMG organisation or to one or more member firms collectively.

KPMG firms operate in 142 countries and territories with more than 275,000 partners and employees working in member firms around the world. Each KPMG firm is a legally distinct and separate entity and describes itself as such. Each KPMG member firm is responsible for its own obligations and liabilities.

Hong Kong Kicks Off One-Year Countdown to the XXVIII ANOC General Assembly 2026

Preparation for Prestigious International Meeting Accelerates


HONG KONG SAR – Media OutReach Newswire – 10 December 2025 – The Steering Committee for the XXVIII Association of National Olympic Committees (ANOC) General Assembly today hosted a one-year countdown kick-off press conference at the Royal Hong Kong Yacht Club, signalling a significant milestone in the preparations for this prestigious international event. Supported by the Government of the Hong Kong Special Administrative Region, the event is marking its inaugural staging in Hong Kong.

The One-Year Countdown Kick-Off Press Conference of the XXVIII ANOC General Assembly took place today. Officiating guests who launched the event included (from left) Mr Kenneth FOK, Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Vice President of SF&OC; Mrs Gunilla LINDBERG, ANOC Secretary General, International Olympic Committee Member; and Mr Edgar YANG, Vice Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Hon. Secretary General, SF&OC.
The One-Year Countdown Kick-Off Press Conference of the XXVIII ANOC General Assembly took place today. Officiating guests who launched the event included (from left) Mr Kenneth FOK, Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Vice President of SF&OC; Mrs Gunilla LINDBERG, ANOC Secretary General, International Olympic Committee Member; and Mr Edgar YANG, Vice Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Hon. Secretary General, SF&OC.

The XXVIII ANOC General Assembly is scheduled to take place in Hong Kong, China, from 7 to 10 December 2026 at AsiaWorld Expo. This landmark gathering is anticipated to welcome over 1,200 sports leaders, dignitaries, and representatives from 206 National Olympic Committees, the International Olympic Committee, International Federations, and Organising Committees of the Olympic Games. The Assembly’s agenda will also feature thematic seminars and diverse exchange events. A key highlight will be the prestigious ANOC AWARDS 2026. This anticipated event will acknowledge the outstanding achievements of athletes and members of the sports community during the Olympic Winter Games Milano Cortina 2026.

The press conference was hosted by distinguished guests, including Mrs Gunilla LINDBERG, ANOC Secretary General, International Olympic Committee Member; Mr Kenneth FOK, Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Vice President of SF&OC; and Mr Edgar YANG, Vice Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Hon. Secretary General of SF&OC.

Miss Rosanna LAW, Secretary for Culture, Sports and Tourism, said in the opening video, “In just one year, Hong Kong will have the honour of hosting the 2026 ANOC General Assembly—one of the most important conferences in the world of sports. We are so excited to welcome you and showcase the very best of our city: from our world-class venues and cutting-edge infrastructure to our vibrant culture and, most importantly, our famous Hong Kong hospitality. We can’t wait to see you here in Hong Kong next year!”

Mrs Gunilla LINDBERG, ANOC Secretary General, International Olympic Committee Member, said, “We’re delighted with how preparations are progressing. The close cooperation with the Sports Federation & Olympic Committee of Hong Kong, China, the Steering Committee of the XXVIII ANOC General Assembly Hong Kong, China, 2026 and local authorities is excellent. Along with the other key stakeholders, we are working as one team. This gives us great confidence that this will be an excellent General Assembly, which showcases the solidarity among NOCs and addresses the challenges and opportunities the Olympic Movement will face in the coming years.”

Mr Kenneth FOK, Chairperson of XXVIII ANOC GA HK, China, 2026 Steering Committee cum Vice President of SF&OC, added, “One year from today, Hong Kong, renowned as Asia’s mega-event capital and a dynamic bridge between East and West, will host the XXVIII ANOC General Assembly 2026. This event, made possible by the unwavering support of the Government of the HKSAR, is set to transform our city into an unparalleled international platform. Our goal is to collaboratively forge a global blueprint for sport’s future, generating profound economic, social, and sporting impact on a global scale.”

Both ANOC and the Steering Committee reaffirm their commitment to close collaboration, ensuring the smooth and successful delivery of the General Assembly. This event powerfully underscores Hong Kong’s role as Asia’s mega-event capital and a world-class MICE destination, reinforcing its influential global sports standing and capacity for major international collaboration. This strategic positioning enables the city to actively promote the sports industry and deepen international exchanges and cooperation, uniquely connecting the Hong Kong, China and the world.
Hashtag: #XXVIIIANOC

The issuer is solely responsible for the content of this announcement.

About the Association of National Olympic Committees (ANOC)

Established in June 1979, the Association of National Olympic Committees (ANOC) is the umbrella organisation responsible for protecting and advancing the interests of the world’s National Olympic Committees (NOC), and for supporting their mission to promote the Olympic Values worldwide.

ANOC’s vision is to connect and empower the voice of the NOCs of the world and promote the wellbeing of their athletes. It aims to achieve this through collaboration, development, representation and events, providing the best possible support to its NOCs and ensuring that their interests are protected and advanced on the global stage.

ANOC develops initiatives and services that provide solutions to common challenges and maximise value for NOCs across their day-to-day operations. By facilitating the sharing of best practices between NOCs and developing connections with International Federations and Olympic stakeholders, ANOC enables the collective development of the entire NOC family.

About the ANOC General Assembly

The ANOC General Assembly is the supreme decision-making body of ANOC and brings the world’s NOC’s together to share ideas, discuss priorities and plan for the future. The General Assembly has been hosted all around the world. Recent host cities include: Cascais, Portugal (2024), Seoul, Republic of Korea (2022).

ANOC’s member NOCs are entitled to participate in the General Assembly, represented by their delegates, in addition to the members of the Executive Council of ANOC. Representatives from the International Olympic Committee (IOC), International Federations (IFs), Organising Committees of Olympic Games (OCOGs) and other Olympic stakeholders are also invited to attend the General Assembly. Apart from the General Assembly, ANOC also invites partners and exhibitors (from the business field) to explore commercial interests and opportunities.

Every four years the General Assembly elects the President, the Senior Vice-President, and other members of the Executive Council. At the upcoming XXVIII ANOC General Assembly Hong Kong, China, 2026, elections will be conducted.

Professor Youmin Xi honoured with University of Liverpool Fellowship

SUZHOU, China, Dec. 10, 2025 /PRNewswire/ — Professor Youmin Xi, Executive President of Xi’an Jiaotong-Liverpool University (XJTLU), has received an Honorary Fellowship from the University of Liverpool.

The award recognises his success in leading XJTLU – an innovative partnership between the University of Liverpool in the UK and Xi’an Jiaotong University in China – and his significant contributions to improving global higher education. The honour also marks the upcoming 20th anniversary of the joint venture.

The Fellowship was conferred on 9 December during graduation ceremonies at Liverpool, where 2,500 graduates celebrated their achievements.

During his visit, Professor Xi met students on the flagship 2+2 programme, which enables learners to study at both XJTLU and the University of Liverpool. He toured the Liverpool School of Architecture’s new extension, and reunited with University of Liverpool colleagues who played an integral role in the establishment of XJTLU, including former Vice-Chancellor Professor Sir Drummond Bone, Professor Kelvin Everest, and Professor Michael Fang.

Professor Xi said: “Receiving this Honorary Fellowship is deeply meaningful to me, both personally and professionally. It represents the work we’ve done at XJTLU and symbolises the enduring partnership and shared vision between our two great institutions. 

“Seeing how our graduates are making their mark in the world with confidence and purpose fills me with pride. While in Liverpool, I was also able to reconnect with colleagues who stood with us at the very beginning of XJTLU’s journey.

Professor Youmin Xi (left) and Professor Tim Jones at the ceremony
Professor Youmin Xi (left) and Professor Tim Jones at the ceremony

“Celebrating XJTLU’s 20th anniversary is a moment to reflect on how far we’ve come and, more importantly, to look forward to where we’re heading. As we enter our third decade, I’m confident that XJTLU will continue to shape the future with wisdom and courage, staying true to our motto of ‘Light and Wings’.”

University of Liverpool Vice-Chancellor Professor Tim Jones said: “2026 marks 20 years since the foundation of Xi’an Jiaotong-Liverpool University. Under Professor Xi’s guidance, XJTLU has grown into an institution with a strong reputation for excellence in both education and research and, as we approach this milestone, we are delighted to recognise his achievements.

“Professor Xi exemplifies distinguished leadership, international distinction, and a strong commitment to the University of Liverpool’s mission and reputation. This honour reflects his pivotal role in building a globally respected institution that embodies the mission and ambitions of both universities.”

 

Under the Patronage of His Royal Highness the Crown Prince Governor of Riyadh Region Inaugurates MOMENTUM 2025 Development Finance Conference

RIYADH, Saudi Arabia, Dec. 10, 2025 /PRNewswire/ — Under the patronage of His Royal Highness Prince Mohammed bin Salman bin Abdulaziz Al Saud, Crown Prince, Prime Minister, and Chairman of the Board of Directors of the National Development Fund (NDF), His Royal Highness Prince Faisal bin Bandar bin Abdulaziz, Governor of the Riyadh Region, inaugurated today MOMENTUM 2025, hosted by the NDF under the theme “Where Development Finance Meets Action,” from 9 to 11 December 2025 at the King Abdulaziz International Conference Center.

His Excellency Mohammed bin Mazyad Al Tuwaijri stated that this generous patronage reflects the Kingdom’s leadership’s belief that investing in human capital is the most important investment to ensure a prosperous and sustainable future.

He highlighted the Kingdom’s leading role in reshaping the global development finance landscape, noting its alignment with the objectives of Vision 2030. He explained that the National Development Fund is presenting valuable insights during his participation with a distinguished group of speakers and experts from around the world, contributing to renewed momentum for development. He added that the NDF reaffirms its commitment, as outlined by the leadership, to strengthen collaborative efforts aimed at building a thriving society and enabling a more sustainable future.

His Excellency also said that since its establishment, the NDF has worked to stimulate financing and empower vital sectors through twelve development funds and banks that operate in close alignment to serve people, enhance the economy, and support environmental sustainability. He pointed out that the ecosystem provided financing exceeding SAR 52 billion in a single year and contributed approximately SAR 47 billion to non-oil GDP, demonstrating the transition from financing to development and from support to sustainable impact. It also served more than one million beneficiaries, raised development finance efficiency, enabled thousands of citizens to access financing and entrepreneurship opportunities, and launched high-profile projects that contributed to economic diversification and sustainable job creation.

The ceremony was also attended by a number of Royal Highnesses, ministers, CEOs, and international leaders and experts in the fields of development and economics.

MOMENTUM 2025 aims to support the strategic directives of the National Development Fund and its affiliated development funds and banks by enriching the development sector, enhancing ecosystem efficiency, strengthening capacity to meet national priorities, and improving coordination to ensure a unified and sustainable development impact on society and the economy.

Young Musicians Celebrate Lao Heritage at Khaen Contest 2025

On 6 December, Lao young musicians shined at the Khaen Contest 2025 in Vientiane, celebrating culture, music, and children’s right to play. (Photo credit: Thongsavanh Souvannasane)

Young musicians took center stage at the Children’s Khaen Contest 2025 in Vientiane on 6 December, demonstrating how traditional culture and early childhood development can work hand in hand.

Organized by the Ministry of Culture and Tourism, Sala Sujipuli, and the Namjai Community Association, the event was supported by UNICEF Lao PDR through its “Luem Ton Di” (Good Starts) initiative, powered by Vroom, and the Swiss Development Cooperation. 

Now in its third edition, the contest brought together children, families, teachers, and cultural leaders nearly 100 from across the country for a celebration of Lao heritage.

At the heart of the contest was the Khaen, Laos’ traditional bamboo mouth organ. UNESCO recognized the Khaen and its music as Intangible Cultural Heritage of Humanity in 2017, highlighting its role as a vital symbol of Lao identity and social cohesion. Children aged 7 to 18 performed on stage, building confidence while carrying this living tradition forward.

In his opening remarks, UNICEF Country Representative Bilal Aurang Zeb Durrani praised the young performers’ creativity and courage, thanking parents and teachers for championing learning through culture. He emphasized that play strengthens children’s brains, improves focus, teaches teamwork, and enables self-expression.

Bilal Aurang Zeb Durrani, UNICEF Country Representative to Lao PDR. Khaen Contest 2025 in Vientiane on 6 December . (Photo credit: Thongsavanh Souvannasane)

The event also showcased Luem Ton Di, a mobile app by UNICEF and the Lao Women’s Union that adapts the global Vroom tool for Lao families, offering science-based tips and WhatsApp guidance to turn everyday activities into brain-building opportunities for children, even in remote communities.

Cathay Petroleum Strengthens Global Expansion and Reaffirms Commitment to ESG Excellence

SINGAPORE, Dec. 10, 2025 /PRNewswire/ — Cathay Petroleum today announced their commitment and dedication to continuously upholding their ethical standards across their business activities and to be a better citizen of tomorrow. With regular assessments of their ESG outlook, the dedicated team at Cathay Petroleum is able to determine activities that can effectively improve livelihoods for those in need around the world.

By ensuring involvement with community-based and non-governmental organisations, Cathay Petroleum plays a part in the socio-economic progress of communities in need by working with children and youth to make valuable contributions to their well-being. Their partnerships with charitable organisations like HCSA Dayspring involved creating opportunities for social support of children and families in need in Singapore. They also supply humanitarian aid through donations to emergencies that occur worldwide, or in regions experiencing political and socio-economic strife. In global crises like COVID-19, Cathay Petroleum had responded by distributing N95 face masks and PPE materials to countries in the Middle East and Africa.

Cathay Petroleum is also able to act on ways to reduce their carbon footprint by understanding their impact on environmental risks. One example is that all chartered vessels in their resource management undergo a stringent vetting procedure to ensure environmental pollution is prevented. They also encourage employees to actively participate in environmentally-conscious behaviours and activities such as beach clean-ups and biodiversity projects to encourage them to develop a personal responsibility towards sustaining their physical environment.

For more information, visit: https://www.cathaypetroleum.com/

 

Bupa Hong Kong Broadens Network Across Hong Kong and Mainland China, Offering Access to Over 6,500 Hospitals and Service Points

“Bupa Green Concierge” will offer priority access to quality, affordable and personalised care in 300 Chinese cities and 3,600 hospitals


HONG KONG SAR – Media OutReach Newswire – 10 December 2025 – Bupa Hong Kong (“Bupa”) is proudly expanding its healthcare network to offer customers seamless, personalised and comprehensive care across Mainland China and Hong Kong. With access to more than 6,500 hospitals and service points, customers can enjoy cashless and priority medical services through Bupa’s extensive network.

Starting December 2025, selected Bupa customers will enjoy priority outpatient and hospitalisation booking services in Mainland China through “Bupa Green Concierge”, connecting them to more than 3,600 hospitals across 300 Chinese cities with the convenience of cashless access. The new service also includes access to network doctors providing specialised care, from preventive care and day procedure to cancer care support, ensuring a personalised and seamless care journey.

“The launch marks a significant expansion of Bupa’s healthcare network in Mainland China and Hong Kong, reinforcing our commitment to providing customers with accessible care wherever they need it most”, said Yuman Chan, General Manager of Bupa Hong Kong Insurance. “We are also proud to introduce ‘Bupa Green Concierge’ at a time when customers are seeking more robust options for medical care in Mainland China. By offering personalised support, an expanded network, and more affordable choices, while delivering on our ‘Connected Care’ strategy, we aim to help customers avoid long waits and receive timely, hassle-free care, ultimately improving health outcomes.”

The pioneering benefits of “Bupa Green Concierge” include:

  • Expanded Network – Coverage across 300 cities and 3,600 designated hospitals in Mainland China
  • Cashless Convenience – Access to medical services within Bupa’s hospital network
  • Priority Booking – Fast-tracked outpatient appointments at network hospitals within five working days
  • End-to-End Support – Assistance throughout the healthcare journey, including priority booking, registration, medication pickup and direct payment

In addition, Bupa customers can access to almost 3,000 service points in Hong Kong. “Bupa Care Managers” are now available at designated clinics to provide our members with personalised support, making their healthcare experience smoother and more centred around their needs. From assisting with digital health tools like Blua Health and ePharmacy, to offering guidance throughout clinic visits, to directing enquiries to the right Bupa teams—customers now get a healthcare experience which is smoother and more centred around their needs.

Meanwhile, Bupa Hong Kong was the first insurer to launch PharmaCare Programme with the city’s largest health and beauty chain Mannings: offering members cashless pharmacist consultation and medication at over 60 pharmacy locations across the city.

With the growing need for flexible, transparent and affordable healthcare options, our newly launched Blua Health Pass is a non-insurance, subscription-based product designed to make private outpatient care more accessible across Hong Kong. It offers health support at over 300 designated service points, tailored to different lifestyles and budgets. Open to both members and non-members, Blua Health Pass is ideal for freelancers, recent graduates, or anyone without outpatient benefits. This is a simple ‘buy and use’ solution, giving everyone convenient access to healthcare services.

For more information about “Bupa Green Concierge”, please visit www.bupa.com.hk/en/.

Hashtag: #Bupa #BupaHongKong #BupaGreenConcierge #BupaCareManager #BluaHealthPass #保柏 #保柏香港 #保柏綠色健康大使 #BluaHealth通行證

The issuer is solely responsible for the content of this announcement.

Bupa – A health insurance specialist

Established in 1947, Bupa’s purpose is helping people live longer, healthier, happier lives and making a better world. We are an international healthcare company serving over 60 million customers worldwide. With no shareholders, we reinvest profits into providing more and better healthcare for the benefit of current and future customers. Bupa has businesses around the world, principally in Australia, the UK, Spain, Poland, Chile, Hong Kong SAR, India, Türkiye, Brazil, Mexico and New Zealand. We also have associate businesses in Saudi Arabia.

Bupa (Asia) Limited, a subsidiary of Bupa, has been a health insurance specialist in Hong Kong since 1976, offering one-stop solutions across domestic and international health insurance, and healthcare services. Our comprehensive medical insurance schemes are tailored to meet individual needs, and we provide health solutions for companies of all sizes. We also have a team of registered nurses, health management professionals, and doctors who provide various expert healthcare support.

Our healthcare provision arm, Quality HealthCare Medical Services (QHMS), became part of Bupa Group in October 2013. QHMS offers Western Medicine, Traditional Chinese Medicine, Diagnostics & Imaging, Physiotherapy, Mental Health and Wellness services via a network of over 1,650 provider service points in Hong Kong.

For more information, visit .

Ascletis Announces China National Medical Products Administration Acceptance of New Drug Application for Denifanstat (ASC40), a First-in-Class FASN Inhibitor for Acne Treatment

-Denifanstat (ASC40) met all primary, key secondary and secondary efficacy endpoints (ITT analysis) and significantly improved moderate-to-severe acne vulgaris compared with placebo in a randomized, double-blind, placebo-controlled, multicenter Phase III clinical trial.

HONG KONG, Dec. 10, 2025 /PRNewswire/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces today that its New Drug Application (NDA) for denifanstat (ASC40), a first-in-class, once-daily oral small molecule fatty acid synthase (FASN) inhibitor for the treatment of moderate-to-severe acne vulgaris, has been accepted by the China National Medical Products Administration (NMPA).

“Acceptance of this NDA is an important milestone in our efforts to provide a potentially groundbreaking therapeutic approach for the treatment of moderate-to-severe acne,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, “We are excited denifanstat (ASC40) is only one step away from the commercialization.”

Ascletis has completed Phase II (NCT05104125) and Phase III (NCT06192264) studies of denifanstat (ASC40) for the treatment of moderate-to-severe acne vulgaris.

In the Phase III study, denifanstat (ASC40) met all primary, key secondary and secondary efficacy endpoints (ITT analysis) and significantly improved moderate-to-severe acne vulgaris compared with placebo. Denifanstat (ASC40) demonstrated a favorable safety and tolerability profile. All denifanstat (ASC40)-related treatment-emergent adverse events (TEAEs) were mild (Grade 1) or moderate (Grade 2). There were no denifanstat (ASC40)-related Grade 3 or 4 TEAEs and no denifanstat (ASC40)-related serious adverse events (SAEs). There were no denifanstat (ASC40)-related permanent treatment discontinuations or withdrawals observed.

The Phase III study results were presented as an oral presentation at the European Academy of Dermatology and Venereology (EADV) Congress 2025 in Paris, France on September 17, 2025 (link).

The Company recently completed the pre-NDA consultation with the China NMPA for denifanstat (ASC40) for the treatment of moderate-to-severe acne vulgaris and received positive feedback from NMPA.

Ascletis licensed denifanstat (ASC40) from Sagimet Biosciences Inc. (Nasdaq: SGMT) for exclusive rights in Greater China.

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a small molecule GLP-1R agonist designed to be administered once daily orally and once monthly to once quarterly subcutaneously as a treatment therapy and a maintenance therapy for chronic weight management; ASC36, a once-monthly subcutaneously administered amylin receptor peptide agonist, ASC35, a once-monthly subcutaneously administered GLP-1R/GIPR dual peptide agonist and ASC37, an oral GLP-1R/GIPR/GCGR triple peptide agonist for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

For more information, please visit www.ascletis.com.

Contact:

Peter Vozzo
ICR Healthcare
443-231-0505 (U.S.)
Peter.vozzo@icrhealthcare.com 

Ascletis Pharma Inc. PR and IR teams
+86-181-0650-9129 (China)
pr@ascletis.com
ir@ascletis.com