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International Day of Charity: Waterdrop Filter and The Water Project Mark 8-Year Milestone Bringing Clean Water to Kenya

NAIROBI, Kenya, Sept. 6, 2025 /PRNewswire/ — On the United Nations’ International Day of Charity, Waterdrop Filter joined The Water Project to celebrate eight years of partnership dedicated to expanding clean water access in western Kenya. Since 2017, the collaboration has delivered safe drinking water to thousands of children and families, evolving from individual project sponsorships to comprehensive program support that advances the UN Sustainable Development Goals.


How Has The Water Project Impacted their life

The partnership began in 2016 when Waterdrop Filter’s leadership learned of the severe lack of clean water in sub-Saharan Africa. Inspired by the belief that clean water is a basic human right, the company launched the Water4Smile initiative in 2017, pledging that every purifier sold would provide one day of clean water for a child. Choosing The Water Project as a trusted partner, Waterdrop Filter has built a collaboration that has grown stronger over eight years, reflecting its lasting commitment to global solidarity.

Early efforts included the construction of a rainwater catchment tank at Ematsuli Primary School, which directly benefited more than 825 students by providing reliable access to clean water. Over time, Waterdrop Filter shifted from sponsoring individual projects to providing program-level support that ensures broader and ongoing investment in public infrastructure and community services. This approach is helping to achieve the long-term goal of 100% clean water coverage across the regions served.

With Waterdrop Filter as a proud supporter, supporting a shared vision where 100% of people in the region have access to clean, safe water. Since its founding, the Water Project has completed more than 900,000 people in western Kenya have access to clean and reliable water thanks to over 2,600 facilities built and monitored with a 96% functionality rate.

At Kakoyi Primary School, a 13-year-old student named Angel explained how her life has changed: “The new water source will help our parents save their resources because we will not be suffering from waterborne diseases anymore. Teachers will also have more time with students because we no longer have to leave school to fetch water or miss class when seeking treatment.” Teacher Gilbert Sifuna added, “This water point will help restore hope among learners and teachers. It solves the challenges of water-related illnesses and the time wasted searching for water from distant, unreliable sources. It will also promote better hygiene practices and support improved academic performance.”

At Cheptuli Primary School, 14-year-old Margaret shared her story: “Previously, I had to carry water from home or walk long distances to find it, sometimes being denied by neighbors. It left me dirty and embarrassed in class. Now that we have a new water point, my hygiene will improve, and I will have enough time to focus on my studies.” Teacher Esther Shabaya noted, “In the past, I had to send students out of school to fetch water, which caused absenteeism and poor performance. With this new clean and reliable water source, water-related illnesses will be forgotten, and students can now focus fully on their education.”

“On this International Day of Charity, we are reminded that clean water is not only a basic human need, but also a foundation for dignity, education, and equality,” said Philip, the president of Waterdrop Filter. “Our eight-year journey with The Water Project proves that consistent charitable action can transform communities and create lasting change.”

About Waterdrop Filter

Founded in 2015, Waterdrop Filter is a leading brand in water purification, offering solutions for homes, offices, and outdoor use. Its product range includes under-sink and countertop Reverse Osmosis (RO) systems, pitchers, and whole-house filters. With the mission of making clean water accessible worldwide, Waterdrop Filter provides innovative water filtration solutions trusted by millions of households. The company remains committed to ESG practices, sustainable development, and empowering communities.

Learn more at www.waterdropfilter.com.

CONTACT: June Long, june@waterdropfilter.us 

Jackery to Present Full Essential Home Backup Series at RE+ 2025, Highlighting HomePower 3600 Plus

LAS VEGAS, Sept. 6, 2025 /PRNewswire/ — Jackery, a global leader in innovative solar generators and renewable energy solutions, will make a major splash at RE+ 2025, unveiling its new flagship  Jackery HomePower 3600 Plus alongside the full Essential Home Backup (EHB) lineup, next-gen balcony solar systems, and the Jackery Solar Roof. The showcase reinforces the company’s mission of delivering “sustainable power for your life” and underscores its long-term commitment to the U.S. market.

As extreme weather events become more frequent and grid reliability increasingly uncertain, the demand for practical and affordable backup power solutions is accelerating. RE+ 2025 offers Jackery a timely platform to showcase its EHB series, which is engineered to power core household essentials without the cost or complexity of whole-home systems.

Jackery takes part in RE+
Jackery takes part in RE+

Jackery’s EHB line ensures access to critical appliances like refrigerators, routers, and lights during outages. Unlike traditional systems with high installation costs and oversized capacity, Jackery focuses on flexibility, simplicity, and value. Portable and integrated options deliver automatic backup at up to half the cost of conventional setups.

The centerpiece of the lineup, Jackery HomePower 3600 Plus, will exhibit at RE+ 2025. Alongside the flagship, Jackery will also introduce additional models that expand the EHB category, such as the Jackery Explorer 5000 Plus, the Jackery Solar Generator HomePower 3000, and the Jackery Solar Generator 2000 Plus Kit.

In addition to backup systems, Jackery will also present the Jackery Solar Roof, a bold reimagining of residential solar design.

From compact portable generators to large-scale, expandable systems and integrated solar roofing, Jackery is aligning technological innovation with accessibility, affordability, and sustainability. This approach not only strengthens Jackery’s leadership in the U.S. household backup market but also highlights its broader role in advancing renewable energy adoption at a critical moment for the global energy transition.

To learn more about Jackery’s latest innovation, please visit its booth F17425 at Caesars Forum in Las Vegas, from September 9 to 11,2025.

For more information, please visit: https://www.jackery.com/ and connect via FacebookInstagramTwitterYouTube and TikTok.

CHiQ Showcases Panda-Themed AI Tech, FIS Sponsorship, and ESG Leadership at IFA 2025


BERLIN, GERMANY – Media OutReach Newswire – 5 September 2025 – The Internationale Funkausstellung (IFA), the world’s leading trade show for consumer electronics and home appliances, kicked off on September 5 in Berlin. At this year’s event, Changhong drew global attention with the debut of its panda-themed smart appliances, a strategic new partnership in winter sports, and a compelling demonstration of ESG initiatives, all underscoring the brand’s prowess in innovation and cultural storytelling.

Photo 1

Unveiled at IFA, Changhong’s panda-inspired product line artfully blends iconic cultural motifs with cutting-edge AI technology. The AI TV features an intelligent virtual companion, Panda Xiaobai, delivering round-the-clock interactive engagement and curated panda-themed content. The refrigerator uses AI-powered cloud humidity control to preserve freshness, while the air conditioner employs adaptive AI algorithms to fine-tune indoor climate with precision. Drawing from ink-wash aesthetics and panda silhouettes, the design reflects a graceful fusion of technological sophistication and natural elegance.

At the exhibition, CHiQ, Changhong’s international brand, announced a strategic three-year partnership with the International Ski Federation (FIS), becoming the official partner of the FIS Ski Jumping World Cup. Building on its existing involvement in German FIS events since 2023 and its collaboration with the German Ski Association (DSV), the agreement represents a significant step forward in CHiQ’s global sports marketing strategy. The brand also reaffirmed its alliance with ski jumping world champion Andreas Wellinger, jointly promoting the values of excellence and perseverance.

Photo 3

Furthering its commitment to inclusive sports, CHiQ became the official sponsor of the Wheelchair Tennis Open, hosted by the German Tennis Federation (DTB). At IFA 2025, DTB awarded CHiQ an honorary partnership certificate, recognizing its role in bridging technology and sport while advancing ESG values. This collaboration highlights CHiQ’s dedication to driving meaningful social impact through innovation and championing diversity, equality, and sustainability on a global scale.

In recognition of its achievements, CHiQ was honored with the “Leading AI Home Appliance Brand Award” at IFA 2025, celebrating its pioneering contributions to intelligent manufacturing and AI-driven innovation.

Photo 2

CHiQ’s strong presence at this year’s exhibition reflects a global strategy firmly rooted in technological innovation and cultural resonance. By integrating emblematic Chinese imagery and forging alliances with premier international sports platforms, the brand continues to elevate its premium positioning. Bolstered by its green technologies and AI-powered solutions, CHiQ has garnered widespread acclaim for its visionary approach. As Changhong’s flagship for international markets, CHiQ is poised to steadily earn consumer trust through relentless innovation and authentic value creation.

Hashtag: #CHiQ

The issuer is solely responsible for the content of this announcement.

TCL CSOT Set to Redefine Visual Experiences at IFA 2025 with APEX, Showcasing Breakthrough IJP OLED Displays

BERLIN, Sept. 5, 2025 /PRNewswire/ — TCL China Star Optoelectronics Technology (TCL CSOT), a global leader in display technologies, is set to unveil its groundbreaking display technologies at IFA 2025. Under its premium APEX display technology brand, the company will showcase its pioneering Inkjet Printing OLED (IJP OLED) technology and a curated product portfolio, demonstrating its commitment to creating sustainable, user-centric visual experiences that blend cutting-edge performance with environmental responsibility.

TCL CSOT showcases its latest display innovations at IFA 2025
TCL CSOT showcases its latest display innovations at IFA 2025

“Our presence at IFA 2025 is a testament to our vision for transforming visual technology,” said Jun Zhao, Chief Executive Officer of TCL CSOT. “We’re not just creating advanced displays – we’re developing solutions that enhance how people work, create, and connect while maintaining our dedication to sustainability and user well-being.”

Revolutionary Displays Reimagining User Experiences
The showcase features several industry-leading innovations designed to transform how users interact with visual content:

Advanced IJP OLED Series

  • 14-inch WU IJP OLED Notebook Display: Featuring 2K resolution and 99% DCI-P3 color coverage, this display delivers professional-grade color accuracy and enhanced pixel density, providing creators with true-to-life colors and sharp details for precision work.
  • World’s First 14-inch Oxide IJP OLED Notebook Display: Combining 2.8K resolution with over 1,000,000:1 contrast ratio, this innovation offers users vibrant visuals and extended battery life, making it ideal for mobile professionals who demand both performance and efficiency.
  • World’s First 16-inch 240Hz IJP OLED Notebook Display: With adaptive refresh rate (48-240Hz) and 400 nits brightness, this display provides gamers and content creators with smooth, blur-free visuals and excellent visibility in various lighting conditions, ensuring an immersive experience.
  • 27-inch 4K 120Hz IJP OLED Monitor Display: Offering professional color accuracy and seamless motion handling, this monitor meets the needs of creative professionals and entertainment enthusiasts alike, providing stunning 4K clarity and fluid visuals.

Pioneering Sustainable and Ultra-Slim Designs

  • 85-inch Ultra Low Power 8:9 Art TV Display: This revolutionary 85-inch display combines 4320×3840 ultra-high resolution with exceptional energy efficiency, consuming only 1 kWh over three days of typical use. The adaptive 10Hz refresh rate significantly reduces power consumption during static content display, while the specialized anti-reflection polarizer ensures museum-quality art presentation, making it perfect for both aesthetic appreciation and entertainment.
  • World’s Thinnest 14-inch a-Si LCD Notebook Module: At just 0.99mm thick and weighing only 99g, this breakthrough technology enables unprecedented portability and flexibility for mobile devices, allowing manufacturers to create lighter, more versatile products without compromising display quality.

Vision for the Future: Redefining Display Technology Leadership
TCL CSOT’s exhibition embodies the APEX brand philosophy of pushing display boundaries through continuous innovation. With over 65,000 global patent applications and industry leadership in display technology, the company maintains its position at the forefront of visual innovation through its 11 manufacturing lines and 7 manufacturing and R&D bases.

Looking ahead, TCL CSOT will continue to drive the display industry forward through its dual focus on technological excellence and environmental responsibility. The company remains committed to developing innovative solutions that balance stunning visual performance with sustainable design principles, shaping the future of how people experience and interact with digital content.

About TCL CSOT
Established in 2009, TCL China Star Optoelectronics Technology Co., Ltd. (TCL CSOT) is a leading global innovator in display technologies. Its LCD, OLED, and MLED solutions power applications across TVs, smartphones, tablets, laptops, monitors, automotive systems, VR/XR, and commercial displays. With a clear strategic direction set by its advanced display technology brand APEX, TCL CSOT invests continuously and strategically in R&D, driven by a mission to amaze, protect and inspire all people through endlessly innovative display technology. As part of TCL’s Worldwide Olympic Partnership, TCL CSOT is proud to deliver display solutions that elevate experiences on the global stage.

TCL CSOT showcases a suite of innovative IJP OLED Displays
TCL CSOT showcases a suite of innovative IJP OLED Displays

85-inch Ultra Low Power 8:9 Art TV Display
85-inch Ultra Low Power 8:9 Art TV Display

TECNO Wins Three Global Product Innovation Technology Awards at IFA 2025 for TECNO Slim, MEGABOOK S14, and AI Glasses Series

BERLIN, Sept. 5, 2025 /PRNewswire/ — TECNO,  a global AI-driven innovative technology brand, today celebrated a remarkable achievement at IFA 2025, one of the world’s largest and most influential consumer electronics trade fairs.  TECNO secured three prestigious IFA Global Product Technology Innovation Awards for its cutting-edge products: TECNO Slim, TECNO MEGABOOK S14, and TECNO AI Glasses Series, reinforcing its leadership in AI-driven innovation and next-generation consumer technology.

The IFA Global Product Technology Innovation Awards, co-hosted by IDG, IFA, and the German Chamber of Industry and Commerce (DIHK), are among the most authoritative honors in the global consumer electronics industry. Often regarded as a benchmark for technological innovation, these awards recognize pioneering products that set new industry standards, while also highlighting continuous advancements in AI-driven smart experiences and user-centric design.


This recognition underscores TECNO’s vision of making advanced technology accessible for users worldwide. Each awarded product represents a leap forward in design, intelligence, and user experience, reflecting the brand’s dedication to combining cutting-edge AI with sleek design. Through continuous innovation, TECNO strives to empower consumers across emerging markets and beyond, ensuring that technology inspires both creativity and connectivity.

TECNO Slim: World’s Slimmest 3D-Curved Smartphone

The TECNO Slim redefines smartphone engineering as the world’s slimmest 3D-curved phone with exceptional style, performance, and endurance. It comes in two variants: the SPARK Slim, the world’s slimmest curved-screen smartphone at just 5.93mm, and the POVA Slim 5G, the thinnest curved-screen 5G phone at only 5.95mm. Despite their sleek form, TECNO Slim integrates a long-lasting 5,160mAh high-density battery with 45W fast charging, a vibrant 144Hz 1.5K AMOLED screen protected by  Corning® Gorilla® Glass 7i, and military-grade shock resistance—proving that breathtaking slimness can coexist with uncompromising performance and rugged durability.

Beyond hardware, the TECNO Slim Series brings smarter experiences through TECNO’s AI-driven functions, including circle-to-search, AI writing, real-time translation, and advanced image intelligence. Its Mood Light Interactive Design on the camera module adds an expressive touch, subtly responding to user interactions. By balancing ultra-thin aesthetics with power, endurance, and intelligent features, the TECNO Slim Series sets a new benchmark for modern smartphones—delivering style without compromise.

TECNO MEGABOOK S14: Industry’s Lightest 14-inch OLED AI Laptop

At only 899g, the MEGABOOK S14 is the world’s lightest 14-inch OLED laptop. Available in two high-performance configurations—Snapdragon® X Elite Compute Platform and Intel® Core™ Ultra 9—the S14 introduces the world’s first self-developed on-device large language model on Windows, enabling advanced offline AI capabilities such as AI Meeting Assistant, Personal GPT, and AI-powered PPT generation. Its 2.8K OLED display with 120Hz refresh rate and DTS: X Ultra audio provides an immersive experience for creators, professionals, and gamers on the go.

TECNO AI Glasses: Futuristic AI-Powered Eyewear

TECNO’s AI Glasses set a new standard for smart wearables with the industry’s first 50MP ultra-clear imaging system integrated into eyewear. Powered by Ella AI Assistant, the glasses deliver real-time translation in over 100 languages, AI scene recognition, and AR navigation. The Pro model features a WaveGuide AR display that offers vivid MicroLED visuals and futuristic applications like live navigation and interactive AR. Crafted for comfort, the series combines lightweight durability with stylish frames for everyday use.

With these three awards, TECNO joins the ranks of global innovators that have shaped the future of technology through excellence and creativity. Staying true to its brand essence of “Stop At Nothing,” TECNO continues to break barriers by delivering powerful, stylish, and AI-driven intelligent solutions that resonate with consumers in global emerging markets and redefine the smartphone experience as a true global innovation leader.

About TECNO 
TECNO is an innovative, AI-driven technology brand with a presence in over 70 markets across five continents. Committed to transforming the digital experience in global emerging markets, TECNO relentlessly pursues the perfect integration of contemporary aesthetic design with the latest technologies and artificial intelligence. Today, TECNO offers a comprehensive ecosystem of AI-powered products, including smartphones, smart wearables, laptops, tablets, smart gaming devices, the HiOS operating system, and smart home products. Guided by its brand essence of “Stop At Nothing,” TECNO continues to pioneer the adoption of cutting-edge technologies and AI-driven experiences for forward-looking individuals, inspiring them to never stop pursuing their best selves and brightest futures. For more information, please visit TECNO’s official site: www.tecno-mobile.com.

Meet petgugu’s World’s First Self-Flushing Smart Cat Toilet at IFA: Redefining Hygiene and Health for Pet Families

BERLIN, Sept. 5, 2025 /PRNewswire/ — petgugu, a smart pet product brand that focuses on using AI and robotics technology to build data-driven intelligent pet care systems, proudly presents its Self-flushing Smart Cat Toilet at IFA 2025 in Berlin. As the world’s first cat toilet to instantly flush waste while turning each visit into a health insight, this launch reflects petgugu’s commitment to creating a nurturing and intelligent pet care ecosystem, offering multi-cat families more scientific and comfortable solutions. (petgugu Booth: 187, Hall 2.2).

World’s First Self-Flushing Smart Cat Toilet with Built-in AI Health Monitoring
World’s First Self-Flushing Smart Cat Toilet with Built-in AI Health Monitoring

True Hands-Free, Safe, and Hygienic

For decades, cat litter boxes have stored waste, creating odor, bacteria, and daily chores. In multi-cat households, the issue becomes even more challenging. The Self-flushing Smart Cat Toilet completely liberates cat owners with a patented flush-and-drain design that washes waste directly into the sewage line—leaving no storage, no odor, and no more scooping. The system also includes smart litter refill and immediate cleaning after each visit.

An 80L spacious cabin fits even large breeds, while the enclosed design provides privacy and comfort. Safety is ensured through multi-sensor protection—motion detection, infrared live sensing, and weight recognition—so cleaning only begins once cats have exited. Anti-trap Stop mechanisms prevent accidents if cats approach or re-enter, while kitten-and-senior modes protect lighter or less mobile pets.

For hygiene, the toilet combines negative-pressure airflow, activated-silicon filters, and UVC sterilization, with optional photocatalyst modules, to eliminate odor and bacteria at the source.

Intelligent Health Monitoring

Beyond hygiene, the Self-flushing Smart Cat Toilet functions as a health monitoring terminal. Each visit is logged with time, frequency, duration, and body weight, giving families a detailed view of their cats’ routines.

Through the petgugu App, these data points are transformed into daily, weekly, and monthly health reports, helping owners and veterinarians detect early signs of constipation, urinary blockage, or digestive issues. Real-time alerts notify families when anomalies appear, allowing intervention before problems escalate.

An integrated wide-angle camera records each toileting session in the local cloud. These videos provide an additional diagnostic reference—allowing pet parents to confirm changes such as softer stools, longer squatting times, or repeated attempts to urinate. Privacy is fully protected, with access restricted to authorized accounts only, while ensuring compliance with local regulations regarding online privacy and information security.

Together, these features transform the Self-flushing Smart Cat Toilet into a true health guardian—not just cleaning after cats, but proactively safeguarding their well-being.

Availability

The petgugu Self-flushing Smart Cat Toilet is now available for sale globally. For more information, please visit www.petgugu.com.

About petgugu

petgugu, founded in 2022 and headquartered in Singapore, operates a 50,000 m² R&D and production base. petgugu focuses on AI and robotics technologies to develop smart pet products. The company builds data-driven intelligent pet care systems covering toileting, feeding, drinking, cleaning, grooming, and companionship. petgugu is committed to providing families with more scientific, reassuring, and comfortable pet care solutions, so families can enjoy pure companionship and happiness.

Lefant Unveils M5 Robotic Vacuum at IFA 2025: Combining Compact Design with Instant Self-Cleaning Roller Mopping Technology

BERLIN, Sept. 5, 2025 /PRNewswire/ — Lefant, a global leader in home cleaning solutions, today unveiled its next-generation flagship robot vacuum and mop, the Lefant M5, at IFA 2025 in Berlin. The M5 combines advanced vacuuming with instant self-cleaning roller mopping in an impressive compact design, ideally suited for European households with limited space and complex layouts. (Lefant Booth: 187, Hall 2.2).

Compact Lefant M5 with Advanced Instant Self-Cleaning Roller Mopping
Compact Lefant M5 with Advanced Instant Self-Cleaning Roller Mopping

“Lefant does not simply seek to stack technical specifications. In Lefant, every innovation is aimed at enhancing daily cleaning experiences and making cutting-edge cleaning technology affordable for every family. With the M5, we take this philosophy to a flagship level,” said Dr. Sean Song, Vice President of Lefant.

Smaller Size, Bigger Coverage

The Lefant M210 series has sold millions of units across Europe, gaining household trust for its compact size and exceptional value. The M5 retains the M210’s advantages, featuring a 320 mm body—the smallest in its class—that maximizes coverage, navigates tight spaces, and provides more comprehensive cleaning for households.

Innovative Roller Live Water Mopping System

At the core of the M5 is Lefant’s Roller Live Water Mopping system, which enables robotic vacuums to match the cleaning power of professional floor washers. Unlike traditional flat mops that trap and spread dirt, the M5’s roller refreshes itself with circulating clean water, ensuring a hygienic cleaning surface on every roll. The roller’s unique line contact with the floor increases downward pressure and friction, significantly enhancing its ability to remove stubborn stains on hard surfaces.

Tangle-Free, Hassle-Free

Hair tangles are a major challenge in home cleaning, especially for pet families. The M5 solves this with a V-shaped main brush and an arc-shaped side brush, which centralize hair and dust toward the suction port, while featured dual-comb teeth prevent hair wrap and deliver optimal cleaning without manual intervention. Combined with 12,000 Pa suction power, the M5 effectively handles pet hair, dust, and everyday messes on multiple surfaces.

Advanced Navigation for Superior Obstacle Avoidance

The M5 is equipped with dToF laser navigation, 190° wide-angle PSD sensors, and Freemove™ technology for accurate mapping and obstacle avoidance. This advanced system allows the robot to move smoothly through cluttered environments with fewer collisions and missed areas.

Effortless Maintenance with All-in-One Base Station

The all-in-one base station enhances convenience with automatic dust collection, clean and dirty water tanks, roller washing, and room-temperature air drying. This streamlined system keeps the M5 clean and ready for the next cycle, reducing maintenance effort and ensuring consistent performance.

Availability

The Lefant M5 will be available for global purchase in the fourth quarter of 2025. For more information, visit our website: https://www.lefant.com/.

About Lefant

Lefant, a leading brand in home cleaning solutions, has shipped over 10 million robotic vacuums globally, with multiple models ranking among best sellers in global markets. With its compact design, ease of use, and exceptional value, Lefant aims to enhance daily cleaning experiences with every innovation and make cutting-edge cleaning technology affordable for every household.

Huadong Medicine Announces Positive Preliminary Results from a Phase Ⅰ study of HDM2005, a ROR1-Targeting ADC

HANGZHOU, China, Sept. 5, 2025 /PRNewswire/ — Huadong Medicine Co., Ltd. (hereinafter referred to as “Huadong Medicine“) today announced positive preliminary results from a Phase I study of HDM2005, an independently developed Class 1 innovative antibody–drug conjugate (ADC) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) or classical Hodgkin lymphoma (cHL). The results showed that HDM2005 demonstrated promising efficacy with a favorable safety and tolerability profile in B-NHL and cHL, which will support the clinical development moving forward.

ROR1 is a transmembrane protein overexpressed in various cancers, including lymphomas. HDM2005 is composed of a humanized IgG1 monoclonal antibody, a proteolytically cleavable linker, and the cytotoxic payload monomethyl auristatin E (MMAE). In preclinical studies, HDM2005 demonstrated potent anti-tumor activity across multiple lymphoma and solid tumor models. This first-in-human Phase I study (NCT06615193) enrolled patients with relapsed or refractory B-NHL or cHL. The primary objectives were to evaluate safety and tolerability, determine the maximum tolerated dose (MTD) and the recommended Phase Ⅱ doses (RP2Ds) and perform a preliminary evaluation of antitumor efficacy in lymphoma.

As of July 4, 2025, a total of 29 patients were enrolled (n=1, 4, 10, 11 and 3 in the 0.3, 1.0, 1.8. 2.5 and 2.75 mg/kg dose cohorts), including 17 patients with mantle cell lymphoma (MCL), 8 patients with diffuse large B-cell lymphoma (DLBCL), and 4 patients with cHL. Most patients (21, 72.4%) had received ≥3 prior lines of anti-tumor therapy. No patient permanently discontinued treatment due to treatment related adverse events (TRAEs). In the 1.8 mg/kg and 2.5 mg/kg cohorts, 38.1% of patients (8/21) experienced Grade ≥3 TRAEs, the most common (≥5%) being neutrophil count decrease (4 patients, 19.0%). No Grade ≥3 gastrointestinal adverse reactions or peripheral neuropathy were reported. Peripheral neuropathy occurred in 4 patients (13.8%), all of which were Grade 1 or 2.

In the 1.8 mg/kg and 2.5 mg/kg cohorts, the objective response rate (ORR) was 50% (6/12) in MCL patients, including 1 complete response (CR) and 5 partial responses (PR). The ORR was 100% (2/2) in cHL patients with CRs.

The preliminary results of this Phase I clinical trial show that HDM2005 was well-tolerated and demonstrated promising anti-tumor activity in patients with relapsed/refractory B-NHL or cHL. Huadong Medicine will commit to its “science-driven, patient-centered” mission, advance HDM2005 through clinical development and registration, and strive to bring more treatment options to patients.

About HDM2005

HDM2005 Injection is a Class 1 innovative biologic drug targeting ROR1. It is an ADC independently developed by Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., a wholly-owned subsidiary of Huadong Medicine, which holds global intellectual property rights. The clinical trials for HDM2005 were approved in June 2024 by the National Medical Products Administration (NMPA) and the U.S. Food and Drug Administration (FDA) respectively, for the treatment of advanced malignant tumors. In February 2025, HDM2005 received Orphan Drug Designation from the U.S. FDA for the treatment of mantle cell lymphoma (MCL). In April 2025, its Investigational New Drug (IND) application for use in combination with rituximab, cyclophosphamide, doxorubicin (or epirubicin), and prednisone (R-CHP) for previously untreated diffuse large B-cell lymphoma (DLBCL) was approved by the NMPA.

The project is currently advancing at the first tier of the global clinical R&D landscape for ROR1 ADC. The following 3 clinical trials are currently ongoing in China:

  • A Phase I trial of HDM2005 monotherapy for advanced hematologic malignancies (MCL, DLBCL, cHL): four dose-escalation cohorts have been completed, the fifth cohorts is ongoing, with expansion phases initiated at two dose levels.
  • A Phase I trial of HDM2005 monotherapy for advanced solid tumors: the first patient was dosed in May 2025, and the trial is currently in dose-escalation.
  • A Phase I b/Ⅱ trial of HDM2005 combination therapy for DLBCL patients: the leading site has been activated.