LOS ANGELES, Aug. 28, 2025 /PRNewswire/ — RingConn, known for cutting-edge smart rings, launches its Gen 2 Smart Ring on BestBuy.com, advancing its mission to expand access to advanced health technology in the U.S. The availability of RingConn Gen 2 on BestBuy.com, marks another major strategic step in expanding the brand’s presence in mainstream American retail following its collaboration with Target.com and Walmart.com.

Best Buy, the leading consumer electronics retailer in the United States, operates more than 1,000 stores nationwide and is renowned for curating innovative technology products that combine performance, convenience, and style. Wearables are one of Best Buy’s core categories, spanning smartwatches, fitness trackers, and smart rings. As an innovation leader in the smart ring sector, RingConn’s entry into Best Buy not only underscores its strengths in technology, market demand, and brand potential, but also signifies an important step in reaching more health-conscious consumers through this mainstream consumer electronics platform. By leveraging Best Buy’s brand influence and extensive retail network, RingConn will further expand its presence and channel footprint in the U.S. market.

With features such as sleep apnea monitoring, ultra-lightweight craftsmanship, and advanced AI integration, RingConn has already earned the trust of over 250,000 users worldwide. While actively expanding its global strategic markets, RingConn remains committed to continuous innovation and its mission of empowering healthier lifestyles, consistently rolling out software updates and functional enhancements. Looking ahead, RingConn will further strengthen its offerings with expanded sports mode support, women’s health features, and a more integrated AI-driven data experience. The U.S. has always been a key strategic market for RingConn, and this partnership with Best Buy will enable the brand to connect with a broader mainstream audience, enhance its influence, and bring RingConn’s vision of health technology into the daily lives of more consumers.

The RingConn Gen 2 Smart Ring, now available at BestBuy.com was launched in late 2024 and broke a Kickstarter category record with $4.4 million in crowdfunding. It’s the world’s first smart ring to offer sleep apnea monitoring. Besides, Gen 2 holds several technical distinctions:

• Lightest available model at 2-3 grams, and thinnest profile in its category at 2mm
• Extended battery life of 10-12 days
• Cross-platform compatibility (Android/iOS) with no subscription fees
• Advanced menstrual cycle monitoring feature

To ensure the best wearing experience, Best Buy customers can first order a sizing kit on the website, after a period of trial wear to confirm ideal smart ring size. This partnership with Best Buy marks a significant step for RingConn in expanding its presence in the mainstream consumer tech market, enabling the brand to reach more health-conscious users.

About RingConn

Established in 2021, RingConn is a leading personal health technology company dedicated to creating innovative products and services that transform the experience of maintaining personal wellness. Guided by the principle of “Hardware + Software + Services,” RingConn aims to provide unique products and services for people’s health.

MILAN, Aug. 27, 2025 /PRNewswire/ — DFSK has been named as the technical sponsor of the 2025 ICF Canoe Sprint and Paracanoe World Championships, where it provided critical mobility services for this prestigious international aquatic event. Sanctioned by the International Canoe Federation (ICF), the competition took place in Milan from 20-24 August, welcoming more than 800 athletes from almost 70 nations.

Reliable Excellence in Global Event Partnerships

Engineered under SERES Group’s rigorous quality standards and advanced new energy technology, four E5 models were deployed to ensure reliable transportation service. The E5 model boasts an exceptional driving experience, complemented by comfortable and flexible interior and a 76% customer recommendation rate, underscoring its reliability in supporting the smooth operation of this high-profile event.

Intelligent Mobility meets Athletic Precision and Endurance

In Canoe Sprint, success lies in the athletes’ precise route control, stable endurance, and coordinated bursts of power. The DFSK E5 also embodies the same qualities of precision, endurance and peak performance.

E5 adopts SERES Super Electric Hybrid System with 130kW peak motor power and 330N.m peak torque, delivering a quiet and smooth pure-electric drive. As a mid-size SUV, it is equipped with MacPherson front and multi-link independent rear suspension, enabling an agile maneuvering that is ideal for urban traffic and event logistics. E5 also boasts a combined range of up to 1000 km, a 17.5kWh battery, and an electric vehicle range of 87 km. With its high performance, flexibility and comfort, the E5 ensures efficient and reliable shuttle services throughout the championship.

From Competition to Daily Life: The Drive to Advance

DFSK, as a pioneer in smart electric mobility, upholds the philosophy of “Drives for better”, and is committed to making cutting-edge technology practical and accessible for diverse lifestyles. Similarly, the ICF Canoe Sprint Championship celebrates perseverance and global inclusivity, promoting sports and sustainability as forces for collective progress. On the water, athletes push boundaries with every stroke; Off the course, DFSK innovates to redefine mobility. United by a shared ethos of relentless advancement, both empower individuals to move forward with confidence, purpose, and zero compromise.

By sponsoring this premier event, DFSK demonstrates its dedication to green initiatives and inclusive excellence, delivering professional, efficient and reliable transportation while inspiring a sustainable future for all.

From Aug 27 through Sep 4, all Bestqool Products will be available at unbeatable prices.

NEW YORK, Aug. 27, 2025 /PRNewswire/ — After long hours of daily work, the body needs more than rest — it requires a sustainable, gentle, and easy-to-maintain recovery method. Bestqool, a health and wellness technology brand for light-based recovery, is celebrating this year’s Labor Day with an important message: Honor your labor by protecting the body that does the work.

For a limited time, Bestqool is offering 12% off all products from August 27th to September 4th, giving workers the opportunity to bring red light therapy home and make recovery a part of their daily routine.

The Health Challenges Facing Workers — A Lopsided House

Today’s labor force, whether it’s in an office or on a construction site, is exposed to constant and multiple muscle strains. From office cubicles to construction sites, today’s workers grapple with layers of stress. People working at desks all day commonly have stiff necks and shoulders, lower back pain, and strained eyes from prolonged sitting and screen time. Repeated movements and uncomfortable postures affect mainly the back, knees, wrists, and shoulders areas and put workers at risk of muscle and joint wear and tear over time.

Mental fatigue is equally widespread. High levels of mental strain have left office workers battling with headaches, lack of concentration, and disturbed sleep. Physically demanding jobs in loud, stressful conditions often drain physical and mental energy and reduce the ability to recover. These issues don’t just disappear with a mini vacation or work pause; instead, they mount up, turning into chronic issues that steadily damage health and quality of life.

The Shortcomings of Conventional Treatments

For decades workers rely on various traditional pain relieving drugs and rehabilitation methods. They are effective, but each has its drawbacks.

• Medications: Pain killers and anti-inflammatories can ease symptoms temporarily, but their long term usage carries risk for the digestive system, kidneys and cardiovascular health.
• Physical therapy: Rehabilitation methods are effective but challenging as these require fixed appointments and travel during work hours, and financial commitment.
• Surgery/Interventional Procedures: While sometimes necessary and effective, these pose a higher risk and longer periods of recovery that many workers cannot afford.
• Heat/Cold therapy or Passive Rest: Treats only superficial symptoms but rarely fixes stiffness, fatigue, or deep tissue issues.

The Advantages of Light-Based Therapy (Photobiomodulation)

Red and near-infrared light therapy, commonly referred to as “red light therapy” (RLT), has been proven as a safe, effective, and sustainable pathway to recovery for today’s workforce^[1][2][3]. In contrast to some other solutions that provide only temporary masking of symptoms, RLT works at the cellular level – supporting the body’s recovery ability.^[4]

This form of therapy relies on specific wavelengths of light, specifically red (660 nm) and near-infrared (850 nm). They can pass through the skin and subcutaneous tissues, promoting circulation, improving the delivery of oxygen to the tissues, and facilitating energy production in the mitochondria of the cells^[4]. By promoting better cellular function, RLT helps the body heal itself effectively.

For an office professional managing tension in the neck and shoulders, or a frontline worker hampered with aching knees and painful back, RLT provides a soft but mighty approach to building resilience and quality of life over time. As compared to traditional treatments, light-based therapies have three distinct advantages:

1. Budget saving: No periodic expensive treatments needed. Short daily sessions at home can help cut longer-term costs.
2. Fewer side effects: Since light treatment doesn’t use systemic drugs, it avoids the “rob Peter to pay Paul” problem of alleviating one issue while causing another.
3. Convenience and Adherence: Home or office light therapy devices can be integrated into daily schedules, allowing caregivers, shift workers, and professionals with demanding schedules to experience realistic recovery on a regular basis. Short, regular sessions can be completed in minutes and — when maintained over time — provide gentle, cumulative recovery after work.

Bestqool Products Recommendations For Workers

Bestqool devices are designed by keeping the needs of working people in mind — safe for frequent use, easy to operate, and beneficial for cumulative benefits. Three leading models will be highlighted in this year’s Labor Day event.

BQ60 — Compact, Portable Dual-Wavelength Device

Combines 660nm red light (skin health, collagen, superficial recovery) with 850nm near-infrared light (deep tissue, joints and muscle recovery).

• Small and lightweight, it comes with a foldable stand, making it convenient.
• Ideal for local treatments such as neck, joints and shoulders after daily wear and tear.

Key Benefit: Portable and affordable without sacrificing medical-grade irradiance.

Pro100 — Mid-Size, Four-Wavelength Device

Delivers a higher irradiance output and larger treatment area compared with the BQ60.

• Combines four-wavelength for a broader range of benefits such as anti-aging, skin rejuvenation, muscle performance and deeper tissues recovery.
• Designed for Modular Use: Can be connected with additional panels for expanded coverage.

Key Benefit: Efficient for workers who desire both beauty/wellness benefits (skin, hair, mood) and deeper musculoskeletal recovery

Pro300 — Full-Surface, Four-Wavelength Device

Larger surface area for comprehensive body treatment; 2 units can be combined together for full body treatment.

• It emits stronger power density meaning shorter therapy sessions are needed to achieve therapeutic effect.
• Includes optional splicing hardware for modular expansion and ceiling, or stand mounting options for workplace or gym.

Key benefit: Superior efficiency and coverage – perfect for physically demanding workers, athletes, or anyone managing chronic conditions.

A Labor Day Commitment to Worker Wellness 

Labor Day should not be just a holiday; it is a reminder that the working class is the backbone of our society. While workers strive for a better life, they must also protect the body that makes the life possible. Bestqool’s Labor Day sale isn’t just about a discount — it’s a tangible opportunity to add recovery into the regular routine.

Promotion Period: August 27th – September 4^th
Deal: 12% discount on all products of Bestqool
Available on both Bestqool official website and Amazon store

Schedule Caring for Yourself

For the millions of workers hustling their bodies for a chance at a better life, recovery should not be a luxury. Bestqool offers affordable, science-based tools to help people take care of themselves every day, building resilience not only for work, but for the moments that matter beyond it.

Bestqool hopes its easy-to-use, sustainable light-therapy devices will help make “recovery” an achievable daily habit. Prioritize self-care as part of your routine; small, regular investments in recovery compound into better work performance and higher quality of life.

Media contact

Name: Giselle
Email: marketing@bestqool.com

Reference list

1.Barolet, D., & Boucher, A. (2008). Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: A case series. Lasers in Surgery and Medicine, 40(7), 441–450. https://doi.org/10.1002/lsm.20646

2. Gupta, A., Avci, P., Sadasivam, M., Chandran, R., Parizotto, N. A., Vecchio, D., … & Hamblin, M. R. (2013). Shining light on the head: Photobiomodulation for brain disorders. Lasers in Surgery and Medicine, 45(7), 515–532. https://doi.org/10.1002/lsm.22190

3. Hamblin, M. R. (2017). Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophysics, 4(3), 337–361. https://doi.org/10.3934/biophy.2017.3.337

4. Huang, Y. Y., Chen, A. C., Carroll, J. D., & Hamblin, M. R. (2009). Biphasic dose response in low level light therapy. Dose-Response, 7(4), 358–383. https://doi.org/10.2203/dose-response.09-027.Hamblin

5. Schiffer, F., Johnston, A. L., Ravichandran, C., Polcari, A., Teicher, M. H., Webb, R. H., & Hamblin, M. R. (2009). Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: A pilot study of 10 patients with major depression and anxiety. Behavioral and Brain Functions, 5(1), 46. https://doi.org/10.1186/1744-9081-5-46

HONG KONG, Aug. 27, 2025 /PRNewswire/ — Fangzhou Inc. (“Fangzhou” or the “Company”) (06086.HK), a leader in AI-driven Internet healthcare solutions, reported a profitable first half of 2025, supported by an expanding user base, higher operating efficiency, and accelerated deployment of AI across its healthcare services and internal operations.

Net Profit Swings to Positive as Targeted User Base Unlocks Growth

Fangzhou posted revenue of RMB 1.494 billion for the six months ended June 30, up 12.9% from a year earlier. Net profit reached RMB 12.5 million, compared with a loss of RMB 818.7 million in the same period last year. Adjusted net profit also increased 16.8% to RMB 17.6 million, marking a new high.

Registered users on the platform grew 15.8% year-on-year to 52.8 million, while monthly active users surged 34.4% to 11.9 million. Registered doctors increased to 229,000. Paid user repurchase rate rose to 85.4%, underscoring high user stickiness.

Revenue from online retail pharmacy services climbed 28.2% to RMB 864 million, while medical services revenue rose 11.4% to RMB 357 million. By mid-2025, the company’s drug catalog reached 215,000 SKUs, with prescription medicines accounting for about 62%. Fangzhou has built supply chain partnerships with over 1,650 suppliers and more than 980 pharmaceutical firms.

During the period, the Company launched a number of innovative drugs through its platform from leading pharmaceutical companies including Novo Nordisk, Otsuka Pharmaceutical, Novartis AG, and Takeda Pharmaceuticals.

Dr. Xie Fangmin, founder, chairman, and CEO of Fangzhou, commented: “Our strong half-year results reflect both the resilience of our business model and the accelerating value of implementing AI in chronic disease management. By upgrading the full patient journey and deepening collaboration with global and local partners, we are well positioned to deliver sustained growth while contributing to the ‘Healthy China 2030’ goals.”

Enhanced Health Management Driven by AI

The Company has accelerated the rollout of AI across user services, procurement, marketing and content production in 1H 2025.

Fangzhou’s upgraded “AI+H2H” platform integrates advanced large-model capabilities to support both immediate health consultations and long-term disease management. The Company’s AI pre-diagnosis agent now provides 24/7 online support to doctors, helping them compile patient symptoms and medical history data, while AI customer service tools guide patients through medication use to improve adherence and lower operating costs.

Internally, Fangzhou deployed AI procurement and content creation assistants, along with predictive models for marketing efficacy in order to reduce spending and boost efficiency.

Fangzhou is also expanding its integration with China’s national medical insurance system. After introducing online follow-up consultation and prescription services for insured patients last year, the Company continued to improve connectivity and service capabilities in the first half of 2025, laying the groundwork for broader regional expansion.

Looking into the future, Fangzhou plans to pursue a “technology innovation + digital integration” strategy, embedding AI more deeply into its business operations and expanding applications of “AI + chronic disease management.” It will also step up collaboration with global and domestic drugmakers, health institutions and insurers to build a diversified digital healthcare ecosystem, aiming to drive industry momentum and support China’s broader goals for a stronger national health system and high-quality development in Internet healthcare.

About Fangzhou Inc.

Fangzhou Inc. (06086.HK) is China’s leading online chronic disease management platform, serving 52.8 million registered users and 229,000 physicians (as of June 30, 2025). The Company specializes in delivering tailored medical care and precision medicine solutions. For more information, visit https://investors.jianke.com.

Media Contact
For further inquiries or interviews, please reach out to:
Xingwei Zhao Associate Director of Public Relations Email: pr@jianke.com

Disclaimer: This press release contains forward-looking statements. Actual results may differ materially from those anticipated due to various factors. Readers are cautioned not to place undue reliance on these statements

– Bali, Indonesia provided the backdrop for a 15-day cultural collaboration, bringing together 48 university students from 17 countries to create food-themed films

– Premiere on the 24th at Asia‘s largest club drew an international crowd

– Daesang K-Food Week provided 7,000 visitors with K-Food platters and premiere invitations

SEOUL, South Korea, Aug. 27, 2025 /PRNewswire/ — Daesang Group announced on the 27th that the 5th DAESANG E.T.F.F. (Eat & Travel Film Festival), a global university student smartphone film festival, concluded successfully in Bali, Indonesia with enthusiastic participation from future global talents.

Now in its fifth year, DAESANG E.T.F.F. is a global cultural exchange program rooted in Daesang Group’s core value of Respect. It brings together students from diverse national and cultural backgrounds to travel, collaborate, and create short films on the theme of Food. This year, the festival offered an evolved brand experience, allowing global tourists in Bali to enjoy a screening while tasting Daesang Group’s popular K-Food items such as tteokbokki, fried chicken, gimbap, and dumplings.

The festival expanded its scope to a global level, selecting 48 students from 17 countries, including Korea, Indonesia, Vietnam, Iran, Cambodia, India, the United States, and Russia, through a highly competitive competition. Working in eight teams of six, the students collaborated on scriptwriting, filming, editing, and promotion of their five-minute films, all created using smartphones, from August 11 to 25.

The completed works, showcasing collaboration and creativity, were unveiled on the 24th at a screening held at Atlas Super Club, Asia’s largest club, before a global audience. Winners were selected by a panel of judges, including Director Lee Do-yoon, known for the Netflix series Trauma Center, and Professor Park Ji-hoon of Seoul Institute of the Arts, with audience members also voting for their favorites.

This year’s festival also introduced Daesang K-Food Week in the week leading up to the awards ceremony, further building excitement. In collaboration with eight popular local restaurants in Bali, Daesang offered visitors a Daesang K-Food Platter featuring dishes such as tteokbokki, gim bugak, kimchi jeon, and kimchi spread, alongside invitations to the film screening. Additional OOH advertisements at Bali’s Kuta Beach and major shopping malls amplified awareness and anticipation.

On the day of the premiere, the venue was packed with global tourists who enjoyed a wide range of K-Food from Daesang’s global brand O’Food, including tteokbokki, japchae, gimbap, and chicken, while watching the films. The first 300 attendees also received special K-Food packages designed for convenient consumption while traveling. One tourist remarked, “It was a unique experience to watch films created by students from around the world. Enjoying movies and food together felt like a true festival, and I was especially impressed by the harmony of flavors in the gimbap.”

Awards were presented in five categories: Grand Prize, Best Film, Best Promotion, Best Actor, and Best Participation. The Grand Prize went to Team Balicious (led by Hyunmin Kim and five others) for their film Coconut Allergy Club, earning a prize of KRW 10 million. Director Lee Do-yoon praised the work, stating, “It was a refreshing attempt that humorously broke down fears and prejudices through the theme of allergies. The sophisticated editing and natural performances resulted in a highly accomplished piece.” Team leader Hyunmin Kim (Chung-Ang University) commented, “We wanted to satirize a world where baseless hatred and prejudice spread like entertainment, using food and allergies as our motif.”

The award-winning films and behind-the-scenes videos are now available on the official DAESANG Eat & Travel Film Festival YouTube channel.

Choi Sung-soo, CEO of Daesang Holdings, stated, “This year’s festival evolved from being a cultural exchange program for students, rooted in the value of Respect, into a true global festival where people of diverse nationalities could enjoy both food and culture together. Through DAESANG E.T.F.F., we aim to provide even more students with the opportunity to travel the world with Daesang and grow into global leaders.”

Since entering the global market in 1973 with Korea’s first overseas plant export to Indonesia, Daesang Group has built a robust network in the food and ingredient industries, spanning Vietnam, Japan, China, the Philippines, Thailand, Myanmar, the U.S., Europe, Australia, and beyond. Today, Daesang continues to solidify its position as a leading global K-Food company.

About Daesang Corporation 

Founded in 1956, Daesang Corporation has been one of the world’s largest producers of fermented food products for over 60 years, and has grown to be the global leading Korean based food company by operating global brands such as Jongga, and O’Food which provides sauce, ready-to-eat meals, and many more products. Headquartered in South Korea, the company has also manufacturing subsidiaries in United States, Poland, China, Indonesia, and Vietnam. Visit www.daesang.com/en for more information. 

CAMBRIDGE, Mass., ROTTERDAM, Netherlands and SHANGHAI, Aug. 27, 2025 /PRNewswire/ — Harbour BioMed (“HBM” or the “Company”; HKEX: 02142), a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics in immunology and oncology, today announced its interim results for the six months ended June 30, 2025.

Dr. Jingsong Wang, Founder, Chairman, and CEO of Harbour BioMed, commented: “In the first half of 2025, Harbour BioMed achieved several significant milestones. During the reporting period, the company’s profit grew more than fiftyfold year over year, demonstrating strong growth momentum. Out-licensing and collaborations based on our innovative products have contributed significantly to revenue growth and have become a recurring source of income.

These results underscore the sustainability of our ability to translate innovation into commercial value and reflect the success of our diversified business model, which includes strategic partnerships, licensing collaborations, platform collaborations, and innovation incubation. Leveraging our industry-leading Harbour Mice^® platform and its extended 2.0 technology platform, Harbour BioMed has built a strong global collaboration ecosystem, positioning the Company as a cornerstone of global antibody drug development.

Looking ahead, we will continue to focus on innovation and accelerate the development of next-generation biologics to deliver better treatment options for patients worldwide.”

As of June 30, 2025, Harbour BioMed reported total revenue of approximately US$101.3 million for the first half of the year, representing a 327% increase year over year. Net profit reached approximately US$73.0 million, a 51-fold increase compared with the same period in 2024. The Company also reported a strong cash position of about US$320 million, a 92% increase since the end of the previous year.

During the reporting period, the company delivered strong performance, highlighting the success of its business model and solid financial position.

Advancing a Robust and Differentiated Pipeline

Harbour Therapeutics, a sub-brand parallel to Nona Biosciences, is now individually responsible for the development of the Company’s products pipeline on immunology and oncology. Harbour Therapeutics has established a rich and differentiated pipeline and continues to expand collaborations with leading global pharmaceutical companies and academic institutions to efficiently advance its programs. During the reporting period, several key clinical-stage projects achieved significant progress, alongside continued advancement of a robust portfolio of next-generation therapies.

Key products in the clinical stage include:

Batoclimab (HBM9161) is the first anti-FcRn monoclonal antibody completed Phase I to pivotal trials in China. As a novel, fully human anti-FcRn monoclonal antibody, batoclimab has the potential to be a breakthrough treatment option for a wide range of autoimmune diseases. In December 2023, the Company voluntarily planned to include additional long-term safety data and re-submitted the Biologic License Application (BLA) for batoclimab to the National Medical Products Administration of China (NMPA) in June 2024. In July 2024, NMPA accepted the BLA for batoclimab for the treatment of gMG. The Phase III pivotal clinical trial results of batoclimab were published in JAMA Neurology in March 2024, demonstrating sustained efficacy and safety with long-term use of batoclimab in the treatment of gMG.

HBM9378 is a fully human monoclonal antibody against thymic stromal lymphopoietin (TSLP) generated from the H2L2 Harbour Mice^® platform. It binds to the TSLP ligand and inhibits the TSLP mediated signaling pathway by blocking the interaction between TSLP and TSLP receptor. TSLP is a well-validated cytokine that plays a key role in the development and progression of a wide array of immunological conditions, including asthma and chronic obstructive pulmonary disease (COPD), where its inhibition has demonstrated benefit in a wide array of inflammatory phenotypes. HBM9378 has been engineered to achieve an extended half-life and effector silencing and is subcutaneously administered.

• The Company received IND approval of HBM9378 for moderate-to-severe asthma from the NMPA in February 2022 and completed a Phase I clinical trial in healthy subjects in China. In November 2024, the Company submitted an IND application for HBM9378 for COPD to the NMPA, which was approved in January 2025.
• In January 2025, the Company and Kelun-Biotech entered into an exclusive license agreement with Windward Bio, under which Windward Bio was granted an exclusive license for the research, development, manufacturing and commercialization of HBM9378 globally (excluding Greater China and several Southeast and West Asian countries). In July 2025, Windward Bio initiated the global phase 2 POLARIS trial to evaluate the dosing, safety, and efficacy of HBM9378/WIN378 in patients with asthma. Initial data are expected in mid-2026.

Porustobart (HBM4003) is a next-generation, fully human heavy-chain-only anti-CTLA-4 antibody discovered and developed using the HCAb Harbour Mice^® platform. It is also the first fully human heavy-chain-only antibody which entered clinical development globally. Compared with conventional CTLA-4 antibodies, porustobart has unique, favourable properties, including significant Treg cell depletion and optimized pharmacokinetics for improved safety. Additionally, by enhancing antibody-dependent cellular cytotoxicity (ADCC), porustobart increases the potential to selectively deplete intratumoral Treg cells, helping to overcome the efficacy and toxicity bottleneck of current CTLA-4 therapies. The Company has implemented a global development plan for multiple types of solid tumors with an adaptive treatment design for porustobart. Positive efficacy and safety data have been observed in the monotherapy trial targeting advanced solid tumors, as well as in combination trials with PD-1 inhibitors for melanoma, CRC, NEN and HCC. Final data from the study of HBM4003 in combination with toripalimab for advanced HCC were published in Clinical Cancer Research in August 2025. Data from the Phase II study of HBM4003 in combination with tislelizumab for the treatment of microsatellite stable (MSS) metastatic colorectal cancer will be presented at the ESMO Congress 2025.

HBM1020 is a first-in-class fully human monoclonal antibody generated from the H2L2 Harbour Mice^® platform targeting B7H7. As a newly discovered member of the B7 family, B7H7 expression is found to be non-overlapping with PD-L1 expression in multiple tumor types, potentially playing a more significant role in tumor immune evasion. With its excellent product design and target features, HBM1020 presents great potential to address significant unmet medical needs for solid tumors. In September 2024, the Company presented the latest clinical data for patients with advanced solid tumors at the ESMO Congress 2024. The data demonstrated excellent safety and tolerability profiles for HBM1020. Of the 15 patients who received post-treatment tumor assessments, 7 patients (46.7%) achieved stable disease (SD), with two patients showing tumor shrinkage of 11% and 25%.

Key products in the next-generation innovation portfolio include:

HBM7004 is a novel B7H4xCD3 bispecific antibody. Using HBICE^® bispecific technology and Harbour Mice^® platform, this bispecific antibody was designed to provide innovative solutions for cancer immunotherapy from both efficacy and safety perspectives. The development of B7H4xCD3 bispecific HBICE^® further consolidates the Company’s bispecific immune cell engager platform, demonstrating the HBICE^® platform’s versatility and plug-and-play advantages. In preclinical studies, HBM7004 demonstrated an intratumor B7H4-dependent T cell activation manner. In multiple animal models, HBM7004 showed strong anti-tumor efficacy, remarkable in vivo stability, and reduced systemic toxicity. Additionally, in preclinical models, HBM7004 exhibited a strong synergistic effect when combined with a B7H4x4-1BB bispecific antibody at a low effector-to-target cell ratio, indicating an encouraging therapeutic window. The Company is currently conducting IND-enabling studies for HBM7004.

HBM7020 is a BCMAxCD3 bispecific antibody generated using the fully human HBICE^® bispecific technology and Harbour Mice^® platform. HBM7020 can crosslink targeted cells and T cells by binding to BCMA and CD3 on the cell surface, leading to potent T cell activation and cell elimination. By incorporating dual anti-BCMA binding sites for optimal cell targeting and monovalent-optimized CD3 activity to minimize CRS, HBM7020 demonstrated potent cytotoxicity with broad applications in both immunological and oncology diseases. In August 2023, HBM7020 obtained IND clearance from the NMPA to commence a Phase I trial for cancer in China. In 2024, the Company restructured its development strategy to target immunological diseases. In June 2025, Harbour BioMed entered global strategic collaboration with Otsuka. Under the terms of the agreement, Otsuka is granted an exclusive license to develop, manufacture, and commercialize HBM7020 globally, excluding Greater China (Mainland China, Hong Kong, Macau and Taiwan).

R2006 (CD19xCD3 bispecific antibody) and HBM7026 (BCMAxCD19xCD3 trispecific antibody) are two T-cell engagers (TCEs) in preclinical development. TCEs have emerged as an important therapeutic strategy for autoimmune diseases, as B-cell depletion has been shown to help restore immune system balance in multiple autoimmune conditions. TCEs can achieve deep depletion of B cells in peripheral blood, lymph nodes, and bone marrow, thereby resetting the immune system. Newly generated B cells subsequently return to a naïve and non-pathogenic state, potentially reducing inflammation and autoimmune responses. CD19 is a marker broadly expressed on precursor and mature B cells, while BCMA is highly expressed on mature B cells and plasma cells. Leveraging its fully human HCAb technology and optimized anti-CD3 antibodies, Harbour BioMed is developing TCEs with enhanced safety, reduced immunogenicity, and lower risk of cytokine release syndrome.

In March 2025, Harbour BioMed launched Élancé Therapeutics (“Élancé”). Harnessing Harbour BioMed’s proprietary HCAb-based bispecific antibody technology, Élancé aims to develop innovative therapies addressing key challenges in current obesity treatment, including muscle preservation and long-term efficacy. Élancé is building a metabolic disease pipeline of multiple preclinical bispecific antibody programs. By integrating dual-targeting strategies with enhanced safety profiles, these therapies have the potential to complement and expand upon existing treatment options, including various agonists of GLP-1 receptor, GIP receptor, and GCG receptor and further expand the boundaries of obesity treatment.

Harbour BioMed is leveraging its fully human antibody and HCAb platforms to develop next-generation biologics for central nervous system (CNS) disorders, including bispecific antibodies and other “Antibody-Plus (Ab+)” therapies. The pipeline in this area is currently under development, with the goal of creating more complex molecules to address the treatment challenges of CNS disorders, including neurodegenerative diseases and neuroinflammation.

Maximizing Platform Potential Through Diversified Collaborations

Harbour BioMed remains committed to global collaboration. In March 2025, the Company entered into a global strategic collaboration with AstraZeneca to discover and develop next-generation multi-specific antibodies for immunology, oncology and beyond. The strategic collaboration includes an option to license multiple programs utilizing Harbour BioMed’s proprietary Harbour Mice^® fully human antibody technology platform in multiple therapeutic areas. Furthermore, AstraZeneca acquired 9.15% newly issued shares of Harbour BioMed with a $105 million equity investment. Harbour BioMed will establish an innovation center in Beijing, China to be co-located with AstraZeneca.

During the reporting period, Harbour BioMed also signed several licensing and collaboration agreements with global partners. In January 2025, the Company and Kelun-Biotech entered into a licensing agreement with Windward Bio for HBM9378/SKB378 (also known as WIN378), granting Windward Bio to research, develop, manufacture, and commercialize HBM9378/SKB378 globally, excluding Greater China and several Southeast and West Asian countries. In June 2025, Harbour BioMed entered a global strategic collaboration with Otsuka Pharmaceutical to advance the development of HBM7020, a BCMA x CD3 bispecific T-cell engager for the treatment of autoimmune diseases.

In February 2025, Harbour BioMed entered into a strategic collaboration with Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, to accelerate the discovery of novel therapeutic antibodies by combining complementary strengths in antibody discovery and artificial intelligence.

Leveraging its technological advantages, Harbour BioMed established Nona Biosciences to better empower industry innovators and support collaborators by providing integrated solutions from “Idea to IND” (I to I^TM). As a global biotechnology company, Nona Biosciences has established innovative platforms in antibody discovery, protein engineering, antibody-drug conjugation, HCAb-CAR screening, and drug delivery technologies, to accelerate the development of next-generation therapies across academic institutions, leading biotech companies, and multinational pharmaceutical companies.

In December 2024, Nona Biosciences entered into a collaboration with Kodiak Sciences (Nasdaq: KOD). This partnership aims to advance the discovery of novel multi-target antibodies to treat ophthalmic diseases, leveraging Nona’s proprietary Harbour Mice^® fully human antibody platform. In the same month, Nona Biosciences announced a research collaboration and license agreement with Candid Therapeutics to discover next-generation TCEs. In the first half of 2025, Nona Biosciences further expanded its global partnerships, entering into collaborations with Invetx, the University of Alabama at Birmingham, Atossa Therapeutics, and Visterra, unlocking the potential of its proprietary platforms to support partners in advancing biotherapeutics pipeline development and related research.

In addition, Nona Biosciences continues to expand the capabilities of its technology platforms. In March 2025, Nona Biosciences launched Hu-mAtrIx™, an innovative AI-assisted drug discovery engine integrates seamlessly with the company’s proprietary Harbour Mice^® technology platform, aiming to accelerate antibody discovery across multiple key therapeutic areas, including neurodegenerative and metabolic diseases, and more.

These collaborations further highlight the Company’s unique strengths in advancing innovation. Building on its industry-leading technology platforms and flexible business model, the Company will continue to expand capabilities, strengthen partnerships, and maximize platform value.

Incubating Breakthrough Therapies for the Future

Harbour BioMed continues to explore the scalability of its platform applications to fully unlock their potential. The Company is incubating several joint ventures focused on next-generation therapies, including multivalence antibodies, cell therapies, and more. By expanding the application scope of its platform technologies, Harbour BioMed aims to create additional value and accelerate next-generation innovation.

• In November 2024 and July 2025, NK Cell-Tech (an incubated company of Harbour BioMed) announced the completion of its Series A++ and Series A+++ financing rounds, respectively, to further advance its pipeline development and clinical progress.
• In February 2025, HBM Alpha Therapeutics, a joint venture between Harbour BioMed and Boston Children’s Hospital (an affiliate of Harvard Medical School), announced a strategic collaboration and license agreement with a business partner.
• In March 2025, Harbour BioMed launched Élancé Therapeutics, a new venture leveraging the Company’s proprietary HCAb-based bispecific antibody technology to develop innovative therapies addressing key challenges in current obesity treatment, including muscle preservation and long-term efficacy. In addition, Élancé will refine and expand Nona Biosciences’ Hu-mAtrIx^TM AI platform to support bispecific antibody discovery, with AI applications guiding antibody sequence discovery, enrichment, optimization, bispecific geometry design, and developability/immunogenicity/pharmacokinetics (PK) assessments, as well as patient biomarker studies.

Prospects and Outlook: Innovation and Collaboration

The achievements and growth momentum Harbour BioMed demonstrated in the first half of 2025 give us strong confidence in the future. Harbour BioMed has proven its ability to successfully navigate a complex market environment and is well-positioned to deliver innovative therapies for patients with immunology and oncology diseases in the near future.

Since its establishment, Harbour BioMed has been committed to developing innovative therapies for patients worldwide and has grown into an innovative biopharmaceutical company distinguished by its proprietary technologies and differentiated pipeline. In 2024, the Company successfully completed the BLA submission for HBM9161. Harbour BioMed will further accelerate the advancement of its portfolio, progressing multiple clinical trials for innovative programs which target both novel and established pathways, including HBM4003, HBM9378, and HBM1020. In addition, Harbour BioMed is expanding the capabilities of its platforms into immunology and inflammation, leveraging its powerful Harbour Mice^® and HBICE^® drug discovery engines to continue identifying novel high-quality candidates.

The value of Nona Biosciences’ antibody discovery platform and flexible collaboration model has been fully validated through a series of partnerships since its establishment in 2022. Building on this foundation, Harbour BioMed continues to strengthen global collaborations, offering one-stop solutions to academic institutions, biotech startups, and multinational pharmaceutical companies, and unlocking the full potential of its platforms through business partnerships. Looking ahead, Harbour BioMed will continue to advance its globalization strategy. As its preclinical products mature, the company expects to welcome more global collaboration opportunities in 2025.

Accordingly, Harbour BioMed will further optimize internal resource allocation, focus on advancing self-developed assets from its proprietary platforms, and continue expanding Nona Biosciences’ collaboration network—injecting fresh momentum into the Company’s long-term sustainable growth.

About Harbour BioMed

Harbour BioMed (HKEX: 02142) is a global biopharmaceutical company committed to the discovery and development of novel antibody therapeutics in immunology and oncology. The company is building a robust and differentiated pipeline through internal R&D capabilities, strategic global collaborations in co-discovery and co-development, and selective acquisitions.

Harbour BioMed’s proprietary antibody technology platform, Harbour Mice^®, generates fully human monoclonal antibodies in both the conventional two heavy and two light chain (H2L2) format and the heavy chain-only (HCAb) format. Building upon HCAb antibodies, the HCAb-based immune cell engagers (HBICE^®) bispecific antibody technology enables tumor-killing effects that traditional combination therapies cannot achieve. Additionally, the HCAb-based bispecific immune cell antagonist (HBICA^TM) technology empowers the development of innovative biologics for immunological and inflammatory diseases. By integrating Harbour Mice^®, HBICE^®, and HBICA^TM with a single B-cell cloning platform, Harbour BioMed has built a highly efficient and distinctive antibody discovery engine for developing next-generation therapeutic antibodies. For more information, please visit www.harbourbiomed.com.

NANTONG, China, Aug. 27, 2025 /PRNewswire/ — Sigenergy today announced the topping-out of its smart manufacturing hub in Nantong, Jiangsu, China, marking a major milestone in the company’s global manufacturing expansion. Following the groundbreaking earlier this year, the project has reached another key stage toward production, bringing the facility closer to operational readiness.

As one of Sigenergy’s core production bases, the Nantong Smart Manufacturing Hub plays a pivotal role in the company’s globalization strategy. It will support large-scale delivery of inverters, residential and C&I energy storage systems (PACK), and energy gateways. Once completed, the facility is expected to produce over 300,000 units annually, providing strong manufacturing support to meet growing demand worldwide.

The facility spans approximately 7.67 hectares (115,000 m²), with an investment of around USD 70 million. It will feature modern production workshops, an R&D and design center, warehouses, a comprehensive office building, and supporting infrastructure. Designed as a next-generation smart factory, the Nantong hub integrates production, R&D, logistics, and operations in line with global best practices. It will set benchmarks in intelligent and digital manufacturing, incorporating a fully digitalized, closed-loop system and a full lifecycle quality traceability framework across supply chain, production, and logistics, ensuring that every process is visible, traceable, and controllable.

Sigenergy continues to advance both capacity expansion and product innovation. Its portfolio covers the world’s first 5-in-1 solar-storage-charging system (SigenStor), advanced C&I solar-storage solutions, and a full range of residential hybrid inverters and microinverters. This diverse lineup consolidates Sigenergy’s competitiveness in the distributed solar and storage sector and has already received strong traction and positive feedback in global markets.