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The 13th Microfilm Production Support Scheme (Music) Matching cum Kick-Off Ceremony

Fostering Cross-Sector Collaboration to Create New Opportunities for Hong Kong’s Film and Music Industries

HONG KONG, Sept. 18, 2025 /PRNewswire/ — The Microfilm Production Support Scheme (Music) (“Support Scheme”), organized by the Hong Kong Association of Interactive Marketing (“AIM”) and sponsored by the Cultural and Creative Industries Development Agency (“CCIDA”), marks its thirteenth year. The Support Scheme continues to unite outstanding local talent in advertising and music to produce 32 original microfilms. It aims to nurture emerging creatives across music, digital advertising, and microfilm production, while encouraging more singers to take part in on-screen performances and advancing the development of Hong Kong’s creative industries in a richer and more diverse direction.

AIM hosts the 13th Support Scheme Matching cum Kick-Off Ceremony at the InnoCentre, Kowloon Tong. Mrs. Lowell CHO, Acting Commissioner for Cultural and Creative Industries, officiates as Guest of Honor, joined by Mr. Francis FONG, Chairman of AIM, to mark the official launch of this year’s edition.

As in previous years, the Support Scheme comprises two tiers: Tier 1 “Advertising Production Start-ups” and Tier 2 “Small Advertising Production Enterprises.” At the ceremony, Tier 1 teams are paired with singers through a drawing of lots, forming 22 creative partnerships. Tier 2 features ten self-formed teams, each comprising a director, scriptwriter, singer, and production company, making their debut at the event.

Each Tier 1 team receives up to HK$130,000 to produce a 4 to 8-minute original microfilm with their matched singer. Tier 2 teams are granted up to HK$240,000 to produce a 12-to-16-minute microfilm with their self-paired singer. The Support Scheme also provides comprehensive training covering scriptwriting, directing, production, and post-production. In addition, a mentoring team of industry experts provides professional guidance to help enhance the quality of the microfilms.

To further support the participating teams, AIM promotes the 32 microfilms through multiple channels, including the Hong Kong International Film and TV Market (FILMART) 2026, television, online platforms, social media, and the Support Scheme’s official website.

To recognize outstanding works, the following awards are presented: “Best Microfilm Production Award,” “Best Microfilm Actor Award,” and “Best Microfilm Actress Award” (each with Gold, Silver, and Bronze distinctions), as well as “Best Microfilm Scriptwriting Award,” “Best Microfilm Cinematography Award,” and “Best Microfilm Art Direction Award.” Winners will be selected by professional judges, while the “Most Popular Microfilm Award” will be determined by public voting. Exceptional teams may also be recommended for international microfilm or short film competitions, further enhancing their exposure and commercial prospects.

The Support Scheme continues to serve as a vital platform for nurturing creative talent and fostering collaboration across Hong Kong’s film and music sectors.

The advertising production companies, directors, and singers participating in the two tiers of the 13th Support Scheme are listed as below:

Tier 1 “Advertising Production Start-ups”

(in alphabetical order of the “Advertising Production Start-ups” company names)

Advertising Production Start-ups and Directors

Singers and Their Record Labels

1

After Life Production

Uni

2

ALVA Digital

One Take Off

3

Beanlet Studio

Andy Lin

4

Best Summer Paradiso

Karen

5

Blind Box Production Ltd.

Heddi

6

Can-Do Production

Tinque Chan

7

Cineapex Inspirations

Jacky Fcy

8

Daylights Pictures

Ritchie

9

Dream Scenario Studio

Mark Chan

10

Hey July Creative

Kylis

11

InMagin Studio Limited

Lap Chau

12

Intrinity Production

DaiKim

13

Media Mix Publishing Ltd.

sharlene

14

Min Min Production

nico

15

NS Production

Mona

16

Recurso Ltd.

KIKO TONG

17

Respect Creative Studio Ltd.

Venus

18

REVERFILMS

Khloe

19

Rockship Studios

Ken Hung

20

Super Common Studios

Ko Tse

21

The Plough Films

Alex

22

TOPPEST PRODUCTIONS CO.

ALL FOR ONE

Tier 2 “Small Advertising Production Enterprises”

(in alphabetical order of the “Small Advertising Production Enterprises” company names)

Company Names

Directors

Singers

Singers’ Record Labels

1

Blue Hour Production

Lee Chan

HOPUI

HOPUI MUSIC

2

Buzz Creative Ltd.

LO Tsz Hin

Noell

Chalk Studios

3

Cineoz Studios

Edwin LAI

Joya

Future Future Limited

4

Concept Pictures Studio

LOK Tsz Hong

Ashia

LAVA MUSIC ENTERTAINMENT

5

CONCRETE LAB

TANG Chiu Tang

YAUYAU

Wicked Awesome Productions

6

Foxter Media Ltd.

Thyestes TONG

Ki Chan

HDP Limited

7

KnoowNO

JK WONG

The Flying Eyeballs

Quantum Industries Limited

8

Kolton Media

WONG Tin Shing

J. Arie

Platform Entertainment

9

Sparkle Image

Lit MA

Modern Children

Playground Studio

10

TREE HEAD PRODUCTIONS

Bonde Sham

6號@RubberBand

R Flat Limited

After the Kick-Off Ceremony, the selected production teams will begin creating their microfilms. These microfilms will be released online in January 2026 and will be showcased at the FILMART 2026, where they will meet with industry professionals and audiences.

For more details about the Support Scheme, please visit: http://www.microfilm-music.hk 

Organizer: Hong Kong Association of Interactive Marketing (AIM)

Lead Sponsor: Cultural and Creative Industries Development Agency of the Government of the Hong Kong Special Administrative Region

Disclaimer: The Government of the Hong Kong Special Administrative Region provides funding support to the project only, and does not otherwise take part in the project. Any opinions, findings, conclusions or recommendations expressed in these materials/events (or by members of the project team) are those of the project organizers only and do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Culture, Sports and Tourism Bureau, Create Hong Kong, the CreateSmart Initiative Secretariat or the CreateSmart Initiative Vetting Committee.

Beauty Amora AU Unveils Exclusive Spring Skincare Offers

SYDNEY, AUSTRALIA – Media OutReach Newswire – 18 September 2025 – Beauty Amora, a fast-growing e-commerce platform offering a diverse range of beauty products from leading Asian brands. This Spring, Beauty Amora is launching three exciting offers to help customers refresh their skincare routines: Spring Glow-Up Sale, medicube Gift with Purchase and New Member Registration Offer.

Promotion: Spring Glow-Up Sale – 14% Off

Use code [BUSGS] to enjoy 14% OFF for selected categories:

Moisturizer & Cream, Essence & Serum, Sunscreen, Facial Cleanser and 10% OFF for other items.

Featured product: Beauty of Joseon – Relief Sun : Rice + Probiotic SPF50+ PA++++

Focuses on those products with moisturizing, strengthen the skin barrier and hydration.

This is a new promotion for Spring. Beauty Amora would like to provide you with some skincare products for Spring in Australia with a discount. The weather in spring is relatively drier, so moisturizing is very important to skincare products.

Promotion: medicube – Gift with purchase

Purchase any medicube skincare devices, that can receive a gift.

Gift: Medicube – Collagen Night Wrapping Mask – 75ml

*For Limited Time Only & All free gifts are subject to availability on a ‘whilst stocks last’ basis.

The wrapping mask use together with the medicube skincare device, to maximize the skincare effectiveness when you are sleeping.

Promotion: New Member Registration – 15% Off on the first shopping

Here is the promote code of new member registration for enjoyment the 15% off [BUFIRST]

Provides special offers to new members, which would hopefully let people have a trial of our products and our platform, to experience the convenience and pleasant online shopping in Beauty Amora.

Skincare products and procedures should not be burdens; everyone has the right to keep their face and the best status of their body. That’s why Beauty Amora provides different kinds of promotions, for those who want to have a quality of skincare products, everyone should focus more on skin care.

Hashtag: #BeautyAmora



The issuer is solely responsible for the content of this announcement.

About Beauty Amora

is dedicated to spotlighting the trendiest products from Asia, Beauty Amora offers 300+ of quality skincare and beauty brands to customers at the most affordable price.

COMEX 2025 Targets Over USD $320 Million in Deals as Oman Showcases Digital Future


MUSCAT, OMAN – Media OutReach Newswire – 18 September 2025 – Business deals exceeding US $320 million was the target of Oman’s flagship technology and investment exhibition, COMEX 2025, making this year’s gathering from September 8 to 11, the most ambitious in the event’s 34-year history.

Here's Amr Baabood welcoming guests and visitors at #COMEX2025, we proudly uphold the authentic values of Oman in welcoming distinguished guests and international delegations. Through a refined and gracious reception, we present a true embodiment of Omani generosity and hospitality. #كومكس2025 #وجهتك_للاستثمار_الرقمي #comex2025 #omantechinvest

“This is the biggest and most important event in Oman when it comes to trade, investment and business,” said Amr Baabood, CEO of the Arabian Research Bureau and organiser of the show.

“We are focused on the future: digital transformation, artificial intelligence, and the technologies that will drive economic growth.”

Record International Participation

More than 35 countries are taking part, with government agencies, private companies, universities and start-ups presenting innovations in Artificial Intelligence (AI), blockchain, fintech, cybersecurity, logistics, and digital government services.

Live-streamed sessions also enabled a global audience to follow key discussions with nearly 60 Omani government entities highlighting progress toward the nation’s Oman Vision 2040 master plan.

“They’re demonstrating what has been achieved and how public–private partnerships can help realise our big vision,” Baabood noted.

This was conceded by his Marketing Director, Huzaifah Ubaid Khan, who highlighted the show’s scale and strategic focus:

“Our main theme is driving investment in tech with Oman, and we’ve built the event around five key growth ecosystems—digital transformation, AI and cybersecurity, e-sports and gaming, agriculture technology, and banking and fintech—all aligned with Oman Vision 2040,” he said.

“With nearly 400 exhibitors overall, and an expected 100,000 visitors, COMEX has become the platform where investors, innovators and policymakers connect.

“Oman’s historic trade links with Asia—from Malaysia and Singapore to Indonesia—make this the right time for Southeast Asian companies to explore opportunities here.”

Khan also pointed to firsts that reflect the exhibition’s growing clout: a major China pavilion, strong GCC representation, and even an Oman Air aircraft carrying the COMEX logo—a national first.

“We’ve taken bold steps in marketing and partnerships this year, and the response has been incredible,” he said.

Technology for Every Sector

Dedicated zones covered government e-services, banking and fintech, insurance technology, cybersecurity, and advanced logistics.

Exhibitors showcased everything from telemedicine platforms and health-tracking apps to next-generation shipping and aviation monitoring systems.

“Oman is globally recognised for its strong cybersecurity framework,” Baabood said.

“We have the world’s leading companies here, ensuring data is as safe as possible.”

A Gateway for Asia and Beyond

Baabood also highlighted opportunities for Southeast Asian businesses—particularly from Malaysia, Singapore, Indonesia and the Philippines—to collaborate with Omani counterparts.

“Oman’s location makes it a natural hub for the GCC, Africa and Europe,” he explained.

“Asian countries lead in technologies such as semiconductors. We invite their companies to set up here and serve the wider region.”

Sustainability and Green Energy

Sustainability was also central to the show with Oman investing heavily in green hydrogen and renewable energy.

Major companies at COMEX also demonstrated how digital tools—from drones to smart tracking—can cut environmental impact.

“Digital transformation is not just about technology,” Baabood stressed.

“It’s about people, skills and mindset.”

Youth and Teamwork

Despite his own youth, Baabood credits COMEX’s success to a “young, energetic team—most of them under 28 years old—and the strong support of experienced partners.”

“Age is not a factor when everyone works together toward a common vision,” he said.

Cybersecurity Front and Center

Among the standout participants at COMEX was Dreamlab Technologies, unveiling a suite of locally developed cybersecurity tools aimed at strengthening digital sovereignty across the Middle East and beyond.

“We are proud to present advanced solutions built in Oman by Omani professionals,” said Mohammed Al Mamari, General Manager of Business Development.

“From our base in Muscat we are driving innovation that serves not only the Middle East but also international markets, making Oman a regional hub for cybersecurity solutions.”

Government Innovation on Display

Highlighting the public sector’s role, Sultan Al Subhi, representing Oman’s Ministry of Culture, Sports and Youth, showcased an eight-week national hackathon that recently earned a Guinness World Record for the longest digital government transformation project.

“We opened 28 real-world challenges to anyone—regardless of age or nationality—and were amazed by the creativity,” Al Subhi said.

“COMEX is the perfect platform to reveal these solutions because it brings the private sector, public sector and international innovators together under one roof.”

Among the ministry’s prototypes are a multiplayer online version of traditional Omani games, a sports-complex maintenance platform, and Melody, a new social network and credentialing system for musicians.

“We offer partners a safe sandbox to pilot technology live, plus access to Middle Eastern culture and markets,” Al Subhi added.

Palestinian Tech Gains Momentum

First timers at COMEX, Technology for Youth and Jobs Project (TechStart) which aims to increase economic opportunities for IT service firms in the West Bank and Gaza, brought 18 pioneering Palestinian IT firms ranging from semiconductor innovators to cybersecurity specialists.

“In just the first two days, three of our companies signed MOUs or contracts with partners here in Oman—something almost unheard of at exhibitions like these,” said Feras Nasr, who co-leads the initiative with Farah J Said.

“Our goal is to help Palestinian IT companies build capacity, secure market access and attract investors,” Farah added.

“We see strong future opportunities in Southeast Asia—in Malaysia, Singapore and Indonesia—where the interest in Palestinian technology and the openness to collaboration are very encouraging.”

Looking Ahead

Moving forward, Amr Baabood envisions COMEX continuing to grow in both scale and quality.

“It’s about the value and results for everyone—whether they come to learn, network, invest or simply experience Oman’s hospitality,” he said.

“Our goal is to drive the nation’s digital economy from 2 percent to 10 percent of GDP and position Oman as one of the world’s most advanced, connected nations.”

Hashtag: #COMEX2025

The issuer is solely responsible for the content of this announcement.

Discover Asia’s Leading Children’s Book Fair — CCBF 2025, Shanghai · November 14–16, 2025


SHANGHAI, CHINA – Media OutReach Newswire – 18 September 2025 – The 12th edition of the China Shanghai International Children’s Book Fair (CCBF) will take place from November 14-16, 2025, in Shanghai at the Shanghai World Expo Exhibition & Convention Center (SWEECC). As the leading event in the Asia Pacific region dedicated to children’s books and content, the 2025 CCBF is expected to host 500 exhibitors from over 35 countries and regions, with an anticipated attendance of more than 50,000 visitors across a 25,000-square-meter exhibition area.

CCBF serves as a bridge between Eastern and Western children’s publishing, promoting Chinese original titles globally and showcasing emerging talent from China and the Asia-Pacific region. The fair provides a professional platform for publishers, agents, booksellers, illustrators, digital creators, and cross-media partners to connect, collaborate, and explore new business opportunities.

CCBF 2025 is divided into two zones: the Copyright Zone and the Hybrid Zone. The Copyright Zone focuses on copyright exchange and international collaboration, open exclusively to industry professionals. The Hybrid Zone combines copyright activities with marketing, distribution, channel development, promotion, and retail. CCBF warmly welcomes global industry colleagues and all book lovers to join this vibrant celebration of children’s books!

Highlights of CCBF 2025

This year, Belgium, Canada, France, Italy, Japan, Norway, Poland, Russia, South Korea, UAE, and the UK will have national pavilions. Featured areas like the BOP – Bologna Prize Lounge, Asia Pacific New Entry Lounge, and Rights Centre will return, alongside the Belt and Road Lounge for publishers from BRI partner countries.

A new Cross Media Lounge highlights global projects such as BookGorae (South Korea), Frontiers for Young Minds (Switzerland), MakeMake Digital Library (Colombia), and Weltentdecker (Germany). The BOP Lounge features award-winning houses like Andersen Press (UK), Barefoot Banana (Thailand), Enchanted Lion Books (USA), and Fukuinkan Shoten (Japan). The Asia Pacific New Entry Lounge hosts Difference Engine (Singapore), Jiaxuan Publishing (Malaysia), Pepper Dog Press (Singapore), and Sekaibunkasha Group (Japan).

Leading Chinese publishers—China Education Publishing, Shanghai Century Publishing, CITIC Press, 21st Century Publishing, Jieli Publishing, Phoenix Juvenile, New Buds, and Hunan Juvenile & Children’s Publishing—along with private publishers like Post Wave Kids, Little Bean, Lelequ, CheerFly Culture, and Jojo Reading, will participate in discussions and exchanges throughout the fair.

Spotlight on New Books

The new Spotlight on New Books will showcase 2025’s latest titles and features book launches, author signings, and rights-purchasing sessions. It provides a unique platform for visitors to acquire rights, forge partnerships, and connect directly with leading global children’s publishers.

Leverage Professional Expertise and Discover Innovative Trends

CCBF 2025 will host 17 professional conferences and seminars fostering cross-cultural exchange across the children’s content industry. A highlight is the International Children’s Reading Promotion Forum, supported by the Shanghai Press & Publication Administration and the International Board on Books for Young People (IBBY), which will gather global leaders, including Gvantsa Jobava (IPA President) and Basarat Kazim (IBBY President) to discuss best practices, digital innovation, and building safe, multicultural reading environments. Other sessions will feature the Award Winners’ Series, insights into Chinese and global book retail markets, and discussions on IP operations, AI in education, Asian children’s content, and innovative storytelling.

A stellar lineup of distinguished guests—including Sydney Smith, winner of the 2024 Hans Christian Andersen Award for Illustration; Shinsuke Yoshitake, recipient of the Bologna Ragazzi Special Prize; Leo Timmers, eight-time winner of the Children’s and Youth Jury Award and recipient of the Bookpeacock Award; Alessandro Sanna, winner of multiple Premio Andersen awards; Øyvind Torseter, winner of the Bologna Ragazzi Award and Norwegian Book Art Prize; and Matthew Forsythe, Oscar-nominated artist—will be participating in the Fair.

Children Plus: Comics

CCBF will spotlight comics with the special exhibition Children Plus – COMICS: Exploring the World, One Bubble at a Time. The exhibition is divided into two sections: international and domestic. The international section is curated by an international team led by Grazia Gotti, Co-founder of the Giannino Stoppani Children’s Bookshop and the Accademia Drosselmeier, with Marina Lepore (Secretariat and Coordination, Cooperativa Giannino Stoppani/Accademia Drosselmeier) and Mariaelena Schiavo (Special Projects for BCBF and CCBF). The Chinese section is curated by Fei Jia, Senior Editor and Picture Book Researcher.

The exhibition will showcase around 200 international titles, celebrating comics as an art form and a learning tool. A dedicated panel will explore this theme in depth.

Emerging talent in Illustration

The Golden Pinwheel Illustration Exhibition highlights 69 outstanding shortlisted works from the 2025 Golden Pinwheel Young Illustrators Competition, alongside the launch of the official Yearbook, bringing the latest in cutting-edge illustration to the public.

The Illustrators Survival Corner, in partnership with Mimaster Illustrazione, will feature 11 masterclasses, 9 creative workshops, and 27 one-on-one mentorship sessions, empowering young illustrators to showcase their skills, improve their craft, and engage in valuable exchanges.

Registration & Travel Info

Professionals in children’s publishing, education, entertainment, and related fields can attend free of charge. Using the online matchmaking system, visitors and buyers can browse exhibitors and products, schedule pre-arranged meetings, and expand their professional networks. Visit www.ccbookfair.com/en or search “ccbookfair” for details.

International visitors should apply for a visa in advance. China offers visa-free entry for 47 countries and a 240-hour transit visa-free policy for 55 countries. For further information or consultation on relevant visa exemption policies, please visit www.visaforchina.cn

Media Contact
Ms. Yvonne Sun
T: +86-33683186*8044 | E: yvonne.sun@bfchina.net

Hashtag: #CCBF

The issuer is solely responsible for the content of this announcement.

About CCBF

Approved by the Shanghai Press & Publication Administration, CCBF is organized by Shanghai Xinhua Distribution Group Co., Ltd., China Education Publishing & Media Group Ltd., and China Universal Press & Publication Co., Ltd., co-organized by Ronbo BolognaFiere Shanghai Ltd., and powered by the BolognaFiere Group. Since its debut in 2013, CCBF has grown into the leading fair for children’s content in the Asia Pacific region.

In 2024, CCBF hosted 497 exhibitors from 32 countries and regions, with 41,263 visitors, including 17,081 professionals, attending over the three-day event.

For more information, please contact:

Global Times: Technology empowers silver economy; digital elderly care faces broad opportunities

BEIJING, Sept. 18, 2025 /PRNewswire/ — Driven by both policy guidance and market forces, China’s silver economy is rapidly developing, creating vast opportunities. The silver market has shown new progress, including sustained vitality of main entities, continued boom in key areas, the prominent role of consumption in driving investment, and accelerated advancement of industrial integration and regional coordination.

China’s silver economy is entering a new stage of development. A new development pattern is emerging – marked by consumption upgrades, technological empowerment, industry-finance integration, and regional coordination. The silver economy has evolved from a concept to action, becoming an important action in national strategies such as actively responding to population aging, expanding domestic demand, and achieving high-quality development.

With moderate growth in per capita consumption, the scale of China’s silver economy is expected to reach 19.1 trillion yuan ($2.68 trillion) by 2035, accounting for 27.8 percent of total consumption, according to the Fudan Institute on Aging.

In recent years, with the support of technologies such as artificial intelligence (AI), the elderly care industry has become increasingly intelligent and digitalized, with smart elderly care emerging as a new growth track in the silver economy. As technological innovation continues to expand, application scenarios for smart elderly care are becoming increasingly diverse. Intelligent nursing robots, smart wearable devices, and personal health management systems are helping older adults better enjoy a smarter lifestyle.

Powered by modern technologies such as the internet, big data, and AI, smart elderly care models now provide seniors and institutions with real-time, efficient, and low-cost services. Looking ahead, the digital transformation and intelligent upgrading of the elderly care industry are expected to bring new growth points to economic development and give rise to new fields and new tracks.

According to the 55th Statistical Report on China’s Internet Development released by the China Internet Network Information Center, as of December 2024, internet users aged 50 and above accounted for 34.1 percent of the total, up from 32.5 percent a year earlier. The internet continues to penetrate deeper into middle-aged and elderly groups.

The silver generation has shown strong adaptability to the internet and enthusiasm for digital life. Their online habits are comparable to those of younger groups. Online shopping, web browsing, mobile payments, and video streaming have become daily routines, enriching their lifestyles with diverse experiences.

Since 2017, the Ministry of Industry and Information Technology has launched nationwide pilot projects for smart health and elderly care, focusing on building platforms, resource integration, database utilization, terminal convergence, and smart devices. Such pilots have spurred breakthroughs and accelerated the industry’s development.

Take healthcare as an example. China is strengthening digital and intelligent services in local healthcare, promoting telemedicine, and expanding online medical care. E-commerce platforms are also actively entering internet healthcare, offering innovative products that enrich elderly care financial services and provide seniors with integrated healthcare solutions.

With breakthroughs in computing power, algorithms, and AI, technology is penetrating the silver economy more deeply. The interaction between the silver economy and technology innovation has become a key arena of global competition. Meanwhile, global population aging and digital globalization may offer China a strategic opportunity to lead in this field.

To further promote the deep integration of technological and industrial innovation in the silver economy, ensuring that technology is truly “age-friendly” and “benefits the elderly,” it is essential to coordinate efforts across multiple areas, including policy, capital, application scenarios, and talent.

First, China should leverage its vast market to build competitive advantages across the entire value chain – from application integration and research and development to capital and talent development – creating an open, innovative ecosystem driven by markets, supported by applications, and rooted in talent.

Second, it is crucial to closely follow global frontiers in silver economy technologies, strengthen international exchanges and cooperation, and nurture globally competitive technology-driven silver economy enterprises in the sector.

Third, it is also important to use the value chain to guide major breakthroughs in aging-related technologies, fostering interaction between basic research and industrial transformation to create a virtuous cycle.

Fourth, building a sound digital governance ecosystem to foster a favorable environment for the silver economy is also critical. Silver consumption is personalized and scenario-based, requiring diverse consumption settings, display platforms, and convenience-enhancing mechanisms.

Amid the dual trends of aging and digitalization, bridging the digital divide for seniors and elderly care workers demands multi-pronged efforts. Legal and regulatory governance is needed to ensure a healthy digital environment, integrate digital tools into seniors’ daily lives, and make the digital economy a key driver of the silver economy.

Thai Forces Fire Tear Gas in Border Stand-off With Cambodians

Thai Forces Fire Tear Gas in Border Stand-off With Cambodians
Thai forces fired rubber bullets and tear gas during a stand-off with Cambodian protesters along their disputed border on September 17, Bangkok's military said, a move that Phnom Penh stated injured more than 20 people. (Photo by Handout / Agence Kampuchea Press (AKP) / AFP)

AFP – Thai forces fired rubber bullets and tear gas during a stand-off with Cambodian protesters along their disputed border on 17 September, Bangkok’s military said, a move that Phnom Penh stated injured more than 20 people.

Neuronata-R® Phase 3 Results Confirm Subgroup Benefit at PACTALS 2025, Strengthening Biomarker-Driven Pathway

Meaningful improvements confirmed in slow-progressor subgroup; biomarker reductions support precision-medicine approach and potential FDA accelerated pathway

SEOUL, South Korea, Sept. 18, 2025 /PRNewswire/ — CorestemChemon Inc. (KOSDAQ: 166480) announced today that it has presented key findings from the Phase 3 ALSummit trial of Neuronata-R® (lenzumestrocel), an autologous bone marrow-derived mesenchymal stem cell (MSC) therapy for amyotrophic lateral sclerosis (ALS), at the PACTALS 2025 congress in Melbourne, Australia.

The first session, chaired by Professor Seung-Hyun Kim of Hanyang University Hospital — a global leader in stem cell-based ALS research — brought together a panel of seven distinguished ALS experts from six countries. As part of the panel, Dr. Ryung-A Lee (Head of R&D Innovation, CorestemChemon) introduced the company and shared a brief overview of the Phase 3 trial results.

In the second session, the full Phase 3 clinical trial (ALSUMMIT trial) results were formally presented by Professor Ki-Uk Oh (Department of Neurology, Advanced Regenerative Medicine Center, Hanyang University Hospital, and principal investigator of the ALSUMMIT trial).

A presentation on CorestemChemon’s ‘Neuronata-R’ at the International ALS Conference PACTALS 2025 held in Melbourne, Australia (Photo = CorestemChemon)
A presentation on CorestemChemon’s ‘Neuronata-R’ at the International ALS Conference PACTALS 2025 held in Melbourne, Australia (Photo = CorestemChemon)

Subgroup Analysis Demonstrates Statistically Significant Benefit

While the overall trial did not meet its primary and secondary endpoints, Neuronata-R® showed meaningful efficacy in patients with slower disease progression.

At 12 months, participants in this subgroup receiving Neuronata-R® achieved:

  • ALSFRS-R (functional rating scale): 31.2 vs. 26.4 in placebo (p=0.001)
  • CAFS (Combined Assessment of Function and Survival): 20.95 and 24.78 vs. 17.92 in placebo (p=0.024; p=0.041)
  • SVC (slow vital capacity, respiratory function): 62.2% vs. 50.6% in placebo (p=0.017, Study Group 2)

These findings confirm Neuronata-R®‘s potential to preserve function and respiratory capacity in ALS — outcomes directly linked to quality of life and survival.

Biomarker Data Underscore Neuroprotective Effect

Biomarker analysis revealed sustained reductions in neurofilament light chain (NfL) and MCP-1, indicating a strong link between neuroprotection and clinical outcomes.

This strengthens the case for biomarker-guided patient stratification and a precision-medicine strategy in ALS drug development, reflecting the evolving global regulatory landscape.

Regulatory Pathway Toward Accelerated Approval

CorestemChemon stated that the PACTALS 2025 results mark an important step for regulatory discussions. The company plans to request a Type-C meeting with the U.S. Food and Drug Administration (FDA) in Q4 2025 to discuss the dataset and biomarker-driven subgroup efficacy.

Based on this discussion, CorestemChemon plans to submit a Biologics License Application (BLA) within 2026, aiming to pursue an accelerated approval pathway aligned with precedents in ALS, including FDA’s decision on Tofersen.

Innovative Stem Cell Therapy

Neuronata-R® uniquely addresses the complex mechanisms of ALS by leveraging MSCs derived from the patient’s own bone marrow. These cells exert anti-inflammatory and immunomodulatory effects, protect motor neurons, and, through paracrine signaling, secrete trophic factors, cytokines, and extracellular vesicles that modulate the microenvironment and reduce neuroinflammation. By targeting these underlying pathological processes, Neuronata-R® is designed to interrupt the neurodegenerative cascade.

About Neuronata-R®

Neuronata-R® (Lenzumestrocel), developed and commercialized by CorestemChemon Inc. (KOSDAQ: 166480), is an autologous MSC therapy for ALS patients. The company began ALS research in 2002 and obtained MFDS approval for Neuronata-R® in 2014. To date, it has been administered to more than 400 commercial patients and 190 clinical trial participants with no treatment-related serious adverse events reported.

Neuronata-R® holds Orphan Drug Designation from both the U.S. FDA (2018) and the EMA (2019). CorestemChemon completed a Phase 2 trial (NCT01363401) in 2014 and its Phase 3 trial (NCT04745299) in 2024; the final CSR has been submitted to the MFDS.

 

/C O R R E C T I O N — CAIR/

In the news release, “EchoCare” Ultrasound Large Model Launched in Hong Kong as CAIR Showcases Large-Scale Ultrasound Dataset Training Achievements, issued 17-Sep-2025 by CAIR over PR Newswire, we are advised by the company that the headline, 2nd paragraph, 6th paragraph, and 7th paragraph have been updated. The complete, corrected release follows:

“EchoCare” Ultrasound Foundation Model Launched in Hong Kong as CAIR’s New Breakthroughs Propel AI Ultrasound into the Era of Large Models

HONG KONG, Sept. 17, 2025 /PRNewswire/ — Amid the global surge in rapid advancements in artificial intelligence, the healthcare sector is entering a critical phase of intelligent transformation. As a vital tool in clinical diagnosis, ultrasound imaging has long been plagued by issues such as low efficiency, inconsistent diagnostic standards, and insufficient AI model accuracy. These challenges urgently call for technological breakthroughs and industrial collaboration. Against this backdrop, Centre for Artificial Intelligence and Robotics (CAIR), Hong Kong Institute of Science & Innovation (HKISI), Chinese Academy of Sciences unveiled its latest scientific achievement – the “EchoCare” Ultrasound Large Model – on 17th September in Hong Kong.

At the press conference, Prof Hongbin Liu, Director and Professor of CAIR, Prof Gaofeng Meng, Deputy Director and Professor of CAIR, Prof Jiebo Luo, Member of Academia Europaea and the US National Academy of Inventors, Prof Randolph Hung-leung Wong, Chief of the Cardiothoracic Surgery at The Chinese University of Hong Kong (CUHK), were joined by numerous renowned scholars, clinical experts, and more than ten media representatives to witness this milestone breakthrough in AI-powered ultrasound medicine.

Pioneering Structured Contrast Self-Supervised Learning Framework

The “EchoCare” Ultrasound Large Model was trained on the first ultrasound image dataset known to exceed 4 million images. The model introduces a “Structured Contrast Self-Supervised Learning Framework”, which leverages hierarchical tree labels derived from medical priors to enable multi-label semantic relational structured learning and implicit encoding. Through techniques such as Masked Image Modelling (MIM), Adaptive Hard Patch Mining, and Progressive Training, the model effectively enhances its ability to model the deep semantic features of ultrasound images and improves generalisation performance.

Test results demonstrate that “EchoCare” achieves state-of-the-art (SOTA) performance across seven medical tasks, including image segmentation, classification, detection, regression, and enhancement, as well as in over ten downstream applications. On average, it delivers a 3%-5% improvement compared with current SOTA methods.

A Major Milestone for Inclusive Smart Healthcare

In his opening remarks, Prof Jiebo Luo congratulated the successful development of the “EchoCare” Ultrasound Large Model and highly praised it as another significant breakthrough in the deep integration of AI and medical applications. He noted that the implementation of “EchoCare” in routine hospital examinations can significantly reduce reliance on medical specialists while assisting doctors in making diagnoses more efficiently and accurately. This technology is expected to substantially improve the efficiency of medical services while providing greater opportunities for the optimal allocation of healthcare resources.

“Listening to Sound, Grasping Principles”

At the press conference, Prof. Gaofeng Meng, Deputy Director of CAIR, explained that the name “EchoCare” originates from the idiom “Listening to Sound and Grasping Principles” (Ling Yin Cha Li) in Liu Xie’s The Literary Mind and the Carving of Dragons (Wenxin Diaolong • Zhiyin). The text notes that “One becomes proficient in music only after mastering a thousand melodies, and gains insight into weaponry only after observing a thousand swords.” which aligns closely with the philosophy behind developing the ultrasound large model. He further introduced that EchoCare innovatively adopts a structured contrastive self-supervised learning approach, enabling feature learning and downstream task decoupling without the need for extensive data annotation, thereby achieving the internalization of prior knowledge in the ultrasound domain and facilitating cross-task knowledge transfer.

Prof. Meng emphasized that, unlike traditional large models, EchoCare innovatively adopts a structural self-supervised learning approach. It removes the need for extensive data annotation, enables feature learning, and decouples downstream tasks, thereby internalizing prior knowledge in ultrasound and facilitating cross-task knowledge transfer.

He also showcased the model’s technical highlights, data advantages, and application results. Specific case validations included 1,556 ovarian tumor ultrasound cases at Qilu Hospital of Shandong University and more than 1,000 thyroid ultrasound examinations at Xiangya Hospital of Central South University, where EchoCare significantly outperformed existing state-of-the-art methods.

Relieving Physicians, Benefiting Patients, and Offering Immense Clinical Value

The standardized analytical capabilities of “EchoCare” can effectively reduce the rates of missed and misdiagnosed major diseases, significantly enhancing the efficiency and standardisation of clinical diagnosis. It provides robust technical support for frontline medical practitioners.

During the case-sharing segment, Prof Randolph Hung-leung Wong from CUHK first presented retrospective validation results for the detection and analysis of aortic aneurysms using “EchoCare” in cardiac ultrasound. He also envisioned the potential clinical value of integrating this large model with robotic technology. In the live demonstration, he showcased two ultrasound scanning videos, where the model rapidly captured and analysed the key medical information, successfully identifying abnormal cases and automatically generating ultrasound reports for the doctors’ reference.

Various Views: Technology for the People, AI Deeply Rooted in Reality

During the media Q&A session, Prof Hongbin Liu, Prof Gaofeng Meng and Prof Randolph Wong answered questions from media representatives, such as Phoenix TV. They engaged in in-depth discussions on the technical details, clinical applications, and commercialisation pathways of the EchoCare Ultrasound Large Model. Following the Q&A, the media representatives conducted exclusive interviews with the invited guests and visited the Embodied-AI Surgery Platform developed by CAIR, where they experienced CAIR’s latest AI healthcare achievements up close.

The “EchoCare” Ultrasound Large Model, open-sourced by the Centre for Artificial Intelligence and Robotics (CAIR), Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, breaks down the compatibility barriers between traditional ultrasound devices and unlocks the value of multi-centre data, providing medical institutions with reusable AI infrastructure. This achievement not only accelerates the large-scale deployment of ultrasound AI but also injects sustained innovation into the advancement of the smart healthcare industry.

Released by 

The Centre for Artificial Intelligence and Robotics (CAIR).

Established in 2019, the Centre for Artificial Intelligence and Robotics (CAIR) is one of the two centres under Hong Kong Institute of Science & Innovation (the only directly affiliated research institute of Chinese Academy of Sciences in Hong Kong).

CAIR is dedicated to integration and  innovation of  artificial intelligence and life sciences, conducting research in three main areas: Multimodal AI Large Model, Embodied Intelligent Robots, and Intelligent Sensing Technologies. CAIR is a key institution supported by Hong Kong’s InnoHK initiative in the field of AI. It is among the few institutions globally that systematically carry out research and development of AI systems for medical and healthcare applications, as well as their technological transformation.