SHANGHAI, Oct. 8, 2025 /PRNewswire/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on developing innovative CAR T-cell therapies, announces that the results of CT071 (an autologous CAR T-cell product targeting GPRC5D) for the treatment of relapsed/refractory multiple myeloma (R/R MM) in an investigator-initiated trial (NCT05838131) have been published in The Lancet Haematology. The article was titled “GPRC5D-targeted CAR T-cell therapy (CT071) in patients with relapsed or refractory multiple myeloma: a first-in-human, single-centre, single-arm, phase 1 trial”.

This trial aimed to assess the safety, preliminary activity of CT071 in R/R MM. 20 patients received CT071 infusion. Patients had received a median of 5 prior lines of therapy (IQR 3.0-6.5); 19 (95%) were double-class refractory, 13 (65%) were triple-class refractory, 5 (25%) were penta-drug refractory, 10 (50%) had received autologous stem cell transplantation (ASCT), and 5 (25%) had relapsed after CAR T-cell therapies targeting BCMA or BCMA/CD19. Four (20%) patients had extramedullary disease (EMD), 14 (70%) had ≥1 high-risk cytogenetics and 19 (95%) had a Revised International Staging System (R-ISS) 2 or 3 disease at baseline.

No dose-limiting toxicities (DLTs) were observed. The recommended phase 2 dose was determined at 0.1×10⁶ CAR T cells/kg. Cytokine release syndrome occurred in 12 patients (60%), all graded as 1 or 2. No Grade ≥3 cytokine release syndrome (CRS) occurred. One patient (5%) experienced Grade 3 immune effector cell-associated neurotoxicity syndrome (ICANS). No treatment-related deaths occurred.

With a median follow-up of 10.71 months (IQR 6.13-12.02), the objective response rate (ORR) was 100% (95%CI, 83.2-100). 10 (50%) patients achieved stringent complete response (sCR), 4 (20%) had very good partial response (VGPR) and 6 (30%) had partial response (PR). One patient with a large EMD (125 mm×99 mm at baseline) achieved a 67.6% reduction at month 10 with ongoing PR. All 5 patients previously treated with an anti-BCMA CAR T (n=1) or anti-BCMA/CD19 CAR T (n=4) responded; 2 achieved PR, 1 achieved VGPR and 2 achieved sCR. 18 of 20 (90%) evaluable patients achieved MRD negativity at 10⁻⁶ including all 10 with CR or sCR. Median time to MRD negativity was 29 days (IQR 29-29). Median duration of response (DoR), progression-free survival (PFS) and overall survival (OS) were not reached. The data cutoff for all analyses was December 9, 2024.

About CT071
CT071 is a CAR T-cell therapy candidate developed utilizing the proprietary CARcelerate^® platform targeting GPRC5D for the treatment of relapsed/refractory multiple myeloma (R/R MM) or plasma cell leukemia (PCL). Initiated trials include an investigator-initiated trial for R/R MM or PCL in China (NCT05838131), and an investigator-initiated trial for newly diagnosed multiple myeloma (NDMM) in China (NCT06407947).

About CARsgen Therapeutics Holdings Limited
CARsgen is a biopharmaceutical company focusing on developing innovative CAR T-cell therapies to address the unmet clinical needs including but not limited to hematologic malignancies, solid tumors and autoimmune diseases. CARsgen has established end-to-end capabilities for CAR T-cell research and development covering target discovery, preclinical research, product clinical development, and commercial-scale production. CARsgen has developed novel in-house technologies and a product pipeline with global rights to address challenges faced by existing CAR T-cell therapies. Efforts include improving safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs, etc. CARsgen’s mission is to be a global biopharmaceutical leader that provides innovative and differentiated cell therapies for patients worldwide and makes cancer and other diseases curable.

Forward-looking Statements
All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group’s current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group’s control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading “Principal Risks and Uncertainties” in our most recent annual report and interim report and other announcements and reports made available on our corporate website, https://www.carsgen.com. No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release.

SINGAPORE, Oct. 8, 2025 /PRNewswire/ — Taking place on 18 & 19 November 2025 at The Westin hotel in Singapore, IFF Asia will focus on bridging the region’s infrastructure financing gap in high-growth markets – showcasing investable projects and fostering collaboration among investors, developers and financiers.

“IFF Asia is built by investors, for investors. We will accelerate the projects that define the region’s next decade.” – Manju Dalal, Editor & APAC Head, IJGlobal

Agenda highlights include:  

• The energy transition: exploring the investment opportunities across renewables and the technologies helping to accelerate deployment, from green hydrogen to storage and hybrid solutions.
• Innovative financing: focusing on blended and sustainable structures in action, balancing de-risking with returns and the role of green bonds, SLLs and ESG frameworks. 
• Financing the data-centre boom: deep-diving into the pipeline outlook, hyperscale-driven growth, mid-market roles, and the clean-power/offtake solutions emerging across APAC. 
• Debt & private credit: a view on lenders’ capacity by sector, evolving pricing, and where direct lenders are prepared to commit capital in the year ahead.  
• Building resilient assets: examining practical approaches to risk allocation and structures that hold up under geopolitical stress. 
• Market opportunities: in-depth analysis of local markets across ASEAN, Northeast Asia, and Australia, with takeaways from live and recent transactions. 

Confirmed speakers include leaders from JERA Asia, Keppel, Acciona Energía, Siemens Bank, Pentagreen Capital, Octopus Energy Generation, AirTrunk, Marubeni, Brookfield, GIC, KKR, ESR Group, BluPine Energy, Infrastructure Asia, Actis, TotalEnergies, HSBC, the World Bank, and many more. 

IJGlobal’s editorial team, comprising Manju Dalal, Angus Leslie Melville and Ila Patel, will chair and moderate the conference.

Green Street’s Cedrik Lachance, EVP, Director of Research is also set to moderate the Australian energy and infrastructure market panel. 

IFF Asia 2025 will examine capital deployment, financing structures, and project pipelines across the APAC region, with a focus on execution. It convenes investors, sponsors and lenders for focused sessions on risk allocation, returns and delivery. Full details and registration are available on the event website.  

About IJGlobal:
IJGlobal is a single source of data, intelligence and analysis covering all aspects of the international infrastructure and energy finance industry. IJGlobal delivers news, transaction and investor/fund data, and events for global infrastructure to market participants worldwide, and through a comprehensive database that encompasses all infrastructure transaction participants, exclusive daily news, live League Table rankings, and more. IJGlobal is headquartered in London and was founded in 1997. For more information, please visit https://hub.ijglobal.com/.

About Green Street
Green Street is a forward-thinking real assets company at the forefront of transforming the commercial real estate market with cutting-edge predictive analytics, data-driven insights, and actionable intelligence. With over 40 years of expertise, Green Street empowers investors, lenders, and stakeholders across the U.S., Canada, Europe, and Australia to make optimized investment and strategic decisions. 

Media contact:

greenstreet@nextpr.com

PENANG, Malaysia, Oct. 8, 2025 /PRNewswire/ — QNET, a leading global lifestyle and wellness direct selling company, concluded its spectacular 27th-anniversary convention, V-Malaysia 2025, in Penang this week. The event, endorsed by Tourism Malaysia, welcomed over 10,000 independent distributors from more than 30 countries, serving as a powerful testament to the company’s global community and the significant economic benefits of its flagship events.

V-Malaysia 2025 Opening Ceremony

Held for the 13th consecutive year in Penang, the five-day convention underscored Malaysia’s position as a premier MICE (Meetings, Incentives, Conferences, and Exhibitions) destination. The partnership with Tourism Malaysia highlighted how major corporate events drive tourism, hospitality, and local economic activity.

A Global Stage for Innovation and Culture

The convention opened with a vibrant celebration of Malaysian culture at the SPICE Arena, featuring music, dance, and the appearance of ‘Wira’ and ‘Manja’, the Malayan sun bear mascots for the upcoming Visit Malaysia Year 2026 campaign. This fusion of global business and local tradition set the stage for an event focused on empowerment and connection.

Driving Entrepreneurship with Cutting-Edge Products

V-Malaysia 2025 served as the launchpad for QNET’s latest innovations designed to enhance personal wellness and lifestyle. Key launches included:

• Harmoniq-Snooze: An adhesive bio-signaling patch designed to promote deeper, restorative sleep.
• Qwik-Vibe: A clean, fast-acting oral strip for instant energy and mental focus.
• The Bernhard H. Mayer^® PTLuxe & Insignia Collections: New lines of platinum jewellery symbolizing resilience and style.

“For 27 years, QNET has been about empowering individuals to take control of their health and financial future,” said Trevor Kuna, Chief Marketing Officer at QNET. “V-Malaysia is the physical embodiment of our mission—a place where innovation meets culture, inspiring our entrepreneurs from Sub-Saharan Africa, the Middle East, Central Asia, and Southeast Asia to achieve more.”

Inspiring a Global Audience with a Story of Resilience

A defining moment of the convention was the keynote address by Sparsh Shah, a global youth icon, motivational speaker, and recording artist. Born with Osteogenesis Imperfecta (Brittle Bone Disease), Sparsh has overcome profound physical challenges to become a beacon of resilience and determination. He captivated the audience of thousands by sharing his life’s journey, weaving his powerful narrative with his original music. His message urged every participant to recognize their own unique potential and to harness an unstoppable mindset in the pursuit of their ambitions.

“Having Sparsh Shah share his incredible story was a deeply moving experience for our global community,” said Trevor Kuna, Chief Marketing Officer at QNET. “He embodies the very essence of RYTHM — rising above circumstances to inspire others. His presence reminded us all that entrepreneurship is not just about business success, but about the power of the human spirit to overcome any obstacle.”

A Legacy of Empowerment and Economic Partnership

Beyond the celebration, QNET used the occasion to announce its next major regional convention: V-Africa 2026, scheduled for the first quarter of 2026 in Ghana. This strategic move signals QNET’s commitment to fostering entrepreneurship and contributing to economic development in key growth markets.

“Our conventions are more than just meetings; they are economic partnerships with host nations,” Kuna added. “The success of V-Malaysia demonstrates how business tourism creates a positive ripple effect. We are thrilled to build on this legacy and bring the same energy and opportunity to Ghana with V-Africa 2026, further solidifying our commitment to empowering entrepreneurs across the African continent.”

V-Malaysia is rooted in QNET’s mission of RYTHM – Raise Yourself To Help Mankind, serving as a global platform for entrepreneurship, personal growth, and community.

For more information, visit www.qnet.net.

About QNET

QNET is a global lifestyle and wellness company that uses a direct selling business model to offer a wide selection of exclusive products designed to help people live healthier, more balanced lives. Since 1998, QNET’s innovative products and e-commerce-driven model have helped build a worldwide community of customers and microentrepreneurs, guided by the mission of RYTHM – Raise Yourself To Help Mankind.

QNET is a member of the Direct Selling Association in several countries, the Hong Kong Health Food Association, the Health Supplements Industry Association of Singapore, and more. The company is also a partner in global sports sponsorships, including as the official direct selling partner of Manchester City Football Club and the Confederation of African Football (CAF), underscoring its commitment to excellence and global reach.

Discover more at www.qnet.net.

NEW YORK, Oct. 8, 2025 /PRNewswire/ — Newmark Group, Inc. (Nasdaq: NMRK) (“Newmark” or “the Company”), a leading global commercial real estate advisory firm, announces the acquisition of RealFoundations, Inc. and its subsidiaries and affiliates (collectively referred to herein as “RealFoundations”), a leading global professional services firm focused solely on the real estate industry through its management consulting and managed services, based in Dallas, Texas. The acquisition accelerates the expansion of Newmark’s Investor Solutions suite, enhancing the Company’s ability to deliver market-leading fund and asset management capabilities for institutional clients across the U.S., Europe and Asia-Pacific.

Image courtesy of Newmark. Back Row, left to right: Chris Shaida and David Stanford. Front Row: John Seaton, Dan Sterk and Phillip McCorkle. All five join Newmark in leadership roles under the Newmark RF brand, bringing decades of experience in strategy, operations, technology and client advisory to the company.

“We are investing in scaled advisory and managed services capabilities that match the complexity of today’s institutional clients across the full asset lifecycle,” said Barry Gosin, Chief Executive Officer of Newmark Group, Inc. and Chairman of Newmark & Company Real Estate, Inc. “The acquisition of RealFoundations strengthens Newmark’s position as a leading global provider of investor and occupier solutions, advancing our goal to grow recurring Management Services and Servicing revenue to more than $2 billion by 2029.”

With more than 500 employees supporting 500 companies in the U.S., Europe and Asia-Pacific, RealFoundations has earned a reputation as the gold standard partner to global investment managers and institutional investors, providing data management, transaction support, performance analytics, valuation services and strategic consulting. The firm’s differentiated technology and end-to-end workflow systems allow clients to scale their back-office functions while gaining real-time visibility into portfolio-level data.

“RealFoundations’ consulting and managed services strengthen our ability to offer clients integrated investment services that support performance and client service delivery,” said Lou Alvarado, Chief Operating Officer. “By combining their delivery model and specialized expertise with our capital markets platform, we can help clients scale with even greater speed, efficiency and insight.”

The investment strengthens Newmark’s Managed Services for its investor clients, which now includes more than 1,000 professionals worldwide, as the firm broadens its delivery of Data Services, Lease Administration, Accounting, Reporting, Asset Services and newly launched Fund Administration at a global scale. RealFoundations adds advanced technology, consulting expertise and a complementary client base of leading REITs, investment managers and owners across office, retail, industrial, multifamily and single-family sectors, further expanding Newmark’s institutional reach.

“Joining Newmark is a natural next step for our firm,” said Chris Shaida, Founder and Chief Executive Officer of RealFoundations. “We share a commitment to delivering intelligent, client-focused solutions, and with Newmark’s global platform and client relationships, we are poised to broaden our impact and deepen our client relationships.”

The RealFoundations leadership team will continue to lead the business branded as Newmark RF, part of Newmark’s Investor Solutions group, maintaining service continuity while expanding its geographic reach and capabilities under the Newmark brand. Joining the leadership team alongside Newmark RF President Shaida is Executive Vice President of Growth David Stanford, Executive Vice President of Revenue John Seaton, Executive Vice President of Managed Services Dan Sterk and Executive Vice President of Management Consulting Phillip McCorkle. Together, they bring decades of experience in strategy, operations, technology and client advisory for the world’s leading real estate owners, operators and investors. The group will work collaboratively with Ania Jastrzebska, Senior Managing Director of Global Managed Services, while leveraging Newmark’s extensive capital markets relationships and track record of recent growth.

Newmark significantly increased the U.S. market share of its Capital Markets business over the past ten years, as the Company nearly tripled its investment sales market share and grew its percentage of commercial and multifamily originations by a multiple of six since 2015. Newmark was also the top-ranking U.S. office sales brokerage firm in the first half of 2025, according to Real Estate Alert. Additionally, Newmark continues to expand its Capital Markets footprint internationally, having recently announced the hiring of several leading investment sales and debt advisory professionals across the U.K., France and Germany.

Terms of the transaction were not disclosed. G-Side Capital Advisors served as exclusive financial advisor to RealFoundations. Newmark RF’s financial results will be included as part of the Company’s growing suite of recurring Management Services and Servicing businesses.

To learn more about Newmark RF, visit realfoundations.net.

About Newmark
Newmark Group, Inc. (Nasdaq: NMRK), together with its subsidiaries (“Newmark”), is a world leader in commercial real estate, seamlessly powering every phase of the property life cycle. Newmark’s comprehensive suite of services and products is uniquely tailored to each client, from owners to occupiers, investors to founders, and startups to blue-chip companies. Combining the platform’s global reach with market intelligence in both established and emerging property markets, Newmark provides superior service to clients across the industry spectrum. For the twelve months ended June 30, 2025, Newmark generated revenues of over $2.9 billion. As of June 30, 2025, Newmark and its business partners together operated from 165 offices with over 8,400 professionals across four continents. To learn more, visit nmrk.com or follow @newmark.

Discussion of Forward-Looking Statements about Newmark
Statements in this document regarding Newmark that are not historical facts are “forward-looking statements” that involve risks and uncertainties, which could cause actual results to differ from those contained in the forward-looking statements. These include statements about the Company’s business, results, financial position, liquidity, and outlook, which may constitute forward-looking statements and are subject to the risk that the actual impact may differ, possibly materially, from what is currently expected. Except as required by law, Newmark undertakes no obligation to update any forward-looking statements. For a discussion of additional risks and uncertainties, which could cause actual results to differ from those contained in the forward-looking statements, see Newmark’s Securities and Exchange Commission filings, including, but not limited to, the risk factors and Special Note on Forward-Looking Information set forth in these filings and any updates to such risk factors and Special Note on Forward-Looking Information contained in subsequent reports on Form 10-K, Form 10-Q or Form 8-K.

Newmark Group, Inc.

SYDNEY, Oct. 8, 2025 /PRNewswire/ — Today, Roborock is proud to announce its collaboration with ALDI, bringing the innovative F25 RT to ALDI stores for just $299, half the usual retail price. This partnership marks an exciting milestone, making Roborock’s cutting-edge cleaning solution more accessible to households nationwide.

Available to local shoppers from 8 October 2025, the Roborock F25 RT delivers high-performance cleaning that makes chores quicker and easier — all at an affordable price in a convenient, familiar location. With demand expected to be high, consumers will need to be quick to snap it up.

Designed to take the stress out of everyday mess, featuring a powerful 20,000 Pa suction the F25 RT easily lifts away dust, crumbs, and even stubborn pet hair, this lightweight vacuum makes fresh floors feel effortless.

Its FlatReach™ low-profile design glides seamlessly under sofas, beds, and hard to reach areas, whilst its clever Dual JawScrapers™ and an Anti-Entangle Edge Comb make for the perfect solution for families and pet owners.

The F25 RT takes care of itself, with a built-in hot-water self-cleaning system and hygienic hot-air drying cycle that washes and dries the roller in just 30 minutes, helping to eliminate odours and bacteria – no manual effort required.

Large water tanks and up to 35 minutes of runtime mean fewer interruptions, making it ideal for small to mid-sized homes. At just 4 kilograms, it’s easy to carry from room to room, proving powerful doesn’t have to mean heavy.

“We’re excited to bring the F25 RT to ALDI, connecting with their loyal shoppers and giving more Australians the chance to experience Roborock’s smart, high-performance cleaning technology at an accessible price.” Richard Chang, Founder & CEO of Roborock

The Roborock F25 RT is available in limited quantities, exclusively in Aldi’s Special Buys™ Aisle in stores nationwide, from the 8th October 2025 – get in quick, or you’ll miss it.

ABOUT ROBOROCK:
Roborock is a leading smart cleaning brand renowned for its intelligent cleaning solutions. With a steadfast dedication to becoming a global leader in smart appliances, Roborock enriches lives with its innovative line of robotic, cordless, wet/dry vacuum cleaners, and washer-dryers. Rooted in a user-centric approach, our R&D-driven solutions cater to diverse cleaning needs in over 15 million homes across 170+ countries. Headquartered in Beijing and with strategic subsidiaries worldwide, including the United States, Japan, Germany, and Australia, Roborock is committed to simplifying the way the world cleans.